#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9Y6K1	uniprotkb:Q9UBC3	intact:EBI-923653|uniprotkb:Q8WXU9|uniprotkb:Q86XF5|uniprotkb:Q8IZV0|uniprotkb:Q86TE8|uniprotkb:E9PEB8|ensembl:ENSP00000264709|ensembl:ENSP00000324375	intact:EBI-80125|uniprotkb:Q9UBD4|uniprotkb:Q9UJQ5|uniprotkb:Q9UKA6|uniprotkb:Q9UNE5|uniprotkb:Q9Y5R9|uniprotkb:Q9Y5S0|intact:EBI-28970262|ensembl:ENSP00000328547|uniprotkb:A2A2E2|uniprotkb:E1P5M6|uniprotkb:E1P5M7|uniprotkb:B4DSM8|uniprotkb:B4DSU1|uniprotkb:E7EN63|uniprotkb:E9PBF2	psi-mi:dnm3a_human(display_long)|uniprotkb:DNMT3A(gene name)|psi-mi:DNMT3A(display_short)|uniprotkb:DNA methyltransferase HsaIIIA(gene name synonym)|uniprotkb:Cysteine methyltransferase DNMT3A(gene name synonym)	psi-mi:dnm3b_human(display_long)|uniprotkb:DNMT3B(gene name)|psi-mi:DNMT3B(display_short)|uniprotkb:DNA methyltransferase HsaIIIB(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Xu et al. (2020)	imex:IM-28696|pubmed:32968275	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26447411|imex:IM-28696-1|wwpdb:6PA7|emdb:EMD-20281|emdb:EMD-21689	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001307821.1|refseq:NP_072046.2|refseq:NP_783328.1|refseq:NP_783329.1|refseq:XP_016859015.1|refseq:XP_016859016.1|refseq:XP_011530969.1|refseq:NP_001307822.1|refseq:NP_715640.2|refseq:XP_005264232.1|dip:DIP-38004N|refseq:XP_005264234.1|ensembl:ENSG00000119772(gene)|ensembl:ENST00000264709(transcript)|ensembl:ENST00000321117(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010288"(response to lead ion)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030182"(neuron differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0033189"(response to vitamin A)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|interpro:IPR000313(PWWP)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR018117|interpro:IPR025766|interpro:IPR029063|interpro:IPR030487|interpro:IPR040552|interpro:IPR044108|mint:Q9Y6K1|rcsb pdb:2QRV|rcsb pdb:3A1A|rcsb pdb:3A1B|rcsb pdb:3LLR|rcsb pdb:3SVM|rcsb pdb:4QBQ|rcsb pdb:4QBR|rcsb pdb:4QBS|rcsb pdb:4U7P|rcsb pdb:4U7T|rcsb pdb:5YX2|rcsb pdb:6BRR|rcsb pdb:6F57|rcsb pdb:6PA7|rcsb pdb:6W89|rcsb pdb:6W8B|rcsb pdb:6W8D|rcsb pdb:6W8J|reactome:R-HSA-212300|reactome:R-HSA-3214858|reactome:R-HSA-4655427|reactome:R-HSA-5334118|reactome:R-HSA-9710421	ensembl:ENSG00000088305(gene)|ensembl:ENST00000328111(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0009008"(DNA-methyltransferase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0031000"(response to caffeine)|go:"GO:0032355"(response to estradiol)|go:"GO:0033189"(response to vitamin A)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0071455"(cellular response to hyperoxia)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR000313(PWWP)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR018117|interpro:IPR025766|interpro:IPR029063|interpro:IPR030488|interpro:IPR040552|mint:Q9UBC3|rcsb pdb:3FLG|rcsb pdb:3QKJ|rcsb pdb:5CIU|rcsb pdb:5NR3|rcsb pdb:5NRR|rcsb pdb:5NRV|rcsb pdb:5NV0|rcsb pdb:5NV2|rcsb pdb:5NV7|rcsb pdb:5NVO|rcsb pdb:6KDA|rcsb pdb:6KDB|rcsb pdb:6KDL|rcsb pdb:6KDP|rcsb pdb:6KDT|rcsb pdb:6PA7|rcsb pdb:6R3E|rcsb pdb:6U8P|rcsb pdb:6U8V|rcsb pdb:6U8W|rcsb pdb:6U8X|rcsb pdb:5NRS|rcsb pdb:6U90|rcsb pdb:6U91|reactome:R-HSA-212300|reactome:R-HSA-427413|reactome:R-HSA-4655427|reactome:R-HSA-5334118|reactome:R-HSA-9710421|ensembl:ENST00000353855|ensembl:ENSP00000313397|ensembl:ENST00000443239|ensembl:ENSP00000403169|ensembl:ENST00000456297|ensembl:ENSP00000412305|ensembl:ENST00000201963|ensembl:ENSP00000201963|ensembl:ENSP00000328547|ensembl:ENST00000348286|ensembl:ENSP00000337764|refseq:NP_001193984.1|refseq:NP_001193985.1|refseq:NP_008823.1|refseq:NP_787044.1|refseq:NP_787045.1|refseq:NP_787046.1|dip:DIP-30000N	-	-	-	figure legend:Fig 1, Extended Data Fig 5, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/11/16	2020/11/16	rogid:rnq1Yv4tlQ1t9JXS3CfMmTlcPKE9606	rogid:xxbu/yvuQ1KnhVE/FdTh9CyA6jw9606	rigid:FET+FxYyhSKx18ASraPhSprZfFw	false	-	-	2	2	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:Q9Y6K1	uniprotkb:P06897	intact:EBI-923653|uniprotkb:Q8WXU9|uniprotkb:Q86XF5|uniprotkb:Q8IZV0|uniprotkb:Q86TE8|uniprotkb:E9PEB8|ensembl:ENSP00000264709|ensembl:ENSP00000324375	intact:EBI-1251194|uniprotkb:Q3B8I8	psi-mi:dnm3a_human(display_long)|uniprotkb:DNMT3A(gene name)|psi-mi:DNMT3A(display_short)|uniprotkb:DNA methyltransferase HsaIIIA(gene name synonym)|uniprotkb:Cysteine methyltransferase DNMT3A(gene name synonym)	psi-mi:h2a1_xenla(display_long)	psi-mi:"MI:0410"(3D electron microscopy)	Xu et al. (2020)	imex:IM-28696|pubmed:32968275	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26447411|imex:IM-28696-1|wwpdb:6PA7|emdb:EMD-20281|emdb:EMD-21689	