#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chebi:"CHEBI:29108"	uniprotkb:Q99653	intact:EBI-1169353	intact:EBI-722721|uniprotkb:Q6FHZ9|uniprotkb:B2R6H9|ensembl:ENSP00000335632	psi-mi:"calcium(2+)"(display_short)|psi-mi:"CHEBI:29108"(display_long)	psi-mi:chp1_human(display_long)|uniprotkb:CHP1(gene name)|psi-mi:CHP1(display_short)|uniprotkb:CHP(gene name synonym)|uniprotkb:Calcineurin B-like protein(gene name synonym)|uniprotkb:Calcium-binding protein CHP(gene name synonym)|uniprotkb:Calcium-binding protein p22(gene name synonym)|uniprotkb:EF-hand calcium-binding domain-containing protein p22(gene name synonym)	psi-mi:"MI:0051"(fluorescence technology)	Liang et al. (2020)	imex:IM-28248|pubmed:31912575	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25684432|imex:IM-28248-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_009167.1|ensembl:ENSG00000187446(gene)|ensembl:ENST00000334660(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006903"(vesicle targeting)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0010923"(negative regulation of phosphatase activity)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019900"(kinase binding)|go:"GO:0022406"(membrane docking)|go:"GO:0030133"(transport vesicle)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032417"("positive regulation of sodium:proton antiporter activity")|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0060050"(positive regulation of protein glycosylation)|go:"GO:0061024"(membrane organization)|go:"GO:0061025"(membrane fusion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071073"(positive regulation of phospholipid biosynthetic process)|go:"GO:0071468"(cellular response to acidic pH)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1901214"(regulation of neuron death)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|rcsb pdb:2E30|rcsb pdb:7DSV|rcsb pdb:7DSX|reactome:R-HSA-2160916	-	-	-	figure legend:Fig.2A, 2B, Supp. Fig. 3|inhibition:"EGTA (CHEBI:30740)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/06/25	2020/06/25	-	rogid:6/VeERuA4F0QeWlUj0pN8u0E6hc9606	-	false	-	sufficient binding region:2-195	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:29108"	uniprotkb:O43745	intact:EBI-1169353	intact:EBI-8525536|intact:MINT-2729920|uniprotkb:A8K2I8|ensembl:ENSP00000300113	psi-mi:"calcium(2+)"(display_short)|psi-mi:"CHEBI:29108"(display_long)	psi-mi:chp2_human(display_long)|uniprotkb:CHP2(gene name)|psi-mi:CHP2(display_short)|uniprotkb:HCA520(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated antigen 520(gene name synonym)	psi-mi:"MI:0051"(fluorescence technology)	Liang et al. (2020)	imex:IM-28248|pubmed:31912575	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25684439|imex:IM-28248-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_071380.1|ensembl:ENSG00000166869(gene)|ensembl:ENST00000300113(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0015031"(protein transport)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:O43745|rcsb pdb:2BEC	-	-	comment:mint|function:Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death	figure legend:Fig.2A, 2B, Supp. Fig. 3|inhibition:"EGTA (CHEBI:30740)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/06/25	2020/06/25	-	rogid:UOhi/gx3k4psrhdl7xbrX/+A8Uo9606	-	false	-	sufficient binding region:2-196	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:29108"	uniprotkb:Q96BS2	intact:EBI-1169353	intact:EBI-740653|ensembl:ENSP00000334785|uniprotkb:Q9NWT9|uniprotkb:F5H1Y5	psi-mi:"calcium(2+)"(display_short)|psi-mi:"CHEBI:29108"(display_long)	psi-mi:chp3_human(display_long)|uniprotkb:TESC(gene name)|psi-mi:TESC(display_short)|uniprotkb:CHP3(gene name synonym)|uniprotkb:Tescalcin(gene name synonym)	psi-mi:"MI:0051"(fluorescence technology)	Liang et al. (2020)	imex:IM-28248|pubmed:31912575	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25684443|imex:IM-28248-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_060369.3|ensembl:ENSG00000088992(gene)|ensembl:ENST00000335209(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001726"(ruffle)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015031"(protein transport)|go:"GO:0019212"(phosphatase inhibitor activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0032417"("positive regulation of sodium:proton antiporter activity")|go:"GO:0032587"(ruffle membrane)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045654"(positive regulation of megakaryocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050821"(protein stabilization)|go:"GO:0051604"(protein maturation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|refseq:NP_001161797.1|refseq:XP_016875022.1	-	-	-	figure legend:Fig.2A, 2B, Supp. Fig. 3|inhibition:"EGTA (CHEBI:30740)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/06/25	2020/06/25	-	rogid:jGQRRQPEW0Z9Q/EDsPiSnEej/Uk9606	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:29108"	uniprotkb:P0DP23	intact:EBI-1169353	intact:EBI-25817233|ensembl:ENSP00000349467|intact:EBI-28973196|uniprotkb:P02593|uniprotkb:P62158|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q13942|uniprotkb:Q53S29|uniprotkb:Q61379|uniprotkb:Q61380|uniprotkb:Q96HK3	psi-mi:"calcium(2+)"(display_short)|psi-mi:"CHEBI:29108"(display_long)	psi-mi:calm1_human(display_long)|uniprotkb:CALM1(gene name)|psi-mi:CALM1(display_short)|uniprotkb:CALM(gene name synonym)|uniprotkb:CAM(gene name synonym)|uniprotkb:CAM1(gene name synonym)	psi-mi:"MI:0051"(fluorescence technology)	Liang et al. (2020)	imex:IM-28248|pubmed:31912575	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25684473|imex:IM-28248-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	rcsb pdb:2I08|rcsb pdb:2JZI|rcsb pdb:2K0E|rcsb pdb:2K0F|rcsb pdb:2K0J|rcsb pdb:2K61|rcsb pdb:2KNE|rcsb pdb:2KUG|rcsb pdb:2KUH|rcsb pdb:2L53|rcsb pdb:2L7L|rcsb pdb:2LGF|rcsb pdb:2LL6|rcsb pdb:2LL7|rcsb pdb:2LQC|rcsb pdb:2LQP|rcsb pdb:2LV6|rcsb pdb:2M0J|rcsb pdb:2M0K|rcsb pdb:2M55|rcsb pdb:2MG5|rcsb pdb:2N27|rcsb pdb:2N6A|rcsb pdb:2N77|rcsb pdb:2N8J|rcsb pdb:2R28|rcsb pdb:2V01|rcsb pdb:2V02|rcsb pdb:2VAY|rcsb pdb:2HF5|rcsb pdb:2W73|rcsb pdb:2WEL|rcsb pdb:2X0G|go:"GO:0098901"(regulation of cardiac muscle cell action potential)|go:"GO:0140056"(organelle localization by membrane tethering)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1901842"(negative regulation of high voltage-gated calcium channel activity)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|go:"GO:1902494"(catalytic complex)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|go:"GO:1990456"(mitochondrion-endoplasmic reticulum membrane tethering)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:P0DP23|rcsb pdb:1AJI|rcsb pdb:1CDL|rcsb pdb:1CLL|rcsb pdb:1CTR|rcsb pdb:1IWQ|rcsb pdb:1J7O|rcsb pdb:1J7P|rcsb pdb:1K90|go:"GO:0097718"(disordered domain specific binding)|rcsb pdb:1K93|rcsb pdb:1L7Z|rcsb pdb:1LVC|ensembl:ENSG00000198668(gene)|ensembl:ENST00000356978(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0001975"(response to amphetamine)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030017"(sarcomere)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031432"(titin binding)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0031982"(vesicle)|go:"GO:0031997"(N-terminal myristoylation domain binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0043209"(myelin sheath)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:0090151"(establishment of protein localization to mitochondrial membrane)|go:"GO:0030672"(synaptic vesicle membrane)|rcsb pdb:1PK0|rcsb pdb:1S26|rcsb pdb:1SK6|rcsb pdb:1SW8|rcsb pdb:1UP5|rcsb pdb:1WRZ|rcsb pdb:1XFU|rcsb pdb:1XFV|rcsb pdb:1XFW|rcsb pdb:1XFX|rcsb pdb:1XFY|rcsb pdb:1XFZ|rcsb pdb:1Y6W|rcsb pdb:1YR5|rcsb pdb:1YRT|rcsb pdb:1YRU|rcsb pdb:1ZOT|rcsb pdb:1ZUZ|rcsb pdb:2BE6|rcsb pdb:1NKF|rcsb pdb:2F3Y|rcsb pdb:2F3Z|rcsb pdb:2Y4V|rcsb pdb:3DVE|rcsb pdb:3DVJ|rcsb pdb:3DVK|rcsb pdb:3DVM|rcsb pdb:3EWT|rcsb pdb:3EWV|rcsb pdb:3G43|rcsb pdb:3HR4|rcsb pdb:3J41|rcsb pdb:3O77|rcsb pdb:3O78|rcsb pdb:3OXQ|rcsb pdb:3SUI|rcsb pdb:3UCT|rcsb pdb:3UCW|rcsb pdb:3UCY|rcsb pdb:4BW7|rcsb pdb:4BW8|rcsb pdb:4BYF|rcsb pdb:4DCK|rcsb pdb:4DJC|rcsb pdb:4GOW|rcsb pdb:4JPZ|rcsb pdb:4JQ0|rcsb pdb:4L79|rcsb pdb:4LZX|rcsb pdb:4M1L|rcsb pdb:4OVN|rcsb pdb:4Q57|rcsb pdb:4Q5U|rcsb pdb:4UMO|rcsb pdb:4UPU|rcsb pdb:4V0C|rcsb pdb:5COC|rcsb pdb:3BYA|rcsb pdb:5DBR|rcsb pdb:5DOW|rcsb pdb:5DSU|rcsb pdb:5GGM|rcsb pdb:5I0I|rcsb pdb:5J03|rcsb pdb:5J8H|rcsb pdb:5JQA|rcsb pdb:5JTH|rcsb pdb:5K7L|rcsb pdb:5K8Q|rcsb pdb:5OEO|rcsb pdb:5TP5|rcsb pdb:5TP6|rcsb pdb:5V02|rcsb pdb:5V03|rcsb pdb:5V7X|rcsb pdb:5WBX|rcsb pdb:5WC5|rcsb pdb:6B8L|rcsb pdb:6B8M|rcsb pdb:6B8N|rcsb pdb:6B8P|rcsb pdb:6B8Q|rcsb pdb:6BUT|rcsb pdb:6C1D|rcsb pdb:6C1G|rcsb pdb:6C1H|rcsb pdb:6CNM|rcsb pdb:6CNN|rcsb pdb:6CNO|rcsb pdb:6DAD|rcsb pdb:6DAE|rcsb pdb:6DAF|rcsb pdb:6DAH|rcsb pdb:6E2F|rcsb pdb:6E2G|rcsb pdb:6EEB|rcsb pdb:6FEG|rcsb pdb:6FEH|rcsb pdb:6GDK|rcsb pdb:6GDL|rcsb pdb:6HCS|rcsb pdb:6HR1|rcsb pdb:6JI8|rcsb pdb:6JII|rcsb pdb:6JIU|rcsb pdb:6JIY|rcsb pdb:6JRS|rcsb pdb:6JV2|rcsb pdb:6K4K|rcsb pdb:6K4L|rcsb pdb:6K4R|rcsb pdb:6M2W|rcsb pdb:6M7H|rcsb pdb:6MUD|rcsb pdb:6MUE|rcsb pdb:6N5W|rcsb pdb:6O5G|rcsb pdb:6OS4|rcsb pdb:6PAW|rcsb pdb:6PBX|rcsb pdb:6PBY|rcsb pdb:6U39|rcsb pdb:6U3A|rcsb pdb:6U3B|rcsb pdb:6U3D|rcsb pdb:6UZZ|rcsb pdb:6V00|rcsb pdb:6V01|rcsb pdb:6X32|rcsb pdb:6X33|rcsb pdb:6X35|rcsb pdb:6X36|rcsb pdb:6XXX|rcsb pdb:6XY3|rcsb pdb:6XYR|rcsb pdb:6Y4P|rcsb pdb:6Y94|rcsb pdb:6Y95|rcsb pdb:6YNS|rcsb pdb:6YNU|rcsb pdb:6ZBI|rcsb pdb:7KL5|reactome:R-HSA-111932|reactome:R-HSA-111933|reactome:R-HSA-111957|reactome:R-HSA-111997|reactome:R-HSA-114608|reactome:R-HSA-1445148|reactome:R-HSA-442982|reactome:R-HSA-445355|reactome:R-HSA-451308|reactome:R-HSA-1474151|reactome:R-HSA-5210891|reactome:R-HSA-5218920|reactome:R-HSA-5218921|reactome:R-HSA-163615|reactome:R-HSA-180024|reactome:R-HSA-5576892|reactome:R-HSA-1855204|reactome:R-HSA-2025928|reactome:R-HSA-5578775|reactome:R-HSA-5607763|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-203615|reactome:R-HSA-2151201|reactome:R-HSA-2514859|reactome:R-HSA-5673000|reactome:R-HSA-2672351|reactome:R-HSA-5673001|reactome:R-HSA-6802946|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-2871809|reactome:R-HSA-4086398|reactome:R-HSA-70221|reactome:R-HSA-8876725|reactome:R-HSA-9009391|reactome:R-HSA-418359|reactome:R-HSA-425561|reactome:R-HSA-438066|reactome:R-HSA-442720|reactome:R-HSA-9022535|reactome:R-HSA-9022692|reactome:R-HSA-936837|reactome:R-HSA-9617324|reactome:R-HSA-9619229|reactome:R-HSA-9619483|reactome:R-HSA-9620244|reactome:R-HSA-9648002|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664323|reactome:R-HSA-983695|reactome:R-HSA-442729|refseq:NP_001316851.1|refseq:NP_001734.1|refseq:NP_005175.2|refseq:NP_008819.1	-	-	-	figure legend:Fig.2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/06/25	2020/10/22	-	rogid:tTYcOd9bOh211njZVz7cYVybAMQ9606	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P19634	uniprotkb:Q99653	intact:EBI-743635|uniprotkb:Q96EM2|ensembl:ENSP00000263980|uniprotkb:B1ALD6|uniprotkb:D3DPL4	intact:EBI-722721|uniprotkb:Q6FHZ9|uniprotkb:B2R6H9|ensembl:ENSP00000335632	psi-mi:sl9a1_human(display_long)|uniprotkb:"Na(+)/H(+) exchanger 1"(gene name synonym)|uniprotkb:Solute carrier family 9 member 1(gene name synonym)|uniprotkb:"Na(+)/H(+) antiporter, amiloride-sensitive"(gene name synonym)|uniprotkb:APNH(gene name synonym)|uniprotkb:SLC9A1(gene name)|psi-mi:SLC9A1(display_short)|uniprotkb:APNH1(gene name synonym)|uniprotkb:NHE1(gene name synonym)	psi-mi:chp1_human(display_long)|uniprotkb:CHP1(gene name)|psi-mi:CHP1(display_short)|uniprotkb:CHP(gene name synonym)|uniprotkb:Calcineurin B-like protein(gene name synonym)|uniprotkb:Calcium-binding protein CHP(gene name synonym)|uniprotkb:Calcium-binding protein p22(gene name synonym)|uniprotkb:EF-hand calcium-binding domain-containing protein p22(gene name synonym)	psi-mi:"MI:0051"(fluorescence technology)	Liang et al. (2020)	imex:IM-28248|pubmed:31912575	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25684520|imex:IM-28248-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003038.2|go:"GO:0009986"(cell surface)|ensembl:ENSG00000090020(gene)|ensembl:ENST00000263980(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0015299"("solute:proton antiporter activity")|go:"GO:0015385"("sodium:proton antiporter activity")|go:"GO:0015386"("potassium:proton antiporter activity")|go:"GO:0006811"(ion transport)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0006885"(regulation of pH)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030315"(T-tubule)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0016021"(integral component of membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070417"(cellular response to cold)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0070997"(neuron death)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071468"(cellular response to acidic pH)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086040"("sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential")|go:"GO:0086092"(regulation of the force of heart contraction by cardiac conduction)|go:"GO:0090533"(cation-transporting ATPase complex)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:1902600"(proton transmembrane transport)|go:"GO:1903281"("positive regulation of calcium:sodium antiporter activity")|interpro:IPR001970("Na+/H+ exchanger isoform 1 (NHE1)")|interpro:IPR004709(Sodium/hydrogen exchanger subfamily)|interpro:IPR006153(Sodium/hydrogen exchanger)|interpro:IPR018422|interpro:IPR032103|mint:P19634|rcsb pdb:1Y4E|rcsb pdb:2BEC|rcsb pdb:2E30|rcsb pdb:2HTG|rcsb pdb:2KBV|rcsb pdb:2L0E|rcsb pdb:2MDF|rcsb pdb:2YGG|rcsb pdb:6BJF|rcsb pdb:6NUC|rcsb pdb:6NUF|rcsb pdb:6NUU|rcsb pdb:6ZBI|rcsb pdb:7DSV|rcsb pdb:7DSW|rcsb pdb:7DSX|reactome:R-HSA-2160916|reactome:R-HSA-425986	refseq:NP_009167.1|ensembl:ENSG00000187446(gene)|ensembl:ENST00000334660(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006903"(vesicle targeting)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0010923"(negative regulation of phosphatase activity)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019900"(kinase binding)|go:"GO:0022406"(membrane docking)|go:"GO:0030133"(transport vesicle)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032417"("positive regulation of sodium:proton antiporter activity")|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0060050"(positive regulation of protein glycosylation)|go:"GO:0061024"(membrane organization)|go:"GO:0061025"(membrane fusion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071073"(positive regulation of phospholipid biosynthetic process)|go:"GO:0071468"(cellular response to acidic pH)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1901214"(regulation of neuron death)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|rcsb pdb:2E30|rcsb pdb:7DSV|rcsb pdb:7DSX|reactome:R-HSA-2160916	-	-	-	figure legend:Fig.3, Supp. Fig. 2|comment:Binding is calcium-independent|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/06/25	2020/06/25	rogid:wU1AHJ9CJrDPjiRZk2PhcO1OfDc9606	rogid:6/VeERuA4F0QeWlUj0pN8u0E6hc9606	rigid:iVmfTnwCHzP6oag9fpGpc+0qrLs	false	his tag:c-c|sufficient binding region:503-545|maltose binding protein tag:n-n	sufficient binding region:2-195	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43745	uniprotkb:P19634	intact:EBI-8525536|intact:MINT-2729920|uniprotkb:A8K2I8|ensembl:ENSP00000300113	intact:EBI-743635|uniprotkb:Q96EM2|ensembl:ENSP00000263980|uniprotkb:B1ALD6|uniprotkb:D3DPL4	psi-mi:chp2_human(display_long)|uniprotkb:CHP2(gene name)|psi-mi:CHP2(display_short)|uniprotkb:HCA520(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated antigen 520(gene name synonym)	psi-mi:sl9a1_human(display_long)|uniprotkb:"Na(+)/H(+) exchanger 1"(gene name synonym)|uniprotkb:Solute carrier family 9 member 1(gene name synonym)|uniprotkb:"Na(+)/H(+) antiporter, amiloride-sensitive"(gene name synonym)|uniprotkb:APNH(gene name synonym)|uniprotkb:SLC9A1(gene name)|psi-mi:SLC9A1(display_short)|uniprotkb:APNH1(gene name synonym)|uniprotkb:NHE1(gene name synonym)	psi-mi:"MI:0051"(fluorescence technology)	Liang et al. (2020)	imex:IM-28248|pubmed:31912575	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25684529|imex:IM-28248-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071380.1|ensembl:ENSG00000166869(gene)|ensembl:ENST00000300113(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0015031"(protein transport)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:O43745|rcsb pdb:2BEC	refseq:NP_003038.2|go:"GO:0009986"(cell surface)|ensembl:ENSG00000090020(gene)|ensembl:ENST00000263980(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0015299"("solute:proton antiporter activity")|go:"GO:0015385"("sodium:proton antiporter activity")|go:"GO:0015386"("potassium:proton antiporter activity")|go:"GO:0006811"(ion transport)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0006885"(regulation of pH)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030315"(T-tubule)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0016021"(integral component of membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070417"(cellular response to cold)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0070997"(neuron death)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071468"(cellular response to acidic pH)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086040"("sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential")|go:"GO:0086092"(regulation of the force of heart contraction by cardiac conduction)|go:"GO:0090533"(cation-transporting ATPase complex)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:1902600"(proton