#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B chebi:"CHEBI:28808" uniprotkb:P11226 intact:EBI-25613000|chebi:"CHEBI:6684"|chebi:"CHEBI:25159" intact:EBI-5325353|ensembl:ENSP00000363079|ensembl:ENSP00000502615|ensembl:ENSP00000502789|uniprotkb:Q4VB12|uniprotkb:Q4VB13|uniprotkb:Q86SI4|uniprotkb:Q96KE4|uniprotkb:Q96TF7|uniprotkb:Q96TF8|uniprotkb:Q96TF9|uniprotkb:Q4VB14|uniprotkb:Q5SQS3 psi-mi:mannan(display_short)|psi-mi:"CHEBI:28808"(display_long)|intact:Mannan(synonym)|intact:mannans(synonym)|intact:Mannoglycan(synonym)|intact:mannan(iupac name) psi-mi:mbl2_human(display_long)|uniprotkb:MBL2(gene name)|psi-mi:MBL2(display_short)|uniprotkb:COLEC1(gene name synonym)|uniprotkb:MBL(gene name synonym)|uniprotkb:Collectin-1(gene name synonym)|uniprotkb:MBP1(gene name synonym)|uniprotkb:Mannan-binding protein(gene name synonym)|uniprotkb:Mannose-binding lectin(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Talsma et al. (2019) imex:IM-29288|pubmed:32425936 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-27104959|imex:IM-29288-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - ensembl:ENSG00000165471(gene)|ensembl:ENST00000373968(transcript)|ensembl:ENST00000674931(transcript)|ensembl:ENST00000675947(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008228"(opsonization)|go:"GO:0009986"(cell surface)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048525"(negative regulation of viral process)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001304(C-type lectin)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016186(C-type lectin-like)|refseq:XP_011538118.1|interpro:IPR018378|interpro:IPR033990|interpro:IPR037570|rcsb pdb:1HUP|interpro:IPR016187(C-type lectin fold)|reactome:R-HSA-166662|reactome:R-HSA-166663|refseq:NP_000233.1|refseq:XP_006717924.1|dip:DIP-61381N - - - figure legend:2 A/B|comment:None of the heparin preparations tested could inhibit MBL binding to mannan.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/12/17 2021/10/12 - rogid:uo0RM88uw3otObIVnOhUcOfW8yo9606 - false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) chebi:"CHEBI:28304" uniprotkb:O00187 intact:EBI-1379423 intact:EBI-7965040|uniprotkb:Q9UMV3|intact:MINT-7970114|uniprotkb:Q9ULC7|uniprotkb:Q9Y270|uniprotkb:A8MWJ2|uniprotkb:O75754|uniprotkb:Q96QG4|uniprotkb:Q9UBP3|uniprotkb:Q5TEQ5|uniprotkb:Q5TER0|uniprotkb:Q9H498|uniprotkb:Q9UC48|uniprotkb:A8K458|uniprotkb:Q9H499|uniprotkb:Q9BZH0|ensembl:ENSP00000383690 psi-mi:heparin(display_short)|psi-mi:"CHEBI:28304"(display_long) psi-mi:masp2_human(display_long)|uniprotkb:MASP2(gene name)|psi-mi:MASP2(display_short)|uniprotkb:Mannose-binding protein-associated serine protease 2(gene name synonym)|uniprotkb:MBL-associated serine protease 2(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Talsma et al. (2019) imex:IM-29288|pubmed:32425936 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-27105013|imex:IM-29288-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:NP_631947.1|refseq:NP_006601.2|ensembl:ENSG00000009724(gene)|ensembl:ENST00000400897(transcript)|go:"GO:0001855"(complement component C4b binding)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008233"(peptidase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000859(CUB)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018097|interpro:IPR033116|interpro:IPR035914|interpro:IPR035976|interpro:IPR037571|interpro:IPR043504|rcsb pdb:1Q3X|rcsb pdb:1SZB|rcsb pdb:1ZJK|rcsb pdb:3TVJ|rcsb pdb:4FXG|rcsb pdb:5JPM|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086 - - comment:mint figure legend:5A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/12/17 2021/10/13 - rogid:S48IDwjdZ8M6vIJD6iM0XplSN609606 - false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) chebi:"CHEBI:28304" uniprotkb:O00187-1 intact:EBI-1379423 intact:EBI-26357096|ensembl:ENSP00000383690 psi-mi:heparin(display_short)|psi-mi:"CHEBI:28304"(display_long) psi-mi:o00187-1(display_long)|uniprotkb:MBL-associated serine protease 2(gene name synonym)|uniprotkb:Mannose-binding protein-associated serine protease 2(gene name synonym)|uniprotkb:MASP2(gene name)|psi-mi:MASP2(display_short) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Talsma et al. (2019) imex:IM-29288|pubmed:32425936 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-27105023|imex:IM-29288-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - ensembl:ENST00000400897(transcript)|ensembl:ENSG00000009724(gene)|intact:EBI-7965040(isoform-parent) - - - figure legend:4B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/12/17 2021/10/13 - rogid:S48IDwjdZ8M6vIJD6iM0XplSN609606 - false - sufficient binding region:287-686 - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) chebi:"CHEBI:28304" uniprotkb:O00187-1 intact:EBI-1379423 intact:EBI-26357096|ensembl:ENSP00000383690 psi-mi:heparin(display_short)|psi-mi:"CHEBI:28304"(display_long) psi-mi:o00187-1(display_long)|uniprotkb:MBL-associated serine protease 2(gene name synonym)|uniprotkb:Mannose-binding protein-associated serine protease 2(gene name synonym)|uniprotkb:MASP2(gene name)|psi-mi:MASP2(display_short) psi-mi:"MI:0107"(surface plasmon resonance) Talsma et al. (2019) imex:IM-29288|pubmed:32425936 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-27104971|imex:IM-29288-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - ensembl:ENST00000400897(transcript)|ensembl:ENSG00000009724(gene)|intact:EBI-7965040(isoform-parent) - - - figure legend:3, Supp.figure 1|comment:"MASP-2 showed similar affinity for the 6 kDa heparin and the 15 kDa heparin and HS (Heparan sulphate)."