#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9UBS5	uniprotkb:O75899	intact:EBI-724156|uniprotkb:Q71SG6|ensembl:ENSP00000366233|ensembl:ENSP00000373034|ensembl:ENSP00000373134|ensembl:ENSP00000388035|ensembl:ENSP00000406066|ensembl:ENSP00000411286|ensembl:ENSP00000448999|uniprotkb:Q9UQQ0|uniprotkb:O95375|uniprotkb:O95468|uniprotkb:O95975|uniprotkb:O96022|uniprotkb:Q86W60|uniprotkb:B0UXY7|uniprotkb:Q5STL4|uniprotkb:Q5SUJ8|uniprotkb:Q5SUL3	intact:EBI-715469|uniprotkb:O75974|uniprotkb:O75975|uniprotkb:Q5VXZ2|uniprotkb:Q8WX04|uniprotkb:Q9P1R2|uniprotkb:Q9UNR1|uniprotkb:Q9UNS9|ensembl:ENSP00000259455	psi-mi:gabr1_human(display_long)|uniprotkb:GABBR1(gene name)|psi-mi:GABBR1(display_short)|uniprotkb:GPRC3A(gene name synonym)	psi-mi:gabr2_human(display_long)|uniprotkb:G-protein coupled receptor 51(gene name synonym)|uniprotkb:HG20(gene name synonym)|uniprotkb:GABBR2(gene name)|psi-mi:GABBR2(display_short)|uniprotkb:GPR51(gene name synonym)|uniprotkb:GPRC3B(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Shaye et al. (2020)	imex:IM-28198|pubmed:32555460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-25759227|imex:IM-28198-1|wwpdb:6VJM|wwpdb:6UOA|wwpdb:6UO9|wwpdb:6UO8|emdb:EMD-21219|emdb:EMD-20824|emdb:EMD-20823|emdb:EMD-20822	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001461.1|refseq:NP_068703.1|refseq:NP_068704.2|refseq:NP_001305982.1|ensembl:ENSG00000204681(gene)|ensembl:ENSG00000206466(gene)|ensembl:ENSG00000206511(gene)|ensembl:ENSG00000232569(gene)|ensembl:ENSG00000232632(gene)|ensembl:ENSG00000237112(gene)|ensembl:ENST00000377034(transcript)|ensembl:ENST00000383542(transcript)|ensembl:ENST00000383638(transcript)|ensembl:ENST00000423604(transcript)|ensembl:ENST00000425097(transcript)|ensembl:ENST00000439457(transcript)|ensembl:ENST00000546913(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004965"(G protein-coupled GABA receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0030425"(dendrite)|go:"GO:0038039"(G protein-coupled receptor heterodimeric complex)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099579"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0150099"(neuron-glial cell signaling)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR002455(GPCR, family 3, gamma-aminobutyric acid receptor, type B)|interpro:IPR002456(GPCR, family 3, gamma-aminobutyric acid receptor, type B1)|interpro:IPR017978|interpro:IPR028082|interpro:IPR035976|mint:Q9UBS5|rcsb pdb:4MQE|rcsb pdb:4MQF|rcsb pdb:4MR7|rcsb pdb:4MR8|rcsb pdb:4MR9|rcsb pdb:4MRM|rcsb pdb:4MS1|rcsb pdb:4MS3|rcsb pdb:4MS4|rcsb pdb:4PAS|rcsb pdb:6HKC|rcsb pdb:6UO8|rcsb pdb:6UO9|go:"GO:0005887"(integral component of plasma membrane)|rcsb pdb:6UOA|rcsb pdb:6VJM|rcsb pdb:6W2X|rcsb pdb:6W2Y|rcsb pdb:6WIV|rcsb pdb:7C7Q|rcsb pdb:7C7S|rcsb pdb:7CA3|rcsb pdb:7CA5|rcsb pdb:7CUM|rcsb pdb:7EB2|reactome:R-HSA-1296041|reactome:R-HSA-418594|reactome:R-HSA-420499|reactome:R-HSA-977444|reactome:R-HSA-997272|dip:DIP-38394N	