#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chebi:"CHEBI:16960"	uniprotkb:P0DTD1-PRO_0000449621	intact:EBI-25618313|chebi:"CHEBI:40752"|chebi:"CHEBI:13231"|chebi:"CHEBI:2351"|chebi:"CHEBI:20850"|chebi:"CHEBI:32889"	intact:EBI-25492388	psi-mi:adp-d-ribose(display_short)|psi-mi:"CHEBI:16960"(display_long)|intact:"(Rib5)ppA"(synonym)|intact:"5-(adenosine 5'-pyrophosphoryl)-D-ribose"(synonym)|intact:A5'pp5Rib(synonym)|intact:"adenosine 5'-(trihydrogen diphosphate), P'-5-ester with D-ribose"(synonym)|intact:adenosine 5'-diphosphoribose(synonym)|intact:adenosine 5'-pyrophosphate, 5'-5-ester with D-ribofuranose(synonym)|intact:adenosine diphosphate ribose(synonym)|intact:Adenosine diphosphate ribose(synonym)|intact:AdoPPRib(synonym)|intact:ADP ribose(synonym)|intact:ADP-D-ribose(synonym)|intact:ADP-Rib(synonym)|intact:ADP-riboses(synonym)|intact:ADPribose(synonym)|intact:"D-ribofuranose, 5-5'-ester with adenosine 5'-(trihydrogen pyrophosphate)"(synonym)|intact:ribose adenosinediphosphate(synonym)|intact:"adenosine 5'-[3-(D-ribofuranos-5-O-yl) dihydrogen diphosphate]"(iupac name)	psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	Yousef et al. (2020)	imex:IM-28012|pubmed:33158944	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25618308|imex:IM-28012-21|wwpdb:6woj	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	-	chain-seq-start:819|chain-seq-end:2763	figure legend:Table 1|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/05/13	2020/06/12	-	rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049	-	false	-	sufficient binding region:205-379(IPR002589)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16960"	uniprotkb:P0DTD1-PRO_0000449621	intact:EBI-25618313|chebi:"CHEBI:40752"|chebi:"CHEBI:13231"|chebi:"CHEBI:2351"|chebi:"CHEBI:20850"|chebi:"CHEBI:32889"	intact:EBI-25492388	psi-mi:adp-d-ribose(display_short)|psi-mi:"CHEBI:16960"(display_long)|intact:"(Rib5)ppA"(synonym)|intact:"5-(adenosine 5'-pyrophosphoryl)-D-ribose"(synonym)|intact:A5'pp5Rib(synonym)|intact:"adenosine 5'-(trihydrogen diphosphate), P'-5-ester with D-ribose"(synonym)|intact:adenosine 5'-diphosphoribose(synonym)|intact:adenosine 5'-pyrophosphate, 5'-5-ester with D-ribofuranose(synonym)|intact:adenosine diphosphate ribose(synonym)|intact:Adenosine diphosphate ribose(synonym)|intact:AdoPPRib(synonym)|intact:ADP ribose(synonym)|intact:ADP-D-ribose(synonym)|intact:ADP-Rib(synonym)|intact:ADP-riboses(synonym)|intact:ADPribose(synonym)|intact:"D-ribofuranose, 5-5'-ester with adenosine 5'-(trihydrogen pyrophosphate)"(synonym)|intact:ribose adenosinediphosphate(synonym)|intact:"adenosine 5'-[3-(D-ribofuranos-5-O-yl) dihydrogen diphosphate]"(iupac name)	psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Yousef et al. (2020)	imex:IM-28012|pubmed:33158944	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25618363|imex:IM-28012-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	-	chain-seq-start:819|chain-seq-end:2763	figure legend:Figure 7 A/B|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:16.8x10^-6(molar)	2020/05/13	2020/06/02	-	rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049	-	false	-	sufficient binding region:205-379(IPR002589)|his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16960"	uniprotkb:A1Z1Q3	intact:EBI-25618313|chebi:"CHEBI:40752"|chebi:"CHEBI:13231"|chebi:"CHEBI:2351"|chebi:"CHEBI:20850"|chebi:"CHEBI:32889"	intact:EBI-16774808|ensembl:ENSP00000217246|uniprotkb:A6NFF7|uniprotkb:B0QZ39|uniprotkb:B3KWV0|uniprotkb:Q0P6D5|uniprotkb:Q495E0|uniprotkb:Q5W199|uniprotkb:Q6ZN71	psi-mi:adp-d-ribose(display_short)|psi-mi:"CHEBI:16960"(display_long)|intact:"(Rib5)ppA"(synonym)|intact:"5-(adenosine 5'-pyrophosphoryl)-D-ribose"(synonym)|intact:A5'pp5Rib(synonym)|intact:"adenosine 5'-(trihydrogen diphosphate), P'-5-ester with D-ribose"(synonym)|intact:adenosine 5'-diphosphoribose(synonym)|intact:adenosine 5'-pyrophosphate, 5'-5-ester with D-ribofuranose(synonym)|intact:adenosine diphosphate ribose(synonym)|intact:Adenosine diphosphate ribose(synonym)|intact:AdoPPRib(synonym)|intact:ADP ribose(synonym)|intact:ADP-D-ribose(synonym)|intact:ADP-Rib(synonym)|intact:ADP-riboses(synonym)|intact:ADPribose(synonym)|intact:"D-ribofuranose, 5-5'-ester with adenosine 5'-(trihydrogen pyrophosphate)"(synonym)|intact:ribose adenosinediphosphate(synonym)|intact:"adenosine 5'-[3-(D-ribofuranos-5-O-yl) dihydrogen diphosphate]"(iupac name)	psi-mi:macd2_human(display_long)|uniprotkb:MACROD2(gene name)|psi-mi:MACROD2(display_short)|uniprotkb:C20orf133(gene name synonym)|uniprotkb:O-acetyl-ADP-ribose deacetylase MACROD2(gene name synonym)|uniprotkb:[Protein ADP-ribosylaspartate] hydrolase MACROD2(gene name synonym)|uniprotkb:[Protein ADP-ribosylglutamate] hydrolase MACROD2(gene name synonym)|uniprotkb:MACRO domain-containing protein 2(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Yousef et al. (2020)	imex:IM-28012|pubmed:33158944	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25618406|imex:IM-28012-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000172264(gene)|ensembl:ENST00000217246(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016798"(hydrolase activity, acting on glycosyl bonds)|go:"GO:0019213"(deacetylase activity)|go:"GO:0042278"(purine nucleoside metabolic process)|go:"GO:0051725"(protein de-ADP-ribosylation)|go:"GO:0140291"(peptidyl-glutamate ADP-deribosylation)|go:"GO:0140293"(ADP-ribosylglutamate hydrolase activity)|interpro:IPR002589(Appr-1-p processing)|interpro:IPR043472|rcsb pdb:4IQY|rcsb pdb:6Y4Y|rcsb pdb:6Y4Z|rcsb pdb:6Y73|refseq:NP_001028259.1|refseq:NP_542407.2|refseq:XP_016883166.1	-	-	-	figure legend:Figure 7 A/B|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.24x10^-6(molar)	2020/05/13	2020/05/21	-	rogid:NLU3D+VMEMDIk477Ch5xHDoRgmA9606	-	false	-	sufficient binding region:7-243(IPR002589)|his tag:n-n|v5 tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16960"	uniprotkb:P0C6U8-PRO_0000338257	intact:EBI-25618313|chebi:"CHEBI:40752"|chebi:"CHEBI:13231"|chebi:"CHEBI:2351"|chebi:"CHEBI:20850"|chebi:"CHEBI:32889"	intact:EBI-25635190	psi-mi:adp-d-ribose(display_short)|psi-mi:"CHEBI:16960"(display_long)|intact:"(Rib5)ppA"(synonym)|intact:"5-(adenosine 5'-pyrophosphoryl)-D-ribose"(synonym)|intact:A5'pp5Rib(synonym)|intact:"adenosine 5'-(trihydrogen diphosphate), P'-5-ester with D-ribose"(synonym)|intact:adenosine 5'-diphosphoribose(synonym)|intact:adenosine 5'-pyrophosphate, 5'-5-ester with D-ribofuranose(synonym)|intact:adenosine diphosphate ribose(synonym)|intact:Adenosine diphosphate ribose(synonym)|intact:AdoPPRib(synonym)|intact:ADP