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001307821.1|refseq:NP_072046.2|refseq:NP_783328.1|refseq:NP_783329.1|refseq:XP_016859015.1|refseq:XP_016859016.1|refseq:XP_011530969.1|refseq:NP_001307822.1|refseq:NP_715640.2|refseq:XP_005264232.1|dip:DIP-38004N|refseq:XP_005264234.1|ensembl:ENSG00000119772(gene)|ensembl:ENST00000264709(transcript)|ensembl:ENST00000321117(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010288"(response to lead ion)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030182"(neuron differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0033189"(response to vitamin A)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|interpro:IPR000313(PWWP)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR018117|interpro:IPR025766|interpro:IPR029063|interpro:IPR030487|interpro:IPR040552|interpro:IPR044108|mint:Q9Y6K1|rcsb pdb:2QRV|rcsb pdb:3A1A|rcsb pdb:3A1B|rcsb pdb:3LLR|rcsb pdb:3SVM|rcsb pdb:4QBQ|rcsb pdb:4QBR|rcsb pdb:4QBS|rcsb pdb:4U7P|rcsb pdb:4U7T|rcsb pdb:5YX2|rcsb pdb:6BRR|rcsb pdb:6F57|rcsb pdb:6PA7|rcsb pdb:6W89|rcsb pdb:6W8B|rcsb pdb:6W8D|rcsb pdb:6W8J|reactome:R-HSA-212300|reactome:R-HSA-3214858|reactome:R-HSA-4655427|reactome:R-HSA-5334118|reactome:R-HSA-9710421	refseq:NP_001089684.1|dip:DIP-39144N|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|rcsb pdb:1AOI|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1M18|rcsb pdb:1M19|rcsb pdb:1M1A|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:1ZBB|rcsb pdb:1ZLA|rcsb pdb:2FJ7|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3C1B|rcsb pdb:3C1C|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:3LJA|rcsb pdb:3MNN|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4LD9|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:4XZQ|rcsb pdb:4YS3|rcsb pdb:4Z66|rcsb pdb:4ZUX|rcsb pdb:5CP6|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5G2E|rcsb pdb:5HQ2|rcsb pdb:5MLU|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:6FQ8|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6KW5|rcsb pdb:6LTJ|rcsb pdb:6N1Z|rcsb pdb:6NE3|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6NZO|rcsb pdb:6O96|rcsb pdb:6OM3|rcsb pdb:6PA7|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6PWX|rcsb pdb:6PX1|rcsb pdb:6PX3|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6FTX|rcsb pdb:6G0L|rcsb pdb:6I84|rcsb pdb:6TDA|rcsb pdb:6TEM|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6W4L|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6Z6P|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7CRO|rcsb pdb:7CRP|rcsb pdb:7CRQ|rcsb pdb:7CRR|rcsb pdb:7K6P|rcsb pdb:7K6Q|rcsb pdb:6WZ5	-	-	-	figure legend:Fig 1, Extended Data Fig 5, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/11/16	2020/11/16	rogid:rnq1Yv4tlQ1t9JXS3CfMmTlcPKE9606	rogid:IstEQHlz7X72xddS8qj3PuOQ0H08355	rigid:FET+FxYyhSKx18ASraPhSprZfFw	false	-	-	2	2	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:Q9Y6K1	uniprotkb:P02281	intact:EBI-923653|uniprotkb:Q8WXU9|uniprotkb:Q86XF5|uniprotkb:Q8IZV0|uniprotkb:Q86TE8|uniprotkb:E9PEB8|ensembl:ENSP00000264709|ensembl:ENSP00000324375	intact:EBI-1251201|uniprotkb:Q6AZT0	psi-mi:dnm3a_human(display_long)|uniprotkb:DNMT3A(gene name)|psi-mi:DNMT3A(display_short)|uniprotkb:DNA methyltransferase HsaIIIA(gene name synonym)|uniprotkb:Cysteine methyltransferase DNMT3A(gene name synonym)	psi-mi:h2b11_xenla(display_long)	psi-mi:"MI:0410"(3D electron microscopy)	Xu et al. (2020)	imex:IM-28696|pubmed:32968275	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26447411|imex:IM-28696-1|wwpdb:6PA7|emdb:EMD-20281|emdb:EMD-21689	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001307821.1|refseq:NP_072046.2|refseq:NP_783328.1|refseq:NP_783329.1|refseq:XP_016859015.1|refseq:XP_016859016.1|refseq:XP_011530969.1|refseq:NP_001307822.1|refseq:NP_715640.2|refseq:XP_005264232.1|dip:DIP-38004N|refseq:XP_005264234.1|ensembl:ENSG00000119772(gene)|ensembl:ENST00000264709(transcript)|ensembl:ENST00000321117(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010288"(response to lead ion)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030182"(neuron differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0033189"(response to vitamin A)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|interpro:IPR000313(PWWP)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR018117|interpro:IPR025766|interpro:IPR029063|interpro:IPR030487|interpro:IPR040552|interpro:IPR044108|mint:Q9Y6K1|rcsb pdb:2QRV|rcsb pdb:3A1A|rcsb pdb:3A1B|rcsb pdb:3LLR|rcsb pdb:3SVM|rcsb pdb:4QBQ|rcsb pdb:4QBR|rcsb pdb:4QBS|rcsb pdb:4U7P|rcsb pdb:4U7T|rcsb pdb:5YX2|rcsb pdb:6BRR|rcsb pdb:6F57|rcsb pdb:6PA7|rcsb pdb:6W89|rcsb pdb:6W8B|rcsb pdb:6W8D|rcsb