#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P0DTC2	chembl target:CHEMBL2095226	intact:EBI-25474821	intact:EBI-2550721|reactome:R-HSA-202730|matrixdb:MULT_15_human|wwpdb:3vi3|signor:SIGNOR-C163	psi-mi:spike_sars2(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name)	psi-mi:intg_a5_b1_human(display_short)|psi-mi:CHEMBL2095226(display_long)|intact:alpha-5/beta-1 integrin complex(complex synonym)|intact:alpha5-beta1 integrin complex(complex synonym)|intact:"ITGA5:ITGB1"(complex systematic name)|intact:Integrin alpha5-beta1 complex(complex recommended name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Beddingfield et al. (2020)	pubmed:33102950|imex:IM-28488	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26429770|imex:IM-28488-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	interpro:IPR043002|interpro:IPR044873|rcsb pdb:7MJI|rcsb pdb:7MJJ|rcsb pdb:7MJK|rcsb pdb:7MJL|rcsb pdb:7MJM|rcsb pdb:7MJN|rcsb pdb:7MKB|rcsb pdb:7MKL|rcsb pdb:7MKM|rcsb pdb:7MMO|rcsb pdb:7MY2|rcsb pdb:7MY3|rcsb pdb:7N0G|rcsb pdb:7N0H|rcsb pdb:7NEG|rcsb pdb:7NKT|rcsb pdb:7NT9|rcsb pdb:7NTA|rcsb pdb:7NTC|rcsb pdb:7NX6|rcsb pdb:7NX7|rcsb pdb:7NX8|rcsb pdb:7NX9|rcsb pdb:7NXA|rcsb pdb:7NXB|rcsb pdb:7NXC|rcsb pdb:7AKD|rcsb pdb:7B14|rcsb pdb:7B18|rcsb pdb:7B62|rcsb pdb:7C53|rcsb pdb:7CHO|rcsb pdb:7CHP|rcsb pdb:7CHS|rcsb pdb:7CN4|rcsb pdb:7CWT|rcsb pdb:7CYH|rcsb pdb:7CYP|rcsb pdb:7CZP|rcsb pdb:7CZQ|rcsb pdb:7CZR|rcsb pdb:7CZS|rcsb pdb:7CZT|rcsb pdb:7CZU|rcsb pdb:7CZV|rcsb pdb:7CZW|rcsb pdb:7CZX|rcsb pdb:7CZY|rcsb pdb:7CZZ|rcsb pdb:7D00|rcsb pdb:7D03|rcsb pdb:7D0B|rcsb pdb:7D0C|rcsb pdb:7D0D|rcsb pdb:7D4G|rcsb pdb:7DEO|rcsb pdb:7DET|rcsb pdb:7DEU|interpro:IPR044874|rcsb pdb:7DJZ|rcsb pdb:7DK0|rcsb pdb:7DWX|rcsb pdb:7DWY|rcsb pdb:7DWZ|rcsb pdb:7DX0|rcsb pdb:7DX1|rcsb pdb:7DX2|rcsb pdb:7DX3|rcsb pdb:7DX4|rcsb pdb:7DX5|rcsb pdb:7DX6|rcsb pdb:7DX7|rcsb pdb:7DX8|rcsb pdb:7DX9|rcsb pdb:7DZW|rcsb pdb:7DZX|rcsb pdb:7DZY|rcsb pdb:7E23|rcsb pdb:7E3J|rcsb pdb:7E5Y|rcsb pdb:7E7B|rcsb pdb:7E7D|rcsb pdb:7E7X|rcsb pdb:7E7Y|rcsb pdb:7E86|rcsb pdb:7E88|rcsb pdb:7E8C|rcsb pdb:7E8F|rcsb pdb:7E8M|rcsb pdb:7EAM|rcsb pdb:7EAN|rcsb pdb:7EAZ|rcsb pdb:7EB0|rcsb pdb:7EB3|rcsb pdb:7EB4|rcsb pdb:7EB5|rcsb pdb:7EJ4|rcsb pdb:7EJ5|rcsb pdb:7EK6|rcsb pdb:7KFV|rcsb pdb:7KFW|rcsb pdb:7KFX|rcsb pdb:7KFY|rcsb pdb:7KQB|rcsb pdb:7KQE|rcsb pdb:7KRQ|rcsb pdb:7KRR|rcsb pdb:7KRS|rcsb pdb:7L2D|rcsb pdb:7L2E|rcsb pdb:7L2F|rcsb pdb:7L4Z|rcsb pdb:7L56|rcsb pdb:7L57|rcsb pdb:7L58|rcsb pdb:7LAA|rcsb pdb:7LAB|rcsb pdb:7LC8|rcsb pdb:7LDJ|rcsb pdb:7LJR|rcsb pdb:7LM8|rcsb pdb:7LO4|rcsb pdb:7LQV|rcsb pdb:7LQW|rcsb pdb:7LS9|rcsb pdb:7LSS|rcsb pdb:7LWI|rcsb pdb:7LWJ|rcsb pdb:7LWK|rcsb pdb:7LWL|rcsb pdb:7LWM|rcsb pdb:7LWN|rcsb pdb:7LWO|rcsb pdb:7LWP|rcsb pdb:7LWQ|rcsb pdb:7LWS|rcsb pdb:7LWT|rcsb pdb:7LWU|rcsb pdb:7LWV|rcsb pdb:7LWW|rcsb pdb:7LX5|rcsb pdb:7LXW|rcsb pdb:7LXX|rcsb pdb:7LXY|rcsb pdb:7LXZ|rcsb pdb:7LY0|rcsb pdb:7LY2|rcsb pdb:7LY3|rcsb pdb:7LYK|rcsb pdb:7LYL|rcsb pdb:7LYM|rcsb pdb:7LYN|rcsb pdb:7LYO|rcsb pdb:7LYP|rcsb pdb:7LYQ|rcsb pdb:7M0J|rcsb pdb:7M6D|rcsb pdb:7M6E|rcsb pdb:7M6F|rcsb pdb:7M6G|rcsb pdb:7M6H|rcsb pdb:7M6I|rcsb pdb:7M71|rcsb pdb:7M7B|rcsb pdb:7M7W|rcsb pdb:7M8J|rcsb pdb:7M8K|rcsb pdb:7M8S|rcsb pdb:7M8T|rcsb pdb:7M8U|rcsb pdb:7MF1|rcsb pdb:7MFU|rcsb pdb:7M3I|rcsb pdb:7M53|rcsb pdb:7MJG|rcsb pdb:7MJH|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|interpro:IPR043473|rcsb pdb:6LZG|rcsb pdb:6VW1|rcsb pdb:6YLA|rcsb pdb:6YM0|rcsb pdb:6YOR|rcsb pdb:7BZ5|refseq:YP_009724390.1|rcsb pdb:7KMG|rcsb pdb:7KMH|rcsb pdb:7KMI|rcsb pdb:7KMK|rcsb pdb:7KML|rcsb pdb:7KN5|rcsb pdb:7KN6|rcsb pdb:7KN7|rcsb pdb:7KS9|rcsb pdb:7KSG|rcsb pdb:7KXJ|rcsb pdb:7KXK|rcsb pdb:7KZB|rcsb pdb:7L0N|rcsb pdb:7L2C|rcsb pdb:7L3N|rcsb pdb:7L5B|rcsb pdb:7L7F|rcsb pdb:7L7K|rcsb pdb:7LCN|rcsb pdb:7LD1|rcsb pdb:7LOP|rcsb pdb:7ND3|rcsb pdb:7ND4|rcsb pdb:7ND5|rcsb pdb:7ND6|rcsb pdb:7ND7|rcsb pdb:7ND8|rcsb pdb:7ND9|rcsb pdb:7NDA|rcsb pdb:7NDB|rcsb pdb:7NDC|rcsb pdb:7NDD|rcsb pdb:7NEH|rcsb pdb:7B17|rcsb pdb:7BEH|rcsb pdb:7BEI|rcsb pdb:7BEJ|rcsb pdb:7BEK|rcsb pdb:7BEL|rcsb pdb:7BEM|rcsb pdb:7BEN|rcsb pdb:7BEO|rcsb pdb:7BEP|rcsb pdb:7C8J|rcsb pdb:7CAC|rcsb pdb:7CM4|rcsb pdb:7CWL|rcsb pdb:7D2Z|rcsb pdb:7D30|rcsb pdb:7DPM|rcsb pdb:7KGJ|rcsb pdb:7KGK|rcsb pdb:7KLG|rcsb pdb:7KLH|rcsb pdb:7KLW|interpro:IPR042578|rcsb pdb:7CAB|interpro:IPR044341|rcsb pdb:7CDI|interpro:IPR044366|rcsb pdb:7CDJ|rcsb pdb:6ZLR|rcsb pdb:7CJF|rcsb pdb:7CT5|rcsb pdb:7A25|rcsb pdb:7CWM|rcsb pdb:7CWN|rcsb pdb:7CWO|rcsb pdb:7CWS|rcsb pdb:7CWU|rcsb pdb:7DCC|rcsb pdb:7DCX|rcsb pdb:7DD2|rcsb pdb:7DD8|rcsb pdb:7DDD|rcsb pdb:7DDN|rcsb pdb:7DF3|rcsb pdb:7DF4|rcsb pdb:7DK3|rcsb pdb:7DK4|rcsb pdb:7DK5|rcsb pdb:7DK6|rcsb pdb:7DK7|rcsb pdb:7DMU|rcsb pdb:7JVB|rcsb pdb:7JWY|rcsb pdb:7K8M|rcsb pdb:7KJ2|rcsb pdb:7KJ3|rcsb pdb:7KJ4|rcsb pdb:7KJ5|rcsb pdb:7KKK|rcsb pdb:7KKL|rcsb pdb:7KL9|rcsb pdb:7KMB|rcsb pdb:7KMS|rcsb pdb:7KMZ|rcsb pdb:7KNB|rcsb pdb:7KNE|rcsb pdb:7KNH|rcsb pdb:7KNI|rcsb pdb:7L02|rcsb pdb:7L06|rcsb pdb:7L09|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR036326|rcsb pdb:6M17|rcsb pdb:6VSB|rcsb pdb:6VXX|rcsb pdb:6VYB|rcsb pdb:6LVN|rcsb pdb:6LXT|rcsb pdb:6M0J|rcsb pdb:6W41|interpro:IPR032500|interpro:IPR043607|rcsb pdb:6M1V|rcsb pdb:6WPS|rcsb pdb:6WPT|rcsb pdb:6X29|rcsb pdb:6X2A|rcsb pdb:6X2B|rcsb pdb:6X2C|rcsb pdb:6X6P|rcsb pdb:6XC2|rcsb pdb:6XC3|rcsb pdb:6XC4|rcsb pdb:6XC7|rcsb pdb:6XCM|rcsb pdb:6XCN|rcsb pdb:6XDG|rcsb pdb:6XE1|rcsb pdb:6XEY|rcsb pdb:6XKL|rcsb pdb:6XR8|rcsb pdb:6XRA|rcsb pdb:6XS6|rcsb pdb:6YZ5|rcsb pdb:6YZ7|rcsb pdb:6Z2M|rcsb pdb:6Z43|rcsb pdb:6ZCZ|rcsb pdb:6ZDH|rcsb pdb:6ZER|rcsb pdb:6ZFO|rcsb pdb:6ZGE|rcsb pdb:6ZGG|rcsb pdb:6ZGI|rcsb pdb:6ZOX|rcsb pdb:6ZOY|rcsb pdb:6ZOZ|rcsb pdb:6ZP0|rcsb pdb:6ZP1|rcsb pdb:6ZP2|rcsb pdb:7BWJ|rcsb pdb:7BYR|rcsb pdb:7C01|rcsb pdb:7C2L|rcsb pdb:7C8V|rcsb pdb:7C8W|rcsb pdb:7CAN|rcsb pdb:6X79|rcsb pdb:6XF5|rcsb pdb:6XF6|rcsb pdb:6XLU|rcsb pdb:6XM0|rcsb pdb:6XM3|rcsb pdb:6XM4|rcsb pdb:6XM5|rcsb pdb:6Z97|rcsb pdb:6ZBP|rcsb pdb:6ZDG|rcsb pdb:6ZH9|rcsb pdb:6ZHD|rcsb pdb:6ZOW|rcsb pdb:6ZP5|rcsb pdb:6ZP7|rcsb pdb:6ZWV|rcsb pdb:7C8D|rcsb pdb:7CAH|rcsb pdb:7CN9|rcsb pdb:7JJI|rcsb pdb:7JJJ|rcsb pdb:7JMO|rcsb pdb:7JMP|rcsb pdb:6XKP|rcsb pdb:6XKQ|rcsb pdb:6ZB4|rcsb pdb:6ZB5|rcsb pdb:6ZXN|rcsb pdb:7A29|rcsb pdb:7A4N|rcsb pdb:7A5R|rcsb pdb:7A5S|rcsb pdb:7A91|rcsb pdb:7A92|rcsb pdb:7A93|rcsb pdb:7A94|rcsb pdb:7A95|rcsb pdb:7A96|rcsb pdb:7A97|rcsb pdb:7A98|rcsb pdb:7AD1|rcsb pdb:7CAI|rcsb pdb:7CAK|rcsb pdb:7CH4|rcsb pdb:7CH5|rcsb pdb:7CHB|rcsb pdb:7CHC|rcsb pdb:7CHE|rcsb pdb:7CHF|rcsb pdb:7CHH|rcsb pdb:7JJC|rcsb pdb:7JMW|rcsb pdb:7JV2|rcsb pdb:7JV4|rcsb pdb:7JV6|rcsb pdb:7JVA|rcsb pdb:7JVC|rcsb pdb:7JW0|rcsb pdb:7JWB|rcsb pdb:7JX3|rcsb pdb:7JZL|rcsb pdb:7JZM|rcsb pdb:7JZN|rcsb pdb:7JZU|rcsb pdb:7K43|rcsb pdb:7K45|rcsb pdb:7K4N|rcsb pdb:7K8S|rcsb pdb:7K8T|rcsb pdb:7K8U|rcsb pdb:7K8V|rcsb pdb:7K8W|rcsb pdb:7K8X|rcsb pdb:7K8Y|rcsb pdb:7K8Z|rcsb pdb:7K90|rcsb pdb:7K9Z|rcsb pdb:7KDG|rcsb pdb:7KDH|rcsb pdb:7KDI|rcsb pdb:7KDJ|rcsb pdb:7KDK|rcsb pdb:7KDL|rcsb pdb:7KE4|rcsb pdb:7KE6|rcsb pdb:7KE7|rcsb pdb:7KE8|rcsb pdb:7KE9|rcsb pdb:7KEA|rcsb pdb:7KEB|rcsb pdb:7KEC|reactome:R-HSA-9694322|reactome:R-HSA-9694548|reactome:R-HSA-9694614|reactome:R-HSA-9694635	pubmed:19693543(see-also)|pubmed:12297042(see-also)|go:"GO:0034674"(integrin alpha5-beta1 complex)|complex portal:CPX-1794(complex-primary)|evidence ontology:"ECO:0000353"|intact:EBI-26987514(exp-evidence)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0035313"(wound healing, spreading of epidermal cells)	-	-	curated-complex:Cell adhesion, bi-directional signaling receptor which functions as a link between the extra-cellular matrix and the cytoskeleton. Receptor for fibronectin and fibrinogen which its binds via the sequence R-G-D in the ligand.|complex-properties:The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. The ligand-binding site forms in a region at the intersection of the integrin alpha-chain beta-propeller and the betaI domain, with the alpha chain being central in determining ligand specificity.|ligand:"Fibronectin (P02751)"|complex-assembly:Heterodimer	figure legend:1A|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/06/29	2020/12/07	rogid:QpTiyy2B+5c9PtFcZD+nZTX7nng2697049	-	-	false	sufficient binding region:319-541|his tag:c-c	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P0DTC2	uniprotkb:P02751	intact:EBI-25474821	intact:EBI-1220319|uniprotkb:Q7Z391|uniprotkb:O95609|uniprotkb:O95610|uniprotkb:Q14312|uniprotkb:Q14325|uniprotkb:Q14326|uniprotkb:Q17RV7|uniprotkb:Q585T2|uniprotkb:Q59EH1|uniprotkb:Q60FE4|uniprotkb:Q68DP8|uniprotkb:Q68DP9|uniprotkb:Q68DT4|uniprotkb:Q6LDP6|uniprotkb:Q6MZU5|uniprotkb:Q6N025|uniprotkb:Q6N0A6|uniprotkb:Q86T27|uniprotkb:Q8IVI8|uniprotkb:Q96KP7|uniprotkb:Q96KP8|uniprotkb:Q96KP9|uniprotkb:Q9H1B8|uniprotkb:Q9HAP3|uniprotkb:Q9UMK2|uniprotkb:Q6MZS0|uniprotkb:B7ZLF0|uniprotkb:E9PE77|uniprotkb:E9PG29|uniprotkb:Q564H7|uniprotkb:Q53S27|ensembl:ENSP00000346839	psi-mi:spike_sars2(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name)	psi-mi:finc_human(display_long)|uniprotkb:FN1(gene name)|psi-mi:FN1(display_short)|uniprotkb:FN(gene name synonym)|uniprotkb:Cold-insoluble globulin(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Beddingfield et al. (2020)	pubmed:33102950|imex:IM-28488	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26429778|imex:IM-28488-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR043002|interpro:IPR044873|rcsb pdb:7MJI|rcsb pdb:7MJJ|rcsb pdb:7MJK|rcsb pdb:7MJL|rcsb pdb:7MJM|rcsb pdb:7MJN|rcsb pdb:7MKB|rcsb pdb:7MKL|rcsb pdb:7MKM|rcsb pdb:7MMO|rcsb pdb:7MY2|rcsb pdb:7MY3|rcsb pdb:7N0G|rcsb pdb:7N0H|rcsb pdb:7NEG|rcsb pdb:7NKT|rcsb pdb:7NT9|rcsb pdb:7NTA|rcsb pdb:7NTC|rcsb pdb:7NX6|rcsb pdb:7NX7|rcsb pdb:7NX8|rcsb pdb:7NX9|rcsb pdb:7NXA|rcsb pdb:7NXB|rcsb pdb:7NXC|rcsb pdb:7AKD|rcsb pdb:7B14|rcsb pdb:7B18|rcsb pdb:7B62|rcsb pdb:7C53|rcsb pdb:7CHO|rcsb pdb:7CHP|rcsb pdb:7CHS|rcsb pdb:7CN4|rcsb pdb:7CWT|rcsb pdb:7CYH|rcsb pdb:7CYP|rcsb pdb:7CZP|rcsb pdb:7CZQ|rcsb pdb:7CZR|rcsb pdb:7CZS|rcsb pdb:7CZT|rcsb pdb:7CZU|rcsb pdb:7CZV|rcsb pdb:7CZW|rcsb pdb:7CZX|rcsb pdb:7CZY|rcsb pdb:7CZZ|rcsb pdb:7D00|rcsb pdb:7D03|rcsb pdb:7D0B|rcsb pdb:7D0C|rcsb pdb:7D0D|rcsb pdb:7D4G|rcsb pdb:7DEO|rcsb pdb:7DET|rcsb pdb:7DEU|interpro:IPR044874|rcsb pdb:7DJZ|rcsb pdb:7DK0|rcsb pdb:7DWX|rcsb pdb:7DWY|rcsb pdb:7DWZ|rcsb pdb:7DX0|rcsb pdb:7DX1|rcsb pdb:7DX2|rcsb pdb:7DX3|rcsb pdb:7DX4|rcsb pdb:7DX5|rcsb pdb:7DX6|rcsb pdb:7DX7|rcsb pdb:7DX8|rcsb pdb:7DX9|rcsb pdb:7DZW|rcsb pdb:7DZX|rcsb pdb:7DZY|rcsb pdb:7E23|rcsb pdb:7E3J|rcsb pdb:7E5Y|rcsb pdb:7E7B|rcsb pdb:7E7D|rcsb pdb:7E7X|rcsb pdb:7E7Y|rcsb pdb:7E86|rcsb pdb:7E88|rcsb pdb:7E8C|rcsb pdb:7E8F|rcsb pdb:7E8M|rcsb pdb:7EAM|rcsb pdb:7EAN|rcsb pdb:7EAZ|rcsb pdb:7EB0|rcsb pdb:7EB3|rcsb pdb:7EB4|rcsb pdb:7EB5|rcsb pdb:7EJ4|rcsb pdb:7EJ5|rcsb pdb:7EK6|rcsb pdb:7KFV|rcsb pdb:7KFW|rcsb pdb:7KFX|rcsb pdb:7KFY|rcsb pdb:7KQB|rcsb pdb:7KQE|rcsb pdb:7KRQ|rcsb pdb:7KRR|rcsb pdb:7KRS|rcsb pdb:7L2D|rcsb pdb:7L2E|rcsb pdb:7L2F|rcsb pdb:7L4Z|rcsb pdb:7L56|rcsb pdb:7L57|rcsb pdb:7L58|rcsb pdb:7LAA|rcsb pdb:7LAB|rcsb pdb:7LC8|rcsb pdb:7LDJ|rcsb pdb:7LJR|rcsb pdb:7LM8|rcsb pdb:7LO4|rcsb pdb:7LQV|rcsb pdb:7LQW|rcsb pdb:7LS9|rcsb pdb:7LSS|rcsb pdb:7LWI|rcsb pdb:7LWJ|rcsb pdb:7LWK|rcsb pdb:7LWL|rcsb pdb:7LWM|rcsb pdb:7LWN|rcsb pdb:7LWO|rcsb pdb:7LWP|rcsb pdb:7LWQ|rcsb pdb:7LWS|rcsb pdb:7LWT|rcsb pdb:7LWU|rcsb pdb:7LWV|rcsb pdb:7LWW|rcsb pdb:7LX5|rcsb pdb:7LXW|rcsb pdb:7LXX|rcsb pdb:7LXY|rcsb pdb:7LXZ|rcsb pdb:7LY0|rcsb pdb:7LY2|rcsb pdb:7LY3|rcsb pdb:7LYK|rcsb pdb:7LYL|rcsb pdb:7LYM|rcsb pdb:7LYN|rcsb pdb:7LYO|rcsb pdb:7LYP|rcsb pdb:7LYQ|rcsb pdb:7M0J|rcsb pdb:7M6D|rcsb pdb:7M6E|rcsb pdb:7M6F|rcsb pdb:7M6G|rcsb pdb:7M6H|rcsb pdb:7M6I|rcsb pdb:7M71|rcsb pdb:7M7B|rcsb pdb:7M7W|rcsb pdb:7M8J|rcsb pdb:7M8K|rcsb pdb:7M8S|rcsb pdb:7M8T|rcsb pdb:7M8U|rcsb pdb:7MF1|rcsb pdb:7MFU|rcsb pdb:7M3I|rcsb pdb:7M53|rcsb pdb:7MJG|rcsb pdb:7MJH|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|interpro:IPR043473|rcsb pdb:6LZG|rcsb pdb:6VW1|rcsb pdb:6YLA|rcsb pdb:6YM0|rcsb pdb:6YOR|rcsb pdb:7BZ5|refseq:YP_009724390.1|rcsb pdb:7KMG|rcsb pdb:7KMH|rcsb pdb:7KMI|rcsb pdb:7KMK|rcsb pdb:7KML|rcsb pdb:7KN5|rcsb pdb:7KN6|rcsb pdb:7KN7|rcsb pdb:7KS9|rcsb pdb:7KSG|rcsb pdb:7KXJ|rcsb pdb:7KXK|rcsb pdb:7KZB|rcsb pdb:7L0N|rcsb pdb:7L2C|rcsb pdb:7L3N|rcsb pdb:7L5B|rcsb pdb:7L7F|rcsb pdb:7L7K|rcsb pdb:7LCN|rcsb pdb:7LD1|rcsb pdb:7LOP|rcsb pdb:7ND3|rcsb pdb:7ND4|rcsb pdb:7ND5|rcsb pdb:7ND6|rcsb pdb:7ND7|rcsb pdb:7ND8|rcsb pdb:7ND9|rcsb pdb:7NDA|rcsb pdb:7NDB|rcsb pdb:7NDC|rcsb pdb:7NDD|rcsb pdb:7NEH|rcsb pdb:7B17|rcsb pdb:7BEH|rcsb pdb:7BEI|rcsb pdb:7BEJ|rcsb pdb:7BEK|rcsb pdb:7BEL|rcsb pdb:7BEM|rcsb pdb:7BEN|rcsb pdb:7BEO|rcsb pdb:7BEP|rcsb pdb:7C8J|rcsb pdb:7CAC|rcsb pdb:7CM4|rcsb pdb:7CWL|rcsb pdb:7D2Z|rcsb pdb:7D30|rcsb pdb:7DPM|rcsb pdb:7KGJ|rcsb pdb:7KGK|rcsb pdb:7KLG|rcsb pdb:7KLH|rcsb pdb:7KLW|interpro:IPR042578|rcsb pdb:7CAB|interpro:IPR044341|rcsb pdb:7CDI|interpro:IPR044366|rcsb pdb:7CDJ|rcsb pdb:6ZLR|rcsb pdb:7CJF|rcsb pdb:7CT5|rcsb pdb:7A25|rcsb pdb:7CWM|rcsb pdb:7CWN|rcsb pdb:7CWO|rcsb pdb:7CWS|rcsb pdb:7CWU|rcsb pdb:7DCC|rcsb pdb:7DCX|rcsb pdb:7DD2|rcsb pdb:7DD8|rcsb pdb:7DDD|rcsb pdb:7DDN|rcsb pdb:7DF3|rcsb pdb:7DF4|rcsb pdb:7DK3|rcsb pdb:7DK4|rcsb pdb:7DK5|rcsb pdb:7DK6|rcsb pdb:7DK7|rcsb pdb:7DMU|rcsb pdb:7JVB|rcsb pdb:7JWY|rcsb pdb:7K8M|rcsb pdb:7KJ2|rcsb pdb:7KJ3|rcsb pdb:7KJ4|rcsb pdb:7KJ5|rcsb pdb:7KKK|rcsb pdb:7KKL|rcsb pdb:7KL9|rcsb pdb:7KMB|rcsb pdb:7KMS|rcsb pdb:7KMZ|rcsb pdb:7KNB|rcsb pdb:7KNE|rcsb pdb:7KNH|rcsb pdb:7KNI|rcsb pdb:7L02|rcsb pdb:7L06|rcsb pdb:7L09|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR036326|rcsb pdb:6M17|rcsb pdb:6VSB|rcsb pdb:6VXX|rcsb pdb:6VYB|rcsb pdb:6LVN|rcsb pdb:6LXT|rcsb pdb:6M0J|rcsb pdb:6W41|interpro:IPR032500|interpro:IPR043607|rcsb pdb:6M1V|rcsb pdb:6WPS|rcsb pdb:6WPT|rcsb pdb:6X29|rcsb pdb:6X2A|rcsb pdb:6X2B|rcsb pdb:6X2C|rcsb pdb:6X6P|rcsb pdb:6XC2|rcsb pdb:6XC3|rcsb pdb:6XC4|rcsb pdb:6XC7|rcsb pdb:6XCM|rcsb pdb:6XCN|rcsb pdb:6XDG|rcsb pdb:6XE1|rcsb pdb:6XEY|rcsb pdb:6XKL|rcsb pdb:6XR8|rcsb pdb:6XRA|rcsb pdb:6XS6|rcsb pdb:6YZ5|rcsb pdb:6YZ7|rcsb pdb:6Z2M|rcsb pdb:6Z43|rcsb pdb:6ZCZ|rcsb pdb:6ZDH|rcsb pdb:6ZER|rcsb pdb:6ZFO|rcsb pdb:6ZGE|rcsb pdb:6ZGG|rcsb pdb:6ZGI|rcsb pdb:6ZOX|rcsb pdb:6ZOY|rcsb pdb:6ZOZ|rcsb pdb:6ZP0|rcsb pdb:6ZP1|rcsb pdb:6ZP2|rcsb pdb:7BWJ|rcsb pdb:7BYR|rcsb pdb:7C01|rcsb pdb:7C2L|rcsb pdb:7C8V|rcsb pdb:7C8W|rcsb pdb:7CAN|rcsb pdb:6X79|rcsb pdb:6XF5|rcsb pdb:6XF6|rcsb pdb:6XLU|rcsb pdb:6XM0|rcsb pdb:6XM3|rcsb pdb:6XM4|rcsb pdb:6XM5|rcsb pdb:6Z97|rcsb pdb:6ZBP|rcsb pdb:6ZDG|rcsb pdb:6ZH9|rcsb pdb:6ZHD|rcsb pdb:6ZOW|rcsb pdb:6ZP5|rcsb pdb:6ZP7|rcsb pdb:6ZWV|rcsb pdb:7C8D|rcsb pdb:7CAH|rcsb pdb:7CN9|rcsb pdb:7JJI|rcsb pdb:7JJJ|rcsb pdb:7JMO|rcsb pdb:7JMP|rcsb pdb:6XKP|rcsb pdb:6XKQ|rcsb pdb:6ZB4|rcsb pdb:6ZB5|rcsb pdb:6ZXN|rcsb pdb:7A29|rcsb pdb:7A4N|rcsb pdb:7A5R|rcsb pdb:7A5S|rcsb pdb:7A91|rcsb pdb:7A92|rcsb pdb:7A93|rcsb pdb:7A94|rcsb pdb:7A95|rcsb pdb:7A96|rcsb pdb:7A97|rcsb pdb:7A98|rcsb pdb:7AD1|rcsb pdb:7CAI|rcsb pdb:7CAK|rcsb pdb:7CH4|rcsb pdb:7CH5|rcsb pdb:7CHB|rcsb pdb:7CHC|rcsb pdb:7CHE|rcsb pdb:7CHF|rcsb pdb:7CHH|rcsb pdb:7JJC|rcsb pdb:7JMW|rcsb pdb:7JV2|rcsb pdb:7JV4|rcsb pdb:7JV6|rcsb pdb:7JVA|rcsb pdb:7JVC|rcsb pdb:7JW0|rcsb pdb:7JWB|rcsb pdb:7JX3|rcsb pdb:7JZL|rcsb pdb:7JZM|rcsb pdb:7JZN|rcsb pdb:7JZU|rcsb pdb:7K43|rcsb pdb:7K45|rcsb pdb:7K4N|rcsb pdb:7K8S|rcsb pdb:7K8T|rcsb pdb:7K8U|rcsb pdb:7K8V|rcsb pdb:7K8W|rcsb pdb:7K8X|rcsb pdb:7K8Y|rcsb pdb:7K8Z|rcsb pdb:7K90|rcsb pdb:7K9Z|rcsb pdb:7KDG|rcsb pdb:7KDH|rcsb pdb:7KDI|rcsb pdb:7KDJ|rcsb pdb:7KDK|rcsb pdb:7KDL|rcsb pdb:7KE4|rcsb pdb:7KE6|rcsb pdb:7KE7|rcsb pdb:7KE8|rcsb pdb:7KE9|rcsb pdb:7KEA|rcsb pdb:7KEB|rcsb pdb:7KEC|reactome:R-HSA-9694322|reactome:R-HSA-9694548|reactome:R-HSA-9694614|reactome:R-HSA-9694635	refseq:NP_002017.1|refseq:NP_473375.2|refseq:NP_997639.1|refseq:NP_997641.1|refseq:NP_997643.1|refseq:NP_997647.1|refseq:NP_001293058.1|refseq:NP_001293059.1|refseq:NP_001293060.1|refseq:NP_001293061.1|refseq:XP_005246463.1|dip:DIP-29547N|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019899"(enzyme binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0033622"(integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|ensembl:ENSG00000115414(gene)|ensembl:ENST00000354785(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006953"(acute-phase response)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|interpro:IPR000083(Fibronectin, type I)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036116|interpro:IPR036943|mint:P02751|rcsb pdb:1E88|rcsb pdb:1E8B|rcsb pdb:1FBR|rcsb pdb:1FNA|rcsb pdb:1FNF|rcsb pdb:1FNH|rcsb pdb:1J8K|rcsb pdb:1O9A|rcsb pdb:1OWW|rcsb pdb:1Q38|rcsb pdb:1QGB|rcsb pdb:1QO6|rcsb pdb:1TTF|rcsb pdb:1TTG|rcsb pdb:2CG6|rcsb pdb:2CG7|rcsb pdb:2CK2|rcsb pdb:2CKU|rcsb pdb:2EC3|rcsb pdb:2FN2|rcsb pdb:2FNB|rcsb pdb:2GEE|rcsb pdb:2H41|rcsb pdb:2H45|rcsb pdb:2HA1|rcsb pdb:2MNU|rcsb pdb:2N1K|rcsb pdb:2OCF|rcsb pdb:2RKY|rcsb pdb:2RKZ|rcsb pdb:2RL0|rcsb pdb:3CAL|rcsb pdb:3EJH|rcsb pdb:3GXE|rcsb pdb:3M7P|rcsb pdb:3MQL|rcsb pdb:3R8Q|rcsb pdb:3T1W|rcsb pdb:3ZRZ|rcsb pdb:4GH7|rcsb pdb:4JE4|rcsb pdb:4JEG|rcsb pdb:4LXO|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|rcsb pdb:4PZ5|rcsb pdb:5DC0|rcsb pdb:5DC4|rcsb pdb:5DC9|rcsb pdb:5DFT|rcsb pdb:5J6Z|rcsb pdb:5J7C|rcsb pdb:5M0A|rcsb pdb:5N47|rcsb pdb:5N48|rcsb pdb:6HNF|rcsb pdb:6MFA|rcsb pdb:6MSV|rcsb pdb:6NAJ|rcsb pdb:6XAX|rcsb pdb:6XAY|rcsb pdb:7NWL|reactome:R-HSA-114608|reactome:R-HSA-1474228|reactome:R-HSA-1474244|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381426|reactome:R-HSA-5674135|reactome:R-HSA-6785807|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8874081|reactome:R-HSA-8957275|reactome:R-HSA-9649948|reactome:R-HSA-9656223	-	-	-	figure legend:1A|comment:There is an U-shaped dose-response curve for ATN-161.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/06/29	2020/12/07	rogid:QpTiyy2B+5c9PtFcZD+nZTX7nng2697049	rogid:4arZu49X8b+dthqaX4DIh59V8h09606	-	false	sufficient binding region:319-541|his tag:c-c	N-acetyl-L-proline:1498-1498|sufficient binding region:1498-1502|mutation:1501-1501	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P0DTC2	chembl target:CHEMBL2095226	intact:EBI-25474821	intact:EBI-2550721|reactome:R-HSA-202730|matrixdb:MULT_15_human|wwpdb:3vi3|signor:SIGNOR-C163	psi-mi:spike_sars2(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name)	psi-mi:intg_a5_b1_human(display_short)|psi-mi:CHEMBL2095226(display_long)|intact:alpha-5/beta-1 integrin complex(complex synonym)|intact:alpha5-beta1 integrin complex(complex synonym)|intact:"ITGA5:ITGB1"(complex systematic name)|intact:Integrin alpha5-beta1 complex(complex recommended name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Beddingfield et al. (2020)	pubmed:33102950|imex:IM-28488	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26429778|imex:IM-28488-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	interpro:IPR043002|interpro:IPR044873|rcsb pdb:7MJI|rcsb pdb:7MJJ|rcsb pdb:7MJK|rcsb pdb:7MJL|rcsb pdb:7MJM|rcsb pdb:7MJN|rcsb pdb:7MKB|rcsb pdb:7MKL|rcsb pdb:7MKM|rcsb pdb:7MMO|rcsb pdb:7MY2|rcsb pdb:7MY3|rcsb pdb:7N0G|rcsb pdb:7N0H|rcsb pdb:7NEG|rcsb pdb:7NKT|rcsb pdb:7NT9|rcsb pdb:7NTA|rcsb pdb:7NTC|rcsb pdb:7NX6|rcsb pdb:7NX7|rcsb pdb:7NX8|rcsb pdb:7NX9|rcsb pdb:7NXA|rcsb pdb:7NXB|rcsb pdb:7NXC|rcsb pdb:7AKD|rcsb pdb:7B14|rcsb pdb:7B18|rcsb pdb:7B62|rcsb pdb:7C53|rcsb pdb:7CHO|rcsb pdb:7CHP|rcsb pdb:7CHS|rcsb pdb:7CN4|rcsb pdb:7CWT|rcsb pdb:7CYH|rcsb pdb:7CYP|rcsb pdb:7CZP|rcsb pdb:7CZQ|rcsb pdb:7CZR|rcsb pdb:7CZS|rcsb pdb:7CZT|rcsb pdb:7CZU|rcsb pdb:7CZV|rcsb pdb:7CZW|rcsb pdb:7CZX|rcsb pdb:7CZY|rcsb pdb:7CZZ|rcsb pdb:7D00|rcsb pdb:7D03|rcsb pdb:7D0B|rcsb pdb:7D0C|rcsb pdb:7D0D|rcsb pdb:7D4G|rcsb pdb:7DEO|rcsb pdb:7DET|rcsb pdb:7DEU|interpro:IPR044874|rcsb pdb:7DJZ|rcsb pdb:7DK0|rcsb pdb:7DWX|rcsb pdb:7DWY|rcsb pdb:7DWZ|rcsb pdb:7DX0|rcsb pdb:7DX1|rcsb pdb:7DX2|rcsb pdb:7DX3|rcsb pdb:7DX4|rcsb pdb:7DX5|rcsb pdb:7DX6|rcsb pdb:7DX7|rcsb pdb:7DX8|rcsb pdb:7DX9|rcsb pdb:7DZW|rcsb pdb:7DZX|rcsb pdb:7DZY|rcsb pdb:7E23|rcsb pdb:7E3J|rcsb pdb:7E5Y|rcsb pdb:7E7B|rcsb pdb:7E7D|rcsb pdb:7E7X|rcsb pdb:7E7Y|rcsb pdb:7E86|rcsb pdb:7E88|rcsb pdb:7E8C|rcsb pdb:7E8F|rcsb pdb:7E8M|rcsb pdb:7EAM|rcsb pdb:7EAN|rcsb pdb:7EAZ|rcsb pdb:7EB0|rcsb pdb:7EB3|rcsb pdb:7EB4|rcsb pdb:7EB5|rcsb pdb:7EJ4|rcsb pdb:7EJ5|rcsb pdb:7EK6|rcsb pdb:7KFV|rcsb pdb:7KFW|rcsb pdb:7KFX|rcsb pdb:7KFY|rcsb pdb:7KQB|rcsb pdb:7KQE|rcsb pdb:7KRQ|rcsb pdb:7KRR|rcsb pdb:7KRS|rcsb pdb:7L2D|rcsb pdb:7L2E|rcsb pdb:7L2F|rcsb pdb:7L4Z|rcsb pdb:7L56|rcsb pdb:7L57|rcsb pdb:7L58|rcsb pdb:7LAA|rcsb pdb:7LAB|rcsb pdb:7LC8|rcsb pdb:7LDJ|rcsb pdb:7LJR|rcsb pdb:7LM8|rcsb pdb:7LO4|rcsb pdb:7LQV|rcsb pdb:7LQW|rcsb pdb:7LS9|rcsb pdb:7LSS|rcsb pdb:7LWI|rcsb pdb:7LWJ|rcsb pdb:7LWK|rcsb pdb:7LWL|rcsb pdb:7LWM|rcsb pdb:7LWN|rcsb pdb:7LWO|rcsb pdb:7LWP|rcsb pdb:7LWQ|rcsb pdb:7LWS|rcsb pdb:7LWT|rcsb pdb:7LWU|rcsb pdb:7LWV|rcsb pdb:7LWW|rcsb pdb:7LX5|rcsb pdb:7LXW|rcsb pdb:7LXX|rcsb pdb:7LXY|rcsb pdb:7LXZ|rcsb pdb:7LY0|rcsb pdb:7LY2|rcsb pdb:7LY3|rcsb pdb:7LYK|rcsb pdb:7LYL|rcsb pdb:7LYM|rcsb pdb:7LYN|rcsb pdb:7LYO|rcsb pdb:7LYP|rcsb pdb:7LYQ|rcsb pdb:7M0J|rcsb pdb:7M6D|rcsb pdb:7M6E|rcsb pdb:7M6F|rcsb pdb:7M6G|rcsb pdb:7M6H|rcsb pdb:7M6I|rcsb pdb:7M71|rcsb pdb:7M7B|rcsb pdb:7M7W|rcsb pdb:7M8J|rcsb pdb:7M8K|rcsb pdb:7M8S|rcsb pdb:7M8T|rcsb pdb:7M8U|rcsb pdb:7MF1|rcsb pdb:7MFU|rcsb pdb:7M3I|rcsb pdb:7M53|rcsb pdb:7MJG|rcsb pdb:7MJH|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|interpro:IPR043473|rcsb pdb:6LZG|rcsb pdb:6VW1|rcsb pdb:6YLA|rcsb pdb:6YM0|rcsb pdb:6YOR|rcsb pdb:7BZ5|refseq:YP_009724390.1|rcsb pdb:7KMG|rcsb pdb:7KMH|rcsb pdb:7KMI|rcsb pdb:7KMK|rcsb pdb:7KML|rcsb pdb:7KN5|rcsb pdb:7KN6|rcsb pdb:7KN7|rcsb pdb:7KS9|rcsb pdb:7KSG|rcsb pdb:7KXJ|rcsb pdb:7KXK|rcsb pdb:7KZB|rcsb pdb:7L0N|rcsb pdb:7L2C|rcsb pdb:7L3N|rcsb pdb:7L5B|rcsb pdb:7L7F|rcsb pdb:7L7K|rcsb pdb:7LCN|rcsb pdb:7LD1|rcsb pdb:7LOP|rcsb pdb:7ND3|rcsb pdb:7ND4|rcsb pdb:7ND5|rcsb pdb:7ND6|rcsb pdb:7ND7|rcsb pdb:7ND8|rcsb pdb:7ND9|rcsb pdb:7NDA|rcsb pdb:7NDB|rcsb pdb:7NDC|rcsb pdb:7NDD|rcsb pdb:7NEH|rcsb pdb:7B17|rcsb pdb:7BEH|rcsb pdb:7BEI|rcsb pdb:7BEJ|rcsb pdb:7BEK|rcsb pdb:7BEL|rcsb pdb:7BEM|rcsb pdb:7BEN|rcsb pdb:7BEO|rcsb pdb:7BEP|rcsb pdb:7C8J|rcsb pdb:7CAC|rcsb pdb:7CM4|rcsb pdb:7CWL|rcsb pdb:7D2Z|rcsb pdb:7D30|rcsb pdb:7DPM|rcsb pdb:7KGJ|rcsb pdb:7KGK|rcsb pdb:7KLG|rcsb pdb:7KLH|rcsb pdb:7KLW|interpro:IPR042578|rcsb pdb:7CAB|interpro:IPR044341|rcsb pdb:7CDI|interpro:IPR044366|rcsb pdb:7CDJ|rcsb pdb:6ZLR|rcsb pdb:7CJF|rcsb pdb:7CT5|rcsb pdb:7A25|rcsb pdb:7CWM|rcsb pdb:7CWN|rcsb pdb:7CWO|rcsb pdb:7CWS|rcsb pdb:7CWU|rcsb pdb:7DCC|rcsb pdb:7DCX|rcsb pdb:7DD2|rcsb pdb:7DD8|rcsb pdb:7DDD|rcsb pdb:7DDN|rcsb pdb:7DF3|rcsb pdb:7DF4|rcsb pdb:7DK3|rcsb pdb:7DK4|rcsb pdb:7DK5|rcsb pdb:7DK6|rcsb pdb:7DK7|rcsb pdb:7DMU|rcsb pdb:7JVB|rcsb pdb:7JWY|rcsb pdb:7K8M|rcsb pdb:7KJ2|rcsb pdb:7KJ3|rcsb pdb:7KJ4|rcsb pdb:7KJ5|rcsb pdb:7KKK|rcsb pdb:7KKL|rcsb pdb:7KL9|rcsb pdb:7KMB|rcsb pdb:7KMS|rcsb pdb:7KMZ|rcsb pdb:7KNB|rcsb pdb:7KNE|rcsb pdb:7KNH|rcsb pdb:7KNI|rcsb pdb:7L02|rcsb pdb:7L06|rcsb pdb:7L09|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR036326|rcsb pdb:6M17|rcsb pdb:6VSB|rcsb pdb:6VXX|rcsb pdb:6VYB|rcsb pdb:6LVN|rcsb pdb:6LXT|rcsb pdb:6M0J|rcsb pdb:6W41|interpro:IPR032500|interpro:IPR043607|rcsb pdb:6M1V|rcsb pdb:6WPS|rcsb pdb:6WPT|rcsb pdb:6X29|rcsb pdb:6X2A|rcsb pdb:6X2B|rcsb pdb:6X2C|rcsb pdb:6X6P|rcsb pdb:6XC2|rcsb pdb:6XC3|rcsb pdb:6XC4|rcsb pdb:6XC7|rcsb pdb:6XCM|rcsb pdb:6XCN|rcsb pdb:6XDG|rcsb pdb:6XE1|rcsb pdb:6XEY|rcsb pdb:6XKL|rcsb pdb:6XR8|rcsb pdb:6XRA|rcsb pdb:6XS6|rcsb pdb:6YZ5|rcsb pdb:6YZ7|rcsb pdb:6Z2M|rcsb pdb:6Z43|rcsb pdb:6ZCZ|rcsb pdb:6ZDH|rcsb pdb:6ZER|rcsb pdb:6ZFO|rcsb pdb:6ZGE|rcsb pdb:6ZGG|rcsb pdb:6ZGI|rcsb pdb:6ZOX|rcsb pdb:6ZOY|rcsb pdb:6ZOZ|rcsb pdb:6ZP0|rcsb pdb:6ZP1|rcsb pdb:6ZP2|rcsb pdb:7BWJ|rcsb pdb:7BYR|rcsb pdb:7C01|rcsb pdb:7C2L|rcsb pdb:7C8V|rcsb pdb:7C8W|rcsb pdb:7CAN|rcsb pdb:6X79|rcsb pdb:6XF5|rcsb pdb:6XF6|rcsb pdb:6XLU|rcsb pdb:6XM0|rcsb pdb:6XM3|rcsb pdb:6XM4|rcsb pdb:6XM5|rcsb pdb:6Z97|rcsb pdb:6ZBP|rcsb pdb:6ZDG|rcsb pdb:6ZH9|rcsb pdb:6ZHD|rcsb pdb:6ZOW|rcsb pdb:6ZP5|rcsb pdb:6ZP7|rcsb pdb:6ZWV|rcsb pdb:7C8D|rcsb pdb:7CAH|rcsb pdb:7CN9|rcsb pdb:7JJI|rcsb pdb:7JJJ|rcsb pdb:7JMO|rcsb pdb:7JMP|rcsb pdb:6XKP|rcsb pdb:6XKQ|rcsb pdb:6ZB4|rcsb pdb:6ZB5|rcsb pdb:6ZXN|rcsb pdb:7A29|rcsb pdb:7A4N|rcsb pdb:7A5R|rcsb pdb:7A5S|rcsb pdb:7A91|rcsb pdb:7A92|rcsb pdb:7A93|rcsb pdb:7A94|rcsb pdb:7A95|rcsb pdb:7A96|rcsb pdb:7A97|rcsb pdb:7A98|rcsb pdb:7AD1|rcsb pdb:7CAI|rcsb pdb:7CAK|rcsb pdb:7CH4|rcsb pdb:7CH5|rcsb pdb:7CHB|rcsb pdb:7CHC|rcsb pdb:7CHE|rcsb pdb:7CHF|rcsb pdb:7CHH|rcsb pdb:7JJC|rcsb pdb:7JMW|rcsb pdb:7JV2|rcsb pdb:7JV4|rcsb pdb:7JV6|rcsb pdb:7JVA|rcsb pdb:7JVC|rcsb pdb:7JW0|rcsb pdb:7JWB|rcsb pdb:7JX3|rcsb pdb:7JZL|rcsb pdb:7JZM|rcsb pdb:7JZN|rcsb pdb:7JZU|rcsb pdb:7K43|rcsb pdb:7K45|rcsb pdb:7K4N|rcsb pdb:7K8S|rcsb pdb:7K8T|rcsb pdb:7K8U|rcsb pdb:7K8V|rcsb pdb:7K8W|rcsb pdb:7K8X|rcsb pdb:7K8Y|rcsb pdb:7K8Z|rcsb pdb:7K90|rcsb pdb:7K9Z|rcsb pdb:7KDG|rcsb pdb:7KDH|rcsb pdb:7KDI|rcsb pdb:7KDJ|rcsb pdb:7KDK|rcsb pdb:7KDL|rcsb pdb:7KE4|rcsb pdb:7KE6|rcsb pdb:7KE7|rcsb pdb:7KE8|rcsb pdb:7KE9|rcsb pdb:7KEA|rcsb pdb:7KEB|rcsb pdb:7KEC|reactome:R-HSA-9694322|reactome:R-HSA-9694548|reactome:R-HSA-9694614|reactome:R-HSA-9694635	pubmed:19693543(see-also)|pubmed:12297042(see-also)|go:"GO:0034674"(integrin alpha5-beta1 complex)|complex portal:CPX-1794(complex-primary)|evidence ontology:"ECO:0000353"|intact:EBI-26987514(exp-evidence)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0035313"(wound healing, spreading of epidermal cells)	-	-	curated-complex:Cell adhesion, bi-directional signaling receptor which functions as a link between the extra-cellular matrix and the cytoskeleton. Receptor for fibronectin and fibrinogen which its binds via the sequence R-G-D in the ligand.