#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P10997	uniprotkb:P10997	intact:EBI-8526679|uniprotkb:Q14598|intact:MINT-8074874|uniprotkb:Q0ZD87|ensembl:ENSP00000240652|ensembl:ENSP00000437357	intact:EBI-8526679|uniprotkb:Q14598|intact:MINT-8074874|uniprotkb:Q0ZD87|ensembl:ENSP00000240652|ensembl:ENSP00000437357	psi-mi:iapp_human(display_long)|uniprotkb:IAPP(gene name)|psi-mi:IAPP(display_short)|uniprotkb:Amylin(gene name synonym)|uniprotkb:Diabetes-associated peptide(gene name synonym)|uniprotkb:Insulinoma amyloid peptide(gene name synonym)	psi-mi:iapp_human(display_long)|uniprotkb:IAPP(gene name)|psi-mi:IAPP(display_short)|uniprotkb:Amylin(gene name synonym)|uniprotkb:Diabetes-associated peptide(gene name synonym)|uniprotkb:Insulinoma amyloid peptide(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Röder et al. (2020)	pubmed:32541895|imex:IM-28568	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26315890|wwpdb:6Y1A|emdb:EMD-10669|emdb:EMD-10670|emdb:EMD-10671|imex:IM-28568-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000406.1|refseq:NP_001316130.1|dip:DIP-29913N|ensembl:ENSG00000121351(gene)|ensembl:ENST00000240652(transcript)|ensembl:ENST00000539393(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010823"(negative regulation of mitochondrion organization)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016234"(inclusion body)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031648"(protein destabilization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097647"(amylin receptor signaling pathway)|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990000"(amyloid fibril formation)|interpro:IPR000443(Islet amyloid polypeptide)|interpro:IPR001693(Calcitonin-like)|interpro:IPR018360|interpro:IPR021116|interpro:IPR021117|rcsb pdb:1KUW|rcsb pdb:2G48|rcsb pdb:2KB8|rcsb pdb:2L86|rcsb pdb:3DG1|rcsb pdb:3FPO|rcsb pdb:3FR1|rcsb pdb:3FTH|rcsb pdb:3FTK|rcsb pdb:3FTL|rcsb pdb:3FTR|rcsb pdb:3G7V|rcsb pdb:3G7W|rcsb pdb:3HGZ|rcsb pdb:5K5G|rcsb pdb:5KNZ|rcsb pdb:5KO0|rcsb pdb:5MGQ|rcsb pdb:6UCJ|rcsb pdb:6UCK|rcsb pdb:6VW2|rcsb pdb:6Y1A|rcsb pdb:6ZRF|rcsb pdb:6ZRQ|rcsb pdb:6ZRR|reactome:R-HSA-210745|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|reactome:R-HSA-977225	refseq:NP_000406.1|refseq:NP_001316130.1|dip:DIP-29913N|ensembl:ENSG00000121351(gene)|ensembl:ENST00000240652(transcript)|ensembl:ENST00000539393(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010823"(negative regulation of mitochondrion organization)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016234"(inclusion body)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031648"(protein destabilization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097647"(amylin receptor signaling pathway)|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990000"(amyloid fibril formation)|interpro:IPR000443(Islet amyloid polypeptide)|interpro:IPR001693(Calcitonin-like)|interpro:IPR018360|interpro:IPR021116|interpro:IPR021117|rcsb pdb:1KUW|rcsb pdb:2G48|rcsb pdb:2KB8|rcsb pdb:2L86|rcsb pdb:3DG1|rcsb pdb:3FPO|rcsb pdb:3FR1|rcsb pdb:3FTH|rcsb pdb:3FTK|rcsb pdb:3FTL|rcsb pdb:3FTR|rcsb pdb:3G7V|rcsb pdb:3G7W|rcsb pdb:3HGZ|rcsb pdb:5K5G|rcsb pdb:5KNZ|rcsb pdb:5KO0|rcsb pdb:5MGQ|rcsb pdb:6UCJ|rcsb pdb:6UCK|rcsb pdb:6VW2|rcsb pdb:6Y1A|rcsb pdb:6ZRF|rcsb pdb:6ZRQ|rcsb pdb:6ZRR|reactome:R-HSA-210745|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|reactome:R-HSA-977225	-	"mimix:comment":not sure about the protein origin|comment:mint	"mimix:comment":not sure about the protein origin|comment:mint	figure legend:Fig 1, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/09/18	2020/12/09	rogid:96US2nyXcc+hMG9Y4+Be1pxnJgw9606	rogid:96US2nyXcc+hMG9Y4+Be1pxnJgw9606	rigid:yaSda/zEF7PO2wAvTB22/T+g5KA	false	binding-associated region:34-70	binding-associated region:34-70	16	0	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)