pdb:6W8J|reactome:R-HSA-212300|reactome:R-HSA-3214858|reactome:R-HSA-4655427|reactome:R-HSA-5334118|reactome:R-HSA-9710421	refseq:NP_001086753.1|dip:DIP-38577N|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4KHA|rcsb pdb:4LD9|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6PWX|rcsb pdb:6PX1|rcsb pdb:6PX3|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6TEM|rcsb pdb:6UGM|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6W4L|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7AT8|rcsb pdb:7CRO|rcsb pdb:7CRP|rcsb pdb:7CRQ|rcsb pdb:6PA7|rcsb pdb:7CRR|rcsb pdb:7E8I|rcsb pdb:7K6P|rcsb pdb:7K6Q|rcsb pdb:4Z66|rcsb pdb:4ZUX|rcsb pdb:5CP6|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5G2E|rcsb pdb:5HQ2|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:6FQ8|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JYL|rcsb pdb:6K01|rcsb pdb:6K1P|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:4XZQ|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6LTJ|rcsb pdb:4YS3|rcsb pdb:6N1Z|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6NZO|rcsb pdb:6O96|rcsb pdb:6OM3|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000558(Histone H2B)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|rcsb pdb:1AOI|rcsb pdb:1F66|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1M18|rcsb pdb:1M19|rcsb pdb:1M1A|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:1ZBB	-	-	-	figure legend:Fig 1, Extended Data Fig 5, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/11/16	2020/11/16	rogid:rnq1Yv4tlQ1t9JXS3CfMmTlcPKE9606	rogid:+nkA0I7sW2isaEdOjTHa7+jcsDw8355	rigid:FET+FxYyhSKx18ASraPhSprZfFw	false	-	binding-associated region:5-126|mutation:33-33	2	2	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:Q9Y6K1	uniprotkb:P84233	intact:EBI-923653|uniprotkb:Q8WXU9|uniprotkb:Q86XF5|uniprotkb:Q8IZV0|uniprotkb:Q86TE8|uniprotkb:E9PEB8|ensembl:ENSP00000264709|ensembl:ENSP00000324375	intact:EBI-350041|uniprotkb:P02295|uniprotkb:P02297|uniprotkb:P16105|uniprotkb:P17269|uniprotkb:A4FVE2|uniprotkb:P17320	psi-mi:dnm3a_human(display_long)|uniprotkb:DNMT3A(gene name)|psi-mi:DNMT3A(display_short)|uniprotkb:DNA methyltransferase HsaIIIA(gene name synonym)|uniprotkb:Cysteine methyltransferase DNMT3A(gene name synonym)	psi-mi:h32_xenla(display_long)	psi-mi:"MI:0410"(3D electron microscopy)	Xu et al. (2020)	imex:IM-28696|pubmed:32968275	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26447411|imex:IM-28696-1|wwpdb:6PA7|emdb:EMD-20281|emdb:EMD-21689	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001307821.1|refseq:NP_072046.2|refseq:NP_783328.1|refseq:NP_783329.1|refseq:XP_016859015.1|refseq:XP_016859016.1|refseq:XP_011530969.1|refseq:NP_001307822.1|refseq:NP_715640.2|refseq:XP_005264232.1|dip:DIP-38004N|refseq:XP_005264234.1|ensembl:ENSG00000119772(gene)|ensembl:ENST00000264709(transcript)|ensembl:ENST00000321117(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010288"(response to lead ion)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030182"(neuron differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0033189"(response to vitamin A)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|interpro:IPR000313(PWWP)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR018117|interpro:IPR025766|interpro:IPR029063|interpro:IPR030487|interpro:IPR040552|interpro:IPR044108|mint:Q9Y6K1|rcsb pdb:2QRV|rcsb pdb:3A1A|rcsb pdb:3A1B|rcsb pdb:3LLR|rcsb pdb:3SVM|rcsb pdb:4QBQ|rcsb pdb:4QBR|rcsb pdb:4QBS|rcsb pdb:4U7P|rcsb pdb:4U7T|rcsb pdb:5YX2|rcsb pdb:6BRR|rcsb pdb:6F57|rcsb pdb:6PA7|rcsb pdb:6W89|rcsb pdb:6W8B|rcsb pdb:6W8D|rcsb pdb:6W8J|reactome:R-HSA-212300|reactome:R-HSA-3214858|reactome:R-HSA-4655427|reactome:R-HSA-5334118|reactome:R-HSA-9710421	refseq:NP_001091428.1|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5HQ2|rcsb pdb:5KGF|rcsb pdb:5MLU|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XBK|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6KW5|rcsb pdb:6NE3|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6O22|rcsb pdb:6O96|rcsb pdb:6OM3|rcsb pdb:6PA7|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6PWX|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6Z6P|rcsb pdb:7AT8|rcsb pdb:7K6P|rcsb pdb:7K6Q|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|rcsb pdb:1F66|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:1ZBB|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2HUE|rcsb pdb:2IO5|rcsb pdb:2L11|rcsb pdb:2L12|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3C1B|rcsb pdb:3C1C|rcsb pdb:3GV6|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:4ZUX|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:5BS7|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:5BSA|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:5CP6|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4EO5|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4LD9|rcsb