transmembrane transport)|go:"GO:1903281"("positive regulation of calcium:sodium antiporter activity")|interpro:IPR001970("Na+/H+ exchanger isoform 1 (NHE1)")|interpro:IPR004709(Sodium/hydrogen exchanger subfamily)|interpro:IPR006153(Sodium/hydrogen exchanger)|interpro:IPR018422|interpro:IPR032103|mint:P19634|rcsb pdb:1Y4E|rcsb pdb:2BEC|rcsb pdb:2E30|rcsb pdb:2HTG|rcsb pdb:2KBV|rcsb pdb:2L0E|rcsb pdb:2MDF|rcsb pdb:2YGG|rcsb pdb:6BJF|rcsb pdb:6NUC|rcsb pdb:6NUF|rcsb pdb:6NUU|rcsb pdb:6ZBI|rcsb pdb:7DSV|rcsb pdb:7DSW|rcsb pdb:7DSX|reactome:R-HSA-2160916|reactome:R-HSA-425986	-	comment:mint|function:Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death	-	figure legend:Fig.3, Supp. Fig. 2|comment:Binding is calcium-independent|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/06/25	2020/06/25	rogid:UOhi/gx3k4psrhdl7xbrX/+A8Uo9606	rogid:wU1AHJ9CJrDPjiRZk2PhcO1OfDc9606	rigid:xri+F8B5r4C26YtkVcrjBZFKWag	false	sufficient binding region:2-196	his tag:c-c|sufficient binding region:503-545|maltose binding protein tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P19634	uniprotkb:Q96BS2	intact:EBI-743635|uniprotkb:Q96EM2|ensembl:ENSP00000263980|uniprotkb:B1ALD6|uniprotkb:D3DPL4	intact:EBI-740653|ensembl:ENSP00000334785|uniprotkb:Q9NWT9|uniprotkb:F5H1Y5	psi-mi:sl9a1_human(display_long)|uniprotkb:"Na(+)/H(+) exchanger 1"(gene name synonym)|uniprotkb:Solute carrier family 9 member 1(gene name synonym)|uniprotkb:"Na(+)/H(+) antiporter, amiloride-sensitive"(gene name synonym)|uniprotkb:APNH(gene name synonym)|uniprotkb:SLC9A1(gene name)|psi-mi:SLC9A1(display_short)|uniprotkb:APNH1(gene name synonym)|uniprotkb:NHE1(gene name synonym)	psi-mi:chp3_human(display_long)|uniprotkb:TESC(gene name)|psi-mi:TESC(display_short)|uniprotkb:CHP3(gene name synonym)|uniprotkb:Tescalcin(gene name synonym)	psi-mi:"MI:0051"(fluorescence technology)	Liang et al. (2020)	imex:IM-28248|pubmed:31912575	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25684537|imex:IM-28248-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003038.2|go:"GO:0009986"(cell surface)|ensembl:ENSG00000090020(gene)|ensembl:ENST00000263980(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0015299"("solute:proton antiporter activity")|go:"GO:0015385"("sodium:proton antiporter activity")|go:"GO:0015386"("potassium:proton antiporter activity")|go:"GO:0006811"(ion transport)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0006885"(regulation of pH)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030315"(T-tubule)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0016021"(integral component of membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070417"(cellular response to cold)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0070997"(neuron death)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071468"(cellular response to acidic pH)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086040"("sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential")|go:"GO:0086092"(regulation of the force of heart contraction by cardiac conduction)|go:"GO:0090533"(cation-transporting ATPase complex)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:1902600"(proton transmembrane transport)|go:"GO:1903281"("positive regulation of calcium:sodium antiporter activity")|interpro:IPR001970("Na+/H+ exchanger isoform 1 (NHE1)")|interpro:IPR004709(Sodium/hydrogen exchanger subfamily)|interpro:IPR006153(Sodium/hydrogen exchanger)|interpro:IPR018422|interpro:IPR032103|mint:P19634|rcsb pdb:1Y4E|rcsb pdb:2BEC|rcsb pdb:2E30|rcsb pdb:2HTG|rcsb pdb:2KBV|rcsb pdb:2L0E|rcsb pdb:2MDF|rcsb pdb:2YGG|rcsb pdb:6BJF|rcsb pdb:6NUC|rcsb pdb:6NUF|rcsb pdb:6NUU|rcsb pdb:6ZBI|rcsb pdb:7DSV|rcsb pdb:7DSW|rcsb pdb:7DSX|reactome:R-HSA-2160916|reactome:R-HSA-425986	refseq:NP_060369.3|ensembl:ENSG00000088992(gene)|ensembl:ENST00000335209(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001726"(ruffle)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015031"(protein transport)|go:"GO:0019212"(phosphatase inhibitor activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0032417"("positive regulation of sodium:proton antiporter activity")|go:"GO:0032587"(ruffle membrane)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045654"(positive regulation of megakaryocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050821"(protein stabilization)|go:"GO:0051604"(protein maturation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|refseq:NP_001161797.1|refseq:XP_016875022.1	-	-	-	figure legend:Fig.3, Supp. Fig. 2|comment:Binding is calcium-independent|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/06/25	2020/06/25	rogid:wU1AHJ9CJrDPjiRZk2PhcO1OfDc9606	rogid:jGQRRQPEW0Z9Q/EDsPiSnEej/Uk9606	rigid:fa4MD3LE4JjqCnjLZCnaEbdlpJg	false	his tag:c-c|sufficient binding region:503-545|maltose binding protein tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P19634	uniprotkb:Q99653	intact:EBI-743635|uniprotkb:Q96EM2|ensembl:ENSP00000263980|uniprotkb:B1ALD6|uniprotkb:D3DPL4	intact:EBI-722721|uniprotkb:Q6FHZ9|uniprotkb:B2R6H9|ensembl:ENSP00000335632	psi-mi:sl9a1_human(display_long)|uniprotkb:"Na(+)/H(+) exchanger 1"(gene name synonym)|uniprotkb:Solute carrier family 9 member 1(gene name synonym)|uniprotkb:"Na(+)/H(+) antiporter, amiloride-sensitive"(gene name synonym)|uniprotkb:APNH(gene name synonym)|uniprotkb:SLC9A1(gene name)|psi-mi:SLC9A1(display_short)|uniprotkb:APNH1(gene name synonym)|uniprotkb:NHE1(gene name synonym)	psi-mi:chp1_human(display_long)|uniprotkb:CHP1(gene name)|psi-mi:CHP1(display_short)|uniprotkb:CHP(gene name synonym)|uniprotkb:Calcineurin B-like protein(gene name synonym)|uniprotkb:Calcium-binding protein CHP(gene name synonym)|uniprotkb:Calcium-binding protein p22(gene name synonym)|uniprotkb:EF-hand calcium-binding domain-containing protein p22(gene name synonym)	psi-mi:"MI:1247"(microscale thermophoresis)	Liang et al. (2020)	imex:IM-28248|pubmed:31912575	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25684564|imex:IM-28248-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003038.2|go:"GO:0009986"(cell surface)|ensembl:ENSG00000090020(gene)|ensembl:ENST00000263980(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0015299"("solute:proton antiporter activity")|go:"GO:0015385"("sodium:proton antiporter activity")|go:"GO:0015386"("potassium:proton antiporter activity")|go:"GO:0006811"(ion transport)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0006885"(regulation of pH)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030315"(T-tubule)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0016021"(integral component of membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070417"(cellular response to cold)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0070997"(neuron death)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071468"(cellular response to acidic pH)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086040"("sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential")|go:"GO:0086092"(regulation of the force of heart contraction by cardiac conduction)|go:"GO:0090533"(cation-transporting ATPase complex)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:1902600"(proton transmembrane transport)|go:"GO:1903281"("positive regulation of calcium:sodium antiporter activity")|interpro:IPR001970("Na+/H+ exchanger isoform 1 (NHE1)")|interpro:IPR004709(Sodium/hydrogen exchanger subfamily)|interpro:IPR006153(Sodium/hydrogen exchanger)|interpro:IPR018422|interpro:IPR032103|mint:P19634|rcsb pdb:1Y4E|rcsb pdb:2BEC|rcsb pdb:2E30|rcsb pdb:2HTG|rcsb pdb:2KBV|rcsb pdb:2L0E|rcsb pdb:2MDF|rcsb pdb:2YGG|rcsb pdb:6BJF|rcsb pdb:6NUC|rcsb pdb:6NUF|rcsb pdb:6NUU|rcsb pdb:6ZBI|rcsb pdb:7DSV|rcsb pdb:7DSW|rcsb pdb:7DSX|reactome:R-HSA-2160916|reactome:R-HSA-425986	refseq:NP_009167.1|ensembl:ENSG00000187446(gene)|ensembl:ENST00000334660(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006903"(vesicle targeting)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0010923"(negative regulation of phosphatase activity)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019900"(kinase binding)|go:"GO:0022406"(membrane docking)|go:"GO:0030133"(transport vesicle)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032417"("positive regulation of sodium:proton antiporter activity")|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0060050"(positive regulation of protein glycosylation)|go:"GO:0061024"(membrane organization)|go:"GO:0061025"(membrane fusion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071073"(positive regulation of phospholipid biosynthetic process)|go:"GO:0071468"(cellular response to acidic pH)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1901214"(regulation of neuron death)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|rcsb pdb:2E30|rcsb pdb:7DSV|rcsb pdb:7DSX|reactome:R-HSA-2160916	-	-	-	figure legend:Fig.4A, 4B, Supp. Fig. 5, Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:5.95x10^-8(molar)	2020/06/25	2020/06/25	rogid:wU1AHJ9CJrDPjiRZk2PhcO1OfDc9606	rogid:6/VeERuA4F0QeWlUj0pN8u0E6hc9606	rigid:iVmfTnwCHzP6oag9fpGpc+0qrLs	false	his tag:c-c|sufficient binding region:503-545|maltose binding protein tag:n-n	sufficient binding region:2-195	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43745	uniprotkb:P19634	intact:EBI-8525536|intact:MINT-2729920|uniprotkb:A8K2I8|ensembl:ENSP00000300113	intact:EBI-743635|uniprotkb:Q96EM2|ensembl:ENSP00000263980|uniprotkb:B1ALD6|uniprotkb:D3DPL4	psi-mi:chp2_human(display_long)|uniprotkb:CHP2(gene name)|psi-mi:CHP2(display_short)|uniprotkb:HCA520(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated antigen 520(gene name synonym)	psi-mi:sl9a1_human(display_long)|uniprotkb:"Na(+)/H(+) exchanger 1"(gene name synonym)|uniprotkb:Solute carrier family 9 member 1(gene name synonym)|uniprotkb:"Na(+)/H(+) antiporter, amiloride-sensitive"(gene name synonym)|uniprotkb:APNH(gene name synonym)|uniprotkb:SLC9A1(gene name)|psi-mi:SLC9A1(display_short)|uniprotkb:APNH1(gene name synonym)|uniprotkb:NHE1(gene name synonym)	psi-mi:"MI:1247"(microscale thermophoresis)	Liang et al. (2020)	imex:IM-28248|pubmed:31912575	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25684576|imex:IM-28248-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071380.1|ensembl:ENSG00000166869(gene)|ensembl:ENST00000300113(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0015031"(protein transport)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:O43745|rcsb pdb:2BEC	refseq:NP_003038.2|go:"GO:0009986"(cell surface)|ensembl:ENSG00000090020(gene)|ensembl:ENST00000263980(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0015299"("solute:proton antiporter activity")|go:"GO:0015385"("sodium:proton antiporter activity")|go:"GO:0015386"("potassium:proton antiporter activity")|go:"GO:0006811"(ion transport)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0006885"(regulation of pH)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030315"(T-tubule)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0016021"(integral component of membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070417"(cellular response to cold)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0070997"(neuron death)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071468"(cellular response to acidic pH)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086040"("sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential")|go:"GO:0086092"(regulation of the force of heart contraction by cardiac conduction)|go:"GO:0090533"(cation-transporting ATPase complex)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:1902600"(proton transmembrane transport)|go:"GO:1903281"("positive regulation of calcium:sodium antiporter activity")|interpro:IPR001970("Na+/H+ exchanger isoform 1 (NHE1)")|interpro:IPR004709(Sodium/hydrogen exchanger subfamily)|interpro:IPR006153(Sodium/hydrogen exchanger)|interpro:IPR018422|interpro:IPR032103|mint:P19634|rcsb pdb:1Y4E|rcsb pdb:2BEC|rcsb pdb:2E30|rcsb pdb:2HTG|rcsb pdb:2KBV|rcsb pdb:2L0E|rcsb pdb:2MDF|rcsb pdb:2YGG|rcsb pdb:6BJF|rcsb pdb:6NUC|rcsb pdb:6NUF|rcsb pdb:6NUU|rcsb pdb:6ZBI|rcsb pdb:7DSV|rcsb pdb:7DSW|rcsb pdb:7DSX|reactome:R-HSA-2160916|reactome:R-HSA-425986	-	comment:mint|function:Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death	-	figure legend:Fig.4C, 4D, Supp. Fig. 5, Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:3.3x10^-9(molar)	2020/06/25	2020/06/25	rogid:UOhi/gx3k4psrhdl7xbrX/+A8Uo9606	rogid:wU1AHJ9CJrDPjiRZk2PhcO1OfDc9606	rigid:xri+F8B5r4C26YtkVcrjBZFKWag	false	sufficient binding region:2-196	his tag:c-c|sufficient binding region:503-545|maltose binding protein tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P19634	uniprotkb:Q99653	intact:EBI-743635|uniprotkb:Q96EM2|ensembl:ENSP00000263980|uniprotkb:B1ALD6|uniprotkb:D3DPL4	intact:EBI-722721|uniprotkb:Q6FHZ9|uniprotkb:B2R6H9|ensembl:ENSP00000335632	psi-mi:sl9a1_human(display_long)|uniprotkb:"Na(+)/H(+) exchanger 1"(gene name synonym)|uniprotkb:Solute carrier family 9 member 1(gene name synonym)|uniprotkb:"Na(+)/H(+) antiporter, amiloride-sensitive"(gene name synonym)|uniprotkb:APNH(gene name synonym)|uniprotkb:SLC9A1(gene name)|psi-mi:SLC9A1(display_short)|uniprotkb:APNH1(gene name synonym)|uniprotkb:NHE1(gene name synonym)	psi-mi:chp1_human(display_long)|uniprotkb:CHP1(gene name)|psi-mi:CHP1(display_short)|uniprotkb:CHP(gene name synonym)|uniprotkb:Calcineurin B-like protein(gene name synonym)|uniprotkb:Calcium-binding protein CHP(gene name synonym)|uniprotkb:Calcium-binding protein p22(gene name synonym)|uniprotkb:EF-hand calcium-binding domain-containing protein p22(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Liang et al. (2020)	imex:IM-28248|pubmed:31912575	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25684595|imex:IM-28248-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003038.2|go:"GO:0009986"(cell surface)|ensembl:ENSG00000090020(gene)|ensembl:ENST00000263980(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0015299"("solute:proton antiporter activity")|go:"GO:0015385"("sodium:proton antiporter activity")|go:"GO:0015386"("potassium:proton antiporter activity")|go:"GO:0006811"(ion transport)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0006885"(regulation of pH)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030315"(T-tubule)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0016021"(integral component of membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070417"(cellular response to cold)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0070997"(neuron death)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071468"(cellular response to acidic pH)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086040"("sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential")|go:"GO:0086092"(regulation of the force of heart contraction by cardiac conduction)|go:"GO:0090533"(cation-transporting ATPase complex)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:1902600"(proton transmembrane transport)|go:"GO:1903281"("positive regulation of calcium:sodium antiporter activity")|interpro:IPR001970("Na+/H+ exchanger isoform 1 (NHE1)")|interpro:IPR004709(Sodium/hydrogen exchanger subfamily)|interpro:IPR006153(Sodium/hydrogen exchanger)|interpro:IPR018422|interpro:IPR032103|mint:P19634|rcsb pdb:1Y4E|rcsb pdb:2BEC|rcsb pdb:2E30|rcsb pdb:2HTG|rcsb pdb:2KBV|rcsb pdb:2L0E|rcsb pdb:2MDF|rcsb pdb:2YGG|rcsb pdb:6BJF|rcsb pdb:6NUC|rcsb pdb:6NUF|rcsb pdb:6NUU|rcsb pdb:6ZBI|rcsb pdb:7DSV|rcsb pdb:7DSW|rcsb pdb:7DSX|reactome:R-HSA-2160916|reactome:R-HSA-425986	refseq:NP_009167.1|ensembl:ENSG00000187446(gene)|ensembl:ENST00000334660(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006903"(vesicle targeting)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0010923"(negative regulation of phosphatase activity)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019900"(kinase binding)|go:"GO:0022406"(membrane docking)|go:"GO:0030133"(transport vesicle)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032417"("positive regulation of sodium:proton antiporter activity")|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0060050"(positive regulation of protein glycosylation)|go:"GO:0061024"(membrane organization)|go:"GO:0061025"(membrane fusion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071073"(positive regulation of phospholipid biosynthetic process)|go:"GO:0071468"(cellular response to acidic pH)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1901214"(regulation of neuron death)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|rcsb pdb:2E30|rcsb pdb:7DSV|rcsb pdb:7DSX|reactome:R-HSA-2160916	-	-	-	figure legend:Fig.5A-C, Table 2, Supp. Fg. 7, Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:8.1x10^-9(molar)	2020/06/25	2020/06/25	rogid:wU1AHJ9CJrDPjiRZk2PhcO1OfDc9606	rogid:6/VeERuA4F0QeWlUj0pN8u0E6hc9606	rigid:iVmfTnwCHzP6oag9fpGpc+0qrLs	false	his tag:c-c|sufficient binding region:503-545|maltose binding protein tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43745	uniprotkb:P19634	intact:EBI-8525536|intact:MINT-2729920|uniprotkb:A8K2I8|ensembl:ENSP00000300113	intact:EBI-743635|uniprotkb:Q96EM2|ensembl:ENSP00000263980|uniprotkb:B1ALD6|uniprotkb:D3DPL4	psi-mi:chp2_human(display_long)|uniprotkb:CHP2(gene name)|psi-mi:CHP2(display_short)|uniprotkb:HCA520(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated antigen 520(gene name synonym)	psi-mi:sl9a1_human(display_long)|uniprotkb:"Na(+)/H(+) exchanger 1"(gene name synonym)|uniprotkb:Solute carrier family 9 member 1(gene name synonym)|uniprotkb:"Na(+)/H(+) antiporter, amiloride-sensitive"(gene name synonym)|uniprotkb:APNH(gene name synonym)|uniprotkb:SLC9A1(gene name)|psi-mi:SLC9A1(display_short)|uniprotkb:APNH1(gene name synonym)|uniprotkb:NHE1(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Liang et al. (2020)	imex:IM-28248|pubmed:31912575	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25684606|imex:IM-28248-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071380.1|ensembl:ENSG00000166869(gene)|ensembl:ENST00000300113(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0015031"(protein transport)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:O43745|rcsb pdb:2BEC	refseq:NP_003038.2|go:"GO:0009986"(cell surface)|ensembl:ENSG00000090020(gene)|ensembl:ENST00000263980(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0015299"("solute:proton antiporter activity")|go:"GO:0015385"("sodium:proton antiporter activity")|go:"GO:0015386"("potassium:proton antiporter activity")|go:"GO:0006811"(ion transport)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0006885"(regulation of pH)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030315"(T-tubule)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0016021"(integral component of membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070417"(cellular response to cold)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0070997"(neuron death)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071468"(cellular response to acidic pH)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086040"("sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential")|go:"GO:0086092"(regulation of the force of heart contraction by cardiac conduction)|go:"GO:0090533"(cation-transporting ATPase complex)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:1902600"(proton transmembrane transport)|go:"GO:1903281"("positive regulation of calcium:sodium antiporter activity")|interpro:IPR001970("Na+/H+ exchanger isoform 1 (NHE1)")|interpro:IPR004709(Sodium/hydrogen exchanger subfamily)|interpro:IPR006153(Sodium/hydrogen exchanger)|interpro:IPR018422|interpro:IPR032103|mint:P19634|rcsb pdb:1Y4E|rcsb pdb:2BEC|rcsb pdb:2E30|rcsb pdb:2HTG|rcsb pdb:2KBV|rcsb pdb:2L0E|rcsb pdb:2MDF|rcsb pdb:2YGG|rcsb pdb:6BJF|rcsb pdb:6NUC|rcsb pdb:6NUF|rcsb pdb:6NUU|rcsb pdb:6ZBI|rcsb pdb:7DSV|rcsb pdb:7DSW|rcsb pdb:7DSX|reactome:R-HSA-2160916|reactome:R-HSA-425986	-	comment:mint|function:Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death	-	figure legend:Fig.5D-F, Table 2, Supp. Fig. 9, Supp. Table 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.2x10^-8(molar)	2020/06/25	2020/06/25	rogid:UOhi/gx3k4psrhdl7xbrX/+A8Uo9606	rogid:wU1AHJ9CJrDPjiRZk2PhcO1OfDc9606	rigid:xri+F8B5r4C26YtkVcrjBZFKWag	false	-	his tag:c-c|sufficient binding region:503-545|maltose binding protein tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:29108"	uniprotkb:Q99653	intact:EBI-1169353	intact:EBI-722721|uniprotkb:Q6FHZ9|uniprotkb:B2R6H9|ensembl:ENSP00000335632	psi-mi:"calcium(2+)"(display_short)|psi-mi:"CHEBI:29108"(display_long)	psi-mi:chp1_human(display_long)|uniprotkb:CHP1(gene name)|psi-mi:CHP1(display_short)|uniprotkb:CHP(gene name synonym)|uniprotkb:Calcineurin B-like protein(gene name synonym)|uniprotkb:Calcium-binding protein CHP(gene name synonym)|uniprotkb:Calcium-binding protein p22(gene name synonym)|uniprotkb:EF-hand calcium-binding domain-containing protein p22(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Liang et al. (2020)	imex:IM-28248|pubmed:31912575	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25684618|imex:IM-28248-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_009167.1|ensembl:ENSG00000187446(gene)|ensembl:ENST00000334660(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006903"(vesicle targeting)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0010923"(negative regulation of phosphatase activity)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019900"(kinase binding)|go:"GO:0022406"(membrane docking)|go:"GO:0030133"(transport vesicle)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032417"("positive regulation of sodium:proton antiporter activity")|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0060050"(positive regulation of protein glycosylation)|go:"GO:0061024"(membrane organization)|go:"GO:0061025"(membrane fusion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071073"(positive regulation of phospholipid biosynthetic process)|go:"GO:0071468"(cellular response to acidic pH)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1901214"(regulation of neuron death)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|rcsb pdb:2E30|rcsb pdb:7DSV|rcsb pdb:7DSX|reactome:R-HSA-2160916	-	-	-	figure legend:Fig.5A-C, Table 2, Supp Fig. 6, Supp Table 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:7.7x10^-9(molar)	2020/06/25	2020/06/25	-	rogid:6/VeERuA4F0QeWlUj0pN8u0E6hc9606	-	false	-	sufficient binding region:2-195	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:29108"	uniprotkb:P19634	intact:EBI-1169353	intact:EBI-743635|uniprotkb:Q96EM2|ensembl:ENSP00000263980|uniprotkb:B1ALD6|uniprotkb:D3DPL4	psi-mi:"calcium(2+)"(display_short)|psi-mi:"CHEBI:29108"(display_long)	psi-mi:sl9a1_human(display_long)|uniprotkb:"Na(+)/H(+) exchanger 1"(gene name synonym)|uniprotkb:Solute carrier family 9 member 1(gene name synonym)|uniprotkb:"Na(+)/H(+) antiporter, amiloride-sensitive"(gene name synonym)|uniprotkb:APNH(gene name synonym)|uniprotkb:SLC9A1(gene name)|psi-mi:SLC9A1(display_short)|uniprotkb:APNH1(gene name synonym)|uniprotkb:NHE1(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Liang et al. (2020)	imex:IM-28248|pubmed:31912575	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25684618|imex:IM-28248-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003038.2|go:"GO:0009986"(cell surface)|ensembl:ENSG00000090020(gene)|ensembl:ENST00000263980(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0015299"("solute:proton antiporter activity")|go:"GO:0015385"("sodium:proton