#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9H4I9	uniprotkb:Q8NE86	intact:EBI-11908005|ensembl:ENSP00000327467|ensembl:ENSP00000459368|ensembl:ENSP00000475471|ensembl:ENSP00000485029|uniprotkb:B2R5D1|uniprotkb:Q8TAB9	intact:EBI-6552124|ensembl:ENSP00000362144|uniprotkb:B2RDF3|uniprotkb:B3KXV7|uniprotkb:Q96FL3	psi-mi:emre_human(display_long)|uniprotkb:SMDT1(gene name)|psi-mi:SMDT1(display_short)|uniprotkb:C22orf32(gene name synonym)|uniprotkb:EMRE(gene name synonym)|uniprotkb:Single-pass membrane protein with aspartate-rich tail 1, mitochondrial(gene name synonym)	psi-mi:mcu_human(display_long)|uniprotkb:MCU(gene name)|psi-mi:MCU(display_short)|uniprotkb:C10orf42(gene name synonym)|uniprotkb:CCDC109A(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 109A(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Fan et al. (2020)	pubmed:32494073|imex:IM-28151	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25745614|wwpdb:6wdn|emdb:EMD-21642|imex:IM-28151-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000183172(gene)|ensembl:ENSG00000272835(gene)|ensembl:ENSG00000272901(gene)|ensembl:ENSG00000274112(gene)|ensembl:ENST00000331479(transcript)|ensembl:ENST00000571525(transcript)|ensembl:ENST00000607293(transcript)|ensembl:ENST00000615504(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:1990246"(uniplex complex)|interpro:IPR018782|rcsb pdb:6K7X|rcsb pdb:6K7Y|rcsb pdb:6O58|rcsb pdb:6O5B|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|reactome:R-HSA-8949215|reactome:R-HSA-8949664|refseq:NP_201575.3|refseq:XP_011528811.1	go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1990246"(uniplex complex)|interpro:IPR006769(Protein of unknown function DUF607)|interpro:IPR039055|rcsb pdb:4XSJ|rcsb pdb:4XTB|rcsb pdb:5BZ6|rcsb pdb:5KUE|rcsb pdb:5KUG|rcsb pdb:5KUI|rcsb pdb:5KUJ|rcsb pdb:6JG0|rcsb pdb:6K7X|rcsb pdb:6K7Y|rcsb pdb:6KVX|rcsb pdb:6O58|rcsb pdb:6O5B|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|reactome:R-HSA-8949215|reactome:R-HSA-8949664|go:"GO:0019722"(calcium-mediated signaling)|ensembl:ENSG00000156026(gene)|ensembl:ENST00000373053(transcript)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0015292"(uniporter activity)|refseq:NP_001257608.1|refseq:NP_001257609.1|refseq:NP_612366.1|dip:DIP-60468N	-	-	-	comment:Low Calcium|figure legend:Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293s)|taxid:9606(Human 293S cell line)	-	2020/07/02	2020/07/02	rogid:GzSAPUzq7COaeqDVh6pJkbd2eCE9606	rogid:t2fSATmrk7IEC0nMpquAoPB3CHs9606	rigid:zs7tR8YoOfwmGjnWPoQDtWB/apU	false	sufficient binding region:48-98|strep tag:c-c	sufficient binding region:169-346	4	4	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:Q9H4I9	uniprotkb:Q9BPX6	intact:EBI-11908005|ensembl:ENSP00000327467|ensembl:ENSP00000459368|ensembl:ENSP00000475471|ensembl:ENSP00000485029|uniprotkb:B2R5D1|uniprotkb:Q8TAB9	intact:EBI-2371996|uniprotkb:O75785|uniprotkb:Q9H9N6|uniprotkb:Q9UFX0|uniprotkb:A8MV96|uniprotkb:B3KN20|uniprotkb:B4DJH9|uniprotkb:B4DPI1|uniprotkb:B5MBY3|uniprotkb:D3YTJ3|ensembl:ENSP00000354415	psi-mi:emre_human(display_long)|uniprotkb:SMDT1(gene name)|psi-mi:SMDT1(display_short)|uniprotkb:C22orf32(gene name synonym)|uniprotkb:EMRE(gene name synonym)|uniprotkb:Single-pass membrane protein with aspartate-rich tail 1, mitochondrial(gene name synonym)	psi-mi:micu1_human(display_long)|uniprotkb:MICU1(gene name)|psi-mi:MICU1(display_short)|uniprotkb:Calcium-binding atopy-related autoantigen 1(gene name synonym)|uniprotkb:CBARA1(gene name synonym)|uniprotkb:CALC(gene name synonym)|uniprotkb:Atopy-related autoantigen CALC(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Fan et al. (2020)	pubmed:32494073|imex:IM-28151	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25745614|wwpdb:6wdn|emdb:EMD-21642|imex:IM-28151-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000183172(gene)|ensembl:ENSG00000272835(gene)|ensembl:ENSG00000272901(gene)|ensembl:ENSG00000274112(gene)|ensembl:ENST00000331479(transcript)|ensembl:ENST00000571525(transcript)|ensembl:ENST00000607293(transcript)|ensembl:ENST00000615504(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:1990246"(uniplex complex)|interpro:IPR018782|rcsb pdb:6K7X|rcsb pdb:6K7Y|rcsb pdb:6O58|rcsb pdb:6O5B|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|reactome:R-HSA-8949215|reactome:R-HSA-8949664|refseq:NP_201575.3|refseq:XP_011528811.1	refseq:NP_001182447.1|refseq:NP_001182448.1|refseq:NP_006068.2|dip:DIP-53438N|ensembl:ENSG00000107745(gene)|ensembl:ENST00000361114(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006952"(defense response)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0070509"(calcium ion import)|go:"GO:1900069"(regulation of cellular hyperosmotic salinity response)|go:"GO:1990246"(uniplex complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR039800|rcsb pdb:4NSC|rcsb pdb:4NSD|rcsb pdb:6K7Y|rcsb pdb:6LB7|rcsb pdb:6LB8|rcsb pdb:6LE5|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJX|rcsb pdb:6XQN|rcsb pdb:6XQO|reactome:R-HSA-8949215|reactome:R-HSA-8949664|rcsb pdb:6XJV	-	-	-	comment:Low Calcium|figure legend:Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293s)|taxid:9606(Human 293S cell line)	-	2020/07/02	2020/07/02	rogid:GzSAPUzq7COaeqDVh6pJkbd2eCE9606	rogid:ieoktRyh6dR8RvLctKOhbT84qPU9606	rigid:zs7tR8YoOfwmGjnWPoQDtWB/apU	false	sufficient binding region:48-98|strep tag:c-c	sufficient binding region:104-466	4	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:Q9H4I9	uniprotkb:Q8IYU8	intact:EBI-11908005|ensembl:ENSP00000327467|ensembl:ENSP00000459368|ensembl:ENSP00000475471|ensembl:ENSP00000485029|uniprotkb:B2R5D1|uniprotkb:Q8TAB9	intact:EBI-3197790|ensembl:ENSP00000371811|uniprotkb:Q8N0T6|uniprotkb:Q8NAX8	psi-mi:emre_human(display_long)|uniprotkb:SMDT1(gene name)|psi-mi:SMDT1(display_short)|uniprotkb:C22orf32(gene name synonym)|uniprotkb:EMRE(gene name synonym)|uniprotkb:Single-pass membrane protein with aspartate-rich tail 1, mitochondrial(gene name synonym)	psi-mi:micu2_human(display_long)|uniprotkb:MICU2(gene name)|psi-mi:MICU2(display_short)|uniprotkb:EF-hand domain-containing family member A1(gene name synonym)|uniprotkb:EFHA1(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Fan et al. (2020)	pubmed:32494073|imex:IM-28151	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25745614|wwpdb:6wdn|emdb:EMD-21642|imex:IM-28151-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000183172(gene)|ensembl:ENSG00000272835(gene)|ensembl:ENSG00000272901(gene)|ensembl:ENSG00000274112(gene)|ensembl:ENST00000331479(transcript)|ensembl:ENST00000571525(transcript)|ensembl:ENST00000607293(transcript)|ensembl:ENST00000615504(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:1990246"(uniplex