ribose(synonym)|intact:ADP-D-ribose(synonym)|intact:ADP-Rib(synonym)|intact:ADP-riboses(synonym)|intact:ADPribose(synonym)|intact:"D-ribofuranose, 5-5'-ester with adenosine 5'-(trihydrogen pyrophosphate)"(synonym)|intact:ribose adenosinediphosphate(synonym)|intact:"adenosine 5'-[3-(D-ribofuranos-5-O-yl) dihydrogen diphosphate]"(iupac name)	psi-mi:p0c6u8-pro_0000338257(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Yousef et al. (2020)	imex:IM-28012|pubmed:33158944	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25618417|imex:IM-28012-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-15810860(chain-parent)	-	-	chain-seq-start:819|chain-seq-end:2740	figure legend:Figure 7 A/B|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:10.8x10^-6(molar)	2020/05/13	2020/06/02	-	rogid:NKZ5d0D2HjefhmJQwgHz+M1lSt8694009	-	false	-	sufficient binding region:182-354(IPR002589)|his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16960"	uniprotkb:K9N638-PRO_0000422456	intact:EBI-25618313|chebi:"CHEBI:40752"|chebi:"CHEBI:13231"|chebi:"CHEBI:2351"|chebi:"CHEBI:20850"|chebi:"CHEBI:32889"	intact:EBI-25635184	psi-mi:adp-d-ribose(display_short)|psi-mi:"CHEBI:16960"(display_long)|intact:"(Rib5)ppA"(synonym)|intact:"5-(adenosine 5'-pyrophosphoryl)-D-ribose"(synonym)|intact:A5'pp5Rib(synonym)|intact:"adenosine 5'-(trihydrogen diphosphate), P'-5-ester with D-ribose"(synonym)|intact:adenosine 5'-diphosphoribose(synonym)|intact:adenosine 5'-pyrophosphate, 5'-5-ester with D-ribofuranose(synonym)|intact:adenosine diphosphate ribose(synonym)|intact:Adenosine diphosphate ribose(synonym)|intact:AdoPPRib(synonym)|intact:ADP ribose(synonym)|intact:ADP-D-ribose(synonym)|intact:ADP-Rib(synonym)|intact:ADP-riboses(synonym)|intact:ADPribose(synonym)|intact:"D-ribofuranose, 5-5'-ester with adenosine 5'-(trihydrogen pyrophosphate)"(synonym)|intact:ribose adenosinediphosphate(synonym)|intact:"adenosine 5'-[3-(D-ribofuranos-5-O-yl) dihydrogen diphosphate]"(iupac name)	psi-mi:k9n638-pro_0000422456(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Yousef et al. (2020)	imex:IM-28012|pubmed:33158944	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:1263720(cvemc)|taxid:1263720("Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25618439|imex:IM-28012-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-25618448(chain-parent)	-	-	chain-seq-start:854|chain-seq-end:2740	figure legend:Figure 7 A/B|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:10.8x10^-6(molar)	2020/05/13	2020/06/02	-	rogid:P9NSm1IurgKbORStjY9C/5q21WM1263720	-	false	-	sufficient binding region:257-420(IPR002589)|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16960"	uniprotkb:K9N638-PRO_0000422456	intact:EBI-25618313|chebi:"CHEBI:40752"|chebi:"CHEBI:13231"|chebi:"CHEBI:2351"|chebi:"CHEBI:20850"|chebi:"CHEBI:32889"	intact:EBI-25635184	psi-mi:adp-d-ribose(display_short)|psi-mi:"CHEBI:16960"(display_long)|intact:"(Rib5)ppA"(synonym)|intact:"5-(adenosine 5'-pyrophosphoryl)-D-ribose"(synonym)|intact:A5'pp5Rib(synonym)|intact:"adenosine 5'-(trihydrogen diphosphate), P'-5-ester with D-ribose"(synonym)|intact:adenosine 5'-diphosphoribose(synonym)|intact:adenosine 5'-pyrophosphate, 5'-5-ester with D-ribofuranose(synonym)|intact:adenosine diphosphate ribose(synonym)|intact:Adenosine diphosphate ribose(synonym)|intact:AdoPPRib(synonym)|intact:ADP ribose(synonym)|intact:ADP-D-ribose(synonym)|intact:ADP-Rib(synonym)|intact:ADP-riboses(synonym)|intact:ADPribose(synonym)|intact:"D-ribofuranose, 5-5'-ester with adenosine 5'-(trihydrogen pyrophosphate)"(synonym)|intact:ribose adenosinediphosphate(synonym)|intact:"adenosine 5'-[3-(D-ribofuranos-5-O-yl) dihydrogen diphosphate]"(iupac name)	psi-mi:k9n638-pro_0000422456(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:"MI:1235"(thermal shift binding)	Yousef et al. (2020)	imex:IM-28012|pubmed:33158944	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:1263720(cvemc)|taxid:1263720("Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25618895|imex:IM-28012-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-25618448(chain-parent)	-	-	chain-seq-start:854|chain-seq-end:2740	figure legend:Figure  7C|comment:All 4 macrodomains tested denatured at   higher temperatures with the addition of ADP-ribose.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/05/13	2020/06/02	-	rogid:P9NSm1IurgKbORStjY9C/5q21WM1263720	-	false	-	sufficient binding region:257-420(IPR002589)|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16960"	uniprotkb:P0C6U8-PRO_0000338257	intact:EBI-25618313|chebi:"CHEBI:40752"|chebi:"CHEBI:13231"|chebi:"CHEBI:2351"|chebi:"CHEBI:20850"|chebi:"CHEBI:32889"	intact:EBI-25635190	psi-mi:adp-d-ribose(display_short)|psi-mi:"CHEBI:16960"(display_long)|intact:"(Rib5)ppA"(synonym)|intact:"5-(adenosine 5'-pyrophosphoryl)-D-ribose"(synonym)|intact:A5'pp5Rib(synonym)|intact:"adenosine 5'-(trihydrogen diphosphate), P'-5-ester with D-ribose"(synonym)|intact:adenosine 5'-diphosphoribose(synonym)|intact:adenosine 5'-pyrophosphate, 5'-5-ester with D-ribofuranose(synonym)|intact:adenosine diphosphate ribose(synonym)|intact:Adenosine diphosphate ribose(synonym)|intact:AdoPPRib(synonym)|intact:ADP ribose(synonym)|intact:ADP-D-ribose(synonym)|intact:ADP-Rib(synonym)|intact:ADP-riboses(synonym)|intact:ADPribose(synonym)|intact:"D-ribofuranose, 5-5'-ester with adenosine 5'-(trihydrogen pyrophosphate)"(synonym)|intact:ribose adenosinediphosphate(synonym)|intact:"adenosine 5'-[3-(D-ribofuranos-5-O-yl) dihydrogen diphosphate]"(iupac name)	psi-mi:p0c6u8-pro_0000338257(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:"MI:1235"(thermal shift binding)	Yousef et al. (2020)	imex:IM-28012|pubmed:33158944	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25618915|imex:IM-28012-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-15810860(chain-parent)	-	-	chain-seq-start:819|chain-seq-end:2740	figure legend:Figure 7 C|comment:All 4 macrodomains tested denatured at   higher temperatures with the addition of ADP-ribose.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/05/13	2020/06/02	-	rogid:NKZ5d0D2HjefhmJQwgHz+M1lSt8694009	-	false	-	sufficient binding region:182-354|his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16960"	uniprotkb:P0DTD1-PRO_0000449621	intact:EBI-25618313|chebi:"CHEBI:40752"|chebi:"CHEBI:13231"|chebi:"CHEBI:2351"|chebi:"CHEBI:20850"|chebi:"CHEBI:32889"	intact:EBI-25492388	psi-mi:adp-d-ribose(display_short)|psi-mi:"CHEBI:16960"(display_long)|intact:"(Rib5)ppA"(synonym)|intact:"5-(adenosine 5'-pyrophosphoryl)-D-ribose"(synonym)|intact:A5'pp5Rib(synonym)|intact:"adenosine 5'-(trihydrogen diphosphate), P'-5-ester with D-ribose"(synonym)|intact:adenosine 5'-diphosphoribose(synonym)|intact:adenosine 