#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P0DTD1-PRO_0000449623	uniprotkb:P0DTD1-PRO_0000449623	intact:EBI-25475864	intact:EBI-25475864	psi-mi:p0dtd1-pro_0000449623(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:p0dtd1-pro_0000449623(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	Lee et al. (2020)	pubmed:33208735|imex:IM-28519	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26453760|wwpdb:7jp1|imex:IM-28519-1|wwpdb:7KHP	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	chain-seq-start:3264|chain-seq-end:3569	chain-seq-start:3264|chain-seq-end:3569	figure legend:Supp. Table 1|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2020/11/20	2020/11/24	rogid:9u1TJXDTORfCyqj2bv2TlDMZ65c2697049	rogid:9u1TJXDTORfCyqj2bv2TlDMZ65c2697049	rigid:x8zjUh7Hu9Bss8jPnZX6S6ox/y8	false	-	-	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0DTD1-PRO_0000449623	uniprotkb:P0DTD1-PRO_0000449623	intact:EBI-25475864	intact:EBI-25475864	psi-mi:p0dtd1-pro_0000449623(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:p0dtd1-pro_0000449623(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	Lee et al. (2020)	pubmed:33208735|imex:IM-28519	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26453801|imex:IM-28519-3|wwpdb:7joy	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	chain-seq-start:3264|chain-seq-end:3569	chain-seq-start:3264|chain-seq-end:3569	figure legend:Supp. Table 1|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2020/11/20	2020/11/24	rogid:9u1TJXDTORfCyqj2bv2TlDMZ65c2697049	rogid:9u1TJXDTORfCyqj2bv2TlDMZ65c2697049	rigid:x8zjUh7Hu9Bss8jPnZX6S6ox/y8	false	mutation:145-145	mutation:145-145	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0DTD1-PRO_0000449623	uniprotkb:P0DTD1-PRO_0000449623	intact:EBI-25475864	intact:EBI-25475864	psi-mi:p0dtd1-pro_0000449623(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:p0dtd1-pro_0000449623(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0826"(x ray scattering)	Lee et al. (2020)	pubmed:33208735|imex:IM-28519	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26453863|imex:IM-28519-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	chain-seq-start:3264|chain-seq-end:3569	chain-seq-start:3264|chain-seq-end:3569	figure legend:Supp. Table 2, Supp. figure 2|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2020/11/20	2020/11/24	rogid:9u1TJXDTORfCyqj2bv2TlDMZ65c2697049	rogid:9u1TJXDTORfCyqj2bv2TlDMZ65c2697049	rigid:x8zjUh7Hu9Bss8jPnZX6S6ox/y8	false	mutation disrupting interaction strength:9-9	mutation disrupting interaction strength:9-9	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0DTD1-PRO_0000449623	uniprotkb:P0DTD1-PRO_0000449623	intact:EBI-25475864	intact:EBI-25475864	psi-mi:p0dtd1-pro_0000449623(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:p0dtd1-pro_0000449623(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0071"(molecular sieving)	Lee et al. (2020)	pubmed:33208735|imex:IM-28519	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26453868|imex:IM-28519-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	chain-seq-start:3264|chain-seq-end:3569	chain-seq-start:3264|chain-seq-end:3569	figure legend:Supp. figure 3|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2020/11/20	2020/11/24	rogid:9u1TJXDTORfCyqj2bv2TlDMZ65c2697049	rogid:9u1TJXDTORfCyqj2bv2TlDMZ65c2697049	rigid:x8zjUh7Hu9Bss8jPnZX6S6ox/y8	false	mutation decreasing interaction strength:9-9	mutation decreasing interaction strength:9-9	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0DTD1-PRO_0000449623	intact:EBI-25498052	intact:EBI-25475864	-	psi-mi:p0dtd1-pro_0000449623(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"mca-avlqsgfr-lys(dnp)-lys-nh2"(display_short)|psi-mi:EBI-25498052(display_long)	psi-mi:"MI:0990"(cleavage assay)	Lee et al. (2020)	pubmed:33208735|imex:IM-28519	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26453873|imex:IM-28519-9	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	go:"GO:0008234"(cysteine-type peptidase activity)	chain-seq-start:3264|chain-seq-end:3569	-	figure legend:Supp. figure 4|kinetic_conditions:Hill coefficient =~1.7 for Wild type and mutant.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kcat:0.54(second -1)	2020/11/20	2020/11/24	rogid:9u1TJXDTORfCyqj2bv2TlDMZ65c2697049	rogid:T1cb09aq7tIRd3UQsm3Tkk4+h5k-2	rigid:N4ZQX5Tr/eJetlDfNH5lJMRR5nQ	false	mutation disrupting interaction rate:9-9	fluorophore:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:31360"	intact:EBI-25498052	intact:EBI-25498422|chebi:"CHEBI:94505"	-	psi-mi:carmofur(display_short)|psi-mi:"CHEBI:31360"(display_long)|intact:1-hexylcarbamoyl-5-fluorouracil(synonym)|intact:Carmofur(synonym)|intact:mifurol(synonym)|intact:yamaful(synonym)	psi-mi:"mca-avlqsgfr-lys(dnp)-lys-nh2"(display_short)|psi-mi:EBI-25498052(display_long)	psi-mi:"MI:0990"(cleavage assay)	Lee et al. (2020)	pubmed:33208735|imex:IM-28519	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26453886|imex:IM-28519-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0327"(peptide)	-	-	go:"GO:0008234"(cysteine-type peptidase activity)	-	-	figure legend:Supp. figure 4|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:1.8x10^-6(molar)	2020/11/20	2020/11/24	-	rogid:T1cb09aq7tIRd3UQsm3Tkk4+h5k-2	-	false	-	fluorophore:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:31360"	uniprotkb:P0DTD1-PRO_0000449623	intact:EBI-25498422|chebi:"CHEBI:94505"	intact:EBI-25475864	psi-mi:carmofur(display_short)|psi-mi:"CHEBI:31360"(display_long)|intact:1-hexylcarbamoyl-5-fluorouracil(synonym)|intact:Carmofur(synonym)|intact:mifurol(synonym)|intact:yamaful(synonym)	psi-mi:p0dtd1-pro_0000449623(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0990"(cleavage assay)	Lee et al. (2020)	pubmed:33208735|imex:IM-28519	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26453886|imex:IM-28519-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	go:"GO:0008234"(cysteine-type peptidase activity)	-	chain-seq-start:3264|chain-seq-end:3569	figure legend:Supp. figure 4|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:1.8x10^-6(molar)	2020/11/20	2020/11/24	-	rogid:9u1TJXDTORfCyqj2bv2TlDMZ65c2697049	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)