complex)|interpro:IPR018782|rcsb pdb:6K7X|rcsb pdb:6K7Y|rcsb pdb:6O58|rcsb pdb:6O5B|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|reactome:R-HSA-8949215|reactome:R-HSA-8949664|refseq:NP_201575.3|refseq:XP_011528811.1	ensembl:ENSG00000165487(gene)|ensembl:ENST00000382374(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0051562"(negative regulation of mitochondrial calcium ion concentration)|go:"GO:1990246"(uniplex complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR039800|rcsb pdb:6AGH|rcsb pdb:6IIH|rcsb pdb:6K7Y|rcsb pdb:6LB7|rcsb pdb:6LB8|rcsb pdb:6LE5|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|rcsb pdb:6XQN|rcsb pdb:6XQO|reactome:R-HSA-8949215|reactome:R-HSA-8949664|refseq:NP_689939.1	-	-	-	comment:Low Calcium|figure legend:Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293s)|taxid:9606(Human 293S cell line)	-	2020/07/02	2020/07/02	rogid:GzSAPUzq7COaeqDVh6pJkbd2eCE9606	rogid:qj7nAE+DvoW/RWlr4VWGSbhS6Mc9606	rigid:zs7tR8YoOfwmGjnWPoQDtWB/apU	false	sufficient binding region:48-98|strep tag:c-c	sufficient binding region:84-418	4	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:Q9H4I9	uniprotkb:Q8NE86	intact:EBI-11908005|ensembl:ENSP00000327467|ensembl:ENSP00000459368|ensembl:ENSP00000475471|ensembl:ENSP00000485029|uniprotkb:B2R5D1|uniprotkb:Q8TAB9	intact:EBI-6552124|ensembl:ENSP00000362144|uniprotkb:B2RDF3|uniprotkb:B3KXV7|uniprotkb:Q96FL3	psi-mi:emre_human(display_long)|uniprotkb:SMDT1(gene name)|psi-mi:SMDT1(display_short)|uniprotkb:C22orf32(gene name synonym)|uniprotkb:EMRE(gene name synonym)|uniprotkb:Single-pass membrane protein with aspartate-rich tail 1, mitochondrial(gene name synonym)	psi-mi:mcu_human(display_long)|uniprotkb:MCU(gene name)|psi-mi:MCU(display_short)|uniprotkb:C10orf42(gene name synonym)|uniprotkb:CCDC109A(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 109A(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Fan et al. (2020)	pubmed:32494073|imex:IM-28151	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25747881|emdb:EMD-21643|imex:IM-28151-3|wwpdb:6wdo	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000183172(gene)|ensembl:ENSG00000272835(gene)|ensembl:ENSG00000272901(gene)|ensembl:ENSG00000274112(gene)|ensembl:ENST00000331479(transcript)|ensembl:ENST00000571525(transcript)|ensembl:ENST00000607293(transcript)|ensembl:ENST00000615504(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:1990246"(uniplex complex)|interpro:IPR018782|rcsb pdb:6K7X|rcsb pdb:6K7Y|rcsb pdb:6O58|rcsb pdb:6O5B|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|reactome:R-HSA-8949215|reactome:R-HSA-8949664|refseq:NP_201575.3|refseq:XP_011528811.1	go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1990246"(uniplex complex)|interpro:IPR006769(Protein of unknown function DUF607)|interpro:IPR039055|rcsb pdb:4XSJ|rcsb pdb:4XTB|rcsb pdb:5BZ6|rcsb pdb:5KUE|rcsb pdb:5KUG|rcsb pdb:5KUI|rcsb pdb:5KUJ|rcsb pdb:6JG0|rcsb pdb:6K7X|rcsb pdb:6K7Y|rcsb pdb:6KVX|rcsb pdb:6O58|rcsb pdb:6O5B|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|reactome:R-HSA-8949215|reactome:R-HSA-8949664|go:"GO:0019722"(calcium-mediated signaling)|ensembl:ENSG00000156026(gene)|ensembl:ENST00000373053(transcript)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0015292"(uniporter activity)|refseq:NP_001257608.1|refseq:NP_001257609.1|refseq:NP_612366.1|dip:DIP-60468N	-	-	-	comment:"High Calcium (2mM). The structure forms a back-to-back dimer."|figure legend:Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293s)|taxid:9606(Human 293S cell line)	-	2020/07/02	2020/07/06	rogid:GzSAPUzq7COaeqDVh6pJkbd2eCE9606	rogid:t2fSATmrk7IEC0nMpquAoPB3CHs9606	rigid:zs7tR8YoOfwmGjnWPoQDtWB/apU	false	sufficient binding region:48-100|strep tag:c-c	sufficient binding region:74-346	8	8	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:Q9H4I9	uniprotkb:Q9BPX6	intact:EBI-11908005|ensembl:ENSP00000327467|ensembl:ENSP00000459368|ensembl:ENSP00000475471|ensembl:ENSP00000485029|uniprotkb:B2R5D1|uniprotkb:Q8TAB9	intact:EBI-2371996|uniprotkb:O75785|uniprotkb:Q9H9N6|uniprotkb:Q9UFX0|uniprotkb:A8MV96|uniprotkb:B3KN20|uniprotkb:B4DJH9|uniprotkb:B4DPI1|uniprotkb:B5MBY3|uniprotkb:D3YTJ3|ensembl:ENSP00000354415	psi-mi:emre_human(display_long)|uniprotkb:SMDT1(gene name)|psi-mi:SMDT1(display_short)|uniprotkb:C22orf32(gene name synonym)|uniprotkb:EMRE(gene name synonym)|uniprotkb:Single-pass membrane protein with aspartate-rich tail 1, mitochondrial(gene name synonym)	psi-mi:micu1_human(display_long)|uniprotkb:MICU1(gene name)|psi-mi:MICU1(display_short)|uniprotkb:Calcium-binding atopy-related autoantigen 1(gene name synonym)|uniprotkb:CBARA1(gene name synonym)|uniprotkb:CALC(gene name synonym)|uniprotkb:Atopy-related autoantigen CALC(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Fan et al. (2020)	pubmed:32494073|imex:IM-28151	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25747881|emdb:EMD-21643|imex:IM-28151-3|wwpdb:6wdo	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000183172(gene)|ensembl:ENSG00000272835(gene)|ensembl:ENSG00000272901(gene)|ensembl:ENSG00000274112(gene)|ensembl:ENST00000331479(transcript)|ensembl:ENST00000571525(transcript)|ensembl:ENST00000607293(transcript)|ensembl:ENST00000615504(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:1990246"(uniplex complex)|interpro:IPR018782|rcsb pdb:6K7X|rcsb pdb:6K7Y|rcsb pdb:6O58|rcsb pdb:6O5B|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|reactome:R-HSA-8949215|reactome:R-HSA-8949664|refseq:NP_201575.3|refseq:XP_011528811.1	refseq:NP_001182447.1|refseq:NP_001182448.1|refseq:NP_006068.2|dip:DIP-53438N|ensembl:ENSG00000107745(gene)|ensembl:ENST00000361114(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006952"(defense response)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0070509"(calcium ion import)|go:"GO:1900069"(regulation of cellular hyperosmotic salinity response)|go:"GO:1990246"(uniplex complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR039800|rcsb pdb:4NSC|rcsb pdb:4NSD|rcsb pdb:6K7Y|rcsb pdb:6LB7|rcsb pdb:6LB8|rcsb pdb:6LE5|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJX|rcsb pdb:6XQN|rcsb pdb:6XQO|reactome:R-HSA-8949215|reactome:R-HSA-8949664|rcsb pdb:6XJV	-	-	-	comment:"High Calcium (2mM). The structure forms a back-to-back dimer."|figure legend:Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293s)|taxid:9606(Human 293S cell line)	-	2020/07/02	2020/07/06	rogid:GzSAPUzq7COaeqDVh6pJkbd2eCE9606	rogid:ieoktRyh6dR8RvLctKOhbT84qPU9606	rigid:zs7tR8YoOfwmGjnWPoQDtWB/apU	false	sufficient binding region:48-100|strep tag:c-c	sufficient binding region:104-442	8	2	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:Q9H4I9	uniprotkb:Q8IYU8	intact:EBI-11908005|ensembl:ENSP00000327467|ensembl:ENSP00000459368|ensembl:ENSP00000475471|ensembl:ENSP00000485029|uniprotkb:B2R5D1|uniprotkb:Q8TAB9	intact:EBI-3197790|ensembl:ENSP00000371811|uniprotkb:Q8N0T6|uniprotkb:Q8NAX8	psi-mi:emre_human(display_long)|uniprotkb:SMDT1(gene name)|psi-mi:SMDT1(display_short)|uniprotkb:C22orf32(gene name synonym)|uniprotkb:EMRE(gene name synonym)|uniprotkb:Single-pass membrane protein with aspartate-rich tail 1, mitochondrial(gene name synonym)	psi-mi:micu2_human(display_long)|uniprotkb:MICU2(gene name)|psi-mi:MICU2(display_short)|uniprotkb:EF-hand domain-containing family member A1(gene name synonym)|uniprotkb:EFHA1(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Fan et al. (2020)	pubmed:32494073|imex:IM-28151	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25747881|emdb:EMD-21643|imex:IM-28151-3|wwpdb:6wdo	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000183172(gene)|ensembl:ENSG00000272835(gene)|ensembl:ENSG00000272901(gene)|ensembl:ENSG00000274112(gene)|ensembl:ENST00000331479(transcript)|ensembl:ENST00000571525(transcript)|ensembl:ENST00000607293(transcript)|ensembl:ENST00000615504(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:1990246"(uniplex complex)|interpro:IPR018782|rcsb pdb:6K7X|rcsb pdb:6K7Y|rcsb pdb:6O58|rcsb pdb:6O5B|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|reactome:R-HSA-8949215|reactome:R-HSA-8949664|refseq:NP_201575.3|refseq:XP_011528811.1	ensembl:ENSG00000165487(gene)|ensembl:ENST00000382374(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0051562"(negative regulation of mitochondrial calcium ion concentration)|go:"GO:1990246"(uniplex complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR039800|rcsb pdb:6AGH|rcsb pdb:6IIH|rcsb pdb:6K7Y|rcsb pdb:6LB7|rcsb pdb:6LB8|rcsb pdb:6LE5|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|rcsb pdb:6XQN|rcsb pdb:6XQO|reactome:R-HSA-8949215|reactome:R-HSA-8949664|refseq:NP_689939.1	-	-	-	comment:"High Calcium (2mM). The structure forms a back-to-back dimer."|figure legend:Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293s)|taxid:9606(Human 293S cell line)	-	2020/07/02	2020/07/06	rogid:GzSAPUzq7COaeqDVh6pJkbd2eCE9606	rogid:qj7nAE+DvoW/RWlr4VWGSbhS6Mc9606	rigid:zs7tR8YoOfwmGjnWPoQDtWB/apU	false	sufficient binding region:48-100|strep tag:c-c	sufficient binding region:85-394	8	2	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:Q9H4I9	uniprotkb:Q8NE86	intact:EBI-11908005|ensembl:ENSP00000327467|ensembl:ENSP00000459368|ensembl:ENSP00000475471|ensembl:ENSP00000485029|uniprotkb:B2R5D1|uniprotkb:Q8TAB9	intact:EBI-6552124|ensembl:ENSP00000362144|uniprotkb:B2RDF3|uniprotkb:B3KXV7|uniprotkb:Q96FL3	psi-mi:emre_human(display_long)|uniprotkb:SMDT1(gene name)|psi-mi:SMDT1(display_short)|uniprotkb:C22orf32(gene name synonym)|uniprotkb:EMRE(gene name synonym)|uniprotkb:Single-pass membrane protein with aspartate-rich tail 1, mitochondrial(gene name synonym)	psi-mi:mcu_human(display_long)|uniprotkb:MCU(gene name)|psi-mi:MCU(display_short)|uniprotkb:C10orf42(gene name synonym)|uniprotkb:CCDC109A(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 109A(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Fan et al. (2020)	pubmed:32494073|imex:IM-28151	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25747925|imex:IM-28151-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000183172(gene)|ensembl:ENSG00000272835(gene)|ensembl:ENSG00000272901(gene)|ensembl:ENSG00000274112(gene)|ensembl:ENST00000331479(transcript)|ensembl:ENST00000571525(transcript)|ensembl:ENST00000607293(transcript)|ensembl:ENST00000615504(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:1990246"(uniplex complex)|interpro:IPR018782|rcsb pdb:6K7X|rcsb pdb:6K7Y|rcsb pdb:6O58|rcsb pdb:6O5B|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|reactome:R-HSA-8949215|reactome:R-HSA-8949664|refseq:NP_201575.3|refseq:XP_011528811.1	go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1990246"(uniplex complex)|interpro:IPR006769(Protein of unknown function DUF607)|interpro:IPR039055|rcsb pdb:4XSJ|rcsb pdb:4XTB|rcsb pdb:5BZ6|rcsb pdb:5KUE|rcsb pdb:5KUG|rcsb pdb:5KUI|rcsb pdb:5KUJ|rcsb pdb:6JG0|rcsb pdb:6K7X|rcsb pdb:6K7Y|rcsb pdb:6KVX|rcsb pdb:6O58|rcsb pdb:6O5B|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|reactome:R-HSA-8949215|reactome:R-HSA-8949664|go:"GO:0019722"(calcium-mediated signaling)|ensembl:ENSG00000156026(gene)|ensembl:ENST00000373053(transcript)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0015292"(uniporter activity)|refseq:NP_001257608.1|refseq:NP_001257609.1|refseq:NP_612366.1|dip:DIP-60468N	-	-	-	comment:Low Calcium. The presence of a MCU Asp123Arg mutation changes the complex from a dimeric to a monomeric assembly|figure legend:Supp. Fig. 1A, 1B, 7C, 7D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2020/07/02	2020/09/28	rogid:GzSAPUzq7COaeqDVh6pJkbd2eCE9606	rogid:t2fSATmrk7IEC0nMpquAoPB3CHs9606	rigid:zs7tR8YoOfwmGjnWPoQDtWB/apU	false	sufficient binding region:48-98|strep tag:c-c	sufficient binding region:196-346	4	4	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:Q9H4I9	uniprotkb:Q9BPX6	intact:EBI-11908005|ensembl:ENSP00000327467|ensembl:ENSP00000459368|ensembl:ENSP00000475471|ensembl:ENSP00000485029|uniprotkb:B2R5D1|uniprotkb:Q8TAB9	intact:EBI-2371996|uniprotkb:O75785|uniprotkb:Q9H9N6|uniprotkb:Q9UFX0|uniprotkb:A8MV96|uniprotkb:B3KN20|uniprotkb:B4DJH9|uniprotkb:B4DPI1|uniprotkb:B5MBY3|uniprotkb:D3YTJ3|ensembl:ENSP00000354415	psi-mi:emre_human(display_long)|uniprotkb:SMDT1(gene name)|psi-mi:SMDT1(display_short)|uniprotkb:C22orf32(gene name synonym)|uniprotkb:EMRE(gene name synonym)|uniprotkb:Single-pass membrane protein with aspartate-rich tail 1, mitochondrial(gene name synonym)	psi-mi:micu1_human(display_long)|uniprotkb:MICU1(gene name)|psi-mi:MICU1(display_short)|uniprotkb:Calcium-binding atopy-related autoantigen 1(gene name synonym)|uniprotkb:CBARA1(gene name synonym)|uniprotkb:CALC(gene name synonym)|uniprotkb:Atopy-related autoantigen CALC(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Fan et al. (2020)	pubmed:32494073|imex:IM-28151	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25747925|imex:IM-28151-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000183172(gene)|ensembl:ENSG00000272835(gene)|ensembl:ENSG00000272901(gene)|ensembl:ENSG00000274112(gene)|ensembl:ENST00000331479(transcript)|ensembl:ENST00000571525(transcript)|ensembl:ENST00000607293(transcript)|ensembl:ENST00000615504(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:1990246"(uniplex