#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B chebi:"CHEBI:16960" uniprotkb:P0DTC1-PRO_0000449637 intact:EBI-25618313|chebi:"CHEBI:40752"|chebi:"CHEBI:13231"|chebi:"CHEBI:2351"|chebi:"CHEBI:20850"|chebi:"CHEBI:32889" intact:EBI-26361005 psi-mi:adp-d-ribose(display_short)|psi-mi:"CHEBI:16960"(display_long)|intact:"(Rib5)ppA"(synonym)|intact:"5-(adenosine 5'-pyrophosphoryl)-D-ribose"(synonym)|intact:A5'pp5Rib(synonym)|intact:"adenosine 5'-(trihydrogen diphosphate), P'-5-ester with D-ribose"(synonym)|intact:adenosine 5'-diphosphoribose(synonym)|intact:adenosine 5'-pyrophosphate, 5'-5-ester with D-ribofuranose(synonym)|intact:adenosine diphosphate ribose(synonym)|intact:Adenosine diphosphate ribose(synonym)|intact:AdoPPRib(synonym)|intact:ADP ribose(synonym)|intact:ADP-D-ribose(synonym)|intact:ADP-Rib(synonym)|intact:ADP-riboses(synonym)|intact:ADPribose(synonym)|intact:"D-ribofuranose, 5-5'-ester with adenosine 5'-(trihydrogen pyrophosphate)"(synonym)|intact:ribose adenosinediphosphate(synonym)|intact:"adenosine 5'-[3-(D-ribofuranos-5-O-yl) dihydrogen diphosphate]"(iupac name) psi-mi:p0dtc1-pro_0000449637(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Lin et al. (2020) pubmed:32946224|imex:IM-28383 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26360436|pdbe:7C33|imex:IM-28383-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - intact:EBI-25496252(chain-parent) - - chain-seq-start:819|chain-seq-end:2763 figure legend:Table 2|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/09/28 2020/12/15 - rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049 - false - sufficient binding region:207-377 4 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:16960" uniprotkb:P0DTC1-PRO_0000449637 intact:EBI-25618313|chebi:"CHEBI:40752"|chebi:"CHEBI:13231"|chebi:"CHEBI:2351"|chebi:"CHEBI:20850"|chebi:"CHEBI:32889" intact:EBI-26361005 psi-mi:adp-d-ribose(display_short)|psi-mi:"CHEBI:16960"(display_long)|intact:"(Rib5)ppA"(synonym)|intact:"5-(adenosine 5'-pyrophosphoryl)-D-ribose"(synonym)|intact:A5'pp5Rib(synonym)|intact:"adenosine 5'-(trihydrogen diphosphate), P'-5-ester with D-ribose"(synonym)|intact:adenosine 5'-diphosphoribose(synonym)|intact:adenosine 5'-pyrophosphate, 5'-5-ester with D-ribofuranose(synonym)|intact:adenosine diphosphate ribose(synonym)|intact:Adenosine diphosphate ribose(synonym)|intact:AdoPPRib(synonym)|intact:ADP ribose(synonym)|intact:ADP-D-ribose(synonym)|intact:ADP-Rib(synonym)|intact:ADP-riboses(synonym)|intact:ADPribose(synonym)|intact:"D-ribofuranose, 5-5'-ester with adenosine 5'-(trihydrogen pyrophosphate)"(synonym)|intact:ribose adenosinediphosphate(synonym)|intact:"adenosine 5'-[3-(D-ribofuranos-5-O-yl) dihydrogen diphosphate]"(iupac name) psi-mi:p0dtc1-pro_0000449637(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Lin et al. (2020) pubmed:32946224|imex:IM-28383 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26565142|wwpdb:7cz4|imex:IM-28383-24 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - intact:EBI-25496252(chain-parent) - - chain-seq-start:819|chain-seq-end:2763 figure legend:Table 2|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/09/28 2020/12/15 - rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049 - false - sufficient binding region:207-377 2 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:16960" uniprotkb:P0DTC1-PRO_0000449637 intact:EBI-25618313|chebi:"CHEBI:40752"|chebi:"CHEBI:13231"|chebi:"CHEBI:2351"|chebi:"CHEBI:20850"|chebi:"CHEBI:32889" intact:EBI-26361005 psi-mi:adp-d-ribose(display_short)|psi-mi:"CHEBI:16960"(display_long)|intact:"(Rib5)ppA"(synonym)|intact:"5-(adenosine 5'-pyrophosphoryl)-D-ribose"(synonym)|intact:A5'pp5Rib(synonym)|intact:"adenosine 5'-(trihydrogen diphosphate), P'-5-ester with D-ribose"(synonym)|intact:adenosine 5'-diphosphoribose(synonym)|intact:adenosine 5'-pyrophosphate, 5'-5-ester with D-ribofuranose(synonym)|intact:adenosine diphosphate ribose(synonym)|intact:Adenosine diphosphate ribose(synonym)|intact:AdoPPRib(synonym)|intact:ADP ribose(synonym)|intact:ADP-D-ribose(synonym)|intact:ADP-Rib(synonym)|intact:ADP-riboses(synonym)|intact:ADPribose(synonym)|intact:"D-ribofuranose, 5-5'-ester with adenosine 5'-(trihydrogen pyrophosphate)"(synonym)|intact:ribose adenosinediphosphate(synonym)|intact:"adenosine 5'-[3-(D-ribofuranos-5-O-yl) dihydrogen diphosphate]"(iupac name) psi-mi:p0dtc1-pro_0000449637(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Lin et al. (2020) pubmed:32946224|imex:IM-28383 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26360595|imex:IM-28383-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - intact:EBI-25496252(chain-parent) - - chain-seq-start:819|chain-seq-end:2763 figure legend:Table 1, Fig. 3a, Supp. 4B.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:17.18x10^-6 ~6.03(molar) 2020/09/28 2020/12/15 - rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049 - false - sufficient binding region:207-377|mutation increasing interaction strength:228-229,360-360 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:16960" uniprotkb:P0DTC1-PRO_0000449637 intact:EBI-25618313|chebi:"CHEBI:40752"|chebi:"CHEBI:13231"|chebi:"CHEBI:2351"|chebi:"CHEBI:20850"|chebi:"CHEBI:32889" intact:EBI-26361005 psi-mi:adp-d-ribose(display_short)|psi-mi:"CHEBI:16960"(display_long)|intact:"(Rib5)ppA"(synonym)|intact:"5-(adenosine 5'-pyrophosphoryl)-D-ribose"(synonym)|intact:A5'pp5Rib(synonym)|intact:"adenosine 5'-(trihydrogen diphosphate), P'-5-ester with D-ribose"(synonym)|intact:adenosine 5'-diphosphoribose(synonym)|intact:adenosine 5'-pyrophosphate, 5'-5-ester with D-ribofuranose(synonym)|intact:adenosine diphosphate ribose(synonym)|intact:Adenosine diphosphate ribose(synonym)|intact:AdoPPRib(synonym)|intact:ADP ribose(synonym)|intact:ADP-D-ribose(synonym)|intact:ADP-Rib(synonym)|intact:ADP-riboses(synonym)|intact:ADPribose(synonym)|intact:"D-ribofuranose, 5-5'-ester with adenosine 5'-(trihydrogen pyrophosphate)"(synonym)|intact:ribose adenosinediphosphate(synonym)|intact:"adenosine 5'-[3-(D-ribofuranos-5-O-yl) dihydrogen diphosphate]"(iupac name) psi-mi:p0dtc1-pro_0000449637(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym) psi-mi:"MI:1235"(thermal shift binding) Lin et al. (2020) pubmed:32946224|imex:IM-28383 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26365244|imex:IM-28383-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - intact:EBI-25496252(chain-parent) - - chain-seq-start:819|chain-seq-end:2763 figure legend:Table 1, Fig. 3c|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:20.6x10^-6 ~7.7(molar) 2020/09/28 2020/10/06 - rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049 - false - sufficient binding region:207-377 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:16960" uniprotkb:P0DTC1-PRO_0000449637 intact:EBI-25618313|chebi:"CHEBI:40752"|chebi:"CHEBI:13231"|chebi:"CHEBI:2351"|chebi:"CHEBI:20850"|chebi:"CHEBI:32889" intact:EBI-26361005 psi-mi:adp-d-ribose(display_short)|psi-mi:"CHEBI:16960"(display_long)|intact:"(Rib5)ppA"(synonym)|intact:"5-(adenosine 5'-pyrophosphoryl)-D-ribose"(synonym)|intact:A5'pp5Rib(synonym)|intact:"adenosine 5'-(trihydrogen diphosphate), P'-5-ester with D-ribose"(synonym)|intact:adenosine 5'-diphosphoribose(synonym)|intact:adenosine 5'-pyrophosphate, 5'-5-ester with D-ribofuranose(synonym)|intact:adenosine diphosphate ribose(synonym)|intact:Adenosine diphosphate ribose(synonym)|intact:AdoPPRib(synonym)|intact:ADP ribose(synonym)|intact:ADP-D-ribose(synonym)|intact:ADP-Rib(synonym)|intact:ADP-riboses(synonym)|intact:ADPribose(synonym)|intact:"D-ribofuranose, 5-5'-ester with adenosine 5'-(trihydrogen pyrophosphate)"(synonym)|intact:ribose adenosinediphosphate(synonym)|intact:"adenosine 5'-[3-(D-ribofuranos-5-O-yl) dihydrogen diphosphate]"(iupac name) psi-mi:p0dtc1-pro_0000449637(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym) psi-mi:"MI:1235"(thermal shift binding) Lin et al. (2020) pubmed:32946224|imex:IM-28383 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26365222|imex:IM-28383-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - intact:EBI-25496252(chain-parent) - - chain-seq-start:819|chain-seq-end:2763 figure legend:Fig. 3d|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/09/28 2020/10/06 - rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049 - false - sufficient binding region:207-377 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:16761" uniprotkb:P0DTC1-PRO_0000449637 intact:EBI-1188073 intact:EBI-26361005 psi-mi:adp(display_short)|psi-mi:"CHEBI:16761"(display_long) psi-mi:p0dtc1-pro_0000449637(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym) psi-mi:"MI:1235"(thermal shift binding) Lin et al. (2020) pubmed:32946224|imex:IM-28383 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26365252|imex:IM-28383-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - intact:EBI-25496252(chain-parent) - - chain-seq-start:819|chain-seq-end:2763 figure legend:Fig. 3d|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/09/28 2020/10/06 - rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049 - false - sufficient binding region:207-377 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:16027" uniprotkb:P0DTC1-PRO_0000449637 intact:EBI-6868581|chebi:"CHEBI:13740"|chebi:"CHEBI:40510"|chebi:"CHEBI:22242"|chebi:"CHEBI:40726"|chebi:"CHEBI:40786"|chebi:"CHEBI:40826"|chebi:"CHEBI:47222"|chebi:"CHEBI:12056"|chebi:"CHEBI:2356"|chebi:"CHEBI:13736"|chebi:"CHEBI:13234"|chebi:"CHEBI:13235"|chebi:"CHEBI:22245" intact:EBI-26361005 psi-mi:amp(display_short)|psi-mi:"CHEBI:16027"(display_long)|intact:5'-Adenosine monophosphate(synonym)|intact:5'-Adenylic acid(synonym)|intact:5'-AMP(synonym)|intact:5'-O-phosphonoadenosine(synonym)|intact:"adenosine 5'-(dihydrogen phosphate)"(synonym)|intact:Adenosine 5'-monophosphate(synonym)|intact:Adenosine 5'-phosphate(synonym)|intact:ADENOSINE MONOPHOSPHATE(synonym)|intact:adenosine phosphate(synonym)|intact:Adenosine-5'-monophosphoric acid(synonym)|intact:adenosine-5'P(synonym)|intact:adenosini phosphas(synonym)|intact:Adenylate(synonym)|intact:Adenylic acid(synonym)|intact:Ado5'P(synonym)|intact:AMP(synonym)|intact:fosfato de adenosina(synonym)|intact:pA(synonym)|intact:PAdo(synonym)|intact:phosphate d'adenosine(synonym)|intact:5'-adenylic acid(iupac name) psi-mi:p0dtc1-pro_0000449637(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym) psi-mi:"MI:1235"(thermal shift binding) Lin et al. (2020) pubmed:32946224|imex:IM-28383 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26365258|imex:IM-28383-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - intact:EBI-25496252(chain-parent) - - chain-seq-start:819|chain-seq-end:2763 figure legend:Fig. 3d|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/09/28 2020/10/06 - rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049 - false - sufficient binding region:207-377 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:16960" uniprotkb:P0DTC1-PRO_0000449637 intact:EBI-25618313|chebi:"CHEBI:40752"|chebi:"CHEBI:13231"|chebi:"CHEBI:2351"|chebi:"CHEBI:20850"|chebi:"CHEBI:32889" intact:EBI-26361005 psi-mi:adp-d-ribose(display_short)|psi-mi:"CHEBI:16960"(display_long)|intact:"(Rib5)ppA"(synonym)|intact:"5-(adenosine 5'-pyrophosphoryl)-D-ribose"(synonym)|intact:A5'pp5Rib(synonym)|intact:"adenosine 5'-(trihydrogen diphosphate), P'-5-ester with D-ribose"(synonym)|intact:adenosine 5'-diphosphoribose(synonym)|intact:adenosine 5'-pyrophosphate, 5'-5-ester with D-ribofuranose(synonym)|intact:adenosine diphosphate ribose(synonym)|intact:Adenosine diphosphate ribose(synonym)|intact:AdoPPRib(synonym)|intact:ADP ribose(synonym)|intact:ADP-D-ribose(synonym)|intact:ADP-Rib(synonym)|intact:ADP-riboses(synonym)|intact:ADPribose(synonym)|intact:"D-ribofuranose, 5-5'-ester with adenosine 5'-(trihydrogen pyrophosphate)"(synonym)|intact:ribose adenosinediphosphate(synonym)|intact:"adenosine 5'-[3-(D-ribofuranos-5-O-yl) dihydrogen diphosphate]"(iupac name) psi-mi:p0dtc1-pro_0000449637(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym) psi-mi:"MI:1235"(thermal shift binding) Lin et al. (2020) pubmed:32946224|imex:IM-28383 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26365322|imex:IM-28383-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - intact:EBI-25496252(chain-parent) - - chain-seq-start:819|chain-seq-end:2763 figure legend:Fig. 2b|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/09/28 2020/10/07 - rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049 - false - sufficient binding region:207-377 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q53GL7 uniprotkb:P0DTC1-PRO_0000449637 intact:EBI-2857573|uniprotkb:Q8N2I0|uniprotkb:Q8WV05|uniprotkb:Q96CH7|uniprotkb:Q96K72|ensembl:ENSP00000325618 intact:EBI-26361005 psi-mi:par10_human(display_long)|uniprotkb:Poly [ADP-ribose] polymerase 10(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 10(gene name synonym)|uniprotkb:PARP10(gene name)|psi-mi:PARP10(display_short) psi-mi:p0dtc1-pro_0000449637(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym) psi-mi:"MI:1309"(de-ADP-ribosylation assay) Lin et al. (2020) pubmed:32946224|imex:IM-28383 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:1310"(de-ADP-ribosylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26365343|imex:IM-28383-13 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_116178.2|go:"GO:0034356"(NAD biosynthesis via nicotinamide riboside salvage pathway)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0140289"(protein mono-ADP-ribosylation)|go:"GO:1900045"(negative regulation of protein K63-linked ubiquitination)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034464|rcsb pdb:2DHX|rcsb pdb:3HKV|rcsb pdb:5LX6|rcsb pdb:6FXI|reactome:R-HSA-197264|reactome:R-HSA-9683610|reactome:R-HSA-9694631|ensembl:ENSG00000178685(gene)|ensembl:ENST00000313028(transcript)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010847"(regulation of chromatin assembly)|go:"GO:0019082"(viral protein processing)|go:"GO:0019985"(translesion synthesis)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity) intact:EBI-25496252(chain-parent) go:"GO:0051725"(protein de-ADP-ribosylation) - chain-seq-start:819|chain-seq-end:2763 figure legend:Fig. 4a-b|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/09/28 2020/10/07 rogid:WcJRnNPrEAYD6vk9c4ACoh5fX1U9606 rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049 rigid:U1zqkS/fHW6BtwofLc70Db/XUR0 false biotin tag:?-?|"monoadenosine diphosphoribosyl (ADP-ribosyl) modified residue":?-?|sufficient binding region:806..806-1025..1025(IPR012317) sufficient binding region:207-377 - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:Q53GL7 uniprotkb:P38218 intact:EBI-2857573|uniprotkb:Q8N2I0|uniprotkb:Q8WV05|uniprotkb:Q96CH7|uniprotkb:Q96K72|ensembl:ENSP00000325618 intact:EBI-26365382|ensemblfungi:YBR022W|uniprotkb:D6VQ24 psi-mi:par10_human(display_long)|uniprotkb:Poly [ADP-ribose] polymerase 10(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 10(gene name synonym)|uniprotkb:PARP10(gene name)|psi-mi:PARP10(display_short) psi-mi:poa1_yeast(display_long)|uniprotkb:POA1(gene name)|psi-mi:POA1(display_short)|uniprotkb:[Protein ADP-ribosylglutamate] hydrolase(gene name synonym)|uniprotkb:YBR0304(orf name)|uniprotkb:YBR022W(locus name) psi-mi:"MI:1309"(de-ADP-ribosylation assay) Lin et al. (2020) pubmed:32946224|imex:IM-28383 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:1310"(de-ADP-ribosylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26365354|imex:IM-28383-15 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_116178.2|go:"GO:0034356"(NAD biosynthesis via nicotinamide riboside salvage pathway)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0140289"(protein mono-ADP-ribosylation)|go:"GO:1900045"(negative regulation of protein K63-linked ubiquitination)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034464|rcsb pdb:2DHX|rcsb pdb:3HKV|rcsb pdb:5LX6|rcsb pdb:6FXI|reactome:R-HSA-197264|reactome:R-HSA-9683610|reactome:R-HSA-9694631|ensembl:ENSG00000178685(gene)|ensembl:ENST00000313028(transcript)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010847"(regulation of chromatin assembly)|go:"GO:0019082"(viral protein processing)|go:"GO:0019985"(translesion synthesis)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity) ensemblfungi:YBR022W(gene)|ensemblfungi:YBR022W_mRNA(transcript)|go:"GO:0006388"(tRNA splicing, via endonucleolytic cleavage and ligation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0047407"(ADP-ribosyl-[dinitrogen reductase] hydrolase activity)|go:"GO:0140291"(peptidyl-glutamate ADP-deribosylation)|sgd:S000000226|refseq:NP_009578.1|interpro:IPR002589(Appr-1-p processing)|interpro:IPR043472|rcsb pdb:6LFQ|rcsb pdb:6LFR|rcsb pdb:6LFS|rcsb pdb:6LFT|rcsb pdb:6LFU go:"GO:0051725"(protein de-ADP-ribosylation) - - figure legend:Fig. 4a-b|comment:Positive control|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/09/28 2020/10/14 rogid:WcJRnNPrEAYD6vk9c4ACoh5fX1U9606 rogid:MVdR+aVCpRvq5brhxZUX8AdwDsY559292 rigid:k+OmZcVMCnkcmTY7hRMl6qd1w7Q false sufficient binding region:806..806-1025..1025(IPR012317)|biotin tag:?-?|"monoadenosine diphosphoribosyl (ADP-ribosyl) modified residue":?-? sufficient binding region:1..1-177..177(IPR002589) - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) chebi:"CHEBI:15846" uniprotkb:Q53GL7 intact:EBI-4399035 intact:EBI-2857573|uniprotkb:Q8N2I0|uniprotkb:Q8WV05|uniprotkb:Q96CH7|uniprotkb:Q96K72|ensembl:ENSP00000325618 psi-mi:nad+(display_short)|psi-mi:"CHEBI:15846"(display_long) psi-mi:par10_human(display_long)|uniprotkb:Poly [ADP-ribose] polymerase 10(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 10(gene name synonym)|uniprotkb:PARP10(gene name)|psi-mi:PARP10(display_short) psi-mi:"MI:1005"(adp ribosylase assay) Lin et al. (2020) pubmed:32946224|imex:IM-28383 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0557"(adp ribosylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26365423|imex:IM-28383-17 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0898"(putative self) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:NP_116178.2|go:"GO:0034356"(NAD biosynthesis via nicotinamide riboside salvage pathway)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0140289"(protein mono-ADP-ribosylation)|go:"GO:1900045"(negative regulation of protein K63-linked ubiquitination)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034464|rcsb pdb:2DHX|rcsb pdb:3HKV|rcsb pdb:5LX6|rcsb pdb:6FXI|reactome:R-HSA-197264|reactome:R-HSA-9683610|reactome:R-HSA-9694631|ensembl:ENSG00000178685(gene)|ensembl:ENST00000313028(transcript)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010847"(regulation of chromatin assembly)|go:"GO:0019082"(viral protein processing)|go:"GO:0019985"(translesion synthesis)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity) go:"GO:0070213"(protein auto-ADP-ribosylation) - - figure legend:Fig. 4a|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/09/28 2020/10/14 - rogid:WcJRnNPrEAYD6vk9c4ACoh5fX1U9606 - false biotin tag:?-? sufficient binding region:806..806-1025..1025(IPR012317) - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) chebi:"CHEBI:8288" uniprotkb:P0DTC1-PRO_0000449637 intact:EBI-26367656 intact:EBI-26361005 psi-mi:"poly(adpribose)"(display_short)|psi-mi:"CHEBI:8288"(display_long)|intact:"Poly(ADPribose)"(synonym) psi-mi:p0dtc1-pro_0000449637(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym) psi-mi:"MI:0049"(filter binding) Lin et al. (2020) pubmed:32946224|imex:IM-28383 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26365621|imex:IM-28383-21 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - intact:EBI-25496252(chain-parent) - - chain-seq-start:819|chain-seq-end:2763 figure legend:Fig. 4c|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/09/28 2020/10/13 - rogid:edNmSGWH7aKPoOZtWjGjL1M0aK42697049 - false - sufficient binding region:207-377 - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) chebi:"CHEBI:8288" uniprotkb:Q86WJ1 intact:EBI-26367656 intact:EBI-2340020|intact:EBI-2857214|uniprotkb:Q53EZ3|uniprotkb:Q9NVV8|uniprotkb:Q86XH3|uniprotkb:Q5VXX7|uniprotkb:A5YM64|uniprotkb:Q6PK83|uniprotkb:Q96SP3|uniprotkb:Q9BVJ1|uniprotkb:Q6DD94|uniprotkb:Q96HF7|uniprotkb:B4DDE1|uniprotkb:B5MDZ7|ensembl:ENSP00000358262 psi-mi:"poly(adpribose)"(display_short)|psi-mi:"CHEBI:8288"(display_long)|intact:"Poly(ADPribose)"(synonym) psi-mi:chd1l_human(display_long)|uniprotkb:CHD1L(gene name)|psi-mi:CHD1L(display_short)|uniprotkb:ALC1(gene name synonym)|uniprotkb:Amplified in liver cancer protein 1(gene name synonym) psi-mi:"MI:0049"(filter binding) Lin et al. (2020) pubmed:32946224|imex:IM-28383 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26365632|imex:IM-28383-23 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:NP_001243267.1|refseq:NP_004275.4|dip:DIP-48933N|refseq:NP_001335382.1|refseq:NP_078844.2|refseq:NP_001243266.1|refseq:NP_001335385.1|refseq:NP_001335386.1|refseq:NP_001335387.1|refseq:NP_001335388.1|refseq:NP_001335389.1|refseq:NP_001335390.1|refseq:NP_001335391.1|refseq:NP_001335392.1|refseq:NP_001335393.1|refseq:NP_001335394.1|refseq:NP_001335395.1|ensembl:ENSG00000131778(gene)|ensembl:ENST00000369258(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0070615"|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR002589(Appr-1-p processing)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR031053|interpro:IPR038718|interpro:IPR043472|mint:Q86WJ1|rcsb pdb:6ZHX|rcsb pdb:6ZHY|reactome:R-HSA-5696395|reactome:R-HSA-5696400 - - - figure legend:Fig. 4c|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/09/28 2020/10/13 - rogid:e8j47togv1uhkm+TwhWyG6OxiiE9606 - false - sufficient binding region:704..704-897..897(IPR002589) - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody)