#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B chebi:"CHEBI:17677" uniprotkb:P0DTD1-PRO_0000449630 intact:EBI-9685188|chebi:"CHEBI:3285"|chebi:"CHEBI:41675"|chebi:"CHEBI:23522"|chebi:"CHEBI:13286" intact:EBI-25475888 psi-mi:ctp(display_short)|psi-mi:"CHEBI:17677"(display_long)|intact:5'-CTP(synonym)|intact:CTP(synonym)|intact:Cytidine 5'-triphosphate(synonym)|intact:Cytidine triphosphate(synonym)|intact:CYTIDINE-5'-TRIPHOSPHATE(synonym)|intact:H4ctp(synonym)|intact:"cytidine 5'-(tetrahydrogen triphosphate)"(iupac name) psi-mi:p0dtd1-pro_0000449630(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0879"(nucleoside triphosphatase assay) Shu et al. (2020) pubmed:32500504|imex:IM-28459 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0881"(nucleoside triphosphatase reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26430394|imex:IM-28459-21 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) go:"GO:0017111"(nucleoside-triphosphatase activity) inchi key:PCDQPRRSZKQHHS-XVFCMESISA-N chain-seq-start:5325|chain-seq-end:5925 figure legend:1A|comment:Recombinant SARS-CoV-2 nsp13 could hydrolyze all four types of NTPs, with a preference for ATP and GTP.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/14 2020/10/28 - rogid:F98KM8XJ6ElyhUel43fFsarYA3g2697049 - false - maltose binding protein tag:n-n|sufficient binding region:1-586 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:15713" uniprotkb:P0DTD1-PRO_0000449630 intact:EBI-9685100|chebi:"CHEBI:13510"|chebi:"CHEBI:9850"|chebi:"CHEBI:27233" intact:EBI-25475888 psi-mi:utp(display_short)|psi-mi:"CHEBI:15713"(display_long)|intact:5'-UTP(synonym)|intact:H4utp(synonym)|intact:Uridine 5'-triphosphate(synonym)|intact:uridine 5'-triphosphoric acid(synonym)|intact:Uridine triphosphate(synonym)|intact:UTP(synonym)|intact:"uridine 5'-(tetrahydrogen triphosphate)"(iupac name) psi-mi:p0dtd1-pro_0000449630(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0879"(nucleoside triphosphatase assay) Shu et al. (2020) pubmed:32500504|imex:IM-28459 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0881"(nucleoside triphosphatase reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26430401|imex:IM-28459-1 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) go:"GO:0017111"(nucleoside-triphosphatase activity) inchi key:PGAVKCOVUIYSFO-XVFCMESISA-N chain-seq-start:5325|chain-seq-end:5925 figure legend:1A|comment:Recombinant SARS-CoV-2 nsp13 could hydrolyze all four types of NTPs, with a preference for ATP and GTP.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/14 2020/10/28 - rogid:F98KM8XJ6ElyhUel43fFsarYA3g2697049 - false - maltose binding protein tag:n-n|sufficient binding region:1-586 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:15422" uniprotkb:P0DTD1-PRO_0000449630 intact:EBI-1108845|chebi:"CHEBI:40938"|chebi:"CHEBI:10841"|chebi:"CHEBI:10789"|chebi:"CHEBI:2359"|chebi:"CHEBI:13236"|chebi:"CHEBI:22249" intact:EBI-25475888 psi-mi:atp(display_short)|psi-mi:"CHEBI:15422"(display_long)|intact:Adenosine 5'-triphosphate(synonym)|intact:Adenosine triphosphate(synonym)|intact:ADENOSINE-5'-TRIPHOSPHATE(synonym)|intact:Adephos(synonym)|intact:Adetol(synonym)|intact:Adynol(synonym)|intact:Atipi(synonym)|intact:ATP(synonym)|intact:Atriphos(synonym)|intact:Cardenosine(synonym)|intact:Fosfobion(synonym)|intact:Glucobasin(synonym)|intact:H4atp(synonym)|intact:Myotriphos(synonym)|intact:Triadenyl(synonym)|intact:Triphosphaden(synonym)|intact:"adenosine 5'-(tetrahydrogen triphosphate)"(iupac name) psi-mi:p0dtd1-pro_0000449630(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0880"(atpase assay) Shu et al. (2020) pubmed:32500504|imex:IM-28459 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0882"(atpase reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26430442|imex:IM-28459-3 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) go:"GO:0016887"(ATP hydrolysis activity) - chain-seq-start:5325|chain-seq-end:5925 figure legend:1 A-D, 5A|comment:Optimal ATPase activity was shown in the presence of 2 mmol/L Mg2+.|comment:Recombinant SARS-CoV-2 nsp13 could hydrolyze all four types of NTPs, with a preference for ATP and GTP.