#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P21333	uniprotkb:P59046	intact:EBI-350432|uniprotkb:Q8NF52|intact:EBI-1103234|ensembl:ENSP00000358866|uniprotkb:Q5HY53|uniprotkb:Q5HY55|uniprotkb:E9KL45	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:flna_human(display_long)|uniprotkb:FLNA(gene name)|psi-mi:FLNA(display_short)|uniprotkb:FLN(gene name synonym)|uniprotkb:FLN1(gene name synonym)|uniprotkb:Alpha-filamin(gene name synonym)|uniprotkb:Filamin-1(gene name synonym)|uniprotkb:Endothelial actin-binding protein(gene name synonym)|uniprotkb:Actin-binding protein 280(gene name synonym)|uniprotkb:Non-muscle filamin(gene name synonym)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499123|imex:IM-27886-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:1902396"(protein localization to bicellular tight junction)|refseq:NP_001104026.1|refseq:NP_001447.2|ensembl:ENSG00000196924(gene)|ensembl:ENST00000369850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097368"(establishment of Sertoli cell barrier)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:0046332"(SMAD binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016479"(negative regulation of transcription by RNA polymerase I)|go:"GO:0019900"(kinase binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030018"(Z disc)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031523"(Myb complex)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032432"(actin filament bundle)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034988"(Fc-gamma receptor I complex binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045296"(cadherin binding)|reactome:R-HSA-114608|reactome:R-HSA-430116|reactome:R-HSA-446353|reactome:R-HSA-5627123|reactome:R-HSA-8983711|rcsb pdb:6EW1|go:"GO:1905031"(regulation of membrane repolarization during cardiac muscle cell action potential)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR036872|interpro:IPR044801|mint:P21333|rcsb pdb:2AAV|rcsb pdb:2BP3|rcsb pdb:2BRQ|rcsb pdb:2J3S|rcsb pdb:2JF1|rcsb pdb:2K3T|rcsb pdb:2K7P|rcsb pdb:2K7Q|rcsb pdb:2MTP|rcsb pdb:2W0P|rcsb pdb:2WFN|rcsb pdb:3CNK|rcsb pdb:3HOC|rcsb pdb:3HOP|rcsb pdb:3HOR|rcsb pdb:3ISW|rcsb pdb:3RGH|rcsb pdb:4M9P|rcsb pdb:4P3W|rcsb pdb:5XR1|rcsb pdb:6D8C|go:"GO:1905000"(regulation of membrane repolarization during atrial cardiac muscle cell action potential)|dip:DIP-1136N	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/08	rogid:ZxGK5OSMy8cNsyt7Ax2KXb8bn9M9606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:4xLnOl6citrhEvtEhNf0FFMaqrE	false	-	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P02795	uniprotkb:P59046	intact:EBI-996616|uniprotkb:Q2HXR9|uniprotkb:Q53XT9|uniprotkb:Q14823|ensembl:ENSP00000245185	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:mt2_human(display_long)|uniprotkb:Metallothionein-II(gene name synonym)|uniprotkb:Metallothionein-2A(gene name synonym)|uniprotkb:MT2A(gene name)|psi-mi:MT2A(display_short)|uniprotkb:CES1(gene name synonym)|uniprotkb:MT2(gene name synonym)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499125|imex:IM-27886-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005944.1|ensembl:ENSG00000125148(gene)|ensembl:ENST00000245185(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0036018"(cellular response to erythropoietin)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071294"(cellular response to zinc ion)|interpro:IPR000006(Metallothionein, vertebrate)|interpro:IPR003019(Metallothionein superfamily, eukaryotic)|interpro:IPR017854(Metallothionein superfamily)|interpro:IPR018064|interpro:IPR023587|mint:P02795|rcsb pdb:1MHU|rcsb pdb:2MHU|go:"GO:0006882"(cellular zinc ion homeostasis)|reactome:R-HSA-877300|reactome:R-HSA-5661231|dip:DIP-35232N	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/08	rogid:3adUmT5As6Rn1isYoH+jMsFKEgU9606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:Yo4o8BFL1oZY/E3by1a8Xfrg3Ec	false	-	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q15038	uniprotkb:P59046	intact:EBI-724310|ensembl:ENSP00000394699|uniprotkb:E9PB45|uniprotkb:A8K254|uniprotkb:B4DDT5|uniprotkb:C9JA96|uniprotkb:C9JP84|uniprotkb:B4E1G3|uniprotkb:F8VU62	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:dazp2_human(display_long)|uniprotkb:Deleted in azoospermia-associated protein 2(gene name synonym)|uniprotkb:DAZAP2(gene name)|psi-mi:DAZAP2(display_short)|uniprotkb:KIAA0058(gene name synonym)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499143|imex:IM-27886-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000183283(gene)|ensembl:ENST00000412716(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0050699"(WW domain binding)|interpro:IPR022730|mint:Q15038|refseq:NP_001129736.1|refseq:NP_055579.1|ensembl:ENSP00000394699|ensembl:ENST00000425012|ensembl:ENSP00000408251|ensembl:ENST00000439799|ensembl:ENSP00000398804|ensembl:ENST00000449723|ensembl:ENSP00000412812|ensembl:ENST00000549555|ensembl:ENSP00000448051|ensembl:ENST00000549732|ensembl:ENSP00000446554|refseq:NP_001129741.1|refseq:NP_001129739.1|refseq:NP_001129740.1|refseq:NP_001129738.1	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/08	rogid:ASRqCZBG4q1U/y95PUSMKsgfm/g9606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:Q7tWXcHNE2k1k2XZrEKBSpHDiXE	false	-	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P25685	uniprotkb:P59046	intact:EBI-357034|ensembl:ENSP00000254322|uniprotkb:B4DX52	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:dnjb1_human(display_long)|uniprotkb:DNAJB1(gene name)|psi-mi:DNAJB1(display_short)|uniprotkb:DNAJ1(gene name synonym)|uniprotkb:HDJ1(gene name synonym)|uniprotkb:HSPF1(gene name synonym)|uniprotkb:Heat shock 40 kDa protein 1(gene name synonym)|uniprotkb:Human DnaJ protein 1(gene name synonym)|uniprotkb:DnaJ protein homolog 1(gene name synonym)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499141|imex:IM-27886-41	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-41180N|ensembl:ENSG00000132002(gene)|ensembl:ENST00000254322(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030900"(forebrain development)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|refseq:NP_006136.1|refseq:XP_006722796.1|refseq:NP_001287843.1|refseq:NP_001300893.1|refseq:XP_011526258.1|refseq:XP_006722797.1|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0061827"(sperm head)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR018253|interpro:IPR036869|mint:P25685|rcsb pdb:1HDJ|rcsb pdb:2QLD|rcsb pdb:3AGX|rcsb pdb:3AGY|rcsb pdb:3AGZ|rcsb pdb:4WB7|rcsb pdb:6BYR|rcsb pdb:6WJF|rcsb pdb:6WJG|rcsb pdb:6Z5N|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-5687128|interpro:IPR008971(HSP40/DnaJ peptide-binding)	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:TableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/08	rogid:8NJHM7hHFc+zqulNiUM9UMxT/ws9606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:DRCiMrsp6heG5M2fdLNOi3+jbo0	false	-	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P08571	uniprotkb:P59046	intact:EBI-3905196|uniprotkb:Q96L99|uniprotkb:Q53XT5|uniprotkb:Q9UNS3|uniprotkb:Q96FR6|ensembl:ENSP00000304236|ensembl:ENSP00000385519	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:cd14_human(display_long)|uniprotkb:CD14(gene name)|psi-mi:CD14(display_short)|uniprotkb:Myeloid cell-specific leucine-rich glycoprotein(gene name synonym)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499161|imex:IM-27886-61	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000582.1|refseq:NP_001035110.1|refseq:NP_001167575.1|refseq:NP_001167576.1|dip:DIP-1030N|ensembl:ENSG00000170458(gene)|ensembl:ENST00000302014(transcript)|ensembl:ENST00000401743(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001847"(opsonin receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009408"(response to heat)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0016019"(peptidoglycan immune receptor activity)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031362"(anchored component of external side of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071723"(lipopeptide binding)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:0071727"(cellular response to triacyl bacterial lipopeptide)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR016337(Monocyte differentiation antigen CD14)|interpro:IPR032675|rcsb pdb:4GLP|reactome:R-HSA-1236974|reactome:R-HSA-140534|reactome:R-HSA-166016|reactome:R-HSA-166020|reactome:R-HSA-166058|reactome:R-HSA-166166|reactome:R-HSA-168179|reactome:R-HSA-168188|reactome:R-HSA-2562578|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072|reactome:R-HSA-975163|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/08	rogid:MpfQfOF+t0EMlzBio2kyYeJU3hE9606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:3SpsQgFgS7R1mSp0xEhsfrHhiGM	false	-	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P17844	uniprotkb:P59046	intact:EBI-351962|uniprotkb:O75681|uniprotkb:Q53Y61|uniprotkb:B4DLW8|uniprotkb:E7ETL9|uniprotkb:B5BU21|uniprotkb:D3DU32|ensembl:ENSP00000225792|ensembl:ENSP00000403085|ensembl:ENSP00000463168|ensembl:ENSP00000464337|ensembl:ENSP00000504794	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:ddx5_human(display_long)|uniprotkb:HLR1(gene name synonym)|uniprotkb:DDX5(gene name)|psi-mi:DDX5(display_short)|uniprotkb:HELR(gene name synonym)|uniprotkb:G17P1(gene name synonym)|uniprotkb:DEAD box protein 5(gene name synonym)|uniprotkb:RNA helicase p68(gene name synonym)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499165|imex:IM-27886-81	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004387.1|refseq:NP_001307524.1|refseq:NP_001307525.1|dip:DIP-29844N|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012587(P68HR)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P17844|rcsb pdb:3FE2|rcsb pdb:4A4D|reactome:R-HSA-3899300|reactome:R-HSA-72163|reactome:R-HSA-9018519|reactome:R-HSA-9682706|reactome:R-HSA-9694686|ensembl:ENST00000225792(transcript)|ensembl:ENST00000450599(transcript)|ensembl:ENST00000577922(transcript)|ensembl:ENST00000585111(transcript)|ensembl:ENST00000676785(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009299"(mRNA transcription)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0035500"(MH2 domain binding)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0046332"(SMAD binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061614"(miRNA transcription)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|ensembl:ENSG00000108654(gene)	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/08	rogid:BlaILQg90jqkI5+DdA0k5YTCGOo9606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:rCLJb638b7Lyt1GAwSBO0u7pirM	false	-	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Y490	uniprotkb:P59046	intact:EBI-2462036|uniprotkb:A6NMY0|uniprotkb:Q86YD0|uniprotkb:Q9NZQ2|uniprotkb:Q9UHH8|uniprotkb:Q9UPX3|intact:EBI-28967697|ensembl:ENSP00000316029	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:tln1_human(display_long)|uniprotkb:TLN1(gene name)|psi-mi:TLN1(display_short)|uniprotkb:KIAA1027(gene name synonym)|uniprotkb:TLN(gene name synonym)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499169|imex:IM-27886-63	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000316029|refseq:NP_006280.3|ensembl:ENSG00000137076(gene)|ensembl:ENST00000314888(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0017166"(vinculin binding)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033622"(integrin activation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002558(I/LWEQ)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR015009(Vinculin Binding Site)|interpro:IPR015224(Talin, central)|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR032425|interpro:IPR035963|interpro:IPR035964|interpro:IPR036476|interpro:IPR036723|interpro:IPR037438|mint:Q9Y490|rcsb pdb:1SYQ|rcsb pdb:2MWN|rcsb pdb:4DJ9|rcsb pdb:6R9T|reactome:R-HSA-114608|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381038|reactome:R-HSA-399955|reactome:R-HSA-445355|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/08	rogid:C7FGaR2291KB6hBSloee5L8lYgA9606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:n8jYj/I6oNFcppeYu6ridbtS6lc	false	-	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49069	uniprotkb:P59046	intact:EBI-1748958|uniprotkb:A1L3Y3|ensembl:ENSP00000297156	