#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
intact:EBI-26452941	uniprotkb:P0DTD1-PRO_0000449619	intact:EBI-25401791	intact:EBI-25475847	psi-mi:40s_human-1(display_short)|psi-mi:EBI-26452941(display_long)|intact:SSU(complex synonym)|intact:40S cytosolic small ribosomal subunit(complex recommended name)|intact:"FAU:RACK1:RPSA:RPS2:RPS3:RPS3A:RPS4X:RPS4Y1:RPS4Y2:RPS5:RPS6:RPS7:RPS8:RPS9:RPS10:RPS11:RPS12:RPS13:RPS14:RPS15:RPS15A:RPS16:RPS17:RPS18:RPS19:RPS20:RPS21:RPS23:RPS24:RPS25:RPS26:RPS27:RPS27A:RPS27L:RPS28:RPS29"(complex systematic name)	psi-mi:p0dtd1-pro_0000449619(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0410"(3D electron microscopy)	Ming et al. (2020)	pubmed:32995777|doi:10.1101/2020.09.18.302901|imex:IM-28355	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26353697|imex:IM-28355-1|pdbe:7K5I|emdb:EMD-22681	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	evidence ontology:"ECO:0005547"|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0045182"(translation regulator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0000049"(tRNA binding)|pubmed:30075139(see-also)|pubmed:25901680(see-also)|complex portal:CPX-5223(complex-primary)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	curated-complex:"Component of the ribosome, the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). Acts as the decoding centre of the ribosome which brings mRNA and aminoacylated transfer (t)RNAs together, with the 16S ribosomal (r)RNA being  required for the selection of the cognate tRNA."|complex-properties:"The human ribosome (80S) has a molecular weight of 4.3 MDa: the large subunit (60S) (CPX-5183) consists of 28S, 5S and 5.8S rRNAs and 47 ribonucleproteins (RPs), while the small subunit (40S) possesses a single 18S rRNA chain and 33 RPs.     Unlike yeast, in which the majority of RPs have paralogs due to genome duplications, only two of RPs have paralogs in humans.   Some RP paralogs are shown to have different tissue specificity and, as in some case, to be mutual exclusive.   Ribosome heterogeneity is not unique to the protein components of the ribosome: it can also occur at the level of rRNA. The rRNAs are encoded by multiple copies of ribosomal DNA (rDNA) on different chromosomes. Distinct rRNA usage has been suggested to correlate with different developmental stages.     The core of the 40S subunit is formed by the 18S ribosomal RNA, whilst the ribosomal proteins create binding sites for the mRNA and the tRNA A-site, P-site and E-site. Whilst there is normally considered to be a single copy of each polymer in the mature ribosome, there is evidence that the composition can vary in response to physiological conditions, potentially altering the translational efficiency of distinct mRNAs."	chain-seq-start:1|chain-seq-end:180	figure legend:Fig. 1e|comment:"PDBe also lists RPL41 (UniprotKB P62945) as part of 40S ribosomal complex; but it appears to be part of 60S complex. So RPL41 has been added as a separate participant."|caution:There is lack of consistency on the host organism of purified human ribosomes - the authors mention that ribosomes were purified from Expi293 cells, but ref. 14 and possibly the  figure legend states HeLa as the source.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/09/21	2020/12/16	-	rogid:SaSNaqNfTqsYEpmhXnBT8bJZczM2697049	-	false	-	his tag:n-n|maltose binding protein tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-26452941	uniprotkb:P62945-PRO_0000198055	intact:EBI-25401791	intact:EBI-26501165	psi-mi:40s_human-1(display_short)|psi-mi:EBI-26452941(display_long)|intact:SSU(complex synonym)|intact:40S cytosolic small ribosomal subunit(complex recommended name)|intact:"FAU:RACK1:RPSA:RPS2:RPS3:RPS3A:RPS4X:RPS4Y1:RPS4Y2:RPS5:RPS6:RPS7:RPS8:RPS9:RPS10:RPS11:RPS12:RPS13:RPS14:RPS15:RPS15A:RPS16:RPS17:RPS18:RPS19:RPS20:RPS21:RPS23:RPS24:RPS25:RPS26:RPS27:RPS27A:RPS27L:RPS28:RPS29"(complex systematic name)	psi-mi:p62945-pro_0000198055(display_long)|uniprotkb:RPL41(gene name)|psi-mi:RPL41(display_short)|uniprotkb:HG12(gene name synonym)|uniprotkb:Large ribosomal subunit protein eL41(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Ming et al. (2020)	