|agonist:Mg2+|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/14 2020/10/28 - rogid:F98KM8XJ6ElyhUel43fFsarYA3g2697049 - false - maltose binding protein tag:n-n|sufficient binding region:1-586 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:15422" uniprotkb:P0DTD1-PRO_0000449630 intact:EBI-1108845|chebi:"CHEBI:40938"|chebi:"CHEBI:10841"|chebi:"CHEBI:10789"|chebi:"CHEBI:2359"|chebi:"CHEBI:13236"|chebi:"CHEBI:22249" intact:EBI-25475888 psi-mi:atp(display_short)|psi-mi:"CHEBI:15422"(display_long)|intact:Adenosine 5'-triphosphate(synonym)|intact:Adenosine triphosphate(synonym)|intact:ADENOSINE-5'-TRIPHOSPHATE(synonym)|intact:Adephos(synonym)|intact:Adetol(synonym)|intact:Adynol(synonym)|intact:Atipi(synonym)|intact:ATP(synonym)|intact:Atriphos(synonym)|intact:Cardenosine(synonym)|intact:Fosfobion(synonym)|intact:Glucobasin(synonym)|intact:H4atp(synonym)|intact:Myotriphos(synonym)|intact:Triadenyl(synonym)|intact:Triphosphaden(synonym)|intact:"adenosine 5'-(tetrahydrogen triphosphate)"(iupac name) psi-mi:p0dtd1-pro_0000449630(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0880"(atpase assay) Shu et al. (2020) pubmed:32500504|imex:IM-28459 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0882"(atpase reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26434849|imex:IM-28459-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) go:"GO:0016887"(ATP hydrolysis activity) - chain-seq-start:5325|chain-seq-end:5925 figure legend:5A, 6D|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/14 2020/10/29 - rogid:F98KM8XJ6ElyhUel43fFsarYA3g2697049 - false - maltose binding protein tag:n-n|sufficient binding region:1-586 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:15422" chebi:"CHEBI:77596" intact:EBI-1108845|chebi:"CHEBI:40938"|chebi:"CHEBI:10841"|chebi:"CHEBI:10789"|chebi:"CHEBI:2359"|chebi:"CHEBI:13236"|chebi:"CHEBI:22249" intact:EBI-26434861 psi-mi:atp(display_short)|psi-mi:"CHEBI:15422"(display_long)|intact:Adenosine 5'-triphosphate(synonym)|intact:Adenosine triphosphate(synonym)|intact:ADENOSINE-5'-TRIPHOSPHATE(synonym)|intact:Adephos(synonym)|intact:Adetol(synonym)|intact:Adynol(synonym)|intact:Atipi(synonym)|intact:ATP(synonym)|intact:Atriphos(synonym)|intact:Cardenosine(synonym)|intact:Fosfobion(synonym)|intact:Glucobasin(synonym)|intact:H4atp(synonym)|intact:Myotriphos(synonym)|intact:Triadenyl(synonym)|intact:Triphosphaden(synonym)|intact:"adenosine 5'-(tetrahydrogen triphosphate)"(iupac name) psi-mi:ranitidine bismuth citrate(display_short)|psi-mi:"CHEBI:77596"(display_long) psi-mi:"MI:0880"(atpase assay) Shu et al. (2020) pubmed:32500504|imex:IM-28459 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0882"(atpase reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26434849|imex:IM-28459-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0328"(small molecule) - - go:"GO:0016887"(ATP hydrolysis activity) - - figure legend:5A, 6D|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/14 2020/10/29 - - - false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:15422" chebi:"CHEBI:157699" intact:EBI-1108845|chebi:"CHEBI:40938"|chebi:"CHEBI:10841"|chebi:"CHEBI:10789"|chebi:"CHEBI:2359"|chebi:"CHEBI:13236"|chebi:"CHEBI:22249" intact:EBI-26434874 psi-mi:atp(display_short)|psi-mi:"CHEBI:15422"(display_long)|intact:Adenosine 5'-triphosphate(synonym)|intact:Adenosine triphosphate(synonym)|intact:ADENOSINE-5'-TRIPHOSPHATE(synonym)|intact:Adephos(synonym)|intact:Adetol(synonym)|intact:Adynol(synonym)|intact:Atipi(synonym)|intact:ATP(synonym)|intact:Atriphos(synonym)|intact:Cardenosine(synonym)|intact:Fosfobion(synonym)|intact:Glucobasin(synonym)|intact:H4atp(synonym)|intact:Myotriphos(synonym)|intact:Triadenyl(synonym)|intact:Triphosphaden(synonym)|intact:"adenosine 5'-(tetrahydrogen triphosphate)"(iupac name) psi-mi:bpc(display_short)|psi-mi:"CHEBI:157699"(display_long) psi-mi:"MI:0880"(atpase assay) Shu et al. (2020) pubmed:32500504|imex:IM-28459 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0882"(atpase reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26434864|imex:IM-28459-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0328"(small molecule) - - go:"GO:0016887"(ATP hydrolysis activity) - - figure legend:5A, 6A|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/14 2020/10/29 - - - false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:15422" uniprotkb:P0DTD1-PRO_0000449630 intact:EBI-1108845|chebi:"CHEBI:40938"|chebi:"CHEBI:10841"|chebi:"CHEBI:10789"|chebi:"CHEBI:2359"|chebi:"CHEBI:13236"|chebi:"CHEBI:22249" intact:EBI-25475888 psi-mi:atp(display_short)|psi-mi:"CHEBI:15422"(display_long)|intact:Adenosine 5'-triphosphate(synonym)|intact:Adenosine triphosphate(synonym)|intact:ADENOSINE-5'-TRIPHOSPHATE(synonym)|intact:Adephos(synonym)|intact:Adetol(synonym)|intact:Adynol(synonym)|intact:Atipi(synonym)|intact:ATP(synonym)|intact:Atriphos(synonym)|intact:Cardenosine(synonym)|intact:Fosfobion(synonym)|intact:Glucobasin(synonym)|intact:H4atp(synonym)|intact:Myotriphos(synonym)|intact:Triadenyl(synonym)|intact:Triphosphaden(synonym)|intact:"adenosine 5'-(tetrahydrogen triphosphate)"(iupac name) psi-mi:p0dtd1-pro_0000449630(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0880"(atpase assay) Shu et al. (2020) pubmed:32500504|imex:IM-28459 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0882"(atpase reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26434864|imex:IM-28459-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) go:"GO:0016887"(ATP hydrolysis activity) - chain-seq-start:5325|chain-seq-end:5925 figure legend:5A, 6A|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/14 2020/10/29 - rogid:F98KM8XJ6ElyhUel43fFsarYA3g2697049 - false - maltose binding protein tag:n-n|sufficient binding region:1-586 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:15422" chebi:"CHEBI:157700" intact:EBI-1108845|chebi:"CHEBI:40938"|chebi:"CHEBI:10841"|chebi:"CHEBI:10789"|chebi:"CHEBI:2359"|chebi:"CHEBI:13236"|chebi:"CHEBI:22249" intact:EBI-26434886 psi-mi:atp(display_short)|psi-mi:"CHEBI:15422"(display_long)|intact:Adenosine 5'-triphosphate(synonym)|intact:Adenosine triphosphate(synonym)|intact:ADENOSINE-5'-TRIPHOSPHATE(synonym)|intact:Adephos(synonym)|intact:Adetol(synonym)|intact:Adynol(synonym)|intact:Atipi(synonym)|intact:ATP(synonym)|intact:Atriphos(synonym)|intact:Cardenosine(synonym)|intact:Fosfobion(synonym)|intact:Glucobasin(synonym)|intact:H4atp(synonym)|intact:Myotriphos(synonym)|intact:Triadenyl(synonym)|intact:Triphosphaden(synonym)|intact:"adenosine 5'-(tetrahydrogen triphosphate)"(iupac name) psi-mi:bc(display_short)|psi-mi:"CHEBI:157700"(display_long) psi-mi:"MI:0880"(atpase assay) Shu et al. (2020) pubmed:32500504|imex:IM-28459 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0882"(atpase reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26434876|imex:IM-28459-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0328"(small molecule) - - go:"GO:0016887"(ATP hydrolysis activity) - - figure legend:5A|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/14 2020/10/29 - - - false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:15422" uniprotkb:P0DTD1-PRO_0000449630 intact:EBI-1108845|chebi:"CHEBI:40938"|chebi:"CHEBI:10841"|chebi:"CHEBI:10789"|chebi:"CHEBI:2359"|chebi:"CHEBI:13236"|chebi:"CHEBI:22249" intact:EBI-25475888 psi-mi:atp(display_short)|psi-mi:"CHEBI:15422"(display_long)|intact:Adenosine 5'-triphosphate(synonym)|intact:Adenosine triphosphate(synonym)|intact:ADENOSINE-5'-TRIPHOSPHATE(synonym)|intact:Adephos(synonym)|intact:Adetol(synonym)|intact:Adynol(synonym)|intact:Atipi(synonym)|intact:ATP(synonym)|intact:Atriphos(synonym)|intact:Cardenosine(synonym)|intact:Fosfobion(synonym)|intact:Glucobasin(synonym)|intact:H4atp(synonym)|intact:Myotriphos(synonym)|intact:Triadenyl(synonym)|intact:Triphosphaden(synonym)|intact:"adenosine 5'-(tetrahydrogen triphosphate)"(iupac name) psi-mi:p0dtd1-pro_0000449630(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0880"(atpase assay) Shu et al. (2020) pubmed:32500504|imex:IM-28459 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0882"(atpase reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26434876|imex:IM-28459-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) go:"GO:0016887"(ATP hydrolysis activity) - chain-seq-start:5325|chain-seq-end:5925 figure legend:5A|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/14 2020/10/29 - rogid:F98KM8XJ6ElyhUel43fFsarYA3g2697049 - false - maltose binding protein tag:n-n|sufficient binding region:1-586 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:15996" uniprotkb:P0DTD1-PRO_0000449630 intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451" intact:EBI-25475888 psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name) psi-mi:p0dtd1-pro_0000449630(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0419"(gtpase assay) Shu et al. (2020) pubmed:32500504|imex:IM-28459 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0883"(gtpase reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26430449|imex:IM-28459-5 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) go:"GO:0003924"(GTPase activity) author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2" chain-seq-start:5325|chain-seq-end:5925 figure legend:1A|comment:Recombinant SARS-CoV-2 nsp13 could hydrolyze all four types of NTPs, with a preference for ATP and GTP.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/14 2020/10/29 - rogid:F98KM8XJ6ElyhUel43fFsarYA3g2697049 - false - maltose binding protein tag:n-n|sufficient binding region:1-586 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0DTD1-PRO_0000449630 intact:EBI-26434661 intact:EBI-25475888 - psi-mi:p0dtd1-pro_0000449630(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:rna_1_long(display_short)|psi-mi:EBI-26434661(display_long) psi-mi:"MI:0415"(enzymatic study) Shu et al. (2020) pubmed:32500504|imex:IM-28459 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:32630(synthetic construct)|taxid:32630(synthetic construct) psi-mi:"MI:0414"(enzymatic reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26434652|imex:IM-28459-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0320"(ribonucleic acid) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) - - chain-seq-start:5325|chain-seq-end:5925 - figure legend:"2B-D, (5B), 6"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/14 2020/10/29 rogid:F98KM8XJ6ElyhUel43fFsarYA3g2697049 - - false maltose binding protein tag:n-n|sufficient binding region:1-586 fluorescein label:1-1|sufficient binding region:1-42 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:P0DTD1-PRO_0000449630 intact:EBI-26434666 intact:EBI-25475888 - psi-mi:p0dtd1-pro_0000449630(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:rna_2_short(display_short)|psi-mi:EBI-26434666(display_long) psi-mi:"MI:0415"(enzymatic study) Shu et al. (2020) pubmed:32500504|imex:IM-28459 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:-1(in vitro)|taxid:-1(In vitro) psi-mi:"MI:0414"(enzymatic reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26434652|imex:IM-28459-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0320"(ribonucleic acid) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) - - chain-seq-start:5325|chain-seq-end:5925 - figure legend:"2B-D, (5B), 6"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/14 2020/10/29 rogid:F98KM8XJ6ElyhUel43fFsarYA3g2697049 - - false maltose binding protein tag:n-n|sufficient binding region:1-586 sufficient binding region:1-24 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:P0DTD1-PRO_0000449630 intact:EBI-26434661 intact:EBI-25475888 - psi-mi:p0dtd1-pro_0000449630(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:rna_1_long(display_short)|psi-mi:EBI-26434661(display_long) psi-mi:"MI:0415"(enzymatic study) Shu et al. (2020) pubmed:32500504|imex:IM-28459 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:32630(synthetic construct)|taxid:32630(synthetic construct) psi-mi:"MI:0414"(enzymatic reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26434694|imex:IM-28459-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0320"(ribonucleic acid) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) - - chain-seq-start:5325|chain-seq-end:5925 - figure legend:3|agonist:ATP and GTP|comment:Efficiency of RNA helix-unwinding by nsp13 was limited in the presence of CTP and UTP.|agonist:Mg2+ and to a lesser extent Mn2+.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/14 2020/10/29 rogid:F98KM8XJ6ElyhUel43fFsarYA3g2697049 - - false maltose binding protein tag:n-n|sufficient binding region:1-586 fluorescein label:1-1|sufficient binding region:1-42 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:P0DTD1-PRO_0000449630 intact:EBI-26434737 intact:EBI-25475888 - psi-mi:p0dtd1-pro_0000449630(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:rna_3_short(display_short)|psi-mi:EBI-26434737(display_long) psi-mi:"MI:0415"(enzymatic study) Shu et al. (2020) pubmed:32500504|imex:IM-28459 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:-1(in vitro)|taxid:-1(In vitro) psi-mi:"MI:0414"(enzymatic reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26434694|imex:IM-28459-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0320"(ribonucleic acid) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) - - chain-seq-start:5325|chain-seq-end:5925 - figure legend:3|agonist:ATP and GTP|comment:Efficiency of RNA helix-unwinding by nsp13 was limited in the presence of CTP and UTP.