pdb:4QEO|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:4XZQ|rcsb pdb:4YS3|rcsb pdb:4Z66|refseq:XP_018079657.1|refseq:XP_018096294.1|refseq:XP_018096295.1|refseq:XP_018096296.1|refseq:XP_018098036.1|refseq:XP_018118226.1|refseq:XP_018118227.1|dip:DIP-37430N	-	-	-	figure legend:Fig 1, Extended Data Fig 5, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/11/16	2020/11/16	rogid:rnq1Yv4tlQ1t9JXS3CfMmTlcPKE9606	rogid:2TuVqWkeAnhHR4nrl0GNyUj1N3o8355	rigid:FET+FxYyhSKx18ASraPhSprZfFw	false	-	-	2	2	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:Q9Y6K1	uniprotkb:P62799	intact:EBI-923653|uniprotkb:Q8WXU9|uniprotkb:Q86XF5|uniprotkb:Q8IZV0|uniprotkb:Q86TE8|uniprotkb:E9PEB8|ensembl:ENSP00000264709|ensembl:ENSP00000324375	intact:EBI-302085|uniprotkb:P02304|uniprotkb:P02305|uniprotkb:Q6AZG5	psi-mi:dnm3a_human(display_long)|uniprotkb:DNMT3A(gene name)|psi-mi:DNMT3A(display_short)|uniprotkb:DNA methyltransferase HsaIIIA(gene name synonym)|uniprotkb:Cysteine methyltransferase DNMT3A(gene name synonym)	psi-mi:h4_xenla(display_long)	psi-mi:"MI:0410"(3D electron microscopy)	Xu et al. (2020)	imex:IM-28696|pubmed:32968275	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26447411|imex:IM-28696-1|wwpdb:6PA7|emdb:EMD-20281|emdb:EMD-21689	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001307821.1|refseq:NP_072046.2|refseq:NP_783328.1|refseq:NP_783329.1|refseq:XP_016859015.1|refseq:XP_016859016.1|refseq:XP_011530969.1|refseq:NP_001307822.1|refseq:NP_715640.2|refseq:XP_005264232.1|dip:DIP-38004N|refseq:XP_005264234.1|ensembl:ENSG00000119772(gene)|ensembl:ENST00000264709(transcript)|ensembl:ENST00000321117(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010288"(response to lead ion)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030182"(neuron differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0033189"(response to vitamin A)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|interpro:IPR000313(PWWP)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR018117|interpro:IPR025766|interpro:IPR029063|interpro:IPR030487|interpro:IPR040552|interpro:IPR044108|mint:Q9Y6K1|rcsb pdb:2QRV|rcsb pdb:3A1A|rcsb pdb:3A1B|rcsb pdb:3LLR|rcsb pdb:3SVM|rcsb pdb:4QBQ|rcsb pdb:4QBR|rcsb pdb:4QBS|rcsb pdb:4U7P|rcsb pdb:4U7T|rcsb pdb:5YX2|rcsb pdb:6BRR|rcsb pdb:6F57|rcsb pdb:6PA7|rcsb pdb:6W89|rcsb pdb:6W8B|rcsb pdb:6W8D|rcsb pdb:6W8J|reactome:R-HSA-212300|reactome:R-HSA-3214858|reactome:R-HSA-4655427|reactome:R-HSA-5334118|reactome:R-HSA-9710421	go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR001951(Histone H4)|interpro:IPR004823("TATA box binding protein associated factor (TAF)")|interpro:IPR009072(Histone-fold)|interpro:IPR019809|interpro:IPR035425|rcsb pdb:1AOI|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1M18|rcsb pdb:1M19|rcsb pdb:1M1A|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:5BSA|rcsb pdb:5CP6|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5HQ2|rcsb pdb:5KGF|rcsb pdb:5MLU|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:1ZBB|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2HUE|rcsb pdb:2IO5|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3C1B|rcsb pdb:3C1C|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4EO5|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4LD9|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:4XZQ|rcsb pdb:4YS3|rcsb pdb:4Z66|rcsb pdb:4ZBJ|rcsb pdb:4ZUX|rcsb pdb:5BS7|rcsb pdb:6FQ8|rcsb pdb:6PWW|rcsb pdb:6FTX|rcsb pdb:6G0L|rcsb pdb:6GYT|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JYL|rcsb pdb:6K1P|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6KW5|rcsb pdb:6LTJ|rcsb pdb:6NE3|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6NZO|rcsb pdb:6O22|rcsb pdb:6O96|rcsb pdb:6OM3|rcsb pdb:6PA7|rcsb pdb:6PWV|refseq:NP_001087926.1|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7AT8|rcsb pdb:7CRO|rcsb pdb:7CRP|rcsb pdb:7CRQ|rcsb pdb:7CRR|rcsb pdb:7E8I|rcsb pdb:7K6P|rcsb pdb:7K6Q|rcsb pdb:7KTQ|rcsb pdb:6PWX|rcsb pdb:6PX1|rcsb pdb:6PX3|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6TEM|rcsb pdb:6UGM|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6VZ4|rcsb pdb:6W5I|dip:DIP-37429N|refseq:XP_018095104.1|refseq:XP_018095605.1|refseq:XP_018095606.1|refseq:XP_018096302.1|refseq:XP_018097458.1|refseq:XP_018098137.1|refseq:XP_018118237.1|refseq:XP_018120359.1|refseq:XP_018120360.1	-	-	-	figure legend:Fig 1, Extended Data Fig 5, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/11/16	2020/11/16	rogid:rnq1Yv4tlQ1t9JXS3CfMmTlcPKE9606	rogid:LZSfhrpw0PcDREEoJ1UMkBvnUfA8355	rigid:FET+FxYyhSKx18ASraPhSprZfFw	false	-	-	2	2	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P06897	uniprotkb:P02281	intact:EBI-1251194|uniprotkb:Q3B8I8	intact:EBI-1251201|uniprotkb:Q6AZT0	psi-mi:h2a1_xenla(display_long)	psi-mi:h2b11_xenla(display_long)	psi-mi:"MI:0071"(molecular sieving)	Xu et al. (2020)	imex:IM-28696|pubmed:32968275	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26447436|imex:IM-28696-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001089684.1|dip:DIP-39144N|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|rcsb pdb:1AOI|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1M18|rcsb pdb:1M19|rcsb pdb:1M1A|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:1ZBB|rcsb pdb:1ZLA|rcsb pdb:2FJ7|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3C1B|rcsb pdb:3C1C|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:3LJA|rcsb pdb:3MNN|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4LD9|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:4XZQ|rcsb pdb:4YS3|rcsb pdb:4Z66|rcsb pdb:4ZUX|rcsb pdb:5CP6|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5G2E|rcsb pdb:5HQ2|rcsb pdb:5MLU|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:6FQ8|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6KW5|rcsb pdb:6LTJ|rcsb pdb:6N1Z|rcsb pdb:6NE3|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6NZO|rcsb pdb:6O96|rcsb pdb:6OM3|rcsb pdb:6PA7|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6PWX|rcsb pdb:6PX1|rcsb pdb:6PX3|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6FTX|rcsb pdb:6G0L|rcsb pdb:6I84|rcsb pdb:6TDA|rcsb pdb:6TEM|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6W4L|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6Z6P|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7CRO|rcsb pdb:7CRP|rcsb pdb:7CRQ|rcsb pdb:7CRR|rcsb pdb:7K6P|rcsb pdb:7K6Q|rcsb pdb:6WZ5	refseq:NP_001086753.1|dip:DIP-38577N|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4KHA|rcsb pdb:4LD9|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6PWX|rcsb pdb:6PX1|rcsb pdb:6PX3|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6TEM|rcsb pdb:6UGM|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6W4L|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7AT8|rcsb pdb:7CRO|rcsb pdb:7CRP|rcsb pdb:7CRQ|rcsb pdb:6PA7|rcsb pdb:7CRR|rcsb pdb:7E8I|rcsb pdb:7K6P|rcsb pdb:7K6Q|rcsb pdb:4Z66|rcsb pdb:4ZUX|rcsb pdb:5CP6|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5G2E|rcsb pdb:5HQ2|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:6FQ8|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JYL|rcsb pdb:6K01|rcsb pdb:6K1P|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:4XZQ|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6LTJ|rcsb pdb:4YS3|rcsb pdb:6N1Z|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6NZO|rcsb pdb:6O96|rcsb pdb:6OM3|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000558(Histone H2B)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|rcsb pdb:1AOI|rcsb pdb:1F66|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1M18|rcsb pdb:1M19|rcsb pdb:1M1A|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:1ZBB	-	-	-	figure legend:Extended Data Fig 1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/11/16	2020/11/16	rogid:IstEQHlz7X72xddS8qj3PuOQ0H08355	rogid:+nkA0I7sW2isaEdOjTHa7+jcsDw8355	rigid:521aMcpJO1h1BhVuU2XTkBUDsQc	false	-	binding-associated region:5-126|mutation:33-33	2	2	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P06897	uniprotkb:P84233	intact:EBI-1251194|uniprotkb:Q3B8I8	intact:EBI-350041|uniprotkb:P02295|uniprotkb:P02297|uniprotkb:P16105|uniprotkb:P17269|uniprotkb:A4FVE2|uniprotkb:P17320	psi-mi:h2a1_xenla(display_long)	psi-mi:h32_xenla(display_long)	psi-mi:"MI:0071"(molecular sieving)	Xu et al. (2020)	imex:IM-28696|pubmed:32968275	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26447436|imex:IM-28696-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001089684.1|dip:DIP-39144N|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|rcsb pdb:1AOI|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1M18|rcsb pdb:1M19|rcsb pdb:1M1A|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:1ZBB|rcsb pdb:1ZLA|rcsb pdb:2FJ7|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3C1B|rcsb pdb:3C1C|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:3LJA|rcsb pdb:3MNN|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4LD9|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:4XZQ|rcsb pdb:4YS3|rcsb pdb:4Z66|rcsb pdb:4ZUX|rcsb pdb:5CP6|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5G2E|rcsb pdb:5HQ2|rcsb pdb:5MLU|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:6FQ8|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6KW5|rcsb pdb:6LTJ|rcsb pdb:6N1Z|rcsb pdb:6NE3|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6NZO|rcsb pdb:6O96|rcsb pdb:6OM3|rcsb pdb:6PA7|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6PWX|rcsb pdb:6PX1|rcsb pdb:6PX3|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6FTX|rcsb pdb:6G0L|rcsb pdb:6I84|rcsb pdb:6TDA|rcsb pdb:6TEM|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6W4L|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6Z6P|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7CRO|rcsb pdb:7CRP|rcsb pdb:7CRQ|rcsb pdb:7CRR|rcsb pdb:7K6P|rcsb pdb:7K6Q|rcsb pdb:6WZ5	refseq:NP_001091428.1|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5HQ2|rcsb pdb:5KGF|rcsb pdb:5MLU|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XBK|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6KW5|rcsb pdb:6NE3|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6O22|rcsb pdb:6O96|rcsb pdb:6OM3|rcsb pdb:6PA7|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6PWX|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6Z6P|rcsb pdb:7AT8|rcsb pdb:7K6P|rcsb pdb:7K6Q|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|rcsb pdb:1F66|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:1ZBB|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2HUE|rcsb pdb:2IO5|rcsb pdb:2L11|rcsb pdb:2L12|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3C1B|rcsb pdb:3C1C|rcsb pdb:3GV6|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:4ZUX|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:5BS7|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:5BSA|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:5CP6|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4EO5|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4LD9|rcsb pdb:4QEO|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:4XZQ|rcsb pdb:4YS3|rcsb pdb:4Z66|refseq:XP_018079657.1|refseq:XP_018096294.1|refseq:XP_018096295.1|refseq:XP_018096296.1|refseq:XP_018098036.1|refseq:XP_018118226.1|refseq:XP_018118227.1|dip:DIP-37430N	-	-	-	figure legend:Extended Data Fig 1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/11/16	2020/11/16	rogid:IstEQHlz7X72xddS8qj3PuOQ0H08355	rogid:2TuVqWkeAnhHR4nrl0GNyUj1N3o8355	rigid:521aMcpJO1h1BhVuU2XTkBUDsQc	false	-	-	2	2	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P06897	uniprotkb:P62799	intact:EBI-1251194|uniprotkb:Q3B8I8	intact:EBI-302085|uniprotkb:P02304|uniprotkb:P02305|uniprotkb:Q6AZG5	psi-mi:h2a1_xenla(display_long)	psi-mi:h4_xenla(display_long)	psi-mi:"MI:0071"(molecular sieving)	Xu et al. (2020)	imex:IM-28696|pubmed:32968275	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26447436|imex:IM-28696-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001089684.1|dip:DIP-39144N|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|rcsb pdb:1AOI|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1M18|rcsb pdb:1M19|rcsb pdb:1M1A|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:1ZBB|rcsb pdb:1ZLA|rcsb pdb:2FJ7|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3C1B|rcsb pdb:3C1C|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:3LJA|rcsb pdb:3MNN|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4LD9|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:4XZQ|rcsb pdb:4YS3|rcsb pdb:4Z66|rcsb pdb:4ZUX|rcsb pdb:5CP6|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5G2E|rcsb pdb:5HQ2|rcsb pdb:5MLU|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:6FQ8|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6KW5|rcsb pdb:6LTJ|rcsb pdb:6N1Z|rcsb pdb:6NE3|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6NZO|rcsb pdb:6O96|rcsb pdb:6OM3|rcsb pdb:6PA7|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6PWX|rcsb pdb:6PX1|rcsb pdb:6PX3|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6FTX|rcsb pdb:6G0L|rcsb pdb:6I84|rcsb pdb:6TDA|rcsb pdb:6TEM|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6W4L|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6Z6P|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7CRO|rcsb pdb:7CRP|rcsb pdb:7CRQ|rcsb pdb:7CRR|rcsb pdb:7K6P|rcsb pdb:7K6Q|rcsb pdb:6WZ5	go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR001951(Histone H4)|interpro:IPR004823("TATA box binding protein associated factor (TAF)")|interpro:IPR009072(Histone-fold)|interpro:IPR019809|interpro:IPR035425|rcsb pdb:1AOI|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1M18|rcsb pdb:1M19|rcsb pdb:1M1A|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:5BSA|rcsb pdb:5CP6|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5HQ2|rcsb pdb:5KGF|rcsb pdb:5MLU|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:1ZBB|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2HUE|rcsb