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:2.0x10^-6 ~0.5(molar) 2020/12/17 2021/10/13 - rogid:S48IDwjdZ8M6vIJD6iM0XplSN609606 - false biotin tag:?-? sufficient binding region:287-686 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:28815" uniprotkb:O00187-1 intact:EBI-2566501 intact:EBI-26357096|ensembl:ENSP00000383690 psi-mi:heparan_sulfate(display_short)|psi-mi:"CHEBI:28815"(display_long) psi-mi:o00187-1(display_long)|uniprotkb:MBL-associated serine protease 2(gene name synonym)|uniprotkb:Mannose-binding protein-associated serine protease 2(gene name synonym)|uniprotkb:MASP2(gene name)|psi-mi:MASP2(display_short) psi-mi:"MI:0107"(surface plasmon resonance) Talsma et al. (2019) imex:IM-29288|pubmed:32425936 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-27105003|imex:IM-29288-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) matrixdb:GAG_2(source reference) ensembl:ENST00000400897(transcript)|ensembl:ENSG00000009724(gene)|intact:EBI-7965040(isoform-parent) - - - figure legend:3C, Supp.figure 1|comment:"MASP-2 showed similar affinity for the 6 kDa heparin and the 15 kDa heparin and HS (Heparan sulphate)."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:2.0x10^-6(molar) 2020/12/17 2021/10/13 - rogid:S48IDwjdZ8M6vIJD6iM0XplSN609606 - false biotin tag:?-? sufficient binding region:287-686 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:28304" chebi:"CHEBI:132213" intact:EBI-1379423 intact:EBI-11783287 psi-mi:heparin(display_short)|psi-mi:"CHEBI:28304"(display_long) psi-mi:heparin-dp4(display_short)|psi-mi:"CHEBI:132213"(display_long) psi-mi:"MI:0107"(surface plasmon resonance) Talsma et al. (2019) imex:IM-29288|pubmed:32425936 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-27105059|imex:IM-29288-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0941"(competitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0328"(small molecule) - - - - - figure legend:3D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/12/17 2021/10/13 - - - false biotin tag:?-? - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:28304" uniprotkb:O00187-1 intact:EBI-1379423 intact:EBI-26357096|ensembl:ENSP00000383690 psi-mi:heparin(display_short)|psi-mi:"CHEBI:28304"(display_long) psi-mi:o00187-1(display_long)|uniprotkb:MBL-associated serine protease 2(gene name synonym)|uniprotkb:Mannose-binding protein-associated serine protease 2(gene name synonym)|uniprotkb:MASP2(gene name)|psi-mi:MASP2(display_short) psi-mi:"MI:0107"(surface plasmon resonance) Talsma et al. (2019) imex:IM-29288|pubmed:32425936 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-27105059|imex:IM-29288-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - ensembl:ENST00000400897(transcript)|ensembl:ENSG00000009724(gene)|intact:EBI-7965040(isoform-parent) - - - figure legend:3D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/12/17 2021/10/13 - rogid:S48IDwjdZ8M6vIJD6iM0XplSN609606 - false biotin tag:?-? sufficient binding region:287-686 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:28815" uniprotkb:O00187 intact:EBI-2566501 intact:EBI-7965040|uniprotkb:Q9UMV3|intact:MINT-7970114|uniprotkb:Q9ULC7|uniprotkb:Q9Y270|uniprotkb:A8MWJ2|uniprotkb:O75754|uniprotkb:Q96QG4|uniprotkb:Q9UBP3|uniprotkb:Q5TEQ5|uniprotkb:Q5TER0|uniprotkb:Q9H498|uniprotkb:Q9UC48|uniprotkb:A8K458|uniprotkb:Q9H499|uniprotkb:Q9BZH0|ensembl:ENSP00000383690 psi-mi:heparan_sulfate(display_short)|psi-mi:"CHEBI:28815"(display_long) psi-mi:masp2_human(display_long)|uniprotkb:MASP2(gene name)|psi-mi:MASP2(display_short)|uniprotkb:Mannose-binding protein-associated serine protease 2(gene name synonym)|uniprotkb:MBL-associated serine protease 2(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Talsma et al. (2019) imex:IM-29288|pubmed:32425936 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-27105047|imex:IM-29288-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) matrixdb:GAG_2(source reference) refseq:NP_631947.1|refseq:NP_006601.2|ensembl:ENSG00000009724(gene)|ensembl:ENST00000400897(transcript)|go:"GO:0001855"(complement component C4b binding)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008233"(peptidase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000859(CUB)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018097|interpro:IPR033116|interpro:IPR035914|interpro:IPR035976|interpro:IPR037571|interpro:IPR043504|rcsb pdb:1Q3X|rcsb pdb:1SZB|rcsb pdb:1ZJK|rcsb pdb:3TVJ|rcsb pdb:4FXG|rcsb pdb:5JPM|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086 - - comment:mint figure legend:5,6|comment:MASP-2 and HS showed partial co localization in some basement membranes of vascular structures and in Bowman's capsule.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-kidney)|taxid:9606(Human kidney) - 2020/12/17 2021/11/11 - rogid:S48IDwjdZ8M6vIJD6iM0XplSN609606 - false - - - - psi-mi:"MI:1198"(immunohistochemistry) psi-mi:"MI:1198"(immunohistochemistry)