#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
wwpdb:7ctt	uniprotkb:P0DTD1-PRO_0000449630	intact:EBI-25564960|wwpdb:6xqb|emdb:EMD-22288|wwpdb:6M71|wwpdb:7btf|emdb:EMD-30178|emdb:EMD-30127|intenz:2.7.7.48|wwpdb:7bv2|emdb:EMD-30210|wwpdb:7bv1|emdb:EMD-30209|wwpdb:6x2g|wwpdb:7bw4|emdb:EMD-30226|wwpdb:7l1f|emdb:EMD-23109|wwpdb:6yyt|emdb:EMD-11007|wwpdb:7c2k|emdb:EMD-30275|wwpdb:7bzf|emdb:EMD-30252|reactome:R-COV-9691364|wwpdb:7aap|emdb:EMD-11692|wwpdb:7d4f|emdb:EMD-30572|emdb:EMD-23009|wwpdb:7krp|wwpdb:7b3b|emdb:EMD-11993|wwpdb:7b3c|emdb:EMD-11994|wwpdb:7b3d|emdb:EMD-11995|rhea:"RHEA:21248"|wwpdb:7ozv|emdb:EMD-13138|wwpdb:7ozu|emdb:EMD-13135|wwpdb:7oyg|emdb:EMD-13116	intact:EBI-25475888	psi-mi:nsp7-nsp8-nsp12_sars2(display_short)|psi-mi:7ctt(display_long)|intact:SARS-CoV-2 polymerase complex(complex recommended name)|intact:"NSP7:2xNSP8:NSP12"(complex systematic name)|intact:replication-transcription complex(complex synonym)|intact:replication and transcription complex(complex synonym)|intact:RTC(complex synonym)|intact:central RTC(complex synonym)|intact:C-RTC(complex synonym)|intact:holo-RdRp complex(complex synonym)|intact:holo-RNA-dependent RNA polymerase complex(complex synonym)	psi-mi:p0dtd1-pro_0000449630(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0410"(3D electron microscopy)	Chen et al. (2020)	pubmed:32783916|imex:IM-28291	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25816865|emdb:EMD-22160|wwpdb:6XEZ|imex:IM-28291-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	intact:EBI-25506373(exp-evidence)|pubmed:32277040(see-also)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0039694"(viral RNA genome replication)|efo:"EFO:0000694"(see-also)|pubmed:16228002(see-also)|go:"GO:0031381"(viral RNA-directed RNA polymerase complex)|pubmed:19875418(see-also)|pubmed:31138817(see-also)|pubmed:31987001(see-also)|pubmed:18255185(see-also)|complex portal:CPX-5742(complex-primary)|pubmed:32015508(see-also)|evidence ontology:"ECO:0000353"	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	curated-complex:"RNA-directed 5'-3' RNA polymerase of the SARS-CoV-2 coronavirus which consists of the main polymerase protein NSP12 and a stoichiometric variant of the primase complex (CPX-5690). Extends partially double-stranded RNA templates and is probably also required for transcription initiation, though the mechanism for this has yet to be determined. Complex formation enhances dsRNA binding of the individual protomers."|complex-assembly:Heterotetramer|disease:"Severe acute respiratory syndrome (SARS) [EFO:0000694]: A viral respiratory infection caused by the SARS coronavirus. It is transmitted through close person-to-person contact. It is manifested with high fever, headache, dry cough and myalgias. It may progress to pneumonia and cause death."|complex-properties:"Primase complex without polymerase has a different stoichiometry (8:8). NSP12 possesses conserved motifs involved in template binding, NTP binding, and polymerization that assume a structure resembling a cupped “right hand”. The NSP7-NSP8 heterodimer binds to the index finger loop and may facilitates the interaction of NSP12 with additional components of the RNA synthesis machinery. The second NSP8 molecule binds close to the RNA template-binding channel."	chain-seq-start:5325|chain-seq-end:5925	figure legend:Table S1|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/08/18	2020/09/03	-	rogid:F98KM8XJ6ElyhUel43fFsarYA3g2697049	-	false	-	-	1	2	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
wwpdb:7ctt	intact:EBI-25816901	intact:EBI-25564960|wwpdb:6xqb|emdb:EMD-22288|wwpdb:6M71|wwpdb:7btf|emdb:EMD-30178|emdb:EMD-30127|intenz:2.7.7.48|wwpdb:7bv2|emdb:EMD-30210|wwpdb:7bv1|emdb:EMD-30209|wwpdb:6x2g|wwpdb:7bw4|emdb:EMD-30226|wwpdb:7l1f|emdb:EMD-23109|wwpdb:6yyt|emdb:EMD-11007|wwpdb:7c2k|emdb:EMD-30275|wwpdb:7bzf|emdb:EMD-30252|reactome:R-COV-9691364|wwpdb:7aap|emdb:EMD-11692|wwpdb:7d4f|emdb:EMD-30572|emdb:EMD-23009|wwpdb:7krp|wwpdb:7b3b|emdb:EMD-11993|wwpdb:7b3c|emdb:EMD-11994|wwpdb:7b3d|emdb:EMD-11995|rhea:"RHEA:21248"|wwpdb:7ozv|emdb:EMD-13138|wwpdb:7ozu|emdb:EMD-13135|wwpdb:7oyg|emdb:EMD-13116	-	psi-mi:nsp7-nsp8-nsp12_sars2(display_short)|psi-mi:7ctt(display_long)|intact:SARS-CoV-2 polymerase complex(complex recommended name)|intact:"NSP7:2xNSP8:NSP12"(complex systematic name)|intact:replication-transcription complex(complex synonym)|intact:replication and transcription complex(complex synonym)|intact:RTC(complex synonym)|intact:central RTC(complex synonym)|intact:C-RTC(complex synonym)|intact:holo-RdRp complex(complex synonym)|intact:holo-RNA-dependent RNA polymerase complex(complex synonym)	psi-mi:product-rna(display_short)|psi-mi:EBI-25816901(display_long)	psi-mi:"MI:0410"(3D electron microscopy)	Chen et al. (2020)	pubmed:32783916|imex:IM-28291	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:32630(synthetic construct)|taxid:32630(synthetic construct)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25816865|emdb:EMD-22160|wwpdb:6XEZ|imex:IM-28291-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:2359"(ds rna)	intact:EBI-25506373(exp-evidence)|pubmed:32277040(see-also)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0039694"(viral RNA genome replication)|efo:"EFO:0000694"(see-also)|pubmed:16228002(see-also)|go:"GO:0031381"(viral RNA-directed RNA polymerase complex)|pubmed:19875418(see-also)|pubmed:31138817(see-also)|pubmed:31987001(see-also)|pubmed:18255185(see-also)|complex portal:CPX-5742(complex-primary)|pubmed:32015508(see-also)|evidence ontology:"ECO:0000353"	-	-	curated-complex:"RNA-directed 5'-3' RNA polymerase of the SARS-CoV-2 coronavirus which consists of the main polymerase protein NSP12 and a stoichiometric variant of the primase complex (CPX-5690). Extends partially double-stranded RNA templates and is probably also required for transcription initiation, though the mechanism for this has yet to be determined. Complex formation enhances dsRNA binding of the individual protomers."|complex-assembly:Heterotetramer|disease:"Severe acute respiratory syndrome (SARS) [EFO:0000694]: A viral respiratory infection caused by the SARS coronavirus. It is transmitted through close person-to-person contact. It is manifested with high fever, headache, dry cough and myalgias. It may progress to pneumonia and cause death."|complex-properties:"Primase complex without polymerase has a different stoichiometry (8:8). NSP12 possesses conserved motifs involved in template binding, NTP binding, and polymerization that assume a structure resembling a cupped “right hand”. The NSP7-NSP8 heterodimer binds to the index finger loop and may facilitates the interaction of NSP12 with additional components of the RNA synthesis machinery. The second NSP8 molecule binds close to the RNA template-binding channel."	comment:"NCBI and Ensembl (BLAT/BLAST) give NO matches.   (UCSC BLAT gives a partial match to  chr14:70927135-70927153)"	figure legend:Table S1|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/08/18	2020/09/03	-	-	-	false	-	sufficient binding region:?-?	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
wwpdb:7ctt	intact:EBI-25816965	intact:EBI-25564960|wwpdb:6xqb|emdb:EMD-22288|wwpdb:6M71|wwpdb:7btf|emdb:EMD-30178|emdb:EMD-30127|intenz:2.7.7.48|wwpdb:7bv2|emdb:EMD-30210|wwpdb:7bv1|emdb:EMD-30209|wwpdb:6x2g|wwpdb:7bw4|emdb:EMD-30226|wwpdb:7l1f|emdb:EMD-23109|wwpdb:6yyt|emdb:EMD-11007|wwpdb:7c2k|emdb:EMD-30275|wwpdb:7bzf|emdb:EMD-30252|reactome:R-COV-9691364|wwpdb:7aap|emdb:EMD-11692|wwpdb:7d4f|emdb:EMD-30572|emdb:EMD-23009|wwpdb:7krp|wwpdb:7b3b|emdb:EMD-11993|wwpdb:7b3c|emdb:EMD-11994|wwpdb:7b3d|emdb:EMD-11995|rhea:"RHEA:21248"|wwpdb:7ozv|emdb:EMD-13138|wwpdb:7ozu|emdb:EMD-13135|wwpdb:7oyg|emdb:EMD-13116	-	psi-mi:nsp7-nsp8-nsp12_sars2(display_short)|psi-mi:7ctt(display_long)|intact:SARS-CoV-2 polymerase complex(complex recommended name)|intact:"NSP7:2xNSP8:NSP12"(complex systematic name)|intact:replication-transcription complex(complex synonym)|intact:replication and transcription complex(complex synonym)|intact:RTC(complex synonym)|intact:central RTC(complex synonym)|intact:C-RTC(complex synonym)|intact:holo-RdRp complex(complex synonym)|intact:holo-RNA-dependent RNA polymerase complex(complex synonym)	psi-mi:template-rna(display_short)|psi-mi:EBI-25816965(display_long)	psi-mi:"MI:0410"(3D electron microscopy)	Chen et al. (2020)	pubmed:32783916|imex:IM-28291	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:32630(synthetic construct)|taxid:32630(synthetic construct)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25816865|emdb:EMD-22160|wwpdb:6XEZ|imex:IM-28291-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0318"(nucleic acid)	intact:EBI-25506373(exp-evidence)|pubmed:32277040(see-also)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0039694"(viral RNA genome replication)|efo:"EFO:0000694"(see-also)|pubmed:16228002(see-also)|go:"GO:0031381"(viral RNA-directed RNA polymerase complex)|pubmed:19875418(see-also)|pubmed:31138817(see-also)|pubmed:31987001(see-also)|pubmed:18255185(see-also)|complex portal:CPX-5742(complex-primary)|pubmed:32015508(see-also)|evidence ontology:"ECO:0000353"	-	-	curated-complex:"RNA-directed 5'-3' RNA polymerase of the SARS-CoV-2 coronavirus which consists of the main polymerase protein NSP12 and a stoichiometric variant of the primase complex (CPX-5690). Extends partially double-stranded RNA templates and is probably also required for transcription initiation, though the mechanism for this has yet to be determined. Complex formation enhances dsRNA binding of the individual protomers."|complex-assembly:Heterotetramer|disease:"Severe acute respiratory syndrome (SARS) [EFO:0000694]: A viral respiratory infection caused by the SARS coronavirus. It is transmitted through close person-to-person contact. It is manifested with high fever, headache, dry cough and myalgias. It may progress to pneumonia and cause death."|complex-properties:"Primase complex without polymerase has a different stoichiometry (8:8). NSP12 possesses conserved motifs involved in template binding, NTP binding, and polymerization that assume a structure resembling a cupped “right hand”. The NSP7-NSP8 heterodimer binds to the index finger loop and may facilitates the interaction of NSP12 with additional components of the RNA synthesis machinery. The second NSP8 molecule binds close to the RNA template-binding channel."	comment:"NCBI Blast gives partial match to NC_045512.2 [29831-29870]  (SARS2 complete genome)  for residues 1-40."	figure legend:Table S1|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/08/18	2020/09/03	-	-	-	false	-	sufficient binding region:?-?	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
intact:EBI-25816965	intact:EBI-25816901	-	-	psi-mi:template-rna(display_short)|psi-mi:EBI-25816965(display_long)	psi-mi:product-rna(display_short)|psi-mi:EBI-25816901(display_long)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Chen et al. (2020)	pubmed:32783916|imex:IM-28291	taxid:32630(synthetic construct)|taxid:32630(synthetic construct)	taxid:32630(synthetic construct)|taxid:32630(synthetic construct)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25817083|imex:IM-28291-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0318"(nucleic acid)	psi-mi:"MI:2359"(ds rna)	-	-	-	comment:"NCBI Blast gives partial match to NC_045512.2 [29831-29870]  (SARS2 complete genome)  for residues 1-40."	comment:"NCBI and Ensembl (BLAT/BLAST) give NO matches.   (UCSC BLAT gives a partial match to  chr14:70927135-70927153)"	figure legend:Figure 1B, Lane 6+7|comment:Addition of ADP-AlF3, which inhibits nsp13 ATPase activity, sharpened the  band.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/08/18	2020/09/03	-	-	-	false	sufficient binding region:?-?	sufficient binding region:?-?	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
intact:EBI-25816965	uniprotkb:P0DTD1-PRO_0000449630	-	intact:EBI-25475888	psi-mi:template-rna(display_short)|psi-mi:EBI-25816965(display_long)	psi-mi:p0dtd1-pro_0000449630(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Chen et al. (2020)	pubmed:32783916|imex:IM-28291	taxid:32630(synthetic construct)|taxid:32630(synthetic construct)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25817083|imex:IM-28291-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0318"(nucleic acid)	psi-mi:"MI:0326"(protein)	-	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	comment:"NCBI Blast gives partial match to NC_045512.2 [29831-29870]  (SARS2 complete genome)  for residues 1-40."	chain-seq-start:5325|chain-seq-end:5925	figure legend:Figure 1B, Lane 6+7|comment:Addition of ADP-AlF3, which inhibits nsp13 ATPase activity, sharpened the  band.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/08/18	2020/09/03	-	rogid:F98KM8XJ6ElyhUel43fFsarYA3g2697049	-	false	sufficient binding region:?-?	-	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
intact:EBI-25816965	wwpdb:7ctt	-	intact:EBI-25564960|wwpdb:6xqb|emdb:EMD-22288|wwpdb:6M71|wwpdb:7btf|emdb:EMD-30178|emdb:EMD-30127|intenz:2.7.7.48|wwpdb:7bv2|emdb:EMD-30210|wwpdb:7bv1|emdb:EMD-30209|wwpdb:6x2g|wwpdb:7bw4|emdb:EMD-30226|wwpdb:7l1f|emdb:EMD-23109|wwpdb:6yyt|emdb:EMD-11007|wwpdb:7c2k|emdb:EMD-30275|wwpdb:7bzf|emdb:EMD-30252|reactome:R-COV-9691364|wwpdb:7aap|emdb:EMD-11692|wwpdb:7d4f|emdb:EMD-30572|emdb:EMD-23009|wwpdb:7krp|wwpdb:7b3b|emdb:EMD-11993|wwpdb:7b3c|emdb:EMD-11994|wwpdb:7b3d|emdb:EMD-11995|rhea:"RHEA:21248"|wwpdb:7ozv|emdb:EMD-13138|wwpdb:7ozu|emdb:EMD-13135|wwpdb:7oyg|emdb:EMD-13116	psi-mi:template-rna(display_short)|psi-mi:EBI-25816965(display_long)	psi-mi:nsp7-nsp8-nsp12_sars2(display_short)|psi-mi:7ctt(display_long)|intact:SARS-CoV-2 polymerase complex(complex recommended name)|intact:"NSP7:2xNSP8:NSP12"(complex systematic name)|intact:replication-transcription complex(complex synonym)|intact:replication and transcription complex(complex synonym)|intact:RTC(complex synonym)|intact:central RTC(complex synonym)|intact:C-RTC(complex synonym)|intact:holo-RdRp complex(complex synonym)|intact:holo-RNA-dependent RNA polymerase complex(complex synonym)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Chen et al. (2020)	pubmed:32783916|imex:IM-28291	taxid:32630(synthetic construct)|taxid:32630(synthetic construct)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25817083|imex:IM-28291-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0318"(nucleic acid)	psi-mi:"MI:1302"(stable complex)	-	intact:EBI-25506373(exp-evidence)|pubmed:32277040(see-also)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0039694"(viral RNA genome replication)|efo:"EFO:0000694"(see-also)|pubmed:16228002(see-also)|go:"GO:0031381"(viral RNA-directed RNA polymerase complex)|pubmed:19875418(see-also)|pubmed:31138817(see-also)|pubmed:31987001(see-also)|pubmed:18255185(see-also)|complex portal:CPX-5742(complex-primary)|pubmed:32015508(see-also)|evidence ontology:"ECO:0000353"	-	comment:"NCBI Blast gives partial match to NC_045512.2 [29831-29870]  (SARS2 complete genome)  for residues 1-40."	