#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9BXV9	uniprotkb:Q14657	intact:EBI-6256593|ensembl:ENSP00000306320|ensembl:ENSP00000478863|uniprotkb:Q0D2N1|uniprotkb:Q0P6C4|uniprotkb:Q3B7W5	intact:EBI-1052105|uniprotkb:Q5HY39|uniprotkb:Q8IZ78|ensembl:ENSP00000349923	psi-mi:gon7_human(display_long)|uniprotkb:GON7(gene name)|psi-mi:GON7(display_short)|uniprotkb:C14orf142(orf name)	psi-mi:lage3_human(display_long)|uniprotkb:Protein ITBA2(gene name synonym)|uniprotkb:Protein ESO-3(gene name synonym)|uniprotkb:ITBA2(gene name synonym)|uniprotkb:LAGE3(gene name)|psi-mi:LAGE3(display_short)|uniprotkb:DXS9879E(gene name synonym)|uniprotkb:ESO3(gene name synonym)|uniprotkb:L antigen family member 3(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Arrondel et al. (2019)	pubmed:31481669|imex:IM-27727	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25431337|pdbe:6gwj|imex:IM-27727-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000170270(gene)|ensembl:ENSG00000275619(gene)|ensembl:ENST00000306954(transcript)|ensembl:ENST00000621279(transcript)|go:"GO:0000408"(EKC/KEOPS complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|interpro:IPR027893|rcsb pdb:6GWJ|refseq:NP_115879.2	refseq:NP_006005.2|ensembl:ENSG00000196976(gene)|ensembl:ENST00000357360(transcript)|go:"GO:0000408"(EKC/KEOPS complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008033"(tRNA processing)|go:"GO:0016604"(nuclear body)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070525"(tRNA threonylcarbamoyladenosine metabolic process)|interpro:IPR015419(Transcription factor Pcc1)|rcsb pdb:6GWJ|reactome:R-HSA-6782315	-	-	-	figure legend:Fig. 5C and D, Fig. S14 and Table S5|3d-resolution:1.95A resolution|3d-r-factors:"R work: 0.186   R free: 0.217"|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/02/19	2020/02/19	rogid:0VNjWOL8/4kDs/rbUhSgejc9blU9606	rogid:i85i7GnA4k4+zsftYKYMk+xWAFM9606	rigid:RJ2gzT+luihe4cQUR+dtzsugGGY	false	binding-associated region:?-?|his tag:?-?	binding-associated region:?-?|binding-associated region:?-?	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BXV9	uniprotkb:Q9NPF4	intact:EBI-6256593|ensembl:ENSP00000306320|ensembl:ENSP00000478863|uniprotkb:Q0D2N1|uniprotkb:Q0P6C4|uniprotkb:Q3B7W5	intact:EBI-1056510|uniprotkb:Q6IAC3|ensembl:ENSP00000206542	psi-mi:gon7_human(display_long)|uniprotkb:GON7(gene name)|psi-mi:GON7(display_short)|uniprotkb:C14orf142(orf name)	psi-mi:osgep_human(display_long)|uniprotkb:"t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEP"(gene name synonym)|uniprotkb:OSGEP(gene name)|psi-mi:OSGEP(display_short)|uniprotkb:GCPL1(gene name synonym)|uniprotkb:O-sialoglycoprotein endopeptidase(gene name synonym)|uniprotkb:tRNA threonylcarbamoyladenosine biosynthesis protein OSGEP(gene name synonym)|uniprotkb:N6-L-threonylcarbamoyladenine synthase(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Arrondel et al. (2019)	pubmed:31481669|imex:IM-27727	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25431337|pdbe:6gwj|imex:IM-27727-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000170270(gene)|ensembl:ENSG00000275619(gene)|ensembl:ENST00000306954(transcript)|ensembl:ENST00000621279(transcript)|go:"GO:0000408"(EKC/KEOPS complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|interpro:IPR027893|rcsb pdb:6GWJ|refseq:NP_115879.2	refseq:NP_060277.1|ensembl:ENSG00000092094(gene)|ensembl:ENST00000206542(transcript)|go:"GO:0000408"(EKC/KEOPS complex)|go:"GO:0002949"(tRNA threonylcarbamoyladenosine modification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0046872"(metal ion binding)|go:"GO:0061711"("N(6)-L-threonylcarbamoyladenine synthase activity")|interpro:IPR000905(Peptidase M22, glycoprotease)|interpro:IPR017860|interpro:IPR017861|interpro:IPR034680|interpro:IPR043129|mint:Q9NPF4|rcsb pdb:6GWJ|reactome:R-HSA-6782315	-	-	-	figure legend:Fig. 5C and D, Fig. S14 and Table S5|3d-resolution:1.95A resolution|3d-r-factors:"R work: 0.186   R free: 0.217"|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/02/19	2020/02/19	rogid:0VNjWOL8/4kDs/rbUhSgejc9blU9606	rogid:gdWaUekKJ7WFXfPlaleW9Dpmsi89606	rigid:RJ2gzT+luihe4cQUR+dtzsugGGY	false	binding-associated region:?-?|his tag:?-?	binding-associated region:?-?	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BXV9	uniprotkb:Q14657	intact:EBI-6256593|ensembl:ENSP00000306320|ensembl:ENSP00000478863|uniprotkb:Q0D2N1|uniprotkb:Q0P6C4|uniprotkb:Q3B7W5	intact:EBI-1052105|uniprotkb:Q5HY39|uniprotkb:Q8IZ78|ensembl:ENSP00000349923	psi-mi:gon7_human(display_long)|uniprotkb:GON7(gene name)|psi-mi:GON7(display_short)|uniprotkb:C14orf142(orf name)	psi-mi:lage3_human(display_long)|uniprotkb:Protein ITBA2(gene name synonym)|uniprotkb:Protein ESO-3(gene name synonym)|uniprotkb:ITBA2(gene name synonym)|uniprotkb:LAGE3(gene name)|psi-mi:LAGE3(display_short)|uniprotkb:DXS9879E(gene name synonym)|uniprotkb:ESO3(gene name synonym)|uniprotkb:L antigen family member 3(gene name synonym)	psi-mi:"MI:0826"(x ray scattering)	Arrondel et al. (2019)	pubmed:31481669|imex:IM-27727	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25431357|imex:IM-27727-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000170270(gene)|ensembl:ENSG00000275619(gene)|ensembl:ENST00000306954(transcript)|ensembl:ENST00000621279(transcript)|go:"GO:0000408"(EKC/KEOPS complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|interpro:IPR027893|rcsb pdb:6GWJ|refseq:NP_115879.2	refseq:NP_006005.2|ensembl:ENSG00000196976(gene)|ensembl:ENST00000357360(transcript)|go:"GO:0000408"(EKC/KEOPS complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008033"(tRNA processing)|go:"GO:0016604"(nuclear body)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070525"(tRNA threonylcarbamoyladenosine metabolic process)|interpro:IPR015419(Transcription factor Pcc1)|rcsb pdb:6GWJ|reactome:R-HSA-6782315	-	-	-	figure legend:Fig. 5A and B, Fig. S6B and D and Table S4|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/02/19	2020/02/19	rogid:0VNjWOL8/4kDs/rbUhSgejc9blU9606	rogid:i85i7GnA4k4+zsftYKYMk+xWAFM9606	rigid:RJ2gzT+luihe4cQUR+dtzsugGGY	false	his tag:?-?	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BXV9	uniprotkb:Q9NPF4	intact:EBI-6256593|ensembl:ENSP00000306320|ensembl:ENSP00000478863|uniprotkb:Q0D2N1|uniprotkb:Q0P6C4|uniprotkb:Q3B7W5	intact:EBI-1056510|uniprotkb:Q6IAC3|ensembl:ENSP00000206542	psi-mi:gon7_human(display_long)|uniprotkb:GON7(gene name)|psi-mi:GON7(display_short)|uniprotkb:C14orf142(orf name)	psi-mi:osgep_human(display_long)|uniprotkb:"t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEP"(gene name synonym)|uniprotkb:OSGEP(gene name)|psi-mi:OSGEP(display_short)|uniprotkb:GCPL1(gene name synonym)|uniprotkb:O-sialoglycoprotein endopeptidase(gene name synonym)|uniprotkb:tRNA threonylcarbamoyladenosine biosynthesis protein OSGEP(gene name synonym)|uniprotkb:N6-L-threonylcarbamoyladenine synthase(gene name synonym)	psi-mi:"MI:0826"(x ray scattering)	Arrondel et al. (2019)	pubmed:31481669|imex:IM-27727	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25431357|imex:IM-27727-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000170270(gene)|ensembl:ENSG00000275619(gene)|ensembl:ENST00000306954(transcript)|ensembl:ENST00000621279(transcript)|go:"GO:0000408"(EKC/KEOPS complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|interpro:IPR027893|rcsb pdb:6GWJ|refseq:NP_115879.2	refseq:NP_060277.1|ensembl:ENSG00000092094(gene)|ensembl:ENST00000206542(transcript)|go:"GO:0000408"(EKC/KEOPS complex)|go:"GO:0002949"(tRNA threonylcarbamoyladenosine modification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0046872"(metal ion binding)|go:"GO:0061711"("N(6)-L-threonylcarbamoyladenine synthase activity")|interpro:IPR000905(Peptidase M22, glycoprotease)|interpro:IPR017860|interpro:IPR017861|interpro:IPR034680|interpro:IPR043129|mint:Q9NPF4|rcsb pdb:6GWJ|reactome:R-HSA-6782315	-	-	-	figure legend:Fig. 5A and B, Fig. S6B and D and Table S4|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/02/19	2020/02/19	rogid:0VNjWOL8/4kDs/rbUhSgejc9blU9606	rogid:gdWaUekKJ7WFXfPlaleW9Dpmsi89606	rigid:RJ2gzT+luihe4cQUR+dtzsugGGY	false	his tag:?-?	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BXV9	uniprotkb:Q14657	intact:EBI-6256593|ensembl:ENSP00000306320|ensembl:ENSP00000478863|uniprotkb:Q0D2N1|uniprotkb:Q0P6C4|uniprotkb:Q3B7W5	intact:EBI-1052105|uniprotkb:Q5HY39|uniprotkb:Q8IZ78|ensembl:ENSP00000349923	psi-mi:gon7_human(display_long)|uniprotkb:GON7(gene name)|psi-mi:GON7(display_short)|uniprotkb:C14orf142(orf name)	psi-mi:lage3_human(display_long)|uniprotkb:Protein ITBA2(gene name synonym)|uniprotkb:Protein ESO-3(gene name synonym)|uniprotkb:ITBA2(gene name synonym)|uniprotkb:LAGE3(gene name)|psi-mi:LAGE3(display_short)|uniprotkb:DXS9879E(gene name synonym)|uniprotkb:ESO3(gene name synonym)|uniprotkb:L antigen family member 3(gene name synonym)	psi-mi:"MI:0826"(x ray scattering)	Arrondel et al. (2019)	pubmed:31481669|imex:IM-27727	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25431365|imex:IM-27727-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000170270(gene)|ensembl:ENSG00000275619(gene)|ensembl:ENST00000306954(transcript)|ensembl:ENST00000621279(transcript)|go:"GO:0000408"(EKC/KEOPS complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|interpro:IPR027893|rcsb pdb:6GWJ|refseq:NP_115879.2	refseq:NP_006005.2|ensembl:ENSG00000196976(gene)|ensembl:ENST00000357360(transcript)|go:"GO:0000408"(EKC/KEOPS complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008033"(tRNA processing)|go:"GO:0016604"(nuclear body)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070525"(tRNA threonylcarbamoyladenosine metabolic process)|interpro:IPR015419(Transcription factor Pcc1)|rcsb pdb:6GWJ|reactome:R-HSA-6782315	-	-	-	figure legend:Fig. 5A and B, Fig. S6B and D and Table S4|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/02/19	2020/02/21	rogid:0VNjWOL8/4kDs/rbUhSgejc9blU9606	rogid:i85i7GnA4k4+zsftYKYMk+xWAFM9606	rigid:3y3ZESJngBLKvBIPRuF9StT+t24	false	his tag:?