#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q78DX7 uniprotkb:Q61220 intact:EBI-7800362|ensembl:ENSMUSP00000020045|intact:MINT-192643|uniprotkb:Q60705 intact:EBI-25745541|ensembl:ENSMUSP00000074751|ensembl:ENSMUSP00000131665|uniprotkb:Q80UM5 psi-mi:ros1_mouse(display_long)|uniprotkb:Ros1(gene name)|psi-mi:Ros1(display_short)|uniprotkb:Ros-1(gene name synonym)|uniprotkb:Proto-oncogene c-Ros(gene name synonym)|uniprotkb:Proto-oncogene c-Ros-1(gene name synonym)|uniprotkb:Receptor tyrosine kinase c-ros oncogene 1(gene name synonym)|uniprotkb:Ros(gene name synonym)|uniprotkb:c-Ros receptor tyrosine kinase(gene name synonym) psi-mi:nell2_mouse(display_long)|uniprotkb:Nell2(gene name)|psi-mi:Nell2(display_short)|uniprotkb:MEL91 protein(gene name synonym)|uniprotkb:Mel91(gene name synonym)|uniprotkb:NEL-like protein 2(gene name synonym) psi-mi:"MI:0096"(pull down) Kiyozumi et al. (2020) imex:IM-28166|pubmed:32499443 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-25745538|imex:IM-28166-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0043235"(receptor complex)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|ensembl:ENSMUSG00000019893(gene)|ensembl:ENSMUST00000020045(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0002066"(columnar/cuboidal epithelial cell development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010467"(gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010966"(regulation of phosphate transport)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0033674"(positive regulation of kinase activity)|refseq:NP_035412.2 ensembl:ENSMUSG00000022454(gene)|ensembl:ENSMUST00000075275(transcript)|ensembl:ENSMUST00000166170(transcript)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0008201"(heparin binding)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0046543"(development of secondary female sexual characteristics)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0070050"(neuron cellular homeostasis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018097|interpro:IPR024731|refseq:NP_001276582.1|refseq:XP_006521226.1|refseq:XP_011243995.1 - comment:mint|function:This is probably a cell growth or differentiation factor receptor with a tyrosine-protein kinase activity - figure legend:FIg1a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/07/01 2020/07/02 rogid:LzNQ4xzyD5LlrcgEF8QU/ZCuNTU10090 rogid:8ytZKRhtCDkGOtnHhDTkpClNaoQ10090 rigid:3PC28DjWmift9x6vHIbcUTFjXKI false flag tag:c-c his tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0396"(predetermined participant)