|complex-properties:The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. The ligand-binding site forms in a region at the intersection of the integrin alpha-chain beta-propeller and the betaI domain, with the alpha chain being central in determining ligand specificity.|ligand:"Fibronectin (P02751)"|complex-assembly:Heterodimer	figure legend:1A|comment:There is an U-shaped dose-response curve for ATN-161.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/06/29	2020/12/07	rogid:QpTiyy2B+5c9PtFcZD+nZTX7nng2697049	-	-	false	sufficient binding region:319-541|his tag:c-c	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P02751	chembl target:CHEMBL2095226	intact:EBI-1220319|uniprotkb:Q7Z391|uniprotkb:O95609|uniprotkb:O95610|uniprotkb:Q14312|uniprotkb:Q14325|uniprotkb:Q14326|uniprotkb:Q17RV7|uniprotkb:Q585T2|uniprotkb:Q59EH1|uniprotkb:Q60FE4|uniprotkb:Q68DP8|uniprotkb:Q68DP9|uniprotkb:Q68DT4|uniprotkb:Q6LDP6|uniprotkb:Q6MZU5|uniprotkb:Q6N025|uniprotkb:Q6N0A6|uniprotkb:Q86T27|uniprotkb:Q8IVI8|uniprotkb:Q96KP7|uniprotkb:Q96KP8|uniprotkb:Q96KP9|uniprotkb:Q9H1B8|uniprotkb:Q9HAP3|uniprotkb:Q9UMK2|uniprotkb:Q6MZS0|uniprotkb:B7ZLF0|uniprotkb:E9PE77|uniprotkb:E9PG29|uniprotkb:Q564H7|uniprotkb:Q53S27|ensembl:ENSP00000346839	intact:EBI-2550721|reactome:R-HSA-202730|matrixdb:MULT_15_human|wwpdb:3vi3|signor:SIGNOR-C163	psi-mi:finc_human(display_long)|uniprotkb:FN1(gene name)|psi-mi:FN1(display_short)|uniprotkb:FN(gene name synonym)|uniprotkb:Cold-insoluble globulin(gene name synonym)	psi-mi:intg_a5_b1_human(display_short)|psi-mi:CHEMBL2095226(display_long)|intact:alpha-5/beta-1 integrin complex(complex synonym)|intact:alpha5-beta1 integrin complex(complex synonym)|intact:"ITGA5:ITGB1"(complex systematic name)|intact:Integrin alpha5-beta1 complex(complex recommended name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Beddingfield et al. (2020)	pubmed:33102950|imex:IM-28488	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26429794|imex:IM-28488-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	refseq:NP_002017.1|refseq:NP_473375.2|refseq:NP_997639.1|refseq:NP_997641.1|refseq:NP_997643.1|refseq:NP_997647.1|refseq:NP_001293058.1|refseq:NP_001293059.1|refseq:NP_001293060.1|refseq:NP_001293061.1|refseq:XP_005246463.1|dip:DIP-29547N|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019899"(enzyme binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0033622"(integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|ensembl:ENSG00000115414(gene)|ensembl:ENST00000354785(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006953"(acute-phase response)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|interpro:IPR000083(Fibronectin, type I)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036116|interpro:IPR036943|mint:P02751|rcsb pdb:1E88|rcsb pdb:1E8B|rcsb pdb:1FBR|rcsb pdb:1FNA|rcsb pdb:1FNF|rcsb pdb:1FNH|rcsb pdb:1J8K|rcsb pdb:1O9A|rcsb pdb:1OWW|rcsb pdb:1Q38|rcsb pdb:1QGB|rcsb pdb:1QO6|rcsb pdb:1TTF|rcsb pdb:1TTG|rcsb pdb:2CG6|rcsb pdb:2CG7|rcsb pdb:2CK2|rcsb pdb:2CKU|rcsb pdb:2EC3|rcsb pdb:2FN2|rcsb pdb:2FNB|rcsb pdb:2GEE|rcsb pdb:2H41|rcsb pdb:2H45|rcsb pdb:2HA1|rcsb pdb:2MNU|rcsb pdb:2N1K|rcsb pdb:2OCF|rcsb pdb:2RKY|rcsb pdb:2RKZ|rcsb pdb:2RL0|rcsb pdb:3CAL|rcsb pdb:3EJH|rcsb pdb:3GXE|rcsb pdb:3M7P|rcsb pdb:3MQL|rcsb pdb:3R8Q|rcsb pdb:3T1W|rcsb pdb:3ZRZ|rcsb pdb:4GH7|rcsb pdb:4JE4|rcsb pdb:4JEG|rcsb pdb:4LXO|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|rcsb pdb:4PZ5|rcsb pdb:5DC0|rcsb pdb:5DC4|rcsb pdb:5DC9|rcsb pdb:5DFT|rcsb pdb:5J6Z|rcsb pdb:5J7C|rcsb pdb:5M0A|rcsb pdb:5N47|rcsb pdb:5N48|rcsb pdb:6HNF|rcsb pdb:6MFA|rcsb pdb:6MSV|rcsb pdb:6NAJ|rcsb pdb:6XAX|rcsb pdb:6XAY|rcsb pdb:7NWL|reactome:R-HSA-114608|reactome:R-HSA-1474228|reactome:R-HSA-1474244|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381426|reactome:R-HSA-5674135|reactome:R-HSA-6785807|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8874081|reactome:R-HSA-8957275|reactome:R-HSA-9649948|reactome:R-HSA-9656223	pubmed:19693543(see-also)|pubmed:12297042(see-also)|go:"GO:0034674"(integrin alpha5-beta1 complex)|complex portal:CPX-1794(complex-primary)|evidence ontology:"ECO:0000353"|intact:EBI-26987514(exp-evidence)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0035313"(wound healing, spreading of epidermal cells)	-	-	curated-complex:Cell adhesion, bi-directional signaling receptor which functions as a link between the extra-cellular matrix and the cytoskeleton. Receptor for fibronectin and fibrinogen which its binds via the sequence R-G-D in the ligand.|complex-properties:The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. The ligand-binding site forms in a region at the intersection of the integrin alpha-chain beta-propeller and the betaI domain, with the alpha chain being central in determining ligand specificity.|ligand:"Fibronectin (P02751)"|complex-assembly:Heterodimer	figure legend:1A|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/06/29	2020/10/28	rogid:4arZu49X8b+dthqaX4DIh59V8h09606	-	-	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9BYF1	chembl target:CHEMBL2095226	intact:EBI-7730807|ensembl:ENSP00000252519|ensembl:ENSP00000389326|ensembl:ENSP00000504103|ensembl:ENSP00000505992|intact:EBI-25767352|uniprotkb:Q9UFZ6|uniprotkb:Q9NRA7|intact:MINT-4538816|uniprotkb:C7ECU1|uniprotkb:Q6UWP0|uniprotkb:Q86WT0|uniprotkb:A0A7D6JAD5|intact:EBI-15814450	intact:EBI-2550721|reactome:R-HSA-202730|matrixdb:MULT_15_human|wwpdb:3vi3|signor:SIGNOR-C163	psi-mi:ace2_human(display_long)|uniprotkb:ACE2(gene name)|psi-mi:ACE2(display_short)|uniprotkb:UNQ868/PRO1885(orf name)|uniprotkb:Angiotensin-converting enzyme homolog(gene name synonym)|uniprotkb:Metalloprotease MPROT15(gene name synonym)|uniprotkb:Angiotensin-converting enzyme-related carboxypeptidase(gene name synonym)	psi-mi:intg_a5_b1_human(display_short)|psi-mi:CHEMBL2095226(display_long)|intact:alpha-5/beta-1 integrin complex(complex synonym)|intact:alpha5-beta1 integrin complex(complex synonym)|intact:"ITGA5:ITGB1"(complex systematic name)|intact:Integrin alpha5-beta1 complex(complex recommended name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Beddingfield et al. (2020)	pubmed:33102950|imex:IM-28488	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26429810|imex:IM-28488-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	ensembl:ENST00000252519(transcript)|ensembl:ENST00000427411(transcript)|ensembl:ENST00000678073(transcript)|ensembl:ENST00000680121(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0003051"(angiotensin-mediated drinking behavior)|go:"GO:0003081"(regulation of systemic arterial blood pressure by renin-angiotensin)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004180"(carboxypeptidase activity)|go:"GO:0004181"(metallocarboxypeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006508"(proteolysis)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008241"(peptidyl-dipeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0015827"(tryptophan transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|ensembl:ENSG00000130234(gene)|go:"GO:0051957"(positive regulation of amino acid transport)|go:"GO:0060452"(positive regulation of cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1905737"(positive regulation of L-proline import across plasma membrane)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR001548(Peptidase M2, peptidyl-dipeptidase A)|interpro:IPR031588|mint:Q9BYF1|rcsb pdb:1R42|rcsb pdb:1R4L|rcsb pdb:1XJP|rcsb pdb:2AJF|rcsb pdb:3D0G|rcsb pdb:3D0H|rcsb pdb:3D0I|rcsb pdb:3KBH|rcsb pdb:3SCI|rcsb pdb:3SCJ|rcsb pdb:3SCK|rcsb pdb:3SCL|rcsb pdb:6ACG|rcsb pdb:6ACJ|rcsb pdb:6ACK|rcsb pdb:6CS2|rcsb pdb:6LZG|rcsb pdb:6M0J|rcsb pdb:6M17|rcsb pdb:6M18|go:"GO:0050727"(regulation of inflammatory response)|rcsb pdb:6M1D|rcsb pdb:6VW1|rcsb pdb:7A91|rcsb pdb:7A92|rcsb pdb:7A94|rcsb pdb:7A95|rcsb pdb:7A96|rcsb pdb:7A97|rcsb pdb:7A98|rcsb pdb:7BH9|rcsb pdb:7CT5|rcsb pdb:7DDO|rcsb pdb:7DDP|rcsb pdb:7DF4|rcsb pdb:7DMU|rcsb pdb:7DWX|rcsb pdb:7DX4|rcsb pdb:7DX5|rcsb pdb:7DX6|rcsb pdb:7DX7|rcsb pdb:7DX8|rcsb pdb:7DX9|rcsb pdb:7JVO|rcsb pdb:7KJ2|rcsb pdb:7KJ3|rcsb pdb:7KJ4|rcsb pdb:7KMB|rcsb pdb:7KMS|rcsb pdb:7KMZ|rcsb pdb:7KNB|rcsb pdb:7KNE|rcsb pdb:7KNH|rcsb pdb:7L0N|rcsb pdb:7L7F|rcsb pdb:7LO4|rcsb pdb:7MJM|rcsb pdb:7MJN|rcsb pdb:7NXC|reactome:R-HSA-2022377|reactome:R-HSA-9678110|reactome:R-HSA-9679191|reactome:R-HSA-9694614|rcsb pdb:7KNI|dip:DIP-44689N|refseq:NP_068576.1	pubmed:19693543(see-also)|pubmed:12297042(see-also)|go:"GO:0034674"(integrin alpha5-beta1 complex)|complex portal:CPX-1794(complex-primary)|evidence ontology:"ECO:0000353"|intact:EBI-26987514(exp-evidence)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0035313"(wound healing, spreading of epidermal cells)	-	comment:mint|function:Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses	curated-complex:Cell adhesion, bi-directional signaling receptor which functions as a link between the extra-cellular matrix and the cytoskeleton. Receptor for fibronectin and fibrinogen which its binds via the sequence R-G-D in the ligand.|complex-properties:The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. The ligand-binding site forms in a region at the intersection of the integrin alpha-chain beta-propeller and the betaI domain, with the alpha chain being central in determining ligand specificity.|ligand:"Fibronectin (P02751)"|complex-assembly:Heterodimer	figure legend:1B|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/06/29	2020/10/28	rogid:ZxuR6gzxz4Ns+hYH5uksGdn8S7o9606	-	-	false	fc-igg tag:c-c|sufficient binding region:1..18-740	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chembl target:CHEMBL2095226	uniprotkb:Q9BYF1	intact:EBI-2550721|reactome:R-HSA-202730|matrixdb:MULT_15_human|wwpdb:3vi3|signor:SIGNOR-C163	intact:EBI-7730807|ensembl:ENSP00000252519|ensembl:ENSP00000389326|ensembl:ENSP00000504103|ensembl:ENSP00000505992|intact:EBI-25767352|uniprotkb:Q9UFZ6|uniprotkb:Q9NRA7|intact:MINT-4538816|uniprotkb:C7ECU1|uniprotkb:Q6UWP0|uniprotkb:Q86WT0|uniprotkb:A0A7D6JAD5|intact:EBI-15814450	psi-mi:intg_a5_b1_human(display_short)|psi-mi:CHEMBL2095226(display_long)|intact:alpha-5/beta-1 integrin complex(complex synonym)|intact:alpha5-beta1 integrin complex(complex synonym)|intact:"ITGA5:ITGB1"(complex systematic name)|intact:Integrin alpha5-beta1 complex(complex recommended name)	psi-mi:ace2_human(display_long)|uniprotkb:ACE2(gene name)|psi-mi:ACE2(display_short)|uniprotkb:UNQ868/PRO1885(orf name)|uniprotkb:Angiotensin-converting enzyme homolog(gene name synonym)|uniprotkb:Metalloprotease MPROT15(gene name synonym)|uniprotkb:Angiotensin-converting enzyme-related carboxypeptidase(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Beddingfield et al. (2020)	pubmed:33102950|imex:IM-28488	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26429818|imex:IM-28488-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	pubmed:19693543(see-also)|pubmed:12297042(see-also)|go:"GO:0034674"(integrin alpha5-beta1 complex)|complex portal:CPX-1794(complex-primary)|evidence ontology:"ECO:0000353"|intact:EBI-26987514(exp-evidence)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0035313"(wound healing, spreading of epidermal cells)	ensembl:ENST00000252519(transcript)|ensembl:ENST00000427411(transcript)|ensembl:ENST00000678073(transcript)|ensembl:ENST00000680121(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0003051"(angiotensin-mediated drinking behavior)|go:"GO:0003081"(regulation of systemic arterial blood pressure by renin-angiotensin)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004180"(carboxypeptidase activity)|go:"GO:0004181"(metallocarboxypeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006508"(proteolysis)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008241"(peptidyl-dipeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0015827"(tryptophan transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|ensembl:ENSG00000130234(gene)|go:"GO:0051957"(positive regulation of amino acid transport)|go:"GO:0060452"(positive regulation of cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1905737"(positive regulation of L-proline import across plasma membrane)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR001548(Peptidase M2, peptidyl-dipeptidase A)|interpro:IPR031588|mint:Q9BYF1|rcsb pdb:1R42|rcsb pdb:1R4L|rcsb pdb:1XJP|rcsb pdb:2AJF|rcsb pdb:3D0G|rcsb pdb:3D0H|rcsb pdb:3D0I|rcsb pdb:3KBH|rcsb pdb:3SCI|rcsb pdb:3SCJ|rcsb pdb:3SCK|rcsb pdb:3SCL|rcsb pdb:6ACG|rcsb pdb:6ACJ|rcsb pdb:6ACK|rcsb pdb:6CS2|rcsb pdb:6LZG|rcsb pdb:6M0J|rcsb pdb:6M17|rcsb pdb:6M18|go:"GO:0050727"(regulation of inflammatory response)|rcsb pdb:6M1D|rcsb pdb:6VW1|rcsb pdb:7A91|rcsb pdb:7A92|rcsb pdb:7A94|rcsb pdb:7A95|rcsb pdb:7A96|rcsb pdb:7A97|rcsb pdb:7A98|rcsb pdb:7BH9|rcsb pdb:7CT5|rcsb pdb:7DDO|rcsb pdb:7DDP|rcsb pdb:7DF4|rcsb pdb:7DMU|rcsb pdb:7DWX|rcsb pdb:7DX4|rcsb pdb:7DX5|rcsb pdb:7DX6|rcsb pdb:7DX7|rcsb pdb:7DX8|rcsb pdb:7DX9|rcsb pdb:7JVO|rcsb pdb:7KJ2|rcsb pdb:7KJ3|rcsb pdb:7KJ4|rcsb pdb:7KMB|rcsb pdb:7KMS|rcsb pdb:7KMZ|rcsb pdb:7KNB|rcsb pdb:7KNE|rcsb pdb:7KNH|rcsb pdb:7L0N|rcsb pdb:7L7F|rcsb pdb:7LO4|rcsb pdb:7MJM|rcsb pdb:7MJN|rcsb pdb:7NXC|reactome:R-HSA-2022377|reactome:R-HSA-9678110|reactome:R-HSA-9679191|reactome:R-HSA-9694614|rcsb pdb:7KNI|dip:DIP-44689N|refseq:NP_068576.1	-	curated-complex:Cell adhesion, bi-directional signaling receptor which functions as a link between the extra-cellular matrix and the cytoskeleton. Receptor for fibronectin and fibrinogen which its binds via the sequence R-G-D in the ligand.