-?	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BXV9	uniprotkb:Q14657	intact:EBI-6256593|ensembl:ENSP00000306320|ensembl:ENSP00000478863|uniprotkb:Q0D2N1|uniprotkb:Q0P6C4|uniprotkb:Q3B7W5	intact:EBI-1052105|uniprotkb:Q5HY39|uniprotkb:Q8IZ78|ensembl:ENSP00000349923	psi-mi:gon7_human(display_long)|uniprotkb:GON7(gene name)|psi-mi:GON7(display_short)|uniprotkb:C14orf142(orf name)	psi-mi:lage3_human(display_long)|uniprotkb:Protein ITBA2(gene name synonym)|uniprotkb:Protein ESO-3(gene name synonym)|uniprotkb:ITBA2(gene name synonym)|uniprotkb:LAGE3(gene name)|psi-mi:LAGE3(display_short)|uniprotkb:DXS9879E(gene name synonym)|uniprotkb:ESO3(gene name synonym)|uniprotkb:L antigen family member 3(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Arrondel et al. (2019)	pubmed:31481669|imex:IM-27727	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25431377|imex:IM-27727-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000170270(gene)|ensembl:ENSG00000275619(gene)|ensembl:ENST00000306954(transcript)|ensembl:ENST00000621279(transcript)|go:"GO:0000408"(EKC/KEOPS complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|interpro:IPR027893|rcsb pdb:6GWJ|refseq:NP_115879.2	refseq:NP_006005.2|ensembl:ENSG00000196976(gene)|ensembl:ENST00000357360(transcript)|go:"GO:0000408"(EKC/KEOPS complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008033"(tRNA processing)|go:"GO:0016604"(nuclear body)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070525"(tRNA threonylcarbamoyladenosine metabolic process)|interpro:IPR015419(Transcription factor Pcc1)|rcsb pdb:6GWJ|reactome:R-HSA-6782315	-	-	-	figure legend:Table S9 and Fig. S13B|comment:C3 fraction|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/02/19	2020/02/20	rogid:0VNjWOL8/4kDs/rbUhSgejc9blU9606	rogid:i85i7GnA4k4+zsftYKYMk+xWAFM9606	rigid:jhJfupTkZ25LEydRTwnDAv9BEzQ	false	his tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BXV9	uniprotkb:Q9NPF4	intact:EBI-6256593|ensembl:ENSP00000306320|ensembl:ENSP00000478863|uniprotkb:Q0D2N1|uniprotkb:Q0P6C4|uniprotkb:Q3B7W5	intact:EBI-1056510|uniprotkb:Q6IAC3|ensembl:ENSP00000206542	psi-mi:gon7_human(display_long)|uniprotkb:GON7(gene name)|psi-mi:GON7(display_short)|uniprotkb:C14orf142(orf name)	psi-mi:osgep_human(display_long)|uniprotkb:"t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEP"(gene name synonym)|uniprotkb:OSGEP(gene name)|psi-mi:OSGEP(display_short)|uniprotkb:GCPL1(gene name synonym)|uniprotkb:O-sialoglycoprotein endopeptidase(gene name synonym)|uniprotkb:tRNA threonylcarbamoyladenosine biosynthesis protein OSGEP(gene name synonym)|uniprotkb:N6-L-threonylcarbamoyladenine synthase(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Arrondel et al. (2019)	pubmed:31481669|imex:IM-27727	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25431377|imex:IM-27727-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000170270(gene)|ensembl:ENSG00000275619(gene)|ensembl:ENST00000306954(transcript)|ensembl:ENST00000621279(transcript)|go:"GO:0000408"(EKC/KEOPS complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|interpro:IPR027893|rcsb pdb:6GWJ|refseq:NP_115879.2	refseq:NP_060277.1|ensembl:ENSG00000092094(gene)|ensembl:ENST00000206542(transcript)|go:"GO:0000408"(EKC/KEOPS complex)|go:"GO:0002949"(tRNA threonylcarbamoyladenosine modification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0046872"(metal ion binding)|go:"GO:0061711"("N(6)-L-threonylcarbamoyladenine synthase activity")|interpro:IPR000905(Peptidase M22, glycoprotease)|interpro:IPR017860|interpro:IPR017861|interpro:IPR034680|interpro:IPR043129|mint:Q9NPF4|rcsb pdb:6GWJ|reactome:R-HSA-6782315	-	-	-	figure legend:Table S9 and Fig. S13B|comment:C3 fraction|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/02/19	2020/02/20	rogid:0VNjWOL8/4kDs/rbUhSgejc9blU9606	rogid:gdWaUekKJ7WFXfPlaleW9Dpmsi89606	rigid:jhJfupTkZ25LEydRTwnDAv9BEzQ	false	his tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BXV9	uniprotkb:Q96S44	intact:EBI-6256593|ensembl:ENSP00000306320|ensembl:ENSP00000478863|uniprotkb:Q0D2N1|uniprotkb:Q0P6C4|uniprotkb:Q3B7W5	intact:EBI-739588|uniprotkb:Q3T977|uniprotkb:Q5JZ01|uniprotkb:Q6NZ60|uniprotkb:Q96FM7|uniprotkb:Q9NQE6|uniprotkb:B3KU44|ensembl:ENSP00000361186	psi-mi:gon7_human(display_long)|uniprotkb:GON7(gene name)|psi-mi:GON7(display_short)|uniprotkb:C14orf142(orf name)	psi-mi:prpk_human(display_long)|uniprotkb:TP53-regulating kinase(gene name synonym)|uniprotkb:TP53RK(gene name)|psi-mi:TP53RK(display_short)|uniprotkb:C20orf64(gene name synonym)|uniprotkb:PRPK(gene name synonym)|uniprotkb:p53-related protein kinase(gene name synonym)|uniprotkb:Nori-2(gene name synonym)|uniprotkb:Atypical serine/threonine protein kinase TP53RK(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Arrondel et al. (2019)	pubmed:31481669|imex:IM-27727	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25431377|imex:IM-27727-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000170270(gene)|ensembl:ENSG00000275619(gene)|ensembl:ENST00000306954(transcript)|ensembl:ENST00000621279(transcript)|go:"GO:0000408"(EKC/KEOPS complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|interpro:IPR027893|rcsb pdb:6GWJ|refseq:NP_115879.2	refseq:NP_291028.3|ensembl:ENSG00000172315(gene)|ensembl:ENST00000372114(transcript)|go:"GO:0000408"(EKC/KEOPS complex)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008033"(tRNA processing)|go:"GO:0016787"(hydrolase activity)|go:"GO:0070525"(tRNA threonylcarbamoyladenosine metabolic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022495|rcsb pdb:6WQX|reactome:R-HSA-6782315|reactome:R-HSA-6804756	-	-	-	figure legend:Table S9 and Fig. S13B|comment:C3 fraction|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/02/19	2020/02/20	rogid:0VNjWOL8/4kDs/rbUhSgejc9blU9606	rogid:sgh5tCNgPpL4E4SmEQhLz6qci109606	rigid:jhJfupTkZ25LEydRTwnDAv9BEzQ	false	his tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BXV9	uniprotkb:Q9Y3C4	intact:EBI-6256593|ensembl:ENSP00000306320|ensembl:ENSP00000478863|uniprotkb:Q0D2N1|uniprotkb:Q0P6C4|uniprotkb:Q3B7W5	intact:EBI-750123|uniprotkb:D6W5H6|uniprotkb:Q8IWR6|uniprotkb:Q8IWR7|uniprotkb:Q9H3K4|ensembl:ENSP00000272424	psi-mi:gon7_human(display_long)|uniprotkb:GON7(gene name)|psi-mi:GON7(display_short)|uniprotkb:C14orf142(orf name)	psi-mi:tprkb_human(display_long)|uniprotkb:PRPK-binding protein(gene name synonym)|uniprotkb:TPRKB(gene name)|psi-mi:TPRKB(display_short)|uniprotkb:TP53RK-binding protein(gene name synonym)|uniprotkb:CGI-121(orf name)|uniprotkb:My019(orf name)	psi-mi:"MI:0071"(molecular sieving)	Arrondel et al. (2019)	pubmed:31481669|imex:IM-27727	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25431377|imex:IM-27727-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000170270(gene)|ensembl:ENSG00000275619(gene)|ensembl:ENST00000306954(transcript)|ensembl:ENST00000621279(transcript)|go:"GO:0000408"(EKC/KEOPS complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|interpro:IPR027893|rcsb pdb:6GWJ|refseq:NP_115879.2	refseq:XP_011531179.1|refseq:XP_011531180.1|refseq:NP_057142.1|refseq:XP_006712090.1|refseq:NP_001317315.1|refseq:NP_001317316.1|refseq:NP_001317317.1|refseq:NP_001317318.1|refseq:NP_001317320.1|refseq:NP_001317321.1|refseq:XP_016859721.1|refseq:XP_016859722.1|refseq:XP_016859723.1|ensembl:ENSG00000144034(gene)|ensembl:ENST00000272424(transcript)|go:"GO:0000408"(EKC/KEOPS complex)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0002949"(tRNA threonylcarbamoyladenosine modification)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0019901"(protein kinase binding)|interpro:IPR013926(Kinase binding protein CGI-121)|interpro:IPR036504|rcsb pdb:3ENP|rcsb pdb:6WQX|reactome:R-HSA-6782315	-	-	-	figure legend:Table S9 and Fig. S13B|comment:C3 fraction|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/02/19	2020/02/20	rogid:0VNjWOL8/4kDs/rbUhSgejc9blU9606	rogid:hsboCuMYBT3FzLom262TDGm5lOQ9606	rigid:jhJfupTkZ25LEydRTwnDAv9BEzQ	false	his tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q14657	uniprotkb:Q9BXV9	intact:EBI-1052105|uniprotkb:Q5HY39|uniprotkb:Q8IZ78|ensembl:ENSP00000349923	intact:EBI-6256593|ensembl:ENSP00000306320|ensembl:ENSP00000478863|uniprotkb:Q0D2N1|uniprotkb:Q0P6C4|uniprotkb:Q3B7W5	psi-mi:lage3_human(display_long)|uniprotkb:Protein ITBA2(gene name synonym)|uniprotkb:Protein ESO-3(gene name synonym)|uniprotkb:ITBA2(gene name synonym)|uniprotkb:LAGE3(gene name)|psi-mi:LAGE3(display_short)|uniprotkb:DXS9879E(gene name synonym)|uniprotkb:ESO3(gene name synonym)|uniprotkb:L antigen family member 3(gene name synonym)	psi-mi:gon7_human(display_long)|uniprotkb:GON7(gene name)|psi-mi:GON7(display_short)|uniprotkb:C14orf142(orf name)	psi-mi:"MI:0071"(molecular sieving)	Arrondel et al. (2019)	pubmed:31481669|imex:IM-27727	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25431425|imex:IM-27727-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006005.2|ensembl:ENSG00000196976(gene)|ensembl:ENST00000357360(transcript)|go:"GO:0000408"(EKC/KEOPS complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008033"(tRNA processing)|go:"GO:0016604"(nuclear body)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070525"(tRNA threonylcarbamoyladenosine metabolic process)|interpro:IPR015419(Transcription factor Pcc1)|rcsb pdb:6GWJ|reactome:R-HSA-6782315	ensembl:ENSG00000170270(gene)|ensembl:ENSG00000275619(gene)|ensembl:ENST00000306954(transcript)|ensembl:ENST00000621279(transcript)|go:"GO:0000408"(EKC/KEOPS complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|interpro:IPR027893|rcsb pdb:6GWJ|refseq:NP_115879.2	-	-	-	figure legend:Fig. S12|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/02/19	2020/02/20	rogid:i85i7GnA4k4+zsftYKYMk+xWAFM9606	rogid:0VNjWOL8/4kDs/rbUhSgejc9blU9606	rigid:3y3ZESJngBLKvBIPRuF9StT+t24	false	-	his tag:?-?	-	-	psi-mi:"MI:0815"(confirmation by molecular weight)	psi-mi:"MI:0815"(confirmation by molecular weight)
uniprotkb:Q9BXV9	uniprotkb:Q14657	intact:EBI-6256593|ensembl:ENSP00000306320|ensembl:ENSP00000478863|uniprotkb:Q0D2N1|uniprotkb:Q0P6C4|uniprotkb:Q3B7W5	intact:EBI-1052105|uniprotkb:Q5HY39|uniprotkb:Q8IZ78|ensembl:ENSP00000349923	psi-mi:gon7_human(display_long)|uniprotkb:GON7(gene name)|psi-mi:GON7(display_short)|uniprotkb:C14orf142(orf name)	psi-mi:lage3_human(display_long)|uniprotkb:Protein ITBA2(gene name synonym)|uniprotkb:Protein ESO-3(gene name synonym)|uniprotkb:ITBA2(gene name synonym)|uniprotkb:LAGE3(gene name)|psi-mi:LAGE3(display_short)|uniprotkb:DXS9879E(gene name synonym)|uniprotkb:ESO3(gene name synonym)|uniprotkb:L antigen family member 3(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Arrondel et al. (2019)	pubmed:31481669|imex:IM-27727	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25431648|imex:IM-27727-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000170270(gene)|ensembl:ENSG00000275619(gene)|ensembl:ENST00000306954(transcript)|ensembl:ENST00000621279(transcript)|go:"GO:0000408"(EKC/KEOPS complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|interpro:IPR027893|rcsb pdb:6GWJ|refseq:NP_115879.2	refseq:NP_006005.2|ensembl:ENSG00000196976(gene)|ensembl:ENST00000357360(transcript)|go:"GO:0000408"(EKC/KEOPS complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008033"(tRNA processing)|go:"GO:0016604"(nuclear body)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070525"(tRNA threonylcarbamoyladenosine metabolic process)|interpro:IPR015419(Transcription factor Pcc1)|rcsb pdb:6GWJ|reactome:R-HSA-6782315	-	-	-	figure legend:Fig. S13B|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/02/19	2020/02/20	rogid:0VNjWOL8/4kDs/rbUhSgejc9blU9606	rogid:i85i7GnA4k4+zsftYKYMk+xWAFM9606	rigid:RJ2gzT+luihe4cQUR+dtzsugGGY	false	his tag:?-?	-	-	-	psi-mi:"MI:0815"(confirmation by molecular weight)	psi-mi:"MI:0815"(confirmation by molecular weight)
uniprotkb:Q9BXV9	uniprotkb:Q9NPF4	intact:EBI-6256593|ensembl:ENSP00000306320|ensembl:ENSP00000478863|uniprotkb:Q0D2N1|uniprotkb:Q0P6C4|uniprotkb:Q3B7W5	intact:EBI-1056510|uniprotkb:Q6IAC3|ensembl:ENSP00000206542	psi-mi:gon7_human(display_long)|uniprotkb:GON7(gene name)|psi-mi:GON7(display_short)|uniprotkb:C14orf142(orf name)	psi-mi:osgep_human(display_long)|uniprotkb:"t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEP"(gene name synonym)|uniprotkb:OSGEP(gene name)|psi-mi:OSGEP(display_short)|uniprotkb:GCPL1(gene name synonym)|uniprotkb:O-sialoglycoprotein endopeptidase(gene name synonym)|uniprotkb:tRNA threonylcarbamoyladenosine biosynthesis protein OSGEP(gene name synonym)|uniprotkb:N6-L-threonylcarbamoyladenine synthase(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Arrondel et al. (2019)	pubmed:31481669|imex:IM-27727	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25431648|imex:IM-27727-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000170270(gene)|ensembl:ENSG00000275619(gene)|ensembl:ENST00000306954(transcript)|ensembl:ENST00000621279(transcript)|go:"GO:0000408"(EKC/KEOPS complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|interpro:IPR027893|rcsb pdb:6GWJ|refseq:NP_115879.2	refseq:NP_060277.1|ensembl:ENSG00000092094(gene)|ensembl:ENST00000206542(transcript)|go:"GO:0000408"(EKC/KEOPS complex)|go:"GO:0002949"(tRNA threonylcarbamoyladenosine modification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0046872"(metal ion binding)|go:"GO:0061711"("N(6)-L-threonylcarbamoyladenine synthase activity")|interpro:IPR000905(Peptidase M22, glycoprotease)|interpro:IPR017860|interpro:IPR017861|interpro:IPR034680|interpro:IPR043129|mint:Q9NPF4|rcsb pdb:6GWJ|reactome:R-HSA-6782315	-	-	-	figure legend:Fig. S13B|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/02/19	2020/02/20	rogid:0VNjWOL8/4kDs/rbUhSgejc9blU9606	rogid:gdWaUekKJ7WFXfPlaleW9Dpmsi89606	rigid:RJ2gzT+luihe4cQUR+dtzsugGGY	false	his tag:?-?	-	-	-	psi-mi:"MI:0815"(confirmation by molecular weight)	psi-mi:"MI:0815"(confirmation by molecular weight)
uniprotkb:Q14657	uniprotkb:Q9BXV9	intact:EBI-1052105|uniprotkb:Q5HY39|uniprotkb:Q8IZ78|ensembl:ENSP00000349923	intact:EBI-6256593|ensembl:ENSP00000306320|ensembl:ENSP00000478863|uniprotkb:Q0D2N1|uniprotkb:Q0P6C4|uniprotkb:Q3B7W5	psi-mi:lage3_human(display_long)|uniprotkb:Protein ITBA2(gene name synonym)|uniprotkb:Protein ESO-3(gene name synonym)|uniprotkb:ITBA2(gene name synonym)|uniprotkb:LAGE3(gene name)|psi-mi:LAGE3(display_short)|uniprotkb:DXS9879E(gene name synonym)|uniprotkb:ESO3(gene name synonym)|uniprotkb:L antigen family member 3(gene name synonym)	psi-mi:gon7_human(display_long)|uniprotkb:GON7(gene name)|psi-mi:GON7(display_short)|uniprotkb:C14orf142(orf name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Arrondel et al. (2019)	pubmed:31481669|imex:IM-27727	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25431679|imex:IM-27727-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006005.2|ensembl:ENSG00000196976(gene)|ensembl:ENST00000357360(transcript)|go:"GO:0000408"(EKC/KEOPS complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008033"(tRNA processing)|go:"GO:0016604"(nuclear body)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070525"(tRNA threonylcarbamoyladenosine metabolic process)|interpro:IPR015419(Transcription factor Pcc1)|rcsb pdb:6GWJ|reactome:R-HSA-6782315	ensembl:ENSG00000170270(gene)|ensembl:ENSG00000275619(gene)|ensembl:ENST00000306954(transcript)|ensembl:ENST00000621279(transcript)|go:"GO:0000408"(EKC/KEOPS complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|interpro:IPR027893|rcsb pdb:6GWJ|refseq:NP_115879.2	-	-	-	figure legend:Fig. S6A|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/02/19	2020/02/20	rogid:i85i7GnA4k4+zsftYKYMk+xWAFM9606	rogid:0VNjWOL8/4kDs/rbUhSgejc9blU9606	rigid:3y3ZESJngBLKvBIPRuF9StT+t24	false	his tag:?-?	his tag:?-?|15n label:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BXV9	uniprotkb:Q96S44	intact:EBI-6256593|ensembl:ENSP00000306320|ensembl:ENSP00000478863|uniprotkb:Q0D2N1|uniprotkb:Q0P6C4|uniprotkb:Q3B7W5	intact:EBI-739588|uniprotkb:Q3T977|uniprotkb:Q5JZ01|uniprotkb:Q6NZ60|uniprotkb:Q96FM7|uniprotkb:Q9NQE6|uniprotkb:B3KU44|ensembl:ENSP00000361186	psi-mi:gon7_human(display_long)|uniprotkb:GON7(gene name)|psi-mi:GON7(display_short)|uniprotkb:C14orf142(orf name)	psi-mi:prpk_human(display_long)|uniprotkb:TP53-regulating kinase(gene name synonym)|uniprotkb:TP53RK(gene name)|psi-mi:TP53RK(display_short)|uniprotkb:C20orf64(gene name synonym)|uniprotkb:PRPK(gene name synonym)|uniprotkb:p53-related protein kinase(gene name synonym)|uniprotkb:Nori-2(gene name synonym)|uniprotkb:Atypical serine/threonine protein kinase TP53RK(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Arrondel et al. (2019)	pubmed:31481669|imex:IM-27727	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25431718|imex:IM-27727-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000170270(gene)|ensembl:ENSG00000275619(gene)|ensembl:ENST00000306954(transcript)|ensembl:ENST00000621279(transcript)|go:"GO:0000408"(EKC/KEOPS complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|interpro:IPR027893|rcsb pdb:6GWJ|refseq:NP_115879.2	refseq:NP_291028.3|ensembl:ENSG00000172315(gene)|ensembl:ENST00000372114(transcript)|go:"GO:0000408"(EKC/KEOPS complex)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008033"(tRNA processing)|go:"GO:0016787"(hydrolase activity)|go:"GO:0070525"(tRNA threonylcarbamoyladenosine metabolic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022495|rcsb pdb:6WQX|reactome:R-HSA-6782315|reactome:R-HSA-6804756	-	-	-	figure legend:Fig. S8A|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-podocyte)|taxid:9606(human podocyte)	-	2020/02/19	2020/02/20	rogid:0VNjWOL8/4kDs/rbUhSgejc9blU9606	rogid:sgh5tCNgPpL4E4SmEQhLz6qci109606	rigid:jhJfupTkZ25LEydRTwnDAv9BEzQ	false	ha tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BXV9	uniprotkb:Q9Y3C4	intact:EBI-6256593|ensembl:ENSP00000306320|ensembl:ENSP00000478863|uniprotkb:Q0D2N1|uniprotkb:Q0P6C4|uniprotkb:Q3B7W5	intact:EBI-750123|uniprotkb:D6W5H6|uniprotkb:Q8IWR6|uniprotkb:Q8IWR7|uniprotkb:Q9H3K4|ensembl:ENSP00000272424	psi-mi:gon7_human(display_long)|uniprotkb:GON7(gene name)|psi-mi:GON7(display_short)|uniprotkb:C14orf142(orf name)	psi-mi:tprkb_human(display_long)|uniprotkb:PRPK-binding protein(gene name synonym)|uniprotkb:TPRKB(gene name)|psi-mi:TPRKB(display_short)|uniprotkb:TP53RK-binding protein(gene name synonym)|uniprotkb:CGI-121(orf name)|uniprotkb:My019(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Arrondel et al. (2019)	pubmed:31481669|imex:IM-27727	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25431718|imex:IM-27727-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000170270(gene)|ensembl:ENSG00000275619(gene)|ensembl:ENST00000306954(transcript)|ensembl:ENST00000621279(transcript)|go:"GO:0000408"(EKC/KEOPS complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|interpro:IPR027893|rcsb pdb:6GWJ|refseq:NP_115879.2	refseq:XP_011531179.1|refseq:XP_011531180.1|refseq:NP_057142.1|refseq:XP_006712090.1|refseq:NP_001317315.1|refseq:NP_001317316.1|refseq:NP_001317317.1|refseq:NP_001317318.1|refseq:NP_001317320.1|refseq:NP_001317321.1|refseq:XP_016859721.1|refseq:XP_016859722.1|refseq:XP_016859723.1|ensembl:ENSG00000144034(gene)|ensembl:ENST00000272424(transcript)|go:"GO:0000408"(EKC/KEOPS complex)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0002949"(tRNA threonylcarbamoyladenosine modification)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0019901"(protein kinase binding)|interpro:IPR013926(Kinase binding protein CGI-121)|interpro:IPR036504|rcsb pdb:3ENP|rcsb pdb:6WQX|reactome:R-HSA-6782315	-	-	-	figure legend:Fig. S8A|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-podocyte)|taxid:9606(human podocyte)	-	2020/02/19	2020/02/20	rogid:0VNjWOL8/4kDs/rbUhSgejc9blU9606	rogid:hsboCuMYBT3FzLom262TDGm5lOQ9606	rigid:jhJfupTkZ25LEydRTwnDAv9BEzQ	false	ha tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BXV9	uniprotkb:Q14657	intact:EBI-6256593|ensembl:ENSP00000306320|ensembl:ENSP00000478863|uniprotkb:Q0D2N1|uniprotkb:Q0P6C4|uniprotkb:Q3B7W5	intact:EBI-1052105|uniprotkb:Q5HY39|uniprotkb:Q8IZ78|ensembl:ENSP00000349923	psi-mi:gon7_human(display_long)|uniprotkb:GON7(gene name)|psi-mi:GON7(display_short)|uniprotkb:C14orf142(orf name)	psi-mi:lage3_human(display_long)|uniprotkb:Protein ITBA2(gene name synonym)|uniprotkb:Protein ESO-3(gene name synonym)|uniprotkb:ITBA2(gene name synonym)|uniprotkb:LAGE3(gene name)|psi-mi:LAGE3(display_short)|uniprotkb:DXS9879E(gene name synonym)|uniprotkb:ESO3(gene name synonym)|uniprotkb:L antigen family member 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Arrondel et al. (2019)	pubmed:31481669|imex:IM-27727	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25431718|imex:IM-27727-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000170270(gene)|ensembl:ENSG00000275619(gene)|ensembl:ENST00000306954(transcript)|ensembl:ENST00000621279(transcript)|go:"GO:0000408"(EKC/KEOPS complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|interpro:IPR027893|rcsb pdb:6GWJ|refseq:NP_115879.2	refseq:NP_006005.2|ensembl:ENSG00000196976(gene)|ensembl:ENST00000357360(transcript)|go:"GO:0000408"(EKC/KEOPS complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008033"(tRNA processing)|go:"GO:0016604"(nuclear body)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070525"(tRNA threonylcarbamoyladenosine metabolic process)|interpro:IPR015419(Transcription factor Pcc1)|rcsb pdb:6GWJ|reactome:R-HSA-6782315	-	-	-	figure legend:Fig. S8A|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-podocyte)|taxid:9606(human podocyte)	-	2020/02/19	2020/02/20	rogid:0VNjWOL8/4kDs/rbUhSgejc9blU9606	rogid:i85i7GnA4k4+zsftYKYMk+xWAFM9606	rigid:jhJfupTkZ25LEydRTwnDAv9BEzQ	false	ha tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BXV9	uniprotkb:Q9NPF4	intact:EBI-6256593|ensembl:ENSP00000306320|ensembl:ENSP00000478863|uniprotkb:Q0D2N1|uniprotkb:Q0P6C4|uniprotkb:Q3B7W5	intact:EBI-1056510|uniprotkb:Q6IAC3|ensembl:ENSP00000206542	psi-mi:gon7_human(display_long)|uniprotkb:GON7(gene name)|psi-mi:GON7(display_short)|uniprotkb:C14orf142(orf name)	psi-mi:osgep_human(display_long)|uniprotkb:"t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEP"(gene name synonym)|uniprotkb:OSGEP(gene name)|psi-mi:OSGEP(display_short)|uniprotkb:GCPL1(gene name synonym)|uniprotkb:O-sialoglycoprotein endopeptidase(gene name synonym)|uniprotkb:tRNA threonylcarbamoyladenosine biosynthesis protein OSGEP(gene name synonym)|uniprotkb:N6-L-threonylcarbamoyladenine synthase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Arrondel et al. (2019)	pubmed:31481669|imex:IM-27727	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25431718|imex:IM-27727-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000170270(gene)|ensembl:ENSG00000275619(gene)|ensembl:ENST00000306954(transcript)|ensembl:ENST00000621279(transcript)|go:"GO:0000408"(EKC/KEOPS complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|interpro:IPR027893|rcsb pdb:6GWJ|refseq:NP_115879.2	refseq:NP_060277.1|ensembl:ENSG00000092094(gene)|ensembl:ENST00000206542(transcript)|go:"GO:0000408"(EKC/KEOPS complex)|go:"GO:0002949"(tRNA threonylcarbamoyladenosine modification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0046872"(metal ion binding)|go:"GO:0061711"("N(6)-L-threonylcarbamoyladenine synthase activity")|interpro:IPR000905(Peptidase M22, glycoprotease)|interpro:IPR017860|interpro:IPR017861|interpro:IPR034680|interpro:IPR043129|mint:Q9NPF4|rcsb pdb:6GWJ|reactome:R-HSA-6782315	-	-	-	figure legend:Fig. S8A|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-podocyte)|taxid:9606(human podocyte)	-	2020/02/19	2020/02/20	rogid:0VNjWOL8/4kDs/rbUhSgejc9blU9606	rogid:gdWaUekKJ7WFXfPlaleW9Dpmsi89606	rigid:jhJfupTkZ25LEydRTwnDAv9BEzQ	false	ha tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BXV9	uniprotkb:Q14657	intact:EBI-6256593|ensembl:ENSP00000306320|ensembl:ENSP00000478863|uniprotkb:Q0D2N1|uniprotkb:Q0P6C4|uniprotkb:Q3B7W5	intact:EBI-1052105|uniprotkb:Q5HY39|uniprotkb:Q8IZ78|ensembl:ENSP00000349923	psi-mi:gon7_human(display_long)|uniprotkb:GON7(gene name)|psi-mi:GON7(display_short)|uniprotkb:C14orf142(orf name)	psi-mi:lage3_human(display_long)|uniprotkb:Protein ITBA2(gene name synonym)|uniprotkb:Protein ESO-3(gene name synonym)|uniprotkb:ITBA2(gene name synonym)|uniprotkb:LAGE3(gene name)|psi-mi:LAGE3(display_short)|uniprotkb:DXS9879E(gene name synonym)|uniprotkb:ESO3(gene name synonym)|uniprotkb:L antigen family member 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Arrondel et al. (2019)	pubmed:31481669|imex:IM-27727	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25431737|imex:IM-27727-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000170270(gene)|ensembl:ENSG00000275619(gene)|ensembl:ENST00000306954(transcript)|ensembl:ENST00000621279(transcript)|go:"GO:0000408"(EKC/KEOPS complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|interpro:IPR027893|rcsb pdb:6GWJ|refseq:NP_115879.2	refseq:NP_006005.2|ensembl:ENSG00000196976(gene)|ensembl:ENST00000357360(transcript)|go:"GO:0000408"(EKC/KEOPS complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008033"(tRNA processing)|go:"GO:0016604"(nuclear body)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070525"(tRNA threonylcarbamoyladenosine metabolic process)|interpro:IPR015419(Transcription factor Pcc1)|rcsb pdb:6GWJ|reactome:R-HSA-6782315	-	-	-	figure legend:Fig. S8B|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/02/19	2020/02/20	rogid:0VNjWOL8/4kDs/rbUhSgejc9blU9606	rogid:i85i7GnA4k4+zsftYKYMk+xWAFM9606	rigid:3y3ZESJngBLKvBIPRuF9StT+t24	false	ha tag:?-?	v5 tag:?-?|mutation with no effect:106-106(rs1557211306)|mutation with no effect:137-137(rs1557211209)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BXV9	uniprotkb:Q14657	intact:EBI-6256593|ensembl:ENSP00000306320|ensembl:ENSP00000478863|uniprotkb:Q0D2N1|uniprotkb:Q0P6C4|uniprotkb:Q3B7W5	intact:EBI-1052105|uniprotkb:Q5HY39|uniprotkb:Q8IZ78|ensembl:ENSP00000349923	psi-mi:gon7_human(display_long)|uniprotkb:GON7(gene name)|psi-mi:GON7(display_short)|uniprotkb:C14orf142(orf name)	psi-mi:lage3_human(display_long)|uniprotkb:Protein ITBA2(gene name synonym)|uniprotkb:Protein ESO-3(gene name synonym)|uniprotkb:ITBA2(gene name synonym)|uniprotkb:LAGE3(gene name)|psi-mi:LAGE3(display_short)|uniprotkb:DXS9879E(gene name synonym)|uniprotkb:ESO3(gene name synonym)|uniprotkb:L antigen family member 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Arrondel et al. (2019)	pubmed:31481669|imex:IM-27727	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25431755|imex:IM-27727-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000170270(gene)|ensembl:ENSG00000275619(gene)|ensembl:ENST00000306954(transcript)|ensembl:ENST00000621279(transcript)|go:"GO:0000408"(EKC/KEOPS complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|interpro:IPR027893|rcsb pdb:6GWJ|refseq:NP_115879.2	refseq:NP_006005.2|ensembl:ENSG00000196976(gene)|ensembl:ENST00000357360(transcript)|go:"GO:0000408"(EKC/KEOPS complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008033"(tRNA processing)|go:"GO:0016604"(nuclear body)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070525"(tRNA threonylcarbamoyladenosine metabolic process)|interpro:IPR015419(Transcription factor Pcc1)|rcsb pdb:6GWJ|reactome:R-HSA-6782315	-	-	-	figure legend:Fig. S8B|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/02/19	2020/02/20	rogid:0VNjWOL8/4kDs/rbUhSgejc9blU9606	rogid:i85i7GnA4k4+zsftYKYMk+xWAFM9606	rigid:3y3ZESJngBLKvBIPRuF9StT+t24	false	ha tag:?-?	v5 tag:?-?|mutation with no effect:106-106(rs1557211306)|mutation with no effect:137-137(rs1557211209)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)