complex)|interpro:IPR018782|rcsb pdb:6K7X|rcsb pdb:6K7Y|rcsb pdb:6O58|rcsb pdb:6O5B|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|reactome:R-HSA-8949215|reactome:R-HSA-8949664|refseq:NP_201575.3|refseq:XP_011528811.1	refseq:NP_001182447.1|refseq:NP_001182448.1|refseq:NP_006068.2|dip:DIP-53438N|ensembl:ENSG00000107745(gene)|ensembl:ENST00000361114(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006952"(defense response)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0070509"(calcium ion import)|go:"GO:1900069"(regulation of cellular hyperosmotic salinity response)|go:"GO:1990246"(uniplex complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR039800|rcsb pdb:4NSC|rcsb pdb:4NSD|rcsb pdb:6K7Y|rcsb pdb:6LB7|rcsb pdb:6LB8|rcsb pdb:6LE5|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJX|rcsb pdb:6XQN|rcsb pdb:6XQO|reactome:R-HSA-8949215|reactome:R-HSA-8949664|rcsb pdb:6XJV	-	-	-	comment:Low Calcium. The presence of a MCU Asp123Arg mutation changes the complex from a dimeric to a monomeric assembly|figure legend:Supp. Fig. 1A, 1B, 7C, 7D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2020/07/02	2020/09/28	rogid:GzSAPUzq7COaeqDVh6pJkbd2eCE9606	rogid:ieoktRyh6dR8RvLctKOhbT84qPU9606	rigid:zs7tR8YoOfwmGjnWPoQDtWB/apU	false	sufficient binding region:48-98|strep tag:c-c	sufficient binding region:104-466	4	1	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:Q9H4I9	uniprotkb:Q8IYU8	intact:EBI-11908005|ensembl:ENSP00000327467|ensembl:ENSP00000459368|ensembl:ENSP00000475471|ensembl:ENSP00000485029|uniprotkb:B2R5D1|uniprotkb:Q8TAB9	intact:EBI-3197790|ensembl:ENSP00000371811|uniprotkb:Q8N0T6|uniprotkb:Q8NAX8	psi-mi:emre_human(display_long)|uniprotkb:SMDT1(gene name)|psi-mi:SMDT1(display_short)|uniprotkb:C22orf32(gene name synonym)|uniprotkb:EMRE(gene name synonym)|uniprotkb:Single-pass membrane protein with aspartate-rich tail 1, mitochondrial(gene name synonym)	psi-mi:micu2_human(display_long)|uniprotkb:MICU2(gene name)|psi-mi:MICU2(display_short)|uniprotkb:EF-hand domain-containing family member A1(gene name synonym)|uniprotkb:EFHA1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Fan et al. (2020)	pubmed:32494073|imex:IM-28151	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25747925|imex:IM-28151-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000183172(gene)|ensembl:ENSG00000272835(gene)|ensembl:ENSG00000272901(gene)|ensembl:ENSG00000274112(gene)|ensembl:ENST00000331479(transcript)|ensembl:ENST00000571525(transcript)|ensembl:ENST00000607293(transcript)|ensembl:ENST00000615504(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:1990246"(uniplex complex)|interpro:IPR018782|rcsb pdb:6K7X|rcsb pdb:6K7Y|rcsb pdb:6O58|rcsb pdb:6O5B|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|reactome:R-HSA-8949215|reactome:R-HSA-8949664|refseq:NP_201575.3|refseq:XP_011528811.1	ensembl:ENSG00000165487(gene)|ensembl:ENST00000382374(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0051562"(negative regulation of mitochondrial calcium ion concentration)|go:"GO:1990246"(uniplex complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR039800|rcsb pdb:6AGH|rcsb pdb:6IIH|rcsb pdb:6K7Y|rcsb pdb:6LB7|rcsb pdb:6LB8|rcsb pdb:6LE5|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|rcsb pdb:6XQN|rcsb pdb:6XQO|reactome:R-HSA-8949215|reactome:R-HSA-8949664|refseq:NP_689939.1	-	-	-	comment:Low Calcium. The presence of a MCU Asp123Arg mutation changes the complex from a dimeric to a monomeric assembly|figure legend:Supp. Fig. 1A, 1B, 7C, 7D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2020/07/02	2020/09/28	rogid:GzSAPUzq7COaeqDVh6pJkbd2eCE9606	rogid:qj7nAE+DvoW/RWlr4VWGSbhS6Mc9606	rigid:zs7tR8YoOfwmGjnWPoQDtWB/apU	false	sufficient binding region:48-98|strep tag:c-c	sufficient binding region:84-418|mutation with no effect:121-121|mutation with no effect:107-107,120-121,154-154	4	1	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:Q9BPX6	uniprotkb:Q8IYU8	intact:EBI-2371996|uniprotkb:O75785|uniprotkb:Q9H9N6|uniprotkb:Q9UFX0|uniprotkb:A8MV96|uniprotkb:B3KN20|uniprotkb:B4DJH9|uniprotkb:B4DPI1|uniprotkb:B5MBY3|uniprotkb:D3YTJ3|ensembl:ENSP00000354415	intact:EBI-3197790|ensembl:ENSP00000371811|uniprotkb:Q8N0T6|uniprotkb:Q8NAX8	psi-mi:micu1_human(display_long)|uniprotkb:MICU1(gene name)|psi-mi:MICU1(display_short)|uniprotkb:Calcium-binding atopy-related autoantigen 1(gene name synonym)|uniprotkb:CBARA1(gene name synonym)|uniprotkb:CALC(gene name synonym)|uniprotkb:Atopy-related autoantigen CALC(gene name synonym)	psi-mi:micu2_human(display_long)|uniprotkb:MICU2(gene name)|psi-mi:MICU2(display_short)|uniprotkb:EF-hand domain-containing family member A1(gene name synonym)|uniprotkb:EFHA1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Fan et al. (2020)	pubmed:32494073|imex:IM-28151	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25747953|imex:IM-28151-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001182447.1|refseq:NP_001182448.1|refseq:NP_006068.2|dip:DIP-53438N|ensembl:ENSG00000107745(gene)|ensembl:ENST00000361114(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006952"(defense response)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0070509"(calcium ion import)|go:"GO:1900069"(regulation of cellular hyperosmotic salinity response)|go:"GO:1990246"(uniplex complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR039800|rcsb pdb:4NSC|rcsb pdb:4NSD|rcsb pdb:6K7Y|rcsb pdb:6LB7|rcsb pdb:6LB8|rcsb pdb:6LE5|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJX|rcsb pdb:6XQN|rcsb pdb:6XQO|reactome:R-HSA-8949215|reactome:R-HSA-8949664|rcsb pdb:6XJV	ensembl:ENSG00000165487(gene)|ensembl:ENST00000382374(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0051562"(negative regulation of mitochondrial calcium ion concentration)|go:"GO:1990246"(uniplex complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR039800|rcsb pdb:6AGH|rcsb pdb:6IIH|rcsb pdb:6K7Y|rcsb pdb:6LB7|rcsb pdb:6LB8|rcsb pdb:6LE5|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|rcsb pdb:6XQN|rcsb pdb:6XQO|reactome:R-HSA-8949215|reactome:R-HSA-8949664|refseq:NP_689939.1	intact:EBI-25747994(see-also)	-	-	figure legend:Supp. Fig 1C, 1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2020/07/02	2020/07/06	rogid:ieoktRyh6dR8RvLctKOhbT84qPU9606	rogid:qj7nAE+DvoW/RWlr4VWGSbhS6Mc9606	rigid:HXMbQmlBBO7pUB5gtCPtIb+Wers	false	mutation with complex effect:126-126,129-129|mutation with no effect:126-126,129-129|mutation