|agonist:Mg2+ and to a lesser extent Mn2+.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/14 2020/10/29 rogid:F98KM8XJ6ElyhUel43fFsarYA3g2697049 - - false maltose binding protein tag:n-n|sufficient binding region:1-586 sufficient binding region:1-28 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:P0DTD1-PRO_0000449630 intact:EBI-26434661 intact:EBI-25475888 - psi-mi:p0dtd1-pro_0000449630(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:rna_1_long(display_short)|psi-mi:EBI-26434661(display_long) psi-mi:"MI:0415"(enzymatic study) Shu et al. (2020) pubmed:32500504|imex:IM-28459 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:32630(synthetic construct)|taxid:32630(synthetic construct) psi-mi:"MI:0414"(enzymatic reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26434768|imex:IM-28459-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0320"(ribonucleic acid) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) - - chain-seq-start:5325|chain-seq-end:5925 - figure legend:4, no 1|comment:SARS-CoV-2 nsp13 efficiently unwound the RNA helix substrate with 5′-protrusion.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/14 2020/10/29 rogid:F98KM8XJ6ElyhUel43fFsarYA3g2697049 - - false maltose binding protein tag:n-n|sufficient binding region:1-586 fluorescein label:1-1|sufficient binding region:1-42 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:P0DTD1-PRO_0000449630 intact:EBI-26434791 intact:EBI-25475888 - psi-mi:p0dtd1-pro_0000449630(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:rna_4_short(display_short)|psi-mi:EBI-26434791(display_long) psi-mi:"MI:0415"(enzymatic study) Shu et al. (2020) pubmed:32500504|imex:IM-28459 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:-1(in vitro)|taxid:-1(In vitro) psi-mi:"MI:0414"(enzymatic reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26434768|imex:IM-28459-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0320"(ribonucleic acid) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) - - chain-seq-start:5325|chain-seq-end:5925 - figure legend:4, no 1|comment:SARS-CoV-2 nsp13 efficiently unwound the RNA helix substrate with 5′-protrusion.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/14 2020/10/29 rogid:F98KM8XJ6ElyhUel43fFsarYA3g2697049 - - false maltose binding protein tag:n-n|sufficient binding region:1-586 sufficient binding region:1-24 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:P0DTD1-PRO_0000449630 intact:EBI-26434661 intact:EBI-25475888 - psi-mi:p0dtd1-pro_0000449630(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:rna_1_long(display_short)|psi-mi:EBI-26434661(display_long) psi-mi:"MI:0415"(enzymatic study) Shu et al. (2020) pubmed:32500504|imex:IM-28459 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:32630(synthetic construct)|taxid:32630(synthetic construct) psi-mi:"MI:0414"(enzymatic reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26434798|imex:IM-28459-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0320"(ribonucleic acid) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) - - chain-seq-start:5325|chain-seq-end:5925 - figure legend:4, no 2|comment:SARS-CoV-2 nsp13 unwound the RNA helix substrate with 3′-protrusion less efficiently. The RNA helix substrate with blunt ends was not unwound at all.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/14 2020/10/29 rogid:F98KM8XJ6ElyhUel43fFsarYA3g2697049 - - false maltose binding protein tag:n-n|sufficient binding region:1-586 fluorescein label:1-1|sufficient binding region:1-42 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:P0DTD1-PRO_0000449630 intact:EBI-26434815 intact:EBI-25475888 - psi-mi:p0dtd1-pro_0000449630(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:rna_5_short(display_short)|psi-mi:EBI-26434815(display_long) psi-mi:"MI:0415"(enzymatic study) Shu et al. (2020) pubmed:32500504|imex:IM-28459 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:-1(in vitro)|taxid:-1(In vitro) psi-mi:"MI:0414"(enzymatic reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26434798|imex:IM-28459-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0320"(ribonucleic acid) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) - - chain-seq-start:5325|chain-seq-end:5925 - figure legend:4, no 2|comment:SARS-CoV-2 nsp13 unwound the RNA helix substrate with 3′-protrusion less efficiently. The RNA helix substrate with blunt ends was not unwound at all.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/14 2020/10/29 rogid:F98KM8XJ6ElyhUel43fFsarYA3g2697049 - - false maltose binding protein tag:n-n|sufficient binding region:1-586 sufficient binding region:1-24 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) chebi:"CHEBI:157699" uniprotkb:P0DTD1-PRO_0000449630 intact:EBI-26434874 intact:EBI-25475888 psi-mi:bpc(display_short)|psi-mi:"CHEBI:157699"(display_long) psi-mi:p0dtd1-pro_0000449630(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0415"(enzymatic study) Shu et al. (2020) pubmed:32500504|imex:IM-28459 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0414"(enzymatic reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26434905|imex:IM-28459-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) - - chain-seq-start:5325|chain-seq-end:5925 figure legend:5B, 6 A-C.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/14 2020/10/29 - rogid:F98KM8XJ6ElyhUel43fFsarYA3g2697049 - false - maltose binding protein tag:n-n|sufficient binding region:1-586 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) chebi:"CHEBI:157699" intact:EBI-26434661 intact:EBI-26434874 - psi-mi:bpc(display_short)|psi-mi:"CHEBI:157699"(display_long) psi-mi:rna_1_long(display_short)|psi-mi:EBI-26434661(display_long) psi-mi:"MI:0415"(enzymatic study) Shu et al. (2020) pubmed:32500504|imex:IM-28459 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:32630(synthetic construct)|taxid:32630(synthetic construct) psi-mi:"MI:0414"(enzymatic reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26434905|imex:IM-28459-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0320"(ribonucleic acid) - - - - - figure legend:5B, 6 A-C.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/14 2020/10/29 - - - false - fluorescein label:1-1|sufficient binding region:1-42 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) chebi:"CHEBI:157699" intact:EBI-26434666 intact:EBI-26434874 - psi-mi:bpc(display_short)|psi-mi:"CHEBI:157699"(display_long) psi-mi:rna_2_short(display_short)|psi-mi:EBI-26434666(display_long) psi-mi:"MI:0415"(enzymatic study) Shu et al. (2020) pubmed:32500504|imex:IM-28459 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:-1(in vitro)|taxid:-1(In vitro) psi-mi:"MI:0414"(enzymatic reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26434905|imex:IM-28459-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0320"(ribonucleic acid) - - - - - figure legend:5B, 6 A-C.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/14 2020/10/29 - - - false - sufficient binding region:1-24 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) chebi:"CHEBI:77596" uniprotkb:P0DTD1-PRO_0000449630 intact:EBI-26434861 intact:EBI-25475888 psi-mi:ranitidine bismuth citrate(display_short)|psi-mi:"CHEBI:77596"(display_long) psi-mi:p0dtd1-pro_0000449630(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0415"(enzymatic study) Shu et al. (2020) pubmed:32500504|imex:IM-28459 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0414"(enzymatic reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26434923|imex:IM-28459-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) - - chain-seq-start:5325|chain-seq-end:5925 figure legend:5B, 6 D-F.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/14 2020/10/29 - rogid:F98KM8XJ6ElyhUel43fFsarYA3g2697049 - false - maltose binding protein tag:n-n|sufficient binding region:1-586 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:P0DTD1-PRO_0000449630 intact:EBI-26434661 intact:EBI-25475888 - psi-mi:p0dtd1-pro_0000449630(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:rna_1_long(display_short)|psi-mi:EBI-26434661(display_long) psi-mi:"MI:0415"(enzymatic study) Shu et al. (2020) pubmed:32500504|imex:IM-28459 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:32630(synthetic construct)|taxid:32630(synthetic construct) psi-mi:"MI:0414"(enzymatic reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26434923|imex:IM-28459-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0320"(ribonucleic acid) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) - - chain-seq-start:5325|chain-seq-end:5925 - figure legend:5B, 6 D-F.