5'-pyrophosphate, 5'-5-ester with D-ribofuranose(synonym)|intact:adenosine diphosphate ribose(synonym)|intact:Adenosine diphosphate ribose(synonym)|intact:AdoPPRib(synonym)|intact:ADP ribose(synonym)|intact:ADP-D-ribose(synonym)|intact:ADP-Rib(synonym)|intact:ADP-riboses(synonym)|intact:ADPribose(synonym)|intact:"D-ribofuranose, 5-5'-ester with adenosine 5'-(trihydrogen pyrophosphate)"(synonym)|intact:ribose adenosinediphosphate(synonym)|intact:"adenosine 5'-[3-(D-ribofuranos-5-O-yl) dihydrogen diphosphate]"(iupac name)	psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:1235"(thermal shift binding)	Yousef et al. (2020)	imex:IM-28012|pubmed:33158944	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25618886|imex:IM-28012-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	-	chain-seq-start:819|chain-seq-end:2763	figure legend:Figure 7C|comment:All 4 macrodomains tested denatured at   higher temperatures with the addition of ADP-ribose.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/05/13	2020/06/02	-	rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049	-	false	-	sufficient binding region:205-379(IPR002589)|his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16960"	uniprotkb:A1Z1Q3	intact:EBI-25618313|chebi:"CHEBI:40752"|chebi:"CHEBI:13231"|chebi:"CHEBI:2351"|chebi:"CHEBI:20850"|chebi:"CHEBI:32889"	intact:EBI-16774808|ensembl:ENSP00000217246|uniprotkb:A6NFF7|uniprotkb:B0QZ39|uniprotkb:B3KWV0|uniprotkb:Q0P6D5|uniprotkb:Q495E0|uniprotkb:Q5W199|uniprotkb:Q6ZN71	psi-mi:adp-d-ribose(display_short)|psi-mi:"CHEBI:16960"(display_long)|intact:"(Rib5)ppA"(synonym)|intact:"5-(adenosine 5'-pyrophosphoryl)-D-ribose"(synonym)|intact:A5'pp5Rib(synonym)|intact:"adenosine 5'-(trihydrogen diphosphate), P'-5-ester with D-ribose"(synonym)|intact:adenosine 5'-diphosphoribose(synonym)|intact:adenosine 5'-pyrophosphate, 5'-5-ester with D-ribofuranose(synonym)|intact:adenosine diphosphate ribose(synonym)|intact:Adenosine diphosphate ribose(synonym)|intact:AdoPPRib(synonym)|intact:ADP ribose(synonym)|intact:ADP-D-ribose(synonym)|intact:ADP-Rib(synonym)|intact:ADP-riboses(synonym)|intact:ADPribose(synonym)|intact:"D-ribofuranose, 5-5'-ester with adenosine 5'-(trihydrogen pyrophosphate)"(synonym)|intact:ribose adenosinediphosphate(synonym)|intact:"adenosine 5'-[3-(D-ribofuranos-5-O-yl) dihydrogen diphosphate]"(iupac name)	psi-mi:macd2_human(display_long)|uniprotkb:MACROD2(gene name)|psi-mi:MACROD2(display_short)|uniprotkb:C20orf133(gene name synonym)|uniprotkb:O-acetyl-ADP-ribose deacetylase MACROD2(gene name synonym)|uniprotkb:[Protein ADP-ribosylaspartate] hydrolase MACROD2(gene name synonym)|uniprotkb:[Protein ADP-ribosylglutamate] hydrolase MACROD2(gene name synonym)|uniprotkb:MACRO domain-containing protein 2(gene name synonym)	psi-mi:"MI:1235"(thermal shift binding)	Yousef et al. (2020)	imex:IM-28012|pubmed:33158944	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25618990|imex:IM-28012-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000172264(gene)|ensembl:ENST00000217246(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016798"(hydrolase activity, acting on glycosyl bonds)|go:"GO:0019213"(deacetylase activity)|go:"GO:0042278"(purine nucleoside metabolic process)|go:"GO:0051725"(protein de-ADP-ribosylation)|go:"GO:0140291"(peptidyl-glutamate ADP-deribosylation)|go:"GO:0140293"(ADP-ribosylglutamate hydrolase activity)|interpro:IPR002589(Appr-1-p processing)|interpro:IPR043472|rcsb pdb:4IQY|rcsb pdb:6Y4Y|rcsb pdb:6Y4Z|rcsb pdb:6Y73|refseq:NP_001028259.1|refseq:NP_542407.2|refseq:XP_016883166.1	-	-	-	figure legend:Figure 7C|comment:All 4 macrodomains tested denatured at   higher temperatures with the addition of ADP-ribose.