|complex-properties:The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. The ligand-binding site forms in a region at the intersection of the integrin alpha-chain beta-propeller and the betaI domain, with the alpha chain being central in determining ligand specificity.|ligand:"Fibronectin (P02751)"|complex-assembly:Heterodimer	comment:mint|function:Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses	figure legend:1B|comment:Clear inhibition of ACE2/a5b1 binding by ATN-161 was apparent and dose-dependent.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/06/29	2020/10/28	-	rogid:ZxuR6gzxz4Ns+hYH5uksGdn8S7o9606	-	false	-	fc-igg tag:c-c|sufficient binding region:1..18-740	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chembl target:CHEMBL2095226	uniprotkb:P02751	intact:EBI-2550721|reactome:R-HSA-202730|matrixdb:MULT_15_human|wwpdb:3vi3|signor:SIGNOR-C163	intact:EBI-1220319|uniprotkb:Q7Z391|uniprotkb:O95609|uniprotkb:O95610|uniprotkb:Q14312|uniprotkb:Q14325|uniprotkb:Q14326|uniprotkb:Q17RV7|uniprotkb:Q585T2|uniprotkb:Q59EH1|uniprotkb:Q60FE4|uniprotkb:Q68DP8|uniprotkb:Q68DP9|uniprotkb:Q68DT4|uniprotkb:Q6LDP6|uniprotkb:Q6MZU5|uniprotkb:Q6N025|uniprotkb:Q6N0A6|uniprotkb:Q86T27|uniprotkb:Q8IVI8|uniprotkb:Q96KP7|uniprotkb:Q96KP8|uniprotkb:Q96KP9|uniprotkb:Q9H1B8|uniprotkb:Q9HAP3|uniprotkb:Q9UMK2|uniprotkb:Q6MZS0|uniprotkb:B7ZLF0|uniprotkb:E9PE77|uniprotkb:E9PG29|uniprotkb:Q564H7|uniprotkb:Q53S27|ensembl:ENSP00000346839	psi-mi:intg_a5_b1_human(display_short)|psi-mi:CHEMBL2095226(display_long)|intact:alpha-5/beta-1 integrin complex(complex synonym)|intact:alpha5-beta1 integrin complex(complex synonym)|intact:"ITGA5:ITGB1"(complex systematic name)|intact:Integrin alpha5-beta1 complex(complex recommended name)	psi-mi:finc_human(display_long)|uniprotkb:FN1(gene name)|psi-mi:FN1(display_short)|uniprotkb:FN(gene name synonym)|uniprotkb:Cold-insoluble globulin(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Beddingfield et al. (2020)	pubmed:33102950|imex:IM-28488	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26429818|imex:IM-28488-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	pubmed:19693543(see-also)|pubmed:12297042(see-also)|go:"GO:0034674"(integrin alpha5-beta1 complex)|complex portal:CPX-1794(complex-primary)|evidence ontology:"ECO:0000353"|intact:EBI-26987514(exp-evidence)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0035313"(wound healing, spreading of epidermal cells)	refseq:NP_002017.1|refseq:NP_473375.2|refseq:NP_997639.1|refseq:NP_997641.1|refseq:NP_997643.1|refseq:NP_997647.1|refseq:NP_001293058.1|refseq:NP_001293059.1|refseq:NP_001293060.1|refseq:NP_001293061.1|refseq:XP_005246463.1|dip:DIP-29547N|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019899"(enzyme binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0033622"(integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|ensembl:ENSG00000115414(gene)|ensembl:ENST00000354785(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006953"(acute-phase response)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|interpro:IPR000083(Fibronectin, type I)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036116|interpro:IPR036943|mint:P02751|rcsb pdb:1E88|rcsb pdb:1E8B|rcsb pdb:1FBR|rcsb pdb:1FNA|rcsb pdb:1FNF|rcsb pdb:1FNH|rcsb pdb:1J8K|rcsb pdb:1O9A|rcsb pdb:1OWW|rcsb pdb:1Q38|rcsb pdb:1QGB|rcsb pdb:1QO6|rcsb pdb:1TTF|rcsb pdb:1TTG|rcsb pdb:2CG6|rcsb pdb:2CG7|rcsb pdb:2CK2|rcsb pdb:2CKU|rcsb pdb:2EC3|rcsb pdb:2FN2|rcsb pdb:2FNB|rcsb pdb:2GEE|rcsb pdb:2H41|rcsb pdb:2H45|rcsb pdb:2HA1|rcsb pdb:2MNU|rcsb pdb:2N1K|rcsb pdb:2OCF|rcsb pdb:2RKY|rcsb pdb:2RKZ|rcsb pdb:2RL0|rcsb pdb:3CAL|rcsb pdb:3EJH|rcsb pdb:3GXE|rcsb pdb:3M7P|rcsb pdb:3MQL|rcsb pdb:3R8Q|rcsb pdb:3T1W|rcsb pdb:3ZRZ|rcsb pdb:4GH7|rcsb pdb:4JE4|rcsb pdb:4JEG|rcsb pdb:4LXO|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|rcsb pdb:4PZ5|rcsb pdb:5DC0|rcsb pdb:5DC4|rcsb pdb:5DC9|rcsb pdb:5DFT|rcsb pdb:5J6Z|rcsb pdb:5J7C|rcsb pdb:5M0A|rcsb pdb:5N47|rcsb pdb:5N48|rcsb pdb:6HNF|rcsb pdb:6MFA|rcsb pdb:6MSV|rcsb pdb:6NAJ|rcsb pdb:6XAX|rcsb pdb:6XAY|rcsb pdb:7NWL|reactome:R-HSA-114608|reactome:R-HSA-1474228|reactome:R-HSA-1474244|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381426|reactome:R-HSA-5674135|reactome:R-HSA-6785807|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8874081|reactome:R-HSA-8957275|reactome:R-HSA-9649948|reactome:R-HSA-9656223	-	curated-complex:Cell adhesion, bi-directional signaling receptor which functions as a link between the extra-cellular matrix and the cytoskeleton. Receptor for fibronectin and fibrinogen which its binds via the sequence R-G-D in the ligand.|complex-properties:The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. The ligand-binding site forms in a region at the intersection of the integrin alpha-chain beta-propeller and the betaI domain, with the alpha chain being central in determining ligand specificity.|ligand:"Fibronectin (P02751)"|complex-assembly:Heterodimer	-	figure legend:1B|comment:Clear inhibition of ACE2/a5b1 binding by ATN-161 was apparent and dose-dependent.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/06/29	2020/10/28	-	rogid:4arZu49X8b+dthqaX4DIh59V8h09606	-	false	-	N-acetyl-L-proline:1498-1498|sufficient binding region:1498-1502|mutation:1501-1501	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9BYF1	uniprotkb:P0DTC2	intact:EBI-7730807|ensembl:ENSP00000252519|ensembl:ENSP00000389326|ensembl:ENSP00000504103|ensembl:ENSP00000505992|intact:EBI-25767352|uniprotkb:Q9UFZ6|uniprotkb:Q9NRA7|intact:MINT-4538816|uniprotkb:C7ECU1|uniprotkb:Q6UWP0|uniprotkb:Q86WT0|uniprotkb:A0A7D6JAD5|intact:EBI-15814450	intact:EBI-25474821	psi-mi:ace2_human(display_long)|uniprotkb:ACE2(gene name)|psi-mi:ACE2(display_short)|uniprotkb:UNQ868/PRO1885(orf name)|uniprotkb:Angiotensin-converting enzyme homolog(gene name synonym)|uniprotkb:Metalloprotease MPROT15(gene name synonym)|uniprotkb:Angiotensin-converting enzyme-related carboxypeptidase(gene name synonym)	psi-mi:spike_sars2(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Beddingfield et al. (2020)	pubmed:33102950|imex:IM-28488	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26429900|imex:IM-28488-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000252519(transcript)|ensembl:ENST00000427411(transcript)|ensembl:ENST00000678073(transcript)|ensembl:ENST00000680121(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0003051"(angiotensin-mediated drinking behavior)|go:"GO:0003081"(regulation of systemic arterial blood pressure by renin-angiotensin)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004180"(carboxypeptidase activity)|go:"GO:0004181"(metallocarboxypeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006508"(proteolysis)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008241"(peptidyl-dipeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0015827"(tryptophan transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|ensembl:ENSG00000130234(gene)|go:"GO:0051957"(positive regulation of amino acid transport)|go:"GO:0060452"(positive regulation of cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1905737"(positive regulation of L-proline import across plasma membrane)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR001548(Peptidase M2, peptidyl-dipeptidase A)|interpro:IPR031588|mint:Q9BYF1|rcsb pdb:1R42|rcsb pdb:1R4L|rcsb pdb:1XJP|rcsb pdb:2AJF|rcsb pdb:3D0G|rcsb pdb:3D0H|rcsb pdb:3D0I|rcsb pdb:3KBH|rcsb pdb:3SCI|rcsb pdb:3SCJ|rcsb pdb:3SCK|rcsb pdb:3SCL|rcsb pdb:6ACG|rcsb pdb:6ACJ|rcsb pdb:6ACK|rcsb pdb:6CS2|rcsb pdb:6LZG|rcsb pdb:6M0J|rcsb pdb:6M17|rcsb pdb:6M18|go:"GO:0050727"(regulation of inflammatory response)|rcsb pdb:6M1D|rcsb pdb:6VW1|rcsb pdb:7A91|rcsb pdb:7A92|rcsb pdb:7A94|rcsb pdb:7A95|rcsb pdb:7A96|rcsb pdb:7A97|rcsb pdb:7A98|rcsb pdb:7BH9|rcsb pdb:7CT5|rcsb pdb:7DDO|rcsb pdb:7DDP|rcsb pdb:7DF4|rcsb pdb:7DMU|rcsb pdb:7DWX|rcsb pdb:7DX4|rcsb pdb:7DX5|rcsb pdb:7DX6|rcsb pdb:7DX7|rcsb pdb:7DX8|rcsb pdb:7DX9|rcsb pdb:7JVO|rcsb pdb:7KJ2|rcsb pdb:7KJ3|rcsb pdb:7KJ4|rcsb pdb:7KMB|rcsb pdb:7KMS|rcsb pdb:7KMZ|rcsb pdb:7KNB|rcsb pdb:7KNE|rcsb pdb:7KNH|rcsb pdb:7L0N|rcsb pdb:7L7F|rcsb pdb:7LO4|rcsb pdb:7MJM|rcsb pdb:7MJN|rcsb pdb:7NXC|reactome:R-HSA-2022377|reactome:R-HSA-9678110|reactome:R-HSA-9679191|reactome:R-HSA-9694614|rcsb pdb:7KNI|dip:DIP-44689N|refseq:NP_068576.1	interpro:IPR043002|interpro:IPR044873|rcsb pdb:7MJI|rcsb pdb:7MJJ|rcsb pdb:7MJK|rcsb pdb:7MJL|rcsb pdb:7MJM|rcsb pdb:7MJN|rcsb pdb:7MKB|rcsb pdb:7MKL|rcsb pdb:7MKM|rcsb pdb:7MMO|rcsb pdb:7MY2|rcsb pdb:7MY3|rcsb pdb:7N0G|rcsb pdb:7N0H|rcsb pdb:7NEG|rcsb pdb:7NKT|rcsb pdb:7NT9|rcsb pdb:7NTA|rcsb pdb:7NTC|rcsb pdb:7NX6|rcsb pdb:7NX7|rcsb pdb:7NX8|rcsb pdb:7NX9|rcsb pdb:7NXA|rcsb pdb:7NXB|rcsb pdb:7NXC|rcsb pdb:7AKD|rcsb pdb:7B14|rcsb pdb:7B18|rcsb pdb:7B62|rcsb pdb:7C53|rcsb pdb:7CHO|rcsb pdb:7CHP|rcsb pdb:7CHS|rcsb pdb:7CN4|rcsb pdb:7CWT|rcsb pdb:7CYH|rcsb pdb:7CYP|rcsb pdb:7CZP|rcsb pdb:7CZQ|rcsb pdb:7CZR|rcsb pdb:7CZS|rcsb pdb:7CZT|rcsb pdb:7CZU|rcsb pdb:7CZV|rcsb pdb:7CZW|rcsb pdb:7CZX|rcsb pdb:7CZY|rcsb pdb:7CZZ|rcsb pdb:7D00|rcsb pdb:7D03|rcsb pdb:7D0B|rcsb pdb:7D0C|rcsb pdb:7D0D|rcsb pdb:7D4G|rcsb pdb:7DEO|rcsb pdb:7DET|rcsb pdb:7DEU|interpro:IPR044874|rcsb pdb:7DJZ|rcsb pdb:7DK0|rcsb pdb:7DWX|rcsb pdb:7DWY|rcsb pdb:7DWZ|rcsb pdb:7DX0|rcsb pdb:7DX1|rcsb pdb:7DX2|rcsb pdb:7DX3|rcsb pdb:7DX4|rcsb pdb:7DX5|rcsb pdb:7DX6|rcsb pdb:7DX7|rcsb pdb:7DX8|rcsb pdb:7DX9|rcsb pdb:7DZW|rcsb pdb:7DZX|rcsb pdb:7DZY|rcsb pdb:7E23|rcsb pdb:7E3J|rcsb pdb:7E5Y|rcsb pdb:7E7B|rcsb pdb:7E7D|rcsb pdb:7E7X|rcsb pdb:7E7Y|rcsb pdb:7E86|rcsb pdb:7E88|rcsb pdb:7E8C|rcsb pdb:7E8F|rcsb pdb:7E8M|rcsb pdb:7EAM|rcsb pdb:7EAN|rcsb pdb:7EAZ|rcsb pdb:7EB0|rcsb pdb:7EB3|rcsb pdb:7EB4|rcsb pdb:7EB5|rcsb pdb:7EJ4|rcsb pdb:7EJ5|rcsb pdb:7EK6|rcsb pdb:7KFV|rcsb pdb:7KFW|rcsb pdb:7KFX|rcsb pdb:7KFY|rcsb pdb:7KQB|rcsb pdb:7KQE|rcsb pdb:7KRQ|rcsb pdb:7KRR|rcsb pdb:7KRS|rcsb pdb:7L2D|rcsb pdb:7L2E|rcsb pdb:7L2F|rcsb pdb:7L4Z|rcsb pdb:7L56|rcsb pdb:7L57|rcsb pdb:7L58|rcsb pdb:7LAA|rcsb pdb:7LAB|rcsb pdb:7LC8|rcsb pdb:7LDJ|rcsb pdb:7LJR|rcsb pdb:7LM8|rcsb pdb:7LO4|rcsb pdb:7LQV|rcsb pdb:7LQW|rcsb pdb:7LS9|rcsb pdb:7LSS|rcsb pdb:7LWI|rcsb pdb:7LWJ|rcsb pdb:7LWK|rcsb pdb:7LWL|rcsb pdb:7LWM|rcsb pdb:7LWN|rcsb pdb:7LWO|rcsb pdb:7LWP|rcsb pdb:7LWQ|rcsb pdb:7LWS|rcsb pdb:7LWT|rcsb pdb:7LWU|rcsb pdb:7LWV|rcsb pdb:7LWW|rcsb pdb:7LX5|rcsb pdb:7LXW|rcsb pdb:7LXX|rcsb pdb:7LXY|rcsb pdb:7LXZ|rcsb pdb:7LY0|rcsb pdb:7LY2|rcsb pdb:7LY3|rcsb pdb:7LYK|rcsb pdb:7LYL|rcsb pdb:7LYM|rcsb pdb:7LYN|rcsb pdb:7LYO|rcsb pdb:7LYP|rcsb pdb:7LYQ|rcsb pdb:7M0J|rcsb pdb:7M6D|rcsb pdb:7M6E|rcsb pdb:7M6F|rcsb pdb:7M6G|rcsb pdb:7M6H|rcsb pdb:7M6I|rcsb pdb:7M71|rcsb pdb:7M7B|rcsb pdb:7M7W|rcsb pdb:7M8J|rcsb pdb:7M8K|rcsb pdb:7M8S|rcsb pdb:7M8T|rcsb pdb:7M8U|rcsb pdb:7MF1|rcsb pdb:7MFU|rcsb pdb:7M3I|rcsb pdb:7M53|rcsb pdb:7MJG|rcsb pdb:7MJH|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|interpro:IPR043473|rcsb pdb:6LZG|rcsb pdb:6VW1|rcsb pdb:6YLA|rcsb pdb:6YM0|rcsb pdb:6YOR|rcsb pdb:7BZ5|refseq:YP_009724390.1|rcsb pdb:7KMG|rcsb pdb:7KMH|rcsb pdb:7KMI|rcsb pdb:7KMK|rcsb pdb:7KML|rcsb pdb:7KN5|rcsb pdb:7KN6|rcsb pdb:7KN7|rcsb pdb:7KS9|rcsb pdb:7KSG|rcsb pdb:7KXJ|rcsb pdb:7KXK|rcsb pdb:7KZB|rcsb pdb:7L0N|rcsb pdb:7L2C|rcsb pdb:7L3N|rcsb pdb:7L5B|rcsb pdb:7L7F|rcsb pdb:7L7K|rcsb pdb:7LCN|rcsb pdb:7LD1|rcsb pdb:7LOP|rcsb pdb:7ND3|rcsb pdb:7ND4|rcsb pdb:7ND5|rcsb pdb:7ND6|rcsb pdb:7ND7|rcsb pdb:7ND8|rcsb pdb:7ND9|rcsb pdb:7NDA|rcsb pdb:7NDB|rcsb pdb:7NDC|rcsb pdb:7NDD|rcsb pdb:7NEH|rcsb pdb:7B17|rcsb pdb:7BEH|rcsb pdb:7BEI|rcsb pdb:7BEJ|rcsb pdb:7BEK|rcsb pdb:7BEL|rcsb pdb:7BEM|rcsb pdb:7BEN|rcsb pdb:7BEO|rcsb pdb:7BEP|rcsb pdb:7C8J|rcsb pdb:7CAC|rcsb pdb:7CM4|rcsb pdb:7CWL|rcsb pdb:7D2Z|rcsb pdb:7D30|rcsb pdb:7DPM|rcsb pdb:7KGJ|rcsb pdb:7KGK|rcsb pdb:7KLG|rcsb pdb:7KLH|rcsb pdb:7KLW|interpro:IPR042578|rcsb pdb:7CAB|interpro:IPR044341|rcsb pdb:7CDI|interpro:IPR044366|rcsb pdb:7CDJ|rcsb pdb:6ZLR|rcsb pdb:7CJF|rcsb pdb:7CT5|rcsb pdb:7A25|rcsb pdb:7CWM|rcsb pdb:7CWN|rcsb pdb:7CWO|rcsb pdb:7CWS|rcsb pdb:7CWU|rcsb pdb:7DCC|rcsb pdb:7DCX|rcsb pdb:7DD2|rcsb pdb:7DD8|rcsb pdb:7DDD|rcsb pdb:7DDN|rcsb pdb:7DF3|rcsb pdb:7DF4|rcsb pdb:7DK3|rcsb pdb:7DK4|rcsb pdb:7DK5|rcsb pdb:7DK6|rcsb pdb:7DK7|rcsb pdb:7DMU|rcsb pdb:7JVB|rcsb pdb:7JWY|rcsb pdb:7K8M|rcsb pdb:7KJ2|rcsb pdb:7KJ3|rcsb pdb:7KJ4|rcsb pdb:7KJ5|rcsb pdb:7KKK|rcsb pdb:7KKL|rcsb pdb:7KL9|rcsb pdb:7KMB|rcsb pdb:7KMS|rcsb pdb:7KMZ|rcsb pdb:7KNB|rcsb pdb:7KNE|rcsb pdb:7KNH|rcsb pdb:7KNI|rcsb pdb:7L02|rcsb pdb:7L06|rcsb pdb:7L09|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR036326|rcsb pdb:6M17|rcsb pdb:6VSB|rcsb pdb:6VXX|rcsb pdb:6VYB|rcsb pdb:6LVN|rcsb pdb:6LXT|rcsb pdb:6M0J|rcsb pdb:6W41|interpro:IPR032500|interpro:IPR043607|rcsb pdb:6M1V|rcsb pdb:6WPS|rcsb pdb:6WPT|rcsb pdb:6X29|rcsb pdb:6X2A|rcsb pdb:6X2B|rcsb pdb:6X2C|rcsb pdb:6X6P|rcsb pdb:6XC2|rcsb pdb:6XC3|rcsb pdb:6XC4|rcsb pdb:6XC7|rcsb pdb:6XCM|rcsb pdb:6XCN|rcsb pdb:6XDG|rcsb pdb:6XE1|rcsb pdb:6XEY|rcsb pdb:6XKL|rcsb pdb:6XR8|rcsb pdb:6XRA|rcsb pdb:6XS6|rcsb pdb:6YZ5|rcsb pdb:6YZ7|rcsb pdb:6Z2M|rcsb pdb:6Z43|rcsb pdb:6ZCZ|rcsb pdb:6ZDH|rcsb pdb:6ZER|rcsb pdb:6ZFO|rcsb pdb:6ZGE|rcsb pdb:6ZGG|rcsb pdb:6ZGI|rcsb pdb:6ZOX|rcsb pdb:6ZOY|rcsb pdb:6ZOZ|rcsb pdb:6ZP0|rcsb pdb:6ZP1|rcsb pdb:6ZP2|rcsb pdb:7BWJ|rcsb pdb:7BYR|rcsb pdb:7C01|rcsb pdb:7C2L|rcsb pdb:7C8V|rcsb pdb:7C8W|rcsb pdb:7CAN|rcsb pdb:6X79|rcsb pdb:6XF5|rcsb pdb:6XF6|rcsb pdb:6XLU|rcsb pdb:6XM0|rcsb pdb:6XM3|rcsb pdb:6XM4|rcsb pdb:6XM5|rcsb pdb:6Z97|rcsb pdb:6ZBP|rcsb pdb:6ZDG|rcsb pdb:6ZH9|rcsb pdb:6ZHD|rcsb pdb:6ZOW|rcsb pdb:6ZP5|rcsb pdb:6ZP7|rcsb pdb:6ZWV|rcsb pdb:7C8D|rcsb pdb:7CAH|rcsb pdb:7CN9|rcsb pdb:7JJI|rcsb pdb:7JJJ|rcsb pdb:7JMO|rcsb pdb:7JMP|rcsb pdb:6XKP|rcsb pdb:6XKQ|rcsb pdb:6ZB4|rcsb pdb:6ZB5|rcsb pdb:6ZXN|rcsb pdb:7A29|rcsb pdb:7A4N|rcsb pdb:7A5R|rcsb pdb:7A5S|rcsb pdb:7A91|rcsb pdb:7A92|rcsb pdb:7A93|rcsb pdb:7A94|rcsb pdb:7A95|rcsb pdb:7A96|rcsb pdb:7A97|rcsb pdb:7A98|rcsb pdb:7AD1|rcsb pdb:7CAI|rcsb pdb:7CAK|rcsb pdb:7CH4|rcsb pdb:7CH5|rcsb pdb:7CHB|rcsb pdb:7CHC|rcsb pdb:7CHE|rcsb pdb:7CHF|rcsb pdb:7CHH|rcsb pdb:7JJC|rcsb pdb:7JMW|rcsb pdb:7JV2|rcsb pdb:7JV4|rcsb pdb:7JV6|rcsb pdb:7JVA|rcsb pdb:7JVC|rcsb pdb:7JW0|rcsb pdb:7JWB|rcsb pdb:7JX3|rcsb pdb:7JZL|rcsb pdb:7JZM|rcsb pdb:7JZN|rcsb pdb:7JZU|rcsb pdb:7K43|rcsb pdb:7K45|rcsb pdb:7K4N|rcsb pdb:7K8S|rcsb pdb:7K8T|rcsb pdb:7K8U|rcsb pdb:7K8V|rcsb pdb:7K8W|rcsb pdb:7K8X|rcsb pdb:7K8Y|rcsb pdb:7K8Z|rcsb pdb:7K90|rcsb pdb:7K9Z|rcsb pdb:7KDG|rcsb pdb:7KDH|rcsb pdb:7KDI|rcsb pdb:7KDJ|rcsb pdb:7KDK|rcsb pdb:7KDL|rcsb pdb:7KE4|rcsb pdb:7KE6|rcsb pdb:7KE7|rcsb pdb:7KE8|rcsb pdb:7KE9|rcsb pdb:7KEA|rcsb pdb:7KEB|rcsb pdb:7KEC|reactome:R-HSA-9694322|reactome:R-HSA-9694548|reactome:R-HSA-9694614|reactome:R-HSA-9694635	-	comment:mint|function:Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses	-	figure legend:1C|comment:Binding with Spike was seen with  ACE2 alone or in combination with a5b1.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/06/29	2020/12/07	rogid:ZxuR6gzxz4Ns+hYH5uksGdn8S7o9606	rogid:QpTiyy2B+5c9PtFcZD+nZTX7nng2697049	rigid:HsUltcKq/ARrTkmVPSSTEFwwdk8	false	fc-igg tag:c-c|sufficient binding region:1..18-740	sufficient binding region:319-541|his tag:c-c	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9BYF1	uniprotkb:P02751	intact:EBI-7730807|ensembl:ENSP00000252519|ensembl:ENSP00000389326|ensembl:ENSP00000504103|ensembl:ENSP00000505992|intact:EBI-25767352|uniprotkb:Q9UFZ6|uniprotkb:Q9NRA7|intact:MINT-4538816|uniprotkb:C7ECU1|uniprotkb:Q6UWP0|uniprotkb:Q86WT0|uniprotkb:A0A7D6JAD5|intact:EBI-15814450	intact:EBI-1220319|uniprotkb:Q7Z391|uniprotkb:O95609|uniprotkb:O95610|uniprotkb:Q14312|uniprotkb:Q14325|uniprotkb:Q14326|uniprotkb:Q17RV7|uniprotkb:Q585T2|uniprotkb:Q59EH1|uniprotkb:Q60FE4|uniprotkb:Q68DP8|uniprotkb:Q68DP9|uniprotkb:Q68DT4|uniprotkb:Q6LDP6|uniprotkb:Q6MZU5|uniprotkb:Q6N025|uniprotkb:Q6N0A6|uniprotkb:Q86T27|uniprotkb:Q8IVI8|uniprotkb:Q96KP7|uniprotkb:Q96KP8|uniprotkb:Q96KP9|uniprotkb:Q9H1B8|uniprotkb:Q9HAP3|uniprotkb:Q9UMK2|uniprotkb:Q6MZS0|uniprotkb:B7ZLF0|uniprotkb:E9PE77|uniprotkb:E9PG29|uniprotkb:Q564H7|uniprotkb:Q53S27|ensembl:ENSP00000346839	psi-mi:ace2_human(display_long)|uniprotkb:ACE2(gene name)|psi-mi:ACE2(display_short)|uniprotkb:UNQ868/PRO1885(orf name)|uniprotkb:Angiotensin-converting enzyme homolog(gene name synonym)|uniprotkb:Metalloprotease MPROT15(gene name synonym)|uniprotkb:Angiotensin-converting enzyme-related carboxypeptidase(gene name synonym)	psi-mi:finc_human(display_long)|uniprotkb:FN1(gene name)|psi-mi:FN1(display_short)|uniprotkb:FN(gene name synonym)|uniprotkb:Cold-insoluble globulin(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Beddingfield et al. (2020)	pubmed:33102950|imex:IM-28488	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26429973|imex:IM-28488-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000252519(transcript)|ensembl:ENST00000427411(transcript)|ensembl:ENST00000678073(transcript)|ensembl:ENST00000680121(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0003051"(angiotensin-mediated drinking behavior)|go:"GO:0003081"(regulation of systemic arterial blood pressure by renin-angiotensin)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004180"(carboxypeptidase activity)|go:"GO:0004181"(metallocarboxypeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006508"(proteolysis)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008241"(peptidyl-dipeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0015827"(tryptophan transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|ensembl:ENSG00000130234(gene)|go:"GO:0051957"(positive regulation of amino acid transport)|go:"GO:0060452"(positive regulation of cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1905737"(positive regulation of L-proline import across plasma membrane)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR001548(Peptidase M2, peptidyl-dipeptidase A)|interpro:IPR031588|mint:Q9BYF1|rcsb pdb:1R42|rcsb pdb:1R4L|rcsb pdb:1XJP|rcsb pdb:2AJF|rcsb pdb:3D0G|rcsb pdb:3D0H|rcsb pdb:3D0I|rcsb pdb:3KBH|rcsb pdb:3SCI|rcsb pdb:3SCJ|rcsb pdb:3SCK|rcsb pdb:3SCL|rcsb pdb:6ACG|rcsb pdb:6ACJ|rcsb pdb:6ACK|rcsb pdb:6CS2|rcsb pdb:6LZG|rcsb pdb:6M0J|rcsb pdb:6M17|rcsb pdb:6M18|go:"GO:0050727"(regulation of inflammatory response)|rcsb pdb:6M1D|rcsb pdb:6VW1|rcsb pdb:7A91|rcsb pdb:7A92|rcsb pdb:7A94|rcsb pdb:7A95|rcsb pdb:7A96|rcsb pdb:7A97|rcsb pdb:7A98|rcsb pdb:7BH9|rcsb pdb:7CT5|rcsb pdb:7DDO|rcsb pdb:7DDP|rcsb pdb:7DF4|rcsb pdb:7DMU|rcsb pdb:7DWX|rcsb pdb:7DX4|rcsb pdb:7DX5|rcsb pdb:7DX6|rcsb pdb:7DX7|rcsb pdb:7DX8|rcsb pdb:7DX9|rcsb pdb:7JVO|rcsb pdb:7KJ2|rcsb pdb:7KJ3|rcsb pdb:7KJ4|rcsb pdb:7KMB|rcsb pdb:7KMS|rcsb pdb:7KMZ|rcsb pdb:7KNB|rcsb pdb:7KNE|rcsb pdb:7KNH|rcsb pdb:7L0N|rcsb pdb:7L7F|rcsb pdb:7LO4|rcsb pdb:7MJM|rcsb pdb:7MJN|rcsb pdb:7NXC|reactome:R-HSA-2022377|reactome:R-HSA-9678110|reactome:R-HSA-9679191|reactome:R-HSA-9694614|rcsb pdb:7KNI|dip:DIP-44689N|refseq:NP_068576.1	refseq:NP_002017.1|refseq:NP_473375.2|refseq:NP_997639.1|refseq:NP_997641.1|refseq:NP_997643.1|refseq:NP_997647.1|refseq:NP_001293058.1|refseq:NP_001293059.1|refseq:NP_001293060.1|refseq:NP_001293061.1|refseq:XP_005246463.1|dip:DIP-29547N|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019899"(enzyme binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0033622"(integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|ensembl:ENSG00000115414(gene)|ensembl:ENST00000354785(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006953"(acute-phase response)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|interpro:IPR000083(Fibronectin, type I)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036116|interpro:IPR036943|mint:P02751|rcsb pdb:1E88|rcsb pdb:1E8B|rcsb pdb:1FBR|rcsb pdb:1FNA|rcsb pdb:1FNF|rcsb pdb:1FNH|rcsb pdb:1J8K|rcsb pdb:1O9A|rcsb pdb:1OWW|rcsb pdb:1Q38|rcsb pdb:1QGB|rcsb pdb:1QO6|rcsb pdb:1TTF|rcsb pdb:1TTG|rcsb pdb:2CG6|rcsb pdb:2CG7|rcsb pdb:2CK2|rcsb pdb:2CKU|rcsb pdb:2EC3|rcsb pdb:2FN2|rcsb pdb:2FNB|rcsb pdb:2GEE|rcsb pdb:2H41|rcsb pdb:2H45|rcsb pdb:2HA1|rcsb pdb:2MNU|rcsb pdb:2N1K|rcsb pdb:2OCF|rcsb pdb:2RKY|rcsb pdb:2RKZ|rcsb pdb:2RL0|rcsb pdb:3CAL|rcsb pdb:3EJH|rcsb pdb:3GXE|rcsb pdb:3M7P|rcsb pdb:3MQL|rcsb pdb:3R8Q|rcsb pdb:3T1W|rcsb pdb:3ZRZ|rcsb pdb:4GH7|rcsb pdb:4JE4|rcsb pdb:4JEG|rcsb pdb:4LXO|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|rcsb pdb:4PZ5|rcsb pdb:5DC0|rcsb pdb:5DC4|rcsb pdb:5DC9|rcsb pdb:5DFT|rcsb pdb:5J6Z|rcsb pdb:5J7C|rcsb pdb:5M0A|rcsb pdb:5N47|rcsb pdb:5N48|rcsb pdb:6HNF|rcsb pdb:6MFA|rcsb pdb:6MSV|rcsb pdb:6NAJ|rcsb pdb:6XAX|rcsb pdb:6XAY|rcsb pdb:7NWL|reactome:R-HSA-114608|reactome:R-HSA-1474228|reactome:R-HSA-1474244|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381426|reactome:R-HSA-5674135|reactome:R-HSA-6785807|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8874081|reactome:R-HSA-8957275|reactome:R-HSA-9649948|reactome:R-HSA-9656223	-	comment:mint|function:Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses	-	figure legend:1C|comment:ATN-161 reduced binding  of  spike protein to hACE2, either alone or in combination with a5b1, the latter of which   supported greater spike binding than to hACE2 alone.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/06/29	2020/12/07	rogid:ZxuR6gzxz4Ns+hYH5uksGdn8S7o9606	rogid:4arZu49X8b+dthqaX4DIh59V8h09606	rigid:ifvi7ujE/umoOOd5Y9t9R/Xwrq8	false	fc-igg tag:c-c|sufficient binding region:1..18-740	N-acetyl-L-proline:1498-1498|sufficient binding region:1498-1502|mutation:1501-1501	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9BYF1	uniprotkb:P0DTC2	intact:EBI-7730807|ensembl:ENSP00000252519|ensembl:ENSP00000389326|ensembl:ENSP00000504103|ensembl:ENSP00000505992|intact:EBI-25767352|uniprotkb:Q9UFZ6|uniprotkb:Q9NRA7|intact:MINT-4538816|uniprotkb:C7ECU1|uniprotkb:Q6UWP0|uniprotkb:Q86WT0|uniprotkb:A0A7D6JAD5|intact:EBI-15814450	intact:EBI-25474821	psi-mi:ace2_human(display_long)|uniprotkb:ACE2(gene name)|psi-mi:ACE2(display_short)|uniprotkb:UNQ868/PRO1885(orf name)|uniprotkb:Angiotensin-converting enzyme homolog(gene name synonym)|uniprotkb:Metalloprotease MPROT15(gene name synonym)|uniprotkb:Angiotensin-converting enzyme-related carboxypeptidase(gene name synonym)	psi-mi:spike_sars2(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Beddingfield et al. (2020)	pubmed:33102950|imex:IM-28488	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26429973|imex:IM-28488-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000252519(transcript)|ensembl:ENST00000427411(transcript)|ensembl:ENST00000678073(transcript)|ensembl:ENST00000680121(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0003051"(angiotensin-mediated drinking behavior)|go:"GO:0003081"(regulation of systemic arterial blood pressure by renin-angiotensin)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004180"(carboxypeptidase activity)|go:"GO:0004181"(metallocarboxypeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006508"(proteolysis)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008241"(peptidyl-dipeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0015827"(tryptophan transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|ensembl:ENSG00000130234(gene)|go:"GO:0051957"(positive regulation of amino acid transport)|go:"GO:0060452"(positive regulation of cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1905737"(positive regulation of L-proline import across plasma