pdb:2IO5|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3C1B|rcsb pdb:3C1C|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4EO5|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4LD9|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:4XZQ|rcsb pdb:4YS3|rcsb pdb:4Z66|rcsb pdb:4ZBJ|rcsb pdb:4ZUX|rcsb pdb:5BS7|rcsb pdb:6FQ8|rcsb pdb:6PWW|rcsb pdb:6FTX|rcsb pdb:6G0L|rcsb pdb:6GYT|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JYL|rcsb pdb:6K1P|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6KW5|rcsb pdb:6LTJ|rcsb pdb:6NE3|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6NZO|rcsb pdb:6O22|rcsb pdb:6O96|rcsb pdb:6OM3|rcsb pdb:6PA7|rcsb pdb:6PWV|refseq:NP_001087926.1|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7AT8|rcsb pdb:7CRO|rcsb pdb:7CRP|rcsb pdb:7CRQ|rcsb pdb:7CRR|rcsb pdb:7E8I|rcsb pdb:7K6P|rcsb pdb:7K6Q|rcsb pdb:7KTQ|rcsb pdb:6PWX|rcsb pdb:6PX1|rcsb pdb:6PX3|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6TEM|rcsb pdb:6UGM|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6VZ4|rcsb pdb:6W5I|dip:DIP-37429N|refseq:XP_018095104.1|refseq:XP_018095605.1|refseq:XP_018095606.1|refseq:XP_018096302.1|refseq:XP_018097458.1|refseq:XP_018098137.1|refseq:XP_018118237.1|refseq:XP_018120359.1|refseq:XP_018120360.1	-	-	-	figure legend:Extended Data Fig 1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/11/16	2020/11/16	rogid:IstEQHlz7X72xddS8qj3PuOQ0H08355	rogid:LZSfhrpw0PcDREEoJ1UMkBvnUfA8355	rigid:521aMcpJO1h1BhVuU2XTkBUDsQc	false	-	-	2	2	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:Q9UBC3	uniprotkb:Q9Y6K1	intact:EBI-80125|uniprotkb:Q9UBD4|uniprotkb:Q9UJQ5|uniprotkb:Q9UKA6|uniprotkb:Q9UNE5|uniprotkb:Q9Y5R9|uniprotkb:Q9Y5S0|intact:EBI-28970262|ensembl:ENSP00000328547|uniprotkb:A2A2E2|uniprotkb:E1P5M6|uniprotkb:E1P5M7|uniprotkb:B4DSM8|uniprotkb:B4DSU1|uniprotkb:E7EN63|uniprotkb:E9PBF2	intact:EBI-923653|uniprotkb:Q8WXU9|uniprotkb:Q86XF5|uniprotkb:Q8IZV0|uniprotkb:Q86TE8|uniprotkb:E9PEB8|ensembl:ENSP00000264709|ensembl:ENSP00000324375	psi-mi:dnm3b_human(display_long)|uniprotkb:DNMT3B(gene name)|psi-mi:DNMT3B(display_short)|uniprotkb:DNA methyltransferase HsaIIIB(gene name synonym)	psi-mi:dnm3a_human(display_long)|uniprotkb:DNMT3A(gene name)|psi-mi:DNMT3A(display_short)|uniprotkb:DNA methyltransferase HsaIIIA(gene name synonym)|uniprotkb:Cysteine methyltransferase DNMT3A(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Xu et al. (2020)	imex:IM-28696|pubmed:32968275	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26447448|imex:IM-28696-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000088305(gene)|ensembl:ENST00000328111(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0009008"(DNA-methyltransferase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0031000"(response to caffeine)|go:"GO:0032355"(response to estradiol)|go:"GO:0033189"(response to vitamin A)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0071455"(cellular response to hyperoxia)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR000313(PWWP)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR018117|interpro:IPR025766|interpro:IPR029063|interpro:IPR030488|interpro:IPR040552|mint:Q9UBC3|rcsb pdb:3FLG|rcsb pdb:3QKJ|rcsb pdb:5CIU|rcsb pdb:5NR3|rcsb pdb:5NRR|rcsb pdb:5NRV|rcsb pdb:5NV0|rcsb pdb:5NV2|rcsb pdb:5NV7|rcsb pdb:5NVO|rcsb pdb:6KDA|rcsb pdb:6KDB|rcsb pdb:6KDL|rcsb pdb:6KDP|rcsb pdb:6KDT|rcsb pdb:6PA7|rcsb pdb:6R3E|rcsb pdb:6U8P|rcsb pdb:6U8V|rcsb pdb:6U8W|rcsb pdb:6U8X|rcsb pdb:5NRS|rcsb pdb:6U90|rcsb pdb:6U91|reactome:R-HSA-212300|reactome:R-HSA-427413|reactome:R-HSA-4655427|reactome:R-HSA-5334118|reactome:R-HSA-9710421|ensembl:ENST00000353855|ensembl:ENSP00000313397|ensembl:ENST00000443239|ensembl:ENSP00000403169|ensembl:ENST00000456297|ensembl:ENSP00000412305|ensembl:ENST00000201963|ensembl:ENSP00000201963|ensembl:ENSP00000328547|ensembl:ENST00000348286|ensembl:ENSP00000337764|refseq:NP_001193984.1|refseq:NP_001193985.1|refseq:NP_008823.1|refseq:NP_787044.1|refseq:NP_787045.1|refseq:NP_787046.1|dip:DIP-30000N	refseq:NP_001307821.1|refseq:NP_072046.2|refseq:NP_783328.1|refseq:NP_783329.1|refseq:XP_016859015.1|refseq:XP_016859016.1|refseq:XP_011530969.1|refseq:NP_001307822.1|refseq:NP_715640.2|refseq:XP_005264232.1|dip:DIP-38004N|refseq:XP_005264234.1|ensembl:ENSG00000119772(gene)|ensembl:ENST00000264709(transcript)|ensembl:ENST00000321117(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010288"(response to lead ion)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030182"(neuron differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0033189"(response to vitamin A)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|interpro:IPR000313(PWWP)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR018117|interpro:IPR025766|interpro:IPR029063|interpro:IPR030487|interpro:IPR040552|interpro:IPR044108|mint:Q9Y6K1|rcsb