#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O14649	uniprotkb:O14649	intact:EBI-8559445|intact:MINT-1645466|uniprotkb:Q53SU2|ensembl:ENSP00000306275	intact:EBI-8559445|intact:MINT-1645466|uniprotkb:Q53SU2|ensembl:ENSP00000306275	psi-mi:kcnk3_human(display_long)|uniprotkb:KCNK3(gene name)|psi-mi:KCNK3(display_short)|uniprotkb:TASK(gene name synonym)|uniprotkb:TASK1(gene name synonym)|uniprotkb:Acid-sensitive potassium channel protein TASK-1(gene name synonym)|uniprotkb:"TWIK-related acid-sensitive K(+) channel 1"(gene name synonym)|uniprotkb:Two pore potassium channel KT3.1(gene name synonym)	psi-mi:kcnk3_human(display_long)|uniprotkb:KCNK3(gene name)|psi-mi:KCNK3(display_short)|uniprotkb:TASK(gene name synonym)|uniprotkb:TASK1(gene name synonym)|uniprotkb:Acid-sensitive potassium channel protein TASK-1(gene name synonym)|uniprotkb:"TWIK-related acid-sensitive K(+) channel 1"(gene name synonym)|uniprotkb:Two pore potassium channel KT3.1(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Rödström et al. (2020)	pubmed:32499642|imex:IM-28310	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-25747561|wwpdb:6RV2|wwpdb:6RV3|wwpdb:6RV4|imex:IM-28310-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002237.1|ensembl:ENSG00000171303(gene)|ensembl:ENST00000302909(transcript)|go:"GO:0005216"(ion channel activity)|go:"GO:0005252"(open rectifier potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0022841"(potassium ion leak channel activity)|go:"GO:0030322"(stabilization of membrane potential)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042493"|go:"GO:0044548"(S100 protein binding)|go:"GO:0045202"(synapse)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0090102"(cochlea development)|interpro:IPR003092(Potassium channel, two pore-domain, TASK)|interpro:IPR003280(Potassium channel, two pore-domain)|interpro:IPR005406(Potassium channel, two pore-domain, TASK-1)|interpro:IPR013099(Ion transport 2)|rcsb pdb:6RV2|rcsb pdb:6RV3|rcsb pdb:6RV4|reactome:R-HSA-1299316|reactome:R-HSA-5576886	refseq:NP_002237.1|ensembl:ENSG00000171303(gene)|ensembl:ENST00000302909(transcript)|go:"GO:0005216"(ion channel activity)|go:"GO:0005252"(open rectifier potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0022841"(potassium ion leak channel activity)|go:"GO:0030322"(stabilization of membrane potential)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042493"|go:"GO:0044548"(S100 protein binding)|go:"GO:0045202"(synapse)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0090102"(cochlea development)|interpro:IPR003092(Potassium channel, two pore-domain, TASK)|interpro:IPR003280(Potassium channel, two pore-domain)|interpro:IPR005406(Potassium channel, two pore-domain, TASK-1)|interpro:IPR013099(Ion transport 2)|rcsb pdb:6RV2|rcsb pdb:6RV3|rcsb pdb:6RV4|reactome:R-HSA-1299316|reactome:R-HSA-5576886	-	comment:mint|function:pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward	comment:mint|function:pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward	figure legend:Fig 1, Ext Data Tab 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells)	-	2020/07/04	2020/07/04	rogid:DCgyygIkuz0HccOjC7nXdXS29Gk9606	rogid:DCgyygIkuz0HccOjC7nXdXS29Gk9606	rigid:Nk9m9x8Erwd9xCDJUGn2GThvb6g	false	binding-associated region:1-259	binding-associated region:1-259	2	0	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)