#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q04656	uniprotkb:O00244	intact:EBI-7706409|ensembl:ENSP00000345728|intact:MINT-106053|uniprotkb:B1AT72|uniprotkb:Q9BYY8|uniprotkb:O00745|uniprotkb:O00227	intact:EBI-10179267|uniprotkb:Q2M1R6|uniprotkb:A8KAJ8|uniprotkb:D3DQI2|uniprotkb:Q56AP3|ensembl:ENSP00000316854|ensembl:ENSP00000429814|ensembl:ENSP00000430598	psi-mi:atp7a_human(display_long)|uniprotkb:ATP7A(gene name)|psi-mi:ATP7A(display_short)|uniprotkb:MC1(gene name synonym)|uniprotkb:MNK(gene name synonym)|uniprotkb:Copper pump 1(gene name synonym)|uniprotkb:Menkes disease-associated protein(gene name synonym)	psi-mi:atox1_human(display_long)|uniprotkb:ATOX1(gene name)|psi-mi:ATOX1(display_short)|uniprotkb:HAH1(gene name synonym)|uniprotkb:Metal transport protein ATX1(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Blockhuys et al. (2020)	pubmed:31932435|imex:IM-27669	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-25406859|imex:IM-27669-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000165240(gene)|ensembl:ENST00000341514(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001889"(liver development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0005375"(copper ion transmembrane transporter activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006568"(tryptophan metabolic process)|go:"GO:0006584"(catecholamine metabolic process)|go:"GO:0006825"(copper ion transport)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0007626"(locomotory behavior)|go:"GO:0010041"("response to iron(III) ion")|go:"GO:0010042"(response to manganese ion)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015677"(copper ion import)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016532"(superoxide dismutase copper chaperone activity)|go:"GO:0018205"(peptidyl-lysine modification)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0021860"(pyramidal neuron development)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031526"(brush border membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032767"(copper-dependent protein binding)|go:"GO:0032773"(positive regulation of tyrosinase activity)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|go:"GO:0033162"(melanosome membrane)|go:"GO:0034760"(negative regulation of iron ion transmembrane transport)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042093"(T-helper cell differentiation)|go:"GO:0042414"(epinephrine metabolic process)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043204"(perikaryon)|go:"GO:0043473"(pigmentation)|go:"GO:0043588"(skin development)|go:"GO:0043682"(P-type divalent copper transporter activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051087"(chaperone binding)|go:"GO:0051216"(cartilage development)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051542"(elastin biosynthetic process)|go:"GO:0060003"(copper ion export)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071279"(cellular response to cobalt ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071281"(cellular response to iron ion)|go:"GO:0071284"(cellular response to lead ion)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0140581"(P-type monovalent copper transporter activity)|go:"GO:1903036"(positive regulation of response to wounding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1904959"(regulation of cytochrome-c oxidase activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006121(Heavy metal transport/detoxification protein)|interpro:IPR006122(Copper ion-binding)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR017969|interpro:IPR018303|rcsb pdb:1S6U|rcsb pdb:1Y3J|interpro:IPR023298|interpro:IPR023299|interpro:IPR027256|rcsb pdb:1Y3K|interpro:IPR036163|rcsb pdb:1YJR|rcsb pdb:1YJT|rcsb pdb:1YJU|rcsb pdb:1YJV|rcsb pdb:2AW0|rcsb pdb:2G9O|rcsb pdb:2GA7|interpro:IPR036412|interpro:IPR044492|rcsb pdb:1AW0|rcsb pdb:1KVI|rcsb pdb:2K1R|rcsb pdb:2KIJ|rcsb pdb:2KMV|rcsb pdb:2KMX|rcsb pdb:3CJK|rcsb pdb:5T7L|reactome:R-HSA-3299685|reactome:R-HSA-6803544|reactome:R-HSA-936837|rcsb pdb:1KVJ|rcsb pdb:1Q8L|rcsb pdb:1S6O|refseq:NP_000043.4|refseq:NP_001269153.1	refseq:NP_004036.1|ensembl:ENSG00000177556(gene)|ensembl:ENST00000313115(transcript)|ensembl:ENST00000522710(transcript)|ensembl:ENST00000524142(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0006825"(copper ion transport)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0016530"(metallochaperone activity)|go:"GO:0016531"(copper chaperone activity)|go:"GO:0032767"(copper-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051117"(ATPase binding)|go:"GO:0060003"(copper ion export)|go:"GO:1903136"(cuprous ion binding)|interpro:IPR006121(Heavy metal transport/detoxification protein)|interpro:IPR017969|interpro:IPR036163|rcsb pdb:1FE0|rcsb pdb:1FE4|rcsb pdb:1FEE|rcsb pdb:1TL4|rcsb pdb:1TL5|rcsb pdb:2K1R|rcsb pdb:2LQ9|rcsb pdb:3CJK|rcsb pdb:3IWL|rcsb pdb:3IWX|rcsb pdb:4QOT|rcsb pdb:4YDX|rcsb pdb:4YEA|rcsb pdb:5F0W|rcsb pdb:5T7L|reactome:R-HSA-3299685|reactome:R-HSA-6803544	-	comment:mint|function:May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells|function:"Defects in ATP7A are the cause of Menkes syndrome (MD) [MIM:309400]; also known as kinky hair disease. MD is an X-linked recessive disease characterized by progressive neurodegeneration and connective-tissue disturbances: focal cerebral and cerebellar degeneration, early retardation in growth, peculiar hair, hypopigmentation, cutis laxa, vascular complications and death in early childhood. It is due to a defect in absorption and transport of copper"|function:"Defects in ATP7A are the cause of occipital horn syndrome (OHS) [MIM:304150]; also known as X-linked cutis laxa. Common features are unusual facial appearance, skeletal abnormalities, chronic diarrhea and genitourinary defects. The skeletal abnormalities included occipital horns, short, broad clavicles, deformed radii, ulnae and humeri, narrowing of the rib cage, undercalcified long bones with thin cortical walls and coxa valga"	-	figure legend:Fig. 3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mda_mb_231)|taxid:9606(Homo sapiens Caucasian breast adenocarcinoma)	-	2020/01/24	2020/01/24	rogid:2N9em5F7NIs4PJ/fM1bRvII7i6k9606	rogid:+aoVGSDXbzrq71ZKogtE9LHtHss9606	rigid:W0ISQORXAfABR+jH5IfpVHho8/Y	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q04656	uniprotkb:P28300	intact:EBI-7706409|ensembl:ENSP00000345728|intact:MINT-106053|uniprotkb:B1AT72|uniprotkb:Q9BYY8|uniprotkb:O00745|uniprotkb:O00227	intact:EBI-3893481|uniprotkb:B2R5Q3|uniprotkb:Q5FWF0|ensembl:ENSP00000231004	psi-mi:atp7a_human(display_long)|uniprotkb:ATP7A(gene name)|psi-mi:ATP7A(display_short)|uniprotkb:MC1(gene name synonym)|uniprotkb:MNK(gene name synonym)|uniprotkb:Copper pump 1(gene name synonym)|uniprotkb:Menkes disease-associated protein(gene name synonym)	psi-mi:lyox_human(display_long)|uniprotkb:LOX(gene name)|psi-mi:LOX(display_short)|uniprotkb:Lysyl oxidase(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Blockhuys et al. (2020)	pubmed:31932435|imex:IM-27669	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-25406866|imex:IM-27669-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000165240(gene)|ensembl:ENST00000341514(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001889"(liver development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0005375"(copper ion transmembrane transporter activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006568"(tryptophan metabolic process)|go:"GO:0006584"(catecholamine metabolic process)|go:"GO:0006825"(copper ion transport)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0007626"(locomotory behavior)|go:"GO:0010041"("response to iron(III) ion")|go:"GO:0010042"(response to manganese ion)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015677"(copper ion import)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016532"(superoxide dismutase copper chaperone activity)|go:"GO:0018205"(peptidyl-lysine modification)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0021860"(pyramidal neuron development)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031526"(brush border membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032767"(copper-dependent protein binding)|go:"GO:0032773"(positive regulation of tyrosinase activity)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|go:"GO:0033162"(melanosome membrane)|go:"GO:0034760"(negative regulation of iron ion transmembrane transport)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042093"(T-helper cell differentiation)|go:"GO:0042414"(epinephrine metabolic process)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043204"(perikaryon)|go:"GO:0043473"(pigmentation)|go:"GO:0043588"(skin development)|go:"GO:0043682"(P-type divalent copper transporter activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051087"(chaperone binding)|go:"GO:0051216"(cartilage development)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051542"(elastin biosynthetic process)|go:"GO:0060003"(copper ion export)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071279"(cellular response to cobalt ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071281"(cellular response to iron ion)|go:"GO:0071284"(cellular response to lead ion)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0140581"(P-type monovalent copper transporter activity)|go:"GO:1903036"(positive regulation of response to wounding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1904959"(regulation of cytochrome-c oxidase activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006121(Heavy metal transport/detoxification protein)|interpro:IPR006122(Copper ion-binding)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR017969|interpro:IPR018303|rcsb pdb:1S6U|rcsb pdb:1Y3J|interpro:IPR023298|interpro:IPR023299|interpro:IPR027256|rcsb pdb:1Y3K|interpro:IPR036163|rcsb pdb:1YJR|rcsb pdb:1YJT|rcsb pdb:1YJU|rcsb pdb:1YJV|rcsb pdb:2AW0|rcsb pdb:2G9O|rcsb pdb:2GA7|interpro:IPR036412|interpro:IPR044492|rcsb pdb:1AW0|rcsb pdb:1KVI|rcsb pdb:2K1R|rcsb pdb:2KIJ|rcsb pdb:2KMV|rcsb pdb:2KMX|rcsb pdb:3CJK|rcsb pdb:5T7L|reactome:R-HSA-3299685|reactome:R-HSA-6803544|reactome:R-HSA-936837|rcsb pdb:1KVJ|rcsb pdb:1Q8L|rcsb pdb:1S6O|refseq:NP_000043.4|refseq:NP_001269153.1	refseq:NP_002308.2|dip:DIP-49007N|ensembl:ENSG00000113083(gene)|ensembl:ENST00000231004(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004720"(protein-lysine 6-oxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0007507"(heart development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0018057"(peptidyl-lysine oxidation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030324"(lung development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035905"(ascending aorta development)|go:"GO:0035906"(descending aorta development)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0055001"(muscle cell development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061448"(connective tissue development)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:1900120"(regulation of receptor binding)|go:"GO:1903010"(regulation of bone development)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000586"(regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR001695(Lysyl oxidase)|interpro:IPR019828|mint:P28300|reactome:R-HSA-1566948|reactome:R-HSA-2243919|go:"GO:0046716"(muscle cell cellular homeostasis)	-	comment:mint|function:May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells|function:"Defects in ATP7A are the cause of Menkes syndrome (MD) [MIM:309400]; also known as kinky hair disease. MD is an X-linked recessive disease characterized by progressive neurodegeneration and connective-tissue disturbances: focal cerebral and cerebellar degeneration, early retardation in growth, peculiar hair, hypopigmentation, cutis laxa, vascular complications and death in early childhood. It is due to a defect in absorption and transport of copper"|function:"Defects in ATP7A