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:camlg_human(display_long)|uniprotkb:CAMLG(gene name)|psi-mi:CAMLG(display_short)|uniprotkb:CAML(gene name synonym)|uniprotkb:Calcium signal-modulating cyclophilin ligand(gene name synonym)|uniprotkb:GET2(gene name synonym)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499173|imex:IM-27886-43	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001736.1|ensembl:ENSG00000164615(gene)|ensembl:ENST00000297156(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006952"(defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043529"(GET complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|interpro:IPR016719(Calcium signal-modulating cyclophilin ligand)|rcsb pdb:6SO5|reactome:R-HSA-9609523	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/08	rogid:BUKJ1VPumP1iJJnr485rxWzEyK49606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:R6Wl707mDZAkUSixwB/qWNOo+dM	false	-	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O43290	uniprotkb:P59046	intact:EBI-607761|ensembl:ENSP00000310448|uniprotkb:A6NDN1|uniprotkb:Q53GB5	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:snut1_human(display_long)|uniprotkb:U4/U6.U5 tri-snRNP-associated 110 kDa protein(gene name synonym)|uniprotkb:SART1(gene name)|psi-mi:SART1(display_short)|uniprotkb:SNU66 homolog(gene name synonym)|uniprotkb:Squamous cell carcinoma antigen recognized by T-cells 1(gene name synonym)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499194|imex:IM-27886-45	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000175467(gene)|ensembl:ENST00000312397(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000481"(maturation of 5S rRNA)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0045585"(positive regulation of cytotoxic T cell differentiation)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR005011(SART-1 protein)|mint:O43290|rcsb pdb:4PYU|rcsb pdb:5O9Z|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|refseq:NP_005137.1|dip:DIP-33360N	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/08	rogid:egvWHy7UXW+MkGtGEW984yvRU9k9606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:DV6j0FXQgmGvwZqx/z5xZhYju4A	false	-	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q96S59	uniprotkb:P59046	intact:EBI-636085|uniprotkb:A0PJA2|uniprotkb:O94764|uniprotkb:Q6P3T7|uniprotkb:Q7LBR2|uniprotkb:Q7Z7F9|ensembl:ENSP00000011619|uniprotkb:B2R8E1	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:ranb9_human(display_long)|uniprotkb:RanBP7(gene name synonym)|uniprotkb:Ran-binding protein M(gene name synonym)|uniprotkb:BPM90(gene name synonym)|uniprotkb:BPM-L(gene name synonym)|uniprotkb:RANBP9(gene name)|psi-mi:RANBP9(display_short)|uniprotkb:RANBPM(gene name synonym)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499200|imex:IM-27886-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005484.2|ensembl:ENSG00000010017(gene)|ensembl:ENST00000011619(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR006595(CTLH, C-terminal to LisH motif)|interpro:IPR013144(CT11-RanBPM)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024964|interpro:IPR035782|interpro:IPR043136|mint:Q96S59|rcsb pdb:5JI7|rcsb pdb:5JI9|rcsb pdb:5JIU|rcsb pdb:7NSC|reactome:R-HSA-373760|reactome:R-HSA-5673001|go:"GO:1902993"(positive regulation of amyloid precursor protein catabolic process)|reactome:R-HSA-8851805|refseq:XP_006715008.1	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/08	rogid:7jybZidQAgnkobKmGJhZ9xsEeH09606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:ZbxUoGNcZDL9XsD7LawGfd8F4/w	false	-	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Y228	uniprotkb:P59046	intact:EBI-765817|uniprotkb:Q2YDB5|uniprotkb:A6NIU9|uniprotkb:Q4VY06|uniprotkb:Q7Z706|uniprotkb:A1L464|ensembl:ENSP00000355991|ensembl:ENSP00000355992	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:t3jam_human(display_long)|uniprotkb:TRAF3-interacting protein 3(gene name synonym)|uniprotkb:TRAF3IP3(gene name)|psi-mi:TRAF3IP3(display_short)|uniprotkb:T3JAM(gene name synonym)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499206|imex:IM-27886-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079504.2|refseq:NP_001274683.1|refseq:NP_001307072.1|refseq:NP_001307073.1|ensembl:ENSG00000009790(gene)|ensembl:ENST00000367024(transcript)|ensembl:ENST00000367025(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|mint:Q9Y228	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/08	rogid:KDgxJv66FX+o56QzfysW3BS/tKc9606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:NaezJgYF1viJhLmMikwuX/tVPVo	false	-	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q15650	uniprotkb:P59046	intact:EBI-2800143|uniprotkb:Q96ED7|uniprotkb:Q9UKH0|uniprotkb:B2RAS0|ensembl:ENSP00000261884	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:trip4_human(display_long)|uniprotkb:Thyroid receptor-interacting protein 4(gene name synonym)|uniprotkb:TRIP4(gene name)|psi-mi:TRIP4(display_short)|uniprotkb:RQT4(gene name synonym)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499212|imex:IM-27886-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057297.2|refseq:NP_001308853.1|ensembl:ENSG00000103671(gene)|ensembl:ENST00000261884(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045661"(regulation of myoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0099053"(activating signal cointegrator 1 complex)|go:"GO:1901998"(toxin transport)|interpro:IPR007374(Protein of unknown function DUF437)|interpro:IPR009349(Zinc finger, C2HC5-type)|interpro:IPR015947(PUA-like)|interpro:IPR039128|rcsb pdb:2E5O|go:"GO:0005815"(microtubule organizing center)	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/08	rogid:fecS9E0obnl+xsx/r9OrmToZEbs9606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:eQ0cFTQhDh0u8ZobqT/rpKI59ZI	false	-	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P60866	uniprotkb:P59046	intact:EBI-353105|uniprotkb:P17075|uniprotkb:Q5M8S9|uniprotkb:B2R4F4|uniprotkb:B4DW28|ensembl:ENSP00000009589|ensembl:ENSP00000427788|ensembl:ENSP00000503327|ensembl:ENSP00000504123|ensembl:ENSP00000504154|ensembl:ENSP00000504670	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:rs20_human(display_long)|uniprotkb:RPS20(gene name)|psi-mi:RPS20(display_short)|uniprotkb:Small ribosomal subunit protein uS10(gene name synonym)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499218|imex:IM-27886-83	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001014.1|refseq:NP_001139699.1|dip:DIP-31245N|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|ensembl:ENSG00000008988(gene)|ensembl:ENST00000009589(transcript)|ensembl:ENST00000521262(transcript)|ensembl:ENST00000676461(transcript)|ensembl:ENST00000676918(transcript)|ensembl:ENST00000678039(transcript)|ensembl:ENST00000678683(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0045202"(synapse)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|interpro:IPR001848(Ribosomal protein S10)|interpro:IPR005729(Ribosomal protein S10, eukaryotic/archaeal)|interpro:IPR018268|interpro:IPR027486|interpro:IPR036838|mint:P60866|rcsb pdb:4UG0|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/08	rogid:6xNxX+eP59AOm0KraCysRHUqMFw9606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:JD7hbaJN1zp47wYJ61qUVLYYO1s	false	-	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P31146	uniprotkb:P59046	intact:EBI-1046676|ensembl:ENSP00000219150|ensembl:ENSP00000455552|uniprotkb:Q2YD73|uniprotkb:B2RBL1	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:cor1a_human(display_long)|uniprotkb:Coronin-like protein p57(gene name synonym)|uniprotkb:Coronin-like protein A(gene name synonym)|uniprotkb:Tryptophan aspartate-containing coat protein(gene name synonym)|uniprotkb:CORO1A(gene name)|psi-mi:CORO1A(display_short)|uniprotkb:CORO1(gene name synonym)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499224|imex:IM-27886-65	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001180262.1|refseq:NP_009005.1|ensembl:ENSG00000102879(gene)|ensembl:ENST00000219150(transcript)|ensembl:ENST00000570045(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001845"(phagolysosome assembly)|go:"GO:0001891"(phagocytic cup)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006909"(phagocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031339"(negative regulation of vesicle fusion)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0032796"(uropod organization)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043320"(natural killer cell degranulation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051015"(actin filament binding)|go:"GO:0051126"(negative regulation of actin nucleation)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061502"(early endosome to recycling endosome transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0045087"(innate immune response)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR001680(WD40 repeat)|interpro:IPR015048(Region of unknown function DUF1899)|interpro:IPR015049(Region of unknown function DUF1900)|interpro:IPR015505(Coronin)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR029508|interpro:IPR036322|mint:P31146|reactome:R-HSA-9636383|interpro:IPR019775|refseq:XP_011544016.1	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/08	rogid:p2NmQ7YE3FUzyW0Op4rLPLFaVVU9606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:lzzkNTAgBmXnCNNaVcmK0c0p+Gw	false	-	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P15104	uniprotkb:P59046	intact:EBI-746653|uniprotkb:Q499Y9|uniprotkb:Q5T9Z1|uniprotkb:Q7Z3W4|uniprotkb:Q8IZ17|ensembl:ENSP00000307900|ensembl:ENSP00000344958|ensembl:ENSP00000356537|ensembl:ENSP00000398320	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:glna_human(display_long)|uniprotkb:Glutamate--ammonia ligase(gene name synonym)|uniprotkb:GLUL(gene name)|psi-mi:GLUL(display_short)|uniprotkb:GLNS(gene name synonym)|uniprotkb:Palmitoyltransferase GLUL(gene name synonym)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499230|imex:IM-27886-67	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001028216.1|refseq:NP_001028228.1|refseq:NP_002056.2|rcsb pdb:2QC8|reactome:R-HSA-210455|reactome:R-HSA-8964539|rcsb pdb:2OJW|ensembl:ENSG00000135821(gene)|ensembl:ENST00000311223(transcript)|ensembl:ENST00000331872(transcript)|ensembl:ENST00000339526(transcript)|ensembl:ENST00000417584(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0004356"(glutamate-ammonia ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006542"(glutamine biosynthetic process)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009749"(response to glucose)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0016595"(glutamate binding)|go:"GO:0018345"(protein palmitoylation)|go:"GO:0019676"(ammonia assimilation cycle)|go:"GO:0019706"(protein-cysteine S-palmitoyltransferase activity)|go:"GO:0030145"(manganese ion binding)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043209"(myelin sheath)|go:"GO:0043679"(axon terminus)|go:"GO:0045503"(dynein light chain binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097386"(glial cell projection)|go:"GO:1903670"(regulation of sprouting angiogenesis)|go:"GO:1904749"(regulation of protein localization to nucleolus)|interpro:IPR008146(Glutamine synthetase, catalytic region)|interpro:IPR008147(Glutamine synthetase, beta-Grasp)|interpro:IPR014746(Glutamine synthetase/guanido kinase, catalytic region)|interpro:IPR027302|interpro:IPR027303|interpro:IPR036651|mint:P15104|go:"GO:0006538"(glutamate catabolic process)|refseq:XP_006711341.1|dip:DIP-308N	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/08	rogid:UOOgfw1g+kmpsEx64pUbW9GfmYw9606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:T0RSC3w40PgUZd1wAZov6jq2X6Y	false	-	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P60709	uniprotkb:P59046	intact:EBI-353944|uniprotkb:P02570|uniprotkb:P70514|uniprotkb:P99021|uniprotkb:Q11211|uniprotkb:Q64316|uniprotkb:Q75MN2|uniprotkb:Q96B34|uniprotkb:Q96HG5|ensembl:ENSP00000494269|ensembl:ENSP00000494750|ensembl:ENSP00000495995|ensembl:ENSP00000501862|ensembl:ENSP00000502821	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:actb_human(display_long)|uniprotkb:ACTB(gene name)|psi-mi:ACTB(display_short)|uniprotkb:Beta-actin(gene name synonym)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499236|imex:IM-27886-47	