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/14 2020/10/29 rogid:F98KM8XJ6ElyhUel43fFsarYA3g2697049 - - false maltose binding protein tag:n-n|sufficient binding region:1-586 fluorescein label:1-1|sufficient binding region:1-42 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:P0DTD1-PRO_0000449630 intact:EBI-26434666 intact:EBI-25475888 - psi-mi:p0dtd1-pro_0000449630(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:rna_2_short(display_short)|psi-mi:EBI-26434666(display_long) psi-mi:"MI:0415"(enzymatic study) Shu et al. (2020) pubmed:32500504|imex:IM-28459 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:-1(in vitro)|taxid:-1(In vitro) psi-mi:"MI:0414"(enzymatic reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26434923|imex:IM-28459-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0320"(ribonucleic acid) intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) - - chain-seq-start:5325|chain-seq-end:5925 - figure legend:5B, 6 D-F.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/14 2020/10/29 rogid:F98KM8XJ6ElyhUel43fFsarYA3g2697049 - - false maltose binding protein tag:n-n|sufficient binding region:1-586 sufficient binding region:1-24 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) chebi:"CHEBI:157700" uniprotkb:P0DTD1-PRO_0000449630 intact:EBI-26434886 intact:EBI-25475888 psi-mi:bc(display_short)|psi-mi:"CHEBI:157700"(display_long) psi-mi:p0dtd1-pro_0000449630(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0415"(enzymatic study) Shu et al. (2020) pubmed:32500504|imex:IM-28459 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0414"(enzymatic reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26434941|imex:IM-28459-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent) - - chain-seq-start:5325|chain-seq-end:5925 figure legend:5B|comment:BC treatment also effectively inhibited the RNA helicase activity of nsp13, its inhibitory efficiency was in much less than BPC or RBC.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/14 2020/10/29 - rogid:F98KM8XJ6ElyhUel43fFsarYA3g2697049 - false - maltose binding protein tag:n-n|sufficient binding region:1-586 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) chebi:"CHEBI:157700" intact:EBI-26434661 intact:EBI-26434886 - psi-mi:bc(display_short)|psi-mi:"CHEBI:157700"(display_long) psi-mi:rna_1_long(display_short)|psi-mi:EBI-26434661(display_long) psi-mi:"MI:0415"(enzymatic study) Shu et al. (2020) pubmed:32500504|imex:IM-28459 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:32630(synthetic construct)|taxid:32630(synthetic construct) psi-mi:"MI:0414"(enzymatic reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26434941|imex:IM-28459-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0320"(ribonucleic acid) - - - - - figure legend:5B|comment:BC treatment also effectively inhibited the RNA helicase activity of nsp13, its inhibitory efficiency was in much less than BPC or RBC.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/14 2020/10/29 - - - false - fluorescein label:1-1|sufficient binding region:1-42 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) chebi:"CHEBI:157700" intact:EBI-26434666 intact:EBI-26434886 - psi-mi:bc(display_short)|psi-mi:"CHEBI:157700"(display_long) psi-mi:rna_2_short(display_short)|psi-mi:EBI-26434666(display_long) psi-mi:"MI:0415"(enzymatic study) Shu et al. (2020) pubmed:32500504|imex:IM-28459 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:-1(in vitro)|taxid:-1(In vitro) psi-mi:"MI:0414"(enzymatic reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26434941|imex:IM-28459-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0320"(ribonucleic acid) - - - - - figure legend:5B|comment:BC treatment also effectively inhibited the RNA helicase activity of nsp13, its inhibitory efficiency was in much less than BPC or RBC.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/14 2020/10/29 - - - false - sufficient binding region:1-24 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence)