#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P0DTD1-PRO_0000449623	uniprotkb:P0DTD1-PRO_0000449623	intact:EBI-25475864	intact:EBI-25475864	psi-mi:p0dtd1-pro_0000449623(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:p0dtd1-pro_0000449623(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:1311"(differential scanning calorimetry)	Abian et al. (2020)	pubmed:32745548|imex:IM-28239	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25767494|imex:IM-28239-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	go:"GO:0051260"(protein homooligomerization)	chain-seq-start:3264|chain-seq-end:3569	chain-seq-start:3264|chain-seq-end:3569	figure legend:3, S2|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/08/04	2020/08/05	rogid:9u1TJXDTORfCyqj2bv2TlDMZ65c2697049	rogid:9u1TJXDTORfCyqj2bv2TlDMZ65c2697049	rigid:qDWLFEPEN/R73In4P9Oyse2HGW8	false	his tag:c-c|tag:n-n	his tag:c-c|tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0DTD1-PRO_0000449623	intact:EBI-25766888	intact:EBI-25475864	-	psi-mi:p0dtd1-pro_0000449623(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:peptide substrate(display_short)|psi-mi:EBI-25766888(display_long)	psi-mi:"MI:0435"(protease assay)	Abian et al. (2020)	pubmed:32745548|imex:IM-28239	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25772245|imex:IM-28239-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	uniprotkb:P0C6U8(see-also)	-	chain-seq-start:3264|chain-seq-end:3569	-	figure legend:6|comment:"Apparent inhibition constant (Ki  = 21 μM). The \"intrinsic inhibition constant\" (Ki = 9.6 μM) is substrate concentration-independent and based on the assumption that the inhibitor acts through a purely competitive mechanism binding directly to the active site."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ki:21.0x10^-6(molar)	2020/08/04	2020/08/06	rogid:9u1TJXDTORfCyqj2bv2TlDMZ65c2697049	rogid:5paWG8TKpS+Vdd4uWaMMBd0QUBk-2	-	false	his tag:c-c|tag:n-n	fluorophore:c-c|dye label:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16243"	uniprotkb:P0DTD1-PRO_0000449623	intact:EBI-25766955|chebi:"CHEBI:45280"|chebi:"CHEBI:8696"|chebi:"CHEBI:14991"|chebi:"CHEBI:11704"|chebi:"CHEBI:26472"	intact:EBI-25475864	psi-mi:quercetin(display_short)|psi-mi:"CHEBI:16243"(display_long)|intact:"2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one"(synonym)|intact:3,3',4',5,7-pentahydroxyflavone(synonym)|intact:3,5,7,3',4'-Pentahydroxyflavone(synonym)|intact:3,5,7,3',4'-PENTAHYDROXYFLAVONE(synonym)|intact:Quercetin(synonym)|intact:sophoretin(synonym)|intact:xanthaurine(synonym)|intact:"2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one"(iupac name)	psi-mi:p0dtd1-pro_0000449623(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0435"(protease assay)	Abian et al. (2020)	pubmed:32745548|imex:IM-28239	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25772245|imex:IM-28239-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	-	chain-seq-start:3264|chain-seq-end:3569	figure legend:6|comment:"Apparent inhibition constant (Ki  = 21 μM). The \"intrinsic inhibition constant\" (Ki = 9.6 μM) is substrate concentration-independent and based on the assumption that the inhibitor acts through a purely competitive mechanism binding directly to the active site."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ki:21.0x10^-6(molar)	2020/08/04	2020/08/06	-	rogid:9u1TJXDTORfCyqj2bv2TlDMZ65c2697049	-	false	-	his tag:c-c|tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-25766888	uniprotkb:P0DTD1-PRO_0000449623	-	intact:EBI-25475864	psi-mi:peptide substrate(display_short)|psi-mi:EBI-25766888(display_long)	psi-mi:p0dtd1-pro_0000449623(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0435"(protease assay)	Abian et al. (2020)	pubmed:32745548|imex:IM-28239	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25772325|imex:IM-28239-7	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	uniprotkb:P0C6U8(see-also)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	-	chain-seq-start:3264|chain-seq-end:3569	figure legend:4, S3.|kinetic_conditions:pH =8.0|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	km:11.0x10^-6(molar)	2020/08/04	2020/08/06	rogid:5paWG8TKpS+Vdd4uWaMMBd0QUBk-2	rogid:9u1TJXDTORfCyqj2bv2TlDMZ65c2697049	rigid:AjyLX86/Ie8uYIiN31Zn33cnUmk	false	fluorophore:c-c|dye label:n-n	his tag:c-c|tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0DTD1-PRO_0000449623	intact:EBI-25766888	intact:EBI-25475864	-	psi-mi:p0dtd1-pro_0000449623(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:peptide substrate(display_short)|psi-mi:EBI-25766888(display_long)	psi-mi:"MI:1235"(thermal shift binding)	Abian et al. (2020)	pubmed:32745548|imex:IM-28239	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25772293|imex:IM-28239-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	uniprotkb:P0C6U8(see-also)	-	chain-seq-start:3264|chain-seq-end:3569	-	figure legend:7|comment:Quercetin  altered the thermal stability of 3CLpro causing  destabilization.