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001092.1|ensembl:ENSG00000075624(gene)|ensembl:ENST00000493945(transcript)|ensembl:ENST00000642480(transcript)|ensembl:ENST00000646664(transcript)|ensembl:ENST00000674681(transcript)|ensembl:ENST00000675515(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000785"(chromatin)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007409"(axonogenesis)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030424"(axon)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030957"(Tat protein binding)|go:"GO:0031982"(vesicle)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043044"|go:"GO:0043296"(apical junction complex)|go:"GO:0044305"(calyx of Held)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0048156"(tau protein binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048870"(cell motility)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051623"(positive regulation of norepinephrine uptake)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070160"(tight junction)|go:"GO:0070527"(platelet aggregation)|reactome:R-HSA-4420097|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0072562"(blood microparticle)|go:"GO:0072749"(cellular response to cytochalasin B)|go:"GO:0097433"(dense body)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150111"(regulation of transepithelial transport)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:P60709|rcsb pdb:3BYH|rcsb pdb:3D2U|rcsb pdb:3J82|rcsb pdb:3LUE|rcsb pdb:6ANU|rcsb pdb:6ICT|rcsb pdb:6ICV|rcsb pdb:6LTJ|rcsb pdb:6MBJ|rcsb pdb:6MBK|rcsb pdb:6MBL|rcsb pdb:6NBW|rcsb pdb:6OX0|rcsb pdb:6OX1|rcsb pdb:6OX2|rcsb pdb:6OX3|rcsb pdb:6OX4|rcsb pdb:6OX5|rcsb pdb:6V62|rcsb pdb:6V63|rcsb pdb:6WK1|rcsb pdb:6WK2|rcsb pdb:7AS4|reactome:R-HSA-1445148|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2029482|reactome:R-HSA-3214847|reactome:R-HSA-389957|reactome:R-HSA-390450|reactome:R-HSA-3928662|reactome:R-HSA-3928665|reactome:R-HSA-418990|reactome:R-HSA-437239|reactome:R-HSA-446353|reactome:R-HSA-5250924|reactome:R-HSA-5626467|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5674135|reactome:R-HSA-5689603|reactome:R-HSA-5696394|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8856828|reactome:R-HSA-9035034|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9662360|reactome:R-HSA-9662361|reactome:R-HSA-9664422|reactome:R-HSA-983231|reactome:R-HSA-445095|dip:DIP-29686N	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/06	rogid:Hoge1B8Pn56kvbNTpkSLsQuHwRc9606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:/VI2HIGJawgjWEz5UvXGRkRsxyQ	false	-	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BTA9	uniprotkb:P59046	intact:EBI-749118|intact:EBI-947208|uniprotkb:C9JBT9|uniprotkb:Q5JU75|uniprotkb:Q5JU77|uniprotkb:Q53EN9|uniprotkb:Q5VXK0|uniprotkb:Q5VXK2|uniprotkb:Q8TCK1|uniprotkb:Q96DP3|uniprotkb:Q96FW6|uniprotkb:Q96JI3|uniprotkb:A8K2A9|intact:EBI-1105304|uniprotkb:D3DRW5|uniprotkb:D3DRW6|uniprotkb:D3DRW7|ensembl:ENSP00000346986	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:wac_human(display_long)|uniprotkb:WAC(gene name)|psi-mi:WAC(display_short)|uniprotkb:KIAA1844(gene name synonym)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499242|imex:IM-27886-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517793.1|refseq:NP_057712.2|refseq:NP_567823.1|refseq:NP_567822.1|ensembl:ENSG00000095787(gene)|ensembl:ENST00000354911(transcript)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071894"(histone H2B conserved C-terminal lysine ubiquitination)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR036020|interpro:IPR038867|reactome:R-HSA-8866654|go:"GO:0016607"(nuclear speck)	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/08	rogid:TuCxRb98Y5EGRbK1RRNMi/VnXV89606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:UyHfUzrd56t70TipsV0GnkkPCc4	false	-	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NRR4	uniprotkb:P59046	intact:EBI-528367|uniprotkb:Q7Z5V2|uniprotkb:Q86YH0|uniprotkb:Q9NW73|uniprotkb:Q9Y2V9|uniprotkb:Q9Y4Y0|intact:EBI-10973107|uniprotkb:E7EMP9|ensembl:ENSP00000339845|ensembl:ENSP00000425979	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:rnc_human(display_long)|uniprotkb:Ribonuclease III(gene name synonym)|uniprotkb:DROSHA(gene name)|psi-mi:DROSHA(display_short)|uniprotkb:p241(gene name synonym)|uniprotkb:RNASEN(gene name synonym)|uniprotkb:RN3(gene name synonym)|uniprotkb:RNASE3L(gene name synonym)|uniprotkb:Protein Drosha(gene name synonym)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499248|imex:IM-27886-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001093882.1|refseq:NP_037367.3|refseq:XP_005248348.1|refseq:XP_005248351.1|ensembl:ENSG00000113360(gene)|ensembl:ENST00000344624(transcript)|ensembl:ENST00000511367(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006396"(RNA processing)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045589"(regulation of regulatory T cell differentiation)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070877"(microprocessor complex)|go:"GO:0070878"(primary miRNA binding)|go:"GO:2000628"(regulation of miRNA metabolic process)|interpro:IPR000999(Ribonuclease III)|interpro:IPR011907(Ribonuclease III, bacterial)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR036389|interpro:IPR044442|rcsb pdb:2KHX|rcsb pdb:2NA2|rcsb pdb:5B16|rcsb pdb:6LXD|rcsb pdb:6LXE|rcsb pdb:6V5B|rcsb pdb:6V5C|reactome:R-HSA-203927|dip:DIP-33300N	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/08	rogid:vHfmSHxD1M/Sh4dbo2S7FBaE+eQ9606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:u5PZvIFuwjB5g2Ga1lGo695Pf8w	false	-	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q96EY1	uniprotkb:P59046	intact:EBI-356767|uniprotkb:O75472|uniprotkb:Q8WUJ6|uniprotkb:Q8WXJ3|uniprotkb:Q96D76|uniprotkb:Q96IV1|uniprotkb:Q9NYH8|uniprotkb:B2RAJ5|uniprotkb:B4DI33|uniprotkb:E7ES32|ensembl:ENSP00000262375|ensembl:ENSP00000477570	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:dnja3_human(display_long)|uniprotkb:DNAJA3(gene name)|psi-mi:DNAJA3(display_short)|uniprotkb:TID1(gene name synonym)|uniprotkb:HCA57(gene name synonym)|uniprotkb:Tumorous imaginal discs protein Tid56 homolog(gene name synonym)|uniprotkb:DnaJ protein Tid-1(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated antigen 57(gene name synonym)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499254|imex:IM-27886-69	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001273445.1|refseq:NP_001128582.1|refseq:NP_005138.3|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060336"(negative regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0106137"(IkappaB kinase complex binding)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR018253|interpro:IPR036410|interpro:IPR036869|mint:Q96EY1|rcsb pdb:2CTT|rcsb pdb:2DN9|rcsb pdb:6IWS|ensembl:ENSG00000103423(gene)|ensembl:ENSG00000276726(gene)|ensembl:ENST00000262375(transcript)|ensembl:ENST00000612103(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005133"(interferon-gamma receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006264"(mitochondrial DNA replication)|go:"GO:0006457"(protein folding)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007569"(cell aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051059"(NF-kappaB binding)|dip:DIP-33870N	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/08	rogid:WnRYdQ9E3yGbSlq1SSGTX9k+3uA9606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:RBYuYpOuK+qvoKnP9ZwolzxDGno	false	-	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P23469	uniprotkb:P59046	intact:EBI-2258070|uniprotkb:Q13345|uniprotkb:Q96KQ6|uniprotkb:Q5VWH3|uniprotkb:Q5VWH4|ensembl:ENSP00000254667	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:ptpre_human(display_long)|uniprotkb:PTPRE(gene name)|psi-mi:PTPRE(display_short)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499260|imex:IM-27886-49	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001303605.1|refseq:NP_001303606.1|refseq:XP_016871957.1|refseq:NP_006495.1|refseq:XP_005252748.1|refseq:NP_001310283.1|refseq:NP_569119.1|ensembl:ENSG00000132334(gene)|ensembl:ENST00000254667(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR016336(Receptor tyrosine-protein phosphatase, alpha/epsilon-type)|interpro:IPR029021|rcsb pdb:2JJD|rcsb pdb:6D3F|rcsb pdb:6D4D|rcsb pdb:6D4F	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/08	rogid:dNMLfHqBmbW25nCn5i+ZPPuNrOQ9606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:b/qpbfsj0AVkXRf+SS/rTvaXh0I	false	-	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9UMX0	uniprotkb:P59046	intact:EBI-741480|uniprotkb:Q8IXS9|uniprotkb:Q8N2Q3|uniprotkb:Q9H0T8|uniprotkb:Q9H3R4|uniprotkb:Q9HAZ5|intact:EBI-28967608|ensembl:ENSP00000365576|uniprotkb:Q5T6J5|uniprotkb:Q5T6J9|uniprotkb:A0A024R284	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:ubql1_human(display_long)|uniprotkb:Protein linking IAP with cytoskeleton 1(gene name synonym)|uniprotkb:UBQLN1(gene name)|psi-mi:UBQLN1(display_short)|uniprotkb:DA41(gene name synonym)|uniprotkb:PLIC1(gene name synonym)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499266|imex:IM-27886-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000257468|ensembl:ENSP00000257468|ensembl:ENSP00000365576|ensembl:ENSG00000135018(gene)|ensembl:ENST00000376395(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000502"(proteasome complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0019900"(kinase binding)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035973"(aggrephagy)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097352"(autophagosome maturation)|go:"GO:1901340"(negative regulation of store-operated calcium channel activity)|go:"GO:1902175"(regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR028430|interpro:IPR029071|mint:Q9UMX0|rcsb pdb:2JY5|rcsb pdb:2JY6|rcsb pdb:2KLC|reactome:R-HSA-8856825|refseq:NP_038466.2|refseq:NP_444295.1|dip:DIP-41629N	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/08	rogid:nCFfZbGCTvRYaXhQ4R99XblslvM9606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:PC54/xfD0Gu/8c9Nvq/2usf4XEk	false	-	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13489	uniprotkb:P59046	intact:EBI-517709|uniprotkb:Q16628|uniprotkb:Q9HC27|uniprotkb:Q9UP46|ensembl:ENSP00000263464|ensembl:ENSP00000432907|ensembl:ENSP00000481903|ensembl:ENSP00000501119	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:birc3_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 1(gene name synonym)|uniprotkb:TNFR2-TRAF-signaling complex protein 1(gene name synonym)|uniprotkb:IAP homolog C(gene name synonym)|uniprotkb:Apoptosis inhibitor 2(gene name synonym)|uniprotkb:RING finger protein 49(gene name synonym)|uniprotkb:BIRC3(gene name)|psi-mi:BIRC3(display_short)|uniprotkb:API2(gene name synonym)|uniprotkb:MIHC(gene name synonym)|uniprotkb:RNF49(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC3(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 2(gene name synonym)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499272|imex:IM-27886-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000023445(gene)|ensembl:ENST00000263464(transcript)|ensembl:ENST00000526421(transcript)|ensembl:ENST00000532808(transcript)|ensembl:ENST00000615299(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0039535"(regulation of RIG-I signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|refseq:NP_001156.1|refseq:NP_892007.1|refseq:XP_016873132.1|dip:DIP-33720N|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:2000116"(regulation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|rcsb pdb:2UVL|rcsb pdb:3EB5|rcsb pdb:3EB6|rcsb pdb:3M0A|rcsb pdb:3M0D|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-937041	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/08	rogid:TBTCMhQ/t2ZIBvxbWIiiv4oo9bc9606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:WfdjzG+dYuUgt/S3O8uZlJgI4wA	false	-	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9HCJ0	uniprotkb:P59046	intact:EBI-6507625|uniprotkb:Q86UE5|uniprotkb:Q8N3D8|uniprotkb:Q96MU9|uniprotkb:G3XAB8|ensembl:ENSP00000301624|ensembl:ENSP00000468647	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:tnr6c_human(display_long)|uniprotkb:TNRC6C(gene name)|psi-mi:TNRC6C(display_short)|uniprotkb:KIAA1582(gene name synonym)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499278|imex:IM-27886-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001136112.1|refseq:NP_061869.2|ensembl:ENSG00000078687(gene)|ensembl:ENST00000301624(transcript)|ensembl:ENST00000588061(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|interpro:IPR009060(UBA-like)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR019486|interpro:IPR026805|interpro:IPR032226|interpro:IPR033499|interpro:IPR034927|interpro:IPR035979|interpro:IPR041917|rcsb pdb:2DKL|rcsb pdb:2X04|rcsb pdb:3KTP|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-4086398|reactome:R-HSA-426496|reactome:R-HSA-5628897|reactome:R-HSA-5687128|reactome:R-HSA-8853884|reactome:R-HSA-8934593|reactome:R-HSA-8936459|reactome:R-HSA-8943723|reactome:R-HSA-8948700|reactome:R-HSA-8986944|reactome:R-HSA-9018519|reactome:R-HSA-9022692|reactome:R-HSA-9029569|dip:DIP-48569N	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/08	rogid:OZUDlEQ+h+8y51DpPQfEGB7tfx89606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:FpX8VvBBU3zroT9WRo4Dyu8D9eg	false	-	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P05186	uniprotkb:P59046	intact:EBI-1054354|uniprotkb:A1A4E7|uniprotkb:O75090|uniprotkb:Q2TAI7|uniprotkb:Q59EJ7|uniprotkb:Q5BKZ5|uniprotkb:Q5VTG5|uniprotkb:Q6NZI8|uniprotkb:Q8WU32|uniprotkb:Q9UBK0|uniprotkb:B7Z387|uniprotkb:B2RMP8|uniprotkb:B7Z4Y6|ensembl:ENSP00000363965|ensembl:ENSP00000363973	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:ppbt_human(display_long)|uniprotkb:Alkaline phosphatase liver/bone/kidney isozyme(gene name synonym)|uniprotkb:ALPL(gene name)|psi-mi:ALPL(display_short)|uniprotkb:Phosphoamidase(gene name synonym)|uniprotkb:Phosphocreatine phosphatase(gene name synonym)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499284|imex:IM-27886-85	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000469.3|refseq:NP_001120973.2|refseq:NP_001170991.1|refseq:XP_005245875.1|refseq:XP_006710609.1|ensembl:ENSG00000162551(gene)|ensembl:ENST00000374832(transcript)|ensembl:ENST00000374840(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0004035"(alkaline phosphatase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016462"(pyrophosphatase activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033280"(response to vitamin D)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071529"(cementum mineralization)|interpro:IPR001952(Alkaline phosphatase)|interpro:IPR017850(Alkaline-phosphatase-like, core domain)|interpro:IPR018299|reactome:R-HSA-163125	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/08	rogid:iO0/TZ5yjqLOEZWp673XGt02mnI9606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:ZMTRWmw7JoyUa46GrIuHGdHz+2w	false	-	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O94906	uniprotkb:P59046	intact:EBI-536755|uniprotkb:O95109|uniprotkb:Q5VXS5|uniprotkb:Q9H3Z1|uniprotkb:Q9H4T9|uniprotkb:Q9H4U8|uniprotkb:Q9NTE6|ensembl:ENSP00000266079|uniprotkb:B2RAR5|uniprotkb:B3KMC6	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:prp6_human(display_long)|uniprotkb:U5 snRNP-associated 102 kDa protein(gene name synonym)|uniprotkb:PRP6 homolog(gene name synonym)|uniprotkb:PRPF6(gene name)|psi-mi:PRPF6(display_short)|uniprotkb:C20orf14(gene name synonym)|uniprotkb:Androgen receptor N-terminal domain-transactivating protein 1(gene name synonym)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499290|imex:IM-27886-33	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101161(gene)|ensembl:ENST00000266079(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0006403"(RNA localization)|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR010491(PRP1 splicing factor, N-terminal)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR027108|mint:O94906|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:NP_036601.2|dip:DIP-29006N	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/08	rogid:M5ovIXl+1ob6VSKbXZUGU73J7Jk9606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:mTb5FozrMdJAEZogwqaiHE+nvI0	false	-	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q14CS0	uniprotkb:P59046	intact:EBI-1993619|uniprotkb:B3KWZ3|ensembl:ENSP00000382507	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:ubx2b_human(display_long)|uniprotkb:UBXN2B(gene name)|psi-mi:UBXN2B(display_short)|uniprotkb:NSFL1 cofactor p37(gene name synonym)|uniprotkb:p97 cofactor p37(gene name synonym)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499296|imex:IM-27886-87	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001071087.1|refseq:NP_001317464.1|ensembl:ENSG00000215114(gene)|ensembl:ENST00000399598(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007030"(Golgi organization)|go:"GO:0031468"(nuclear membrane reassembly)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0046604"(positive regulation of mitotic centrosome separation)|go:"GO:0061025"(membrane fusion)|go:"GO:1904780"(negative regulation of protein localization to centrosome)|interpro:IPR001012(UBX)|interpro:IPR012989(SEP)|interpro:IPR029071|interpro:IPR036241	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/08	rogid:tCd/qJLW1wYuC3WTakXevcMRtPU9606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:6giwBUGATW4YRdNZP/nwOkrm83g	false	-	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P46379	uniprotkb:P59046	intact:EBI-347552|uniprotkb:A2ADJ7|uniprotkb:A3KQ42|uniprotkb:A3KQ44|uniprotkb:A6NGY6|uniprotkb:A6PWF7|uniprotkb:O95874|uniprotkb:Q5HYL9|uniprotkb:Q5SQ35|uniprotkb:Q5SQ36|uniprotkb:Q5SQ37|uniprotkb:Q5SQ41|uniprotkb:Q5SRP8|uniprotkb:Q5SRP9|uniprotkb:Q5STC1|uniprotkb:Q5STX1|uniprotkb:Q5STX3|uniprotkb:Q96SA6|uniprotkb:Q9BCN4|uniprotkb:B0UX84|uniprotkb:B4DZ12|uniprotkb:B4E3V4|uniprotkb:E7EMZ4|uniprotkb:F8VXY4|ensembl:ENSP00000354368|ensembl:ENSP00000390966|ensembl:ENSP00000397894	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:bag6_human(display_long)|uniprotkb:BAT3(gene name synonym)|uniprotkb:G3(gene name synonym)|uniprotkb:HLA-B-associated transcript 3(gene name synonym)|uniprotkb:Protein G3(gene name synonym)|uniprotkb:BCL2-associated athanogene 6(gene name synonym)|uniprotkb:BAG6(gene name)|psi-mi:BAG6(display_short)|uniprotkb:BAG family molecular chaperone regulator 6(gene name synonym)|uniprotkb:Protein Scythe(gene name synonym)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499302|imex:IM-27886-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-31191N|refseq:NP_001092004.1|refseq:NP_001186627.1|refseq:NP_004630.3|refseq:NP_542433.1|refseq:NP_542434.1|refseq:NP_001186626.1|refseq:XP_016866776.1|ensembl:ENSG00000096155(gene)|ensembl:ENSG00000229524(gene)|ensembl:ENSG00000233348(gene)|ensembl:ENST00000361076(transcript)|ensembl:ENST00000449450(transcript)|ensembl:ENST00000451932(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002429"(immune response-activating cell surface receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070628"(proteasome binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|go:"GO:1904379"(protein localization to cytosolic proteasome complex involved in ERAD pathway)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR021925|interpro:IPR029071|mint:P46379|rcsb pdb:1WX9|rcsb pdb:2N9P|rcsb pdb:4DWF|rcsb pdb:4EEW|rcsb pdb:4WWR|rcsb pdb:6AU8|reactome:R-HSA-9609523|rcsb pdb:4X86	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/08	rogid:ghHlLBbS3yeP2mN6AOoHs+CECKU9606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:1KlKOJL7OM6tQgiChAa76VNvEBk	false	-	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8WVN6	uniprotkb:P59046	intact:EBI-2855289|uniprotkb:O00466|uniprotkb:B2R7H0|ensembl:ENSP00000269389	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:sctm1_human(display_long)|uniprotkb:SECTM1(gene name)|psi-mi:SECTM1(display_short)|uniprotkb:K12(gene name synonym)|uniprotkb:Protein K-12(gene name synonym)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499308|imex:IM-27886-51	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011521890.1|refseq:NP_002995.1|refseq:XP_005256449.1|ensembl:ENSG00000141574(gene)|ensembl:ENST00000269389(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007498"(mesoderm development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0070062"(extracellular exosome)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033231	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/08	rogid:DJWAFI1b9UmmY+9fyomqgBeRu/w9606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:Y4nJnt+NzAtcNYcqy27kZxHtBq8	false	-	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q96F10	uniprotkb:P59046	intact:EBI-748746|ensembl:ENSP00000269298	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:sat2_human(display_long)|uniprotkb:"Spermidine/spermine N(1)-acetyltransferase 2"(gene name synonym)|uniprotkb:SAT2(gene name)|psi-mi:SAT2(display_short)|uniprotkb:SSAT2(gene name synonym)|uniprotkb:Diamine acetyltransferase 2(gene name synonym)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499314|imex:IM-27886-53	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_597998.1|refseq:NP_001307775.1|refseq:NP_001307776.1|ensembl:ENSG00000141504(gene)|ensembl:ENST00000269298(transcript)|go:"GO:0004145"(diamine N-acetyltransferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0008080"(N-acetyltransferase activity)|go:"GO:0019809"(spermidine binding)|go:"GO:0032918"(spermidine acetylation)|go:"GO:0032920"(putrescine acetylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0046204"(nor-spermidine metabolic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000182(GCN5-related N-acetyltransferase)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR032959|mint:Q96F10|rcsb pdb:2BEI|rcsb pdb:2Q4V|go:"GO:0032919"(spermine acetylation)	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/08	rogid:za90gPs85bZdWO7RYTGA9V7nazY9606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:c09NICTbTmYx2eNxo0ply5fDpzc	false	-	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BUY5	uniprotkb:P59046	intact:EBI-743265|ensembl:ENSP00000253115|ensembl:ENSP00000439017|uniprotkb:B3KTL2	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:zn426_human(display_long)|uniprotkb:ZNF426(gene name)|psi-mi:ZNF426(display_short)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499320|imex:IM-27886-55	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077011.1|ensembl:ENSG00000130818(gene)|ensembl:ENST00000253115(transcript)|ensembl:ENST00000535489(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|reactome:R-HSA-212436|refseq:NP_001304984.1|refseq:NP_001304985.1	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/08	rogid:QPI15/Fod+FtlArvKKNMPGSu3zQ9606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:cDy7vA7oaek/59wUKr0XtFDxcpg	false	-	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P01889	uniprotkb:P59046	intact:EBI-1046513|ensembl:ENSP00000399168|uniprotkb:O62901|uniprotkb:O95730|uniprotkb:O98140|uniprotkb:P79542|uniprotkb:Q95369|uniprotkb:Q95J00|uniprotkb:Q9GJ20|uniprotkb:Q9MY78|uniprotkb:Q9MYF4|uniprotkb:Q9TQH6|uniprotkb:Q9TQM2|uniprotkb:Q9UQT0|intact:EBI-1049793|intact:EBI-6163549|intact:EBI-6163552|intact:EBI-6163582|intact:EBI-6163570|intact:EBI-6163579|intact:EBI-6163555|intact:EBI-9978548|intact:EBI-1047909|intact:EBI-8770324|uniprotkb:A0A2I6Q7B5|uniprotkb:B0V0B8|uniprotkb:G3GN01|uniprotkb:O02862|uniprotkb:O02956|uniprotkb:O02957|uniprotkb:O02960|uniprotkb:O19555|uniprotkb:O19556|uniprotkb:O19595|uniprotkb:O19615|uniprotkb:O19624|uniprotkb:O78163|uniprotkb:O78172|intact:EBI-1054175|uniprotkb:O19625|uniprotkb:O19627|uniprotkb:O19641|uniprotkb:O19651|uniprotkb:O19675|uniprotkb:O19692|uniprotkb:O19758|uniprotkb:O19779|uniprotkb:O19783|uniprotkb:O46702|uniprotkb:O62897|uniprotkb:O62915|uniprotkb:O62917|uniprotkb:O62919|uniprotkb:O77933|uniprotkb:O77959|uniprotkb:O78053|uniprotkb:O78138|uniprotkb:O78160|uniprotkb:O78173|uniprotkb:O78180|uniprotkb:O78217|uniprotkb:P01890|uniprotkb:P03989|uniprotkb:P10317|uniprotkb:P10318|uniprotkb:P10319|uniprotkb:P10320|uniprotkb:P18463|uniprotkb:P18464|uniprotkb:P18465|uniprotkb:P19373|uniprotkb:P30460|uniprotkb:P30461|uniprotkb:P30462|uniprotkb:P30463|uniprotkb:P30464|uniprotkb:P30465|uniprotkb:P30466|uniprotkb:P30467|uniprotkb:P30468|uniprotkb:P30469|uniprotkb:P30470|uniprotkb:P30471|uniprotkb:P30472|uniprotkb:P30473|uniprotkb:P30474|uniprotkb:P30475|uniprotkb:P30476|uniprotkb:P30477|uniprotkb:P30478|uniprotkb:P30479|uniprotkb:P30480|uniprotkb:P30481|uniprotkb:Q29693|uniprotkb:Q29695|uniprotkb:Q29697|uniprotkb:Q29718|uniprotkb:Q29742|uniprotkb:Q29749|uniprotkb:Q29762|uniprotkb:Q29764|uniprotkb:Q29829|uniprotkb:Q29836|uniprotkb:Q29842|uniprotkb:Q29845|uniprotkb:Q29846|uniprotkb:Q29847|uniprotkb:Q29848|uniprotkb:Q29850|uniprotkb:Q29851|uniprotkb:Q29852|uniprotkb:P30482|uniprotkb:P30483|uniprotkb:P30484|uniprotkb:P30485|uniprotkb:P30486|uniprotkb:P30487|uniprotkb:P30488|uniprotkb:P30489|uniprotkb:P30490|uniprotkb:P30491|uniprotkb:P30492|uniprotkb:P30493|uniprotkb:P30494|uniprotkb:P30495|uniprotkb:P30496|uniprotkb:P30497|uniprotkb:P30498|uniprotkb:P30513|uniprotkb:P30685|uniprotkb:P79489|uniprotkb:P79490|uniprotkb:P79496|uniprotkb:P79504|uniprotkb:P79523|uniprotkb:P79524|uniprotkb:P79555|uniprotkb:Q04826|uniprotkb:Q08136|uniprotkb:Q29633|uniprotkb:Q29636|uniprotkb:Q29638|uniprotkb:Q29661|uniprotkb:Q29665|uniprotkb:Q29678|uniprotkb:Q29679|uniprotkb:Q29681|uniprotkb:Q29935|uniprotkb:Q29936|uniprotkb:Q29940|uniprotkb:Q29953|uniprotkb:Q29961|uniprotkb:Q29982|intact:EBI-4289931|intact:EBI-7382650|intact:MINT-144207|intact:EBI-7245379|intact:MINT-1195012|intact:EBI-1059117|intact:EBI-4289845|uniprotkb:Q29854|uniprotkb:Q29855|uniprotkb:Q29857|uniprotkb:Q29858|uniprotkb:Q29861|uniprotkb:Q29924|uniprotkb:Q29925|uniprotkb:Q29933|uniprotkb:Q8MHN4|uniprotkb:Q30173|uniprotkb:Q30198|uniprotkb:Q31603|uniprotkb:Q31610|uniprotkb:Q31612|uniprotkb:Q31613|uniprotkb:Q546L8|uniprotkb:Q546M4|uniprotkb:Q5JP37|uniprotkb:Q5QT24|uniprotkb:Q5RIP1|uniprotkb:Q5SRJ2|uniprotkb:Q5TK76|uniprotkb:Q5TK77|uniprotkb:Q860I4|uniprotkb:Q861B5|uniprotkb:Q8HWF0|uniprotkb:Q8MGQ3|uniprotkb:Q8SNC5|uniprotkb:Q95343|uniprotkb:Q95344|uniprotkb:Q95365|uniprotkb:Q95392|uniprotkb:Q95HA3|uniprotkb:Q95HA8|uniprotkb:Q95HM9|uniprotkb:Q95IA6|uniprotkb:Q95IB8|uniprotkb:Q95IH5|uniprotkb:Q96IT9|uniprotkb:Q9BCM6|uniprotkb:Q9BCM7|uniprotkb:Q9BCM8|uniprotkb:Q9BD06|uniprotkb:Q9BD38|uniprotkb:Q9BD43|uniprotkb:Q9GIL3|uniprotkb:Q9GIM3|uniprotkb:Q9GIX1|uniprotkb:Q9GIY5|uniprotkb:Q9GIZ0|uniprotkb:Q9GIZ9|uniprotkb:Q9GJ00|uniprotkb:Q9GJ17|uniprotkb:Q9GJ23|uniprotkb:Q9GJ31|uniprotkb:Q9GJF0|uniprotkb:Q9GJM7|uniprotkb:Q9MX21|uniprotkb:Q9MY37|uniprotkb:Q9MY42|uniprotkb:Q9MY43|uniprotkb:Q9MY61|uniprotkb:Q9MY75|uniprotkb:Q9MY79|uniprotkb:Q9MY84|uniprotkb:Q9MY92|uniprotkb:Q9MY93|uniprotkb:Q9MY94|uniprotkb:Q9MYB8|uniprotkb:Q9MYC3|uniprotkb:Q9MYC7|uniprotkb:Q9MYG1|uniprotkb:Q9TP35|uniprotkb:Q9UQS8|uniprotkb:Q9TP36|uniprotkb:Q9TP37|uniprotkb:Q9TP95|uniprotkb:Q9TPQ7|uniprotkb:Q9TPQ9|uniprotkb:Q9TPR2|uniprotkb:Q9TPR4|uniprotkb:Q9TPS6|uniprotkb:Q9TPT2|uniprotkb:Q9TPT4|uniprotkb:Q9TPT6|uniprotkb:Q9TPV2|uniprotkb:Q9TQG1|uniprotkb:Q9TQH3|uniprotkb:Q9TQH7|uniprotkb:Q9TQH8|uniprotkb:Q9TQH9|uniprotkb:Q9TQN4|uniprotkb:Q9TQN6	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:hlab_human(display_long)|uniprotkb:Human leukocyte antigen B(gene name synonym)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:HLAB(gene name synonym)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499326|imex:IM-27886-89	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:2HJL|rcsb pdb:2NW3|rcsb pdb:2A83|rcsb pdb:2NX5|rcsb pdb:2RFX|rcsb pdb:2YPK|rcsb pdb:2YPL|rcsb pdb:3B3I|rcsb pdb:3B6S|rcsb pdb:3BP4|rcsb pdb:3BP7|rcsb pdb:3BW9|rcsb pdb:3BWA|rcsb pdb:3C9N|rcsb pdb:3CZF|rcsb pdb:3D18|rcsb pdb:3DTX|rcsb pdb:2AK4|rcsb pdb:3DX6|rcsb pdb:3DX7|rcsb pdb:2AXF|rcsb pdb:3DX8|rcsb pdb:3DXA|rcsb pdb:3FFC|rcsb pdb:3HCV|rcsb pdb:2AXG|rcsb pdb:2BSR|rcsb pdb:2BSS|rcsb pdb:2BST|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:3KPL|rcsb pdb:3KPM|rcsb pdb:3KPN|rcsb pdb:3KPO|rcsb pdb:3KPP|rcsb pdb:3KPQ|rcsb pdb:3KPR|rcsb pdb:3KPS|rcsb pdb:3KWW|rcsb pdb:3KXF|rcsb pdb:3L3D|rcsb pdb:2H6P|rcsb pdb:3L3G|rcsb pdb:3L3I|rcsb pdb:3L3J|rcsb pdb:3L3K|rcsb pdb:3LN5|rcsb pdb:3LV3|rcsb pdb:3MV7|rcsb pdb:3LKN|rcsb pdb:3LKO|rcsb pdb:3LKP|rcsb pdb:3MV8|rcsb pdb:3MV9|rcsb pdb:3SJV|rcsb pdb:3SKM|rcsb pdb:3SKO|rcsb pdb:3SPV|rcsb pdb:3UPR|rcsb pdb:3VCL|rcsb pdb:3VFS|rcsb pdb:3VFT|rcsb pdb:3VFU|rcsb pdb:3VFV|rcsb pdb:3VFW|rcsb pdb:3VH8|rcsb pdb:3VRI|rcsb pdb:3LKQ|rcsb pdb:3LKR|rcsb pdb:3LKS|rcsb pdb:3LN4|rcsb pdb:3VRJ|rcsb pdb:3W39|rcsb pdb:3WUW|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:3X13|rcsb pdb:3X14|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|interpro:IPR037055|rcsb pdb:1A1M|rcsb pdb:1A1N|interpro:IPR036179|rcsb pdb:1A1O|rcsb pdb:1A9B|rcsb pdb:1A9E|rcsb pdb:1AGB|rcsb pdb:1AGC|rcsb pdb:1AGD|rcsb pdb:1AGE|rcsb pdb:1AGF|rcsb pdb:1CG9|rcsb pdb:1E27|rcsb pdb:1E28|rcsb pdb:1HSA|rcsb pdb:1JGD|rcsb pdb:1JGE|rcsb pdb:1K5N|rcsb pdb:1M05|rcsb pdb:1M6O|rcsb pdb:1MI5|rcsb pdb:1N2R|rcsb pdb:1OF2|rcsb pdb:1OGT|rcsb pdb:1SYS|rcsb pdb:1SYV|rcsb pdb:1UXS|rcsb pdb:1UXW|rcsb pdb:1W0V|rcsb pdb:1W0W|rcsb pdb:1XH3|rcsb pdb:1XR8|rcsb pdb:1XR9|rcsb pdb:1ZHK|rcsb pdb:1ZHL|rcsb pdb:1ZSD|rcsb pdb:4JQV|rcsb pdb:4JQX|rcsb pdb:4LCY|rcsb pdb:4LNR|rcsb pdb:4MJI|rcsb pdb:4G9F|rcsb pdb:4O2C|rcsb pdb:4O2E|rcsb pdb:4O2F|rcsb pdb:4PR5|rcsb pdb:4PRN|rcsb pdb:4QRP|rcsb pdb:4QRQ|rcsb pdb:4QRR|rcsb pdb:4QRS|rcsb pdb:4QRT|rcsb pdb:4QRU|rcsb pdb:4U1H|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1K|rcsb pdb:4U1L|rcsb pdb:4U1M|rcsb pdb:4U1N|rcsb pdb:4U1S|rcsb pdb:4XXC|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:5DEF|rcsb pdb:5DEG|rcsb pdb:5EO0|rcsb pdb:5EO1|rcsb pdb:5IB1|rcsb pdb:5IB2|rcsb pdb:5IB3|rcsb pdb:5TXS|rcsb pdb:5U98|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5IB4|rcsb pdb:5IB5|rcsb pdb:5IEH|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5IEK|rcsb pdb:5VUF|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5VWH|rcsb pdb:5VWJ|rcsb pdb:5VZ5|rcsb pdb:5WMN|rcsb pdb:5WMO|rcsb pdb:5WMP|rcsb pdb:5IM7|rcsb pdb:5WMQ|rcsb pdb:5WMR|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5INC|rcsb pdb:6AT5|rcsb pdb:6AVF|rcsb pdb:5IND|rcsb pdb:5T6W|rcsb pdb:6AVG|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6BJ8|rcsb pdb:6BXP|rcsb pdb:5T6X|rcsb pdb:6BXQ|rcsb pdb:5T6Y|rcsb pdb:6D29|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T|rcsb pdb:6MT3|rcsb pdb:6MT4|rcsb pdb:6MT5|rcsb pdb:6MT6|ensembl:ENSG00000234745(gene)|ensembl:ENST00000412585(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032655"(regulation of interleukin-12 production)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:6MTM|rcsb pdb:6P23|rcsb pdb:6P27|rcsb pdb:6P2C|rcsb pdb:6P2F|rcsb pdb:6P2S|rcsb pdb:6PYJ|rcsb pdb:6PYL|rcsb pdb:6PYV|rcsb pdb:6PYW|rcsb pdb:6PZ5|rcsb pdb:6UJ7|rcsb pdb:6UJ8|rcsb pdb:6UJ9|rcsb pdb:6VMX|rcsb pdb:7LFZ|rcsb pdb:7LG0|rcsb pdb:7LGD|rcsb pdb:7LGT|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6MTL|refseq:NP_005505.2	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/08	rogid:NlO2PZ/66RypUzj8Euht3hRq8H89606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:1977YysiaUgPzX5+hER0uHmcfqg	false	-	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P35556	uniprotkb:P59046	intact:EBI-6164392|ensembl:ENSP00000424571|ensembl:ENSP00000262464|uniprotkb:B4DU01|uniprotkb:Q59ES6	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:fbn2_human(display_long)|uniprotkb:FBN2(gene name)|psi-mi:FBN2(display_short)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499332|imex:IM-27886-71	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR026823|interpro:IPR036773|interpro:IPR040872|mint:P35556|reactome:R-HSA-1474228|reactome:R-HSA-1566948|reactome:R-HSA-2129379|interpro:IPR018097|ensembl:ENSG00000138829(gene)|ensembl:ENST00000262464(transcript)|ensembl:ENST00000508053(transcript)|go:"GO:0001527"(microfibril)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0030023"(extracellular matrix constituent conferring elasticity)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035583"(sequestering of TGFbeta in extracellular matrix)|go:"GO:0043010"(camera-type eye development)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0048048"(embryonic eye morphogenesis)|go:"GO:0060346"(bone trabecula formation)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011398(Fibrillin)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR017878|refseq:NP_001990.2	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/08	rogid:iqBnjHuy9kU3serIc5tPWGIDzUc9606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:uGe5kzR1dPMxsNGnfLeciL/YABc	false	-	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P78314	uniprotkb:P59046	intact:EBI-727062|uniprotkb:O00500|uniprotkb:O15373|uniprotkb:P78315|uniprotkb:A6NNC2|uniprotkb:B2R5R6|uniprotkb:B4DT04|uniprotkb:D3DVR0|intact:EBI-28985856|ensembl:ENSP00000348685|ensembl:ENSP00000422168|uniprotkb:D6R919	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:3bp2_human(display_long)|uniprotkb:SH3BP2(gene name)|psi-mi:SH3BP2(display_short)|uniprotkb:3BP2(gene name synonym)|uniprotkb:RES4-23(orf name)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499338|imex:IM-27886-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001116153.1|refseq:NP_001139327.1|refseq:NP_001139328.1|refseq:NP_003014.3|ensembl:ENSP00000348685|ensembl:ENST00000435136|ensembl:ENSP00000403231|ensembl:ENSP00000422168|ensembl:ENST00000511747|ensembl:ENSP00000424846|ensembl:ENST00000513020|ensembl:ENSP00000424072|ensembl:ENST00000515737|ensembl:ENSP00000422605|ensembl:ENSG00000087266(gene)|ensembl:ENST00000356331(transcript)|ensembl:ENST00000503393(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0007165"(signal transduction)|go:"GO:0017124"(SH3 domain binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035847|interpro:IPR035848|interpro:IPR036860|mint:P78314|rcsb pdb:2CR4|rcsb pdb:3TWR	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/08	rogid:W+/geQfSvLlQA6UvDPYN4zQCzh89606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:rhBlZB4Nb3sHrRw1W14YPYaRouw	false	-	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O00160	uniprotkb:P59046	intact:EBI-741792|uniprotkb:Q8WWN7|ensembl:ENSP00000481682|ensembl:ENSP00000494550	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:myo1f_human(display_long)|uniprotkb:Myosin-Ie(gene name synonym)|uniprotkb:MYO1F(gene name)|psi-mi:MYO1F(display_short)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499344|imex:IM-27886-91	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036467.2|ensembl:ENSG00000142347(gene)|ensembl:ENST00000613525(transcript)|ensembl:ENST00000644032(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007015"(actin filament organization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016461"(unconventional myosin complex)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0031982"(vesicle)|go:"GO:0051015"(actin filament binding)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001452(Src homology-3)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR010926(Myosin tail 2)|interpro:IPR027417|interpro:IPR035507|interpro:IPR036028|interpro:IPR036072|interpro:IPR036961	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/08	rogid:k11A+oPM3i3NjaFa80A73soCqCE9606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:flYaNgN9Y1X6sEclHxX1l0Eem9k	false	-	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P02794	uniprotkb:P59046	intact:EBI-713259|uniprotkb:Q3KRA8|uniprotkb:Q3SWW1|ensembl:ENSP00000273550|ensembl:ENSP00000484477|uniprotkb:B3KNR5	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:frih_human(display_long)|uniprotkb:Cell proliferation-inducing gene 15 protein(gene name synonym)|uniprotkb:FTH1(gene name)|psi-mi:FTH1(display_short)|uniprotkb:FTH(gene name synonym)|uniprotkb:FTHL6(gene name synonym)|uniprotkb:PIG15(orf name)|uniprotkb:OK/SW-cl.84(orf name)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499350|imex:IM-27886-93	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002023.2|ensembl:ENSG00000167996(gene)|ensembl:ENST00000273550(transcript)|ensembl:ENST00000620041(transcript)|go:"GO:0004322"(ferroxidase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006880"(intracellular sequestering of iron ion)|go:"GO:0006955"(immune response)|go:"GO:0008043"(intracellular ferritin complex)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008199"(ferric iron binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0044754"(autolysosome)|mint:P02794|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:1FHA|rcsb pdb:2CEI|rcsb pdb:2CHI|rcsb pdb:2CIH|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001519(Ferritin, N-terminal)|interpro:IPR008331(Ferritin and Dps)|interpro:IPR009040(Ferritin-like)|interpro:IPR009078(Ferritin/ribonucleotide reductase-like)|interpro:IPR012347(Ferritin-related)|interpro:IPR014034(Ferritin, conserved site)|rcsb pdb:2CLU|rcsb pdb:2CN6|rcsb pdb:2CN7|rcsb pdb:2FHA|rcsb pdb:2IU2|rcsb pdb:2Z6M|rcsb pdb:3AJO|rcsb pdb:3AJP|rcsb pdb:3AJQ|rcsb pdb:3ERZ|rcsb pdb:3ES3|rcsb pdb:4DYX|rcsb pdb:4DYY|rcsb pdb:4DYZ|rcsb pdb:4Y08|rcsb pdb:4YKH|rcsb pdb:4ZJK|rcsb pdb:5CMQ|rcsb pdb:5CMR|rcsb pdb:5GN8|rcsb pdb:5GOU|rcsb pdb:5JKK|rcsb pdb:5JKL|rcsb pdb:5JKM|rcsb pdb:5N26|rcsb pdb:5N27|rcsb pdb:5UP7|rcsb pdb:5UP8|rcsb pdb:5UP9|rcsb pdb:5VTD|rcsb pdb:5XB1|rcsb pdb:5YI5|rcsb pdb:5ZND|rcsb pdb:6B8F|rcsb pdb:6B8G|rcsb pdb:4DZ0|rcsb pdb:6FTV|rcsb pdb:6GSR|rcsb pdb:6H5I|rcsb pdb:6H6T|rcsb pdb:6H6U|rcsb pdb:6IPC|rcsb pdb:6IPO|rcsb pdb:6IPP|rcsb pdb:6IPQ|rcsb pdb:6J4A|rcsb pdb:6J7G|rcsb pdb:6JOB|rcsb pdb:6JPS|rcsb pdb:6KE2|rcsb pdb:6KE4|rcsb pdb:4OYN|rcsb pdb:6M52|rcsb pdb:6M54|rcsb pdb:6WYF|rcsb pdb:6WYG|rcsb pdb:6WYH|rcsb pdb:6Z6U|rcsb pdb:6Z9E|rcsb pdb:6Z9F|rcsb pdb:7A6A|rcsb pdb:7A6B|rcsb pdb:7CK8|rcsb pdb:7CK9|rcsb pdb:7JGK|rcsb pdb:7JGL|rcsb pdb:7JGM|rcsb pdb:7JGN|rcsb pdb:7JGO|rcsb pdb:7JGP|rcsb pdb:7JGQ|rcsb pdb:7K26|rcsb pdb:7K3V|rcsb pdb:7K3W|reactome:R-HSA-3000480|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-917937|dip:DIP-38301N	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/08	rogid:TchHgRpv+inA8BQ5i0OHaa267tQ9606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:FPR18SQB0dE4s7JRinNDozIQyvc	false	-	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Y546	uniprotkb:P59046	intact:EBI-20720831|ensembl:ENSP00000318185|ensembl:ENSP00000360421|uniprotkb:D3DQ46|uniprotkb:Q8N2Q8	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:lrc42_human(display_long)|uniprotkb:LRRC42(gene name)|psi-mi:LRRC42(display_short)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499356|imex:IM-27886-95	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000116212(gene)|ensembl:ENST00000319223(transcript)|ensembl:ENST00000371370(transcript)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR032675|interpro:IPR039631|refseq:NP_001243338.1|refseq:NP_443172.1|refseq:XP_006710390.1|refseq:XP_006710391.1	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/08	rogid:mg4TW1YX3ztCDNbt0SH/GUGn/+09606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:8f9IFUnJOkOn34eUzJ6eO4xGuQo	false	-	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q86UX7	uniprotkb:P59046	intact:EBI-373158|uniprotkb:Q8IUA1|uniprotkb:Q8N207|uniprotkb:Q9BT48|ensembl:ENSP00000279227	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:urp2_human(display_long)|uniprotkb:FERMT3(gene name)|psi-mi:FERMT3(display_short)|uniprotkb:KIND3(gene name synonym)|uniprotkb:MIG2B(gene name synonym)|uniprotkb:URP2(gene name synonym)|uniprotkb:Unc-112-related protein 2(gene name synonym)|uniprotkb:Kindlin-3(gene name synonym)|uniprotkb:MIG2-like protein(gene name synonym)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499362|imex:IM-27886-35	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_113659.3|refseq:NP_848537.1|refseq:XP_011543596.1|ensembl:ENSG00000149781(gene)|ensembl:ENST00000279227(transcript)|go:"GO:0002102"(podosome)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0030055"(cell-substrate junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0033622"(integrin activation)|go:"GO:0033632"(regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042995"(cell projection)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019748|interpro:IPR019749|interpro:IPR035963|interpro:IPR037837|interpro:IPR037843|interpro:IPR040790|rcsb pdb:2YS3|rcsb pdb:6V97|rcsb pdb:6V9G|rcsb pdb:7C3M|reactome:R-HSA-114608|refseq:XP_016873887.1	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/08	rogid:BDLaeBD6Ycz4HAh/4QlZeSZurxY9606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:DyBzVyy/Nq0PfVluKx9BClpi+cg	false	-	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q3B8N2	uniprotkb:P59046	intact:EBI-10240775|uniprotkb:A6NLF8|uniprotkb:A8K2J8|ensembl:ENSP00000388841	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:leg9b_human(display_long)|uniprotkb:LGALS9B(gene name)|psi-mi:LGALS9B(display_short)|uniprotkb:Galectin-9-like protein A(gene name synonym)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499368|imex:IM-27886-73	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001036150.1|ensembl:ENSG00000170298(gene)|ensembl:ENST00000423676(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016936"(galactoside binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|interpro:IPR001079(Galectin, galactose-binding lectin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR044156	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/08	rogid:ekf2T3ug0FHFNKIFOf9celuHdO49606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:CdEookR3go6uXPtQPBeCKXSwf4M	false	-	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P04179	uniprotkb:P59046	intact:EBI-716989|intact:EBI-1058533|uniprotkb:P78434|uniprotkb:Q16792|uniprotkb:Q5TCM1|uniprotkb:Q96EE6|uniprotkb:Q9P2Z3|uniprotkb:B2R7R1|uniprotkb:E1P5A9|uniprotkb:B3KUK2|uniprotkb:B4E3K9|intact:EBI-11528264|uniprotkb:B4DL20|ensembl:ENSP00000356022|ensembl:ENSP00000446252	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:sodm_human(display_long)|uniprotkb:SOD2(gene name)|psi-mi:SOD2(display_short)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499374|imex:IM-27886-75	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001019637.1|refseq:NP_000627.2|refseq:NP_001019636.1|refseq:NP_001309743.1|refseq:NP_001309744.1|refseq:NP_001309746.1|refseq:NP_001309748.1|refseq:NP_001309749.1|ensembl:ENSG00000112096(gene)|ensembl:ENST00000367055(transcript)|ensembl:ENST00000538183(transcript)|go:"GO:0000303"(response to superoxide)|go:"GO:0001315"(age-dependent response to reactive oxygen species)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0003069"(acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0003677"(DNA binding)|go:"GO:0004784"(superoxide dismutase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0009409"(response to cold)|go:"GO:0010042"(response to manganese ion)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010269"(response to selenium ion)|go:"GO:0010729"(positive regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014823"(response to activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0019825"(oxygen binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032364"(oxygen homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0034021"(response to silicon dioxide)|go:"GO:0035900"(response to isolation stress)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071000"(response to magnetism)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902631"(negative regulation of membrane hyperpolarization)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:1905932"(positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching)|interpro:IPR001189(Manganese and iron superoxide dismutase)|interpro:IPR019831|interpro:IPR019832|interpro:IPR019833|interpro:IPR036314|interpro:IPR036324|mint:P04179|rcsb pdb:1AP5|rcsb pdb:1AP6|rcsb pdb:1EM1|rcsb pdb:1JA8|rcsb pdb:1LUV|rcsb pdb:1LUW|rcsb pdb:1MSD|rcsb pdb:1N0J|rcsb pdb:1N0N|rcsb pdb:1PL4|rcsb pdb:1PM9|rcsb pdb:1QNM|rcsb pdb:1SZX|rcsb pdb:1VAR|rcsb pdb:1XDC|rcsb pdb:1XIL|rcsb pdb:1ZTE|rcsb pdb:1ZUQ|rcsb pdb:2ADP|rcsb pdb:2ADQ|rcsb pdb:2GDS|rcsb pdb:2P4K|rcsb pdb:2QKA|rcsb pdb:2QKC|rcsb pdb:3C3S|rcsb pdb:3C3T|rcsb pdb:5GXO|rcsb pdb:5T30|rcsb pdb:5VF9|rcsb pdb:7KKS|rcsb pdb:7KKU|rcsb pdb:7KKW|rcsb pdb:7KLB|reactome:R-HSA-2151201|reactome:R-HSA-3299685|reactome:R-HSA-8862803|reactome:R-HSA-8950505|rcsb pdb:1ZSP|reactome:R-HSA-9615017	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/08	rogid:W5bvoLylgk4nEcm5peimceKIBbE9606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:nfHAXwm2rr10xLOPxTvoxChqlX4	false	-	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7LFX5	uniprotkb:P59046	intact:EBI-11123530|uniprotkb:O60338|uniprotkb:Q86VM4|uniprotkb:O60474|ensembl:ENSP00000333947|ensembl:ENSP00000402394	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:chstf_human(display_long)|uniprotkb:CHST15(gene name)|psi-mi:CHST15(display_short)|uniprotkb:B-cell RAG-associated gene protein(gene name synonym)|uniprotkb:BRAG(gene name synonym)|uniprotkb:GALNAC4S6ST(gene name synonym)|uniprotkb:KIAA0598(gene name synonym)|uniprotkb:N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase(gene name synonym)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499380|imex:IM-27886-101	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001257693.1|refseq:NP_001257694.1|refseq:NP_056976.2|refseq:XP_005269948.1|refseq:XP_006717954.1|ensembl:ENSG00000182022(gene)|ensembl:ENST00000346248(transcript)|ensembl:ENST00000435907(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019319"(hexose biosynthetic process)|go:"GO:0030206"(chondroitin sulfate biosynthetic process)|go:"GO:0050656"(3'-phosphoadenosine 5'-phosphosulfate binding)|go:"GO:0050659"(N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity)|interpro:IPR027417|reactome:R-HSA-2022870|refseq:XP_016871808.1	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/08	rogid:qz+LLZd4NoSlTVuhML6eZ9cYnGc9606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:VlrEhtSC1Buqy8pHfArOpPkbihs	false	-	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O00165	uniprotkb:P59046	intact:EBI-357001|uniprotkb:A8W4W9|uniprotkb:A8W4X0|uniprotkb:B4DUJ7|uniprotkb:Q5VYD7|uniprotkb:Q5VYD5|uniprotkb:Q96AU4|uniprotkb:Q9BS80|ensembl:ENSP00000329002	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:hax1_human(display_long)|uniprotkb:HAX1(gene name)|psi-mi:HAX1(display_short)|uniprotkb:HS1BP1(gene name synonym)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499386|imex:IM-27886-57	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001018238.1|refseq:NP_006109.2|dip:DIP-36771N|ensembl:ENSG00000143575(gene)|ensembl:ENST00000328703(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR017248(HS1-associating, X-1)|mint:O00165	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/08	rogid:XRyEPYge2cQFiWdmOaiNIAxd1yQ9606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:N+qK201co3zK+IymskP/XXRkVig	false	-	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P10321	uniprotkb:P59046	intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499392|imex:IM-27886-37	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/08	rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:TMgZO+p11FjBZXJ38Z0olLx8DtY	false	-	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q02040	uniprotkb:P59046	intact:EBI-1042725|uniprotkb:Q02832|uniprotkb:Q2TB98|uniprotkb:Q5JQ74|uniprotkb:Q5JQ76|uniprotkb:Q8N6U9|ensembl:ENSP00000324827	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:ak17a_human(display_long)|uniprotkb:AKAP17A(gene name)|psi-mi:AKAP17A(display_short)|uniprotkb:DXYS155E(gene name synonym)|uniprotkb:Protein XE7(gene name synonym)|uniprotkb:B-lymphocyte antigen(gene name synonym)|uniprotkb:721P(gene name synonym)|uniprotkb:SFRS17A(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 17A(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 17A(gene name synonym)|uniprotkb:CXYorf3(gene name synonym)|uniprotkb:XE7(gene name synonym)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499398|imex:IM-27886-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005079.2|ensembl:ENSG00000197976(gene)|ensembl:ENST00000313871(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0007165"(signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0042113"(B cell activation)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0051018"(protein kinase A binding)|interpro:IPR034355|interpro:IPR035979	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/06	rogid:Od9lQN7lrCl0uP/r3m6iX4vtCfg9606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:1XO76WSj4nWeM6h3EX++L7eqgxY	false	-	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P10145	uniprotkb:P59046	intact:EBI-3917999|uniprotkb:Q9UCS0|uniprotkb:Q9UCR8|uniprotkb:Q9C077|uniprotkb:Q6FGF6|uniprotkb:Q96RG6|uniprotkb:B2R4L8|uniprotkb:Q9UCE1|uniprotkb:Q9UCR9|uniprotkb:Q6LAE6|ensembl:ENSP00000306512	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:il8_human(display_long)|uniprotkb:Protein 3-10C(gene name synonym)|uniprotkb:T-cell