#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:K9N7C7-PRO_0000422451 intact:EBI-26356082 intact:EBI-25594390 - psi-mi:k9n7c7-pro_0000422451(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:h4_rna(display_short)|psi-mi:EBI-26356082(display_long) psi-mi:"MI:0920"(ribonuclease assay) Ogando et al. (2020) imex:IM-28365|pubmed:32938769 taxid:1263720(cvemc)|taxid:1263720("Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1)") taxid:32630(synthetic construct)|taxid:32630(synthetic construct) psi-mi:"MI:0902"(rna cleavage) psi-mi:"MI:0469"(IntAct) intact:EBI-26356080|imex:IM-28365-1 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0320"(ribonucleic acid) intact:EBI-25591996(chain-parent) - go:"GO:0004527"(exonuclease activity) chain-seq-start:5909|chain-seq-end:6432 - figure legend:7,8,9,10|comment:Trace activity of Nsp14 alone was seen.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/09/17 2020/09/23 rogid:h6Z4Ydarw7TLx9V8OruEqQ7k47I1263720 - - false his tag:n-n 32p radiolabel:1-1 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) intact:EBI-26356082 uniprotkb:K9N7C7-PRO_0000422448 - intact:EBI-25594384 psi-mi:h4_rna(display_short)|psi-mi:EBI-26356082(display_long) psi-mi:k9n7c7-pro_0000422448(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0920"(ribonuclease assay) Ogando et al. (2020) imex:IM-28365|pubmed:32938769 taxid:32630(synthetic construct)|taxid:32630(synthetic construct) taxid:1263720(cvemc)|taxid:1263720("Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1)") psi-mi:"MI:0902"(rna cleavage) psi-mi:"MI:0469"(IntAct) intact:EBI-26356187|imex:IM-28365-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0840"(stimulator) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0320"(ribonucleic acid) psi-mi:"MI:0326"(protein) - intact:EBI-25591996(chain-parent) go:"GO:0004527"(exonuclease activity) - chain-seq-start:4238|chain-seq-end:4377 figure legend:7,8,9,10|comment:MERS-CoV nsp14 ExoN activity was found to be stimulated by 425 nsp10 in a dose-dependent manner.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/09/17 2020/09/23 - rogid:+P46ulRZ4DcqWX5MiCofIcaUyCs1263720 - false 32p radiolabel:1-1 his tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) intact:EBI-26356082 uniprotkb:K9N7C7-PRO_0000422451 - intact:EBI-25594390 psi-mi:h4_rna(display_short)|psi-mi:EBI-26356082(display_long) psi-mi:k9n7c7-pro_0000422451(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0920"(ribonuclease assay) Ogando et al. (2020) imex:IM-28365|pubmed:32938769 taxid:32630(synthetic construct)|taxid:32630(synthetic construct) taxid:1263720(cvemc)|taxid:1263720("Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1)") psi-mi:"MI:0902"(rna cleavage) psi-mi:"MI:0469"(IntAct) intact:EBI-26356187|imex:IM-28365-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0320"(ribonucleic acid) psi-mi:"MI:0326"(protein) - intact:EBI-25591996(chain-parent) go:"GO:0004527"(exonuclease activity) - chain-seq-start:5909|chain-seq-end:6432 figure legend:7,8,9,10|comment:MERS-CoV nsp14 ExoN activity was found to be stimulated by 425 nsp10 in a dose-dependent manner.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/09/17 2020/09/23 - rogid:h6Z4Ydarw7TLx9V8OruEqQ7k47I1263720 - false 32p radiolabel:1-1 mutation decreasing interaction rate:90-90|mutation decreasing interaction rate:92-92|mutation decreasing interaction rate:268-268|mutation disrupting interaction rate:191-191|mutation disrupting interaction rate:273-273|mutation decreasing interaction rate:331-331|mutation decreasing interaction rate:310-310|his tag:n-n|mutation disrupting interaction rate:90-90,92-92|mutation decreasing interaction rate:191-191|mutation decreasing interaction rate:229-229 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) intact:EBI-26356082 uniprotkb:P0DTD1-PRO_0000449628 - intact:EBI-25475880 psi-mi:h4_rna(display_short)|psi-mi:EBI-26356082(display_long) psi-mi:p0dtd1-pro_0000449628(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0920"(ribonuclease assay) Ogando et al. (2020) imex:IM-28365|pubmed:32938769 taxid:32630(synthetic construct)|taxid:32630(synthetic construct) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0902"(rna cleavage) psi-mi:"MI:0469"(IntAct) intact:EBI-26356262|imex:IM-28365-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0840"(stimulator) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0320"(ribonucleic acid) psi-mi:"MI:0326"(protein) - intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) go:"GO:0004527"(exonuclease activity) - chain-seq-start:4254|chain-seq-end:4392 figure legend:9|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/09/17 2020/09/24 - rogid:L4eD+20oc1IdNFJ9By3H2uun6L02697049 - false 32p radiolabel:1-1 his tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) intact:EBI-26356082 uniprotkb:P0DTD1-PRO_0000449631 - intact:EBI-25475920 psi-mi:h4_rna(display_short)|psi-mi:EBI-26356082(display_long) psi-mi:p0dtd1-pro_0000449631(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0920"(ribonuclease assay) Ogando et al. (2020) imex:IM-28365|pubmed:32938769 taxid:32630(synthetic construct)|taxid:32630(synthetic construct) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0902"(rna cleavage) psi-mi:"MI:0469"(IntAct) intact:EBI-26356262|imex:IM-28365-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0320"(ribonucleic acid) psi-mi:"MI:0326"(protein) - intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) go:"GO:0004527"(exonuclease activity) - chain-seq-start:5926|chain-seq-end:6452 figure legend:9|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/09/17 2020/09/24 - rogid:LpGB5BQU5uhWK/60422jkiKHRL82697049 - false 32p radiolabel:1-1 his tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) intact:EBI-26356082 uniprotkb:K9N7C7-PRO_0000422448 - intact:EBI-25594384 psi-mi:h4_rna(display_short)|psi-mi:EBI-26356082(display_long) psi-mi:k9n7c7-pro_0000422448(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0920"(ribonuclease assay) Ogando et al. (2020) imex:IM-28365|pubmed:32938769 taxid:32630(synthetic construct)|taxid:32630(synthetic construct) taxid:1263720(cvemc)|taxid:1263720("Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1)") psi-mi:"MI:0902"(rna cleavage) psi-mi:"MI:0469"(IntAct) intact:EBI-26356311|imex:IM-28365-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0840"(stimulator) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0320"(ribonucleic acid) psi-mi:"MI:0326"(protein) - intact:EBI-25591996(chain-parent) go:"GO:0004527"(exonuclease activity) - chain-seq-start:4238|chain-seq-end:4377 figure legend:9|comment:SARS Nsp14 +MERS Nsp10|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/09/17 2020/09/24 - rogid:+P46ulRZ4DcqWX5MiCofIcaUyCs1263720 - false 32p radiolabel:1-1 his tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) intact:EBI-26356082 uniprotkb:P0DTD1-PRO_0000449631 - intact:EBI-25475920 psi-mi:h4_rna(display_short)|psi-mi:EBI-26356082(display_long) psi-mi:p0dtd1-pro_0000449631(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0920"(ribonuclease assay) Ogando et al. (2020) imex:IM-28365|pubmed:32938769 taxid:32630(synthetic construct)|taxid:32630(synthetic construct) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0902"(rna cleavage) psi-mi:"MI:0469"(IntAct) intact:EBI-26356311|imex:IM-28365-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0320"(ribonucleic acid) psi-mi:"MI:0326"(protein) - intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) go:"GO:0004527"(exonuclease activity) - chain-seq-start:5926|chain-seq-end:6452 figure legend:9|comment:SARS Nsp14 +MERS Nsp10|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/09/17 2020/09/24 - rogid:LpGB5BQU5uhWK/60422jkiKHRL82697049 - false 32p radiolabel:1-1 his tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) intact:EBI-26356082 uniprotkb:P0DTD1-PRO_0000449628 - intact:EBI-25475880 psi-mi:h4_rna(display_short)|psi-mi:EBI-26356082(display_long) psi-mi:p0dtd1-pro_0000449628(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0920"(ribonuclease assay) Ogando et al. (2020) imex:IM-28365|pubmed:32938769 taxid:32630(synthetic construct)|taxid:32630(synthetic construct) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0902"(rna cleavage) psi-mi:"MI:0469"(IntAct) intact:EBI-26356326|imex:IM-28365-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0840"(stimulator) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0320"(ribonucleic acid) psi-mi:"MI:0326"(protein) - intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) go:"GO:0004527"(exonuclease activity) - chain-seq-start:4254|chain-seq-end:4392 figure legend:9|comment:MERS Nsp14 + SARS Nsp10|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/09/17 2020/09/24 - rogid:L4eD+20oc1IdNFJ9By3H2uun6L02697049 - false 32p radiolabel:1-1 his tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) intact:EBI-26356082 uniprotkb:P0DTD1-PRO_0000449631 - intact:EBI-25475920 psi-mi:h4_rna(display_short)|psi-mi:EBI-26356082(display_long) psi-mi:p0dtd1-pro_0000449631(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0920"(ribonuclease assay) Ogando et al. (2020) imex:IM-28365|pubmed:32938769 taxid:32630(synthetic construct)|taxid:32630(synthetic construct) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0902"(rna cleavage) psi-mi:"MI:0469"(IntAct) intact:EBI-26356326|imex:IM-28365-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0320"(ribonucleic acid) psi-mi:"MI:0326"(protein) - intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) go:"GO:0004527"(exonuclease activity) - chain-seq-start:5926|chain-seq-end:6452 figure legend:9|comment:MERS Nsp14 + SARS Nsp10|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/09/17 2020/09/24 - rogid:LpGB5BQU5uhWK/60422jkiKHRL82697049 - false 32p radiolabel:1-1 his tag:n-n|mutation decreasing interaction rate:90-90,92-92 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:P0DTD1-PRO_0000449631 intact:EBI-26356082 intact:EBI-25475920 - psi-mi:p0dtd1-pro_0000449631(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:h4_rna(display_short)|psi-mi:EBI-26356082(display_long) psi-mi:"MI:0920"(ribonuclease assay) Ogando et al. (2020) imex:IM-28365|pubmed:32938769 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:32630(synthetic construct)|taxid:32630(synthetic construct) psi-mi:"MI:0902"(rna cleavage) psi-mi:"MI:0469"(IntAct) intact:EBI-26356356|imex:IM-28365-11 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0320"(ribonucleic acid) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) - go:"GO:0004527"(exonuclease activity) chain-seq-start:5926|chain-seq-end:6452 - figure legend:9|comment:Trace activity of Nsp14 alone was seen.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/09/17 2020/09/24 rogid:LpGB5BQU5uhWK/60422jkiKHRL82697049 - - false his tag:n-n 32p radiolabel:1-1 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) chebi:"CHEBI:143973" uniprotkb:K9N7C7-PRO_0000422451 intact:EBI-26356422 intact:EBI-25594390 psi-mi:"5'-end (5'-triphospho-guanosine)-adenosine(3-) residue"(display_short)|psi-mi:"CHEBI:143973"(display_long)|intact:"a 5'-end (5'-triphospho-guanosine)-adenosine residue"(synonym) psi-mi:k9n7c7-pro_0000422451(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0516"(methyltransferase radiometric assay) Ogando et al. (2020) imex:IM-28365|pubmed:32938769 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:1263720(cvemc)|taxid:1263720("Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1)") psi-mi:"MI:0213"(methylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26356451|imex:IM-28365-13 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - intact:EBI-25591996(chain-parent) go:"GO:0008168"(methyltransferase activity) - chain-seq-start:5909|chain-seq-end:6432 figure legend:11|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/09/17 2020/09/24 - rogid:h6Z4Ydarw7TLx9V8OruEqQ7k47I1263720 - false - mutation with no effect:90-90|mutation with no effect:92-92|mutation with no effect:268-268|mutation with no effect:191-191|mutation with no effect:273-273|mutation disrupting interaction rate:331-331|mutation disrupting interaction rate:310-310|his tag:n-n|mutation with no effect:90-90,92-92|mutation with no effect:191-191|mutation with no effect:229-229 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)