pubmed:32995777|doi:10.1101/2020.09.18.302901|imex:IM-28355	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26353697|imex:IM-28355-1|pdbe:7K5I|emdb:EMD-22681	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	evidence ontology:"ECO:0005547"|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0045182"(translation regulator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0000049"(tRNA binding)|pubmed:30075139(see-also)|pubmed:25901680(see-also)|complex portal:CPX-5223(complex-primary)	intact:EBI-2116899(chain-parent)	-	curated-complex:"Component of the ribosome, the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). Acts as the decoding centre of the ribosome which brings mRNA and aminoacylated transfer (t)RNAs together, with the 16S ribosomal (r)RNA being  required for the selection of the cognate tRNA."|complex-properties:"The human ribosome (80S) has a molecular weight of 4.3 MDa: the large subunit (60S) (CPX-5183) consists of 28S, 5S and 5.8S rRNAs and 47 ribonucleproteins (RPs), while the small subunit (40S) possesses a single 18S rRNA chain and 33 RPs.     Unlike yeast, in which the majority of RPs have paralogs due to genome duplications, only two of RPs have paralogs in humans.   Some RP paralogs are shown to have different tissue specificity and, as in some case, to be mutual exclusive.   Ribosome heterogeneity is not unique to the protein components of the ribosome: it can also occur at the level of rRNA. The rRNAs are encoded by multiple copies of ribosomal DNA (rDNA) on different chromosomes. Distinct rRNA usage has been suggested to correlate with different developmental stages.     The core of the 40S subunit is formed by the 18S ribosomal RNA, whilst the ribosomal proteins create binding sites for the mRNA and the tRNA A-site, P-site and E-site. Whilst there is normally considered to be a single copy of each polymer in the mature ribosome, there is evidence that the composition can vary in response to physiological conditions, potentially altering the translational efficiency of distinct mRNAs."	chain-seq-start:1|chain-seq-end:25	figure legend:Fig. 1e|comment:"PDBe also lists RPL41 (UniprotKB P62945) as part of 40S ribosomal complex; but it appears to be part of 60S complex. So RPL41 has been added as a separate participant."|caution:There is lack of consistency on the host organism of purified human ribosomes - the authors mention that ribosomes were purified from Expi293 cells, but ref. 14 and possibly the  figure legend states HeLa as the source.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/09/21	2020/12/16	-	rogid:SU5jQlPxYXqQl/QmDBfqw815fP09606	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-26452941	intact:EBI-15182334	intact:EBI-25401791	rnacentral:URS0000704D22_9606|hgnc:"HGNC:37657"	psi-mi:40s_human-1(display_short)|psi-mi:EBI-26452941(display_long)|intact:SSU(complex synonym)|intact:40S cytosolic small ribosomal subunit(complex recommended name)|intact:"FAU:RACK1:RPSA:RPS2:RPS3:RPS3A:RPS4X:RPS4Y1:RPS4Y2:RPS5:RPS6:RPS7:RPS8:RPS9:RPS10:RPS11:RPS12:RPS13:RPS14:RPS15:RPS15A:RPS16:RPS17:RPS18:RPS19:RPS20:RPS21:RPS23:RPS24:RPS25:RPS26:RPS27:RPS27A:RPS27L:RPS28:RPS29"(complex systematic name)	psi-mi:rrna18s human(display_short)|psi-mi:EBI-15182334(display_long)	psi-mi:"MI:0410"(3D electron microscopy)	Ming et al. (2020)	pubmed:32995777|doi:10.1101/2020.09.18.302901|imex:IM-28355	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26353697|imex:IM-28355-1|pdbe:7K5I|emdb:EMD-22681	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0608"(ribosomal rna)	evidence ontology:"ECO:0005547"|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0045182"(translation regulator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0000049"(tRNA binding)|pubmed:30075139(see-also)|pubmed:25901680(see-also)|complex portal:CPX-5223(complex-primary)	-	-	curated-complex:"Component of the ribosome, the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). Acts as the decoding centre of the ribosome which brings mRNA and aminoacylated transfer (t)RNAs together, with the 16S ribosomal (r)RNA being  required for the selection of the cognate tRNA."