#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9NRM0-1	uniprotkb:Q9Y287	intact:EBI-25396304|ensembl:ENSP00000264784	intact:EBI-2866431|uniprotkb:Q5W0A3|uniprotkb:Q96B24|uniprotkb:Q9NYH1|ensembl:ENSP00000497221	psi-mi:q9nrm0-1(display_long)|uniprotkb:Glucose transporter type 9(gene name synonym)|uniprotkb:Urate transporter(gene name synonym)|uniprotkb:SLC2A9-L(isoform synonym)|uniprotkb:SLC2A9(gene name)|psi-mi:SLC2A9(display_short)|uniprotkb:GLUT9(gene name synonym)	psi-mi:itm2b_human(display_long)|uniprotkb:ITM2B(gene name)|psi-mi:ITM2B(display_short)|uniprotkb:BRI(gene name synonym)|uniprotkb:BRI2(gene name synonym)|uniprotkb:Protein E25B(gene name synonym)|uniprotkb:Transmembrane protein BRI(gene name synonym)|uniprotkb:Immature BRI2(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mandal et al. (2018)	pubmed:31695625|imex:IM-27950	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25396312|imex:IM-27950-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000264784(transcript)|ensembl:ENSG00000109667(gene)|intact:EBI-25396457(isoform-parent)	refseq:NP_068839.1|ensembl:ENSG00000136156(gene)|ensembl:ENST00000647800(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070062"(extracellular exosome)|interpro:IPR007084(BRICHOS)|interpro:IPR040145|reactome:R-HSA-977225	-	-	-	figure legend:Supp. Fib 1A, 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/01/11	2020/01/13	rogid:rz+H/1AQDXIi5KvOrv4rCYRgZO89606	rogid:9mHhC4Z61CsmOsTh/1K9oj2NezA9606	rigid:ts0YbHMThudlLdBC8EJmjdP7GYw	false	cub:n-n	nub:c-c	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NRM0-1	uniprotkb:Q5J8M3	intact:EBI-25396304|ensembl:ENSP00000264784	intact:EBI-2814031|uniprotkb:Q9P0T9|uniprotkb:Q96KX9|uniprotkb:B4DJQ4|uniprotkb:Q9BUI5|uniprotkb:A8K3A9|ensembl:ENSP00000267750	psi-mi:q9nrm0-1(display_long)|uniprotkb:Glucose transporter type 9(gene name synonym)|uniprotkb:Urate transporter(gene name synonym)|uniprotkb:SLC2A9-L(isoform synonym)|uniprotkb:SLC2A9(gene name)|psi-mi:SLC2A9(display_short)|uniprotkb:GLUT9(gene name synonym)	psi-mi:emc4_human(display_long)|uniprotkb:EMC4(gene name)|psi-mi:EMC4(display_short)|uniprotkb:Cell proliferation-inducing gene 17 protein(gene name synonym)|uniprotkb:TMEM85(gene name synonym)|uniprotkb:Transmembrane protein 85(gene name synonym)|uniprotkb:HSPC184(orf name)|uniprotkb:PIG17(orf name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mandal et al. (2018)	pubmed:31695625|imex:IM-27950	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25396316|imex:IM-27950-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000264784(transcript)|ensembl:ENSG00000109667(gene)|intact:EBI-25396457(isoform-parent)	refseq:NP_001273349.1|refseq:NP_057538.1|ensembl:ENSG00000128463(gene)|ensembl:ENST00000267750(transcript)|go:"GO:0006915"(apoptotic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0045050"(protein insertion into ER membrane by stop-transfer membrane-anchor sequence)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0072546"(EMC complex)|interpro:IPR009445(Protein of unknown function DUF1077)|rcsb pdb:6Z3W|rcsb pdb:7ADO|rcsb pdb:7ADP|go:"GO:0016021"(integral component of membrane)	-	-	-	figure legend:Supp. Fig 1A, 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/01/11	2020/01/13	rogid:rz+H/1AQDXIi5KvOrv4rCYRgZO89606	rogid:b6qUbq3mJhmXTtZFctD6xd4E1jQ9606	rigid:V+s8CAKuNwBwEqY5b6b1n1BBPAU	false	cub:n-n	nub:c-c	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NRM0-1	uniprotkb:Q9Y287	intact:EBI-25396304|ensembl:ENSP00000264784	intact:EBI-2866431|uniprotkb:Q5W0A3|uniprotkb:Q96B24|uniprotkb:Q9NYH1|ensembl:ENSP00000497221	