refseq:NP_005449.5|ensembl:ENSG00000136928(gene)|ensembl:ENST00000259455(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004965"(G protein-coupled GABA receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0038039"(G protein-coupled receptor heterodimeric complex)|go:"GO:0043005"(neuron projection)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0150099"(neuron-glial cell signaling)|go:"GO:1902710"(GABA receptor complex)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR002455(GPCR, family 3, gamma-aminobutyric acid receptor, type B)|interpro:IPR002457(GPCR, family 3, gamma-aminobutyric acid receptor, type B2)|interpro:IPR017978|interpro:IPR017979|interpro:IPR028082|interpro:IPR041689|mint:O75899|rcsb pdb:4F11|rcsb pdb:4F12|rcsb pdb:4MQE|rcsb pdb:4MQF|rcsb pdb:4MR7|rcsb pdb:4MR8|rcsb pdb:4MR9|rcsb pdb:4MRM|rcsb pdb:4MS1|rcsb pdb:4MS3|rcsb pdb:4MS4|rcsb pdb:4PAS|rcsb pdb:6M8R|rcsb pdb:6OCP|rcsb pdb:6UO8|rcsb pdb:6UO9|rcsb pdb:6UOA|rcsb pdb:6VJM|rcsb pdb:6W2X|rcsb pdb:6WIV|rcsb pdb:7C7Q|rcsb pdb:7C7S|rcsb pdb:7CA3|rcsb pdb:7CA5|rcsb pdb:7CUM|rcsb pdb:7EB2|reactome:R-HSA-1296041|reactome:R-HSA-418594|reactome:R-HSA-420499|reactome:R-HSA-977444|reactome:R-HSA-997272|dip:DIP-42851N	-	-	-	figure legend:Fig 1, Ext Data Tab 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells)	-	2020/07/18	2020/07/18	rogid:HC9ZjJABHiocFy0LZoIb/oa0D7E9606	rogid:vJ8ADZ7mdufBs4z/z0Zy4TzN3Sw9606	rigid:PXxR8P/Zzzk4q4c21IEQ22E4E4M	false	binding-associated region:165-920	binding-associated region:42-821	1	1	psi-mi:"MI:0823"(predetermined feature)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0823"(predetermined feature)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:Q9UBS5	uniprotkb:O75899	intact:EBI-724156|uniprotkb:Q71SG6|ensembl:ENSP00000366233|ensembl:ENSP00000373034|ensembl:ENSP00000373134|ensembl:ENSP00000388035|ensembl:ENSP00000406066|ensembl:ENSP00000411286|ensembl:ENSP00000448999|uniprotkb:Q9UQQ0|uniprotkb:O95375|uniprotkb:O95468|uniprotkb:O95975|uniprotkb:O96022|uniprotkb:Q86W60|uniprotkb:B0UXY7|uniprotkb:Q5STL4|uniprotkb:Q5SUJ8|uniprotkb:Q5SUL3	intact:EBI-715469|uniprotkb:O75974|uniprotkb:O75975|uniprotkb:Q5VXZ2|uniprotkb:Q8WX04|uniprotkb:Q9P1R2|uniprotkb:Q9UNR1|uniprotkb:Q9UNS9|ensembl:ENSP00000259455	psi-mi:gabr1_human(display_long)|uniprotkb:GABBR1(gene name)|psi-mi:GABBR1(display_short)|uniprotkb:GPRC3A(gene name synonym)	psi-mi:gabr2_human(display_long)|uniprotkb:G-protein coupled receptor 51(gene name synonym)|uniprotkb:HG20(gene name synonym)|uniprotkb:GABBR2(gene name)|psi-mi:GABBR2(display_short)|uniprotkb:GPR51(gene name synonym)|uniprotkb:GPRC3B(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Shaye et al. (2020)	imex:IM-28198|pubmed:32555460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-25759250|imex:IM-28198-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001461.1|refseq:NP_068703.1|refseq:NP_068704.2|refseq:NP_001305982.1|ensembl:ENSG00000204681(gene)|ensembl:ENSG00000206466(gene)|ensembl:ENSG00000206511(gene)|ensembl:ENSG00000232569(gene)|ensembl:ENSG00000232632(gene)|ensembl:ENSG00000237112(gene)|ensembl:ENST00000377034(transcript)|ensembl:ENST00000383542(transcript)|ensembl:ENST00000383638(transcript)|ensembl:ENST00000423604(transcript)|ensembl:ENST00000425097(transcript)|ensembl:ENST00000439457(transcript)|ensembl:ENST00000546913(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004965"(G protein-coupled GABA receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0030425"(dendrite)|go:"GO:0038039"(G protein-coupled receptor heterodimeric complex)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099579"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0150099"(neuron-glial cell signaling)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR002455(GPCR, family 3, gamma-aminobutyric acid receptor, type B)|interpro:IPR002456(GPCR, family 3, gamma-aminobutyric acid receptor, type B1)|interpro:IPR017978|interpro:IPR028082|interpro:IPR035976|mint:Q9UBS5|rcsb pdb:4MQE|rcsb pdb:4MQF|rcsb pdb:4MR7|rcsb pdb:4MR8|rcsb pdb:4MR9|rcsb pdb:4MRM|rcsb pdb:4MS1|rcsb pdb:4MS3|rcsb pdb:4MS4|rcsb pdb:4PAS|rcsb pdb:6HKC|rcsb pdb:6UO8|rcsb pdb:6UO9|go:"GO:0005887"(integral component of plasma membrane)|rcsb pdb:6UOA|rcsb pdb:6VJM|rcsb pdb:6W2X|rcsb pdb:6W2Y|rcsb pdb:6WIV|rcsb pdb:7C7Q|rcsb pdb:7C7S|rcsb pdb:7CA3|rcsb pdb:7CA5|rcsb pdb:7CUM|rcsb pdb:7EB2|reactome:R-HSA-1296041|reactome:R-HSA-418594|reactome:R-HSA-420499|reactome:R-HSA-977444|reactome:R-HSA-997272|dip:DIP-38394N	refseq:NP_005449.5|ensembl:ENSG00000136928(gene)|ensembl:ENST00000259455(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004965"(G protein-coupled GABA receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0038039"(G protein-coupled receptor heterodimeric complex)|go:"GO:0043005"(neuron projection)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0150099"(neuron-glial cell signaling)|go:"GO:1902710"(GABA receptor complex)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR002455(GPCR, family 3, gamma-aminobutyric acid receptor, type B)|interpro:IPR002457(GPCR, family 3, gamma-aminobutyric acid receptor, type B2)|interpro:IPR017978|interpro:IPR017979|interpro:IPR028082|interpro:IPR041689|mint:O75899|rcsb pdb:4F11|rcsb pdb:4F12|rcsb pdb:4MQE|rcsb pdb:4MQF|rcsb pdb:4MR7|rcsb pdb:4MR8|rcsb pdb:4MR9|rcsb pdb:4MRM|rcsb pdb:4MS1|rcsb pdb:4MS3|rcsb pdb:4MS4|rcsb pdb:4PAS|rcsb pdb:6M8R|rcsb pdb:6OCP|rcsb pdb:6UO8|rcsb pdb:6UO9|rcsb pdb:6UOA|rcsb pdb:6VJM|rcsb pdb:6W2X|rcsb pdb:6WIV|rcsb pdb:7C7Q|rcsb pdb:7C7S|rcsb pdb:7CA3|rcsb pdb:7CA5|rcsb pdb:7CUM|rcsb pdb:7EB2|reactome:R-HSA-1296041|reactome:R-HSA-418594|reactome:R-HSA-420499|reactome:R-HSA-977444|reactome:R-HSA-997272|dip:DIP-42851N	-	-	-	figure legend:Ext Data Fig 1e-f|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells)	-	2020/07/18	2020/07/18	rogid:HC9ZjJABHiocFy0LZoIb/oa0D7E9606	rogid:vJ8ADZ7mdufBs4z/z0Zy4TzN3Sw9606	rigid:PXxR8P/Zzzk4q4c21IEQ22E4E4M	false	binding-associated region:165-920	binding-associated region:42-821	1	1	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)