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/08/04	2020/08/06	rogid:9u1TJXDTORfCyqj2bv2TlDMZ65c2697049	rogid:5paWG8TKpS+Vdd4uWaMMBd0QUBk-2	-	false	his tag:c-c|tag:n-n	fluorophore:c-c|dye label:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16243"	uniprotkb:P0DTD1-PRO_0000449623	intact:EBI-25766955|chebi:"CHEBI:45280"|chebi:"CHEBI:8696"|chebi:"CHEBI:14991"|chebi:"CHEBI:11704"|chebi:"CHEBI:26472"	intact:EBI-25475864	psi-mi:quercetin(display_short)|psi-mi:"CHEBI:16243"(display_long)|intact:"2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one"(synonym)|intact:3,3',4',5,7-pentahydroxyflavone(synonym)|intact:3,5,7,3',4'-Pentahydroxyflavone(synonym)|intact:3,5,7,3',4'-PENTAHYDROXYFLAVONE(synonym)|intact:Quercetin(synonym)|intact:sophoretin(synonym)|intact:xanthaurine(synonym)|intact:"2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one"(iupac name)	psi-mi:p0dtd1-pro_0000449623(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:1235"(thermal shift binding)	Abian et al. (2020)	pubmed:32745548|imex:IM-28239	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25772293|imex:IM-28239-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	-	chain-seq-start:3264|chain-seq-end:3569	figure legend:7|comment:Quercetin  altered the thermal stability of 3CLpro causing  destabilization.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/08/04	2020/08/06	-	rogid:9u1TJXDTORfCyqj2bv2TlDMZ65c2697049	-	false	-	his tag:c-c|tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0DTD1-PRO_0000449623	intact:EBI-25766888	intact:EBI-25475864	-	psi-mi:p0dtd1-pro_0000449623(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:peptide substrate(display_short)|psi-mi:EBI-25766888(display_long)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Abian et al. (2020)	pubmed:32745548|imex:IM-28239	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25772355|imex:IM-28239-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	uniprotkb:P0C6U8(see-also)	-	chain-seq-start:3264|chain-seq-end:3569	-	figure legend:8|kinetic_conditions:Quercetin interacts with 3CLpro with a dissociation constant of 2.7 uM in the absence of NaCl, and a dissociation constant of 10 uM in the presence of NaCl 150 mM.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.7x10^-6(molar)|kd:10.0x10^-6(molar)	2020/08/04	2020/08/06	rogid:9u1TJXDTORfCyqj2bv2TlDMZ65c2697049	rogid:5paWG8TKpS+Vdd4uWaMMBd0QUBk-2	-	false	his tag:c-c|tag:n-n	fluorophore:c-c|dye label:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16243"	uniprotkb:P0DTD1-PRO_0000449623	intact:EBI-25766955|chebi:"CHEBI:45280"|chebi:"CHEBI:8696"|chebi:"CHEBI:14991"|chebi:"CHEBI:11704"|chebi:"CHEBI:26472"	intact:EBI-25475864	psi-mi:quercetin(display_short)|psi-mi:"CHEBI:16243"(display_long)|intact:"2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one"(synonym)|intact:3,3',4',5,7-pentahydroxyflavone(synonym)|intact:3,5,7,3',4'-Pentahydroxyflavone(synonym)|intact:3,5,7,3',4'-PENTAHYDROXYFLAVONE(synonym)|intact:Quercetin(synonym)|intact:sophoretin(synonym)|intact:xanthaurine(synonym)|intact:"2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one"(iupac name)	psi-mi:p0dtd1-pro_0000449623(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Abian et al. (2020)	pubmed:32745548|imex:IM-28239	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25772355|imex:IM-28239-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	-	chain-seq-start:3264|chain-seq-end:3569	figure legend:8|kinetic_conditions:Quercetin interacts with 3CLpro with a dissociation constant of 2.7 uM in the absence of NaCl, and a dissociation constant of 10 uM in the presence of NaCl 150 mM.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.7x10^-6(molar)|kd:10.0x10^-6(molar)	2020/08/04	2020/08/06	-	rogid:9u1TJXDTORfCyqj2bv2TlDMZ65c2697049	-	false	-	his tag:c-c|tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0DTD1-PRO_0000449623	uniprotkb:P0DTD1-PRO_0000449623	intact:EBI-25475864	intact:EBI-25475864	psi-mi:p0dtd1-pro_0000449623(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:p0dtd1-pro_0000449623(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0038"(dynamic light scattering)	Abian et al. (2020)	pubmed:32745548|imex:IM-28239	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25774634|imex:IM-28239-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	go:"GO:0051260"(protein homooligomerization)	chain-seq-start:3264|chain-seq-end:3569	chain-seq-start:3264|chain-seq-end:3569	figure legend:S4|comment:Hydrodynamic radius measurements by dynamic light scattering showed a predominant population of particles compatible with dimeric 3CLpro .|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/08/04	2020/08/10	rogid:9u1TJXDTORfCyqj2bv2TlDMZ65c2697049	rogid:9u1TJXDTORfCyqj2bv2TlDMZ65c2697049	rigid:x8zjUh7Hu9Bss8jPnZX6S6ox/y8	false	his tag:c-c|tag:n-n	his tag:c-c|tag:n-n	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)