curated-complex:"RNA-directed 5'-3' RNA polymerase of the SARS-CoV-2 coronavirus which consists of the main polymerase protein NSP12 and a stoichiometric variant of the primase complex (CPX-5690). Extends partially double-stranded RNA templates and is probably also required for transcription initiation, though the mechanism for this has yet to be determined. Complex formation enhances dsRNA binding of the individual protomers."|complex-assembly:Heterotetramer|disease:"Severe acute respiratory syndrome (SARS) [EFO:0000694]: A viral respiratory infection caused by the SARS coronavirus. It is transmitted through close person-to-person contact. It is manifested with high fever, headache, dry cough and myalgias. It may progress to pneumonia and cause death."|complex-properties:"Primase complex without polymerase has a different stoichiometry (8:8). NSP12 possesses conserved motifs involved in template binding, NTP binding, and polymerization that assume a structure resembling a cupped “right hand”. The NSP7-NSP8 heterodimer binds to the index finger loop and may facilitates the interaction of NSP12 with additional components of the RNA synthesis machinery. The second NSP8 molecule binds close to the RNA template-binding channel."	figure legend:Figure 1B, Lane 6+7|comment:Addition of ADP-AlF3, which inhibits nsp13 ATPase activity, sharpened the  band.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/08/18	2020/09/03	-	-	-	false	sufficient binding region:?-?	-	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
intact:EBI-25816965	wwpdb:7ctt	-	intact:EBI-25564960|wwpdb:6xqb|emdb:EMD-22288|wwpdb:6M71|wwpdb:7btf|emdb:EMD-30178|emdb:EMD-30127|intenz:2.7.7.48|wwpdb:7bv2|emdb:EMD-30210|wwpdb:7bv1|emdb:EMD-30209|wwpdb:6x2g|wwpdb:7bw4|emdb:EMD-30226|wwpdb:7l1f|emdb:EMD-23109|wwpdb:6yyt|emdb:EMD-11007|wwpdb:7c2k|emdb:EMD-30275|wwpdb:7bzf|emdb:EMD-30252|reactome:R-COV-9691364|wwpdb:7aap|emdb:EMD-11692|wwpdb:7d4f|emdb:EMD-30572|emdb:EMD-23009|wwpdb:7krp|wwpdb:7b3b|emdb:EMD-11993|wwpdb:7b3c|emdb:EMD-11994|wwpdb:7b3d|emdb:EMD-11995|rhea:"RHEA:21248"|wwpdb:7ozv|emdb:EMD-13138|wwpdb:7ozu|emdb:EMD-13135|wwpdb:7oyg|emdb:EMD-13116	psi-mi:template-rna(display_short)|psi-mi:EBI-25816965(display_long)	psi-mi:nsp7-nsp8-nsp12_sars2(display_short)|psi-mi:7ctt(display_long)|intact:SARS-CoV-2 polymerase complex(complex recommended name)|intact:"NSP7:2xNSP8:NSP12"(complex systematic name)|intact:replication-transcription complex(complex synonym)|intact:replication and transcription complex(complex synonym)|intact:RTC(complex synonym)|intact:central RTC(complex synonym)|intact:C-RTC(complex synonym)|intact:holo-RdRp complex(complex synonym)|intact:holo-RNA-dependent RNA polymerase complex(complex synonym)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Chen et al. (2020)	pubmed:32783916|imex:IM-28291	taxid:32630(synthetic construct)|taxid:32630(synthetic construct)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25817096|imex:IM-28291-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0318"(nucleic acid)	psi-mi:"MI:1302"(stable complex)	-	intact:EBI-25506373(exp-evidence)|pubmed:32277040(see-also)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0039694"(viral RNA genome replication)|efo:"EFO:0000694"(see-also)|pubmed:16228002(see-also)|go:"GO:0031381"(viral RNA-directed RNA polymerase complex)|pubmed:19875418(see-also)|pubmed:31138817(see-also)|pubmed:31987001(see-also)|pubmed:18255185(see-also)|complex portal:CPX-5742(complex-primary)|pubmed:32015508(see-also)|evidence ontology:"ECO:0000353"	-	comment:"NCBI Blast gives partial match to NC_045512.2 [29831-29870]  (SARS2 complete genome)  for residues 1-40."	curated-complex:"RNA-directed 5'-3' RNA polymerase of the SARS-CoV-2 coronavirus which consists of the main polymerase protein NSP12 and a stoichiometric variant of the primase complex (CPX-5690). Extends partially double-stranded RNA templates and is probably also required for transcription initiation, though the mechanism for this has yet to be determined. Complex formation enhances dsRNA binding of the individual protomers."|complex-assembly:Heterotetramer|disease:"Severe acute respiratory syndrome (SARS) [EFO:0000694]: A viral respiratory infection caused by the SARS coronavirus. It is transmitted through close person-to-person contact. It is manifested with high fever, headache, dry cough and myalgias. It may progress to pneumonia and cause death."|complex-properties:"Primase complex without polymerase has a different stoichiometry (8:8). NSP12 possesses conserved motifs involved in template binding, NTP binding, and polymerization that assume a structure resembling a cupped “right hand”. The NSP7-NSP8 heterodimer binds to the index finger loop and may facilitates the interaction of NSP12 with additional components of the RNA synthesis machinery. The second NSP8 molecule binds close to the RNA template-binding channel."	figure legend:Figure 1B, Lanes 3,6,7.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/08/18	2020/09/03	-	-	-	false	sufficient binding region:?-?	-	1	1	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
intact:EBI-25816965	intact:EBI-25816901	-	-	psi-mi:template-rna(display_short)|psi-mi:EBI-25816965(display_long)	psi-mi:product-rna(display_short)|psi-mi:EBI-25816901(display_long)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Chen et al. (2020)	pubmed:32783916|imex:IM-28291	taxid:32630(synthetic construct)|taxid:32630(synthetic construct)	taxid:32630(synthetic construct)|taxid:32630(synthetic construct)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25817096|imex:IM-28291-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0318"(nucleic acid)	psi-mi:"MI:2359"(ds rna)	-	-	-	comment:"NCBI Blast gives partial match to NC_045512.2 [29831-29870]  (SARS2 complete genome)  for residues 1-40."	comment:"NCBI and Ensembl (BLAT/BLAST) give NO matches.   (UCSC BLAT gives a partial match to  chr14:70927135-70927153)"	figure legend:Figure 1B, Lanes 3,6,7.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/08/18	2020/09/03	-	-	-	false	sufficient binding region:?-?	sufficient binding region:?-?	1	1	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