pdb:2QRV|rcsb pdb:3A1A|rcsb pdb:3A1B|rcsb pdb:3LLR|rcsb pdb:3SVM|rcsb pdb:4QBQ|rcsb pdb:4QBR|rcsb pdb:4QBS|rcsb pdb:4U7P|rcsb pdb:4U7T|rcsb pdb:5YX2|rcsb pdb:6BRR|rcsb pdb:6F57|rcsb pdb:6PA7|rcsb pdb:6W89|rcsb pdb:6W8B|rcsb pdb:6W8D|rcsb pdb:6W8J|reactome:R-HSA-212300|reactome:R-HSA-3214858|reactome:R-HSA-4655427|reactome:R-HSA-5334118|reactome:R-HSA-9710421	-	-	-	figure legend:Extended Data Fig 1d, 1e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/11/16	2020/11/16	rogid:xxbu/yvuQ1KnhVE/FdTh9CyA6jw9606	rogid:rnq1Yv4tlQ1t9JXS3CfMmTlcPKE9606	rigid:U9PjYzKnYRTOOjILBvVQ2N37oVI	false	-	-	2	2	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:Q9UBC3	uniprotkb:Q9Y6K1	intact:EBI-80125|uniprotkb:Q9UBD4|uniprotkb:Q9UJQ5|uniprotkb:Q9UKA6|uniprotkb:Q9UNE5|uniprotkb:Q9Y5R9|uniprotkb:Q9Y5S0|intact:EBI-28970262|ensembl:ENSP00000328547|uniprotkb:A2A2E2|uniprotkb:E1P5M6|uniprotkb:E1P5M7|uniprotkb:B4DSM8|uniprotkb:B4DSU1|uniprotkb:E7EN63|uniprotkb:E9PBF2	intact:EBI-923653|uniprotkb:Q8WXU9|uniprotkb:Q86XF5|uniprotkb:Q8IZV0|uniprotkb:Q86TE8|uniprotkb:E9PEB8|ensembl:ENSP00000264709|ensembl:ENSP00000324375	psi-mi:dnm3b_human(display_long)|uniprotkb:DNMT3B(gene name)|psi-mi:DNMT3B(display_short)|uniprotkb:DNA methyltransferase HsaIIIB(gene name synonym)	psi-mi:dnm3a_human(display_long)|uniprotkb:DNMT3A(gene name)|psi-mi:DNMT3A(display_short)|uniprotkb:DNA methyltransferase HsaIIIA(gene name synonym)|uniprotkb:Cysteine methyltransferase DNMT3A(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Xu et al. (2020)	imex:IM-28696|pubmed:32968275	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26447460|imex:IM-28696-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000088305(gene)|ensembl:ENST00000328111(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0009008"(DNA-methyltransferase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0031000"(response to caffeine)|go:"GO:0032355"(response to estradiol)|go:"GO:0033189"(response to vitamin A)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0071455"(cellular response to hyperoxia)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR000313(PWWP)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR018117|interpro:IPR025766|interpro:IPR029063|interpro:IPR030488|interpro:IPR040552|mint:Q9UBC3|rcsb pdb:3FLG|rcsb pdb:3QKJ|rcsb pdb:5CIU|rcsb pdb:5NR3|rcsb pdb:5NRR|rcsb pdb:5NRV|rcsb pdb:5NV0|rcsb pdb:5NV2|rcsb pdb:5NV7|rcsb pdb:5NVO|rcsb pdb:6KDA|rcsb pdb:6KDB|rcsb pdb:6KDL|rcsb pdb:6KDP|rcsb pdb:6KDT|rcsb pdb:6PA7|rcsb pdb:6R3E|rcsb pdb:6U8P|rcsb pdb:6U8V|rcsb pdb:6U8W|rcsb pdb:6U8X|rcsb pdb:5NRS|rcsb pdb:6U90|rcsb pdb:6U91|reactome:R-HSA-212300|reactome:R-HSA-427413|reactome:R-HSA-4655427|reactome:R-HSA-5334118|reactome:R-HSA-9710421|ensembl:ENST00000353855|ensembl:ENSP00000313397|ensembl:ENST00000443239|ensembl:ENSP00000403169|ensembl:ENST00000456297|ensembl:ENSP00000412305|ensembl:ENST00000201963|ensembl:ENSP00000201963|ensembl:ENSP00000328547|ensembl:ENST00000348286|ensembl:ENSP00000337764|refseq:NP_001193984.1|refseq:NP_001193985.1|refseq:NP_008823.1|refseq:NP_787044.1|refseq:NP_787045.1|refseq:NP_787046.1|dip:DIP-30000N	refseq:NP_001307821.1|refseq:NP_072046.2|refseq:NP_783328.1|refseq:NP_783329.1|refseq:XP_016859015.1|refseq:XP_016859016.1|refseq:XP_011530969.1|refseq:NP_001307822.1|refseq:NP_715640.2|refseq:XP_005264232.1|dip:DIP-38004N|refseq:XP_005264234.1|ensembl:ENSG00000119772(gene)|ensembl:ENST00000264709(transcript)|ensembl:ENST00000321117(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010288"(response to lead ion)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030182"(neuron differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0033189"(response to vitamin A)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|interpro:IPR000313(PWWP)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR018117|interpro:IPR025766|interpro:IPR029063|interpro:IPR030487|interpro:IPR040552|interpro:IPR044108|mint:Q9Y6K1|rcsb pdb:2QRV|rcsb pdb:3A1A|rcsb pdb:3A1B|rcsb pdb:3LLR|rcsb pdb:3SVM|rcsb pdb:4QBQ|rcsb pdb:4QBR|rcsb pdb:4QBS|rcsb pdb:4U7P|rcsb pdb:4U7T|rcsb pdb:5YX2|rcsb pdb:6BRR|rcsb pdb:6F57|rcsb pdb:6PA7|rcsb pdb:6W89|rcsb pdb:6W8B|rcsb pdb:6W8D|rcsb pdb:6W8J|reactome:R-HSA-212300|reactome:R-HSA-3214858|reactome:R-HSA-4655427|reactome:R-HSA-5334118|reactome:R-HSA-9710421	-	-	-	figure legend:Extended Data Fig 1d, 1e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/11/16	2020/11/16	rogid:xxbu/yvuQ1KnhVE/FdTh9CyA6jw9606	rogid:rnq1Yv4tlQ1t9JXS3CfMmTlcPKE9606	rigid:U9PjYzKnYRTOOjILBvVQ2N37oVI	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)