with no effect:126-126,129-129,114-114|mutation with complex effect:126-126,129-129,114-114,121-121|flag tag:c-c|mutation with no effect:114-114|mutation with no effect:126-126|mutation with no effect:129-129	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BPX6	uniprotkb:Q8NE86	intact:EBI-2371996|uniprotkb:O75785|uniprotkb:Q9H9N6|uniprotkb:Q9UFX0|uniprotkb:A8MV96|uniprotkb:B3KN20|uniprotkb:B4DJH9|uniprotkb:B4DPI1|uniprotkb:B5MBY3|uniprotkb:D3YTJ3|ensembl:ENSP00000354415	intact:EBI-6552124|ensembl:ENSP00000362144|uniprotkb:B2RDF3|uniprotkb:B3KXV7|uniprotkb:Q96FL3	psi-mi:micu1_human(display_long)|uniprotkb:MICU1(gene name)|psi-mi:MICU1(display_short)|uniprotkb:Calcium-binding atopy-related autoantigen 1(gene name synonym)|uniprotkb:CBARA1(gene name synonym)|uniprotkb:CALC(gene name synonym)|uniprotkb:Atopy-related autoantigen CALC(gene name synonym)	psi-mi:mcu_human(display_long)|uniprotkb:MCU(gene name)|psi-mi:MCU(display_short)|uniprotkb:C10orf42(gene name synonym)|uniprotkb:CCDC109A(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 109A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Fan et al. (2020)	pubmed:32494073|imex:IM-28151	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25747953|imex:IM-28151-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001182447.1|refseq:NP_001182448.1|refseq:NP_006068.2|dip:DIP-53438N|ensembl:ENSG00000107745(gene)|ensembl:ENST00000361114(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006952"(defense response)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0070509"(calcium ion import)|go:"GO:1900069"(regulation of cellular hyperosmotic salinity response)|go:"GO:1990246"(uniplex complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR039800|rcsb pdb:4NSC|rcsb pdb:4NSD|rcsb pdb:6K7Y|rcsb pdb:6LB7|rcsb pdb:6LB8|rcsb pdb:6LE5|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJX|rcsb pdb:6XQN|rcsb pdb:6XQO|reactome:R-HSA-8949215|reactome:R-HSA-8949664|rcsb pdb:6XJV	go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1990246"(uniplex complex)|interpro:IPR006769(Protein of unknown function DUF607)|interpro:IPR039055|rcsb pdb:4XSJ|rcsb pdb:4XTB|rcsb pdb:5BZ6|rcsb pdb:5KUE|rcsb pdb:5KUG|rcsb pdb:5KUI|rcsb pdb:5KUJ|rcsb pdb:6JG0|rcsb pdb:6K7X|rcsb pdb:6K7Y|rcsb pdb:6KVX|rcsb pdb:6O58|rcsb pdb:6O5B|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|reactome:R-HSA-8949215|reactome:R-HSA-8949664|go:"GO:0019722"(calcium-mediated signaling)|ensembl:ENSG00000156026(gene)|ensembl:ENST00000373053(transcript)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0015292"(uniporter activity)|refseq:NP_001257608.1|refseq:NP_001257609.1|refseq:NP_612366.1|dip:DIP-60468N	intact:EBI-25747994(see-also)	-	-	figure legend:Supp. Fig 1C, 1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2020/07/02	2020/07/06	rogid:ieoktRyh6dR8RvLctKOhbT84qPU9606	rogid:t2fSATmrk7IEC0nMpquAoPB3CHs9606	rigid:HXMbQmlBBO7pUB5gtCPtIb+Wers	false	mutation with complex effect:126-126,129-129|mutation with no effect:126-126,129-129|mutation with no effect:126-126,129-129,114-114|mutation with complex effect:126-126,129-129,114-114,121-121|flag tag:c-c|mutation with no effect:114-114|mutation with no effect:126-126|mutation with no effect:129-129	tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8IYU8	uniprotkb:Q9BPX6	intact:EBI-3197790|ensembl:ENSP00000371811|uniprotkb:Q8N0T6|uniprotkb:Q8NAX8	intact:EBI-2371996|uniprotkb:O75785|uniprotkb:Q9H9N6|uniprotkb:Q9UFX0|uniprotkb:A8MV96|uniprotkb:B3KN20|uniprotkb:B4DJH9|uniprotkb:B4DPI1|uniprotkb:B5MBY3|uniprotkb:D3YTJ3|ensembl:ENSP00000354415	psi-mi:micu2_human(display_long)|uniprotkb:MICU2(gene name)|psi-mi:MICU2(display_short)|uniprotkb:EF-hand domain-containing family member A1(gene name synonym)|uniprotkb:EFHA1(gene name synonym)	psi-mi:micu1_human(display_long)|uniprotkb:MICU1(gene name)|psi-mi:MICU1(display_short)|uniprotkb:Calcium-binding atopy-related autoantigen 1(gene name synonym)|uniprotkb:CBARA1(gene name synonym)|uniprotkb:CALC(gene name synonym)|uniprotkb:Atopy-related autoantigen CALC(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Fan et al. (2020)	pubmed:32494073|imex:IM-28151	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25747994|imex:IM-28151-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000165487(gene)|ensembl:ENST00000382374(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0051562"(negative regulation of mitochondrial calcium ion concentration)|go:"GO:1990246"(uniplex complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR039800|rcsb pdb:6AGH|rcsb pdb:6IIH|rcsb pdb:6K7Y|rcsb pdb:6LB7|rcsb pdb:6LB8|rcsb pdb:6LE5|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|rcsb pdb:6XQN|rcsb pdb:6XQO|reactome:R-HSA-8949215|reactome:R-HSA-8949664|refseq:NP_689939.1	refseq:NP_001182447.1|refseq:NP_001182448.1|refseq:NP_006068.2|dip:DIP-53438N|ensembl:ENSG00000107745(gene)|ensembl:ENST00000361114(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006952"(defense response)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0070509"(calcium ion import)|go:"GO:1900069"(regulation of cellular hyperosmotic salinity response)|go:"GO:1990246"(uniplex complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR039800|rcsb pdb:4NSC|rcsb pdb:4NSD|rcsb pdb:6K7Y|rcsb pdb:6LB7|rcsb pdb:6LB8|rcsb pdb:6LE5|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJX|rcsb pdb:6XQN|rcsb pdb:6XQO|reactome:R-HSA-8949215|reactome:R-HSA-8949664|rcsb pdb:6XJV	intact:EBI-25747953(see-also)	-	-	figure legend:Supp. Fig 1F|comment:The inhibitory effect of the MICU2 Arg352Glu mutant was only examined in a MICU1 Cys463Ser background|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2020/07/02	2020/07/06	rogid:qj7nAE+DvoW/RWlr4VWGSbhS6Mc9606	rogid:ieoktRyh6dR8RvLctKOhbT84qPU9606	rigid:QgBUPv87WvTQeepSTaccY6umNAc	false	mutation disrupting interaction strength:352-352	flag tag:c-c|mutation with no effect:463-463	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8NE86	uniprotkb:Q9H4I9	intact:EBI-6552124|ensembl:ENSP00000362144|uniprotkb:B2RDF3|uniprotkb:B3KXV7|uniprotkb:Q96FL3	intact:EBI-11908005|ensembl:ENSP00000327467|ensembl:ENSP00000459368|ensembl:ENSP00000475471|ensembl:ENSP00000485029|uniprotkb:B2R5D1|uniprotkb:Q8TAB9	psi-mi:mcu_human(display_long)|uniprotkb:MCU(gene name)|psi-mi:MCU(display_short)|uniprotkb:C10orf42(gene name synonym)|uniprotkb:CCDC109A(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 109A(gene name synonym)	psi-mi:emre_human(display_long)|uniprotkb:SMDT1(gene name)|psi-mi:SMDT1(display_short)|uniprotkb:C22orf32(gene name synonym)|uniprotkb:EMRE(gene name synonym)|uniprotkb:Single-pass membrane protein with aspartate-rich tail 1, mitochondrial(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Fan et al. (2020)	pubmed:32494073|imex:IM-28151	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25748061|imex:IM-28151-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1990246"(uniplex complex)|interpro:IPR006769(Protein of unknown function DUF607)|interpro:IPR039055|rcsb pdb:4XSJ|rcsb pdb:4XTB|rcsb pdb:5BZ6|rcsb pdb:5KUE|rcsb pdb:5KUG|rcsb pdb:5KUI|rcsb pdb:5KUJ|rcsb pdb:6JG0|rcsb pdb:6K7X|rcsb pdb:6K7Y|rcsb pdb:6KVX|rcsb pdb:6O58|rcsb pdb:6O5B|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|reactome:R-HSA-8949215|reactome:R-HSA-8949664|go:"GO:0019722"(calcium-mediated signaling)|ensembl:ENSG00000156026(gene)|ensembl:ENST00000373053(transcript)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0015292"(uniporter activity)|refseq:NP_001257608.1|refseq:NP_001257609.1|refseq:NP_612366.1|dip:DIP-60468N	ensembl:ENSG00000183172(gene)|ensembl:ENSG00000272835(gene)|ensembl:ENSG00000272901(gene)|ensembl:ENSG00000274112(gene)|ensembl:ENST00000331479(transcript)|ensembl:ENST00000571525(transcript)|ensembl:ENST00000607293(transcript)|ensembl:ENST00000615504(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:1990246"(uniplex complex)|interpro:IPR018782|rcsb pdb:6K7X|rcsb pdb:6K7Y|rcsb pdb:6O58|rcsb pdb:6O5B|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|reactome:R-HSA-8949215|reactome:R-HSA-8949664|refseq:NP_201575.3|refseq:XP_011528811.1	intact:EBI-25747994(see-also)	-	-	figure legend:Supp. Figs 1E, 7A, 7B|comment:Interaction observed in low calcium conditions|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2020/07/02	2020/07/06	rogid:t2fSATmrk7IEC0nMpquAoPB3CHs9606	rogid:GzSAPUzq7COaeqDVh6pJkbd2eCE9606	rigid:zs7tR8YoOfwmGjnWPoQDtWB/apU	false	tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q8NE86	uniprotkb:Q8IYU8	intact:EBI-6552124|ensembl:ENSP00000362144|uniprotkb:B2RDF3|uniprotkb:B3KXV7|uniprotkb:Q96FL3	intact:EBI-3197790|ensembl:ENSP00000371811|uniprotkb:Q8N0T6|uniprotkb:Q8NAX8	psi-mi:mcu_human(display_long)|uniprotkb:MCU(gene name)|psi-mi:MCU(display_short)|uniprotkb:C10orf42(gene name synonym)|uniprotkb:CCDC109A(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 109A(gene name synonym)	psi-mi:micu2_human(display_long)|uniprotkb:MICU2(gene name)|psi-mi:MICU2(display_short)|uniprotkb:EF-hand domain-containing family member A1(gene name synonym)|uniprotkb:EFHA1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Fan et al. (2020)	pubmed:32494073|imex:IM-28151	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25748061|imex:IM-28151-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1990246"(uniplex complex)|interpro:IPR006769(Protein of unknown function DUF607)|interpro:IPR039055|rcsb pdb:4XSJ|rcsb pdb:4XTB|rcsb pdb:5BZ6|rcsb pdb:5KUE|rcsb pdb:5KUG|rcsb pdb:5KUI|rcsb pdb:5KUJ|rcsb pdb:6JG0|rcsb pdb:6K7X|rcsb pdb:6K7Y|rcsb pdb:6KVX|rcsb pdb:6O58|rcsb pdb:6O5B|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|reactome:R-HSA-8949215|reactome:R-HSA-8949664|go:"GO:0019722"(calcium-mediated signaling)|ensembl:ENSG00000156026(gene)|ensembl:ENST00000373053(transcript)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0015292"(uniporter activity)|refseq:NP_001257608.1|refseq:NP_001257609.1|refseq:NP_612366.1|dip:DIP-60468N	ensembl:ENSG00000165487(gene)|ensembl:ENST00000382374(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0051562"(negative regulation of mitochondrial calcium ion concentration)|go:"GO:1990246"(uniplex complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR039800|rcsb pdb:6AGH|rcsb pdb:6IIH|rcsb pdb:6K7Y|rcsb pdb:6LB7|rcsb pdb:6LB8|rcsb pdb:6LE5|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|rcsb pdb:6XQN|rcsb pdb:6XQO|reactome:R-HSA-8949215|reactome:R-HSA-8949664|refseq:NP_689939.1	intact:EBI-25747994(see-also)	-	-	figure legend:Supp. Figs 1E, 7A, 7B|comment:Interaction observed in low calcium conditions|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2020/07/02	2020/07/06	rogid:t2fSATmrk7IEC0nMpquAoPB3CHs9606	rogid:qj7nAE+DvoW/RWlr4VWGSbhS6Mc9606	rigid:zs7tR8YoOfwmGjnWPoQDtWB/apU	false	tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8NE86	uniprotkb:Q9BPX6	intact:EBI-6552124|ensembl:ENSP00000362144|uniprotkb:B2RDF3|uniprotkb:B3KXV7|uniprotkb:Q96FL3	intact:EBI-2371996|uniprotkb:O75785|uniprotkb:Q9H9N6|uniprotkb:Q9UFX0|uniprotkb:A8MV96|uniprotkb:B3KN20|uniprotkb:B4DJH9|uniprotkb:B4DPI1|uniprotkb:B5MBY3|uniprotkb:D3YTJ3|ensembl:ENSP00000354415	psi-mi:mcu_human(display_long)|uniprotkb:MCU(gene name)|psi-mi:MCU(display_short)|uniprotkb:C10orf42(gene name synonym)|uniprotkb:CCDC109A(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 109A(gene name synonym)	psi-mi:micu1_human(display_long)|uniprotkb:MICU1(gene name)|psi-mi:MICU1(display_short)|uniprotkb:Calcium-binding atopy-related autoantigen 1(gene name synonym)|uniprotkb:CBARA1(gene name synonym)|uniprotkb:CALC(gene name synonym)|uniprotkb:Atopy-related autoantigen CALC(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Fan et al. (2020)	pubmed:32494073|imex:IM-28151	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25748061|imex:IM-28151-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1990246"(uniplex complex)|interpro:IPR006769(Protein of unknown function DUF607)|interpro:IPR039055|rcsb pdb:4XSJ|rcsb pdb:4XTB|rcsb pdb:5BZ6|rcsb pdb:5KUE|rcsb pdb:5KUG|rcsb pdb:5KUI|rcsb pdb:5KUJ|rcsb pdb:6JG0|rcsb pdb:6K7X|rcsb pdb:6K7Y|rcsb pdb:6KVX|rcsb pdb:6O58|rcsb pdb:6O5B|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|reactome:R-HSA-8949215|reactome:R-HSA-8949664|go:"GO:0019722"(calcium-mediated signaling)|ensembl:ENSG00000156026(gene)|ensembl:ENST00000373053(transcript)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0015292"(uniporter activity)|refseq:NP_001257608.1|refseq:NP_001257609.1|refseq:NP_612366.1|dip:DIP-60468N	refseq:NP_001182447.1|refseq:NP_001182448.1|refseq:NP_006068.2|dip:DIP-53438N|ensembl:ENSG00000107745(gene)|ensembl:ENST00000361114(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006952"(defense response)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0070509"(calcium ion import)|go:"GO:1900069"(regulation of cellular hyperosmotic salinity response)|go:"GO:1990246"(uniplex complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR039800|rcsb pdb:4NSC|rcsb pdb:4NSD|rcsb pdb:6K7Y|rcsb pdb:6LB7|rcsb pdb:6LB8|rcsb pdb:6LE5|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJX|rcsb pdb:6XQN|rcsb pdb:6XQO|reactome:R-HSA-8949215|reactome:R-HSA-8949664|rcsb pdb:6XJV	