are the cause of occipital horn syndrome (OHS) [MIM:304150]; also known as X-linked cutis laxa. Common features are unusual facial appearance, skeletal abnormalities, chronic diarrhea and genitourinary defects. The skeletal abnormalities included occipital horns, short, broad clavicles, deformed radii, ulnae and humeri, narrowing of the rib cage, undercalcified long bones with thin cortical walls and coxa valga"	-	figure legend:Figure 3A and 3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mda_mb_231)|taxid:9606(Homo sapiens Caucasian breast adenocarcinoma)	-	2020/01/24	2020/01/24	rogid:2N9em5F7NIs4PJ/fM1bRvII7i6k9606	rogid:bDUlKQ5akDOhya4GydJ+PaLs7Fo9606	rigid:32MaGg/gd2CWFmJqoQ/pGYDCk1c	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O00244	uniprotkb:P28300	intact:EBI-10179267|uniprotkb:Q2M1R6|uniprotkb:A8KAJ8|uniprotkb:D3DQI2|uniprotkb:Q56AP3|ensembl:ENSP00000316854|ensembl:ENSP00000429814|ensembl:ENSP00000430598	intact:EBI-3893481|uniprotkb:B2R5Q3|uniprotkb:Q5FWF0|ensembl:ENSP00000231004	psi-mi:atox1_human(display_long)|uniprotkb:ATOX1(gene name)|psi-mi:ATOX1(display_short)|uniprotkb:HAH1(gene name synonym)|uniprotkb:Metal transport protein ATX1(gene name synonym)	psi-mi:lyox_human(display_long)|uniprotkb:LOX(gene name)|psi-mi:LOX(display_short)|uniprotkb:Lysyl oxidase(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Blockhuys et al. (2020)	pubmed:31932435|imex:IM-27669	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-25406879|imex:IM-27669-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004036.1|ensembl:ENSG00000177556(gene)|ensembl:ENST00000313115(transcript)|ensembl:ENST00000522710(transcript)|ensembl:ENST00000524142(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0006825"(copper ion transport)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0016530"(metallochaperone activity)|go:"GO:0016531"(copper chaperone activity)|go:"GO:0032767"(copper-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051117"(ATPase binding)|go:"GO:0060003"(copper ion export)|go:"GO:1903136"(cuprous ion binding)|interpro:IPR006121(Heavy metal transport/detoxification protein)|interpro:IPR017969|interpro:IPR036163|rcsb pdb:1FE0|rcsb pdb:1FE4|rcsb pdb:1FEE|rcsb pdb:1TL4|rcsb pdb:1TL5|rcsb pdb:2K1R|rcsb pdb:2LQ9|rcsb pdb:3CJK|rcsb pdb:3IWL|rcsb pdb:3IWX|rcsb pdb:4QOT|rcsb pdb:4YDX|rcsb pdb:4YEA|rcsb pdb:5F0W|rcsb pdb:5T7L|reactome:R-HSA-3299685|reactome:R-HSA-6803544	refseq:NP_002308.2|dip:DIP-49007N|ensembl:ENSG00000113083(gene)|ensembl:ENST00000231004(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004720"(protein-lysine 6-oxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0007507"(heart development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0018057"(peptidyl-lysine oxidation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030324"(lung development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035905"(ascending aorta development)|go:"GO:0035906"(descending aorta development)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0055001"(muscle cell development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061448"(connective tissue development)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:1900120"(regulation of receptor binding)|go:"GO:1903010"(regulation of bone development)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000586"(regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR001695(Lysyl oxidase)|interpro:IPR019828|mint:P28300|reactome:R-HSA-1566948|reactome:R-HSA-2243919|go:"GO:0046716"(muscle cell cellular homeostasis)	-	-	-	figure legend:Figure 3A and 3B|comment:"The presence of Atox1 appears necessary for ATP7A-LOXPP (prolysyloxidase) proximity"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mda_mb_231)|taxid:9606(Homo sapiens Caucasian breast adenocarcinoma)	-	2020/01/24	2020/01/24	rogid:+aoVGSDXbzrq71ZKogtE9LHtHss9606	rogid:bDUlKQ5akDOhya4GydJ+PaLs7Fo9606	rigid:o6Z6YTKGEM0J5S1O7Jg6pjJWwA0	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)