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/05/13	2020/05/22	-	rogid:NLU3D+VMEMDIk477Ch5xHDoRgmA9606	-	false	-	sufficient binding region:7-243(IPR002589)|his tag:n-n|v5 tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:A1Z1Q3	uniprotkb:Q53GL7	intact:EBI-16774808|ensembl:ENSP00000217246|uniprotkb:A6NFF7|uniprotkb:B0QZ39|uniprotkb:B3KWV0|uniprotkb:Q0P6D5|uniprotkb:Q495E0|uniprotkb:Q5W199|uniprotkb:Q6ZN71	intact:EBI-2857573|uniprotkb:Q8N2I0|uniprotkb:Q8WV05|uniprotkb:Q96CH7|uniprotkb:Q96K72|ensembl:ENSP00000325618	psi-mi:macd2_human(display_long)|uniprotkb:MACROD2(gene name)|psi-mi:MACROD2(display_short)|uniprotkb:C20orf133(gene name synonym)|uniprotkb:O-acetyl-ADP-ribose deacetylase MACROD2(gene name synonym)|uniprotkb:[Protein ADP-ribosylaspartate] hydrolase MACROD2(gene name synonym)|uniprotkb:[Protein ADP-ribosylglutamate] hydrolase MACROD2(gene name synonym)|uniprotkb:MACRO domain-containing protein 2(gene name synonym)	psi-mi:par10_human(display_long)|uniprotkb:Poly [ADP-ribose] polymerase 10(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 10(gene name synonym)|uniprotkb:PARP10(gene name)|psi-mi:PARP10(display_short)	psi-mi:"MI:1309"(de-ADP-ribosylation assay)	Yousef et al. (2020)	imex:IM-28012|pubmed:33158944	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:1310"(de-ADP-ribosylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25618904|imex:IM-28012-13	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000172264(gene)|ensembl:ENST00000217246(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016798"(hydrolase activity, acting on glycosyl bonds)|go:"GO:0019213"(deacetylase activity)|go:"GO:0042278"(purine nucleoside metabolic process)|go:"GO:0051725"(protein de-ADP-ribosylation)|go:"GO:0140291"(peptidyl-glutamate ADP-deribosylation)|go:"GO:0140293"(ADP-ribosylglutamate hydrolase activity)|interpro:IPR002589(Appr-1-p processing)|interpro:IPR043472|rcsb pdb:4IQY|rcsb pdb:6Y4Y|rcsb pdb:6Y4Z|rcsb pdb:6Y73|refseq:NP_001028259.1|refseq:NP_542407.2|refseq:XP_016883166.1	refseq:NP_116178.2|go:"GO:0034356"(NAD biosynthesis via nicotinamide riboside salvage pathway)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0140289"(protein mono-ADP-ribosylation)|go:"GO:1900045"(negative regulation of protein K63-linked ubiquitination)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034464|rcsb pdb:2DHX|rcsb pdb:3HKV|rcsb pdb:5LX6|rcsb pdb:6FXI|reactome:R-HSA-197264|reactome:R-HSA-9683610|reactome:R-HSA-9694631|ensembl:ENSG00000178685(gene)|ensembl:ENST00000313028(transcript)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010847"(regulation of chromatin assembly)|go:"GO:0019082"(viral protein processing)|go:"GO:0019985"(translesion synthesis)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)	go:"GO:0051725"(protein de-ADP-ribosylation)	-	-	figure legend:Figure 9|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/05/13	2020/06/10	rogid:NLU3D+VMEMDIk477Ch5xHDoRgmA9606	rogid:WcJRnNPrEAYD6vk9c4ACoh5fX1U9606	rigid:k4Eeai15SfnCRBtpzdelfD1yzVs	false	sufficient binding region:7-243(IPR002589)|his tag:n-n|v5 tag:n-n	glutathione s tranferase tag:n-n|sufficient binding region:818-1025(IPR012317)|"monoadenosine diphosphoribosyl (ADP-ribosyl) modified residue":?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q53GL7	uniprotkb:K9N638-PRO_0000422456	intact:EBI-2857573|uniprotkb:Q8N2I0|uniprotkb:Q8WV05|uniprotkb:Q96CH7|uniprotkb:Q96K72|ensembl:ENSP00000325618	intact:EBI-25635184	psi-mi:par10_human(display_long)|uniprotkb:Poly [ADP-ribose] polymerase 10(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 10(gene name synonym)|uniprotkb:PARP10(gene name)|psi-mi:PARP10(display_short)	psi-mi:k9n638-pro_0000422456(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:"MI:1309"(de-ADP-ribosylation assay)	Yousef et al. (2020)	imex:IM-28012|pubmed:33158944	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:1263720(cvemc)|taxid:1263720("Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1)")	psi-mi:"MI:1310"(de-ADP-ribosylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25618963|imex:IM-28012-17	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116178.2|go:"GO:0034356"(NAD biosynthesis via nicotinamide riboside salvage pathway)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0140289"(protein mono-ADP-ribosylation)|go:"GO:1900045"(negative regulation of protein K63-linked ubiquitination)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034464|rcsb pdb:2DHX|rcsb pdb:3HKV|rcsb pdb:5LX6|rcsb pdb:6FXI|reactome:R-HSA-197264|reactome:R-HSA-9683610|reactome:R-HSA-9694631|ensembl:ENSG00000178685(gene)|ensembl:ENST00000313028(transcript)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010847"(regulation of chromatin assembly)|go:"GO:0019082"(viral protein processing)|go:"GO:0019985"(translesion synthesis)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)	intact:EBI-25618448(chain-parent)	go:"GO:0051725"(protein de-ADP-ribosylation)	-	chain-seq-start:854|chain-seq-end:2740	figure legend:Figure 9|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/05/13	2020/06/10	rogid:WcJRnNPrEAYD6vk9c4ACoh5fX1U9606	rogid:P9NSm1IurgKbORStjY9C/5q21WM1263720	rigid:DtbJ97Ml1tfc1s1tEHUYCaknKCQ	false	glutathione s tranferase tag:n-n|sufficient binding region:818-1025(IPR012317)|"monoadenosine diphosphoribosyl (ADP-ribosyl) modified residue":?-?	sufficient binding region:257-420(IPR002589)|his tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q53GL7	uniprotkb:P0C6U8-PRO_0000338257	intact:EBI-2857573|uniprotkb:Q8N2I0|uniprotkb:Q8WV05|uniprotkb:Q96CH7|uniprotkb:Q96K72|ensembl:ENSP00000325618	intact:EBI-25635190	psi-mi:par10_human(display_long)|uniprotkb:Poly [ADP-ribose] polymerase 10(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 10(gene name synonym)|uniprotkb:PARP10(gene name)|psi-mi:PARP10(display_short)	psi-mi:p0c6u8-pro_0000338257(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:"MI:1309"(de-ADP-ribosylation assay)	Yousef et al. (2020)	imex:IM-28012|pubmed:33158944	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	psi-mi:"MI:1310"(de-ADP-ribosylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25619173|imex:IM-28012-23	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116178.2|go:"GO:0034356"(NAD biosynthesis via nicotinamide riboside salvage pathway)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0140289"(protein mono-ADP-ribosylation)|go:"GO:1900045"(negative regulation of protein K63-linked ubiquitination)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034464|rcsb pdb:2DHX|rcsb pdb:3HKV|rcsb pdb:5LX6|rcsb pdb:6FXI|reactome:R-HSA-197264|reactome:R-HSA-9683610|reactome:R-HSA-9694631|ensembl:ENSG00000178685(gene)|ensembl:ENST00000313028(transcript)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010847"(regulation of chromatin assembly)|go:"GO:0019082"(viral protein processing)|go:"GO:0019985"(translesion synthesis)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)	intact:EBI-15810860(chain-parent)	go:"GO:0051725"(protein de-ADP-ribosylation)	-	chain-seq-start:819|chain-seq-end:2740	figure legend:Figure 9|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/05/13	2020/06/10	rogid:WcJRnNPrEAYD6vk9c4ACoh5fX1U9606	rogid:NKZ5d0D2HjefhmJQwgHz+M1lSt8694009	rigid:3gujXU0jwqZIpPb/HCcZ+uiSpIA	false	glutathione s tranferase tag:n-n|sufficient binding region:818-1025(IPR012317)|"monoadenosine diphosphoribosyl (ADP-ribosyl) modified residue":?-?	his tag:n-n|sufficient binding region:182-354(IPR002589)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q53GL7	uniprotkb:P0DTD1-PRO_0000449621	intact:EBI-2857573|uniprotkb:Q8N2I0|uniprotkb:Q8WV05|uniprotkb:Q96CH7|uniprotkb:Q96K72|ensembl:ENSP00000325618	intact:EBI-25492388	psi-mi:par10_human(display_long)|uniprotkb:Poly [ADP-ribose] polymerase 10(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 10(gene name synonym)|uniprotkb:PARP10(gene name)|psi-mi:PARP10(display_short)	psi-mi:p0dtd1-pro_0000449621(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:1309"(de-ADP-ribosylation assay)	Yousef et al. (2020)	imex:IM-28012|pubmed:33158944	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:1310"(de-ADP-ribosylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25619194|imex:IM-28012-25	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116178.2|go:"GO:0034356"(NAD biosynthesis via nicotinamide riboside salvage pathway)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0140289"(protein mono-ADP-ribosylation)|go:"GO:1900045"(negative regulation of protein K63-linked ubiquitination)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034464|rcsb pdb:2DHX|rcsb pdb:3HKV|rcsb pdb:5LX6|rcsb pdb:6FXI|reactome:R-HSA-197264|reactome:R-HSA-9683610|reactome:R-HSA-9694631|ensembl:ENSG00000178685(gene)|ensembl:ENST00000313028(transcript)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010847"(regulation of chromatin assembly)|go:"GO:0019082"(viral protein processing)|go:"GO:0019985"(translesion synthesis)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	go:"GO:0051725"(protein de-ADP-ribosylation)	-	chain-seq-start:819|chain-seq-end:2763	figure legend:Figure 11|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/05/13	2020/06/10	rogid:WcJRnNPrEAYD6vk9c4ACoh5fX1U9606	rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049	rigid:U1zqkS/fHW6BtwofLc70Db/XUR0	false	glutathione s tranferase tag:n-n|sufficient binding region:818-1025(IPR012317)|"monoadenosine diphosphoribosyl (ADP-ribosyl) modified residue":?-?	sufficient binding region:205-379(IPR002589)|his tag:n-n	-	-	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)