antiporter activity")|go:"GO:0015386"("potassium:proton antiporter activity")|go:"GO:0006811"(ion transport)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0006885"(regulation of pH)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030315"(T-tubule)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0016021"(integral component of membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070417"(cellular response to cold)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0070997"(neuron death)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071468"(cellular response to acidic pH)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086040"("sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential")|go:"GO:0086092"(regulation of the force of heart contraction by cardiac conduction)|go:"GO:0090533"(cation-transporting ATPase complex)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:1902600"(proton transmembrane transport)|go:"GO:1903281"("positive regulation of calcium:sodium antiporter activity")|interpro:IPR001970("Na+/H+ exchanger isoform 1 (NHE1)")|interpro:IPR004709(Sodium/hydrogen exchanger subfamily)|interpro:IPR006153(Sodium/hydrogen exchanger)|interpro:IPR018422|interpro:IPR032103|mint:P19634|rcsb pdb:1Y4E|rcsb pdb:2BEC|rcsb pdb:2E30|rcsb pdb:2HTG|rcsb pdb:2KBV|rcsb pdb:2L0E|rcsb pdb:2MDF|rcsb pdb:2YGG|rcsb pdb:6BJF|rcsb pdb:6NUC|rcsb pdb:6NUF|rcsb pdb:6NUU|rcsb pdb:6ZBI|rcsb pdb:7DSV|rcsb pdb:7DSW|rcsb pdb:7DSX|reactome:R-HSA-2160916|reactome:R-HSA-425986	-	-	-	figure legend:Fig.5A-C, Table 2, Supp Fig. 6, Supp Table 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:7.7x10^-9(molar)	2020/06/25	2020/06/25	-	rogid:wU1AHJ9CJrDPjiRZk2PhcO1OfDc9606	-	false	-	his tag:c-c|sufficient binding region:503-545|maltose binding protein tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:29108"	uniprotkb:O43745	intact:EBI-1169353	intact:EBI-8525536|intact:MINT-2729920|uniprotkb:A8K2I8|ensembl:ENSP00000300113	psi-mi:"calcium(2+)"(display_short)|psi-mi:"CHEBI:29108"(display_long)	psi-mi:chp2_human(display_long)|uniprotkb:CHP2(gene name)|psi-mi:CHP2(display_short)|uniprotkb:HCA520(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated antigen 520(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Liang et al. (2020)	imex:IM-28248|pubmed:31912575	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25684633|imex:IM-28248-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_071380.1|ensembl:ENSG00000166869(gene)|ensembl:ENST00000300113(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0015031"(protein transport)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:O43745|rcsb pdb:2BEC	-	-	comment:mint|function:Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death	figure legend:Fig.5D-F, Table 2, Supp. Fig. 8, Supp. Table 5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:3.2x10^-9(molar)	2020/06/25	2020/06/25	-	rogid:UOhi/gx3k4psrhdl7xbrX/+A8Uo9606	-	false	-	sufficient binding region:2-196	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:29108"	uniprotkb:P19634	intact:EBI-1169353	intact:EBI-743635|uniprotkb:Q96EM2|ensembl:ENSP00000263980|uniprotkb:B1ALD6|uniprotkb:D3DPL4	psi-mi:"calcium(2+)"(display_short)|psi-mi:"CHEBI:29108"(display_long)	psi-mi:sl9a1_human(display_long)|uniprotkb:"Na(+)/H(+) exchanger 1"(gene name synonym)|uniprotkb:Solute carrier family 9 member 1(gene name synonym)|uniprotkb:"Na(+)/H(+) antiporter, amiloride-sensitive"(gene name synonym)|uniprotkb:APNH(gene name synonym)|uniprotkb:SLC9A1(gene name)|psi-mi:SLC9A1(display_short)|uniprotkb:APNH1(gene name synonym)|uniprotkb:NHE1(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Liang et al. (2020)	imex:IM-28248|pubmed:31912575	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25684633|imex:IM-28248-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003038.2|go:"GO:0009986"(cell surface)|ensembl:ENSG00000090020(gene)|ensembl:ENST00000263980(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0015299"("solute:proton antiporter activity")|go:"GO:0015385"("sodium:proton antiporter activity")|go:"GO:0015386"("potassium:proton antiporter activity")|go:"GO:0006811"(ion transport)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0006885"(regulation of pH)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030315"(T-tubule)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0016021"(integral component of membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070417"(cellular response to cold)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0070997"(neuron death)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071468"(cellular response to acidic pH)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086040"("sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential")|go:"GO:0086092"(regulation of the force of heart contraction by cardiac conduction)|go:"GO:0090533"(cation-transporting ATPase complex)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:1902600"(proton transmembrane transport)|go:"GO:1903281"("positive regulation of calcium:sodium antiporter activity")|interpro:IPR001970("Na+/H+ exchanger isoform 1 (NHE1)")|interpro:IPR004709(Sodium/hydrogen exchanger subfamily)|interpro:IPR006153(Sodium/hydrogen exchanger)|interpro:IPR018422|interpro:IPR032103|mint:P19634|rcsb pdb:1Y4E|rcsb pdb:2BEC|rcsb pdb:2E30|rcsb pdb:2HTG|rcsb pdb:2KBV|rcsb pdb:2L0E|rcsb pdb:2MDF|rcsb pdb:2YGG|rcsb pdb:6BJF|rcsb pdb:6NUC|rcsb pdb:6NUF|rcsb pdb:6NUU|rcsb pdb:6ZBI|rcsb pdb:7DSV|rcsb pdb:7DSW|rcsb pdb:7DSX|reactome:R-HSA-2160916|reactome:R-HSA-425986	-	-	-	figure legend:Fig.5D-F, Table 2, Supp. Fig. 8, Supp. Table 5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:3.2x10^-9(molar)	2020/06/25	2020/06/25	-	rogid:wU1AHJ9CJrDPjiRZk2PhcO1OfDc9606	-	false	-	his tag:c-c|sufficient binding region:503-545|maltose binding protein tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)