psi-mi:q9nrm0-1(display_long)|uniprotkb:Glucose transporter type 9(gene name synonym)|uniprotkb:Urate transporter(gene name synonym)|uniprotkb:SLC2A9-L(isoform synonym)|uniprotkb:SLC2A9(gene name)|psi-mi:SLC2A9(display_short)|uniprotkb:GLUT9(gene name synonym)	psi-mi:itm2b_human(display_long)|uniprotkb:ITM2B(gene name)|psi-mi:ITM2B(display_short)|uniprotkb:BRI(gene name synonym)|uniprotkb:BRI2(gene name synonym)|uniprotkb:Protein E25B(gene name synonym)|uniprotkb:Transmembrane protein BRI(gene name synonym)|uniprotkb:Immature BRI2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mandal et al. (2018)	pubmed:31695625|imex:IM-27950	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25396332|imex:IM-27950-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000264784(transcript)|ensembl:ENSG00000109667(gene)|intact:EBI-25396457(isoform-parent)	refseq:NP_068839.1|ensembl:ENSG00000136156(gene)|ensembl:ENST00000647800(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070062"(extracellular exosome)|interpro:IPR007084(BRICHOS)|interpro:IPR040145|reactome:R-HSA-977225	-	-	-	figure legend:Fig 1C, 6A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/01/11	2020/01/14	rogid:rz+H/1AQDXIi5KvOrv4rCYRgZO89606	rogid:9mHhC4Z61CsmOsTh/1K9oj2NezA9606	rigid:ts0YbHMThudlLdBC8EJmjdP7GYw	false	mutation with no effect:90-90	myc tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NRM0-1	uniprotkb:Q5J8M3	intact:EBI-25396304|ensembl:ENSP00000264784	intact:EBI-2814031|uniprotkb:Q9P0T9|uniprotkb:Q96KX9|uniprotkb:B4DJQ4|uniprotkb:Q9BUI5|uniprotkb:A8K3A9|ensembl:ENSP00000267750	psi-mi:q9nrm0-1(display_long)|uniprotkb:Glucose transporter type 9(gene name synonym)|uniprotkb:Urate transporter(gene name synonym)|uniprotkb:SLC2A9-L(isoform synonym)|uniprotkb:SLC2A9(gene name)|psi-mi:SLC2A9(display_short)|uniprotkb:GLUT9(gene name synonym)	psi-mi:emc4_human(display_long)|uniprotkb:EMC4(gene name)|psi-mi:EMC4(display_short)|uniprotkb:Cell proliferation-inducing gene 17 protein(gene name synonym)|uniprotkb:TMEM85(gene name synonym)|uniprotkb:Transmembrane protein 85(gene name synonym)|uniprotkb:HSPC184(orf name)|uniprotkb:PIG17(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mandal et al. (2018)	pubmed:31695625|imex:IM-27950	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25396336|imex:IM-27950-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000264784(transcript)|ensembl:ENSG00000109667(gene)|intact:EBI-25396457(isoform-parent)	refseq:NP_001273349.1|refseq:NP_057538.1|ensembl:ENSG00000128463(gene)|ensembl:ENST00000267750(transcript)|go:"GO:0006915"(apoptotic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0045050"(protein insertion into ER membrane by stop-transfer membrane-anchor sequence)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0072546"(EMC complex)|interpro:IPR009445(Protein of unknown function DUF1077)|rcsb pdb:6Z3W|rcsb pdb:7ADO|rcsb pdb:7ADP|go:"GO:0016021"(integral component of membrane)	-	-	-	figure legend:Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/01/11	2020/06/03	rogid:rz+H/1AQDXIi5KvOrv4rCYRgZO89606	rogid:b6qUbq3mJhmXTtZFctD6xd4E1jQ9606	rigid:V+s8CAKuNwBwEqY5b6b1n1BBPAU	false	-	myc tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NRM0-2	uniprotkb:Q9Y287	intact:EBI-25396386|ensembl:ENSP00000311383|ensembl:ENSP00000422209	intact:EBI-2866431|uniprotkb:Q5W0A3|uniprotkb:Q96B24|uniprotkb:Q9NYH1|ensembl:ENSP00000497221	psi-mi:q9nrm0-2(display_long)|uniprotkb:Glucose transporter type 9(gene name synonym)|uniprotkb:Urate transporter(gene name synonym)|uniprotkb:GLUT9deltaN(isoform synonym)|uniprotkb:SLC2A9-S(isoform synonym)|uniprotkb:SLC2A9(gene name)|psi-mi:SLC2A9(display_short)|uniprotkb:GLUT9(gene name synonym)	psi-mi:itm2b_human(display_long)|uniprotkb:ITM2B(gene name)|psi-mi:ITM2B(display_short)|uniprotkb:BRI(gene name synonym)|uniprotkb:BRI2(gene name synonym)|uniprotkb:Protein E25B(gene name synonym)|uniprotkb:Transmembrane protein BRI(gene name synonym)|uniprotkb:Immature BRI2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mandal et al. (2018)	pubmed:31695625|imex:IM-27950	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25396395|imex:IM-27950-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000109667(gene)|ensembl:ENST00000309065(transcript)|ensembl:ENST00000506583(transcript)|intact:EBI-25396457(isoform-parent)	refseq:NP_068839.1|ensembl:ENSG00000136156(gene)|ensembl:ENST00000647800(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070062"(extracellular exosome)|interpro:IPR007084(BRICHOS)|interpro:IPR040145|reactome:R-HSA-977225	-	-	-	figure legend:Fig 1C, 6A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/01/11	2020/01/13	rogid:Y95e7AXN0MWJxqpf93zyFKTHfoM9606	rogid:9mHhC4Z61CsmOsTh/1K9oj2NezA9606	rigid:XT+QKSJrfWIjWsP+PRr/FRP2cmw	false	mutation with no effect:61-61	myc tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NRM0-2	uniprotkb:Q5J8M3	intact:EBI-25396386|ensembl:ENSP00000311383|ensembl:ENSP00000422209	intact:EBI-2814031|uniprotkb:Q9P0T9|uniprotkb:Q96KX9|uniprotkb:B4DJQ4|uniprotkb:Q9BUI5|uniprotkb:A8K3A9|ensembl:ENSP00000267750	psi-mi:q9nrm0-2(display_long)|uniprotkb:Glucose transporter type 9(gene name synonym)|uniprotkb:Urate transporter(gene name synonym)|uniprotkb:GLUT9deltaN(isoform synonym)|uniprotkb:SLC2A9-S(isoform synonym)|uniprotkb:SLC2A9(gene name)|psi-mi:SLC2A9(display_short)|uniprotkb:GLUT9(gene name synonym)	psi-mi:emc4_human(display_long)|uniprotkb:EMC4(gene name)|psi-mi:EMC4(display_short)|uniprotkb:Cell proliferation-inducing gene 17 protein(gene name synonym)|uniprotkb:TMEM85(gene name synonym)|uniprotkb:Transmembrane protein 85(gene name synonym)|uniprotkb:HSPC184(orf name)|uniprotkb:PIG17(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mandal et al. (2018)	pubmed:31695625|imex:IM-27950	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25396406|imex:IM-27950-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000109667(gene)|ensembl:ENST00000309065(transcript)|ensembl:ENST00000506583(transcript)|intact:EBI-25396457(isoform-parent)	refseq:NP_001273349.1|refseq:NP_057538.1|ensembl:ENSG00000128463(gene)|ensembl:ENST00000267750(transcript)|go:"GO:0006915"(apoptotic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0045050"(protein insertion into ER membrane by stop-transfer membrane-anchor sequence)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0072546"(EMC complex)|interpro:IPR009445(Protein of unknown function DUF1077)|rcsb pdb:6Z3W|rcsb pdb:7ADO|rcsb pdb:7ADP|go:"GO:0016021"(integral component of membrane)	-	-	-	figure legend:Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/01/11	2020/06/03	rogid:Y95e7AXN0MWJxqpf93zyFKTHfoM9606	rogid:b6qUbq3mJhmXTtZFctD6xd4E1jQ9606	rigid:GiED2pNY8CSaT/pxGwKn+HWhyp0	false	-	myc tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NRM0-2	uniprotkb:Q9Y287	intact:EBI-25396386|ensembl:ENSP00000311383|ensembl:ENSP00000422209	intact:EBI-2866431|uniprotkb:Q5W0A3|uniprotkb:Q96B24|uniprotkb:Q9NYH1|ensembl:ENSP00000497221	psi-mi:q9nrm0-2(display_long)|uniprotkb:Glucose transporter type 9(gene name synonym)|uniprotkb:Urate transporter(gene name synonym)|uniprotkb:GLUT9deltaN(isoform synonym)|uniprotkb:SLC2A9-S(isoform synonym)|uniprotkb:SLC2A9(gene name)|psi-mi:SLC2A9(display_short)|uniprotkb:GLUT9(gene name synonym)	psi-mi:itm2b_human(display_long)|uniprotkb:ITM2B(gene name)|psi-mi:ITM2B(display_short)|uniprotkb:BRI(gene name synonym)|uniprotkb:BRI2(gene name synonym)|uniprotkb:Protein E25B(gene name synonym)|uniprotkb:Transmembrane protein BRI(gene name synonym)|uniprotkb:Immature BRI2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mandal et al. (2018)	pubmed:31695625|imex:IM-27950	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25396430|imex:IM-27950-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000109667(gene)|ensembl:ENST00000309065(transcript)|ensembl:ENST00000506583(transcript)|intact:EBI-25396457(isoform-parent)	refseq:NP_068839.1|ensembl:ENSG00000136156(gene)|ensembl:ENST00000647800(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070062"(extracellular exosome)|interpro:IPR007084(BRICHOS)|interpro:IPR040145|reactome:R-HSA-977225|clinvar:VCV000005979.1(identity)	-	-	-	figure legend:Fig 1D, 6B, 8E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla-oocyte)|taxid:8355(Xenopus laevis)	-	2020/01/11	2020/01/13	rogid:Y95e7AXN0MWJxqpf93zyFKTHfoM9606	rogid:9mHhC4Z61CsmOsTh/1K9oj2NezA9606	rigid:XT+QKSJrfWIjWsP+PRr/FRP2cmw	false	mutation disrupting interaction strength:61-61	myc tag:?-?|mutation with no effect:266-266|mutation with no effect:266-266(VCV000005980.1)|mutation with no effect:261-261(VCV000157606.1)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NRM0-1	uniprotkb:Q5J8M3	intact:EBI-25396304|ensembl:ENSP00000264784	intact:EBI-2814031|uniprotkb:Q9P0T9|uniprotkb:Q96KX9|uniprotkb:B4DJQ4|uniprotkb:Q9BUI5|uniprotkb:A8K3A9|ensembl:ENSP00000267750	psi-mi:q9nrm0-1(display_long)|uniprotkb:Glucose transporter type 9(gene name synonym)|uniprotkb:Urate transporter(gene name synonym)|uniprotkb:SLC2A9-L(isoform synonym)|uniprotkb:SLC2A9(gene name)|psi-mi:SLC2A9(display_short)|uniprotkb:GLUT9(gene name synonym)	psi-mi:emc4_human(display_long)|uniprotkb:EMC4(gene name)|psi-mi:EMC4(display_short)|uniprotkb:Cell proliferation-inducing gene 17 protein(gene name synonym)|uniprotkb:TMEM85(gene name synonym)|uniprotkb:Transmembrane protein 85(gene name synonym)|uniprotkb:HSPC184(orf name)|uniprotkb:PIG17(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mandal et al. (2018)	pubmed:31695625|imex:IM-27950	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25396418|imex:IM-27950-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000264784(transcript)|ensembl:ENSG00000109667(gene)|intact:EBI-25396457(isoform-parent)	refseq:NP_001273349.1|refseq:NP_057538.1|ensembl:ENSG00000128463(gene)|ensembl:ENST00000267750(transcript)|go:"GO:0006915"(apoptotic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0045050"(protein insertion into ER membrane by stop-transfer membrane-anchor sequence)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0072546"(EMC complex)|interpro:IPR009445(Protein of unknown function DUF1077)|rcsb pdb:6Z3W|rcsb pdb:7ADO|rcsb pdb:7ADP|go:"GO:0016021"(integral component of membrane)	-	-	-	figure legend:Fig. 1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla-oocyte)|taxid:8355(Xenopus laevis)	-	2020/01/11	2020/01/13	rogid:rz+H/1AQDXIi5KvOrv4rCYRgZO89606	rogid:b6qUbq3mJhmXTtZFctD6xd4E1jQ9606	rigid:V+s8CAKuNwBwEqY5b6b1n1BBPAU	false	-	myc tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NRM0-2	uniprotkb:Q5J8M3	intact:EBI-25396386|ensembl:ENSP00000311383|ensembl:ENSP00000422209	intact:EBI-2814031|uniprotkb:Q9P0T9|uniprotkb:Q96KX9|uniprotkb:B4DJQ4|uniprotkb:Q9BUI5|uniprotkb:A8K3A9|ensembl:ENSP00000267750	psi-mi:q9nrm0-2(display_long)|uniprotkb:Glucose transporter type 9(gene name synonym)|uniprotkb:Urate transporter(gene name synonym)|uniprotkb:GLUT9deltaN(isoform synonym)|uniprotkb:SLC2A9-S(isoform synonym)|uniprotkb:SLC2A9(gene name)|psi-mi:SLC2A9(display_short)|uniprotkb:GLUT9(gene name synonym)	psi-mi:emc4_human(display_long)|uniprotkb:EMC4(gene name)|psi-mi:EMC4(display_short)|uniprotkb:Cell proliferation-inducing gene 17 protein(gene name synonym)|uniprotkb:TMEM85(gene name synonym)|uniprotkb:Transmembrane protein 85(gene name synonym)|uniprotkb:HSPC184(orf name)|uniprotkb:PIG17(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mandal et al. (2018)	pubmed:31695625|imex:IM-27950	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25396436|imex:IM-27950-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000109667(gene)|ensembl:ENST00000309065(transcript)|ensembl:ENST00000506583(transcript)|intact:EBI-25396457(isoform-parent)	refseq:NP_001273349.1|refseq:NP_057538.1|ensembl:ENSG00000128463(gene)|ensembl:ENST00000267750(transcript)|go:"GO:0006915"(apoptotic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0045050"(protein insertion into ER membrane by stop-transfer membrane-anchor sequence)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0072546"(EMC complex)|interpro:IPR009445(Protein of unknown function DUF1077)|rcsb pdb:6Z3W|rcsb pdb:7ADO|rcsb pdb:7ADP|go:"GO:0016021"(integral component of membrane)	-	-	-	figure legend:Fig. 1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla-oocyte)|taxid:8355(Xenopus laevis)	-	2020/01/11	2020/01/13	rogid:Y95e7AXN0MWJxqpf93zyFKTHfoM9606	rogid:b6qUbq3mJhmXTtZFctD6xd4E1jQ9606	rigid:GiED2pNY8CSaT/pxGwKn+HWhyp0	false	-	myc tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NRM0-1	uniprotkb:Q9Y287	intact:EBI-25396304|ensembl:ENSP00000264784	intact:EBI-2866431|uniprotkb:Q5W0A3|uniprotkb:Q96B24|uniprotkb:Q9NYH1|ensembl:ENSP00000497221	psi-mi:q9nrm0-1(display_long)|uniprotkb:Glucose transporter type 9(gene name synonym)|uniprotkb:Urate transporter(gene name synonym)|uniprotkb:SLC2A9-L(isoform synonym)|uniprotkb:SLC2A9(gene name)|psi-mi:SLC2A9(display_short)|uniprotkb:GLUT9(gene name synonym)	psi-mi:itm2b_human(display_long)|uniprotkb:ITM2B(gene name)|psi-mi:ITM2B(display_short)|uniprotkb:BRI(gene name synonym)|uniprotkb:BRI2(gene name synonym)|uniprotkb:Protein E25B(gene name synonym)|uniprotkb:Transmembrane protein BRI(gene name synonym)|uniprotkb:Immature BRI2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mandal et al. (2018)	pubmed:31695625|imex:IM-27950	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25396424|imex:IM-27950-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000264784(transcript)|ensembl:ENSG00000109667(gene)|intact:EBI-25396457(isoform-parent)	refseq:NP_068839.1|ensembl:ENSG00000136156(gene)|ensembl:ENST00000647800(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070062"(extracellular exosome)|interpro:IPR007084(BRICHOS)|interpro:IPR040145|reactome:R-HSA-977225	-	-	-	figure legend:Fig 1D, 6B, 8E, 8F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla-oocyte)|taxid:8355(Xenopus laevis)	-	2020/01/11	2020/01/13	rogid:rz+H/1AQDXIi5KvOrv4rCYRgZO89606	rogid:9mHhC4Z61CsmOsTh/1K9oj2NezA9606	rigid:ts0YbHMThudlLdBC8EJmjdP7GYw	false	mutation with no effect:90-90	myc tag:?-?|mutation with no effect:266-266(VCV000005979.1)|mutation with no effect:266-266(VCV000005980.1)|mutation with no effect:261-261(VCV000157606.1)|mutation decreasing interaction strength:170-170	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NRM0	uniprotkb:Q9Y287	intact:EBI-25396457|uniprotkb:Q96P00|uniprotkb:Q8WV30|ensembl:ENSP00000264784|uniprotkb:Q0VGC4|uniprotkb:Q4W5D1	intact:EBI-2866431|uniprotkb:Q5W0A3|uniprotkb:Q96B24|uniprotkb:Q9NYH1|ensembl:ENSP00000497221	psi-mi:gtr9_human(display_long)|uniprotkb:Glucose transporter type 9(gene name synonym)|uniprotkb:Urate transporter(gene name synonym)|uniprotkb:SLC2A9(gene name)|psi-mi:SLC2A9(display_short)|uniprotkb:GLUT9(gene name synonym)	psi-mi:itm2b_human(display_long)|uniprotkb:ITM2B(gene name)|psi-mi:ITM2B(display_short)|uniprotkb:BRI(gene name synonym)|uniprotkb:BRI2(gene name synonym)|uniprotkb:Protein E25B(gene name synonym)|uniprotkb:Transmembrane protein BRI(gene name synonym)|uniprotkb:Immature BRI2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mandal et al. (2018)	pubmed:31695625|imex:IM-27950	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25396550|imex:IM-27950-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001001290.1|refseq:NP_064425.2|ensembl:ENSG00000109667(gene)|ensembl:ENST00000264784(transcript)|go:"GO:0005351"("carbohydrate:proton symporter activity")|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0008645"(hexose transmembrane transport)|go:"GO:0015143"(urate transmembrane transporter activity)|go:"GO:0015747"(urate transport)|go:"GO:0015755"(fructose transmembrane transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0046415"(urate metabolic process)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-HSA-189200|reactome:R-HSA-5619047	refseq:NP_068839.1|ensembl:ENSG00000136156(gene)|ensembl:ENST00000647800(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070062"(extracellular exosome)|interpro:IPR007084(BRICHOS)|interpro:IPR040145|reactome:R-HSA-977225	-	-	-	figure legend:Fig 1E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-caco2)|taxid:9606(Human Caucasian colon adenocarcinoma)	-	2020/01/11	2020/01/13	rogid:rz+H/1AQDXIi5KvOrv4rCYRgZO89606	rogid:9mHhC4Z61CsmOsTh/1K9oj2NezA9606	rigid:ts0YbHMThudlLdBC8EJmjdP7GYw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NRM0-1	uniprotkb:Q9Y287	intact:EBI-25396304|ensembl:ENSP00000264784	intact:EBI-2866431|uniprotkb:Q5W0A3|uniprotkb:Q96B24|uniprotkb:Q9NYH1|ensembl:ENSP00000497221	psi-mi:q9nrm0-1(display_long)|uniprotkb:Glucose transporter type 9(gene name synonym)|uniprotkb:Urate transporter(gene name synonym)|uniprotkb:SLC2A9-L(isoform synonym)|uniprotkb:SLC2A9(gene name)|psi-mi:SLC2A9(display_short)|uniprotkb:GLUT9(gene name synonym)	psi-mi:itm2b_human(display_long)|uniprotkb:ITM2B(gene name)|psi-mi:ITM2B(display_short)|uniprotkb:BRI(gene name synonym)|uniprotkb:BRI2(gene name synonym)|uniprotkb:Protein E25B(gene name synonym)|uniprotkb:Transmembrane protein BRI(gene name synonym)|uniprotkb:Immature BRI2(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Mandal et al. (2018)	pubmed:31695625|imex:IM-27950	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25396562|imex:IM-27950-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000264784(transcript)|ensembl:ENSG00000109667(gene)|intact:EBI-25396457(isoform-parent)	refseq:NP_068839.1|ensembl:ENSG00000136156(gene)|ensembl:ENST00000647800(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070062"(extracellular exosome)|interpro:IPR007084(BRICHOS)|interpro:IPR040145|reactome:R-HSA-977225	go:"GO:0005886"(plasma membrane)	-	-	figure legend:Fig 2G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/01/11	2020/01/14	rogid:rz+H/1AQDXIi5KvOrv4rCYRgZO89606	rogid:9mHhC4Z61CsmOsTh/1K9oj2NezA9606	rigid:ts0YbHMThudlLdBC8EJmjdP7GYw	false	-	myc tag:?-?	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)