|complex-properties:"The human ribosome (80S) has a molecular weight of 4.3 MDa: the large subunit (60S) (CPX-5183) consists of 28S, 5S and 5.8S rRNAs and 47 ribonucleproteins (RPs), while the small subunit (40S) possesses a single 18S rRNA chain and 33 RPs.     Unlike yeast, in which the majority of RPs have paralogs due to genome duplications, only two of RPs have paralogs in humans.   Some RP paralogs are shown to have different tissue specificity and, as in some case, to be mutual exclusive.   Ribosome heterogeneity is not unique to the protein components of the ribosome: it can also occur at the level of rRNA. The rRNAs are encoded by multiple copies of ribosomal DNA (rDNA) on different chromosomes. Distinct rRNA usage has been suggested to correlate with different developmental stages.     The core of the 40S subunit is formed by the 18S ribosomal RNA, whilst the ribosomal proteins create binding sites for the mRNA and the tRNA A-site, P-site and E-site. Whilst there is normally considered to be a single copy of each polymer in the mature ribosome, there is evidence that the composition can vary in response to physiological conditions, potentially altering the translational efficiency of distinct mRNAs."	-	figure legend:Fig. 1e|comment:"PDBe also lists RPL41 (UniprotKB P62945) as part of 40S ribosomal complex; but it appears to be part of 60S complex. So RPL41 has been added as a separate participant."|caution:There is lack of consistency on the host organism of purified human ribosomes - the authors mention that ribosomes were purified from Expi293 cells, but ref. 14 and possibly the  figure legend states HeLa as the source.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/09/21	2020/12/16	-	-	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-26452941	uniprotkb:P0DTD1-PRO_0000449619	intact:EBI-25401791	intact:EBI-25475847	psi-mi:40s_human-1(display_short)|psi-mi:EBI-26452941(display_long)|intact:SSU(complex synonym)|intact:40S cytosolic small ribosomal subunit(complex recommended name)|intact:"FAU:RACK1:RPSA:RPS2:RPS3:RPS3A:RPS4X:RPS4Y1:RPS4Y2:RPS5:RPS6:RPS7:RPS8:RPS9:RPS10:RPS11:RPS12:RPS13:RPS14:RPS15:RPS15A:RPS16:RPS17:RPS18:RPS19:RPS20:RPS21:RPS23:RPS24:RPS25:RPS26:RPS27:RPS27A:RPS27L:RPS28:RPS29"(complex systematic name)	psi-mi:p0dtd1-pro_0000449619(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0071"(molecular sieving)	Ming et al. (2020)	pubmed:32995777|doi:10.1101/2020.09.18.302901|imex:IM-28355	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26565183|imex:IM-28355-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	evidence ontology:"ECO:0005547"|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0045182"(translation regulator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0000049"(tRNA binding)|pubmed:30075139(see-also)|pubmed:25901680(see-also)|complex portal:CPX-5223(complex-primary)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	curated-complex:"Component of the ribosome, the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). Acts as the decoding centre of the ribosome which brings mRNA and aminoacylated transfer (t)RNAs together, with the 16S ribosomal (r)RNA being  required for the selection of the cognate tRNA."|complex-properties:"The human ribosome (80S) has a molecular weight of 4.3 MDa: the large subunit (60S) (CPX-5183) consists of 28S, 5S and 5.8S rRNAs and 47 ribonucleproteins (RPs), while the small subunit (40S) possesses a single 18S rRNA chain and 33 RPs.     Unlike yeast, in which the majority of RPs have paralogs due to genome duplications, only two of RPs have paralogs in humans.   Some RP paralogs are shown to have different tissue specificity and, as in some case, to be mutual exclusive.   Ribosome heterogeneity is not unique to the protein components of the ribosome: it can also occur at the level of rRNA. The rRNAs are encoded by multiple copies of ribosomal DNA (rDNA) on different chromosomes. Distinct rRNA usage has been suggested to correlate with different developmental stages.     The core of the 40S subunit is formed by the 18S ribosomal RNA, whilst the ribosomal proteins create binding sites for the mRNA and the tRNA A-site, P-site and E-site. Whilst there is normally considered to be a single copy of each polymer in the mature ribosome, there is evidence that the composition can vary in response to physiological conditions, potentially altering the translational efficiency of distinct mRNAs."	chain-seq-start:1|chain-seq-end:180	figure legend:Fig. 1C|comment:"PDBe also lists RPL41 (UniprotKB P62945) as part of 40S ribosomal complex; but it appears to be part of 60S complex. So RPL41 has been added as a separate participant."|caution:There is lack of consistency on the host organism of purified human ribosomes - the authors mention that ribosomes were purified from Expi293 cells, but ref. 14 and possibly the  figure legend states HeLa as the source.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/09/21	2020/12/16	-	rogid:SaSNaqNfTqsYEpmhXnBT8bJZczM2697049	-	false	-	his tag:n-n|maltose binding protein tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-26452941	uniprotkb:P62945-PRO_0000198055	intact:EBI-25401791	intact:EBI-26501165	psi-mi:40s_human-1(display_short)|psi-mi:EBI-26452941(display_long)|intact:SSU(complex synonym)|intact:40S cytosolic small ribosomal subunit(complex recommended name)|intact:"FAU:RACK1:RPSA:RPS2:RPS3:RPS3A:RPS4X:RPS4Y1:RPS4Y2:RPS5:RPS6:RPS7:RPS8:RPS9:RPS10:RPS11:RPS12:RPS13:RPS14:RPS15:RPS15A:RPS16:RPS17:RPS18:RPS19:RPS20:RPS21:RPS23:RPS24:RPS25:RPS26:RPS27:RPS27A:RPS27L:RPS28:RPS29"(complex systematic name)	psi-mi:p62945-pro_0000198055(display_long)|uniprotkb:RPL41(gene name)|psi-mi:RPL41(display_short)|uniprotkb:HG12(gene name synonym)|uniprotkb:Large ribosomal subunit protein eL41(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Ming et al. (2020)	pubmed:32995777|doi:10.1101/2020.09.18.302901|imex:IM-28355	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26565183|imex:IM-28355-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	evidence ontology:"ECO:0005547"|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0045182"(translation regulator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0000049"(tRNA binding)|pubmed:30075139(see-also)|pubmed:25901680(see-also)|complex portal:CPX-5223(complex-primary)	intact:EBI-2116899(chain-parent)	-	curated-complex:"Component of the ribosome, the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). Acts as the decoding centre of the ribosome which brings mRNA and aminoacylated transfer (t)RNAs together, with the 16S ribosomal (r)RNA being  required for the selection of the cognate tRNA."|complex-properties:"The human ribosome (80S) has a molecular weight of 4.3 MDa: the large subunit (60S) (CPX-5183) consists of 28S, 5S and 5.8S rRNAs and 47 ribonucleproteins (RPs), while the small subunit (40S) possesses a single 18S rRNA chain and 33 RPs.     Unlike yeast, in which the majority of RPs have paralogs due to genome duplications, only two of RPs have paralogs in humans.   Some RP paralogs are shown to have different tissue specificity and, as in some case, to be mutual exclusive.   Ribosome heterogeneity is not unique to the protein components of the ribosome: it can also occur at the level of rRNA. The rRNAs are encoded by multiple copies of ribosomal DNA (rDNA) on different chromosomes. Distinct rRNA usage has been suggested to correlate with different developmental stages.     The core of the 40S subunit is formed by the 18S ribosomal RNA, whilst the ribosomal proteins create binding sites for the mRNA and the tRNA A-site, P-site and E-site. Whilst there is normally considered to be a single copy of each polymer in the mature ribosome, there is evidence that the composition can vary in response to physiological conditions, potentially altering the translational efficiency of distinct mRNAs."	chain-seq-start:1|chain-seq-end:25	figure legend:Fig. 1C|comment:"PDBe also lists RPL41 (UniprotKB P62945) as part of 40S ribosomal complex; but it appears to be part of 60S complex. So RPL41 has been added as a separate participant."|caution:There is lack of consistency on the host organism of purified human ribosomes - the authors mention that ribosomes were purified from Expi293 cells, but ref. 14 and possibly the  figure legend states HeLa as the source.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/09/21	2020/12/16	-	rogid:SU5jQlPxYXqQl/QmDBfqw815fP09606	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-26452941	intact:EBI-15182334	intact:EBI-25401791	rnacentral:URS0000704D22_9606|hgnc:"HGNC:37657"	psi-mi:40s_human-1(display_short)|psi-mi:EBI-26452941(display_long)|intact:SSU(complex synonym)|intact:40S cytosolic small ribosomal subunit(complex recommended name)|intact:"FAU:RACK1:RPSA:RPS2:RPS3:RPS3A:RPS4X:RPS4Y1:RPS4Y2:RPS5:RPS6:RPS7:RPS8:RPS9:RPS10:RPS11:RPS12:RPS13:RPS14:RPS15:RPS15A:RPS16:RPS17:RPS18:RPS19:RPS20:RPS21:RPS23:RPS24:RPS25:RPS26:RPS27:RPS27A:RPS27L:RPS28:RPS29"(complex systematic name)	psi-mi:rrna18s human(display_short)|psi-mi:EBI-15182334(display_long)	psi-mi:"MI:0071"(molecular sieving)	Ming et al. (2020)	pubmed:32995777|doi:10.1101/2020.09.18.302901|imex:IM-28355	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26565183|imex:IM-28355-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0608"(ribosomal rna)	evidence ontology:"ECO:0005547"|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0045182"(translation regulator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0000049"(tRNA binding)|pubmed:30075139(see-also)|pubmed:25901680(see-also)|complex portal:CPX-5223(complex-primary)	-	-	curated-complex:"Component of the ribosome, the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). Acts as the decoding centre of the ribosome which brings mRNA and aminoacylated transfer (t)RNAs together, with the 16S ribosomal (r)RNA being  required for the selection of the cognate tRNA."|complex-properties:"The human ribosome (80S) has a molecular weight of 4.3 MDa: the large subunit (60S) (CPX-5183) consists of 28S, 5S and 5.8S rRNAs and 47 ribonucleproteins (RPs), while the small subunit (40S) possesses a single 18S rRNA chain and 33 RPs.     Unlike yeast, in which the majority of RPs have paralogs due to genome duplications, only two of RPs have paralogs in humans.   Some RP paralogs are shown to have different tissue specificity and, as in some case, to be mutual exclusive.   Ribosome heterogeneity is not unique to the protein components of the ribosome: it can also occur at the level of rRNA. The rRNAs are encoded by multiple copies of ribosomal DNA (rDNA) on different chromosomes. Distinct rRNA usage has been suggested to correlate with different developmental stages.     The core of the 40S subunit is formed by the 18S ribosomal RNA, whilst the ribosomal proteins create binding sites for the mRNA and the tRNA A-site, P-site and E-site. Whilst there is normally considered to be a single copy of each polymer in the mature ribosome, there is evidence that the composition can vary in response to physiological conditions, potentially altering the translational efficiency of distinct mRNAs."	-	figure legend:Fig. 1C|comment:"PDBe also lists RPL41 (UniprotKB P62945) as part of 40S ribosomal complex; but it appears to be part of 60S complex. So RPL41 has been added as a separate participant."|caution:There is lack of consistency on the host organism of purified human ribosomes - the authors mention that ribosomes were purified from Expi293 cells, but ref. 14 and possibly the  figure legend states HeLa as the source.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/09/21	2020/12/16	-	-	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0DTD1-PRO_0000449619	intact:EBI-26353981	intact:EBI-25475847	refseq:NC_045512	psi-mi:p0dtd1-pro_0000449619(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:5'utr_sars-cov 2(display_short)|psi-mi:EBI-26353981(display_long)	psi-mi:"MI:0663"(confocal microscopy)	Ming et al. (2020)	pubmed:32995777|doi:10.1101/2020.09.18.302901|imex:IM-28355	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26355336|imex:IM-28355-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0319"(deoxyribonucleic acid)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	-	chain-seq-start:1|chain-seq-end:180	-	figure legend:Figs. 3b/e, 4c-d|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2020/09/21	2020/09/22	rogid:SaSNaqNfTqsYEpmhXnBT8bJZczM2697049	-	-	false	maltose binding protein tag:n-n|his tag:n-n	sufficient binding region:1-265|fluorescent protein tag:?-?	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0867"(tag visualisation by fluorescence)