chemotactic factor(gene name synonym)|uniprotkb:CXCL8(gene name)|psi-mi:CXCL8(display_short)|uniprotkb:C-X-C motif chemokine 8(gene name synonym)|uniprotkb:"Chemokine (C-X-C motif) ligand 8"(gene name synonym)|uniprotkb:Emoctakin(gene name synonym)|uniprotkb:Granulocyte chemotactic protein 1(gene name synonym)|uniprotkb:IL8(gene name synonym)|uniprotkb:Monocyte-derived neutrophil chemotactic factor(gene name synonym)|uniprotkb:Monocyte-derived neutrophil-activating peptide(gene name synonym)|uniprotkb:Neutrophil-activating protein 1(gene name synonym)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499404|imex:IM-27886-77	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000575.1|ensembl:ENSG00000169429(gene)|ensembl:ENST00000307407(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0005153"(interleukin-8 receptor binding)|go:"GO:0005576"(extracellular region)|reactome:R-HSA-6785807|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031623"(receptor internalization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042119"(neutrophil activation)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045091"(regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0006935"(chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000535"(regulation of entry of bacterium into host cell)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR028469|interpro:IPR033899|interpro:IPR036048|rcsb pdb:1ICW|rcsb pdb:1IKL|rcsb pdb:1IKM|rcsb pdb:1IL8|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|rcsb pdb:1ILQ|rcsb pdb:1QE6|rcsb pdb:1ROD|rcsb pdb:2IL8|rcsb pdb:3IL8|rcsb pdb:4XDX|rcsb pdb:5D14|rcsb pdb:5WDZ|rcsb pdb:6LFM|rcsb pdb:6LFO|rcsb pdb:6N2U|rcsb pdb:6WZM|reactome:R-HSA-2559582|reactome:R-HSA-375276|rcsb pdb:1ILP|reactome:R-HSA-380108|reactome:R-HSA-380994|reactome:R-HSA-418594|reactome:R-HSA-6783783|dip:DIP-3778N	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/08	rogid:aC4GQA1hEtGxhjdfmoeStVe8Mf09606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:/y+7OSHeWp1IFn30qnM8H39eMUA	false	-	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P08631	uniprotkb:P59046	intact:EBI-346340|uniprotkb:Q29RX1|uniprotkb:Q2VPE2|uniprotkb:Q504R5|uniprotkb:Q5T7K1|uniprotkb:Q5T7K2|uniprotkb:Q96CC0|uniprotkb:Q9H5Y5|uniprotkb:Q9NUA4|uniprotkb:Q9UMJ5|uniprotkb:B4DQB6|uniprotkb:E1P5M2|uniprotkb:A8K1I1|ensembl:ENSP00000365012	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:hck_human(display_long)|uniprotkb:HCK(gene name)|psi-mi:HCK(display_short)|uniprotkb:Hemopoietic cell kinase(gene name synonym)|uniprotkb:p59-HCK/p60-HCK(gene name synonym)|uniprotkb:Hematopoietic cell kinase(gene name synonym)|uniprotkb:p59Hck(gene name synonym)|uniprotkb:p61Hck(gene name synonym)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499410|imex:IM-27886-39	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001165600.1|refseq:NP_001165601.1|refseq:NP_001165602.1|refseq:NP_001165604.1|refseq:NP_002101.2|dip:DIP-1051N|ensembl:ENSG00000101336(gene)|ensembl:ENST00000375852(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002522"(leukocyte migration involved in immune response)|go:"GO:0002758"(innate immune response-activating signal transduction)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007498"(mesoderm development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030133"(transport vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042995"(cell projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043299"(leukocyte degranulation)|go:"GO:0045087"(innate immune response)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0046777"(protein autophosphorylation)|rcsb pdb:3VS3|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0071801"(regulation of podosome assembly)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035851|interpro:IPR036028|interpro:IPR036860|mint:P08631|rcsb pdb:1AD5|rcsb pdb:1BU1|rcsb pdb:1QCF|rcsb pdb:2C0I|rcsb pdb:2C0O|rcsb pdb:2C0T|rcsb pdb:2HCK|rcsb pdb:2HK5|rcsb pdb:2OI3|rcsb pdb:2OJ2|rcsb pdb:3HCK|rcsb pdb:3NHN|rcsb pdb:3RBB|rcsb pdb:3REA|rcsb pdb:3VS4|rcsb pdb:3VS5|rcsb pdb:3REB|rcsb pdb:3VS6|rcsb pdb:3VRY|rcsb pdb:3VRZ|rcsb pdb:3VS0|rcsb pdb:3VS1|rcsb pdb:3VS2|rcsb pdb:3VS7|rcsb pdb:4HCK|rcsb pdb:4LUD|rcsb pdb:4LUE|rcsb pdb:4ORZ|rcsb pdb:4U5W|rcsb pdb:5H09|rcsb pdb:5H0B|rcsb pdb:5H0G|rcsb pdb:5H0H|rcsb pdb:5HCK|rcsb pdb:5H0E|rcsb pdb:5NUH|rcsb pdb:5ZJ6|reactome:R-HSA-164944|reactome:R-HSA-2029481|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9706374	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:1c,tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/08	rogid:0ppUsdZNQdUtoKG6MdfS1bzOgZc9606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:gk5ub1KTW+Mbju29TAEQFjrU1yY	false	sufficient binding region:487-526	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P59046	uniprotkb:Q01518	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	intact:EBI-2808398|ensembl:ENSP00000361878|ensembl:ENSP00000361883|ensembl:ENSP00000361891|uniprotkb:Q6I9U6|uniprotkb:Q5T0S2|uniprotkb:Q53HR7|uniprotkb:Q5T0S1	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:cap1_human(display_long)|uniprotkb:CAP1(gene name)|psi-mi:CAP1(display_short)|uniprotkb:CAP(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25506779|imex:IM-27886-106	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	ensembl:ENSG00000131236(gene)|ensembl:ENST00000372792(transcript)|ensembl:ENST00000372797(transcript)|ensembl:ENST00000372805(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007165"(signal transduction)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0045761"(regulation of adenylate cyclase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001837(Adenylate cyclase-associated CAP)|interpro:IPR006599(CARP motif)|interpro:IPR013912(Adenylate cyclase-associated CAP,  C-terminal)|interpro:IPR013992(Adenylate cyclase-associated CAP, N-terminal)|interpro:IPR016098(Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal)|interpro:IPR017901|interpro:IPR018106|interpro:IPR028415|interpro:IPR028417|go:"GO:0001667"(ameboidal-type cell migration)|interpro:IPR036222|interpro:IPR036223|mint:Q01518|rcsb pdb:1K8F|reactome:R-HSA-114608|reactome:R-HSA-428890|reactome:R-HSA-6798695|refseq:XP_011538811.1|refseq:XP_011538812.1|refseq:XP_011538813.1|refseq:XP_011538814.1|refseq:XP_011538815.1|refseq:XP_011538816.1|refseq:XP_011538817.1|refseq:NP_001099000.1|refseq:NP_006358.1|refseq:XP_016855556.1|refseq:XP_016855557.1|refseq:XP_016855558.1|refseq:XP_016855559.1|refseq:XP_016855560.1|refseq:XP_016855561.1|refseq:XP_005270425.1|dip:DIP-62063N	-	-	crc64:7789D1FAC0D1AB7B	figure legend:tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/08	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rogid:BXrQm0u+e0xVOl2b+A18GrZy5Eg9606	rigid:lGSH3LJNLSVycwLLMajoLXALhdg	false	sufficient binding region:1-531	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NQ31	uniprotkb:P59046	intact:EBI-517035|uniprotkb:Q8NBS2|uniprotkb:Q8TAC6|uniprotkb:Q8TAD3|uniprotkb:Q8TAE0|ensembl:ENSP00000310459|ensembl:ENSP00000431331	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:akip1_human(display_long)|uniprotkb:Breast cancer-associated gene 3 protein(gene name synonym)|uniprotkb:PKA-interacting protein(gene name synonym)|uniprotkb:AKIP1(gene name)|psi-mi:AKIP1(display_short)|uniprotkb:BCA3(gene name synonym)|uniprotkb:C11orf17(gene name synonym)|uniprotkb:Proline-rich protein BCA3(gene name synonym)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25506790|imex:IM-27886-108	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193575.1|refseq:NP_001193576.1|refseq:NP_001193577.1|refseq:NP_065693.2|refseq:XP_016873500.1|ensembl:ENSG00000166452(gene)|ensembl:ENST00000309377(transcript)|ensembl:ENST00000534147(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|interpro:IPR033214	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/08	rogid:EdMopChLAM1kUZUfo5Z9IBU0Vyg9606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:f4fCfvqwm9ujdbE7CGvdKBaFBho	false	-	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9UHD9	uniprotkb:P59046	intact:EBI-947187|uniprotkb:O94798|uniprotkb:Q9H3W6|uniprotkb:Q9HAZ4|uniprotkb:Q5D027|intact:EBI-28967571|ensembl:ENSP00000345195	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:ubql2_human(display_long)|uniprotkb:UBQLN2(gene name)|psi-mi:UBQLN2(display_short)|uniprotkb:PLIC2(gene name synonym)|uniprotkb:HRIHFB2157(orf name)|uniprotkb:N4BP4(gene name synonym)|uniprotkb:Protein linking IAP with cytoskeleton 2(gene name synonym)|uniprotkb:Ubiquitin-like product Chap1/Dsk2(gene name synonym)|uniprotkb:DSK2 homolog(gene name synonym)|uniprotkb:Chap1(gene name synonym)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25506813|imex:IM-27886-110	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000345195|refseq:NP_038472.2|dip:DIP-42116N|ensembl:ENSG00000188021(gene)|ensembl:ENST00000338222(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:1900186"(negative regulation of clathrin-dependent endocytosis)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1904021"(negative regulation of G protein-coupled receptor internalization)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR000626(Ubiquitin)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028430|interpro:IPR029071|mint:Q9UHD9|rcsb pdb:1J8C|rcsb pdb:2NBV|rcsb pdb:6MUN|reactome:R-HSA-8856825	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:tableS1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/08	rogid:tElcz7gHFkKFVDTz3PXeNcaBP7U9606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:N+JpV9FntCog/loecuadb26IjG8	false	-	sufficient binding region:1-531	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P08631	uniprotkb:P59046	intact:EBI-346340|uniprotkb:Q29RX1|uniprotkb:Q2VPE2|uniprotkb:Q504R5|uniprotkb:Q5T7K1|uniprotkb:Q5T7K2|uniprotkb:Q96CC0|uniprotkb:Q9H5Y5|uniprotkb:Q9NUA4|uniprotkb:Q9UMJ5|uniprotkb:B4DQB6|uniprotkb:E1P5M2|uniprotkb:A8K1I1|ensembl:ENSP00000365012	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:hck_human(display_long)|uniprotkb:HCK(gene name)|psi-mi:HCK(display_short)|uniprotkb:Hemopoietic cell kinase(gene name synonym)|uniprotkb:p59-HCK/p60-HCK(gene name synonym)|uniprotkb:Hematopoietic cell kinase(gene name synonym)|uniprotkb:p59Hck(gene name synonym)|uniprotkb:p61Hck(gene name synonym)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499425|imex:IM-27886-97	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001165600.1|refseq:NP_001165601.1|refseq:NP_001165602.1|refseq:NP_001165604.1|refseq:NP_002101.2|dip:DIP-1051N|ensembl:ENSG00000101336(gene)|ensembl:ENST00000375852(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002522"(leukocyte migration involved in immune response)|go:"GO:0002758"(innate immune response-activating signal transduction)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007498"(mesoderm development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030133"(transport vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042995"(cell projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043299"(leukocyte degranulation)|go:"GO:0045087"(innate immune response)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0046777"(protein autophosphorylation)|rcsb pdb:3VS3|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0071801"(regulation of podosome assembly)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035851|interpro:IPR036028|interpro:IPR036860|mint:P08631|rcsb pdb:1AD5|rcsb pdb:1BU1|rcsb pdb:1QCF|rcsb pdb:2C0I|rcsb pdb:2C0O|rcsb pdb:2C0T|rcsb pdb:2HCK|rcsb pdb:2HK5|rcsb pdb:2OI3|rcsb pdb:2OJ2|rcsb pdb:3HCK|rcsb pdb:3NHN|rcsb pdb:3RBB|rcsb pdb:3REA|rcsb pdb:3VS4|rcsb pdb:3VS5|rcsb pdb:3REB|rcsb pdb:3VS6|rcsb pdb:3VRY|rcsb pdb:3VRZ|rcsb pdb:3VS0|rcsb pdb:3VS1|rcsb pdb:3VS2|rcsb pdb:3VS7|rcsb pdb:4HCK|rcsb pdb:4LUD|rcsb pdb:4LUE|rcsb pdb:4ORZ|rcsb pdb:4U5W|rcsb pdb:5H09|rcsb pdb:5H0B|rcsb pdb:5H0G|rcsb pdb:5H0H|rcsb pdb:5HCK|rcsb pdb:5H0E|rcsb pdb:5NUH|rcsb pdb:5ZJ6|reactome:R-HSA-164944|reactome:R-HSA-2029481|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9706374	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:3,4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/04/04	2020/04/09	rogid:0ppUsdZNQdUtoKG6MdfS1bzOgZc9606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:gk5ub1KTW+Mbju29TAEQFjrU1yY	false	necessary