intact:EBI-25747994(see-also)	-	-	figure legend:Supp. Figs 1E, 7A, 7B|comment:Interaction observed in low calcium conditions|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2020/07/02	2020/07/06	rogid:t2fSATmrk7IEC0nMpquAoPB3CHs9606	rogid:ieoktRyh6dR8RvLctKOhbT84qPU9606	rigid:zs7tR8YoOfwmGjnWPoQDtWB/apU	false	tag:c-c	flag tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9H4I9	uniprotkb:Q8NE86	intact:EBI-11908005|ensembl:ENSP00000327467|ensembl:ENSP00000459368|ensembl:ENSP00000475471|ensembl:ENSP00000485029|uniprotkb:B2R5D1|uniprotkb:Q8TAB9	intact:EBI-6552124|ensembl:ENSP00000362144|uniprotkb:B2RDF3|uniprotkb:B3KXV7|uniprotkb:Q96FL3	psi-mi:emre_human(display_long)|uniprotkb:SMDT1(gene name)|psi-mi:SMDT1(display_short)|uniprotkb:C22orf32(gene name synonym)|uniprotkb:EMRE(gene name synonym)|uniprotkb:Single-pass membrane protein with aspartate-rich tail 1, mitochondrial(gene name synonym)	psi-mi:mcu_human(display_long)|uniprotkb:MCU(gene name)|psi-mi:MCU(display_short)|uniprotkb:C10orf42(gene name synonym)|uniprotkb:CCDC109A(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 109A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Fan et al. (2020)	pubmed:32494073|imex:IM-28151	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25748102|imex:IM-28151-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000183172(gene)|ensembl:ENSG00000272835(gene)|ensembl:ENSG00000272901(gene)|ensembl:ENSG00000274112(gene)|ensembl:ENST00000331479(transcript)|ensembl:ENST00000571525(transcript)|ensembl:ENST00000607293(transcript)|ensembl:ENST00000615504(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:1990246"(uniplex complex)|interpro:IPR018782|rcsb pdb:6K7X|rcsb pdb:6K7Y|rcsb pdb:6O58|rcsb pdb:6O5B|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|reactome:R-HSA-8949215|reactome:R-HSA-8949664|refseq:NP_201575.3|refseq:XP_011528811.1	go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1990246"(uniplex complex)|interpro:IPR006769(Protein of unknown function DUF607)|interpro:IPR039055|rcsb pdb:4XSJ|rcsb pdb:4XTB|rcsb pdb:5BZ6|rcsb pdb:5KUE|rcsb pdb:5KUG|rcsb pdb:5KUI|rcsb pdb:5KUJ|rcsb pdb:6JG0|rcsb pdb:6K7X|rcsb pdb:6K7Y|rcsb pdb:6KVX|rcsb pdb:6O58|rcsb pdb:6O5B|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|reactome:R-HSA-8949215|reactome:R-HSA-8949664|go:"GO:0019722"(calcium-mediated signaling)|ensembl:ENSG00000156026(gene)|ensembl:ENST00000373053(transcript)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0015292"(uniporter activity)|refseq:NP_001257608.1|refseq:NP_001257609.1|refseq:NP_612366.1|dip:DIP-60468N	intact:EBI-25747994(see-also)	-	-	figure legend:Supp. Fig 1E, 7A, 7B|comment:"Interaction observed in high (2mM) calcium conditions."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2020/07/02	2020/07/06	rogid:GzSAPUzq7COaeqDVh6pJkbd2eCE9606	rogid:t2fSATmrk7IEC0nMpquAoPB3CHs9606	rigid:iypHY/15T0ROCTwYh7EF3z/w6Gc	false	sufficient binding region:1-95	tag:c-c	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9H4I9	uniprotkb:Q8NE86	intact:EBI-11908005|ensembl:ENSP00000327467|ensembl:ENSP00000459368|ensembl:ENSP00000475471|ensembl:ENSP00000485029|uniprotkb:B2R5D1|uniprotkb:Q8TAB9	intact:EBI-6552124|ensembl:ENSP00000362144|uniprotkb:B2RDF3|uniprotkb:B3KXV7|uniprotkb:Q96FL3	psi-mi:emre_human(display_long)|uniprotkb:SMDT1(gene name)|psi-mi:SMDT1(display_short)|uniprotkb:C22orf32(gene name synonym)|uniprotkb:EMRE(gene name synonym)|uniprotkb:Single-pass membrane protein with aspartate-rich tail 1, mitochondrial(gene name synonym)	psi-mi:mcu_human(display_long)|uniprotkb:MCU(gene name)|psi-mi:MCU(display_short)|uniprotkb:C10orf42(gene name synonym)|uniprotkb:CCDC109A(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 109A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Fan et al. (2020)	pubmed:32494073|imex:IM-28151	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25748118|imex:IM-28151-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000183172(gene)|ensembl:ENSG00000272835(gene)|ensembl:ENSG00000272901(gene)|ensembl:ENSG00000274112(gene)|ensembl:ENST00000331479(transcript)|ensembl:ENST00000571525(transcript)|ensembl:ENST00000607293(transcript)|ensembl:ENST00000615504(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:1990246"(uniplex complex)|interpro:IPR018782|rcsb pdb:6K7X|rcsb pdb:6K7Y|rcsb pdb:6O58|rcsb pdb:6O5B|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|reactome:R-HSA-8949215|reactome:R-HSA-8949664|refseq:NP_201575.3|refseq:XP_011528811.1	go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1990246"(uniplex complex)|interpro:IPR006769(Protein of unknown function DUF607)|interpro:IPR039055|rcsb pdb:4XSJ|rcsb pdb:4XTB|rcsb pdb:5BZ6|rcsb pdb:5KUE|rcsb pdb:5KUG|rcsb pdb:5KUI|rcsb pdb:5KUJ|rcsb pdb:6JG0|rcsb pdb:6K7X|rcsb pdb:6K7Y|rcsb pdb:6KVX|rcsb pdb:6O58|rcsb pdb:6O5B|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|reactome:R-HSA-8949215|reactome:R-HSA-8949664|go:"GO:0019722"(calcium-mediated signaling)|ensembl:ENSG00000156026(gene)|ensembl:ENST00000373053(transcript)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0015292"(uniporter activity)|refseq:NP_001257608.1|refseq:NP_001257609.1|refseq:NP_612366.1|dip:DIP-60468N	intact:EBI-25747994(see-also)	-	-	figure legend:Supp. Fig 1E, 7B|comment:"Charge-reversal of MICU1’s KKKKR sequence to QEQEQ (EQ) greatly weakens MICU1’s association with MCU although trace amounts of MCU remain associated with the complex. Interaction observed in high salt conditions, under low salt trace amounts of charged reversed MICU1 and also MICU2 were observed in the complex."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2020/07/02	2020/07/06	rogid:GzSAPUzq7COaeqDVh6pJkbd2eCE9606	rogid:t2fSATmrk7IEC0nMpquAoPB3CHs9606	rigid:iypHY/15T0ROCTwYh7EF3z/w6Gc	false	-	tag:c-c	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8NE86	uniprotkb:Q8IYU8	intact:EBI-6552124|ensembl:ENSP00000362144|uniprotkb:B2RDF3|uniprotkb:B3KXV7|uniprotkb:Q96FL3	intact:EBI-3197790|ensembl:ENSP00000371811|uniprotkb:Q8N0T6|uniprotkb:Q8NAX8	psi-mi:mcu_human(display_long)|uniprotkb:MCU(gene name)|psi-mi:MCU(display_short)|uniprotkb:C10orf42(gene name synonym)|uniprotkb:CCDC109A(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 109A(gene name synonym)	psi-mi:micu2_human(display_long)|uniprotkb:MICU2(gene name)|psi-mi:MICU2(display_short)|uniprotkb:EF-hand domain-containing family member A1(gene name synonym)|uniprotkb:EFHA1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Fan et al. (2020)	pubmed:32494073|imex:IM-28151	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25748248|imex:IM-28151-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1990246"(uniplex complex)|interpro:IPR006769(Protein of unknown function DUF607)|interpro:IPR039055|rcsb pdb:4XSJ|rcsb pdb:4XTB|rcsb pdb:5BZ6|rcsb pdb:5KUE|rcsb pdb:5KUG|rcsb pdb:5KUI|rcsb pdb:5KUJ|rcsb pdb:6JG0|rcsb pdb:6K7X|rcsb pdb:6K7Y|rcsb pdb:6KVX|rcsb pdb:6O58|rcsb pdb:6O5B|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|reactome:R-HSA-8949215|reactome:R-HSA-8949664|go:"GO:0019722"(calcium-mediated signaling)|ensembl:ENSG00000156026(gene)|ensembl:ENST00000373053(transcript)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0015292"(uniporter activity)|refseq:NP_001257608.1|refseq:NP_001257609.1|refseq:NP_612366.1|dip:DIP-60468N	ensembl:ENSG00000165487(gene)|ensembl:ENST00000382374(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0051562"(negative regulation of mitochondrial calcium ion concentration)|go:"GO:1990246"(uniplex complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR039800|rcsb pdb:6AGH|rcsb pdb:6IIH|rcsb pdb:6K7Y|rcsb pdb:6LB7|rcsb pdb:6LB8|rcsb pdb:6LE5|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|rcsb pdb:6XQN|rcsb pdb:6XQO|reactome:R-HSA-8949215|reactome:R-HSA-8949664|refseq:NP_689939.1	intact:EBI-25747994(see-also)	-	-	figure legend:Supp. Fig 7A|comment:Interaction observed in low calcium conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2020/07/02	2020/10/01	rogid:t2fSATmrk7IEC0nMpquAoPB3CHs9606	rogid:qj7nAE+DvoW/RWlr4VWGSbhS6Mc9606	rigid:9EnWUdPKfhIUHODk6oQFQKOcO5o	false	tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8NE86	uniprotkb:Q9H4I9	intact:EBI-6552124|ensembl:ENSP00000362144|uniprotkb:B2RDF3|uniprotkb:B3KXV7|uniprotkb:Q96FL3	intact:EBI-11908005|ensembl:ENSP00000327467|ensembl:ENSP00000459368|ensembl:ENSP00000475471|ensembl:ENSP00000485029|uniprotkb:B2R5D1|uniprotkb:Q8TAB9	psi-mi:mcu_human(display_long)|uniprotkb:MCU(gene name)|psi-mi:MCU(display_short)|uniprotkb:C10orf42(gene name synonym)|uniprotkb:CCDC109A(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 109A(gene name synonym)	psi-mi:emre_human(display_long)|uniprotkb:SMDT1(gene name)|psi-mi:SMDT1(display_short)|uniprotkb:C22orf32(gene name synonym)|uniprotkb:EMRE(gene name synonym)|uniprotkb:Single-pass membrane protein with aspartate-rich tail 1, mitochondrial(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Fan et al. (2020)	pubmed:32494073|imex:IM-28151	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25748248|imex:IM-28151-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1990246"(uniplex complex)|interpro:IPR006769(Protein of unknown function DUF607)|interpro:IPR039055|rcsb pdb:4XSJ|rcsb pdb:4XTB|rcsb pdb:5BZ6|rcsb pdb:5KUE|rcsb pdb:5KUG|rcsb pdb:5KUI|rcsb pdb:5KUJ|rcsb pdb:6JG0|rcsb pdb:6K7X|rcsb pdb:6K7Y|rcsb pdb:6KVX|rcsb pdb:6O58|rcsb pdb:6O5B|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|reactome:R-HSA-8949215|reactome:R-HSA-8949664|go:"GO:0019722"(calcium-mediated signaling)|ensembl:ENSG00000156026(gene)|ensembl:ENST00000373053(transcript)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0015292"(uniporter activity)|refseq:NP_001257608.1|refseq:NP_001257609.1|refseq:NP_612366.1|dip:DIP-60468N	ensembl:ENSG00000183172(gene)|ensembl:ENSG00000272835(gene)|ensembl:ENSG00000272901(gene)|ensembl:ENSG00000274112(gene)|ensembl:ENST00000331479(transcript)|ensembl:ENST00000571525(transcript)|ensembl:ENST00000607293(transcript)|ensembl:ENST00000615504(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:1990246"(uniplex complex)|interpro:IPR018782|rcsb pdb:6K7X|rcsb pdb:6K7Y|rcsb pdb:6O58|rcsb pdb:6O5B|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|reactome:R-HSA-8949215|reactome:R-HSA-8949664|refseq:NP_201575.3|refseq:XP_011528811.1	intact:EBI-25747994(see-also)	-	-	figure legend:Supp. Fig 7A|comment:Interaction observed in low calcium conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2020/07/02	2020/10/01	rogid:t2fSATmrk7IEC0nMpquAoPB3CHs9606	rogid:GzSAPUzq7COaeqDVh6pJkbd2eCE9606	rigid:9EnWUdPKfhIUHODk6oQFQKOcO5o	false	tag:c-c	sufficient binding region:1-95	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q8IYU8	uniprotkb:Q9BPX6	intact:EBI-3197790|ensembl:ENSP00000371811|uniprotkb:Q8N0T6|uniprotkb:Q8NAX8	intact:EBI-2371996|uniprotkb:O75785|uniprotkb:Q9H9N6|uniprotkb:Q9UFX0|uniprotkb:A8MV96|uniprotkb:B3KN20|uniprotkb:B4DJH9|uniprotkb:B4DPI1|uniprotkb:B5MBY3|uniprotkb:D3YTJ3|ensembl:ENSP00000354415	psi-mi:micu2_human(display_long)|uniprotkb:MICU2(gene name)|psi-mi:MICU2(display_short)|uniprotkb:EF-hand domain-containing family member A1(gene name synonym)|uniprotkb:EFHA1(gene name synonym)	psi-mi:micu1_human(display_long)|uniprotkb:MICU1(gene name)|psi-mi:MICU1(display_short)|uniprotkb:Calcium-binding atopy-related autoantigen 1(gene name synonym)|uniprotkb:CBARA1(gene name synonym)|uniprotkb:CALC(gene name synonym)|uniprotkb:Atopy-related autoantigen CALC(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Fan et al. (2020)	pubmed:32494073|imex:IM-28151	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26360832|imex:IM-28151-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000165487(gene)|ensembl:ENST00000382374(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0051562"(negative regulation of mitochondrial calcium ion concentration)|go:"GO:1990246"(uniplex complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR039800|rcsb pdb:6AGH|rcsb pdb:6IIH|rcsb pdb:6K7Y|rcsb pdb:6LB7|rcsb pdb:6LB8|rcsb pdb:6LE5|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|rcsb pdb:6XQN|rcsb pdb:6XQO|reactome:R-HSA-8949215|reactome:R-HSA-8949664|refseq:NP_689939.1	refseq:NP_001182447.1|refseq:NP_001182448.1|refseq:NP_006068.2|dip:DIP-53438N|ensembl:ENSG00000107745(gene)|ensembl:ENST00000361114(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006952"(defense response)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0070509"(calcium ion import)|go:"GO:1900069"(regulation of cellular hyperosmotic salinity response)|go:"GO:1990246"(uniplex complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR039800|rcsb pdb:4NSC|rcsb pdb:4NSD|rcsb pdb:6K7Y|rcsb pdb:6LB7|rcsb pdb:6LB8|rcsb pdb:6LE5|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJX|rcsb pdb:6XQN|rcsb pdb:6XQO|reactome:R-HSA-8949215|reactome:R-HSA-8949664|rcsb pdb:6XJV	intact:EBI-25747953(see-also)	-	-	figure legend:Supp. Fig 1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2020/07/02	2020/09/28	rogid:qj7nAE+DvoW/RWlr4VWGSbhS6Mc9606	rogid:ieoktRyh6dR8RvLctKOhbT84qPU9606	rigid:QgBUPv87WvTQeepSTaccY6umNAc	false	-	flag tag:c-c|sufficient binding region:1-444	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)