wwpdb:7ctt	uniprotkb:P0DTD1-PRO_0000449630	intact:EBI-25564960|wwpdb:6xqb|emdb:EMD-22288|wwpdb:6M71|wwpdb:7btf|emdb:EMD-30178|emdb:EMD-30127|intenz:2.7.7.48|wwpdb:7bv2|emdb:EMD-30210|wwpdb:7bv1|emdb:EMD-30209|wwpdb:6x2g|wwpdb:7bw4|emdb:EMD-30226|wwpdb:7l1f|emdb:EMD-23109|wwpdb:6yyt|emdb:EMD-11007|wwpdb:7c2k|emdb:EMD-30275|wwpdb:7bzf|emdb:EMD-30252|reactome:R-COV-9691364|wwpdb:7aap|emdb:EMD-11692|wwpdb:7d4f|emdb:EMD-30572|emdb:EMD-23009|wwpdb:7krp|wwpdb:7b3b|emdb:EMD-11993|wwpdb:7b3c|emdb:EMD-11994|wwpdb:7b3d|emdb:EMD-11995|rhea:"RHEA:21248"|wwpdb:7ozv|emdb:EMD-13138|wwpdb:7ozu|emdb:EMD-13135|wwpdb:7oyg|emdb:EMD-13116	intact:EBI-25475888	psi-mi:nsp7-nsp8-nsp12_sars2(display_short)|psi-mi:7ctt(display_long)|intact:SARS-CoV-2 polymerase complex(complex recommended name)|intact:"NSP7:2xNSP8:NSP12"(complex systematic name)|intact:replication-transcription complex(complex synonym)|intact:replication and transcription complex(complex synonym)|intact:RTC(complex synonym)|intact:central RTC(complex synonym)|intact:C-RTC(complex synonym)|intact:holo-RdRp complex(complex synonym)|intact:holo-RNA-dependent RNA polymerase complex(complex synonym)	psi-mi:p0dtd1-pro_0000449630(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0069"(mass spectrometry studies of complexes)	Chen et al. (2020)	pubmed:32783916|imex:IM-28291	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25817119|imex:IM-28291-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	intact:EBI-25506373(exp-evidence)|pubmed:32277040(see-also)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0039694"(viral RNA genome replication)|efo:"EFO:0000694"(see-also)|pubmed:16228002(see-also)|go:"GO:0031381"(viral RNA-directed RNA polymerase complex)|pubmed:19875418(see-also)|pubmed:31138817(see-also)|pubmed:31987001(see-also)|pubmed:18255185(see-also)|complex portal:CPX-5742(complex-primary)|pubmed:32015508(see-also)|evidence ontology:"ECO:0000353"	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	curated-complex:"RNA-directed 5'-3' RNA polymerase of the SARS-CoV-2 coronavirus which consists of the main polymerase protein NSP12 and a stoichiometric variant of the primase complex (CPX-5690). Extends partially double-stranded RNA templates and is probably also required for transcription initiation, though the mechanism for this has yet to be determined. Complex formation enhances dsRNA binding of the individual protomers."|complex-assembly:Heterotetramer|disease:"Severe acute respiratory syndrome (SARS) [EFO:0000694]: A viral respiratory infection caused by the SARS coronavirus. It is transmitted through close person-to-person contact. It is manifested with high fever, headache, dry cough and myalgias. It may progress to pneumonia and cause death."|complex-properties:"Primase complex without polymerase has a different stoichiometry (8:8). NSP12 possesses conserved motifs involved in template binding, NTP binding, and polymerization that assume a structure resembling a cupped “right hand”. The NSP7-NSP8 heterodimer binds to the index finger loop and may facilitates the interaction of NSP12 with additional components of the RNA synthesis machinery. The second NSP8 molecule binds close to the RNA template-binding channel."	chain-seq-start:5325|chain-seq-end:5925	figure legend:Figure 1C|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/08/18	2020/09/03	-	rogid:F98KM8XJ6ElyhUel43fFsarYA3g2697049	-	false	-	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
wwpdb:7ctt	intact:EBI-25816901	intact:EBI-25564960|wwpdb:6xqb|emdb:EMD-22288|wwpdb:6M71|wwpdb:7btf|emdb:EMD-30178|emdb:EMD-30127|intenz:2.7.7.48|wwpdb:7bv2|emdb:EMD-30210|wwpdb:7bv1|emdb:EMD-30209|wwpdb:6x2g|wwpdb:7bw4|emdb:EMD-30226|wwpdb:7l1f|emdb:EMD-23109|wwpdb:6yyt|emdb:EMD-11007|wwpdb:7c2k|emdb:EMD-30275|wwpdb:7bzf|emdb:EMD-30252|reactome:R-COV-9691364|wwpdb:7aap|emdb:EMD-11692|wwpdb:7d4f|emdb:EMD-30572|emdb:EMD-23009|wwpdb:7krp|wwpdb:7b3b|emdb:EMD-11993|wwpdb:7b3c|emdb:EMD-11994|wwpdb:7b3d|emdb:EMD-11995|rhea:"RHEA:21248"|wwpdb:7ozv|emdb:EMD-13138|wwpdb:7ozu|emdb:EMD-13135|wwpdb:7oyg|emdb:EMD-13116	-	psi-mi:nsp7-nsp8-nsp12_sars2(display_short)|psi-mi:7ctt(display_long)|intact:SARS-CoV-2 polymerase complex(complex recommended name)|intact:"NSP7:2xNSP8:NSP12"(complex systematic name)|intact:replication-transcription complex(complex synonym)|intact:replication and transcription complex(complex synonym)|intact:RTC(complex synonym)|intact:central RTC(complex synonym)|intact:C-RTC(complex synonym)|intact:holo-RdRp complex(complex synonym)|intact:holo-RNA-dependent RNA polymerase complex(complex synonym)	psi-mi:product-rna(display_short)|psi-mi:EBI-25816901(display_long)	psi-mi:"MI:0069"(mass spectrometry studies of complexes)	Chen et al. (2020)	pubmed:32783916|imex:IM-28291	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:32630(synthetic construct)|taxid:32630(synthetic construct)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25817119|imex:IM-28291-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:2359"(ds rna)	intact:EBI-25506373(exp-evidence)|pubmed:32277040(see-also)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0039694"(viral RNA genome replication)|efo:"EFO:0000694"(see-also)|pubmed:16228002(see-also)|go:"GO:0031381"(viral RNA-directed RNA polymerase complex)|pubmed:19875418(see-also)|pubmed:31138817(see-also)|pubmed:31987001(see-also)|pubmed:18255185(see-also)|complex portal:CPX-5742(complex-primary)|pubmed:32015508(see-also)|evidence ontology:"ECO:0000353"	-	-	curated-complex:"RNA-directed 5'-3' RNA polymerase of the SARS-CoV-2 coronavirus which consists of the main polymerase protein NSP12 and a stoichiometric variant of the primase complex (CPX-5690). Extends partially double-stranded RNA templates and is probably also required for transcription initiation, though the mechanism for this has yet to be determined. Complex formation enhances dsRNA binding of the individual protomers."|complex-assembly:Heterotetramer|disease:"Severe acute respiratory syndrome (SARS) [EFO:0000694]: A viral respiratory infection caused by the SARS coronavirus. It is transmitted through close person-to-person contact. It is manifested with high fever, headache, dry cough and myalgias. It may progress to pneumonia and cause death."|complex-properties:"Primase complex without polymerase has a different stoichiometry (8:8). NSP12 possesses conserved motifs involved in template binding, NTP binding, and polymerization that assume a structure resembling a cupped “right hand”. The NSP7-NSP8 heterodimer binds to the index finger loop and may facilitates the interaction of NSP12 with additional components of the RNA synthesis machinery. The second NSP8 molecule binds close to the RNA template-binding channel."	comment:"NCBI and Ensembl (BLAT/BLAST) give NO matches.   (UCSC BLAT gives a partial match to  chr14:70927135-70927153)"	figure legend:Figure 1C|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/08/18	2020/09/03	-	-	-	false	-	sufficient binding region:?-?	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
wwpdb:7ctt	intact:EBI-25816965	intact:EBI-25564960|wwpdb:6xqb|emdb:EMD-22288|wwpdb:6M71|wwpdb:7btf|emdb:EMD-30178|emdb:EMD-30127|intenz:2.7.7.48|wwpdb:7bv2|emdb:EMD-30210|wwpdb:7bv1|emdb:EMD-30209|wwpdb:6x2g|wwpdb:7bw4|emdb:EMD-30226|wwpdb:7l1f|emdb:EMD-23109|wwpdb:6yyt|emdb:EMD-11007|wwpdb:7c2k|emdb:EMD-30275|wwpdb:7bzf|emdb:EMD-30252|reactome:R-COV-9691364|wwpdb:7aap|emdb:EMD-11692|wwpdb:7d4f|emdb:EMD-30572|emdb:EMD-23009|wwpdb:7krp|wwpdb:7b3b|emdb:EMD-11993|wwpdb:7b3c|emdb:EMD-11994|wwpdb:7b3d|emdb:EMD-11995|rhea:"RHEA:21248"|wwpdb:7ozv|emdb:EMD-13138|wwpdb:7ozu|emdb:EMD-13135|wwpdb:7oyg|emdb:EMD-13116	-	psi-mi:nsp7-nsp8-nsp12_sars2(display_short)|psi-mi:7ctt(display_long)|intact:SARS-CoV-2 polymerase complex(complex recommended name)|intact:"NSP7:2xNSP8:NSP12"(complex systematic name)|intact:replication-transcription complex(complex synonym)|intact:replication and transcription complex(complex synonym)|intact:RTC(complex synonym)|intact:central RTC(complex synonym)|intact:C-RTC(complex synonym)|intact:holo-RdRp complex(complex synonym)|intact:holo-RNA-dependent RNA polymerase complex(complex synonym)	psi-mi:template-rna(display_short)|psi-mi:EBI-25816965(display_long)	psi-mi:"MI:0069"(mass spectrometry studies of complexes)	Chen et al. (2020)	pubmed:32783916|imex:IM-28291	