binding region:522-526|mutation with no effect:506-506|mutation disrupting interaction strength:504-504|mutation with no effect:505-505|mutation disrupting interaction strength:507-507|mutation disrupting interaction strength:508-508|mutation with no effect:509-509|mutation with no effect:510-510|mutation disrupting interaction strength:511-511|mutation disrupting interaction strength:512-512|sufficient binding region:496-526	sufficient binding region:1-531	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08631-1	uniprotkb:P59046	intact:EBI-25505953|ensembl:ENSP00000365012	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:p08631-1(display_long)|uniprotkb:Hematopoietic cell kinase(gene name synonym)|uniprotkb:Hemopoietic cell kinase(gene name synonym)|uniprotkb:p59-HCK/p60-HCK(gene name synonym)|uniprotkb:p59Hck(gene name synonym)|uniprotkb:p61Hck(gene name synonym)|uniprotkb:p60-HCK(isoform synonym)|uniprotkb:p61Hck(isoform synonym)|uniprotkb:HCK(gene name)|psi-mi:HCK(display_short)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499469|imex:IM-27886-79	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101336(gene)|ensembl:ENST00000375852(transcript)|intact:EBI-346340(isoform-parent)	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/04/04	2020/04/08	rogid:0ppUsdZNQdUtoKG6MdfS1bzOgZc9606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:gk5ub1KTW+Mbju29TAEQFjrU1yY	false	-	v5 tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Y228	uniprotkb:P59046	intact:EBI-765817|uniprotkb:Q2YDB5|uniprotkb:A6NIU9|uniprotkb:Q4VY06|uniprotkb:Q7Z706|uniprotkb:A1L464|ensembl:ENSP00000355991|ensembl:ENSP00000355992	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:t3jam_human(display_long)|uniprotkb:TRAF3-interacting protein 3(gene name synonym)|uniprotkb:TRAF3IP3(gene name)|psi-mi:TRAF3IP3(display_short)|uniprotkb:T3JAM(gene name synonym)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499475|imex:IM-27886-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079504.2|refseq:NP_001274683.1|refseq:NP_001307072.1|refseq:NP_001307073.1|ensembl:ENSG00000009790(gene)|ensembl:ENST00000367024(transcript)|ensembl:ENST00000367025(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|mint:Q9Y228	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:8b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/04/04	2020/04/05	rogid:KDgxJv66FX+o56QzfysW3BS/tKc9606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:NaezJgYF1viJhLmMikwuX/tVPVo	false	myc tag:n-n|flag tag:n-n	v5 tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P08631	uniprotkb:P59046	intact:EBI-346340|uniprotkb:Q29RX1|uniprotkb:Q2VPE2|uniprotkb:Q504R5|uniprotkb:Q5T7K1|uniprotkb:Q5T7K2|uniprotkb:Q96CC0|uniprotkb:Q9H5Y5|uniprotkb:Q9NUA4|uniprotkb:Q9UMJ5|uniprotkb:B4DQB6|uniprotkb:E1P5M2|uniprotkb:A8K1I1|ensembl:ENSP00000365012	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:hck_human(display_long)|uniprotkb:HCK(gene name)|psi-mi:HCK(display_short)|uniprotkb:Hemopoietic cell kinase(gene name synonym)|uniprotkb:p59-HCK/p60-HCK(gene name synonym)|uniprotkb:Hematopoietic cell kinase(gene name synonym)|uniprotkb:p59Hck(gene name synonym)|uniprotkb:p61Hck(gene name synonym)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499489|imex:IM-27886-99	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001165600.1|refseq:NP_001165601.1|refseq:NP_001165602.1|refseq:NP_001165604.1|refseq:NP_002101.2|dip:DIP-1051N|ensembl:ENSG00000101336(gene)|ensembl:ENST00000375852(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002522"(leukocyte migration involved in immune response)|go:"GO:0002758"(innate immune response-activating signal transduction)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007498"(mesoderm development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030133"(transport vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042995"(cell projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043299"(leukocyte degranulation)|go:"GO:0045087"(innate immune response)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0046777"(protein autophosphorylation)|rcsb pdb:3VS3|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0071801"(regulation of podosome assembly)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035851|interpro:IPR036028|interpro:IPR036860|mint:P08631|rcsb pdb:1AD5|rcsb pdb:1BU1|rcsb pdb:1QCF|rcsb pdb:2C0I|rcsb pdb:2C0O|rcsb pdb:2C0T|rcsb pdb:2HCK|rcsb pdb:2HK5|rcsb pdb:2OI3|rcsb pdb:2OJ2|rcsb pdb:3HCK|rcsb pdb:3NHN|rcsb pdb:3RBB|rcsb pdb:3REA|rcsb pdb:3VS4|rcsb pdb:3VS5|rcsb pdb:3REB|rcsb pdb:3VS6|rcsb pdb:3VRY|rcsb pdb:3VRZ|rcsb pdb:3VS0|rcsb pdb:3VS1|rcsb pdb:3VS2|rcsb pdb:3VS7|rcsb pdb:4HCK|rcsb pdb:4LUD|rcsb pdb:4LUE|rcsb pdb:4ORZ|rcsb pdb:4U5W|rcsb pdb:5H09|rcsb pdb:5H0B|rcsb pdb:5H0G|rcsb pdb:5H0H|rcsb pdb:5HCK|rcsb pdb:5H0E|rcsb pdb:5NUH|rcsb pdb:5ZJ6|reactome:R-HSA-164944|reactome:R-HSA-2029481|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9706374	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:5c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2020/04/04	2020/04/05	rogid:0ppUsdZNQdUtoKG6MdfS1bzOgZc9606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rigid:gk5ub1KTW+Mbju29TAEQFjrU1yY	false	-	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P59046	uniprotkb:P08631	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	intact:EBI-346340|uniprotkb:Q29RX1|uniprotkb:Q2VPE2|uniprotkb:Q504R5|uniprotkb:Q5T7K1|uniprotkb:Q5T7K2|uniprotkb:Q96CC0|uniprotkb:Q9H5Y5|uniprotkb:Q9NUA4|uniprotkb:Q9UMJ5|uniprotkb:B4DQB6|uniprotkb:E1P5M2|uniprotkb:A8K1I1|ensembl:ENSP00000365012	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:hck_human(display_long)|uniprotkb:HCK(gene name)|psi-mi:HCK(display_short)|uniprotkb:Hemopoietic cell kinase(gene name synonym)|uniprotkb:p59-HCK/p60-HCK(gene name synonym)|uniprotkb:Hematopoietic cell kinase(gene name synonym)|uniprotkb:p59Hck(gene name synonym)|uniprotkb:p61Hck(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499500|imex:IM-27886-59	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	refseq:NP_001165600.1|refseq:NP_001165601.1|refseq:NP_001165602.1|refseq:NP_001165604.1|refseq:NP_002101.2|dip:DIP-1051N|ensembl:ENSG00000101336(gene)|ensembl:ENST00000375852(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002522"(leukocyte migration involved in immune response)|go:"GO:0002758"(innate immune response-activating signal transduction)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007498"(mesoderm development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030133"(transport vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042995"(cell projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043299"(leukocyte degranulation)|go:"GO:0045087"(innate immune response)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0046777"(protein autophosphorylation)|rcsb pdb:3VS3|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0071801"(regulation of podosome assembly)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035851|interpro:IPR036028|interpro:IPR036860|mint:P08631|rcsb pdb:1AD5|rcsb pdb:1BU1|rcsb pdb:1QCF|rcsb pdb:2C0I|rcsb pdb:2C0O|rcsb pdb:2C0T|rcsb pdb:2HCK|rcsb pdb:2HK5|rcsb pdb:2OI3|rcsb pdb:2OJ2|rcsb pdb:3HCK|rcsb pdb:3NHN|rcsb pdb:3RBB|rcsb pdb:3REA|rcsb pdb:3VS4|rcsb pdb:3VS5|rcsb pdb:3REB|rcsb pdb:3VS6|rcsb pdb:3VRY|rcsb pdb:3VRZ|rcsb pdb:3VS0|rcsb pdb:3VS1|rcsb pdb:3VS2|rcsb pdb:3VS7|rcsb pdb:4HCK|rcsb pdb:4LUD|rcsb pdb:4LUE|rcsb pdb:4ORZ|rcsb pdb:4U5W|rcsb pdb:5H09|rcsb pdb:5H0B|rcsb pdb:5H0G|rcsb pdb:5H0H|rcsb pdb:5HCK|rcsb pdb:5H0E|rcsb pdb:5NUH|rcsb pdb:5ZJ6|reactome:R-HSA-164944|reactome:R-HSA-2029481|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9706374	-	-	-	figure legend:5d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u937)|taxid:9606(Homo sapiens histiocytic lymphoma cells)	-	2020/04/04	2020/04/05	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rogid:0ppUsdZNQdUtoKG6MdfS1bzOgZc9606	rigid:gk5ub1KTW+Mbju29TAEQFjrU1yY	false	flag tag:n-n	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P59046	uniprotkb:P08631-1	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	intact:EBI-25505953|ensembl:ENSP00000365012	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:p08631-1(display_long)|uniprotkb:Hematopoietic cell kinase(gene name synonym)|uniprotkb:Hemopoietic cell kinase(gene name synonym)|uniprotkb:p59-HCK/p60-HCK(gene name synonym)|uniprotkb:p59Hck(gene name synonym)|uniprotkb:p61Hck(gene name synonym)|uniprotkb:p60-HCK(isoform synonym)|uniprotkb:p61Hck(isoform synonym)|uniprotkb:HCK(gene name)|psi-mi:HCK(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:1262"(I2D)	intact:EBI-25499522|imex:IM-27886-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	ensembl:ENSG00000101336(gene)|ensembl:ENST00000375852(transcript)|intact:EBI-346340(isoform-parent)	-	-	-	figure legend:5e,s1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/04/04	2020/04/08	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rogid:0ppUsdZNQdUtoKG6MdfS1bzOgZc9606	rigid:gk5ub1KTW+Mbju29TAEQFjrU1yY	false	flag tag:n-n	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P59046	uniprotkb:P08631-2	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	intact:EBI-9834454|ensembl:ENSP00000429848|ensembl:ENSP00000486627	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:p08631-2(display_long)|uniprotkb:p59-HCK(isoform synonym)|uniprotkb:p59Hck(isoform synonym)|uniprotkb:HCK(gene name)|psi-mi:HCK(display_short)|uniprotkb:Hematopoietic cell kinase(gene name synonym)|uniprotkb:Hemopoietic cell kinase(gene name synonym)|uniprotkb:p59-HCK/p60-HCK(gene name synonym)|uniprotkb:p59Hck(gene name synonym)|uniprotkb:p61Hck(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:1262"(I2D)	intact:EBI-25505980|imex:IM-27886-102	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	uniprotkb:P08631-2(isoform-parent)|intact:EBI-346340(isoform-parent)|ensembl:ENSG00000101336(gene)|ensembl:ENST00000520553(transcript)|ensembl:ENST00000629881(transcript)	-	-	isoform-comment:Initiator Met-1 is removed. Contains a N-myristoyl glycine at position 2. Contains a S-palmitoyl cysteine at position 3.	figure legend:5e,s1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/04/04	2020/04/08	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rogid:qSgfntp+jqdyi7qsc7u7UA7ylO09606	rigid:A5r4+Ov8jT6wQlBqkVnKQbw/Znc	false	flag tag:n-n	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P59046	uniprotkb:P08103	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	intact:EBI-6248894|uniprotkb:Q0VH03|uniprotkb:Q3UD17	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:hck_mouse(display_long)|uniprotkb:Hck(gene name)|psi-mi:Hck(display_short)|uniprotkb:B-cell/myeloid kinase(gene name synonym)|uniprotkb:Hematopoietic cell kinase(gene name synonym)|uniprotkb:Hemopoietic cell kinase(gene name synonym)|uniprotkb:p56-HCK/p59-HCK(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhang et al. (2019)	pubmed:32226298|imex:IM-27886	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-25506031|imex:IM-27886-104	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0071801"(regulation of podosome assembly)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|reactome:R-MMU-2029481|reactome:R-MMU-912631|reactome:R-MMU-9674555|reactome:R-MMU-9705462|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005901"(caveola)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005925"(focal adhesion)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006887"(exocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030133"(transport vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0042995"(cell projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045087"(innate immune response)|go:"GO:0046777"(protein autophosphorylation)|mint:P08103|refseq:NP_001165588.1|refseq:NP_034537.2|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR020635|interpro:IPR035851|interpro:IPR036028|interpro:IPR036860	-	-	-	figure legend:5b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-raw264_7)|taxid:10090(Mus musculus monocyte macrophage cell line RAW264)	-	2020/04/04	2020/04/09	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	rogid:ZkVHYxfS6PGWqyvA53/MKE5mv5A10090	rigid:euJ7iRZeYbV46G8Z86d91sA4/Ug	false	flag tag:n-n	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)