membrane)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR001548(Peptidase M2, peptidyl-dipeptidase A)|interpro:IPR031588|mint:Q9BYF1|rcsb pdb:1R42|rcsb pdb:1R4L|rcsb pdb:1XJP|rcsb pdb:2AJF|rcsb pdb:3D0G|rcsb pdb:3D0H|rcsb pdb:3D0I|rcsb pdb:3KBH|rcsb pdb:3SCI|rcsb pdb:3SCJ|rcsb pdb:3SCK|rcsb pdb:3SCL|rcsb pdb:6ACG|rcsb pdb:6ACJ|rcsb pdb:6ACK|rcsb pdb:6CS2|rcsb pdb:6LZG|rcsb pdb:6M0J|rcsb pdb:6M17|rcsb pdb:6M18|go:"GO:0050727"(regulation of inflammatory response)|rcsb pdb:6M1D|rcsb pdb:6VW1|rcsb pdb:7A91|rcsb pdb:7A92|rcsb pdb:7A94|rcsb pdb:7A95|rcsb pdb:7A96|rcsb pdb:7A97|rcsb pdb:7A98|rcsb pdb:7BH9|rcsb pdb:7CT5|rcsb pdb:7DDO|rcsb pdb:7DDP|rcsb pdb:7DF4|rcsb pdb:7DMU|rcsb pdb:7DWX|rcsb pdb:7DX4|rcsb pdb:7DX5|rcsb pdb:7DX6|rcsb pdb:7DX7|rcsb pdb:7DX8|rcsb pdb:7DX9|rcsb pdb:7JVO|rcsb pdb:7KJ2|rcsb pdb:7KJ3|rcsb pdb:7KJ4|rcsb pdb:7KMB|rcsb pdb:7KMS|rcsb pdb:7KMZ|rcsb pdb:7KNB|rcsb pdb:7KNE|rcsb pdb:7KNH|rcsb pdb:7L0N|rcsb pdb:7L7F|rcsb pdb:7LO4|rcsb pdb:7MJM|rcsb pdb:7MJN|rcsb pdb:7NXC|reactome:R-HSA-2022377|reactome:R-HSA-9678110|reactome:R-HSA-9679191|reactome:R-HSA-9694614|rcsb pdb:7KNI|dip:DIP-44689N|refseq:NP_068576.1	interpro:IPR043002|interpro:IPR044873|rcsb pdb:7MJI|rcsb pdb:7MJJ|rcsb pdb:7MJK|rcsb pdb:7MJL|rcsb pdb:7MJM|rcsb pdb:7MJN|rcsb pdb:7MKB|rcsb pdb:7MKL|rcsb pdb:7MKM|rcsb pdb:7MMO|rcsb pdb:7MY2|rcsb pdb:7MY3|rcsb pdb:7N0G|rcsb pdb:7N0H|rcsb pdb:7NEG|rcsb pdb:7NKT|rcsb pdb:7NT9|rcsb pdb:7NTA|rcsb pdb:7NTC|rcsb pdb:7NX6|rcsb pdb:7NX7|rcsb pdb:7NX8|rcsb pdb:7NX9|rcsb pdb:7NXA|rcsb pdb:7NXB|rcsb pdb:7NXC|rcsb pdb:7AKD|rcsb pdb:7B14|rcsb pdb:7B18|rcsb pdb:7B62|rcsb pdb:7C53|rcsb pdb:7CHO|rcsb pdb:7CHP|rcsb pdb:7CHS|rcsb pdb:7CN4|rcsb pdb:7CWT|rcsb pdb:7CYH|rcsb pdb:7CYP|rcsb pdb:7CZP|rcsb pdb:7CZQ|rcsb pdb:7CZR|rcsb pdb:7CZS|rcsb pdb:7CZT|rcsb pdb:7CZU|rcsb pdb:7CZV|rcsb pdb:7CZW|rcsb pdb:7CZX|rcsb pdb:7CZY|rcsb pdb:7CZZ|rcsb pdb:7D00|rcsb pdb:7D03|rcsb pdb:7D0B|rcsb pdb:7D0C|rcsb pdb:7D0D|rcsb pdb:7D4G|rcsb pdb:7DEO|rcsb pdb:7DET|rcsb pdb:7DEU|interpro:IPR044874|rcsb pdb:7DJZ|rcsb pdb:7DK0|rcsb pdb:7DWX|rcsb pdb:7DWY|rcsb pdb:7DWZ|rcsb pdb:7DX0|rcsb pdb:7DX1|rcsb pdb:7DX2|rcsb pdb:7DX3|rcsb pdb:7DX4|rcsb pdb:7DX5|rcsb pdb:7DX6|rcsb pdb:7DX7|rcsb pdb:7DX8|rcsb pdb:7DX9|rcsb pdb:7DZW|rcsb pdb:7DZX|rcsb pdb:7DZY|rcsb pdb:7E23|rcsb pdb:7E3J|rcsb pdb:7E5Y|rcsb pdb:7E7B|rcsb pdb:7E7D|rcsb pdb:7E7X|rcsb pdb:7E7Y|rcsb pdb:7E86|rcsb pdb:7E88|rcsb pdb:7E8C|rcsb pdb:7E8F|rcsb pdb:7E8M|rcsb pdb:7EAM|rcsb pdb:7EAN|rcsb pdb:7EAZ|rcsb pdb:7EB0|rcsb pdb:7EB3|rcsb pdb:7EB4|rcsb pdb:7EB5|rcsb pdb:7EJ4|rcsb pdb:7EJ5|rcsb pdb:7EK6|rcsb pdb:7KFV|rcsb pdb:7KFW|rcsb pdb:7KFX|rcsb pdb:7KFY|rcsb pdb:7KQB|rcsb pdb:7KQE|rcsb pdb:7KRQ|rcsb pdb:7KRR|rcsb pdb:7KRS|rcsb pdb:7L2D|rcsb pdb:7L2E|rcsb pdb:7L2F|rcsb pdb:7L4Z|rcsb pdb:7L56|rcsb pdb:7L57|rcsb pdb:7L58|rcsb pdb:7LAA|rcsb pdb:7LAB|rcsb pdb:7LC8|rcsb pdb:7LDJ|rcsb pdb:7LJR|rcsb pdb:7LM8|rcsb pdb:7LO4|rcsb pdb:7LQV|rcsb pdb:7LQW|rcsb pdb:7LS9|rcsb pdb:7LSS|rcsb pdb:7LWI|rcsb pdb:7LWJ|rcsb pdb:7LWK|rcsb pdb:7LWL|rcsb pdb:7LWM|rcsb pdb:7LWN|rcsb pdb:7LWO|rcsb pdb:7LWP|rcsb pdb:7LWQ|rcsb pdb:7LWS|rcsb pdb:7LWT|rcsb pdb:7LWU|rcsb pdb:7LWV|rcsb pdb:7LWW|rcsb pdb:7LX5|rcsb pdb:7LXW|rcsb pdb:7LXX|rcsb pdb:7LXY|rcsb pdb:7LXZ|rcsb pdb:7LY0|rcsb pdb:7LY2|rcsb pdb:7LY3|rcsb pdb:7LYK|rcsb pdb:7LYL|rcsb pdb:7LYM|rcsb pdb:7LYN|rcsb pdb:7LYO|rcsb pdb:7LYP|rcsb pdb:7LYQ|rcsb pdb:7M0J|rcsb pdb:7M6D|rcsb pdb:7M6E|rcsb pdb:7M6F|rcsb pdb:7M6G|rcsb pdb:7M6H|rcsb pdb:7M6I|rcsb pdb:7M71|rcsb pdb:7M7B|rcsb pdb:7M7W|rcsb pdb:7M8J|rcsb pdb:7M8K|rcsb pdb:7M8S|rcsb pdb:7M8T|rcsb pdb:7M8U|rcsb pdb:7MF1|rcsb pdb:7MFU|rcsb pdb:7M3I|rcsb pdb:7M53|rcsb pdb:7MJG|rcsb pdb:7MJH|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|interpro:IPR043473|rcsb pdb:6LZG|rcsb pdb:6VW1|rcsb pdb:6YLA|rcsb pdb:6YM0|rcsb pdb:6YOR|rcsb pdb:7BZ5|refseq:YP_009724390.1|rcsb pdb:7KMG|rcsb pdb:7KMH|rcsb pdb:7KMI|rcsb pdb:7KMK|rcsb pdb:7KML|rcsb pdb:7KN5|rcsb pdb:7KN6|rcsb pdb:7KN7|rcsb pdb:7KS9|rcsb pdb:7KSG|rcsb pdb:7KXJ|rcsb pdb:7KXK|rcsb pdb:7KZB|rcsb pdb:7L0N|rcsb pdb:7L2C|rcsb pdb:7L3N|rcsb pdb:7L5B|rcsb pdb:7L7F|rcsb pdb:7L7K|rcsb pdb:7LCN|rcsb pdb:7LD1|rcsb pdb:7LOP|rcsb pdb:7ND3|rcsb pdb:7ND4|rcsb pdb:7ND5|rcsb pdb:7ND6|rcsb pdb:7ND7|rcsb pdb:7ND8|rcsb pdb:7ND9|rcsb pdb:7NDA|rcsb pdb:7NDB|rcsb pdb:7NDC|rcsb pdb:7NDD|rcsb pdb:7NEH|rcsb pdb:7B17|rcsb pdb:7BEH|rcsb pdb:7BEI|rcsb pdb:7BEJ|rcsb pdb:7BEK|rcsb pdb:7BEL|rcsb pdb:7BEM|rcsb pdb:7BEN|rcsb pdb:7BEO|rcsb pdb:7BEP|rcsb pdb:7C8J|rcsb pdb:7CAC|rcsb pdb:7CM4|rcsb pdb:7CWL|rcsb pdb:7D2Z|rcsb pdb:7D30|rcsb pdb:7DPM|rcsb pdb:7KGJ|rcsb pdb:7KGK|rcsb pdb:7KLG|rcsb pdb:7KLH|rcsb pdb:7KLW|interpro:IPR042578|rcsb pdb:7CAB|interpro:IPR044341|rcsb pdb:7CDI|interpro:IPR044366|rcsb pdb:7CDJ|rcsb pdb:6ZLR|rcsb pdb:7CJF|rcsb pdb:7CT5|rcsb pdb:7A25|rcsb pdb:7CWM|rcsb pdb:7CWN|rcsb pdb:7CWO|rcsb pdb:7CWS|rcsb pdb:7CWU|rcsb pdb:7DCC|rcsb pdb:7DCX|rcsb pdb:7DD2|rcsb pdb:7DD8|rcsb pdb:7DDD|rcsb pdb:7DDN|rcsb pdb:7DF3|rcsb pdb:7DF4|rcsb pdb:7DK3|rcsb pdb:7DK4|rcsb pdb:7DK5|rcsb pdb:7DK6|rcsb pdb:7DK7|rcsb pdb:7DMU|rcsb pdb:7JVB|rcsb pdb:7JWY|rcsb pdb:7K8M|rcsb pdb:7KJ2|rcsb pdb:7KJ3|rcsb pdb:7KJ4|rcsb pdb:7KJ5|rcsb pdb:7KKK|rcsb pdb:7KKL|rcsb pdb:7KL9|rcsb pdb:7KMB|rcsb pdb:7KMS|rcsb pdb:7KMZ|rcsb pdb:7KNB|rcsb pdb:7KNE|rcsb pdb:7KNH|rcsb pdb:7KNI|rcsb pdb:7L02|rcsb pdb:7L06|rcsb pdb:7L09|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR036326|rcsb pdb:6M17|rcsb pdb:6VSB|rcsb pdb:6VXX|rcsb pdb:6VYB|rcsb pdb:6LVN|rcsb pdb:6LXT|rcsb pdb:6M0J|rcsb pdb:6W41|interpro:IPR032500|interpro:IPR043607|rcsb pdb:6M1V|rcsb pdb:6WPS|rcsb pdb:6WPT|rcsb pdb:6X29|rcsb pdb:6X2A|rcsb pdb:6X2B|rcsb pdb:6X2C|rcsb pdb:6X6P|rcsb pdb:6XC2|rcsb pdb:6XC3|rcsb pdb:6XC4|rcsb pdb:6XC7|rcsb pdb:6XCM|rcsb pdb:6XCN|rcsb pdb:6XDG|rcsb pdb:6XE1|rcsb pdb:6XEY|rcsb pdb:6XKL|rcsb pdb:6XR8|rcsb pdb:6XRA|rcsb pdb:6XS6|rcsb pdb:6YZ5|rcsb pdb:6YZ7|rcsb pdb:6Z2M|rcsb pdb:6Z43|rcsb pdb:6ZCZ|rcsb pdb:6ZDH|rcsb pdb:6ZER|rcsb pdb:6ZFO|rcsb pdb:6ZGE|rcsb pdb:6ZGG|rcsb pdb:6ZGI|rcsb pdb:6ZOX|rcsb pdb:6ZOY|rcsb pdb:6ZOZ|rcsb pdb:6ZP0|rcsb pdb:6ZP1|rcsb pdb:6ZP2|rcsb pdb:7BWJ|rcsb pdb:7BYR|rcsb pdb:7C01|rcsb pdb:7C2L|rcsb pdb:7C8V|rcsb pdb:7C8W|rcsb pdb:7CAN|rcsb pdb:6X79|rcsb pdb:6XF5|rcsb pdb:6XF6|rcsb pdb:6XLU|rcsb pdb:6XM0|rcsb pdb:6XM3|rcsb pdb:6XM4|rcsb pdb:6XM5|rcsb pdb:6Z97|rcsb pdb:6ZBP|rcsb pdb:6ZDG|rcsb pdb:6ZH9|rcsb pdb:6ZHD|rcsb pdb:6ZOW|rcsb pdb:6ZP5|rcsb pdb:6ZP7|rcsb pdb:6ZWV|rcsb pdb:7C8D|rcsb pdb:7CAH|rcsb pdb:7CN9|rcsb pdb:7JJI|rcsb pdb:7JJJ|rcsb pdb:7JMO|rcsb pdb:7JMP|rcsb pdb:6XKP|rcsb pdb:6XKQ|rcsb pdb:6ZB4|rcsb pdb:6ZB5|rcsb pdb:6ZXN|rcsb pdb:7A29|rcsb pdb:7A4N|rcsb pdb:7A5R|rcsb pdb:7A5S|rcsb pdb:7A91|rcsb pdb:7A92|rcsb pdb:7A93|rcsb pdb:7A94|rcsb pdb:7A95|rcsb pdb:7A96|rcsb pdb:7A97|rcsb pdb:7A98|rcsb pdb:7AD1|rcsb pdb:7CAI|rcsb pdb:7CAK|rcsb pdb:7CH4|rcsb pdb:7CH5|rcsb pdb:7CHB|rcsb pdb:7CHC|rcsb pdb:7CHE|rcsb pdb:7CHF|rcsb pdb:7CHH|rcsb pdb:7JJC|rcsb pdb:7JMW|rcsb pdb:7JV2|rcsb pdb:7JV4|rcsb pdb:7JV6|rcsb pdb:7JVA|rcsb pdb:7JVC|rcsb pdb:7JW0|rcsb pdb:7JWB|rcsb pdb:7JX3|rcsb pdb:7JZL|rcsb pdb:7JZM|rcsb pdb:7JZN|rcsb pdb:7JZU|rcsb pdb:7K43|rcsb pdb:7K45|rcsb pdb:7K4N|rcsb pdb:7K8S|rcsb pdb:7K8T|rcsb pdb:7K8U|rcsb pdb:7K8V|rcsb pdb:7K8W|rcsb pdb:7K8X|rcsb pdb:7K8Y|rcsb pdb:7K8Z|rcsb pdb:7K90|rcsb pdb:7K9Z|rcsb pdb:7KDG|rcsb pdb:7KDH|rcsb pdb:7KDI|rcsb pdb:7KDJ|rcsb pdb:7KDK|rcsb pdb:7KDL|rcsb pdb:7KE4|rcsb pdb:7KE6|rcsb pdb:7KE7|rcsb pdb:7KE8|rcsb pdb:7KE9|rcsb pdb:7KEA|rcsb pdb:7KEB|rcsb pdb:7KEC|reactome:R-HSA-9694322|reactome:R-HSA-9694548|reactome:R-HSA-9694614|reactome:R-HSA-9694635	-	comment:mint|function:Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses	-	figure legend:1C|comment:ATN-161 reduced binding  of  spike protein to hACE2, either alone or in combination with a5b1, the latter of which   supported greater spike binding than to hACE2 alone.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/06/29	2020/12/07	rogid:ZxuR6gzxz4Ns+hYH5uksGdn8S7o9606	rogid:QpTiyy2B+5c9PtFcZD+nZTX7nng2697049	rigid:ifvi7ujE/umoOOd5Y9t9R/Xwrq8	false	fc-igg tag:c-c|sufficient binding region:1..18-740	sufficient binding region:319-541|his tag:c-c	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9BYF1	uniprotkb:P0DTC2	intact:EBI-7730807|ensembl:ENSP00000252519|ensembl:ENSP00000389326|ensembl:ENSP00000504103|ensembl:ENSP00000505992|intact:EBI-25767352|uniprotkb:Q9UFZ6|uniprotkb:Q9NRA7|intact:MINT-4538816|uniprotkb:C7ECU1|uniprotkb:Q6UWP0|uniprotkb:Q86WT0|uniprotkb:A0A7D6JAD5|intact:EBI-15814450	intact:EBI-25474821	psi-mi:ace2_human(display_long)|uniprotkb:ACE2(gene name)|psi-mi:ACE2(display_short)|uniprotkb:UNQ868/PRO1885(orf name)|uniprotkb:Angiotensin-converting enzyme homolog(gene name synonym)|uniprotkb:Metalloprotease MPROT15(gene name synonym)|uniprotkb:Angiotensin-converting enzyme-related carboxypeptidase(gene name synonym)	psi-mi:spike_sars2(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Beddingfield et al. (2020)	pubmed:33102950|imex:IM-28488	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26430082|imex:IM-28488-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000252519(transcript)|ensembl:ENST00000427411(transcript)|ensembl:ENST00000678073(transcript)|ensembl:ENST00000680121(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0003051"(angiotensin-mediated drinking behavior)|go:"GO:0003081"(regulation of systemic arterial blood pressure by renin-angiotensin)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004180"(carboxypeptidase activity)|go:"GO:0004181"(metallocarboxypeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006508"(proteolysis)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008241"(peptidyl-dipeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0015827"(tryptophan transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|ensembl:ENSG00000130234(gene)|go:"GO:0051957"(positive regulation of amino acid transport)|go:"GO:0060452"(positive regulation of cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1905737"(positive regulation of L-proline import across plasma membrane)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR001548(Peptidase M2, peptidyl-dipeptidase A)|interpro:IPR031588|mint:Q9BYF1|rcsb pdb:1R42|rcsb pdb:1R4L|rcsb pdb:1XJP|rcsb pdb:2AJF|rcsb pdb:3D0G|rcsb pdb:3D0H|rcsb pdb:3D0I|rcsb pdb:3KBH|rcsb pdb:3SCI|rcsb pdb:3SCJ|rcsb pdb:3SCK|rcsb pdb:3SCL|rcsb pdb:6ACG|rcsb pdb:6ACJ|rcsb pdb:6ACK|rcsb pdb:6CS2|rcsb pdb:6LZG|rcsb pdb:6M0J|rcsb pdb:6M17|rcsb pdb:6M18|go:"GO:0050727"(regulation of inflammatory response)|rcsb pdb:6M1D|rcsb pdb:6VW1|rcsb pdb:7A91|rcsb pdb:7A92|rcsb pdb:7A94|rcsb pdb:7A95|rcsb pdb:7A96|rcsb pdb:7A97|rcsb pdb:7A98|rcsb pdb:7BH9|rcsb pdb:7CT5|rcsb pdb:7DDO|rcsb pdb:7DDP|rcsb pdb:7DF4|rcsb pdb:7DMU|rcsb pdb:7DWX|rcsb pdb:7DX4|rcsb pdb:7DX5|rcsb pdb:7DX6|rcsb pdb:7DX7|rcsb pdb:7DX8|rcsb pdb:7DX9|rcsb pdb:7JVO|rcsb pdb:7KJ2|rcsb pdb:7KJ3|rcsb pdb:7KJ4|rcsb pdb:7KMB|rcsb pdb:7KMS|rcsb pdb:7KMZ|rcsb pdb:7KNB|rcsb pdb:7KNE|rcsb pdb:7KNH|rcsb pdb:7L0N|rcsb pdb:7L7F|rcsb pdb:7LO4|rcsb pdb:7MJM|rcsb pdb:7MJN|rcsb pdb:7NXC|reactome:R-HSA-2022377|reactome:R-HSA-9678110|reactome:R-HSA-9679191|reactome:R-HSA-9694614|rcsb pdb:7KNI|dip:DIP-44689N|refseq:NP_068576.1	interpro:IPR043002|interpro:IPR044873|rcsb pdb:7MJI|rcsb pdb:7MJJ|rcsb pdb:7MJK|rcsb pdb:7MJL|rcsb pdb:7MJM|rcsb pdb:7MJN|rcsb pdb:7MKB|rcsb pdb:7MKL|rcsb pdb:7MKM|rcsb pdb:7MMO|rcsb pdb:7MY2|rcsb pdb:7MY3|rcsb pdb:7N0G|rcsb pdb:7N0H|rcsb pdb:7NEG|rcsb pdb:7NKT|rcsb pdb:7NT9|rcsb pdb:7NTA|rcsb pdb:7NTC|rcsb pdb:7NX6|rcsb pdb:7NX7|rcsb pdb:7NX8|rcsb pdb:7NX9|rcsb pdb:7NXA|rcsb pdb:7NXB|rcsb pdb:7NXC|rcsb pdb:7AKD|rcsb pdb:7B14|rcsb pdb:7B18|rcsb pdb:7B62|rcsb pdb:7C53|rcsb pdb:7CHO|rcsb pdb:7CHP|rcsb pdb:7CHS|rcsb pdb:7CN4|rcsb pdb:7CWT|rcsb pdb:7CYH|rcsb pdb:7CYP|rcsb pdb:7CZP|rcsb pdb:7CZQ|rcsb pdb:7CZR|rcsb pdb:7CZS|rcsb pdb:7CZT|rcsb pdb:7CZU|rcsb pdb:7CZV|rcsb pdb:7CZW|rcsb pdb:7CZX|rcsb pdb:7CZY|rcsb pdb:7CZZ|rcsb pdb:7D00|rcsb pdb:7D03|rcsb pdb:7D0B|rcsb pdb:7D0C|rcsb pdb:7D0D|rcsb pdb:7D4G|rcsb pdb:7DEO|rcsb pdb:7DET|rcsb pdb:7DEU|interpro:IPR044874|rcsb pdb:7DJZ|rcsb pdb:7DK0|rcsb pdb:7DWX|rcsb pdb:7DWY|rcsb pdb:7DWZ|rcsb pdb:7DX0|rcsb pdb:7DX1|rcsb pdb:7DX2|rcsb pdb:7DX3|rcsb pdb:7DX4|rcsb pdb:7DX5|rcsb pdb:7DX6|rcsb pdb:7DX7|rcsb pdb:7DX8|rcsb pdb:7DX9|rcsb pdb:7DZW|rcsb pdb:7DZX|rcsb pdb:7DZY|rcsb pdb:7E23|rcsb pdb:7E3J|rcsb pdb:7E5Y|rcsb pdb:7E7B|rcsb pdb:7E7D|rcsb pdb:7E7X|rcsb pdb:7E7Y|rcsb pdb:7E86|rcsb pdb:7E88|rcsb pdb:7E8C|rcsb pdb:7E8F|rcsb pdb:7E8M|rcsb pdb:7EAM|rcsb pdb:7EAN|rcsb pdb:7EAZ|rcsb pdb:7EB0|rcsb pdb:7EB3|rcsb pdb:7EB4|rcsb pdb:7EB5|rcsb pdb:7EJ4|rcsb pdb:7EJ5|rcsb