#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q1HVL3	uniprotkb:P15144	intact:EBI-25474287	intact:EBI-2563898|uniprotkb:Q16728|uniprotkb:Q9UCE0|uniprotkb:Q8IVH3|uniprotkb:Q8IUK3|uniprotkb:Q6GT90|ensembl:ENSP00000300060|ensembl:ENSP00000452934|ensembl:ENSP00000453413|ensembl:ENSP00000502886	psi-mi:q1hvl3_cvh22(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)	psi-mi:ampn_human(display_long)|uniprotkb:APN(gene name synonym)|uniprotkb:CD13(gene name synonym)|uniprotkb:PEPN(gene name synonym)|uniprotkb:Alanyl aminopeptidase(gene name synonym)|uniprotkb:Microsomal aminopeptidase(gene name synonym)|uniprotkb:Aminopeptidase M(gene name synonym)|uniprotkb:gp150(gene name synonym)|uniprotkb:Myeloid plasma membrane glycoprotein CD13(gene name synonym)|uniprotkb:ANPEP(gene name)|psi-mi:ANPEP(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Li et al. (2019)	pubmed:31650956|imex:IM-27809	taxid:11137(hcov-229e)|taxid:11137(Human coronavirus 229E)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25474298|pdbe:6U7F|imex:IM-27809-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR044873|interpro:IPR044874|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|interpro:IPR043473|interpro:IPR002551(Coronavirus S1 glycoprotein)|interpro:IPR002552(Coronavirus S2 glycoprotein)|rcsb pdb:6U7F|interpro:IPR043607|interpro:IPR043614	refseq:NP_001141.2|refseq:XP_011519775.1|ensembl:ENSG00000166825(gene)|ensembl:ENST00000300060(transcript)|ensembl:ENST00000559874(transcript)|ensembl:ENST00000560137(transcript)|ensembl:ENST00000679248(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001618"(virus receptor activity)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0007165"(signal transduction)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042277"(peptide binding)|go:"GO:0043171"(peptide catabolic process)|go:"GO:0070006"(metalloaminopeptidase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001930(Peptidase M1, membrane alanine aminopeptidase)|interpro:IPR014782(Peptidase M1, membrane alanine aminopeptidase, N-terminal)|interpro:IPR024571|interpro:IPR027268|interpro:IPR034016|interpro:IPR042097|rcsb pdb:4FYQ|rcsb pdb:4FYR|rcsb pdb:4FYS|rcsb pdb:4FYT|rcsb pdb:5LHD|rcsb pdb:6ATK|rcsb pdb:6U7E|rcsb pdb:6U7F|rcsb pdb:6U7G|rcsb pdb:6XWD|rcsb pdb:7AEW|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_005254949.1	-	-	-	figure legend:Supp. File 2|3d-resolution:2.75Å|3d-r-factors:Rwork - 0.19  Rfree - 0.225|comment:S protein uniprot accession was taken as Q1HVL3 from the given genbank accession ABB90519.1|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/20	2020/03/20	rogid:OsGv/KyEL0zfDe/q0GKfaJTD10M11137	rogid:rKOeK87j6V1zOyRYGR7v2CHuZn09606	rigid:HiFKVFR/9l9OCSHwyq8A2NLbx/k	false	sufficient binding region:292-432	sufficient binding region:66-967	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q1HVL8	uniprotkb:P15144	intact:EBI-25492134	intact:EBI-2563898|uniprotkb:Q16728|uniprotkb:Q9UCE0|uniprotkb:Q8IVH3|uniprotkb:Q8IUK3|uniprotkb:Q6GT90|ensembl:ENSP00000300060|ensembl:ENSP00000452934|ensembl:ENSP00000453413|ensembl:ENSP00000502886	psi-mi:q1hvl8_cvh22(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)	psi-mi:ampn_human(display_long)|uniprotkb:APN(gene name synonym)|uniprotkb:CD13(gene name synonym)|uniprotkb:PEPN(gene name synonym)|uniprotkb:Alanyl aminopeptidase(gene name synonym)|uniprotkb:Microsomal aminopeptidase(gene name synonym)|uniprotkb:Aminopeptidase M(gene name synonym)|uniprotkb:gp150(gene name synonym)|uniprotkb:Myeloid plasma membrane glycoprotein CD13(gene name synonym)|uniprotkb:ANPEP(gene name)|psi-mi:ANPEP(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Li et al. (2019)	pubmed:31650956|imex:IM-27809	taxid:11137(hcov-229e)|taxid:11137(Human coronavirus 229E)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25492112|imex:IM-27809-4|pdbe:6U7E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR044873|interpro:IPR044874|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|interpro:IPR042552|interpro:IPR002551(Coronavirus S1 glycoprotein)|interpro:IPR002552(Coronavirus S2 glycoprotein)|rcsb pdb:6U7E|interpro:IPR043473|interpro:IPR043607|interpro:IPR043614	refseq:NP_001141.2|refseq:XP_011519775.1|ensembl:ENSG00000166825(gene)|ensembl:ENST00000300060(transcript)|ensembl:ENST00000559874(transcript)|ensembl:ENST00000560137(transcript)|ensembl:ENST00000679248(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001618"(virus receptor activity)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0007165"(signal transduction)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042277"(peptide binding)|go:"GO:0043171"(peptide catabolic process)|go:"GO:0070006"(metalloaminopeptidase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001930(Peptidase M1, membrane alanine aminopeptidase)|interpro:IPR014782(Peptidase M1, membrane alanine aminopeptidase, N-terminal)|interpro:IPR024571|interpro:IPR027268|interpro:IPR034016|interpro:IPR042097|rcsb pdb:4FYQ|rcsb pdb:4FYR|rcsb pdb:4FYS|rcsb pdb:4FYT|rcsb pdb:5LHD|rcsb pdb:6ATK|rcsb pdb:6U7E|rcsb pdb:6U7F|rcsb pdb:6U7G|rcsb pdb:6XWD|rcsb pdb:7AEW|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_005254949.1	-	-	-	figure legend:Supp. File 2|comment:S protein accession was confirmed to be Q1HVL8 from given genbank accession ABB90514.1|3d-resolution:3Å|3d-r-factors:Rfree - 0.204  Rwork - 0.244|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/20	2020/03/26	rogid:WTMAIJesmImC166tAlH0KlO7AcU11137	rogid:rKOeK87j6V1zOyRYGR7v2CHuZn09606	rigid:zqACwurPVylRXQPDeTyo0CUpc8s	false	sufficient binding region:292-432	sufficient binding region:66-967	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q1HVK9	uniprotkb:P15144	intact:EBI-25492173	intact:EBI-2563898|uniprotkb:Q16728|uniprotkb:Q9UCE0|uniprotkb:Q8IVH3|uniprotkb:Q8IUK3|uniprotkb:Q6GT90|ensembl:ENSP00000300060|ensembl:ENSP00000452934|ensembl:ENSP00000453413|ensembl:ENSP00000502886	psi-mi:q1hvk9_cvh22(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)	psi-mi:ampn_human(display_long)|uniprotkb:APN(gene name synonym)|uniprotkb:CD13(gene name synonym)|uniprotkb:PEPN(gene name synonym)|uniprotkb:Alanyl aminopeptidase(gene name synonym)|uniprotkb:Microsomal aminopeptidase(gene name synonym)|uniprotkb:Aminopeptidase M(gene name synonym)|uniprotkb:gp150(gene name synonym)|uniprotkb:Myeloid plasma membrane glycoprotein CD13(gene name synonym)|uniprotkb:ANPEP(gene name)|psi-mi:ANPEP(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Li et al. (2019)	pubmed:31650956|imex:IM-27809	taxid:11137(hcov-229e)|taxid:11137(Human coronavirus 229E)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25492165|imex:IM-27809-6|pdbe:6U7G	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR044873|interpro:IPR044874|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|interpro:IPR002551(Coronavirus S1 glycoprotein)|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR043473|interpro:IPR043607|interpro:IPR043614	refseq:NP_001141.2|refseq:XP_011519775.1|ensembl:ENSG00000166825(gene)|ensembl:ENST00000300060(transcript)|ensembl:ENST00000559874(transcript)|ensembl:ENST00000560137(transcript)|ensembl:ENST00000679248(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001618"(virus receptor activity)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0007165"(signal transduction)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042277"(peptide binding)|go:"GO:0043171"(peptide catabolic process)|go:"GO:0070006"(metalloaminopeptidase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001930(Peptidase M1, membrane alanine aminopeptidase)|interpro:IPR014782(Peptidase M1, membrane alanine aminopeptidase, N-terminal)|interpro:IPR024571|interpro:IPR027268|interpro:IPR034016|interpro:IPR042097|rcsb pdb:4FYQ|rcsb pdb:4FYR|rcsb pdb:4FYS|rcsb pdb:4FYT|rcsb pdb:5LHD|rcsb pdb:6ATK|rcsb pdb:6U7E|rcsb pdb:6U7F|rcsb pdb:6U7G|rcsb pdb:6XWD|rcsb pdb:7AEW|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_005254949.1	-	-	-	figure legend:Supp. File 2|3d-resolution:2.35Å|3d-r-factors:Rwork - 0.179  Rfree - 0.218|comment:S protein uniprot accession was taken as Q1HVK9 from the given genbank accession ABB90523.1, however PDBe supports Q1HVK2 accession. On aligning both the sequences, no difference was observed on binding range 292-432, so Q1HVK9 was chosen|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/20	2020/03/26	rogid:9IAb3aeeybKMVW1ODMGx5VBBGOc11137	rogid:rKOeK87j6V1zOyRYGR7v2CHuZn09606	rigid:h0QNrDLiXC2z92znEyKFLb++jow	false	sufficient binding region:292-432	sufficient binding region:66-967	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15423	uniprotkb:P15423	intact:EBI-25474626|uniprotkb:P89342|uniprotkb:P89343|uniprotkb:P89344|uniprotkb:Q66174|uniprotkb:Q990M1|uniprotkb:Q990M2|uniprotkb:Q990M3|uniprotkb:Q990M4	intact:EBI-25474626|uniprotkb:P89342|uniprotkb:P89343|uniprotkb:P89344|uniprotkb:Q66174|uniprotkb:Q990M1|uniprotkb:Q990M2|uniprotkb:Q990M3|uniprotkb:Q990M4	psi-mi:spike_cvh22(display_long)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name)|uniprotkb:S(gene name)|psi-mi:S(display_short)	psi-mi:spike_cvh22(display_long)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name)|uniprotkb:S(gene name)|psi-mi:S(display_short)	psi-mi:"MI:0410"(3D electron microscopy)	Li et al. (2019)	pubmed:31650956|imex:IM-27809	taxid:11137(hcov-229e)|taxid:11137(Human coronavirus 229E)	taxid:11137(hcov-229e)|taxid:11137(Human coronavirus 229E)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25474657|pdbe:6u7h|emdb:EMD-20668|imex:IM-27809-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR044873|interpro:IPR044874|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|interpro:IPR043473|rcsb pdb:7CYC|rcsb pdb:7CYD|rcsb pdb:6U7H|refseq:NP_073551.1|rcsb pdb:5YL9|rcsb pdb:5ZHY|rcsb pdb:5ZUV|rcsb pdb:6ATK|interpro:IPR042552|interpro:IPR002551(Coronavirus S1 glycoprotein)|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR043607|interpro:IPR043614	interpro:IPR044873|interpro:IPR044874|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|interpro:IPR043473|rcsb pdb:7CYC|rcsb pdb:7CYD|rcsb pdb:6U7H|refseq:NP_073551.1|rcsb pdb:5YL9|rcsb pdb:5ZHY|rcsb pdb:5ZUV|rcsb pdb:6ATK|interpro:IPR042552|interpro:IPR002551(Coronavirus S1 glycoprotein)|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR043607|interpro:IPR043614	-	-	-	figure legend:Supplementary file 1|3d-resolution:3.1Å|comment:"The authors have used AAK32191.1 protein sequence, which maps to UniProt P15423 (>99% homology)"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293f)|taxid:9606(Homo sapiens HEK293F cell line)	-	2020/03/20	2020/03/26	rogid:xe6ZlVkcp8x2mQKwz34J2HOLSX811137	rogid:xe6ZlVkcp8x2mQKwz34J2HOLSX811137	rigid:JRm+BkHnhFBe6kTTQdN/5GqtoPY	false	his tag:c-c|mutation:871-872|sufficient binding region:17-1113	his tag:c-c|mutation:871-872|sufficient binding region:17-1113	3	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)