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:32630(synthetic construct)|taxid:32630(synthetic construct)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25817119|imex:IM-28291-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0318"(nucleic acid)	intact:EBI-25506373(exp-evidence)|pubmed:32277040(see-also)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0039694"(viral RNA genome replication)|efo:"EFO:0000694"(see-also)|pubmed:16228002(see-also)|go:"GO:0031381"(viral RNA-directed RNA polymerase complex)|pubmed:19875418(see-also)|pubmed:31138817(see-also)|pubmed:31987001(see-also)|pubmed:18255185(see-also)|complex portal:CPX-5742(complex-primary)|pubmed:32015508(see-also)|evidence ontology:"ECO:0000353"	-	-	curated-complex:"RNA-directed 5'-3' RNA polymerase of the SARS-CoV-2 coronavirus which consists of the main polymerase protein NSP12 and a stoichiometric variant of the primase complex (CPX-5690). Extends partially double-stranded RNA templates and is probably also required for transcription initiation, though the mechanism for this has yet to be determined. Complex formation enhances dsRNA binding of the individual protomers."|complex-assembly:Heterotetramer|disease:"Severe acute respiratory syndrome (SARS) [EFO:0000694]: A viral respiratory infection caused by the SARS coronavirus. It is transmitted through close person-to-person contact. It is manifested with high fever, headache, dry cough and myalgias. It may progress to pneumonia and cause death."|complex-properties:"Primase complex without polymerase has a different stoichiometry (8:8). NSP12 possesses conserved motifs involved in template binding, NTP binding, and polymerization that assume a structure resembling a cupped “right hand”. The NSP7-NSP8 heterodimer binds to the index finger loop and may facilitates the interaction of NSP12 with additional components of the RNA synthesis machinery. The second NSP8 molecule binds close to the RNA template-binding channel."	comment:"NCBI Blast gives partial match to NC_045512.2 [29831-29870]  (SARS2 complete genome)  for residues 1-40."	figure legend:Figure 1C|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/08/18	2020/09/03	-	-	-	false	-	sufficient binding region:?-?	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
wwpdb:7ctt	intact:EBI-25816901	intact:EBI-25564960|wwpdb:6xqb|emdb:EMD-22288|wwpdb:6M71|wwpdb:7btf|emdb:EMD-30178|emdb:EMD-30127|intenz:2.7.7.48|wwpdb:7bv2|emdb:EMD-30210|wwpdb:7bv1|emdb:EMD-30209|wwpdb:6x2g|wwpdb:7bw4|emdb:EMD-30226|wwpdb:7l1f|emdb:EMD-23109|wwpdb:6yyt|emdb:EMD-11007|wwpdb:7c2k|emdb:EMD-30275|wwpdb:7bzf|emdb:EMD-30252|reactome:R-COV-9691364|wwpdb:7aap|emdb:EMD-11692|wwpdb:7d4f|emdb:EMD-30572|emdb:EMD-23009|wwpdb:7krp|wwpdb:7b3b|emdb:EMD-11993|wwpdb:7b3c|emdb:EMD-11994|wwpdb:7b3d|emdb:EMD-11995|rhea:"RHEA:21248"|wwpdb:7ozv|emdb:EMD-13138|wwpdb:7ozu|emdb:EMD-13135|wwpdb:7oyg|emdb:EMD-13116	-	psi-mi:nsp7-nsp8-nsp12_sars2(display_short)|psi-mi:7ctt(display_long)|intact:SARS-CoV-2 polymerase complex(complex recommended name)|intact:"NSP7:2xNSP8:NSP12"(complex systematic name)|intact:replication-transcription complex(complex synonym)|intact:replication and transcription complex(complex synonym)|intact:RTC(complex synonym)|intact:central RTC(complex synonym)|intact:C-RTC(complex synonym)|intact:holo-RdRp complex(complex synonym)|intact:holo-RNA-dependent RNA polymerase complex(complex synonym)	psi-mi:product-rna(display_short)|psi-mi:EBI-25816901(display_long)	psi-mi:"MI:0069"(mass spectrometry studies of complexes)	Chen et al. (2020)	pubmed:32783916|imex:IM-28291	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:32630(synthetic construct)|taxid:32630(synthetic construct)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25817132|imex:IM-28291-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:2359"(ds rna)	intact:EBI-25506373(exp-evidence)|pubmed:32277040(see-also)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0039694"(viral RNA genome replication)|efo:"EFO:0000694"(see-also)|pubmed:16228002(see-also)|go:"GO:0031381"(viral RNA-directed RNA polymerase complex)|pubmed:19875418(see-also)|pubmed:31138817(see-also)|pubmed:31987001(see-also)|pubmed:18255185(see-also)|complex portal:CPX-5742(complex-primary)|pubmed:32015508(see-also)|evidence ontology:"ECO:0000353"	-	-	curated-complex:"RNA-directed 5'-3' RNA polymerase of the SARS-CoV-2 coronavirus which consists of the main polymerase protein NSP12 and a stoichiometric variant of the primase complex (CPX-5690). Extends partially double-stranded RNA templates and is probably also required for transcription initiation, though the mechanism for this has yet to be determined. Complex formation enhances dsRNA binding of the individual protomers."|complex-assembly:Heterotetramer|disease:"Severe acute respiratory syndrome (SARS) [EFO:0000694]: A viral respiratory infection caused by the SARS coronavirus. It is transmitted through close person-to-person contact. It is manifested with high fever, headache, dry cough and myalgias. It may progress to pneumonia and cause death."|complex-properties:"Primase complex without polymerase has a different stoichiometry (8:8). NSP12 possesses conserved motifs involved in template binding, NTP binding, and polymerization that assume a structure resembling a cupped “right hand”. The NSP7-NSP8 heterodimer binds to the index finger loop and may facilitates the interaction of NSP12 with additional components of the RNA synthesis machinery. The second NSP8 molecule binds close to the RNA template-binding channel."	comment:"NCBI and Ensembl (BLAT/BLAST) give NO matches.   (UCSC BLAT gives a partial match to  chr14:70927135-70927153)"	figure legend:Figure 1C|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/08/18	2020/08/24	-	-	-	false	-	sufficient binding region:?-?	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
wwpdb:7ctt	intact:EBI-25816965	intact:EBI-25564960|wwpdb:6xqb|emdb:EMD-22288|wwpdb:6M71|wwpdb:7btf|emdb:EMD-30178|emdb:EMD-30127|intenz:2.7.7.48|wwpdb:7bv2|emdb:EMD-30210|wwpdb:7bv1|emdb:EMD-30209|wwpdb:6x2g|wwpdb:7bw4|emdb:EMD-30226|wwpdb:7l1f|emdb:EMD-23109|wwpdb:6yyt|emdb:EMD-11007|wwpdb:7c2k|emdb:EMD-30275|wwpdb:7bzf|emdb:EMD-30252|reactome:R-COV-9691364|wwpdb:7aap|emdb:EMD-11692|wwpdb:7d4f|emdb:EMD-30572|emdb:EMD-23009|wwpdb:7krp|wwpdb:7b3b|emdb:EMD-11993|wwpdb:7b3c|emdb:EMD-11994|wwpdb:7b3d|emdb:EMD-11995|rhea:"RHEA:21248"|wwpdb:7ozv|emdb:EMD-13138|wwpdb:7ozu|emdb:EMD-13135|wwpdb:7oyg|emdb:EMD-13116	-	psi-mi:nsp7-nsp8-nsp12_sars2(display_short)|psi-mi:7ctt(display_long)|intact:SARS-CoV-2 polymerase complex(complex recommended name)|intact:"NSP7:2xNSP8:NSP12"(complex systematic name)|intact:replication-transcription complex(complex synonym)|intact:replication and transcription complex(complex synonym)|intact:RTC(complex synonym)|intact:central RTC(complex synonym)|intact:C-RTC(complex synonym)|intact:holo-RdRp complex(complex synonym)|intact:holo-RNA-dependent RNA polymerase complex(complex synonym)	psi-mi:template-rna(display_short)|psi-mi:EBI-25816965(display_long)	psi-mi:"MI:0069"(mass spectrometry studies of complexes)	Chen et al. (2020)	pubmed:32783916|imex:IM-28291	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:32630(synthetic construct)|taxid:32630(synthetic construct)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25817132|imex:IM-28291-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0318"(nucleic acid)	intact:EBI-25506373(exp-evidence)|pubmed:32277040(see-also)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0039694"(viral RNA genome replication)|efo:"EFO:0000694"(see-also)|pubmed:16228002(see-also)|go:"GO:0031381"(viral RNA-directed RNA polymerase complex)|pubmed:19875418(see-also)|pubmed:31138817(see-also)|pubmed:31987001(see-also)|pubmed:18255185(see-also)|complex portal:CPX-5742(complex-primary)|pubmed:32015508(see-also)|evidence ontology:"ECO:0000353"	-	-	curated-complex:"RNA-directed 5'-3' RNA polymerase of the SARS-CoV-2 coronavirus which consists of the main polymerase protein NSP12 and a stoichiometric variant of the primase complex (CPX-5690). Extends partially double-stranded RNA templates and is probably also required for transcription initiation, though the mechanism for this has yet to be determined. Complex formation enhances dsRNA binding of the individual protomers."|complex-assembly:Heterotetramer|disease:"Severe acute respiratory syndrome (SARS) [EFO:0000694]: A viral respiratory infection caused by the SARS coronavirus. It is transmitted through close person-to-person contact. It is manifested with high fever, headache, dry cough and myalgias. It may progress to pneumonia and cause death."|complex-properties:"Primase complex without polymerase has a different stoichiometry (8:8). NSP12 possesses conserved motifs involved in template binding, NTP binding, and polymerization that assume a structure resembling a cupped “right hand”. The NSP7-NSP8 heterodimer binds to the index finger loop and may facilitates the interaction of NSP12 with additional components of the RNA synthesis machinery. The second NSP8 molecule binds close to the RNA template-binding channel."	comment:"NCBI Blast gives partial match to NC_045512.2 [29831-29870]  (SARS2 complete genome)  for residues 1-40."	figure legend:Figure 1C|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/08/18	2020/08/24	-	-	-	false	-	sufficient binding region:?-?	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
wwpdb:7ctt	intact:EBI-25816901	intact:EBI-25564960|wwpdb:6xqb|emdb:EMD-22288|wwpdb:6M71|wwpdb:7btf|emdb:EMD-30178|emdb:EMD-30127|intenz:2.7.7.48|wwpdb:7bv2|emdb:EMD-30210|wwpdb:7bv1|emdb:EMD-30209|wwpdb:6x2g|wwpdb:7bw4|emdb:EMD-30226|wwpdb:7l1f|emdb:EMD-23109|wwpdb:6yyt|emdb:EMD-11007|wwpdb:7c2k|emdb:EMD-30275|wwpdb:7bzf|emdb:EMD-30252|reactome:R-COV-9691364|wwpdb:7aap|emdb:EMD-11692|wwpdb:7d4f|emdb:EMD-30572|emdb:EMD-23009|wwpdb:7krp|wwpdb:7b3b|emdb:EMD-11993|wwpdb:7b3c|emdb:EMD-11994|wwpdb:7b3d|emdb:EMD-11995|rhea:"RHEA:21248"|wwpdb:7ozv|emdb:EMD-13138|wwpdb:7ozu|emdb:EMD-13135|wwpdb:7oyg|emdb:EMD-13116	-	psi-mi:nsp7-nsp8-nsp12_sars2(display_short)|psi-mi:7ctt(display_long)|intact:SARS-CoV-2 polymerase complex(complex recommended name)|intact:"NSP7:2xNSP8:NSP12"(complex systematic name)|intact:replication-transcription complex(complex synonym)|intact:replication and transcription complex(complex synonym)|intact:RTC(complex synonym)|intact:central RTC(complex synonym)|intact:C-RTC(complex synonym)|intact:holo-RdRp complex(complex synonym)|intact:holo-RNA-dependent RNA polymerase complex(complex synonym)	psi-mi:product-rna(display_short)|psi-mi:EBI-25816901(display_long)	psi-mi:"MI:0071"(molecular sieving)	Chen et al. (2020)	pubmed:32783916|imex:IM-28291	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:32630(synthetic construct)|taxid:32630(synthetic construct)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25817153|imex:IM-28291-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:2359"(ds rna)	intact:EBI-25506373(exp-evidence)|pubmed:32277040(see-also)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0039694"(viral RNA genome replication)|efo:"EFO:0000694"(see-also)|pubmed:16228002(see-also)|go:"GO:0031381"(viral RNA-directed RNA polymerase complex)|pubmed:19875418(see-also)|pubmed:31138817(see-also)|pubmed:31987001(see-also)|pubmed:18255185(see-also)|complex portal:CPX-5742(complex-primary)|pubmed:32015508(see-also)|evidence ontology:"ECO:0000353"	-	-	curated-complex:"RNA-directed 5'-3' RNA polymerase of the SARS-CoV-2 coronavirus which consists of the main polymerase protein NSP12 and a stoichiometric variant of the primase complex (CPX-5690). Extends partially double-stranded RNA templates and is probably also required for transcription initiation, though the mechanism for this has yet to be determined. Complex formation enhances dsRNA binding of the individual protomers."|complex-assembly:Heterotetramer|disease:"Severe acute respiratory syndrome (SARS) [EFO:0000694]: A viral respiratory infection caused by the SARS coronavirus. It is transmitted through close person-to-person contact. It is manifested with high fever, headache, dry cough and myalgias. It may progress to pneumonia and cause death."|complex-properties:"Primase complex without polymerase has a different stoichiometry (8:8). NSP12 possesses conserved motifs involved in template binding, NTP binding, and polymerization that assume a structure resembling a cupped “right hand”. The NSP7-NSP8 heterodimer binds to the index finger loop and may facilitates the interaction of NSP12 with additional components of the RNA synthesis machinery. The second NSP8 molecule binds close to the RNA template-binding channel."	comment:"NCBI and Ensembl (BLAT/BLAST) give NO matches.   (UCSC BLAT gives a partial match to  chr14:70927135-70927153)"	figure legend:Figure S1B|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/08/18	2020/08/24	-	-	-	false	-	sufficient binding region:?-?	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
wwpdb:7ctt	intact:EBI-25816965	intact:EBI-25564960|wwpdb:6xqb|emdb:EMD-22288|wwpdb:6M71|wwpdb:7btf|emdb:EMD-30178|emdb:EMD-30127|intenz:2.7.7.48|wwpdb:7bv2|emdb:EMD-30210|wwpdb:7bv1|emdb:EMD-30209|wwpdb:6x2g|wwpdb:7bw4|emdb:EMD-30226|wwpdb:7l1f|emdb:EMD-23109|wwpdb:6yyt|emdb:EMD-11007|wwpdb:7c2k|emdb:EMD-30275|wwpdb:7bzf|emdb:EMD-30252|reactome:R-COV-9691364|wwpdb:7aap|emdb:EMD-11692|wwpdb:7d4f|emdb:EMD-30572|emdb:EMD-23009|wwpdb:7krp|wwpdb:7b3b|emdb:EMD-11993|wwpdb:7b3c|emdb:EMD-11994|wwpdb:7b3d|emdb:EMD-11995|rhea:"RHEA:21248"|wwpdb:7ozv|emdb:EMD-13138|wwpdb:7ozu|emdb:EMD-13135|wwpdb:7oyg|emdb:EMD-13116	-	psi-mi:nsp7-nsp8-nsp12_sars2(display_short)|psi-mi:7ctt(display_long)|intact:SARS-CoV-2 polymerase complex(complex recommended name)|intact:"NSP7:2xNSP8:NSP12"(complex systematic name)|intact:replication-transcription complex(complex synonym)|intact:replication and transcription complex(complex synonym)|intact:RTC(complex synonym)|intact:central RTC(complex synonym)|intact:C-RTC(complex synonym)|intact:holo-RdRp complex(complex synonym)|intact:holo-RNA-dependent RNA polymerase complex(complex synonym)	psi-mi:template-rna(display_short)|psi-mi:EBI-25816965(display_long)	psi-mi:"MI:0071"(molecular sieving)	Chen et al. (2020)	pubmed:32783916|imex:IM-28291	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:32630(synthetic construct)|taxid:32630(synthetic construct)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25817153|imex:IM-28291-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0318"(nucleic acid)	intact:EBI-25506373(exp-evidence)|pubmed:32277040(see-also)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0039694"(viral RNA genome replication)|efo:"EFO:0000694"(see-also)|pubmed:16228002(see-also)|go:"GO:0031381"(viral RNA-directed RNA polymerase complex)|pubmed:19875418(see-also)|pubmed:31138817(see-also)|pubmed:31987001(see-also)|pubmed:18255185(see-also)|complex portal:CPX-5742(complex-primary)|pubmed:32015508(see-also)|evidence ontology:"ECO:0000353"	-	-	curated-complex:"RNA-directed 5'-3' RNA polymerase of the SARS-CoV-2 coronavirus which consists of the main polymerase protein NSP12 and a stoichiometric variant of the primase complex (CPX-5690). Extends partially double-stranded RNA templates and is probably also required for transcription initiation, though the mechanism for this has yet to be determined. Complex formation enhances dsRNA binding of the individual protomers."|complex-assembly:Heterotetramer|disease:"Severe acute respiratory syndrome (SARS) [EFO:0000694]: A viral respiratory infection caused by the SARS coronavirus. It is transmitted through close person-to-person contact. It is manifested with high fever, headache, dry cough and myalgias. It may progress to pneumonia and cause death."|complex-properties:"Primase complex without polymerase has a different stoichiometry (8:8). NSP12 possesses conserved motifs involved in template binding, NTP binding, and polymerization that assume a structure resembling a cupped “right hand”. The NSP7-NSP8 heterodimer binds to the index finger loop and may facilitates the interaction of NSP12 with additional components of the RNA synthesis machinery. The second NSP8 molecule binds close to the RNA template-binding channel."	comment:"NCBI Blast gives partial match to NC_045512.2 [29831-29870]  (SARS2 complete genome)  for residues 1-40."	figure legend:Figure S1B|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/08/18	2020/08/24	-	-	-	false	-	sufficient binding region:?-?	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0DTD1-PRO_0000449625	uniprotkb:P0DTD1-PRO_0000449626	intact:EBI-25475871	intact:EBI-25475874	psi-mi:p0dtd1-pro_0000449625(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:p0dtd1-pro_0000449626(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0071"(molecular sieving)	Chen et al. (2020)	pubmed:32783916|imex:IM-28291	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25817172|imex:IM-28291-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	chain-seq-start:3860|chain-seq-end:3942	chain-seq-start:3943|chain-seq-end:4140	figure legend:Figure S1B|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/08/18	2020/09/16	rogid:3AF/ThDr7adqPPYFWsiWQE2FVyY2697049	rogid:Bxev1BKtZTT1Fyf+lpsPapVosnc2697049	rigid:TdMBDIvOL7GW+tgRvY3boc7Q6tU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0DTD1-PRO_0000449625	uniprotkb:P0DTD1-PRO_0000449629	intact:EBI-25475871	intact:EBI-25475885	psi-mi:p0dtd1-pro_0000449625(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:p0dtd1-pro_0000449629(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0071"(molecular sieving)	Chen et al. (2020)	pubmed:32783916|imex:IM-28291	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25817172|imex:IM-28291-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	chain-seq-start:3860|chain-seq-end:3942	chain-seq-start:4393|chain-seq-end:5324	figure legend:Figure S1B|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/08/18	2020/09/16	rogid:3AF/ThDr7adqPPYFWsiWQE2FVyY2697049	rogid:kbHtZYssQIRdvLv8DVwmVD7XSW02697049	rigid:TdMBDIvOL7GW+tgRvY3boc7Q6tU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
wwpdb:7ctt	intact:EBI-25816901	intact:EBI-25564960|wwpdb:6xqb|emdb:EMD-22288|wwpdb:6M71|wwpdb:7btf|emdb:EMD-30178|emdb:EMD-30127|intenz:2.7.7.48|wwpdb:7bv2|emdb:EMD-30210|wwpdb:7bv1|emdb:EMD-30209|wwpdb:6x2g|wwpdb:7bw4|emdb:EMD-30226|wwpdb:7l1f|emdb:EMD-23109|wwpdb:6yyt|emdb:EMD-11007|wwpdb:7c2k|emdb:EMD-30275|wwpdb:7bzf|emdb:EMD-30252|reactome:R-COV-9691364|wwpdb:7aap|emdb:EMD-11692|wwpdb:7d4f|emdb:EMD-30572|emdb:EMD-23009|wwpdb:7krp|wwpdb:7b3b|emdb:EMD-11993|wwpdb:7b3c|emdb:EMD-11994|wwpdb:7b3d|emdb:EMD-11995|rhea:"RHEA:21248"|wwpdb:7ozv|emdb:EMD-13138|wwpdb:7ozu|emdb:EMD-13135|wwpdb:7oyg|emdb:EMD-13116	-	psi-mi:nsp7-nsp8-nsp12_sars2(display_short)|psi-mi:7ctt(display_long)|intact:SARS-CoV-2 polymerase complex(complex recommended name)|intact:"NSP7:2xNSP8:NSP12"(complex systematic name)|intact:replication-transcription complex(complex synonym)|intact:replication and transcription complex(complex synonym)|intact:RTC(complex synonym)|intact:central RTC(complex synonym)|intact:C-RTC(complex synonym)|intact:holo-RdRp complex(complex synonym)|intact:holo-RNA-dependent RNA polymerase complex(complex synonym)	psi-mi:product-rna(display_short)|psi-mi:EBI-25816901(display_long)	psi-mi:"MI:0700"(rna directed rna polymerase assay)	Chen et al. (2020)	pubmed:32783916|imex:IM-28291	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:32630(synthetic construct)|taxid:32630(synthetic construct)	psi-mi:"MI:0987"(rna strand elongation)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25817197|imex:IM-28291-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:2359"(ds rna)	intact:EBI-25506373(exp-evidence)|pubmed:32277040(see-also)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0039694"(viral RNA genome replication)|efo:"EFO:0000694"(see-also)|pubmed:16228002(see-also)|go:"GO:0031381"(viral RNA-directed RNA polymerase complex)|pubmed:19875418(see-also)|pubmed:31138817(see-also)|pubmed:31987001(see-also)|pubmed:18255185(see-also)|complex portal:CPX-5742(complex-primary)|pubmed:32015508(see-also)|evidence ontology:"ECO:0000353"	-	go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)	curated-complex:"RNA-directed 5'-3' RNA polymerase of the SARS-CoV-2 coronavirus which consists of the main polymerase protein NSP12 and a stoichiometric variant of the primase complex (CPX-5690). Extends partially double-stranded RNA templates and is probably also required for transcription initiation, though the mechanism for this has yet to be determined. Complex formation enhances dsRNA binding of the individual protomers."|complex-assembly:Heterotetramer|disease:"Severe acute respiratory syndrome (SARS) [EFO:0000694]: A viral respiratory infection caused by the SARS coronavirus. It is transmitted through close person-to-person contact. It is manifested with high fever, headache, dry cough and myalgias. It may progress to pneumonia and cause death."|complex-properties:"Primase complex without polymerase has a different stoichiometry (8:8). NSP12 possesses conserved motifs involved in template binding, NTP binding, and polymerization that assume a structure resembling a cupped “right hand”. The NSP7-NSP8 heterodimer binds to the index finger loop and may facilitates the interaction of NSP12 with additional components of the RNA synthesis machinery. The second NSP8 molecule binds close to the RNA template-binding channel."	comment:"NCBI and Ensembl (BLAT/BLAST) give NO matches.   (UCSC BLAT gives a partial match to  chr14:70927135-70927153)"	figure legend:Figure S1C|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/08/18	2020/08/24	-	-	-	false	-	sufficient binding region:16-35	1	1	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
wwpdb:7ctt	intact:EBI-25816965	intact:EBI-25564960|wwpdb:6xqb|emdb:EMD-22288|wwpdb:6M71|wwpdb:7btf|emdb:EMD-30178|emdb:EMD-30127|intenz:2.7.7.48|wwpdb:7bv2|emdb:EMD-30210|wwpdb:7bv1|emdb:EMD-30209|wwpdb:6x2g|wwpdb:7bw4|emdb:EMD-30226|wwpdb:7l1f|emdb:EMD-23109|wwpdb:6yyt|emdb:EMD-11007|wwpdb:7c2k|emdb:EMD-30275|wwpdb:7bzf|emdb:EMD-30252|reactome:R-COV-9691364|wwpdb:7aap|emdb:EMD-11692|wwpdb:7d4f|emdb:EMD-30572|emdb:EMD-23009|wwpdb:7krp|wwpdb:7b3b|emdb:EMD-11993|wwpdb:7b3c|emdb:EMD-11994|wwpdb:7b3d|emdb:EMD-11995|rhea:"RHEA:21248"|wwpdb:7ozv|emdb:EMD-13138|wwpdb:7ozu|emdb:EMD-13135|wwpdb:7oyg|emdb:EMD-13116	-	psi-mi:nsp7-nsp8-nsp12_sars2(display_short)|psi-mi:7ctt(display_long)|intact:SARS-CoV-2 polymerase complex(complex recommended name)|intact:"NSP7:2xNSP8:NSP12"(complex systematic name)|intact:replication-transcription complex(complex synonym)|intact:replication and transcription complex(complex synonym)|intact:RTC(complex synonym)|intact:central RTC(complex synonym)|intact:C-RTC(complex synonym)|intact:holo-RdRp complex(complex synonym)|intact:holo-RNA-dependent RNA polymerase complex(complex synonym)	psi-mi:template-rna(display_short)|psi-mi:EBI-25816965(display_long)	psi-mi:"MI:0700"(rna directed rna polymerase assay)	Chen et al. (2020)	pubmed:32783916|imex:IM-28291	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:32630(synthetic construct)|taxid:32630(synthetic construct)	psi-mi:"MI:0987"(rna strand elongation)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25817197|imex:IM-28291-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0318"(nucleic acid)	intact:EBI-25506373(exp-evidence)|pubmed:32277040(see-also)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0039694"(viral RNA genome replication)|efo:"EFO:0000694"(see-also)|pubmed:16228002(see-also)|go:"GO:0031381"(viral RNA-directed RNA polymerase complex)|pubmed:19875418(see-also)|pubmed:31138817(see-also)|pubmed:31987001(see-also)|pubmed:18255185(see-also)|complex portal:CPX-5742(complex-primary)|pubmed:32015508(see-also)|evidence ontology:"ECO:0000353"	-	go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)	curated-complex:"RNA-directed 5'-3' RNA polymerase of the SARS-CoV-2 coronavirus which consists of the main polymerase protein NSP12 and a stoichiometric variant of the primase complex (CPX-5690). Extends partially double-stranded RNA templates and is probably also required for transcription initiation, though the mechanism for this has yet to be determined. Complex formation enhances dsRNA binding of the individual protomers."|complex-assembly:Heterotetramer|disease:"Severe acute respiratory syndrome (SARS) [EFO:0000694]: A viral respiratory infection caused by the SARS coronavirus. It is transmitted through close person-to-person contact. It is manifested with high fever, headache, dry cough and myalgias. It may progress to pneumonia and cause death."|complex-properties:"Primase complex without polymerase has a different stoichiometry (8:8). NSP12 possesses conserved motifs involved in template binding, NTP binding, and polymerization that assume a structure resembling a cupped “right hand”. The NSP7-NSP8 heterodimer binds to the index finger loop and may facilitates the interaction of NSP12 with additional components of the RNA synthesis machinery. The second NSP8 molecule binds close to the RNA template-binding channel."	comment:"NCBI Blast gives partial match to NC_045512.2 [29831-29870]  (SARS2 complete genome)  for residues 1-40."	figure legend:Figure S1C|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/08/18	2020/08/24	-	-	-	false	-	sufficient binding region:1-40	1	1	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
chebi:"CHEBI:15422"	uniprotkb:P0DTD1-PRO_0000449630	intact:EBI-1108845|chebi:"CHEBI:40938"|chebi:"CHEBI:10841"|chebi:"CHEBI:10789"|chebi:"CHEBI:2359"|chebi:"CHEBI:13236"|chebi:"CHEBI:22249"	intact:EBI-25475888	psi-mi:atp(display_short)|psi-mi:"CHEBI:15422"(display_long)|intact:Adenosine 5'-triphosphate(synonym)|intact:Adenosine triphosphate(synonym)|intact:ADENOSINE-5'-TRIPHOSPHATE(synonym)|intact:Adephos(synonym)|intact:Adetol(synonym)|intact:Adynol(synonym)|intact:Atipi(synonym)|intact:ATP(synonym)|intact:Atriphos(synonym)|intact:Cardenosine(synonym)|intact:Fosfobion(synonym)|intact:Glucobasin(synonym)|intact:H4atp(synonym)|intact:Myotriphos(synonym)|intact:Triadenyl(synonym)|intact:Triphosphaden(synonym)|intact:"adenosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:p0dtd1-pro_0000449630(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0880"(atpase assay)	Chen et al. (2020)	pubmed:32783916|imex:IM-28291	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0882"(atpase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25817315|imex:IM-28291-17	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	go:"GO:0016887"(ATP hydrolysis activity)	-	chain-seq-start:5325|chain-seq-end:5925	figure legend:Supp. figure 2 A/B|comment:The ATPase activity of nsp13 was maintained within the complex.  There appears to be no significant differences for Kcat and Km values for Nsp13 alone, and with RNA, and /or Nsp 7+8 +12.  Kcat and Km values stated here are the average values from Figure S2A and S2b for Nsp13 alone.|comment:Kcat and Km values stated here are the average values from Figure S2A and S2b for Nsp13 alone.  There are no major  changes for kinetic parameters  in the other mixes tested.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kcat:15.8x10^1(second -1)|km:4.25x10^-6(molar)	2020/08/18	2020/08/24	-	rogid:F98KM8XJ6ElyhUel43fFsarYA3g2697049	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:49464"	chebi:"CHEBI:15422"	intact:EBI-6379710	intact:EBI-1108845|chebi:"CHEBI:40938"|chebi:"CHEBI:10841"|chebi:"CHEBI:10789"|chebi:"CHEBI:2359"|chebi:"CHEBI:13236"|chebi:"CHEBI:22249"	psi-mi:aluminium trifluoride(display_short)|psi-mi:"CHEBI:49464"(display_long)	psi-mi:atp(display_short)|psi-mi:"CHEBI:15422"(display_long)|intact:Adenosine 5'-triphosphate(synonym)|intact:Adenosine triphosphate(synonym)|intact:ADENOSINE-5'-TRIPHOSPHATE(synonym)|intact:Adephos(synonym)|intact:Adetol(synonym)|intact:Adynol(synonym)|intact:Atipi(synonym)|intact:ATP(synonym)|intact:Atriphos(synonym)|intact:Cardenosine(synonym)|intact:Fosfobion(synonym)|intact:Glucobasin(synonym)|intact:H4atp(synonym)|intact:Myotriphos(synonym)|intact:Triadenyl(synonym)|intact:Triphosphaden(synonym)|intact:"adenosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:"MI:0880"(atpase assay)	Chen et al. (2020)	pubmed:32783916|imex:IM-28291	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0882"(atpase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25817333|imex:IM-28291-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	go:"GO:0016887"(ATP hydrolysis activity)	-	-	figure legend:Supp. figure 2 C|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:85.4x10^-6(molar)	2020/08/18	2020/08/24	-	-	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:49464"	uniprotkb:P0DTD1-PRO_0000449630	intact:EBI-6379710	intact:EBI-25475888	psi-mi:aluminium trifluoride(display_short)|psi-mi:"CHEBI:49464"(display_long)	psi-mi:p0dtd1-pro_0000449630(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0880"(atpase assay)	Chen et al. (2020)	pubmed:32783916|imex:IM-28291	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0882"(atpase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25817333|imex:IM-28291-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	go:"GO:0016887"(ATP hydrolysis activity)	-	chain-seq-start:5325|chain-seq-end:5925	figure legend:Supp. figure 2 C|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:85.4x10^-6(molar)	2020/08/18	2020/08/24	-	rogid:F98KM8XJ6ElyhUel43fFsarYA3g2697049	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)