pdb:7EK6|rcsb pdb:7KFV|rcsb pdb:7KFW|rcsb pdb:7KFX|rcsb pdb:7KFY|rcsb pdb:7KQB|rcsb pdb:7KQE|rcsb pdb:7KRQ|rcsb pdb:7KRR|rcsb pdb:7KRS|rcsb pdb:7L2D|rcsb pdb:7L2E|rcsb pdb:7L2F|rcsb pdb:7L4Z|rcsb pdb:7L56|rcsb pdb:7L57|rcsb pdb:7L58|rcsb pdb:7LAA|rcsb pdb:7LAB|rcsb pdb:7LC8|rcsb pdb:7LDJ|rcsb pdb:7LJR|rcsb pdb:7LM8|rcsb pdb:7LO4|rcsb pdb:7LQV|rcsb pdb:7LQW|rcsb pdb:7LS9|rcsb pdb:7LSS|rcsb pdb:7LWI|rcsb pdb:7LWJ|rcsb pdb:7LWK|rcsb pdb:7LWL|rcsb pdb:7LWM|rcsb pdb:7LWN|rcsb pdb:7LWO|rcsb pdb:7LWP|rcsb pdb:7LWQ|rcsb pdb:7LWS|rcsb pdb:7LWT|rcsb pdb:7LWU|rcsb pdb:7LWV|rcsb pdb:7LWW|rcsb pdb:7LX5|rcsb pdb:7LXW|rcsb pdb:7LXX|rcsb pdb:7LXY|rcsb pdb:7LXZ|rcsb pdb:7LY0|rcsb pdb:7LY2|rcsb pdb:7LY3|rcsb pdb:7LYK|rcsb pdb:7LYL|rcsb pdb:7LYM|rcsb pdb:7LYN|rcsb pdb:7LYO|rcsb pdb:7LYP|rcsb pdb:7LYQ|rcsb pdb:7M0J|rcsb pdb:7M6D|rcsb pdb:7M6E|rcsb pdb:7M6F|rcsb pdb:7M6G|rcsb pdb:7M6H|rcsb pdb:7M6I|rcsb pdb:7M71|rcsb pdb:7M7B|rcsb pdb:7M7W|rcsb pdb:7M8J|rcsb pdb:7M8K|rcsb pdb:7M8S|rcsb pdb:7M8T|rcsb pdb:7M8U|rcsb pdb:7MF1|rcsb pdb:7MFU|rcsb pdb:7M3I|rcsb pdb:7M53|rcsb pdb:7MJG|rcsb pdb:7MJH|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|interpro:IPR043473|rcsb pdb:6LZG|rcsb pdb:6VW1|rcsb pdb:6YLA|rcsb pdb:6YM0|rcsb pdb:6YOR|rcsb pdb:7BZ5|refseq:YP_009724390.1|rcsb pdb:7KMG|rcsb pdb:7KMH|rcsb pdb:7KMI|rcsb pdb:7KMK|rcsb pdb:7KML|rcsb pdb:7KN5|rcsb pdb:7KN6|rcsb pdb:7KN7|rcsb pdb:7KS9|rcsb pdb:7KSG|rcsb pdb:7KXJ|rcsb pdb:7KXK|rcsb pdb:7KZB|rcsb pdb:7L0N|rcsb pdb:7L2C|rcsb pdb:7L3N|rcsb pdb:7L5B|rcsb pdb:7L7F|rcsb pdb:7L7K|rcsb pdb:7LCN|rcsb pdb:7LD1|rcsb pdb:7LOP|rcsb pdb:7ND3|rcsb pdb:7ND4|rcsb pdb:7ND5|rcsb pdb:7ND6|rcsb pdb:7ND7|rcsb pdb:7ND8|rcsb pdb:7ND9|rcsb pdb:7NDA|rcsb pdb:7NDB|rcsb pdb:7NDC|rcsb pdb:7NDD|rcsb pdb:7NEH|rcsb pdb:7B17|rcsb pdb:7BEH|rcsb pdb:7BEI|rcsb pdb:7BEJ|rcsb pdb:7BEK|rcsb pdb:7BEL|rcsb pdb:7BEM|rcsb pdb:7BEN|rcsb pdb:7BEO|rcsb pdb:7BEP|rcsb pdb:7C8J|rcsb pdb:7CAC|rcsb pdb:7CM4|rcsb pdb:7CWL|rcsb pdb:7D2Z|rcsb pdb:7D30|rcsb pdb:7DPM|rcsb pdb:7KGJ|rcsb pdb:7KGK|rcsb pdb:7KLG|rcsb pdb:7KLH|rcsb pdb:7KLW|interpro:IPR042578|rcsb pdb:7CAB|interpro:IPR044341|rcsb pdb:7CDI|interpro:IPR044366|rcsb pdb:7CDJ|rcsb pdb:6ZLR|rcsb pdb:7CJF|rcsb pdb:7CT5|rcsb pdb:7A25|rcsb pdb:7CWM|rcsb pdb:7CWN|rcsb pdb:7CWO|rcsb pdb:7CWS|rcsb pdb:7CWU|rcsb pdb:7DCC|rcsb pdb:7DCX|rcsb pdb:7DD2|rcsb pdb:7DD8|rcsb pdb:7DDD|rcsb pdb:7DDN|rcsb pdb:7DF3|rcsb pdb:7DF4|rcsb pdb:7DK3|rcsb pdb:7DK4|rcsb pdb:7DK5|rcsb pdb:7DK6|rcsb pdb:7DK7|rcsb pdb:7DMU|rcsb pdb:7JVB|rcsb pdb:7JWY|rcsb pdb:7K8M|rcsb pdb:7KJ2|rcsb pdb:7KJ3|rcsb pdb:7KJ4|rcsb pdb:7KJ5|rcsb pdb:7KKK|rcsb pdb:7KKL|rcsb pdb:7KL9|rcsb pdb:7KMB|rcsb pdb:7KMS|rcsb pdb:7KMZ|rcsb pdb:7KNB|rcsb pdb:7KNE|rcsb pdb:7KNH|rcsb pdb:7KNI|rcsb pdb:7L02|rcsb pdb:7L06|rcsb pdb:7L09|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR036326|rcsb pdb:6M17|rcsb pdb:6VSB|rcsb pdb:6VXX|rcsb pdb:6VYB|rcsb pdb:6LVN|rcsb pdb:6LXT|rcsb pdb:6M0J|rcsb pdb:6W41|interpro:IPR032500|interpro:IPR043607|rcsb pdb:6M1V|rcsb pdb:6WPS|rcsb pdb:6WPT|rcsb pdb:6X29|rcsb pdb:6X2A|rcsb pdb:6X2B|rcsb pdb:6X2C|rcsb pdb:6X6P|rcsb pdb:6XC2|rcsb pdb:6XC3|rcsb pdb:6XC4|rcsb pdb:6XC7|rcsb pdb:6XCM|rcsb pdb:6XCN|rcsb pdb:6XDG|rcsb pdb:6XE1|rcsb pdb:6XEY|rcsb pdb:6XKL|rcsb pdb:6XR8|rcsb pdb:6XRA|rcsb pdb:6XS6|rcsb pdb:6YZ5|rcsb pdb:6YZ7|rcsb pdb:6Z2M|rcsb pdb:6Z43|rcsb pdb:6ZCZ|rcsb pdb:6ZDH|rcsb pdb:6ZER|rcsb pdb:6ZFO|rcsb pdb:6ZGE|rcsb pdb:6ZGG|rcsb pdb:6ZGI|rcsb pdb:6ZOX|rcsb pdb:6ZOY|rcsb pdb:6ZOZ|rcsb pdb:6ZP0|rcsb pdb:6ZP1|rcsb pdb:6ZP2|rcsb pdb:7BWJ|rcsb pdb:7BYR|rcsb pdb:7C01|rcsb pdb:7C2L|rcsb pdb:7C8V|rcsb pdb:7C8W|rcsb pdb:7CAN|rcsb pdb:6X79|rcsb pdb:6XF5|rcsb pdb:6XF6|rcsb pdb:6XLU|rcsb pdb:6XM0|rcsb pdb:6XM3|rcsb pdb:6XM4|rcsb pdb:6XM5|rcsb pdb:6Z97|rcsb pdb:6ZBP|rcsb pdb:6ZDG|rcsb pdb:6ZH9|rcsb pdb:6ZHD|rcsb pdb:6ZOW|rcsb pdb:6ZP5|rcsb pdb:6ZP7|rcsb pdb:6ZWV|rcsb pdb:7C8D|rcsb pdb:7CAH|rcsb pdb:7CN9|rcsb pdb:7JJI|rcsb pdb:7JJJ|rcsb pdb:7JMO|rcsb pdb:7JMP|rcsb pdb:6XKP|rcsb pdb:6XKQ|rcsb pdb:6ZB4|rcsb pdb:6ZB5|rcsb pdb:6ZXN|rcsb pdb:7A29|rcsb pdb:7A4N|rcsb pdb:7A5R|rcsb pdb:7A5S|rcsb pdb:7A91|rcsb pdb:7A92|rcsb pdb:7A93|rcsb pdb:7A94|rcsb pdb:7A95|rcsb pdb:7A96|rcsb pdb:7A97|rcsb pdb:7A98|rcsb pdb:7AD1|rcsb pdb:7CAI|rcsb pdb:7CAK|rcsb pdb:7CH4|rcsb pdb:7CH5|rcsb pdb:7CHB|rcsb pdb:7CHC|rcsb pdb:7CHE|rcsb pdb:7CHF|rcsb pdb:7CHH|rcsb pdb:7JJC|rcsb pdb:7JMW|rcsb pdb:7JV2|rcsb pdb:7JV4|rcsb pdb:7JV6|rcsb pdb:7JVA|rcsb pdb:7JVC|rcsb pdb:7JW0|rcsb pdb:7JWB|rcsb pdb:7JX3|rcsb pdb:7JZL|rcsb pdb:7JZM|rcsb pdb:7JZN|rcsb pdb:7JZU|rcsb pdb:7K43|rcsb pdb:7K45|rcsb pdb:7K4N|rcsb pdb:7K8S|rcsb pdb:7K8T|rcsb pdb:7K8U|rcsb pdb:7K8V|rcsb pdb:7K8W|rcsb pdb:7K8X|rcsb pdb:7K8Y|rcsb pdb:7K8Z|rcsb pdb:7K90|rcsb pdb:7K9Z|rcsb pdb:7KDG|rcsb pdb:7KDH|rcsb pdb:7KDI|rcsb pdb:7KDJ|rcsb pdb:7KDK|rcsb pdb:7KDL|rcsb pdb:7KE4|rcsb pdb:7KE6|rcsb pdb:7KE7|rcsb pdb:7KE8|rcsb pdb:7KE9|rcsb pdb:7KEA|rcsb pdb:7KEB|rcsb pdb:7KEC|reactome:R-HSA-9694322|reactome:R-HSA-9694548|reactome:R-HSA-9694614|reactome:R-HSA-9694635	-	comment:mint|function:Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses	-	figure legend:Supp. figure 1|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/06/29	2020/12/07	rogid:ZxuR6gzxz4Ns+hYH5uksGdn8S7o9606	rogid:QpTiyy2B+5c9PtFcZD+nZTX7nng2697049	rigid:HsUltcKq/ARrTkmVPSSTEFwwdk8	false	fc-igg tag:c-c|sufficient binding region:1..18-740	sufficient binding region:319-541|his tag:c-c	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P0DTC2	uniprotkb:Q9BYF1	intact:EBI-25474821	intact:EBI-7730807|ensembl:ENSP00000252519|ensembl:ENSP00000389326|ensembl:ENSP00000504103|ensembl:ENSP00000505992|intact:EBI-25767352|uniprotkb:Q9UFZ6|uniprotkb:Q9NRA7|intact:MINT-4538816|uniprotkb:C7ECU1|uniprotkb:Q6UWP0|uniprotkb:Q86WT0|uniprotkb:A0A7D6JAD5|intact:EBI-15814450	psi-mi:spike_sars2(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name)	psi-mi:ace2_human(display_long)|uniprotkb:ACE2(gene name)|psi-mi:ACE2(display_short)|uniprotkb:UNQ868/PRO1885(orf name)|uniprotkb:Angiotensin-converting enzyme homolog(gene name synonym)|uniprotkb:Metalloprotease MPROT15(gene name synonym)|uniprotkb:Angiotensin-converting enzyme-related carboxypeptidase(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Beddingfield et al. (2020)	pubmed:33102950|imex:IM-28488	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26430094|imex:IM-28488-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR043002|interpro:IPR044873|rcsb pdb:7MJI|rcsb pdb:7MJJ|rcsb pdb:7MJK|rcsb pdb:7MJL|rcsb pdb:7MJM|rcsb pdb:7MJN|rcsb pdb:7MKB|rcsb pdb:7MKL|rcsb pdb:7MKM|rcsb pdb:7MMO|rcsb pdb:7MY2|rcsb pdb:7MY3|rcsb pdb:7N0G|rcsb pdb:7N0H|rcsb pdb:7NEG|rcsb pdb:7NKT|rcsb pdb:7NT9|rcsb pdb:7NTA|rcsb pdb:7NTC|rcsb pdb:7NX6|rcsb pdb:7NX7|rcsb pdb:7NX8|rcsb pdb:7NX9|rcsb pdb:7NXA|rcsb pdb:7NXB|rcsb pdb:7NXC|rcsb pdb:7AKD|rcsb pdb:7B14|rcsb pdb:7B18|rcsb pdb:7B62|rcsb pdb:7C53|rcsb pdb:7CHO|rcsb pdb:7CHP|rcsb pdb:7CHS|rcsb pdb:7CN4|rcsb pdb:7CWT|rcsb pdb:7CYH|rcsb pdb:7CYP|rcsb pdb:7CZP|rcsb pdb:7CZQ|rcsb pdb:7CZR|rcsb pdb:7CZS|rcsb pdb:7CZT|rcsb pdb:7CZU|rcsb pdb:7CZV|rcsb pdb:7CZW|rcsb pdb:7CZX|rcsb pdb:7CZY|rcsb pdb:7CZZ|rcsb pdb:7D00|rcsb pdb:7D03|rcsb pdb:7D0B|rcsb pdb:7D0C|rcsb pdb:7D0D|rcsb pdb:7D4G|rcsb pdb:7DEO|rcsb pdb:7DET|rcsb pdb:7DEU|interpro:IPR044874|rcsb pdb:7DJZ|rcsb pdb:7DK0|rcsb pdb:7DWX|rcsb pdb:7DWY|rcsb pdb:7DWZ|rcsb pdb:7DX0|rcsb pdb:7DX1|rcsb pdb:7DX2|rcsb pdb:7DX3|rcsb pdb:7DX4|rcsb pdb:7DX5|rcsb pdb:7DX6|rcsb pdb:7DX7|rcsb pdb:7DX8|rcsb pdb:7DX9|rcsb pdb:7DZW|rcsb pdb:7DZX|rcsb pdb:7DZY|rcsb pdb:7E23|rcsb pdb:7E3J|rcsb pdb:7E5Y|rcsb pdb:7E7B|rcsb pdb:7E7D|rcsb pdb:7E7X|rcsb pdb:7E7Y|rcsb pdb:7E86|rcsb pdb:7E88|rcsb pdb:7E8C|rcsb pdb:7E8F|rcsb pdb:7E8M|rcsb pdb:7EAM|rcsb pdb:7EAN|rcsb pdb:7EAZ|rcsb pdb:7EB0|rcsb pdb:7EB3|rcsb pdb:7EB4|rcsb pdb:7EB5|rcsb pdb:7EJ4|rcsb pdb:7EJ5|rcsb pdb:7EK6|rcsb pdb:7KFV|rcsb pdb:7KFW|rcsb pdb:7KFX|rcsb pdb:7KFY|rcsb pdb:7KQB|rcsb pdb:7KQE|rcsb pdb:7KRQ|rcsb pdb:7KRR|rcsb pdb:7KRS|rcsb pdb:7L2D|rcsb pdb:7L2E|rcsb pdb:7L2F|rcsb pdb:7L4Z|rcsb pdb:7L56|rcsb pdb:7L57|rcsb pdb:7L58|rcsb pdb:7LAA|rcsb pdb:7LAB|rcsb pdb:7LC8|rcsb pdb:7LDJ|rcsb pdb:7LJR|rcsb pdb:7LM8|rcsb pdb:7LO4|rcsb pdb:7LQV|rcsb pdb:7LQW|rcsb pdb:7LS9|rcsb pdb:7LSS|rcsb pdb:7LWI|rcsb pdb:7LWJ|rcsb pdb:7LWK|rcsb pdb:7LWL|rcsb pdb:7LWM|rcsb pdb:7LWN|rcsb pdb:7LWO|rcsb pdb:7LWP|rcsb pdb:7LWQ|rcsb pdb:7LWS|rcsb pdb:7LWT|rcsb pdb:7LWU|rcsb pdb:7LWV|rcsb pdb:7LWW|rcsb pdb:7LX5|rcsb pdb:7LXW|rcsb pdb:7LXX|rcsb pdb:7LXY|rcsb pdb:7LXZ|rcsb pdb:7LY0|rcsb pdb:7LY2|rcsb pdb:7LY3|rcsb pdb:7LYK|rcsb pdb:7LYL|rcsb pdb:7LYM|rcsb pdb:7LYN|rcsb pdb:7LYO|rcsb pdb:7LYP|rcsb pdb:7LYQ|rcsb pdb:7M0J|rcsb pdb:7M6D|rcsb pdb:7M6E|rcsb pdb:7M6F|rcsb pdb:7M6G|rcsb pdb:7M6H|rcsb pdb:7M6I|rcsb pdb:7M71|rcsb pdb:7M7B|rcsb pdb:7M7W|rcsb pdb:7M8J|rcsb pdb:7M8K|rcsb pdb:7M8S|rcsb pdb:7M8T|rcsb pdb:7M8U|rcsb pdb:7MF1|rcsb pdb:7MFU|rcsb pdb:7M3I|rcsb pdb:7M53|rcsb pdb:7MJG|rcsb pdb:7MJH|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|interpro:IPR043473|rcsb pdb:6LZG|rcsb pdb:6VW1|rcsb pdb:6YLA|rcsb pdb:6YM0|rcsb pdb:6YOR|rcsb pdb:7BZ5|refseq:YP_009724390.1|rcsb pdb:7KMG|rcsb pdb:7KMH|rcsb pdb:7KMI|rcsb pdb:7KMK|rcsb pdb:7KML|rcsb pdb:7KN5|rcsb pdb:7KN6|rcsb pdb:7KN7|rcsb pdb:7KS9|rcsb pdb:7KSG|rcsb pdb:7KXJ|rcsb pdb:7KXK|rcsb pdb:7KZB|rcsb pdb:7L0N|rcsb pdb:7L2C|rcsb pdb:7L3N|rcsb pdb:7L5B|rcsb pdb:7L7F|rcsb pdb:7L7K|rcsb pdb:7LCN|rcsb pdb:7LD1|rcsb pdb:7LOP|rcsb pdb:7ND3|rcsb pdb:7ND4|rcsb pdb:7ND5|rcsb pdb:7ND6|rcsb pdb:7ND7|rcsb pdb:7ND8|rcsb pdb:7ND9|rcsb pdb:7NDA|rcsb pdb:7NDB|rcsb pdb:7NDC|rcsb pdb:7NDD|rcsb pdb:7NEH|rcsb pdb:7B17|rcsb pdb:7BEH|rcsb pdb:7BEI|rcsb pdb:7BEJ|rcsb pdb:7BEK|rcsb pdb:7BEL|rcsb pdb:7BEM|rcsb pdb:7BEN|rcsb pdb:7BEO|rcsb pdb:7BEP|rcsb pdb:7C8J|rcsb pdb:7CAC|rcsb pdb:7CM4|rcsb pdb:7CWL|rcsb pdb:7D2Z|rcsb pdb:7D30|rcsb pdb:7DPM|rcsb pdb:7KGJ|rcsb pdb:7KGK|rcsb pdb:7KLG|rcsb pdb:7KLH|rcsb pdb:7KLW|interpro:IPR042578|rcsb pdb:7CAB|interpro:IPR044341|rcsb pdb:7CDI|interpro:IPR044366|rcsb pdb:7CDJ|rcsb pdb:6ZLR|rcsb pdb:7CJF|rcsb pdb:7CT5|rcsb pdb:7A25|rcsb pdb:7CWM|rcsb pdb:7CWN|rcsb pdb:7CWO|rcsb pdb:7CWS|rcsb pdb:7CWU|rcsb pdb:7DCC|rcsb pdb:7DCX|rcsb pdb:7DD2|rcsb pdb:7DD8|rcsb pdb:7DDD|rcsb pdb:7DDN|rcsb pdb:7DF3|rcsb pdb:7DF4|rcsb pdb:7DK3|rcsb pdb:7DK4|rcsb pdb:7DK5|rcsb pdb:7DK6|rcsb pdb:7DK7|rcsb pdb:7DMU|rcsb pdb:7JVB|rcsb pdb:7JWY|rcsb pdb:7K8M|rcsb pdb:7KJ2|rcsb pdb:7KJ3|rcsb pdb:7KJ4|rcsb pdb:7KJ5|rcsb pdb:7KKK|rcsb pdb:7KKL|rcsb pdb:7KL9|rcsb pdb:7KMB|rcsb pdb:7KMS|rcsb pdb:7KMZ|rcsb pdb:7KNB|rcsb pdb:7KNE|rcsb pdb:7KNH|rcsb pdb:7KNI|rcsb pdb:7L02|rcsb pdb:7L06|rcsb pdb:7L09|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR036326|rcsb pdb:6M17|rcsb pdb:6VSB|rcsb pdb:6VXX|rcsb pdb:6VYB|rcsb pdb:6LVN|rcsb pdb:6LXT|rcsb pdb:6M0J|rcsb pdb:6W41|interpro:IPR032500|interpro:IPR043607|rcsb pdb:6M1V|rcsb pdb:6WPS|rcsb pdb:6WPT|rcsb pdb:6X29|rcsb pdb:6X2A|rcsb pdb:6X2B|rcsb pdb:6X2C|rcsb pdb:6X6P|rcsb pdb:6XC2|rcsb pdb:6XC3|rcsb pdb:6XC4|rcsb pdb:6XC7|rcsb pdb:6XCM|rcsb pdb:6XCN|rcsb pdb:6XDG|rcsb pdb:6XE1|rcsb pdb:6XEY|rcsb pdb:6XKL|rcsb pdb:6XR8|rcsb pdb:6XRA|rcsb pdb:6XS6|rcsb pdb:6YZ5|rcsb pdb:6YZ7|rcsb pdb:6Z2M|rcsb pdb:6Z43|rcsb pdb:6ZCZ|rcsb pdb:6ZDH|rcsb pdb:6ZER|rcsb pdb:6ZFO|rcsb pdb:6ZGE|rcsb pdb:6ZGG|rcsb pdb:6ZGI|rcsb pdb:6ZOX|rcsb pdb:6ZOY|rcsb pdb:6ZOZ|rcsb pdb:6ZP0|rcsb pdb:6ZP1|rcsb pdb:6ZP2|rcsb pdb:7BWJ|rcsb pdb:7BYR|rcsb pdb:7C01|rcsb pdb:7C2L|rcsb pdb:7C8V|rcsb pdb:7C8W|rcsb pdb:7CAN|rcsb pdb:6X79|rcsb pdb:6XF5|rcsb pdb:6XF6|rcsb pdb:6XLU|rcsb pdb:6XM0|rcsb pdb:6XM3|rcsb pdb:6XM4|rcsb pdb:6XM5|rcsb pdb:6Z97|rcsb pdb:6ZBP|rcsb pdb:6ZDG|rcsb pdb:6ZH9|rcsb pdb:6ZHD|rcsb pdb:6ZOW|rcsb pdb:6ZP5|rcsb pdb:6ZP7|rcsb pdb:6ZWV|rcsb pdb:7C8D|rcsb pdb:7CAH|rcsb pdb:7CN9|rcsb pdb:7JJI|rcsb pdb:7JJJ|rcsb pdb:7JMO|rcsb pdb:7JMP|rcsb pdb:6XKP|rcsb pdb:6XKQ|rcsb pdb:6ZB4|rcsb pdb:6ZB5|rcsb pdb:6ZXN|rcsb pdb:7A29|rcsb pdb:7A4N|rcsb pdb:7A5R|rcsb pdb:7A5S|rcsb pdb:7A91|rcsb pdb:7A92|rcsb pdb:7A93|rcsb pdb:7A94|rcsb pdb:7A95|rcsb pdb:7A96|rcsb pdb:7A97|rcsb pdb:7A98|rcsb pdb:7AD1|rcsb pdb:7CAI|rcsb pdb:7CAK|rcsb pdb:7CH4|rcsb pdb:7CH5|rcsb pdb:7CHB|rcsb pdb:7CHC|rcsb pdb:7CHE|rcsb pdb:7CHF|rcsb pdb:7CHH|rcsb pdb:7JJC|rcsb pdb:7JMW|rcsb pdb:7JV2|rcsb pdb:7JV4|rcsb pdb:7JV6|rcsb pdb:7JVA|rcsb pdb:7JVC|rcsb pdb:7JW0|rcsb pdb:7JWB|rcsb pdb:7JX3|rcsb pdb:7JZL|rcsb pdb:7JZM|rcsb pdb:7JZN|rcsb pdb:7JZU|rcsb pdb:7K43|rcsb pdb:7K45|rcsb pdb:7K4N|rcsb pdb:7K8S|rcsb pdb:7K8T|rcsb pdb:7K8U|rcsb pdb:7K8V|rcsb pdb:7K8W|rcsb pdb:7K8X|rcsb pdb:7K8Y|rcsb pdb:7K8Z|rcsb pdb:7K90|rcsb pdb:7K9Z|rcsb pdb:7KDG|rcsb pdb:7KDH|rcsb pdb:7KDI|rcsb pdb:7KDJ|rcsb pdb:7KDK|rcsb pdb:7KDL|rcsb pdb:7KE4|rcsb pdb:7KE6|rcsb pdb:7KE7|rcsb pdb:7KE8|rcsb pdb:7KE9|rcsb pdb:7KEA|rcsb pdb:7KEB|rcsb pdb:7KEC|reactome:R-HSA-9694322|reactome:R-HSA-9694548|reactome:R-HSA-9694614|reactome:R-HSA-9694635	ensembl:ENST00000252519(transcript)|ensembl:ENST00000427411(transcript)|ensembl:ENST00000678073(transcript)|ensembl:ENST00000680121(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0003051"(angiotensin-mediated drinking behavior)|go:"GO:0003081"(regulation of systemic arterial blood pressure by renin-angiotensin)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004180"(carboxypeptidase activity)|go:"GO:0004181"(metallocarboxypeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006508"(proteolysis)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008241"(peptidyl-dipeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0015827"(tryptophan transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|ensembl:ENSG00000130234(gene)|go:"GO:0051957"(positive regulation of amino acid transport)|go:"GO:0060452"(positive regulation of cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1905737"(positive regulation of L-proline import across plasma membrane)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR001548(Peptidase M2, peptidyl-dipeptidase A)|interpro:IPR031588|mint:Q9BYF1|rcsb pdb:1R42|rcsb pdb:1R4L|rcsb pdb:1XJP|rcsb pdb:2AJF|rcsb pdb:3D0G|rcsb pdb:3D0H|rcsb pdb:3D0I|rcsb pdb:3KBH|rcsb pdb:3SCI|rcsb pdb:3SCJ|rcsb pdb:3SCK|rcsb pdb:3SCL|rcsb pdb:6ACG|rcsb pdb:6ACJ|rcsb pdb:6ACK|rcsb pdb:6CS2|rcsb pdb:6LZG|rcsb pdb:6M0J|rcsb pdb:6M17|rcsb pdb:6M18|go:"GO:0050727"(regulation of inflammatory response)|rcsb pdb:6M1D|rcsb pdb:6VW1|rcsb pdb:7A91|rcsb pdb:7A92|rcsb pdb:7A94|rcsb pdb:7A95|rcsb pdb:7A96|rcsb pdb:7A97|rcsb pdb:7A98|rcsb pdb:7BH9|rcsb pdb:7CT5|rcsb pdb:7DDO|rcsb pdb:7DDP|rcsb pdb:7DF4|rcsb pdb:7DMU|rcsb pdb:7DWX|rcsb pdb:7DX4|rcsb pdb:7DX5|rcsb pdb:7DX6|rcsb pdb:7DX7|rcsb pdb:7DX8|rcsb pdb:7DX9|rcsb pdb:7JVO|rcsb pdb:7KJ2|rcsb pdb:7KJ3|rcsb pdb:7KJ4|rcsb pdb:7KMB|rcsb pdb:7KMS|rcsb pdb:7KMZ|rcsb pdb:7KNB|rcsb pdb:7KNE|rcsb pdb:7KNH|rcsb pdb:7L0N|rcsb pdb:7L7F|rcsb pdb:7LO4|rcsb pdb:7MJM|rcsb pdb:7MJN|rcsb pdb:7NXC|reactome:R-HSA-2022377|reactome:R-HSA-9678110|reactome:R-HSA-9679191|reactome:R-HSA-9694614|rcsb pdb:7KNI|dip:DIP-44689N|refseq:NP_068576.1	-	-	comment:mint|function:Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses	figure legend:Supp. figure 1|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/06/29	2020/12/07	rogid:QpTiyy2B+5c9PtFcZD+nZTX7nng2697049	rogid:ZxuR6gzxz4Ns+hYH5uksGdn8S7o9606	rigid:ifvi7ujE/umoOOd5Y9t9R/Xwrq8	false	sufficient binding region:319-541|his tag:c-c	fc-igg tag:c-c|sufficient binding region:1..18-740	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P0DTC2	uniprotkb:P02751	intact:EBI-25474821	intact:EBI-1220319|uniprotkb:Q7Z391|uniprotkb:O95609|uniprotkb:O95610|uniprotkb:Q14312|uniprotkb:Q14325|uniprotkb:Q14326|uniprotkb:Q17RV7|uniprotkb:Q585T2|uniprotkb:Q59EH1|uniprotkb:Q60FE4|uniprotkb:Q68DP8|uniprotkb:Q68DP9|uniprotkb:Q68DT4|uniprotkb:Q6LDP6|uniprotkb:Q6MZU5|uniprotkb:Q6N025|uniprotkb:Q6N0A6|uniprotkb:Q86T27|uniprotkb:Q8IVI8|uniprotkb:Q96KP7|uniprotkb:Q96KP8|uniprotkb:Q96KP9|uniprotkb:Q9H1B8|uniprotkb:Q9HAP3|uniprotkb:Q9UMK2|uniprotkb:Q6MZS0|uniprotkb:B7ZLF0|uniprotkb:E9PE77|uniprotkb:E9PG29|uniprotkb:Q564H7|uniprotkb:Q53S27|ensembl:ENSP00000346839	psi-mi:spike_sars2(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name)	psi-mi:finc_human(display_long)|uniprotkb:FN1(gene name)|psi-mi:FN1(display_short)|uniprotkb:FN(gene name synonym)|uniprotkb:Cold-insoluble globulin(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Beddingfield et al. (2020)	pubmed:33102950|imex:IM-28488	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26430094|imex:IM-28488-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR043002|interpro:IPR044873|rcsb pdb:7MJI|rcsb pdb:7MJJ|rcsb pdb:7MJK|rcsb pdb:7MJL|rcsb pdb:7MJM|rcsb pdb:7MJN|rcsb pdb:7MKB|rcsb pdb:7MKL|rcsb pdb:7MKM|rcsb pdb:7MMO|rcsb pdb:7MY2|rcsb pdb:7MY3|rcsb pdb:7N0G|rcsb pdb:7N0H|rcsb pdb:7NEG|rcsb pdb:7NKT|rcsb pdb:7NT9|rcsb pdb:7NTA|rcsb pdb:7NTC|rcsb pdb:7NX6|rcsb pdb:7NX7|rcsb pdb:7NX8|rcsb pdb:7NX9|rcsb pdb:7NXA|rcsb pdb:7NXB|rcsb pdb:7NXC|rcsb pdb:7AKD|rcsb pdb:7B14|rcsb pdb:7B18|rcsb pdb:7B62|rcsb pdb:7C53|rcsb pdb:7CHO|rcsb pdb:7CHP|rcsb pdb:7CHS|rcsb pdb:7CN4|rcsb pdb:7CWT|rcsb pdb:7CYH|rcsb pdb:7CYP|rcsb pdb:7CZP|rcsb pdb:7CZQ|rcsb pdb:7CZR|rcsb pdb:7CZS|rcsb pdb:7CZT|rcsb pdb:7CZU|rcsb pdb:7CZV|rcsb pdb:7CZW|rcsb pdb:7CZX|rcsb pdb:7CZY|rcsb pdb:7CZZ|rcsb pdb:7D00|rcsb pdb:7D03|rcsb pdb:7D0B|rcsb pdb:7D0C|rcsb pdb:7D0D|rcsb pdb:7D4G|rcsb pdb:7DEO|rcsb pdb:7DET|rcsb pdb:7DEU|interpro:IPR044874|rcsb pdb:7DJZ|rcsb pdb:7DK0|rcsb pdb:7DWX|rcsb pdb:7DWY|rcsb pdb:7DWZ|rcsb pdb:7DX0|rcsb pdb:7DX1|rcsb pdb:7DX2|rcsb pdb:7DX3|rcsb pdb:7DX4|rcsb pdb:7DX5|rcsb pdb:7DX6|rcsb pdb:7DX7|rcsb pdb:7DX8|rcsb pdb:7DX9|rcsb pdb:7DZW|rcsb pdb:7DZX|rcsb pdb:7DZY|rcsb pdb:7E23|rcsb pdb:7E3J|rcsb pdb:7E5Y|rcsb pdb:7E7B|rcsb pdb:7E7D|rcsb pdb:7E7X|rcsb pdb:7E7Y|rcsb pdb:7E86|rcsb pdb:7E88|rcsb pdb:7E8C|rcsb pdb:7E8F|rcsb pdb:7E8M|rcsb pdb:7EAM|rcsb pdb:7EAN|rcsb pdb:7EAZ|rcsb pdb:7EB0|rcsb pdb:7EB3|rcsb pdb:7EB4|rcsb pdb:7EB5|rcsb pdb:7EJ4|rcsb pdb:7EJ5|rcsb pdb:7EK6|rcsb pdb:7KFV|rcsb pdb:7KFW|rcsb pdb:7KFX|rcsb pdb:7KFY|rcsb pdb:7KQB|rcsb pdb:7KQE|rcsb pdb:7KRQ|rcsb pdb:7KRR|rcsb pdb:7KRS|rcsb pdb:7L2D|rcsb pdb:7L2E|rcsb pdb:7L2F|rcsb pdb:7L4Z|rcsb pdb:7L56|rcsb pdb:7L57|rcsb pdb:7L58|rcsb pdb:7LAA|rcsb pdb:7LAB|rcsb pdb:7LC8|rcsb pdb:7LDJ|rcsb pdb:7LJR|rcsb pdb:7LM8|rcsb pdb:7LO4|rcsb pdb:7LQV|rcsb pdb:7LQW|rcsb pdb:7LS9|rcsb pdb:7LSS|rcsb pdb:7LWI|rcsb pdb:7LWJ|rcsb pdb:7LWK|rcsb pdb:7LWL|rcsb pdb:7LWM|rcsb pdb:7LWN|rcsb pdb:7LWO|rcsb pdb:7LWP|rcsb pdb:7LWQ|rcsb pdb:7LWS|rcsb pdb:7LWT|rcsb pdb:7LWU|rcsb pdb:7LWV|rcsb pdb:7LWW|rcsb pdb:7LX5|rcsb pdb:7LXW|rcsb pdb:7LXX|rcsb pdb:7LXY|rcsb pdb:7LXZ|rcsb pdb:7LY0|rcsb pdb:7LY2|rcsb pdb:7LY3|rcsb pdb:7LYK|rcsb pdb:7LYL|rcsb pdb:7LYM|rcsb pdb:7LYN|rcsb pdb:7LYO|rcsb pdb:7LYP|rcsb pdb:7LYQ|rcsb pdb:7M0J|rcsb pdb:7M6D|rcsb pdb:7M6E|rcsb pdb:7M6F|rcsb pdb:7M6G|rcsb pdb:7M6H|rcsb pdb:7M6I|rcsb pdb:7M71|rcsb pdb:7M7B|rcsb pdb:7M7W|rcsb pdb:7M8J|rcsb pdb:7M8K|rcsb pdb:7M8S|rcsb pdb:7M8T|rcsb pdb:7M8U|rcsb pdb:7MF1|rcsb pdb:7MFU|rcsb pdb:7M3I|rcsb pdb:7M53|rcsb pdb:7MJG|rcsb pdb:7MJH|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|interpro:IPR043473|rcsb pdb:6LZG|rcsb pdb:6VW1|rcsb pdb:6YLA|rcsb pdb:6YM0|rcsb pdb:6YOR|rcsb pdb:7BZ5|refseq:YP_009724390.1|rcsb pdb:7KMG|rcsb pdb:7KMH|rcsb pdb:7KMI|rcsb pdb:7KMK|rcsb pdb:7KML|rcsb pdb:7KN5|rcsb pdb:7KN6|rcsb pdb:7KN7|rcsb pdb:7KS9|rcsb pdb:7KSG|rcsb pdb:7KXJ|rcsb pdb:7KXK|rcsb pdb:7KZB|rcsb pdb:7L0N|rcsb pdb:7L2C|rcsb pdb:7L3N|rcsb pdb:7L5B|rcsb pdb:7L7F|rcsb pdb:7L7K|rcsb pdb:7LCN|rcsb pdb:7LD1|rcsb pdb:7LOP|rcsb pdb:7ND3|rcsb pdb:7ND4|rcsb pdb:7ND5|rcsb pdb:7ND6|rcsb pdb:7ND7|rcsb pdb:7ND8|rcsb pdb:7ND9|rcsb pdb:7NDA|rcsb pdb:7NDB|rcsb pdb:7NDC|rcsb pdb:7NDD|rcsb pdb:7NEH|rcsb pdb:7B17|rcsb pdb:7BEH|rcsb pdb:7BEI|rcsb pdb:7BEJ|rcsb pdb:7BEK|rcsb pdb:7BEL|rcsb pdb:7BEM|rcsb pdb:7BEN|rcsb pdb:7BEO|rcsb pdb:7BEP|rcsb pdb:7C8J|rcsb pdb:7CAC|rcsb pdb:7CM4|rcsb pdb:7CWL|rcsb pdb:7D2Z|rcsb pdb:7D30|rcsb pdb:7DPM|rcsb pdb:7KGJ|rcsb pdb:7KGK|rcsb pdb:7KLG|rcsb pdb:7KLH|rcsb pdb:7KLW|interpro:IPR042578|rcsb pdb:7CAB|interpro:IPR044341|rcsb pdb:7CDI|interpro:IPR044366|rcsb pdb:7CDJ|rcsb pdb:6ZLR|rcsb pdb:7CJF|rcsb pdb:7CT5|rcsb pdb:7A25|rcsb pdb:7CWM|rcsb pdb:7CWN|rcsb pdb:7CWO|rcsb pdb:7CWS|rcsb pdb:7CWU|rcsb pdb:7DCC|rcsb pdb:7DCX|rcsb pdb:7DD2|rcsb pdb:7DD8|rcsb pdb:7DDD|rcsb pdb:7DDN|rcsb pdb:7DF3|rcsb pdb:7DF4|rcsb pdb:7DK3|rcsb pdb:7DK4|rcsb pdb:7DK5|rcsb pdb:7DK6|rcsb pdb:7DK7|rcsb pdb:7DMU|rcsb pdb:7JVB|rcsb pdb:7JWY|rcsb pdb:7K8M|rcsb pdb:7KJ2|rcsb pdb:7KJ3|rcsb pdb:7KJ4|rcsb pdb:7KJ5|rcsb pdb:7KKK|rcsb pdb:7KKL|rcsb pdb:7KL9|rcsb pdb:7KMB|rcsb pdb:7KMS|rcsb pdb:7KMZ|rcsb pdb:7KNB|rcsb pdb:7KNE|rcsb pdb:7KNH|rcsb pdb:7KNI|rcsb pdb:7L02|rcsb pdb:7L06|rcsb pdb:7L09|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR036326|rcsb pdb:6M17|rcsb pdb:6VSB|rcsb pdb:6VXX|rcsb pdb:6VYB|rcsb pdb:6LVN|rcsb pdb:6LXT|rcsb pdb:6M0J|rcsb pdb:6W41|interpro:IPR032500|interpro:IPR043607|rcsb pdb:6M1V|rcsb pdb:6WPS|rcsb pdb:6WPT|rcsb pdb:6X29|rcsb pdb:6X2A|rcsb pdb:6X2B|rcsb pdb:6X2C|rcsb pdb:6X6P|rcsb pdb:6XC2|rcsb pdb:6XC3|rcsb pdb:6XC4|rcsb pdb:6XC7|rcsb pdb:6XCM|rcsb pdb:6XCN|rcsb pdb:6XDG|rcsb pdb:6XE1|rcsb pdb:6XEY|rcsb pdb:6XKL|rcsb pdb:6XR8|rcsb pdb:6XRA|rcsb pdb:6XS6|rcsb pdb:6YZ5|rcsb pdb:6YZ7|rcsb pdb:6Z2M|rcsb pdb:6Z43|rcsb pdb:6ZCZ|rcsb pdb:6ZDH|rcsb pdb:6ZER|rcsb pdb:6ZFO|rcsb pdb:6ZGE|rcsb pdb:6ZGG|rcsb pdb:6ZGI|rcsb pdb:6ZOX|rcsb pdb:6ZOY|rcsb pdb:6ZOZ|rcsb pdb:6ZP0|rcsb pdb:6ZP1|rcsb pdb:6ZP2|rcsb pdb:7BWJ|rcsb pdb:7BYR|rcsb pdb:7C01|rcsb pdb:7C2L|rcsb pdb:7C8V|rcsb pdb:7C8W|rcsb pdb:7CAN|rcsb pdb:6X79|rcsb pdb:6XF5|rcsb pdb:6XF6|rcsb pdb:6XLU|rcsb pdb:6XM0|rcsb pdb:6XM3|rcsb pdb:6XM4|rcsb pdb:6XM5|rcsb pdb:6Z97|rcsb pdb:6ZBP|rcsb pdb:6ZDG|rcsb pdb:6ZH9|rcsb pdb:6ZHD|rcsb pdb:6ZOW|rcsb pdb:6ZP5|rcsb pdb:6ZP7|rcsb pdb:6ZWV|rcsb pdb:7C8D|rcsb pdb:7CAH|rcsb pdb:7CN9|rcsb pdb:7JJI|rcsb pdb:7JJJ|rcsb pdb:7JMO|rcsb pdb:7JMP|rcsb pdb:6XKP|rcsb pdb:6XKQ|rcsb pdb:6ZB4|rcsb pdb:6ZB5|rcsb pdb:6ZXN|rcsb pdb:7A29|rcsb pdb:7A4N|rcsb pdb:7A5R|rcsb pdb:7A5S|rcsb pdb:7A91|rcsb pdb:7A92|rcsb pdb:7A93|rcsb pdb:7A94|rcsb pdb:7A95|rcsb pdb:7A96|rcsb pdb:7A97|rcsb pdb:7A98|rcsb pdb:7AD1|rcsb pdb:7CAI|rcsb pdb:7CAK|rcsb pdb:7CH4|rcsb pdb:7CH5|rcsb pdb:7CHB|rcsb pdb:7CHC|rcsb pdb:7CHE|rcsb pdb:7CHF|rcsb pdb:7CHH|rcsb pdb:7JJC|rcsb pdb:7JMW|rcsb pdb:7JV2|rcsb pdb:7JV4|rcsb pdb:7JV6|rcsb pdb:7JVA|rcsb pdb:7JVC|rcsb pdb:7JW0|rcsb pdb:7JWB|rcsb pdb:7JX3|rcsb pdb:7JZL|rcsb pdb:7JZM|rcsb pdb:7JZN|rcsb pdb:7JZU|rcsb pdb:7K43|rcsb pdb:7K45|rcsb pdb:7K4N|rcsb pdb:7K8S|rcsb pdb:7K8T|rcsb pdb:7K8U|rcsb pdb:7K8V|rcsb pdb:7K8W|rcsb pdb:7K8X|rcsb pdb:7K8Y|rcsb pdb:7K8Z|rcsb pdb:7K90|rcsb pdb:7K9Z|rcsb pdb:7KDG|rcsb pdb:7KDH|rcsb pdb:7KDI|rcsb pdb:7KDJ|rcsb pdb:7KDK|rcsb pdb:7KDL|rcsb pdb:7KE4|rcsb pdb:7KE6|rcsb pdb:7KE7|rcsb pdb:7KE8|rcsb pdb:7KE9|rcsb pdb:7KEA|rcsb pdb:7KEB|rcsb pdb:7KEC|reactome:R-HSA-9694322|reactome:R-HSA-9694548|reactome:R-HSA-9694614|reactome:R-HSA-9694635	refseq:NP_002017.1|refseq:NP_473375.2|refseq:NP_997639.1|refseq:NP_997641.1|refseq:NP_997643.1|refseq:NP_997647.1|refseq:NP_001293058.1|refseq:NP_001293059.1|refseq:NP_001293060.1|refseq:NP_001293061.1|refseq:XP_005246463.1|dip:DIP-29547N|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019899"(enzyme binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0033622"(integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|ensembl:ENSG00000115414(gene)|ensembl:ENST00000354785(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006953"(acute-phase response)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|interpro:IPR000083(Fibronectin, type I)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036116|interpro:IPR036943|mint:P02751|rcsb pdb:1E88|rcsb pdb:1E8B|rcsb pdb:1FBR|rcsb pdb:1FNA|rcsb pdb:1FNF|rcsb pdb:1FNH|rcsb pdb:1J8K|rcsb pdb:1O9A|rcsb pdb:1OWW|rcsb pdb:1Q38|rcsb pdb:1QGB|rcsb pdb:1QO6|rcsb pdb:1TTF|rcsb pdb:1TTG|rcsb pdb:2CG6|rcsb pdb:2CG7|rcsb pdb:2CK2|rcsb pdb:2CKU|rcsb pdb:2EC3|rcsb pdb:2FN2|rcsb pdb:2FNB|rcsb pdb:2GEE|rcsb pdb:2H41|rcsb pdb:2H45|rcsb pdb:2HA1|rcsb pdb:2MNU|rcsb pdb:2N1K|rcsb pdb:2OCF|rcsb pdb:2RKY|rcsb pdb:2RKZ|rcsb pdb:2RL0|rcsb pdb:3CAL|rcsb pdb:3EJH|rcsb pdb:3GXE|rcsb pdb:3M7P|rcsb pdb:3MQL|rcsb pdb:3R8Q|rcsb pdb:3T1W|rcsb pdb:3ZRZ|rcsb pdb:4GH7|rcsb pdb:4JE4|rcsb pdb:4JEG|rcsb pdb:4LXO|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|rcsb pdb:4PZ5|rcsb pdb:5DC0|rcsb pdb:5DC4|rcsb pdb:5DC9|rcsb pdb:5DFT|rcsb pdb:5J6Z|rcsb pdb:5J7C|rcsb pdb:5M0A|rcsb pdb:5N47|rcsb pdb:5N48|rcsb pdb:6HNF|rcsb pdb:6MFA|rcsb pdb:6MSV|rcsb pdb:6NAJ|rcsb pdb:6XAX|rcsb pdb:6XAY|rcsb pdb:7NWL|reactome:R-HSA-114608|reactome:R-HSA-1474228|reactome:R-HSA-1474244|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381426|reactome:R-HSA-5674135|reactome:R-HSA-6785807|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8874081|reactome:R-HSA-8957275|reactome:R-HSA-9649948|reactome:R-HSA-9656223	-	-	-	figure legend:Supp. figure 1|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/06/29	2020/12/07	rogid:QpTiyy2B+5c9PtFcZD+nZTX7nng2697049	rogid:4arZu49X8b+dthqaX4DIh59V8h09606	rigid:ifvi7ujE/umoOOd5Y9t9R/Xwrq8	false	sufficient binding region:319-541|his tag:c-c	N-acetyl-L-proline:1498-1498|sufficient binding region:1498-1502|mutation:1501-1501	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)