#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q06413	uniprotkb:Q05086	intact:EBI-2684075|uniprotkb:D7F7N5|uniprotkb:F8W7V7|uniprotkb:C9JMZ0|ensembl:ENSP00000396219|ensembl:ENSP00000421925|ensembl:ENSP00000490473	intact:EBI-954357|ensembl:ENSP00000497594|uniprotkb:P78355|uniprotkb:Q93066|uniprotkb:Q9UEP4|uniprotkb:Q9UEP5|uniprotkb:Q9UEP6|uniprotkb:Q9UEP7|uniprotkb:Q9UEP8|uniprotkb:Q9UEP9|uniprotkb:A8K8Z9	psi-mi:mef2c_human(display_long)|uniprotkb:MEF2C(gene name)|psi-mi:MEF2C(display_short)|uniprotkb:Myocyte enhancer factor 2C(gene name synonym)	psi-mi:ube3a_human(display_long)|uniprotkb:E6AP ubiquitin-protein ligase(gene name synonym)|uniprotkb:Oncogenic protein-associated protein E6-AP(gene name synonym)|uniprotkb:Human papillomavirus E6-associated protein(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-54(gene name synonym)|uniprotkb:UBE3A(gene name)|psi-mi:UBE3A(display_short)|uniprotkb:E6AP(gene name synonym)|uniprotkb:EPVE6AP(gene name synonym)|uniprotkb:HPVE6A(gene name synonym)|uniprotkb:HECT-type ubiquitin transferase E3A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Straub et al. (2018)	pubmed:31988313|imex:IM-28565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26521074|imex:IM-28565-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011541702.1|refseq:XP_011541698.1|refseq:NP_001294931.1|refseq:NP_001124477.1|refseq:NP_001180276.1|refseq:NP_001180277.1|refseq:NP_001180278.1|refseq:NP_001180279.1|refseq:NP_002388.2|refseq:XP_005248568.1|refseq:XP_006714682.1|refseq:XP_006714688.1|refseq:XP_016864967.1|refseq:XP_016864968.1|refseq:XP_016864969.1|refseq:XP_016864970.1|dip:DIP-40857N|refseq:XP_016864965.1|refseq:XP_016864966.1|ensembl:ENSG00000081189(gene)|ensembl:ENST00000437473(transcript)|ensembl:ENST00000504921(transcript)|ensembl:ENST00000636294(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001764"(neuron migration)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0001958"(endochondral ossification)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002467"(germinal center formation)|go:"GO:0002634"(regulation of germinal center formation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003138"(primary heart field specification)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003185"(sinoatrial valve morphogenesis)|go:"GO:0003211"(cardiac ventricle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0016528"(sarcoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0014902"(myotube differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035690"|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048666"(neuron development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0055012"(ventricular cardiac muscle cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072102"(glomerulus morphogenesis)|go:"GO:0072160"(nephron tubule epithelial cell differentiation)|go:"GO:0098794"(postsynapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000111"(positive regulation of macrophage apoptotic process)|go:"GO:0060025"(regulation of synaptic activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007517"(muscle organ development)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007521"(muscle cell fate determination)|go:"GO:0007611"(learning or memory)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:2000987"(positive regulation of behavioral fear response)|go:"GO:2001013"(epithelial cell proliferation involved in renal tubule morphogenesis)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)|interpro:IPR002100(Transcription factor, MADS-box)|interpro:IPR022102|interpro:IPR033896|interpro:IPR036879|mint:Q06413|reactome:R-HSA-198753|reactome:R-HSA-2151201|reactome:R-HSA-400253|reactome:R-HSA-525793|reactome:R-HSA-9022707|reactome:R-HSA-9707616|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:0003700"(DNA-binding transcription factor activity)	go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060736"(prostate gland growth)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061743"(motor learning)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:1905528"(positive regulation of Golgi lumen acidification)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000058"(regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000569(HECT)|interpro:IPR017134(Ubiquitin-protein ligase E6-AP)|interpro:IPR032353|interpro:IPR035983|interpro:IPR042556|mint:Q05086|rcsb pdb:1C4Z|rcsb pdb:1D5F|rcsb pdb:1EQX|rcsb pdb:2KR1|rcsb pdb:4GIZ|rcsb pdb:4XR8|rcsb pdb:6SJV|rcsb pdb:6SLM|rcsb pdb:6TGK|rcsb pdb:6U19|reactome:R-HSA-983168|ensembl:ENSG00000114062(gene)|ensembl:ENST00000650110(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007420"(brain development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032570"(response to progesterone)|go:"GO:0035037"(sperm entry)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0042220"(response to cocaine)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048511"(rhythmic process)|refseq:NP_000453.2|refseq:NP_570853.1|refseq:NP_570854.1|refseq:XP_016878033.1|refseq:XP_016878034.1|refseq:XP_011520296.1|refseq:XP_011520297.1|refseq:XP_016878035.1|refseq:XP_016878036.1|refseq:XP_016878037.1|refseq:XP_016878038.1|refseq:XP_016878039.1|dip:DIP-6002N|refseq:XP_005268324.1|refseq:XP_005268325.1|refseq:XP_005268326.1|refseq:XP_005268327.1|refseq:XP_005268328.1|refseq:XP_006720738.1|refseq:XP_006720739.1|refseq:XP_016878040.1|refseq:XP_016878041.1|refseq:XP_016878042.1|refseq:XP_016878043.1|refseq:XP_016878044.1	-	-	-	figure legend:F4B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2020/12/10	2020/12/10	rogid:vZxaYdzMYwHDAZZItu8N7SWZPic9606	rogid:w9T67+NDlHSd1tR+FgcX3LI1zpQ9606	rigid:5ZFZglLAmDlVcCe+fmf6LG2/a4w	false	ha tag:c-c	myc tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q06413	uniprotkb:Q05086	intact:EBI-2684075|uniprotkb:D7F7N5|uniprotkb:F8W7V7|uniprotkb:C9JMZ0|ensembl:ENSP00000396219|ensembl:ENSP00000421925|ensembl:ENSP00000490473	intact:EBI-954357|ensembl:ENSP00000497594|uniprotkb:P78355|uniprotkb:Q93066|uniprotkb:Q9UEP4|uniprotkb:Q9UEP5|uniprotkb:Q9UEP6|uniprotkb:Q9UEP7|uniprotkb:Q9UEP8|uniprotkb:Q9UEP9|uniprotkb:A8K8Z9	psi-mi:mef2c_human(display_long)|uniprotkb:MEF2C(gene name)|psi-mi:MEF2C(display_short)|uniprotkb:Myocyte enhancer factor 2C(gene name synonym)	psi-mi:ube3a_human(display_long)|uniprotkb:E6AP ubiquitin-protein ligase(gene name synonym)|uniprotkb:Oncogenic protein-associated protein E6-AP(gene name synonym)|uniprotkb:Human papillomavirus E6-associated protein(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-54(gene name synonym)|uniprotkb:UBE3A(gene name)|psi-mi:UBE3A(display_short)|uniprotkb:E6AP(gene name synonym)|uniprotkb:EPVE6AP(gene name synonym)|uniprotkb:HPVE6A(gene name synonym)|uniprotkb:HECT-type ubiquitin transferase E3A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Straub et al. (2018)	pubmed:31988313|imex:IM-28565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26521082|imex:IM-28565-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011541702.1|refseq:XP_011541698.1|refseq:NP_001294931.1|refseq:NP_001124477.1|refseq:NP_001180276.1|refseq:NP_001180277.1|refseq:NP_001180278.1|refseq:NP_001180279.1|refseq:NP_002388.2|refseq:XP_005248568.1|refseq:XP_006714682.1|refseq:XP_006714688.1|refseq:XP_016864967.1|refseq:XP_016864968.1|refseq:XP_016864969.1|refseq:XP_016864970.1|dip:DIP-40857N|refseq:XP_016864965.1|refseq:XP_016864966.1|ensembl:ENSG00000081189(gene)|ensembl:ENST00000437473(transcript)|ensembl:ENST00000504921(transcript)|ensembl:ENST00000636294(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001764"(neuron migration)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0001958"(endochondral ossification)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002467"(germinal center formation)|go:"GO:0002634"(regulation of germinal center formation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003138"(primary heart field specification)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003185"(sinoatrial valve morphogenesis)|go:"GO:0003211"(cardiac ventricle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0016528"(sarcoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0014902"(myotube differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035690"|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048666"(neuron development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0055012"(ventricular cardiac muscle cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072102"(glomerulus morphogenesis)|go:"GO:0072160"(nephron tubule epithelial cell differentiation)|go:"GO:0098794"(postsynapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000111"(positive regulation of macrophage apoptotic process)|go:"GO:0060025"(regulation of synaptic activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007517"(muscle organ development)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007521"(muscle cell fate determination)|go:"GO:0007611"(learning or memory)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:2000987"(positive regulation of behavioral fear response)|go:"GO:2001013"(epithelial cell proliferation involved in renal tubule morphogenesis)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)|interpro:IPR002100(Transcription factor, MADS-box)|interpro:IPR022102|interpro:IPR033896|interpro:IPR036879|mint:Q06413|reactome:R-HSA-198753|reactome:R-HSA-2151201|reactome:R-HSA-400253|reactome:R-HSA-525793|reactome:R-HSA-9022707|reactome:R-HSA-9707616|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:0003700"(DNA-binding transcription factor activity)	go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060736"(prostate gland growth)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061743"(motor learning)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:1905528"(positive regulation of Golgi lumen acidification)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000058"(regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000569(HECT)|interpro:IPR017134(Ubiquitin-protein ligase E6-AP)|interpro:IPR032353|interpro:IPR035983|interpro:IPR042556|mint:Q05086|rcsb pdb:1C4Z|rcsb pdb:1D5F|rcsb pdb:1EQX|rcsb pdb:2KR1|rcsb pdb:4GIZ|rcsb pdb:4XR8|rcsb pdb:6SJV|rcsb pdb:6SLM|rcsb pdb:6TGK|rcsb pdb:6U19|reactome:R-HSA-983168|ensembl:ENSG00000114062(gene)|ensembl:ENST00000650110(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007420"(brain development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032570"(response to progesterone)|go:"GO:0035037"(sperm entry)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0042220"(response to cocaine)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048511"(rhythmic process)|refseq:NP_000453.2|refseq:NP_570853.1|refseq:NP_570854.1|refseq:XP_016878033.1|refseq:XP_016878034.1|refseq:XP_011520296.1|refseq:XP_011520297.1|refseq:XP_016878035.1|refseq:XP_016878036.1|refseq:XP_016878037.1|refseq:XP_016878038.1|refseq:XP_016878039.1|dip:DIP-6002N|refseq:XP_005268324.1|refseq:XP_005268325.1|refseq:XP_005268326.1|refseq:XP_005268327.1|refseq:XP_005268328.1|refseq:XP_006720738.1|refseq:XP_006720739.1|refseq:XP_016878040.1|refseq:XP_016878041.1|refseq:XP_016878042.1|refseq:XP_016878043.1|refseq:XP_016878044.1	-	-	-	figure legend:F4B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2020/12/10	2020/12/10	rogid:vZxaYdzMYwHDAZZItu8N7SWZPic9606	rogid:w9T67+NDlHSd1tR+FgcX3LI1zpQ9606	rigid:5ZFZglLAmDlVcCe+fmf6LG2/a4w	false	ha tag:c-c	myc tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q06413	uniprotkb:Q05086	intact:EBI-2684075|uniprotkb:D7F7N5|uniprotkb:F8W7V7|uniprotkb:C9JMZ0|ensembl:ENSP00000396219|ensembl:ENSP00000421925|ensembl:ENSP00000490473	intact:EBI-954357|ensembl:ENSP00000497594|uniprotkb:P78355|uniprotkb:Q93066|uniprotkb:Q9UEP4|uniprotkb:Q9UEP5|uniprotkb:Q9UEP6|uniprotkb:Q9UEP7|uniprotkb:Q9UEP8|uniprotkb:Q9UEP9|uniprotkb:A8K8Z9	psi-mi:mef2c_human(display_long)|uniprotkb:MEF2C(gene name)|psi-mi:MEF2C(display_short)|uniprotkb:Myocyte enhancer factor 2C(gene name synonym)	psi-mi:ube3a_human(display_long)|uniprotkb:E6AP ubiquitin-protein ligase(gene name synonym)|uniprotkb:Oncogenic protein-associated protein E6-AP(gene name synonym)|uniprotkb:Human papillomavirus E6-associated protein(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-54(gene name synonym)|uniprotkb:UBE3A(gene name)|psi-mi:UBE3A(display_short)|uniprotkb:E6AP(gene name synonym)|uniprotkb:EPVE6AP(gene name synonym)|uniprotkb:HPVE6A(gene name synonym)|uniprotkb:HECT-type ubiquitin transferase E3A(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Straub et al. (2018)	pubmed:31988313|imex:IM-28565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-26521090|imex:IM-28565-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011541702.1|refseq:XP_011541698.1|refseq:NP_001294931.1|refseq:NP_001124477.1|refseq:NP_001180276.1|refseq:NP_001180277.1|refseq:NP_001180278.1|refseq:NP_001180279.1|refseq:NP_002388.2|refseq:XP_005248568.1|refseq:XP_006714682.1|refseq:XP_006714688.1|refseq:XP_016864967.1|refseq:XP_016864968.1|refseq:XP_016864969.1|refseq:XP_016864970.1|dip:DIP-40857N|refseq:XP_016864965.1|refseq:XP_016864966.1|ensembl:ENSG00000081189(gene)|ensembl:ENST00000437473(transcript)|ensembl:ENST00000504921(transcript)|ensembl:ENST00000636294(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001764"(neuron migration)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0001958"(endochondral ossification)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002467"(germinal center formation)|go:"GO:0002634"(regulation of germinal center formation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003138"(primary heart field specification)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003185"(sinoatrial valve morphogenesis)|go:"GO:0003211"(cardiac ventricle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0016528"(sarcoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0014902"(myotube differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035690"|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048666"(neuron development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0055012"(ventricular cardiac muscle cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072102"(glomerulus morphogenesis)|go:"GO:0072160"(nephron tubule epithelial cell differentiation)|go:"GO:0098794"(postsynapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000111"(positive regulation of macrophage apoptotic process)|go:"GO:0060025"(regulation of synaptic activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007517"(muscle organ development)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007521"(muscle cell fate determination)|go:"GO:0007611"(learning or memory)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:2000987"(positive regulation of behavioral fear response)|go:"GO:2001013"(epithelial cell proliferation involved in renal tubule morphogenesis)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)|interpro:IPR002100(Transcription factor, MADS-box)|interpro:IPR022102|interpro:IPR033896|interpro:IPR036879|mint:Q06413|reactome:R-HSA-198753|reactome:R-HSA-2151201|reactome:R-HSA-400253|reactome:R-HSA-525793|reactome:R-HSA-9022707|reactome:R-HSA-9707616|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:0003700"(DNA-binding transcription factor activity)	go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060736"(prostate gland growth)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061743"(motor learning)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:1905528"(positive regulation of Golgi lumen acidification)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000058"(regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000569(HECT)|interpro:IPR017134(Ubiquitin-protein ligase E6-AP)|interpro:IPR032353|interpro:IPR035983|interpro:IPR042556|mint:Q05086|rcsb pdb:1C4Z|rcsb pdb:1D5F|rcsb pdb:1EQX|rcsb pdb:2KR1|rcsb pdb:4GIZ|rcsb pdb:4XR8|rcsb pdb:6SJV|rcsb pdb:6SLM|rcsb pdb:6TGK|rcsb pdb:6U19|reactome:R-HSA-983168|ensembl:ENSG00000114062(gene)|ensembl:ENST00000650110(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007420"(brain development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032570"(response to progesterone)|go:"GO:0035037"(sperm entry)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0042220"(response to cocaine)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048511"(rhythmic process)|refseq:NP_000453.2|refseq:NP_570853.1|refseq:NP_570854.1|refseq:XP_016878033.1|refseq:XP_016878034.1|refseq:XP_011520296.1|refseq:XP_011520297.1|refseq:XP_016878035.1|refseq:XP_016878036.1|refseq:XP_016878037.1|refseq:XP_016878038.1|refseq:XP_016878039.1|dip:DIP-6002N|refseq:XP_005268324.1|refseq:XP_005268325.1|refseq:XP_005268326.1|refseq:XP_005268327.1|refseq:XP_005268328.1|refseq:XP_006720738.1|refseq:XP_006720739.1|refseq:XP_016878040.1|refseq:XP_016878041.1|refseq:XP_016878042.1|refseq:XP_016878043.1|refseq:XP_016878044.1	go:"GO:0005634"(nucleus)	-	-	figure legend:F4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2020/12/10	2020/12/10	rogid:vZxaYdzMYwHDAZZItu8N7SWZPic9606	rogid:w9T67+NDlHSd1tR+FgcX3LI1zpQ9606	rigid:5ZFZglLAmDlVcCe+fmf6LG2/a4w	false	ha tag:c-c	myc tag:c-c	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)