#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P0DTD1-PRO_0000449623 intact:EBI-25612655 intact:EBI-25475864 - psi-mi:p0dtd1-pro_0000449623(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:dabcyl-ktsavlqsgfrkme-edans(display_short)|psi-mi:EBI-25612655(display_long) psi-mi:"MI:0435"(protease assay) Jang et al. (2019) pubmed:32963564|imex:IM-28397 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0570"(protein cleavage) psi-mi:"MI:0469"(IntAct) intact:EBI-26363315|imex:IM-28397-1 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0327"(peptide) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) pubmed:18583140(see-also) go:"GO:0004197"(cysteine-type endopeptidase activity) chain-seq-start:3264|chain-seq-end:3569 - figure legend:Figure 2B, 3-7.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/09/24 2020/10/02 rogid:9u1TJXDTORfCyqj2bv2TlDMZ65c2697049 rogid:5paWG8TKpS+Vdd4uWaMMBd0QUBk-2 rigid:AjyLX86/Ie8uYIiN31Zn33cnUmk false his tag:?-? - - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) chebi:"CHEBI:4806" intact:EBI-25612655 intact:EBI-10824768 - psi-mi:"(-)-epigallocatechin 3-gallate"(display_short)|psi-mi:"CHEBI:4806"(display_long)|intact:"(-)-epigallocatechin-3-O-gallate"(synonym)|intact:"[(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate"(synonym)|intact:EGCG(synonym)|intact:Epigallocatechin 3-gallate(synonym)|intact:"(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate"(iupac name) psi-mi:dabcyl-ktsavlqsgfrkme-edans(display_short)|psi-mi:EBI-25612655(display_long) psi-mi:"MI:0435"(protease assay) Jang et al. (2019) pubmed:32963564|imex:IM-28397 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0570"(protein cleavage) psi-mi:"MI:0469"(IntAct) intact:EBI-26363330|imex:IM-28397-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0327"(peptide) - pubmed:18583140(see-also) go:"GO:0004197"(cysteine-type endopeptidase activity) - - figure legend:Figure 3,5,6|inhibition:IC50 for EGCG of 7.58 ug/ml|comment:auto-oxidation products of EGCG reduce the inhibition.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/09/24 2020/10/02 - rogid:5paWG8TKpS+Vdd4uWaMMBd0QUBk-2 - false - - - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) chebi:"CHEBI:4806" uniprotkb:P0DTD1-PRO_0000449623 intact:EBI-10824768 intact:EBI-25475864 psi-mi:"(-)-epigallocatechin 3-gallate"(display_short)|psi-mi:"CHEBI:4806"(display_long)|intact:"(-)-epigallocatechin-3-O-gallate"(synonym)|intact:"[(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate"(synonym)|intact:EGCG(synonym)|intact:Epigallocatechin 3-gallate(synonym)|intact:"(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate"(iupac name) psi-mi:p0dtd1-pro_0000449623(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0435"(protease assay) Jang et al. (2019) pubmed:32963564|imex:IM-28397 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0570"(protein cleavage) psi-mi:"MI:0469"(IntAct) intact:EBI-26363330|imex:IM-28397-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) go:"GO:0004197"(cysteine-type endopeptidase activity) - chain-seq-start:3264|chain-seq-end:3569 figure legend:Figure 3,5,6|inhibition:IC50 for EGCG of 7.58 ug/ml|comment:auto-oxidation products of EGCG reduce the inhibition.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/09/24 2020/10/02 - rogid:9u1TJXDTORfCyqj2bv2TlDMZ65c2697049 - false - his tag:?-? - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) intact:EBI-25612655 uniprotkb:P0DTD1-PRO_0000449623 - intact:EBI-25475864 psi-mi:dabcyl-ktsavlqsgfrkme-edans(display_short)|psi-mi:EBI-25612655(display_long) psi-mi:p0dtd1-pro_0000449623(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0435"(protease assay) Jang et al. (2019) pubmed:32963564|imex:IM-28397 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0570"(protein cleavage) psi-mi:"MI:0469"(IntAct) intact:EBI-26363339|imex:IM-28397-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) pubmed:18583140(see-also) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) go:"GO:0004197"(cysteine-type endopeptidase activity) - chain-seq-start:3264|chain-seq-end:3569 figure legend:Figure 4,5|inhibition:IC50 for EGCG of 8.44 ug/ml|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/09/24 2020/10/02 rogid:5paWG8TKpS+Vdd4uWaMMBd0QUBk-2 rogid:9u1TJXDTORfCyqj2bv2TlDMZ65c2697049 - false - his tag:?-? - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) chebi:"CHEBI:136609" intact:EBI-25612655 intact:EBI-26363348 - psi-mi:theaflavin(display_short)|psi-mi:"CHEBI:136609"(display_long)|intact:"(-)-theaflavin"(synonym)|intact:"1,8-bis((2R,3R)-3,5,7-trihydroxy-2H-1-benzopyran-2-yl)-3,4,6-trihydroxy-5H-benzocyclohepten-5-one"(synonym)|intact:"1,8-bis(3-alpha,5,7-trihydroxy-2-alpha-chromanyl)-5H-benzocyclohepten-5-one"(synonym)|intact:"3,4,5-trihydroxy-1,8-bis[(2R,3R)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-2-yl]-6H-benzo[7]annulen-6-one"(synonym)|intact:theaflavine(synonym)|intact:"3,4,5-trihydroxy-1,8-bis[(2R,3R)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-2-yl]-6H-benzocyclohepten-6-one"(iupac name) psi-mi:dabcyl-ktsavlqsgfrkme-edans(display_short)|psi-mi:EBI-25612655(display_long) psi-mi:"MI:0435"(protease assay) Jang et al. (2019) pubmed:32963564|imex:IM-28397 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0570"(protein cleavage) psi-mi:"MI:0469"(IntAct) intact:EBI-26363339|imex:IM-28397-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0327"(peptide) - pubmed:18583140(see-also) go:"GO:0004197"(cysteine-type endopeptidase activity) - - figure legend:Figure 4,5|inhibition:IC50 for EGCG of 8.44 ug/ml|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/09/24 2020/10/02 - rogid:5paWG8TKpS+Vdd4uWaMMBd0QUBk-2 - false - - - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) chebi:"CHEBI:4806" intact:EBI-25612655 intact:EBI-10824768 - psi-mi:"(-)-epigallocatechin 3-gallate"(display_short)|psi-mi:"CHEBI:4806"(display_long)|intact:"(-)-epigallocatechin-3-O-gallate"(synonym)|intact:"[(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate"(synonym)|intact:EGCG(synonym)|intact:Epigallocatechin 3-gallate(synonym)|intact:"(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate"(iupac name) psi-mi:dabcyl-ktsavlqsgfrkme-edans(display_short)|psi-mi:EBI-25612655(display_long) psi-mi:"MI:0435"(protease assay) Jang et al. (2019) pubmed:32963564|imex:IM-28397 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0570"(protein cleavage) psi-mi:"MI:0469"(IntAct) intact:EBI-26363357|imex:IM-28397-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0327"(peptide) - pubmed:18583140(see-also) go:"GO:0004197"(cysteine-type endopeptidase activity) - - figure legend:Figure 5|inhibition:"The calculated CDI (coefficient of drug interaction) for EGCG and theaflavin = 0.93, indicating that EGCG and theaflavin had an additive rather than a synergistic effect."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/09/24 2020/10/02 - rogid:5paWG8TKpS+Vdd4uWaMMBd0QUBk-2 - false - - - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) chebi:"CHEBI:4806" uniprotkb:P0DTD1-PRO_0000449623 intact:EBI-10824768 intact:EBI-25475864 psi-mi:"(-)-epigallocatechin 3-gallate"(display_short)|psi-mi:"CHEBI:4806"(display_long)|intact:"(-)-epigallocatechin-3-O-gallate"(synonym)|intact:"[(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate"(synonym)|intact:EGCG(synonym)|intact:Epigallocatechin 3-gallate(synonym)|intact:"(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate"(iupac name) psi-mi:p0dtd1-pro_0000449623(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0435"(protease assay) Jang et al. (2019) pubmed:32963564|imex:IM-28397 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0570"(protein cleavage) psi-mi:"MI:0469"(IntAct) intact:EBI-26363357|imex:IM-28397-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) go:"GO:0004197"(cysteine-type endopeptidase activity) - chain-seq-start:3264|chain-seq-end:3569 figure legend:Figure 5|inhibition:"The calculated CDI (coefficient of drug interaction) for EGCG and theaflavin = 0.93, indicating that EGCG and theaflavin had an additive rather than a synergistic effect."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/09/24 2020/10/02 - rogid:9u1TJXDTORfCyqj2bv2TlDMZ65c2697049 - false - his tag:?-? - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) chebi:"CHEBI:4806" chebi:"CHEBI:136609" intact:EBI-10824768 intact:EBI-26363348 psi-mi:"(-)-epigallocatechin 3-gallate"(display_short)|psi-mi:"CHEBI:4806"(display_long)|intact:"(-)-epigallocatechin-3-O-gallate"(synonym)|intact:"[(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate"(synonym)|intact:EGCG(synonym)|intact:Epigallocatechin 3-gallate(synonym)|intact:"(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate"(iupac name) psi-mi:theaflavin(display_short)|psi-mi:"CHEBI:136609"(display_long)|intact:"(-)-theaflavin"(synonym)|intact:"1,8-bis((2R,3R)-3,5,7-trihydroxy-2H-1-benzopyran-2-yl)-3,4,6-trihydroxy-5H-benzocyclohepten-5-one"(synonym)|intact:"1,8-bis(3-alpha,5,7-trihydroxy-2-alpha-chromanyl)-5H-benzocyclohepten-5-one"(synonym)|intact:"3,4,5-trihydroxy-1,8-bis[(2R,3R)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-2-yl]-6H-benzo[7]annulen-6-one"(synonym)|intact:theaflavine(synonym)|intact:"3,4,5-trihydroxy-1,8-bis[(2R,3R)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-2-yl]-6H-benzocyclohepten-6-one"(iupac name) psi-mi:"MI:0435"(protease assay) Jang et al. (2019) pubmed:32963564|imex:IM-28397 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0570"(protein cleavage) psi-mi:"MI:0469"(IntAct) intact:EBI-26363357|imex:IM-28397-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0328"(small molecule) - - go:"GO:0004197"(cysteine-type endopeptidase activity) - - figure legend:Figure 5|inhibition:"The calculated CDI (coefficient of drug interaction) for EGCG and theaflavin = 0.93, indicating that EGCG and theaflavin had an additive rather than a synergistic effect."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/09/24 2020/10/02 - - - false - - - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence)