#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P83105	uniprotkb:Q9NRY2	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-2881520|ensembl:ENSP00000363360|uniprotkb:Q5VWJ7|uniprotkb:Q96E04|uniprotkb:Q9P090	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:sossc_human(display_long)|uniprotkb:INIP(gene name)|psi-mi:INIP(display_short)|uniprotkb:C9orf80(gene name synonym)|uniprotkb:INTS3- and NABP-interacting protein(gene name synonym)|uniprotkb:SSBIP1(gene name synonym)|uniprotkb:Sensor of single-strand DNA complex subunit C(gene name synonym)|uniprotkb:Sensor of ssDNA subunit C(gene name synonym)|uniprotkb:Single-stranded DNA-binding protein-interacting protein 1(gene name synonym)|uniprotkb:HSPC043(orf name)|uniprotkb:HSPC291(orf name)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENSG00000148153(gene)|ensembl:ENST00000374242(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0070876"(SOSS complex)|interpro:IPR031821|mint:Q9NRY2|rcsb pdb:4OWT|rcsb pdb:4OWW|refseq:NP_067041.1	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:1yTn7MGixuIKlmO+f3JXR1M4/UI9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P00403	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-2105756|uniprotkb:Q37526|ensembl:ENSP00000354876	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:cox2_human(display_long)|uniprotkb:MT-CO2(gene name)|psi-mi:MT-CO2(display_short)|uniprotkb:COII(gene name synonym)|uniprotkb:COXII(gene name synonym)|uniprotkb:MTCO2(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide II(gene name synonym)|uniprotkb:COX2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:YP_003024029.1|ensembl:ENSG00000198712(gene)|ensembl:ENST00000361739(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007595"(lactation)|go:"GO:0009409"(response to cold)|go:"GO:0010729"(positive regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042773"(ATP synthesis coupled electron transport)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR001505("Copper centre Cu(A)")|interpro:IPR002429(Cytochrome c oxidase subunit II C-terminal)|interpro:IPR008972(Cupredoxin)|interpro:IPR011759(Cytochrome C oxidase subunit II, transmembrane region)|interpro:IPR014222(Cytochrome c oxidase, subunit II)|interpro:IPR034210|interpro:IPR036257|mint:P00403|rcsb pdb:3VRJ|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:NyMmciQe53E935KEZahz8cGPjIM9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q13217	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-6165721|ensembl:ENSP00000473631|uniprotkb:Q86WT9|uniprotkb:Q8N4N2	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:dnjc3_human(display_long)|uniprotkb:DNAJC3(gene name)|psi-mi:DNAJC3(display_short)|uniprotkb:Interferon-induced, double-stranded RNA-activated protein kinase inhibitor(gene name synonym)|uniprotkb:P58IPK(gene name synonym)|uniprotkb:PRKRI(gene name synonym)|uniprotkb:Protein kinase inhibitor of 58 kDa(gene name synonym)|uniprotkb:Endoplasmic reticulum DNA J domain-containing protein 6(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENSG00000102580(gene)|ensembl:ENST00000602402(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0036494"(positive regulation of translation initiation in response to endoplasmic reticulum stress)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051607"(defense response to virus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070417"(cellular response to cold)|go:"GO:0051787"(misfolded protein binding)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR018704|interpro:IPR019734|interpro:IPR036869|rcsb pdb:2Y4T|rcsb pdb:2Y4U|reactome:R-HSA-192823|reactome:R-HSA-381038|reactome:R-HSA-381426|reactome:R-HSA-6798695|reactome:R-HSA-8957275|refseq:NP_006251.1	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:p5PToTl/u3ZL9PtRSjDK01FKJmc9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P55795	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-352823|ensembl:ENSP00000361927|uniprotkb:Q9HHA7|uniprotkb:A1L400	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:hnrh2_human(display_long)|uniprotkb:HNRNPH2(gene name)|psi-mi:HNRNPH2(display_short)|uniprotkb:FTP3(gene name synonym)|uniprotkb:HNRPH2(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein H'(gene name synonym)|uniprotkb:FTP-3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENSG00000126945(gene)|ensembl:ENST00000316594(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012996(Zinc finger, CHHC-type)|interpro:IPR035979|mint:P55795|rcsb pdb:1WEZ|rcsb pdb:1WG5|rcsb pdb:6DG1|reactome:R-HSA-72163|reactome:R-HSA-72203|interpro:IPR000504(RNA recognition motif, RNP-1)|refseq:NP_001027565.1|refseq:NP_062543.1	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:811j5syFsbk/QSaZv/ag9QsFUEQ9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q14566	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-374900|uniprotkb:Q13504|uniprotkb:Q99859|uniprotkb:B2R6H2|ensembl:ENSP00000264156	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:mcm6_human(display_long)|uniprotkb:MCM6(gene name)|psi-mi:MCM6(display_short)|uniprotkb:p105MCM(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENST00000264156(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0042555"(MCM complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902969"(mitotic DNA replication)|ensembl:ENSG00000076003(gene)|reactome:R-HSA-68962|reactome:R-HSA-69052|interpro:IPR008049(MCM protein 6)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041024|interpro:IPR041562|interpro:IPR001208(MCM)|mint:Q14566|rcsb pdb:2KLQ|rcsb pdb:2LE8|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|refseq:NP_005906.2|dip:DIP-31727N	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:gVpEwgfSwwxvP2T2CvCzIukthY49606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:O75128	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-3446582|uniprotkb:A4D257|uniprotkb:B7ZLW9|uniprotkb:B9EGF8|uniprotkb:Q8TCM1|uniprotkb:Q8N304|uniprotkb:A7E2B0|uniprotkb:Q86XA7|uniprotkb:Q504Y4|uniprotkb:Q2T9J3|intact:EBI-28974386|ensembl:ENSP00000265136	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:cobl_human(display_long)|uniprotkb:COBL(gene name)|psi-mi:COBL(display_short)|uniprotkb:KIAA0633(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENSP00000265136|ensembl:ENST00000395540|ensembl:ENSP00000378910|ensembl:ENST00000395542|ensembl:ENSP00000378912|ensembl:ENST00000441453|ensembl:ENSP00000399500|refseq:XP_011513537.1|refseq:NP_056013.2|refseq:NP_001274365.1|refseq:NP_001274367.1|refseq:NP_001333370.1|refseq:NP_001333371.1|refseq:NP_001333372.1|refseq:NP_001333373.1|ensembl:ENSG00000106078(gene)|ensembl:ENST00000265136(transcript)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0001726"(ruffle)|go:"GO:0001757"(somite specification)|go:"GO:0001843"(neural tube closure)|go:"GO:0001889"(liver development)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0016020"(membrane)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030903"(notochord development)|go:"GO:0033504"(floor plate development)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048565"(digestive tract development)|go:"GO:0048669"(collateral sprouting in absence of injury)|go:"GO:0051639"(actin filament network formation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1990357"(terminal web)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR019025|interpro:IPR039895|mint:O75128|rcsb pdb:4PL8	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:mkEX2B5sVoK8CD6RWVVCp912otg9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q7L7X3	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-1384314|uniprotkb:Q96L75|uniprotkb:Q9H2K7|uniprotkb:Q9H7S5|uniprotkb:Q9P2I6|uniprotkb:A2RUT8|uniprotkb:B7ZLV6|ensembl:ENSP00000261716	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:taok1_human(display_long)|uniprotkb:Prostate-derived sterile 20-like kinase 2(gene name synonym)|uniprotkb:Thousand and one amino acid protein kinase 1(gene name synonym)|uniprotkb:TAOK1(gene name)|psi-mi:TAOK1(display_short)|uniprotkb:KIAA1361(gene name synonym)|uniprotkb:MAP3K16(gene name synonym)|uniprotkb:MARKK(gene name synonym)|uniprotkb:MARK Kinase(gene name synonym)|uniprotkb:Kinase from chicken homolog B(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:XP_011523362.1|refseq:NP_065842.1|refseq:NP_079418.1|dip:DIP-39709N|ensembl:ENSG00000160551(gene)|ensembl:ENST00000261716(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016740"(transferase activity)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901985"(positive regulation of protein acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:tfE56A9/KSEBu1lgTyvfrGC9kn89606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P61088	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:O43399	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-782604|uniprotkb:Q5U0E0|uniprotkb:Q5JWU6|uniprotkb:Q9H3Z6|intact:EBI-1043547|uniprotkb:O43398|uniprotkb:Q5JWU5|uniprotkb:Q5JWU8|uniprotkb:E1P5G7|uniprotkb:B4DPJ6|ensembl:ENSP00000343547	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:tpd54_human(display_long)|uniprotkb:Tumor protein D52-like 2(gene name synonym)|uniprotkb:TPD52L2(gene name)|psi-mi:TPD52L2(display_short)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001230821.1|refseq:NP_003279.2|refseq:NP_955393.1|refseq:NP_955395.1|refseq:NP_955394.1|refseq:NP_955392.1|ensembl:ENSG00000101150(gene)|ensembl:ENST00000346249(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR007327(Tumor protein D52)|interpro:IPR012341(Six-hairpin glycosidase)|mint:O43399	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:asqRlZnmqIzXCJ5TAHjxKcj046g9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P55327	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-782581|uniprotkb:E5RKB4|uniprotkb:Q13056|uniprotkb:Q6FGP3|uniprotkb:Q6FGS3|uniprotkb:Q86YZ2|uniprotkb:B7Z414|uniprotkb:Q53EK8|uniprotkb:Q9UCX8|uniprotkb:C9J502|uniprotkb:D0UFD1|uniprotkb:D0UFD2|uniprotkb:D0UFD3|uniprotkb:D0UFD4|uniprotkb:D0UFD5|ensembl:ENSP00000368391	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:tpd52_human(display_long)|uniprotkb:Protein N8(gene name synonym)|uniprotkb:TPD52(gene name)|psi-mi:TPD52(display_short)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001020423.1|refseq:NP_001020424.1|refseq:NP_005070.1|refseq:NP_001274069.1|refseq:NP_001274071.1|refseq:NP_001274072.1|refseq:NP_001274073.1|ensembl:ENSG00000076554(gene)|ensembl:ENST00000379097(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0030183"(B cell differentiation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046903"(secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR007327(Tumor protein D52)|mint:P55327|reactome:R-HSA-432722	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:XNaAsDz2/29CkMFhPBhSmQsnOj49606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P10600	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-1033020|uniprotkb:Q8WV88|ensembl:ENSP00000238682|ensembl:ENSP00000502685	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:tgfb3_human(display_long)|uniprotkb:TGFB3(gene name)|psi-mi:TGFB3(display_short)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_003230.1|ensembl:ENSG00000119699(gene)|ensembl:ENST00000238682(transcript)|ensembl:ENST00000556674(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010936"(negative regulation of macrophage cytokine production)|go:"GO:0030315"(T-tubule)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030879"(mammary gland development)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032570"(response to progesterone)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0034714"(type III transforming growth factor beta receptor binding)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042476"(odontogenesis)|go:"GO:0042704"(uterine wall breakdown)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048565"(digestive tract development)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060364"(frontal suture morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0062009"(secondary palate development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070483"(detection of hypoxia)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905075"(positive regulation of tight junction disassembly)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR015618(Transforming growth factor beta 3)|interpro:IPR016319(Transforming growth factor-beta)|interpro:IPR017948|interpro:IPR029034|rcsb pdb:1KTZ|rcsb pdb:1TGJ|rcsb pdb:1TGK|rcsb pdb:2PJY|rcsb pdb:3EO1|rcsb pdb:4UM9|reactome:R-HSA-114608|reactome:R-HSA-2129379|reactome:R-HSA-3000178|refseq:NP_001316867.1|refseq:NP_001316868.1|dip:DIP-5937N	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:aQcAUgs6CAnHKZqIcOAdqiujRqM9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q99832	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-357046|uniprotkb:B7WNW9|uniprotkb:O14871|uniprotkb:Q6FI26|uniprotkb:A8K7E6|uniprotkb:A8MWI8|uniprotkb:B7Z4T9|uniprotkb:B7Z4Z7|ensembl:ENSP00000258091	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:tcph_human(display_long)|uniprotkb:CCT7(gene name)|psi-mi:CCT7(display_short)|uniprotkb:CCTH(gene name synonym)|uniprotkb:NIP7-1(gene name synonym)|uniprotkb:CCT-eta(gene name synonym)|uniprotkb:HIV-1 Nef-interacting protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	dip:DIP-51608N|refseq:NP_006420.1|refseq:XP_011530780.1|refseq:XP_011530781.1|refseq:NP_001009570.1|refseq:NP_001159756.1|refseq:NP_001159757.1|ensembl:ENSG00000135624(gene)|ensembl:ENST00000258091(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012720(T-complex protein 1, eta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:Q99832|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-6814122|reactome:R-HSA-9013418|reactome:R-HSA-9013422	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:buiW7iGdAbfcld/zMJOrkR2jxRo9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P17987	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-356553|uniprotkb:Q15556|uniprotkb:Q5TCM3|uniprotkb:E1P5B2|ensembl:ENSP00000317334	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:tcpa_human(display_long)|uniprotkb:CCTA(gene name synonym)|uniprotkb:TCP1(gene name)|psi-mi:TCP1(display_short)|uniprotkb:CCT1(gene name synonym)|uniprotkb:CCT-alpha(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_110379.2|ensembl:ENSG00000120438(gene)|ensembl:ENST00000321394(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000792"(heterochromatin)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:2000109"(regulation of macrophage apoptotic process)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044053"(translocation of peptides or proteins into host cell cytoplasm)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|interpro:IPR012715(T-complex protein 1, alpha subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|reactome:R-HSA-8950505|interpro:IPR027413|mint:P17987|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|dip:DIP-33676N	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:CYJ5rPjKOH3sAP+j0ckdHHu81g49606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P36873	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-356283|ensembl:ENSP00000335084	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:pp1g_human(display_long)|uniprotkb:PPP1CC(gene name)|psi-mi:PPP1CC(display_short)|uniprotkb:Protein phosphatase 1C catalytic subunit(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0004721"(phosphoprotein phosphatase activity)|ensembl:ENSG00000186298(gene)|ensembl:ENST00000335007(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000776"(kinetochore)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|go:"GO:0043197"(dendritic spine)|interpro:IPR029052|interpro:IPR031675|interpro:IPR037981|mint:P36873|rcsb pdb:1IT6|rcsb pdb:1JK7|rcsb pdb:1U32|rcsb pdb:2BCD|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046822"(regulation of nucleocytoplasmic transport)|rcsb pdb:2BDX|rcsb pdb:4UT2|rcsb pdb:4UT3|go:"GO:0046872"(metal ion binding)|rcsb pdb:5INB|go:"GO:0047485"(protein N-terminus binding)|rcsb pdb:5J28|go:"GO:0051301"(cell division)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098793"(presynapse)|reactome:R-HSA-141444|reactome:R-HSA-163560|reactome:R-HSA-2173788|reactome:R-HSA-9648025|reactome:R-HSA-9660537|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-400253|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-68877|refseq:NP_001231903.1|refseq:NP_002701.1|dip:DIP-749N	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:SyjV/4d9V8lV/BXub2KESPKvupA9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P62140	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-352350|uniprotkb:P37140|uniprotkb:Q5U087|uniprotkb:Q6FG45|uniprotkb:D6W565|uniprotkb:B2R5V4|ensembl:ENSP00000296122|ensembl:ENSP00000351298|ensembl:ENSP00000378769	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:pp1b_human(display_long)|uniprotkb:PPP1CB(gene name)|psi-mi:PPP1CB(display_short)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_002700.1|refseq:NP_996759.1|ensembl:ENSG00000213639(gene)|ensembl:ENST00000296122(transcript)|ensembl:ENST00000358506(transcript)|ensembl:ENST00000395366(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0016791"(phosphatase activity)|go:"GO:0017018"(myosin phosphatase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0046872"(metal ion binding)|go:"GO:0050115"(myosin-light-chain-phosphatase activity)|go:"GO:0051301"(cell division)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|mint:P62140|reactome:R-HSA-163560|reactome:R-HSA-2173788|reactome:R-HSA-2565942|reactome:R-HSA-400253|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|reactome:R-HSA-5673000|reactome:R-HSA-9660537|dip:DIP-33220N	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:VtNJVyimeiEuRDDWtGswTqoSOH89606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P62136	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-357253|uniprotkb:P08129|uniprotkb:P20653|uniprotkb:P22802|uniprotkb:B2R908|intact:EBI-2623163|uniprotkb:Q07161|intact:EBI-2556927|uniprotkb:A6NNR3|ensembl:ENSP00000365936	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:pp1a_human(display_long)|uniprotkb:PPP1CA(gene name)|psi-mi:PPP1CA(display_short)|uniprotkb:PPP1A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001008709.1|refseq:NP_002699.1|refseq:NP_996756.1|dip:DIP-221N|dip:DIP-38195N|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0051301"(cell division)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|interpro:IPR037979|mint:P62136|rcsb pdb:3E7A|rcsb pdb:3E7B|rcsb pdb:3EGG|rcsb pdb:3EGH|rcsb pdb:3HVQ|rcsb pdb:3N5U|rcsb pdb:3V4Y|rcsb pdb:4G9J|rcsb pdb:4MOV|rcsb pdb:4MOY|rcsb pdb:4MP0|rcsb pdb:4XPN|rcsb pdb:5IOH|rcsb pdb:6ALZ|rcsb pdb:6CZO|rcsb pdb:6DCX|rcsb pdb:6DNO|rcsb pdb:6G0I|rcsb pdb:6G0J|rcsb pdb:6GHM|rcsb pdb:6OBN|rcsb pdb:6OBP|rcsb pdb:6OBQ|rcsb pdb:6OBR|rcsb pdb:6OBS|rcsb pdb:6OBU|rcsb pdb:6ZEE|rcsb pdb:6ZEF|rcsb pdb:6ZEG|rcsb pdb:6ZEH|rcsb pdb:6ZEI|rcsb pdb:6ZEJ|rcsb pdb:6ZK6|reactome:R-HSA-163560|reactome:R-HSA-180024|reactome:R-HSA-2173788|reactome:R-HSA-400253|go:"GO:0098793"(presynapse)|ensembl:ENSG00000172531(gene)|ensembl:ENST00000376745(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0030324"(lung development)	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:IMypaKng+5AECbCd3N72pgzUlxQ9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q9BRF8	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-11305102|uniprotkb:Q9H9M9|uniprotkb:Q6MZY9|uniprotkb:Q9NUT6|uniprotkb:B4DQ68|ensembl:ENSP00000371193	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:cpped_human(display_long)|uniprotkb:CPPED1(gene name)|psi-mi:CPPED1(display_short)|uniprotkb:CSTP1(gene name synonym)|uniprotkb:Calcineurin-like phosphoesterase domain-containing protein 1(gene name synonym)|uniprotkb:Complete S-transactivated protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001092925.1|refseq:NP_060810.2|ensembl:ENSG00000103381(gene)|ensembl:ENST00000381774(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR029052|interpro:IPR041867|reactome:R-HSA-6798695	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:5bdWSCd8D97nsTvUbxWdeStJJb89606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P30153	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-302388|uniprotkb:Q13773|uniprotkb:Q6ICQ3|uniprotkb:Q96DH3|ensembl:ENSP00000324804	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:2aaa_human(display_long)|uniprotkb:PPP2R1A(gene name)|psi-mi:PPP2R1A(display_short)|uniprotkb:PP2A subunit A isoform PR65-alpha(gene name synonym)|uniprotkb:PP2A subunit A isoform R1-alpha(gene name synonym)|uniprotkb:Medium tumor antigen-associated 61 kDa protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENSG00000105568(gene)|ensembl:ENST00000322088(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008380"(RNA splicing)|go:"GO:0010033"(response to organic substance)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019932"(second-messenger-mediated signaling)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990405"(protein antigen binding)|interpro:IPR000357(HEAT)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR031090|mint:P30153|rcsb pdb:1B3U|rcsb pdb:2IE3|rcsb pdb:2IE4|rcsb pdb:2NPP|rcsb pdb:2NYL|rcsb pdb:2NYM|rcsb pdb:2PKG|rcsb pdb:3C5W|rcsb pdb:3DW8|rcsb pdb:3K7V|rcsb pdb:3K7W|rcsb pdb:4I5L|rcsb pdb:4I5N|rcsb pdb:4LAC|rcsb pdb:5W0W|rcsb pdb:6IUR|rcsb pdb:6NTS|rcsb pdb:7CUN|rcsb pdb:7K36|reactome:R-HSA-113501|reactome:R-HSA-1295596|reactome:R-HSA-141444|reactome:R-HSA-163685|reactome:R-HSA-163767|reactome:R-HSA-180024|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2465910|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-2995383|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-389513|reactome:R-HSA-432142|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6804757|reactome:R-HSA-6811558|reactome:R-HSA-68877|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-8854518|reactome:R-HSA-9634600|reactome:R-HSA-9648025|reactome:R-HSA-975957|refseq:NP_055040.2|dip:DIP-29394N	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:73tR8yYYvViK8JdgIg18XWc3HRc9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P25815	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-743700|uniprotkb:Q5J7W2|ensembl:ENSP00000296370	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:s100p_human(display_long)|uniprotkb:S100 calcium-binding protein P(gene name synonym)|uniprotkb:S100P(gene name)|psi-mi:S100P(display_short)|uniprotkb:S100E(gene name synonym)|uniprotkb:Protein S100-E(gene name synonym)|uniprotkb:Migration-inducing gene 9 protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_005971.1|ensembl:ENSG00000163993(gene)|ensembl:ENST00000296370(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0010033"(response to organic substance)|go:"GO:0031528"(microvillus membrane)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045296"(cadherin binding)|go:"GO:0046914"(transition metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR034325|rcsb pdb:1J55|rcsb pdb:1OZO|rcsb pdb:2MJW|reactome:R-HSA-6798695|interpro:IPR011992(EF-Hand type)	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:wuvwIPFST5gUGqRSJmkUw+CbJv49606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P06702	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-1055001|uniprotkb:Q6FGA1|uniprotkb:Q9NYM0|uniprotkb:Q9UCJ1|uniprotkb:D3DV36|ensembl:ENSP00000357727	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:s10a9_human(display_long)|uniprotkb:S100 calcium-binding protein A9(gene name synonym)|uniprotkb:Calgranulin-B(gene name synonym)|uniprotkb:Migration inhibitory factor-related protein 14(gene name synonym)|uniprotkb:Leukocyte L1 complex heavy chain(gene name synonym)|uniprotkb:Calprotectin L1H subunit(gene name synonym)|uniprotkb:S100A9(gene name)|psi-mi:S100A9(display_short)|uniprotkb:CAGB(gene name synonym)|uniprotkb:CFAG(gene name synonym)|uniprotkb:MRP14(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_002956.1|rcsb pdb:1XK4|rcsb pdb:4GGF|rcsb pdb:4XJK|rcsb pdb:5I8N|rcsb pdb:5W1F|rcsb pdb:6DS2|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5668599|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-6799990|ensembl:ENSG00000163220(gene)|ensembl:ENST00000368738(transcript)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0035662"(Toll-like receptor 4 binding)|go:"GO:0035821"(modulation of process of another organism)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0045113"(regulation of integrin biosynthetic process)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050544"(arachidonic acid binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070488"(neutrophil aggregation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|mint:P06702|rcsb pdb:1IRJ|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0016209"(antioxidant activity)|go:"GO:0018119"(peptidyl-cysteine S-nitrosylation)|go:"GO:0030054"(cell junction)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032119"(sequestering of zinc ion)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035425"(autocrine signaling)|go:"GO:0035606"(peptidyl-cysteine S-trans-nitrosylation)|dip:DIP-1166N	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:IGnX4DSnv8xMr5pY4T7X7vYos5A9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q86SG5	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-13077820|ensembl:ENSP00000329008|ensembl:ENSP00000357717|ensembl:ENSP00000357718|uniprotkb:D3DV38|uniprotkb:Q5SY69	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:s1a7a_human(display_long)|uniprotkb:S100A7A(gene name)|psi-mi:S100A7A(display_short)|uniprotkb:S100 calcium-binding protein A15(gene name synonym)|uniprotkb:S100 calcium-binding protein A7-like 1(gene name synonym)|uniprotkb:S100 calcium-binding protein A7A(gene name synonym)|uniprotkb:S100A15(gene name synonym)|uniprotkb:S100A7L1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENSG00000184330(gene)|ensembl:ENST00000329256(transcript)|ensembl:ENST00000368728(transcript)|ensembl:ENST00000368729(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0043621"(protein self-association)|go:"GO:0046914"(transition metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|interpro:IPR028477|interpro:IPR034325|rcsb pdb:4AQI|reactome:R-HSA-6799990|refseq:NP_789793.1	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:tvDSD+pF9aL+bt9hSvM7o5zpfpE9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P31151	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-357520|uniprotkb:Q6FGE3|uniprotkb:Q5SY67|uniprotkb:Q9H1E2|ensembl:ENSP00000357711|ensembl:ENSP00000357712	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:s10a7_human(display_long)|uniprotkb:S100A7(gene name)|psi-mi:S100A7(display_short)|uniprotkb:PSOR1(gene name synonym)|uniprotkb:S100A7C(gene name synonym)|uniprotkb:S100 calcium-binding protein A7(gene name synonym)|uniprotkb:Psoriasin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENSG00000143556(gene)|ensembl:ENST00000368722(transcript)|ensembl:ENST00000368723(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001525"(angiogenesis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008544"(epidermis development)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0045087"(innate immune response)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051238"(sequestering of metal ion)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071624"(positive regulation of granulocyte chemotaxis)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|interpro:IPR028477|interpro:IPR034325|mint:P31151|rcsb pdb:1PSR|rcsb pdb:2PSR|rcsb pdb:2WND|rcsb pdb:2WOR|rcsb pdb:2WOS|rcsb pdb:3PSR|rcsb pdb:4AQJ|reactome:R-HSA-6798695|reactome:R-HSA-6799990|refseq:NP_002954.2	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:/v8+XQ7rCMTYzq9k/KqjcSm/G0A9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P06703	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-352877|ensembl:ENSP00000357708|ensembl:ENSP00000357709|ensembl:ENSP00000473589|uniprotkb:Q5RHS4|uniprotkb:D3DV39	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:s10a6_human(display_long)|uniprotkb:S100A6(gene name)|psi-mi:S100A6(display_short)|uniprotkb:CACY(gene name synonym)|uniprotkb:S100 calcium-binding protein A6(gene name synonym)|uniprotkb:Calcyclin(gene name synonym)|uniprotkb:Prolactin receptor-associated protein(gene name synonym)|uniprotkb:Growth factor-inducible protein 2A9(gene name synonym)|uniprotkb:MLN 4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENSG00000197956(gene)|ensembl:ENST00000368719(transcript)|ensembl:ENST00000368720(transcript)|ensembl:ENST00000496817(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015075"(ion transmembrane transporter activity)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044548"(S100 protein binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|interpro:IPR034118|mint:P06703|rcsb pdb:1K8U|rcsb pdb:1K96|rcsb pdb:1K9K|rcsb pdb:1K9P|rcsb pdb:2M1K|rcsb pdb:4YBH|go:"GO:0062023"(collagen-containing extracellular matrix)|refseq:NP_055439.1|refseq:XP_016857522.1	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:y8rq2lO1c3DEoVaKnfoLEAHsqmo9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P26447	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-717058|uniprotkb:Q6ICP8|uniprotkb:A8K7R8|uniprotkb:D3DV46|ensembl:ENSP00000346294|ensembl:ENSP00000357703|ensembl:ENSP00000357704|ensembl:ENSP00000357705	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:s10a4_human(display_long)|uniprotkb:S100 calcium-binding protein A4(gene name synonym)|uniprotkb:Metastasin(gene name synonym)|uniprotkb:Protein Mts1(gene name synonym)|uniprotkb:Placental calcium-binding protein(gene name synonym)|uniprotkb:Calvasculin(gene name synonym)|uniprotkb:S100A4(gene name)|psi-mi:S100A4(display_short)|uniprotkb:CAPL(gene name synonym)|uniprotkb:MTS1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_002952.1|refseq:NP_062427.1|ensembl:ENSG00000196154(gene)|ensembl:ENST00000354332(transcript)|ensembl:ENST00000368714(transcript)|ensembl:ENST00000368715(transcript)|ensembl:ENST00000368716(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046914"(transition metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|interpro:IPR028496|interpro:IPR034325|mint:P26447|rcsb pdb:1M31|rcsb pdb:2LNK|rcsb pdb:2MRD|rcsb pdb:2Q91|rcsb pdb:3C1V|rcsb pdb:3CGA|rcsb pdb:3KO0|rcsb pdb:3M0W|rcsb pdb:3ZWH|rcsb pdb:4CFQ|rcsb pdb:4CFR|rcsb pdb:4ETO|rcsb pdb:4HSZ|rcsb pdb:5LPU|rcsb pdb:6T58|dip:DIP-44938N	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:58+txYVmiPdBmohFbqquykr9fT49606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q96FQ6	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-751850|uniprotkb:Q5RHS6|uniprotkb:A8K439|uniprotkb:D3DV52|ensembl:ENSP00000357692|ensembl:ENSP00000357693|ensembl:ENSP00000357694|ensembl:ENSP00000357695	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:s10ag_human(display_long)|uniprotkb:S100 calcium-binding protein A16(gene name synonym)|uniprotkb:S100F(gene name synonym)|uniprotkb:Aging-associated gene 13 protein(gene name synonym)|uniprotkb:S100A16(gene name)|psi-mi:S100A16(display_short)|uniprotkb:AAG13(orf name)|uniprotkb:Protein S100-F(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_525127.1|refseq:NP_001303936.1|refseq:NP_001303937.1|ensembl:ENSG00000188643(gene)|ensembl:ENST00000368703(transcript)|ensembl:ENST00000368704(transcript)|ensembl:ENST00000368705(transcript)|ensembl:ENST00000368706(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|interpro:IPR028485|rcsb pdb:2L50|rcsb pdb:2L51|rcsb pdb:3NXA	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:M+5KVW40pdHYoehBeVduPhItQAg9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q9HCY8	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-751842|uniprotkb:Q5RHT0|ensembl:ENSP00000340463|ensembl:ENSP00000357690|ensembl:ENSP00000357691|ensembl:ENSP00000420296	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:s10ae_human(display_long)|uniprotkb:S100 calcium-binding protein A14(gene name synonym)|uniprotkb:S100A14(gene name)|psi-mi:S100A14(display_short)|uniprotkb:S100A15(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_065723.1|refseq:XP_005245419.1|refseq:XP_016857364.1|ensembl:ENSG00000189334(gene)|ensembl:ENST00000344616(transcript)|ensembl:ENST00000368701(transcript)|ensembl:ENST00000368702(transcript)|ensembl:ENST00000476873(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071624"(positive regulation of granulocyte chemotaxis)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR028493|mint:Q9HCY8|rcsb pdb:2M0R	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:8XSIQKZSb+jAmTmawRUTHjcGwb49606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q99584	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-721909|uniprotkb:Q52PI9|uniprotkb:Q6FGF8|ensembl:ENSP00000344822|ensembl:ENSP00000376398|ensembl:ENSP00000376399|ensembl:ENSP00000392767|ensembl:ENSP00000507299	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:s10ad_human(display_long)|uniprotkb:S100 calcium-binding protein A13(gene name synonym)|uniprotkb:S100A13(gene name)|psi-mi:S100A13(display_short)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001019381.1|refseq:NP_001019382.1|refseq:NP_001019383.1|refseq:NP_001019384.1|refseq:NP_005970.1|refseq:XP_011508164.1|refseq:XP_011508165.1|refseq:XP_011508166.1|refseq:XP_005245491.1|refseq:XP_016857523.1|refseq:XP_016857524.1|refseq:XP_016857525.1|ensembl:ENSG00000189171(gene)|ensembl:ENST00000339556(transcript)|ensembl:ENST00000392622(transcript)|ensembl:ENST00000392623(transcript)|ensembl:ENST00000440685(transcript)|ensembl:ENST00000476133(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0015031"(protein transport)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0032730"(positive regulation of interleukin-1 alpha production)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050786"(RAGE receptor binding)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR028487|rcsb pdb:1YUR|rcsb pdb:1YUS|rcsb pdb:1YUT|rcsb pdb:1YUU|rcsb pdb:2EGD|rcsb pdb:2H2K|rcsb pdb:2K8M|rcsb pdb:2KI4|rcsb pdb:2KI6|rcsb pdb:2KOT|rcsb pdb:2L5X|rcsb pdb:2LE9	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:TSQW3OvBldoNzNN2g6uxgUJAjUg9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q9P258	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-352547|uniprotkb:Q8IVL9|uniprotkb:Q9BSN6|uniprotkb:Q9NPV8|ensembl:ENSP00000364582|ensembl:ENSP00000364585|ensembl:ENSP00000486099|ensembl:ENSP00000486447	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:rcc2_human(display_long)|uniprotkb:RCC2(gene name)|psi-mi:RCC2(display_short)|uniprotkb:KIAA1470(gene name synonym)|uniprotkb:TD60(gene name synonym)|uniprotkb:Telophase disk protein of 60 kDa(gene name synonym)|uniprotkb:RCC1-like protein TD-60(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001129676.1|refseq:NP_061185.1|ensembl:ENSG00000179051(gene)|ensembl:ENSG00000281540(gene)|ensembl:ENST00000375433(transcript)|ensembl:ENST00000375436(transcript)|ensembl:ENST00000628984(transcript)|ensembl:ENST00000631021(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034506"(chromosome, centromeric core domain)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051301"(cell division)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051987"(positive regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0072356"(chromosome passenger complex localization to kinetochore)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR028641|mint:Q9P258|rcsb pdb:5GWN|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:z9+0avftBLs4Q3ODFHLEmJtd57A9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q92597	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-716486|uniprotkb:O15207|uniprotkb:Q9NYR6|uniprotkb:Q9UK29|uniprotkb:Q6IBG2|uniprotkb:B3KR80|uniprotkb:B7Z446|ensembl:ENSP00000319977|ensembl:ENSP00000404854	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:ndrg1_human(display_long)|uniprotkb:N-myc downstream-regulated gene 1 protein(gene name synonym)|uniprotkb:Differentiation-related gene 1 protein(gene name synonym)|uniprotkb:Reducing agents and tunicamycin-responsive protein(gene name synonym)|uniprotkb:Nickel-specific induction protein Cap43(gene name synonym)|uniprotkb:Rit42(gene name synonym)|uniprotkb:NDRG1(gene name)|psi-mi:NDRG1(display_short)|uniprotkb:CAP43(gene name synonym)|uniprotkb:DRG1(gene name synonym)|uniprotkb:RTP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001128714.1|refseq:NP_006087.2|refseq:NP_001245361.1|refseq:NP_001245362.1|ensembl:ENSG00000104419(gene)|ensembl:ENST00000323851(transcript)|ensembl:ENST00000414097(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007165"(signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010038"(response to metal ion)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045576"(mast cell activation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099173"(postsynapse organization)|interpro:IPR004142(Ndr)|interpro:IPR029058|interpro:IPR030693|rcsb pdb:6ZMM|reactome:R-HSA-6803205	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:zeyNRbcgqPcHXkqwE42s1e9uEqI9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P28070	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-603350|uniprotkb:P31148|uniprotkb:Q5SZS5|uniprotkb:Q969L6|uniprotkb:B2R9L3|uniprotkb:Q6IBI4|ensembl:ENSP00000290541	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:psb4_human(display_long)|uniprotkb:PSMB4(gene name)|psi-mi:PSMB4(display_short)|uniprotkb:Macropain beta chain(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex beta chain(gene name synonym)|uniprotkb:Proteasome chain 3(gene name synonym)|uniprotkb:26 kDa prosomal protein(gene name synonym)|uniprotkb:PROS26(gene name synonym)|uniprotkb:Proteasome beta chain(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_002787.2|dip:DIP-33844N|ensembl:ENSG00000159377(gene)|ensembl:ENST00000290541(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004298"(threonine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019774"(proteasome core complex, beta-subunit complex)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR016050(Proteasome, beta-type subunit, conserved site)|interpro:IPR016295(Proteasome endopeptidase complex, beta subunit)|interpro:IPR023333|interpro:IPR029055|mint:P28070|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:drR+ktPXQK9ep6hs7OYb5SmQnXU9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P98170	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-517127|uniprotkb:Q9NQ14|uniprotkb:D3DTF2|ensembl:ENSP00000347858|ensembl:ENSP00000360242|ensembl:ENSP00000395230	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:xiap_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 3(gene name synonym)|uniprotkb:X-linked inhibitor of apoptosis protein(gene name synonym)|uniprotkb:IAP-like protein(gene name synonym)|uniprotkb:XIAP(gene name)|psi-mi:XIAP(display_short)|uniprotkb:API3(gene name synonym)|uniprotkb:IAP3(gene name synonym)|uniprotkb:BIRC4(gene name synonym)|uniprotkb:Baculoviral IAP repeat-containing protein 4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase XIAP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:XP_006724817.1|refseq:NP_001158.2|refseq:NP_001191330.1|refseq:XP_011529631.1|dip:DIP-27626N|ensembl:ENSG00000101966(gene)|ensembl:ENST00000355640(transcript)|ensembl:ENST00000371199(transcript)|ensembl:ENST00000434753(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055070"(copper ion homeostasis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR042579|mint:P98170|rcsb pdb:1C9Q|rcsb pdb:1F9X|rcsb pdb:1G3F|rcsb pdb:1G73|rcsb pdb:1I3O|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1KMC|rcsb pdb:1NW9|rcsb pdb:1TFQ|rcsb pdb:1TFT|rcsb pdb:2ECG|rcsb pdb:2JK7|rcsb pdb:2KNA|rcsb pdb:2OPY|rcsb pdb:2OPZ|rcsb pdb:2POI|rcsb pdb:2POP|rcsb pdb:2QRA|rcsb pdb:2VSL|rcsb pdb:3CLX|rcsb pdb:3CM2|rcsb pdb:3CM7|rcsb pdb:3EYL|rcsb pdb:3G76|rcsb pdb:3HL5|rcsb pdb:3UW4|rcsb pdb:3UW5|rcsb pdb:4EC4|rcsb pdb:4HY0|rcsb pdb:4IC2|rcsb pdb:4IC3|rcsb pdb:4J3Y|rcsb pdb:4J44|rcsb pdb:4J45|rcsb pdb:4J46|rcsb pdb:4J47|rcsb pdb:4J48|rcsb pdb:4KJU|rcsb pdb:4KJV|rcsb pdb:4KMP|rcsb pdb:4MTZ|rcsb pdb:4OXC|rcsb pdb:4WVS|rcsb pdb:4WVT|rcsb pdb:4WVU|rcsb pdb:5C0K|rcsb pdb:5C0L|rcsb pdb:5C3H|rcsb pdb:5C3K|rcsb pdb:5C7A|rcsb pdb:5C7B|rcsb pdb:5C7C|rcsb pdb:5C7D|rcsb pdb:5C83|rcsb pdb:5C84|rcsb pdb:5M6E|rcsb pdb:5M6F|rcsb pdb:5M6H|rcsb pdb:5M6L|rcsb pdb:5M6M|rcsb pdb:5O6T|rcsb pdb:5OQW|rcsb pdb:6EY2|rcsb pdb:6GJW|rcsb pdb:6QCI|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-111469|reactome:R-HSA-3769402|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-9627069	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:6eDcOay+c2ZmIAD/pwnCDROBwgM9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P49720	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-603340|uniprotkb:P31147|uniprotkb:Q0P6J7|uniprotkb:Q96E27|ensembl:ENSP00000483688|ensembl:ENSP00000483956	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:psb3_human(display_long)|uniprotkb:PSMB3(gene name)|psi-mi:PSMB3(display_short)|uniprotkb:Proteasome theta chain(gene name synonym)|uniprotkb:Proteasome chain 13(gene name synonym)|uniprotkb:Proteasome component C10-II(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_002786.2|dip:DIP-33846N|ensembl:ENSG00000275903(gene)|ensembl:ENSG00000277791(gene)|ensembl:ENST00000619426(transcript)|ensembl:ENST00000619951(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004298"(threonine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019774"(proteasome core complex, beta-subunit complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR016050(Proteasome, beta-type subunit, conserved site)|interpro:IPR023333|interpro:IPR029055|interpro:IPR033811|mint:P49720|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:H4UDdXV1BaXHp6mEPafNy+Iv8389606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P60900	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-357793|uniprotkb:P34062|uniprotkb:Q6IB60|uniprotkb:B2R7J9|uniprotkb:B4DQR4|uniprotkb:B4DXJ9|ensembl:ENSP00000261479	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:psa6_human(display_long)|uniprotkb:PSMA6(gene name)|psi-mi:PSMA6(display_short)|uniprotkb:PROS27(gene name synonym)|uniprotkb:Proteasome iota chain(gene name synonym)|uniprotkb:Macropain iota chain(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex iota chain(gene name synonym)|uniprotkb:27 kDa prosomal protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_002782.1|refseq:NP_001269162.1|refseq:NP_001269163.1|refseq:XP_016876957.1|refseq:NP_001269161.1|ensembl:ENSG00000100902(gene)|ensembl:ENST00000261479(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0005844"(polysome)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0030016"(myofibril)|go:"GO:0030017"(sarcomere)|go:"GO:0035639"(purine ribonucleoside triphosphate binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR023332|interpro:IPR029055|interpro:IPR034642|mint:P60900|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-29367N	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:F+Kwr6rnDS3jD53gBGHDIn7HV/89606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:O75340	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-352915|uniprotkb:E7ESR3|uniprotkb:Q5TZS0|uniprotkb:B2RD16|uniprotkb:Q2YDC2|ensembl:ENSP00000264933	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:pdcd6_human(display_long)|uniprotkb:PDCD6(gene name)|psi-mi:PDCD6(display_short)|uniprotkb:ALG2(gene name synonym)|uniprotkb:Apoptosis-linked gene 2 protein homolog(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	go:"GO:0036324"(vascular endothelial growth factor receptor-2 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:O75340|rcsb pdb:2ZN8|rcsb pdb:2ZN9|rcsb pdb:2ZND|rcsb pdb:2ZNE|rcsb pdb:2ZRS|rcsb pdb:2ZRT|rcsb pdb:3AAJ|rcsb pdb:3AAK|rcsb pdb:3WXA|rcsb pdb:5GQQ|go:"GO:0046983"(protein dimerization activity)|refseq:NP_037364.1|refseq:NP_001254485.1|refseq:NP_001254486.1|refseq:NP_001254487.1|refseq:NP_001254488.1|ensembl:ENSG00000249915(gene)|ensembl:ENST00000264933(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0014029"(neural crest formation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034605"(cellular response to heat)|dip:DIP-33217N	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:qbNAx73X9TJNr0MVNcy7Q9qN3Hg9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:O14737	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-712290|ensembl:ENSP00000466214|uniprotkb:Q53YC9|uniprotkb:Q6IB70|uniprotkb:B4DE64	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:pdcd5_human(display_long)|uniprotkb:TF-1 cell apoptosis-related protein 19(gene name synonym)|uniprotkb:PDCD5(gene name)|psi-mi:PDCD5(display_short)|uniprotkb:TFAR19(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	go:"GO:0010698"(acetyltransferase activator activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:1903638"(positive regulation of protein insertion into mitochondrial outer membrane)|go:"GO:1903645"(negative regulation of chaperone-mediated protein folding)|mint:O14737|rcsb pdb:1YYB|rcsb pdb:2CRU|rcsb pdb:2K6B|interpro:IPR002836(DNA-binding TFAR19-related protein)|interpro:IPR036883|ensembl:ENSG00000105185(gene)|ensembl:ENST00000590247(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008201"(heparin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|refseq:NP_004699.1|refseq:XP_005259449.1|dip:DIP-50602N	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:K2DZzTWT7H8gGATfyR72aXDu5qc9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q9BUL8	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-740195|uniprotkb:O14811|uniprotkb:D3DNN5|ensembl:ENSP00000376506|ensembl:ENSP00000417202|ensembl:ENSP00000418317|ensembl:ENSP00000420021|ensembl:ENSP00000420553|uniprotkb:A8K515|intact:EBI-2556229	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:pdc10_human(display_long)|uniprotkb:PDCD10(gene name)|psi-mi:PDCD10(display_short)|uniprotkb:CCM3(gene name synonym)|uniprotkb:TFAR15(gene name synonym)|uniprotkb:TF-1 cell apoptosis-related protein 15(gene name synonym)|uniprotkb:Cerebral cavernous malformations 3 protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENSG00000114209(gene)|ensembl:ENST00000392750(transcript)|ensembl:ENST00000461494(transcript)|ensembl:ENST00000470131(transcript)|ensembl:ENST00000473645(transcript)|ensembl:ENST00000497056(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0036481"(intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0090443"(FAR/SIN/STRIPAK complex)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR009652(Protein of unknown function DUF1241)|rcsb pdb:3AJM|rcsb pdb:3L8I|rcsb pdb:3L8J|rcsb pdb:3RQE|rcsb pdb:3RQF|rcsb pdb:3RQG|rcsb pdb:3W8H|rcsb pdb:3W8I|rcsb pdb:4GEH|rcsb pdb:4TVQ|refseq:NP_009148.2|refseq:NP_665858.1|refseq:NP_665859.1|refseq:XP_011510670.1|refseq:XP_011510671.1|refseq:XP_005247143.1|refseq:XP_005247144.1|refseq:XP_005247145.1|refseq:XP_006713548.1|refseq:XP_016861133.1|dip:DIP-40607N	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:BVHrFpHNErUWVLO0A48Un1COLhM9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q9UGN5	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-2795348|uniprotkb:Q8TEU4|uniprotkb:Q9NUV2|uniprotkb:Q9UMR4|uniprotkb:Q9Y6C8|ensembl:ENSP00000250416	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:parp2_human(display_long)|uniprotkb:PARP2(gene name)|psi-mi:PARP2(display_short)|uniprotkb:ADPRT2(gene name synonym)|uniprotkb:ADPRTL2(gene name synonym)|uniprotkb:"NAD(+) ADP-ribosyltransferase 2"(gene name synonym)|uniprotkb:Poly[ADP-ribose] synthase 2(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 2(gene name synonym)|uniprotkb:DNA ADP-ribosyltransferase PARP2(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase PARP2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001036083.1|refseq:NP_005475.2|ensembl:ENSG00000129484(gene)|ensembl:ENST00000250416(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0016570"(histone modification)|go:"GO:0018312"(peptidyl-serine ADP-ribosylation)|go:"GO:0030592"(DNA ADP-ribosylation)|go:"GO:0031491"(nucleosome binding)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0140294"(NAD DNA ADP-ribosyltransferase activity)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR004102("Poly(ADP-ribose) polymerase, regulatory region")|interpro:IPR008893(WGR)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR036616|go:"GO:0005634"(nucleus)|interpro:IPR036930|mint:Q9UGN5|rcsb pdb:3KCZ|rcsb pdb:3KJD|rcsb pdb:4PJV|rcsb pdb:4TVJ|rcsb pdb:4ZZX|rcsb pdb:4ZZY|rcsb pdb:5D5K|rcsb pdb:5DSY|rcsb pdb:6F1K|rcsb pdb:6F5B|rcsb pdb:6F5F|rcsb pdb:6TX3|rcsb pdb:6USJ|rcsb pdb:6X0L|rcsb pdb:6X0M|rcsb pdb:6X0N|rcsb pdb:7AEO|reactome:R-HSA-110362|reactome:R-HSA-5685939|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|dip:DIP-48934N	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:0sLs7K5dQNmmhUwnGT9UIvparjU9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q6P1J9	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-930143|uniprotkb:A6NLZ8|uniprotkb:Q6PK51|uniprotkb:Q96A07|uniprotkb:Q9H245|uniprotkb:Q9H5L7|uniprotkb:B2RBR2|ensembl:ENSP00000356405	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:cdc73_human(display_long)|uniprotkb:CDC73(gene name)|psi-mi:CDC73(display_short)|uniprotkb:C1orf28(gene name synonym)|uniprotkb:HRPT2(gene name synonym)|uniprotkb:Cell division cycle protein 73 homolog(gene name synonym)|uniprotkb:Hyperparathyroidism 2 protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_078805.3|dip:DIP-37884N|ensembl:ENSG00000134371(gene)|ensembl:ENST00000367435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0031648"(protein destabilization)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034402"(recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR007852(RNA polymerase II accessory factor, Cdc73)|interpro:IPR031336|interpro:IPR032041|interpro:IPR038103|mint:Q6P1J9|rcsb pdb:5YDE|rcsb pdb:5YDF|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-201722|reactome:R-HSA-5632684|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:nuJ2kK0petj8iBr17I2BQzxcVmE9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q96TA1	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-2514593|uniprotkb:Q4LE55|uniprotkb:Q5VVW7|intact:EBI-28984656|ensembl:ENSP00000362409|uniprotkb:Q9NT35|uniprotkb:Q9BUS2|uniprotkb:Q5VVW6	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:niba2_human(display_long)|uniprotkb:NIBAN2(gene name)|psi-mi:NIBAN2(display_short)|uniprotkb:C9orf88(gene name synonym)|uniprotkb:FAM129B(gene name synonym)|uniprotkb:Meg-3(gene name synonym)|uniprotkb:Melanoma invasion by ERK(gene name synonym)|uniprotkb:Niban-like protein 1(gene name synonym)|uniprotkb:Protein FAM129B(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR026088|mint:Q96TA1|rcsb pdb:7CTP|ensembl:ENSG00000136830(gene)|ensembl:ENST00000373312(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007411"(axon guidance)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032274"(gonadotropin secretion)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044029"(hypomethylation of CpG island)|go:"GO:0045296"(cadherin binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048743"(positive regulation of skeletal muscle fiber development)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|refseq:NP_001030611.1|refseq:NP_073744.2|ensembl:ENSP00000362409|ensembl:ENST00000373314|ensembl:ENSP00000362411	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:xdcw2BLz6uu0zyGi/NzvzPLrKUk9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P27361	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-73995|uniprotkb:B0LPG3|uniprotkb:A8CZ58|uniprotkb:Q8NHX1|ensembl:ENSP00000263025	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:mk03_human(display_long)|uniprotkb:ERT2(gene name synonym)|uniprotkb:MAP kinase isoform p44(gene name synonym)|uniprotkb:Microtubule-associated protein 2 kinase(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 1(gene name synonym)|uniprotkb:Insulin-stimulated MAP2 kinase(gene name synonym)|uniprotkb:p44-ERK1(gene name synonym)|uniprotkb:MAPK3(gene name)|psi-mi:MAPK3(display_short)|uniprotkb:ERK1(gene name synonym)|uniprotkb:PRKM3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001035145.1|refseq:NP_001103361.1|refseq:NP_002737.2|dip:DIP-30985N|ensembl:ENSG00000102882(gene)|ensembl:ENST00000263025(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000657"(negative regulation of apolipoprotein binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P27361|rcsb pdb:2ZOQ|rcsb pdb:4QTB|rcsb pdb:6GES|reactome:R-HSA-110056|reactome:R-HSA-112409|reactome:R-HSA-1169408|reactome:R-HSA-1295596|reactome:R-HSA-162658|reactome:R-HSA-170968|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2029482|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2871796|reactome:R-HSA-3371453|reactome:R-HSA-375165|reactome:R-HSA-444257|reactome:R-HSA-445144|reactome:R-HSA-450341|reactome:R-HSA-456926|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5663213|reactome:R-HSA-5668599|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-6811558|reactome:R-HSA-73728|reactome:R-HSA-74749|reactome:R-HSA-879415|reactome:R-HSA-881907|reactome:R-HSA-8939211|reactome:R-HSA-8940973|reactome:R-HSA-8943724|reactome:R-HSA-9627069|reactome:R-HSA-9634638|reactome:R-HSA-9635465|reactome:R-HSA-9649948|reactome:R-HSA-9652169|reactome:R-HSA-9656223|reactome:R-HSA-9664422|reactome:R-HSA-982772|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:PGxmRMz0kOsJTfdn21FBiF33YwI9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q9ULC4	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-716076|intact:EBI-1048747|uniprotkb:Q502X6|uniprotkb:B4DGY2|ensembl:ENSP00000360367|ensembl:ENSP00000500508	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:mcts1_human(display_long)|uniprotkb:MCTS1(gene name)|psi-mi:MCTS1(display_short)|uniprotkb:MCT1(gene name synonym)|uniprotkb:Multiple copies T-cell malignancies(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001131026.1|refseq:NP_054779.1|ensembl:ENSG00000232119(gene)|ensembl:ENSG00000288295(gene)|ensembl:ENST00000371317(transcript)|ensembl:ENST00000673335(transcript)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0002188"(translation reinitiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0032790"(ribosome disassembly)|go:"GO:0040008"(regulation of growth)|go:"GO:0075522"(IRES-dependent viral translational initiation)|interpro:IPR002478(PUA)|interpro:IPR004521(Uncharacterized domain 2)|interpro:IPR015947(PUA-like)|interpro:IPR016437(Translation machinery-associated RNA binding protein, predicted)|interpro:IPR041366|rcsb pdb:3R90|rcsb pdb:5ONS|rcsb pdb:5VYC|rcsb pdb:6MS4	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:g630bQeYIEobBeB8zTPwIiGlPys9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P36776	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-357448|ensembl:ENSP00000353826|intact:EBI-1054513|uniprotkb:D6W635|uniprotkb:E5KMH8|uniprotkb:P36777|uniprotkb:Q8N8K8|uniprotkb:Q9UQ95|uniprotkb:B3KPH8|uniprotkb:F5GZ27|intact:EBI-10964236	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:lonm_human(display_long)|uniprotkb:LONHs(gene name synonym)|uniprotkb:PRSS15(gene name synonym)|uniprotkb:LONP1(gene name)|psi-mi:LONP1(display_short)|uniprotkb:Lon protease-like protein(gene name synonym)|uniprotkb:Mitochondrial ATP-dependent protease Lon(gene name synonym)|uniprotkb:Serine protease 15(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001263408.1|go:"GO:0070407"(oxidation-dependent protein catabolic process)|interpro:IPR003111(Peptidase S16, lon N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR004815(Peptidase S16, ATP-dependent protease La)|interpro:IPR008268(Peptidase S16, active site)|interpro:IPR008269(Peptidase S16, lon C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR015947(PUA-like)|interpro:IPR020568|interpro:IPR027065|interpro:IPR027417|interpro:IPR027503|mint:P36776|rcsb pdb:2X36|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070182"(DNA polymerase binding)|rcsb pdb:6WYS|rcsb pdb:6WZV|rcsb pdb:6X1M|rcsb pdb:6X27|rcsb pdb:7KRZ|rcsb pdb:7KSL|rcsb pdb:7KSM|rcsb pdb:7NFY|rcsb pdb:7NG4|rcsb pdb:7NG5|rcsb pdb:7NGC|rcsb pdb:7NGF|rcsb pdb:7NGL|rcsb pdb:7NGP|rcsb pdb:7NGQ|ensembl:ENSG00000196365(gene)|ensembl:ENST00000360614(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0001018"(mitochondrial promoter sequence-specific DNA binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0009725"(response to hormone)|go:"GO:0010044"(response to aluminum ion)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|refseq:NP_001263409.1|refseq:NP_004784.2	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:quAPz1dZK2XdoE6WMjQJwFtx53o9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q9Y4L1	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-1054186|uniprotkb:Q2I204|uniprotkb:Q53H25|uniprotkb:B7Z909|uniprotkb:A8C1Z0|ensembl:ENSP00000480150|ensembl:ENSP00000486825	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:hyou1_human(display_long)|uniprotkb:150 kDa oxygen-regulated protein(gene name synonym)|uniprotkb:GRP170(gene name synonym)|uniprotkb:HYOU1(gene name)|psi-mi:HYOU1(display_short)|uniprotkb:ORP150(gene name synonym)|uniprotkb:170 kDa glucose-regulated protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001124463.1|refseq:NP_006380.1|refseq:XP_016872585.1|refseq:XP_016872586.1|ensembl:ENSG00000149428(gene)|ensembl:ENSG00000280682(gene)|ensembl:ENST00000617285(transcript)|ensembl:ENST00000630669(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005925"(focal adhesion)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0016020"(membrane)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903382"(negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:Q9Y4L1|reactome:R-HSA-3000484|reactome:R-HSA-381038|go:"GO:0005790"(smooth endoplasmic reticulum)	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:xqSFRaiiHJLNVqgh87tHx9lfnS49606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:O15347	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-2214136|uniprotkb:O95556|uniprotkb:Q6NS40|ensembl:ENSP00000359393|ensembl:ENSP00000442758	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:hmgb3_human(display_long)|uniprotkb:HMGB3(gene name)|psi-mi:HMGB3(display_short)|uniprotkb:HMG2A(gene name synonym)|uniprotkb:HMG4(gene name synonym)|uniprotkb:High mobility group protein 4(gene name synonym)|uniprotkb:High mobility group protein 2a(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001288157.1|refseq:NP_001288158.1|refseq:NP_001288160.1|refseq:NP_005333.2|ensembl:ENSG00000029993(gene)|ensembl:ENST00000325307(transcript)|ensembl:ENST00000448905(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0006310"(DNA recombination)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0032392"(DNA geometric change)|go:"GO:0045087"(innate immune response)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR017967|interpro:IPR031077|interpro:IPR036910|rcsb pdb:2EQZ|rcsb pdb:2YQI	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:3ek/VDMrZyq8bMVx0Dz3oNkjWd09606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P26583	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-1057009|uniprotkb:Q5U072|uniprotkb:D3DP37|uniprotkb:B2R4K8|ensembl:ENSP00000296503|ensembl:ENSP00000393448|ensembl:ENSP00000404912	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:hmgb2_human(display_long)|uniprotkb:HMGB2(gene name)|psi-mi:HMGB2(display_short)|uniprotkb:HMG2(gene name synonym)|uniprotkb:High mobility group protein 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001124160.1|refseq:NP_001124161.1|refseq:NP_002120.1|ensembl:ENSG00000164104(gene)|ensembl:ENST00000296503(transcript)|ensembl:ENST00000438704(transcript)|ensembl:ENST00000446922(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006265"(DNA topological change)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006325"(chromatin organization)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0007289"(spermatid nucleus differentiation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0008584"(male gonad development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032075"(positive regulation of nuclease activity)|go:"GO:0032392"(DNA geometric change)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0042056"(chemoattractant activity)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0044378"(non-sequence-specific DNA binding, bending)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045654"(positive regulation of megakaryocyte differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0072091"(regulation of stem cell proliferation)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0097100"(supercoiled DNA binding)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR017967|interpro:IPR036910|mint:P26583|reactome:R-HSA-140342	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:ACzaSeIwT3vM4ZgpCSSlzA6nd4U9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P78549	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-1049350|uniprotkb:Q1MVR1|uniprotkb:Q99566|uniprotkb:Q99794|uniprotkb:Q9BPX2|intact:EBI-28971504|ensembl:ENSP00000219066	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:nth_human(display_long)|uniprotkb:NTHL1(gene name)|psi-mi:NTHL1(display_short)|uniprotkb:NTH1(gene name synonym)|uniprotkb:OCTS3(gene name synonym)|uniprotkb:"Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase"(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENSP00000219066|ensembl:ENST00000651570|ensembl:ENSP00000498421|refseq:NP_002519.1|refseq:NP_001305122.1|refseq:NP_001305123.1|ensembl:ENSG00000065057(gene)|ensembl:ENST00000219066(transcript)|go:"GO:0000703"(oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0004519"(endonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006285"(base-excision repair, AP site formation)|go:"GO:0006296"(nucleotide-excision repair, DNA incision, 5'-to lesion)|go:"GO:0008534"(oxidized purine nucleobase lesion DNA N-glycosylase activity)|go:"GO:0019104"(DNA N-glycosylase activity)|go:"GO:0045008"(depyrimidination)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0140078"("class I DNA-(apurinic or apyrimidinic site) endonuclease activity")|interpro:IPR000445(Helix-hairpin-helix motif)|interpro:IPR003265(HhH-GPD)|interpro:IPR003651(Iron-sulphur cluster loop)|interpro:IPR004036(Endonuclease III, conserved site-2)|interpro:IPR011257(DNA glycosylase)|interpro:IPR023170|interpro:IPR030841|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110357|reactome:R-HSA-9630221|reactome:R-HSA-9630222	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:A2fztgok8Fq0ZiDHOnbUFUTSfF09606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q8NCN4	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-6380946|ensembl:ENSP00000299563|uniprotkb:Q6N015	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:rn169_human(display_long)|uniprotkb:RING-type E3 ubiquitin transferase RNF169(gene name synonym)|uniprotkb:RNF169(gene name)|psi-mi:RNF169(display_short)|uniprotkb:KIAA1991(gene name synonym)|uniprotkb:RING finger protein 169(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENSG00000166439(gene)|ensembl:ENST00000299563(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016740"(transferase activity)|go:"GO:0031491"(nucleosome binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:2000780"(negative regulation of double-strand break repair)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|mint:Q8NCN4|go:"GO:0005634"(nucleus)|rcsb pdb:5GG4|rcsb pdb:5VEY|refseq:NP_001092108.1	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:4WxnE/HtelF6yE2NC8YXDBn+sa09606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q9Y508	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-723587|uniprotkb:Q6N0B0|uniprotkb:B2RDQ9|uniprotkb:B4DWY5|uniprotkb:E1P627|ensembl:ENSP00000244061	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:rn114_human(display_long)|uniprotkb:Zinc finger protein 313(gene name synonym)|uniprotkb:RNF114(gene name)|psi-mi:RNF114(display_short)|uniprotkb:ZNF313(gene name synonym)|uniprotkb:ZNF228(gene name synonym)|uniprotkb:Zinc finger protein 228(gene name synonym)|uniprotkb:RING finger protein 114(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF114(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_061153.1|ensembl:ENSG00000124226(gene)|ensembl:ENST00000244061(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR008598(Drought induced 19)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027370|interpro:IPR034734|interpro:IPR042716|reactome:R-HSA-983168	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:R1fX8xaGuIhy/M6cLzPeyfJBf649606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q75N03	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-2832762|uniprotkb:Q9H5S6|uniprotkb:Q8TAJ4|intact:EBI-28973894|ensembl:ENSP00000401277|uniprotkb:B7ZM03	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:hakai_human(display_long)|uniprotkb:CBLL1(gene name)|psi-mi:CBLL1(display_short)|uniprotkb:HAKAI(gene name synonym)|uniprotkb:RNF188(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma-transforming sequence-like protein 1(gene name synonym)|uniprotkb:RING finger protein 188(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Hakai(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENST00000222597|ensembl:ENSP00000222597|ensembl:ENSP00000401277|ensembl:ENSG00000105879(gene)|ensembl:ENST00000440859(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080009"(mRNA methylation)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR040380|interpro:IPR040383|interpro:IPR041042|mint:Q75N03|reactome:R-HSA-8876493|refseq:NP_079090.2|refseq:NP_001271220.1	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:DqJluJuMnJy0AHXYfPKwS5s7SOM9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P22681	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P49792	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-973138|intact:EBI-28970106|ensembl:ENSP00000283195|uniprotkb:Q13074|uniprotkb:Q15280|uniprotkb:Q53TE2|uniprotkb:Q59FH7	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:rbp2_human(display_long)|uniprotkb:RANBP2(gene name)|psi-mi:RANBP2(display_short)|uniprotkb:NUP358(gene name synonym)|uniprotkb:Ran-binding protein 2(gene name synonym)|uniprotkb:Nuclear pore complex protein Nup358(gene name synonym)|uniprotkb:Nucleoporin Nup358(gene name synonym)|uniprotkb:358 kDa nucleoporin(gene name synonym)|uniprotkb:p270(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENSG00000153201(gene)|ensembl:ENST00000283195(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001975"(response to amphetamine)|go:"GO:0003723"(RNA binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005642"(annulate lamellae)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006457"(protein folding)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0016020"(membrane)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033133"(positive regulation of glucokinase activity)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044614"(nuclear pore cytoplasmic filaments)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0051642"(centrosome localization)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:1990723"(cytoplasmic periphery of the nuclear pore complex)|interpro:IPR000156(Ran Binding Protein 1)|reactome:R-HSA-168271|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019734|interpro:IPR020892|interpro:IPR022011|interpro:IPR029000|interpro:IPR036443|mint:P49792|reactome:R-HSA-168276|rcsb pdb:1RRP|reactome:R-HSA-168325|reactome:R-HSA-168333|rcsb pdb:1XKE|rcsb pdb:1Z5S|rcsb pdb:2LAS|rcsb pdb:3UIN|rcsb pdb:3UIO|rcsb pdb:3UIP|rcsb pdb:4GA0|rcsb pdb:4I9Y|rcsb pdb:4L6E|rcsb pdb:4LQW|rcsb pdb:5CLL|rcsb pdb:5CLQ|reactome:R-HSA-1169408|reactome:R-HSA-141444|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-170822|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-5663220|reactome:R-HSA-6784531|reactome:R-HSA-68877|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-180746|reactome:R-HSA-9648025|ensembl:ENSP00000283195|refseq:NP_006258.3|dip:DIP-37654N	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:KB+rjfw8djVygvDpTncA0NO2MDY9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:O75925	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-629434|uniprotkb:Q147X4|uniprotkb:Q99751|uniprotkb:Q9UN02|uniprotkb:B2RB67|uniprotkb:B3KSY9|ensembl:ENSP00000249636|intact:EBI-28970067|uniprotkb:C5J4B4	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:pias1_human(display_long)|uniprotkb:Protein inhibitor of activated STAT protein 1(gene name synonym)|uniprotkb:Gu-binding protein(gene name synonym)|uniprotkb:RNA helicase II-binding protein(gene name synonym)|uniprotkb:DEAD/H box-binding protein 1(gene name synonym)|uniprotkb:PIAS1(gene name)|psi-mi:PIAS1(display_short)|uniprotkb:DDXBP1(gene name synonym)|uniprotkb:E3 SUMO-protein transferase PIAS1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001307616.1|refseq:NP_057250.1|ensembl:ENSP00000249636|ensembl:ENST00000545237|ensembl:ENSP00000438574|ensembl:ENSG00000033800(gene)|ensembl:ENST00000249636(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008542"(visual learning)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051152"(positive regulation of smooth muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:0065004"(protein-DNA complex assembly)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR004181(Zinc finger, MIZ-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023321|interpro:IPR027226|interpro:IPR036361|interpro:IPR038654|mint:O75925|go:"GO:0042127"(regulation of cell population proliferation)|rcsb pdb:1V66|reactome:R-HSA-3108214|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-3899300|reactome:R-HSA-4090294|reactome:R-HSA-4551638|reactome:R-HSA-5696395|reactome:R-HSA-877312|refseq:XP_016878177.1|dip:DIP-5970N	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:SJB9TG4K6p8GSZwh0MNanj6cGt49606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:O00257	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-722425|uniprotkb:Q96C04|uniprotkb:Q6TPI8|uniprotkb:B1PJR7|ensembl:ENSP00000269397	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:cbx4_human(display_long)|uniprotkb:Chromobox protein homolog 4(gene name synonym)|uniprotkb:Polycomb 2 homolog(gene name synonym)|uniprotkb:CBX4(gene name)|psi-mi:CBX4(display_short)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_003646.2|dip:DIP-42042N|ensembl:ENSG00000141582(gene)|ensembl:ENST00000269397(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0031519"(PcG protein complex)|go:"GO:0032183"(SUMO binding)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035102"(PRC1 complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0061665"(SUMO ligase activity)|interpro:IPR000953(Chromo domain)|interpro:IPR016197(Chromo domain-like)|interpro:IPR017984|interpro:IPR023779|interpro:IPR023780|interpro:IPR033773|interpro:IPR043531|mint:O00257|rcsb pdb:2K28|rcsb pdb:3I8Z|rcsb pdb:5EPL|reactome:R-HSA-2559580|reactome:R-HSA-3108214|reactome:R-HSA-3899300|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4655427|reactome:R-HSA-8939243|reactome:R-HSA-8943724	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:uHX633+6nZPTNHOPmUKK+zW/b4Q9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q13627	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-1053596|uniprotkb:O60769|uniprotkb:Q92582|uniprotkb:Q92810|uniprotkb:Q9UNM5|ensembl:ENSP00000381932|ensembl:ENSP00000494544	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:dyr1a_human(display_long)|uniprotkb:Protein kinase minibrain homolog(gene name synonym)|uniprotkb:HP86(gene name synonym)|uniprotkb:Dual specificity YAK1-related kinase(gene name synonym)|uniprotkb:DYRK1A(gene name)|psi-mi:DYRK1A(display_short)|uniprotkb:DYRK(gene name synonym)|uniprotkb:MNB(gene name synonym)|uniprotkb:MNBH(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001387.2|refseq:NP_567824.1|refseq:NP_569120.1|refseq:NP_569122.1|refseq:XP_011527785.1|refseq:XP_006724039.1|refseq:XP_006724040.1|refseq:XP_006724041.1|ensembl:ENSG00000157540(gene)|ensembl:ENST00000398960(transcript)|ensembl:ENST00000644942(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007399"(nervous system development)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0015631"(tubulin binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043621"(protein self-association)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028318|interpro:IPR044131|mint:Q13627|rcsb pdb:2VX3|rcsb pdb:2WO6|rcsb pdb:3ANQ|rcsb pdb:3ANR|rcsb pdb:4AZE|rcsb pdb:4MQ1|rcsb pdb:4MQ2|rcsb pdb:4NCT|rcsb pdb:4YLJ|rcsb pdb:4YLK|rcsb pdb:4YLL|rcsb pdb:4YU2|rcsb pdb:5A3X|rcsb pdb:5A4E|rcsb pdb:5A4L|rcsb pdb:5A4Q|rcsb pdb:5A4T|rcsb pdb:5A54|rcsb pdb:5AIK|rcsb pdb:6A1G|rcsb pdb:6EIF|rcsb pdb:6EIJ|rcsb pdb:6EIL|rcsb pdb:6EIP|rcsb pdb:6EIQ|rcsb pdb:6EIR|rcsb pdb:6EIS|rcsb pdb:6EIV|rcsb pdb:6EJ4|rcsb pdb:6QU2|rcsb pdb:6S11|rcsb pdb:6S14|rcsb pdb:6S17|rcsb pdb:6S1B|rcsb pdb:6S1H|rcsb pdb:6S1I|rcsb pdb:6S1J|rcsb pdb:6T6A|rcsb pdb:6UIP|rcsb pdb:6UWY|rcsb pdb:6YF8|rcsb pdb:7A4O|rcsb pdb:7A4R|rcsb pdb:7A4S|rcsb pdb:7A4W|rcsb pdb:7A4Z|rcsb pdb:7A51|rcsb pdb:7A52|rcsb pdb:7A53|rcsb pdb:7A55|rcsb pdb:7A5B|rcsb pdb:7A5D|rcsb pdb:7A5L|rcsb pdb:7A5N|rcsb pdb:7AJ2|rcsb pdb:7AJ4|rcsb pdb:7AJ5|rcsb pdb:7AJ7|rcsb pdb:7AJ8|rcsb pdb:7AJA|rcsb pdb:7AJM|rcsb pdb:7AJS|rcsb pdb:7AJV|rcsb pdb:7AJW|rcsb pdb:7AJY|rcsb pdb:7AK2|rcsb pdb:7AKA|rcsb pdb:7AKB|rcsb pdb:7AKE|rcsb pdb:7AKL|reactome:R-HSA-1538133|rcsb pdb:6A1F|refseq:XP_016883773.1|refseq:NP_001334650.1|refseq:NP_001334651.1|dip:DIP-39750N	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:1Y5lOF9SszLsUVauAnydhzUh7fM9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P55265	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-2462104|uniprotkb:B1AQR0|uniprotkb:O15223|uniprotkb:O43859|uniprotkb:O43860|uniprotkb:Q9BYM3|uniprotkb:Q9BYM4|uniprotkb:B1AQQ9|uniprotkb:D3DV76|ensembl:ENSP00000357459	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:dsrad_human(display_long)|uniprotkb:ADAR(gene name)|psi-mi:ADAR(display_short)|uniprotkb:ADAR1(gene name synonym)|uniprotkb:DSRAD(gene name synonym)|uniprotkb:G1P1(gene name synonym)|uniprotkb:IFI4(gene name synonym)|uniprotkb:136 kDa double-stranded RNA-binding protein(gene name synonym)|uniprotkb:K88DSRBP(gene name synonym)|uniprotkb:Interferon-inducible protein 4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001020278.1|refseq:NP_001102.2|refseq:NP_001180424.1|refseq:NP_056655.2|refseq:NP_056656.2|refseq:XP_006711174.1|refseq:XP_006711175.1|refseq:XP_006711176.1|dip:DIP-29310N|ensembl:ENSG00000160710(gene)|ensembl:ENST00000368474(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002566"(somatic diversification of immune receptors via somatic mutation)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003726"(double-stranded RNA adenosine deaminase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006382"(adenosine to inosine editing)|go:"GO:0006396"(RNA processing)|go:"GO:0006397"(mRNA processing)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0008251"(tRNA-specific adenosine deaminase activity)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0016553"(base conversion or substitution editing)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0035455"(response to interferon-alpha)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044387"(negative regulation of protein kinase activity by regulation of protein phosphorylation)|go:"GO:0044530"(supraspliceosomal complex)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1900369"(negative regulation of RNA interference)|interpro:IPR002466(Adenosine deaminase/editase)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR036388|interpro:IPR036390|interpro:IPR042371|interpro:IPR044456|interpro:IPR044457|mint:P55265|rcsb pdb:1QBJ|rcsb pdb:1QGP|rcsb pdb:1XMK|rcsb pdb:2ACJ|rcsb pdb:2GXB|rcsb pdb:2L54|rcsb pdb:2MDR|rcsb pdb:3F21|rcsb pdb:3F22|rcsb pdb:3F23|rcsb pdb:3IRQ|rcsb pdb:3IRR|rcsb pdb:5ZU1|rcsb pdb:5ZUO|rcsb pdb:5ZUP|rcsb pdb:7C0I|reactome:R-HSA-75102|reactome:R-HSA-77042|reactome:R-HSA-909733|go:"GO:0051607"(defense response to virus)	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:rP/Yr/h8WLSFNdIuqWnYtZjZ9qI9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:O75937	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-1045911|uniprotkb:Q6IBA4|uniprotkb:Q8N4Z5|uniprotkb:Q9P051|uniprotkb:Q9P067|uniprotkb:D3DPM0|uniprotkb:B4DUU4|intact:EBI-28966785|ensembl:ENSP00000263697|ensembl:ENSP00000494062	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:dnjc8_human(display_long)|uniprotkb:Splicing protein spf31(gene name synonym)|uniprotkb:DNAJC8(gene name)|psi-mi:DNAJC8(display_short)|uniprotkb:SPF31(gene name synonym)|uniprotkb:HSPC315(orf name)|uniprotkb:HSPC331(orf name)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENSP00000263697|ensembl:ENSP00000494062|ensembl:ENSG00000126698(gene)|ensembl:ENSG00000285317(gene)|ensembl:ENST00000263697(transcript)|ensembl:ENST00000645856(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0045171"(intercellular bridge)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR036869|interpro:IPR042858|mint:O75937|reactome:R-HSA-72163|refseq:NP_055095.2	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:muJkeaOMc4UXHR4DPNuQeciq7PI9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q8IXB1	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-2949763|ensembl:ENSP00000264065|uniprotkb:Q53QT7|uniprotkb:Q6UWZ6|uniprotkb:Q96K44|uniprotkb:Q8NC82|uniprotkb:Q86T61|uniprotkb:Q9NSY6|uniprotkb:Q17RJ6|uniprotkb:Q8TD87|uniprotkb:Q96K54|uniprotkb:Q96K38|uniprotkb:Q4ZG06|uniprotkb:Q3B7W8	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:djc10_human(display_long)|uniprotkb:DNAJC10(gene name)|psi-mi:DNAJC10(display_short)|uniprotkb:ERDJ5(gene name synonym)|uniprotkb:Macrothioredoxin(gene name synonym)|uniprotkb:UNQ495/PRO1012(orf name)|uniprotkb:Endoplasmic reticulum DNA J domain-containing protein 5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENSG00000077232(gene)|ensembl:ENST00000264065(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0015036"(disulfide oxidoreductase activity)|go:"GO:0016020"(membrane)|go:"GO:0016671"(oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0051087"(chaperone binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017937|interpro:IPR021170|interpro:IPR035673|interpro:IPR035674|interpro:IPR036249|interpro:IPR036869|mint:Q8IXB1|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|refseq:NP_061854.1|refseq:NP_001258510.1|dip:DIP-48947N	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:sD/pp49jws0LrBjwCxQmZqzfR9U9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q9NR28	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-517508|uniprotkb:Q96LV0|uniprotkb:Q9BT11|uniprotkb:Q9HAV6|uniprotkb:B2RDQ0|ensembl:ENSP00000442360|ensembl:ENSP00000499058|uniprotkb:Q6W3F3	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:dbloh_human(display_long)|uniprotkb:Second mitochondria-derived activator of caspase(gene name synonym)|uniprotkb:Direct IAP-binding protein with low pI(gene name synonym)|uniprotkb:DIABLO(gene name)|psi-mi:DIABLO(display_short)|uniprotkb:SMAC(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001265231.1|refseq:NP_001265232.1|refseq:NP_001265233.1|refseq:NP_001265271.1|refseq:NP_620308.1|refseq:NP_063940.1|ensembl:ENST00000464942(transcript)|ensembl:ENSG00000184047(gene)|ensembl:ENST00000650715(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR009062(Second mitochondria-derived activator of caspase/direct IAP-binding protein with low PI-like)|interpro:IPR015142(Second mitochondria-derived activator of caspase/Direct IAP-binding protein with low PI)|rcsb pdb:1FEW|dip:DIP-27627N|rcsb pdb:1G3F|rcsb pdb:1G73|rcsb pdb:1OXQ|rcsb pdb:1TW6|rcsb pdb:1XB0|rcsb pdb:1XB1|rcsb pdb:3D9U|rcsb pdb:3UIH|rcsb pdb:3UIJ|rcsb pdb:4TX5|rcsb pdb:6JX6|reactome:R-HSA-111457|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-111469|reactome:R-HSA-9627069	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:PkdIVYOS6o8pglwOXzsyD/frCqI9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P51397	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-719219|uniprotkb:Q9BUC9|uniprotkb:Q6FGC3|ensembl:ENSP00000230895	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:dap1_human(display_long)|uniprotkb:DAP(gene name)|psi-mi:DAP(display_short)|uniprotkb:DAP1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_004385.1|ensembl:ENSG00000112977(gene)|ensembl:ENST00000230895(transcript)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070513"(death domain binding)|go:"GO:0097190"(apoptotic signaling pathway)|interpro:IPR024130|refseq:NP_001278892.1	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:UxbkczJJPYpZuJSyfbDeREm/b6o9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P14854	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-1047480|uniprotkb:Q6IBL4|uniprotkb:B2R5C9|ensembl:ENSP00000376037|ensembl:ENSP00000466818|ensembl:ENSP00000497926	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:cx6b1_human(display_long)|uniprotkb:COX6B1(gene name)|psi-mi:COX6B1(display_short)|uniprotkb:COX6B(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit VIb isoform 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001854.1|ensembl:ENSG00000126267(gene)|ensembl:ENST00000392201(transcript)|ensembl:ENST00000592141(transcript)|ensembl:ENST00000649813(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0021762"(substantia nigra development)|go:"GO:0045277"(respiratory chain complex IV)|interpro:IPR003213(Cytochrome c oxidase, subunit VIb)|interpro:IPR036549|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:YuBPGRO9+EC9fWz+mWALa2DyZL89606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P00167	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-1047284|uniprotkb:A8MV91|uniprotkb:Q6IB14|uniprotkb:F8WEU4|ensembl:ENSP00000341625	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:cyb5_human(display_long)|uniprotkb:CYB5A(gene name)|psi-mi:CYB5A(display_short)|uniprotkb:CYB5(gene name synonym)|uniprotkb:Microsomal cytochrome b5 type A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001905.1|refseq:NP_683725.1|refseq:XP_011524137.1|refseq:NP_001177736.1|go:"GO:0005829"(cytosol)|go:"GO:0009055"(electron transfer activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0020037"(heme binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR018506|interpro:IPR036400|rcsb pdb:2I96|reactome:R-HSA-196836|reactome:R-HSA-9609523|ensembl:ENSG00000166347(gene)|ensembl:ENST00000340533(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:nZ/xafhkGjHBGCIWhtvBD1mtVSQ9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:O60583	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-2836757|uniprotkb:Q5I1Y0|uniprotkb:A8KA48|uniprotkb:Q29R66|uniprotkb:Q53SR4|uniprotkb:O60582|uniprotkb:D3DP73|uniprotkb:D3DP74|ensembl:ENSP00000264157	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:ccnt2_human(display_long)|uniprotkb:CCNT2(gene name)|psi-mi:CCNT2(display_short)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001232.1|refseq:NP_490595.1|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019085"(early viral transcription)|go:"GO:0019086"(late viral transcription)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051301"(cell division)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0097322"(7SK snRNA binding)|ensembl:ENSG00000082258(gene)|ensembl:ENST00000264157(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR028862|interpro:IPR036915|interpro:IPR043198|mint:O60583|rcsb pdb:2IVX|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-2173796|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|interpro:IPR013763(Cyclin-related)	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:v1mUPCNA+Plg8UioUhIj1LL52fI9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P50750	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-1383449|uniprotkb:Q5JU24|uniprotkb:Q5JU25|uniprotkb:Q5U006|uniprotkb:Q96TF1|ensembl:ENSP00000362361	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:cdk9_human(display_long)|uniprotkb:CDK9(gene name)|psi-mi:CDK9(display_short)|uniprotkb:CDC2L4(gene name synonym)|uniprotkb:Cell division protein kinase 9(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PITALRE(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 4(gene name synonym)|uniprotkb:C-2K(gene name synonym)|uniprotkb:TAK(gene name synonym)|uniprotkb:Tat-associated kinase complex catalytic subunit(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001252.1|dip:DIP-29016N|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000136807(gene)|ensembl:ENST00000373264(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0031297"(replication fork processing)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070691"(P-TEFb complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1903839"(positive regulation of mRNA 3'-UTR binding)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P50750|rcsb pdb:1PF6|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:XSEmM4b5tp/WCJCJxnQYyP0stvM9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q9NYV4	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-1055431|uniprotkb:A7E2B2|uniprotkb:O94978|uniprotkb:B4DYX4|uniprotkb:B9EIQ6|ensembl:ENSP00000398880	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:cdk12_human(display_long)|uniprotkb:Cdc2-related kinase, arginine/serine-rich(gene name synonym)|uniprotkb:CDK12(gene name)|psi-mi:CDK12(display_short)|uniprotkb:CRK7(gene name synonym)|uniprotkb:KIAA0904(gene name synonym)|uniprotkb:CRKRS(gene name synonym)|uniprotkb:Cell division cycle 2-related protein kinase 7(gene name synonym)|uniprotkb:Cell division protein kinase 12(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_055898.1|refseq:NP_057591.2|ensembl:ENST00000430627|ensembl:ENSP00000407720|ensembl:ENSP00000398880|ensembl:ENSG00000167258(gene)|ensembl:ENST00000447079(transcript)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0002944"(cyclin K-CDK12 complex)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006397"(mRNA processing)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019908"(nuclear cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0030332"(cyclin binding)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0043405"(regulation of MAP kinase activity)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:4CXA|rcsb pdb:4NST|rcsb pdb:4UN0|rcsb pdb:5ACB|rcsb pdb:6B3E|rcsb pdb:6CKX|rcsb pdb:6TD3|rcsb pdb:7NXK|reactome:R-HSA-6796648|dip:DIP-39768N	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:qffna20nodTj1PmlReV/ACpVcqs9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q9UQ88	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-373024|uniprotkb:O95227|uniprotkb:O95228|uniprotkb:O96012|uniprotkb:Q12821|uniprotkb:Q12853|uniprotkb:Q12854|uniprotkb:Q5QPR0|uniprotkb:Q5QPR1|uniprotkb:Q5QPR2|uniprotkb:Q9UBC4|uniprotkb:Q9UBI3|uniprotkb:Q9UEI1|uniprotkb:Q9UEI2|uniprotkb:Q9UP53|uniprotkb:Q9UP54|uniprotkb:Q9UP55|uniprotkb:Q9UP56|uniprotkb:Q9UQ86|uniprotkb:Q9UQ87|uniprotkb:Q9UQ89|uniprotkb:Q2TAJ0|ensembl:ENSP00000367900	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:cd11a_human(display_long)|uniprotkb:CDK11A(gene name)|psi-mi:CDK11A(display_short)|uniprotkb:PITSLREB(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 2(gene name synonym)|uniprotkb:Galactosyltransferase-associated protein kinase p58/GTA(gene name synonym)|uniprotkb:CDC2L2(gene name synonym)|uniprotkb:CDC2L3(gene name synonym)|uniprotkb:PITSLRE serine/threonine-protein kinase CDC2L2(gene name synonym)|uniprotkb:Cell division protein kinase 11A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_076916.2|refseq:NP_277071.2|refseq:NP_001300825.1|refseq:NP_001300911.1|ensembl:ENSG00000008128(gene)|ensembl:ENST00000378633(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|mint:Q9UQ88|reactome:R-HSA-380270	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:h30ee1oqCuzFkWhpX9dsmJFl9Y09606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P06493	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-444308|ensembl:ENSP00000378699|uniprotkb:O60764|uniprotkb:C9J497|uniprotkb:A8K7C4	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:cdk1_human(display_long)|uniprotkb:p34 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 1(gene name synonym)|uniprotkb:CDK1(gene name)|psi-mi:CDK1(display_short)|uniprotkb:CDC2(gene name synonym)|uniprotkb:Cell division control protein 2 homolog(gene name synonym)|uniprotkb:CDC28A(gene name synonym)|uniprotkb:CDKN1(gene name synonym)|uniprotkb:P34CDC2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007344"(pronuclear fusion)|go:"GO:0007569"(cell aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0014038"(regulation of Schwann cell differentiation)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014075"(response to amine)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030332"(cyclin binding)|go:"GO:0030496"(midbody)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0035173"(histone kinase activity)|go:"GO:0006260"(DNA replication)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0048511"(rhythmic process)|go:"GO:0048678"(response to axon injury)|go:"GO:0051301"(cell division)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0042493"|go:"GO:0072686"(mitotic spindle)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0097125"(cyclin B1-CDK1 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1905448"(positive regulation of mitochondrial ATP synthesis coupled electron transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P06493|rcsb pdb:1LC9|rcsb pdb:4Y72|rcsb pdb:4YC3|rcsb pdb:4YC6|rcsb pdb:5HQ0|rcsb pdb:5LQF|rcsb pdb:6GU2|rcsb pdb:6GU3|rcsb pdb:6GU4|rcsb pdb:6GU6|go:"GO:0042752"(regulation of circadian rhythm)|rcsb pdb:6GU7|rcsb pdb:6TWN|reactome:R-HSA-110056|reactome:R-HSA-113507|reactome:R-HSA-1362300|reactome:R-HSA-162658|reactome:R-HSA-170145|reactome:R-HSA-174048|reactome:R-HSA-174184|reactome:R-HSA-176408|reactome:R-HSA-176412|reactome:R-HSA-176417|reactome:R-HSA-2299718|reactome:R-HSA-2465910|reactome:R-HSA-2500257|reactome:R-HSA-2514853|reactome:R-HSA-2565942|reactome:R-HSA-2980767|reactome:R-HSA-2995383|reactome:R-HSA-3301854|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-4419969|reactome:R-HSA-5620912|reactome:R-HSA-5687128|reactome:R-HSA-5689896|reactome:R-HSA-6804114|reactome:R-HSA-6804757|reactome:R-HSA-68875|reactome:R-HSA-69205|reactome:R-HSA-69273|reactome:R-HSA-69478|reactome:R-HSA-75035|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8878166|ensembl:ENSG00000170312(gene)|ensembl:ENST00000395284(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001618"(virus receptor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|refseq:NP_001777.1|refseq:NP_203698.1|refseq:XP_005270360.1|refseq:NP_001307847.1|dip:DIP-35N	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:8geyXVp0Rpm8sG8I76/XgWsZ4JA9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:O00244	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-10179267|uniprotkb:Q2M1R6|uniprotkb:A8KAJ8|uniprotkb:D3DQI2|uniprotkb:Q56AP3|ensembl:ENSP00000316854|ensembl:ENSP00000429814|ensembl:ENSP00000430598	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:atox1_human(display_long)|uniprotkb:ATOX1(gene name)|psi-mi:ATOX1(display_short)|uniprotkb:HAH1(gene name synonym)|uniprotkb:Metal transport protein ATX1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_004036.1|ensembl:ENSG00000177556(gene)|ensembl:ENST00000313115(transcript)|ensembl:ENST00000522710(transcript)|ensembl:ENST00000524142(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0006825"(copper ion transport)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0016530"(metallochaperone activity)|go:"GO:0016531"(copper chaperone activity)|go:"GO:0032767"(copper-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051117"(ATPase binding)|go:"GO:0060003"(copper ion export)|go:"GO:1903136"(cuprous ion binding)|interpro:IPR006121(Heavy metal transport/detoxification protein)|interpro:IPR017969|interpro:IPR036163|rcsb pdb:1FE0|rcsb pdb:1FE4|rcsb pdb:1FEE|rcsb pdb:1TL4|rcsb pdb:1TL5|rcsb pdb:2K1R|rcsb pdb:2LQ9|rcsb pdb:3CJK|rcsb pdb:3IWL|rcsb pdb:3IWX|rcsb pdb:4QOT|rcsb pdb:4YDX|rcsb pdb:4YEA|rcsb pdb:5F0W|rcsb pdb:5T7L|reactome:R-HSA-3299685|reactome:R-HSA-6803544	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:+aoVGSDXbzrq71ZKogtE9LHtHss9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:O75131	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-718988|uniprotkb:Q8IYA1|uniprotkb:A8KA47|ensembl:ENSP00000477590	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:cpne3_human(display_long)|uniprotkb:Copine III(gene name synonym)|uniprotkb:CPNE3(gene name)|psi-mi:CPNE3(display_short)|uniprotkb:CPN3(gene name synonym)|uniprotkb:KIAA0636(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_003900.1|refseq:XP_005251150.1|ensembl:ENSG00000085719(gene)|ensembl:ENST00000517490(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071363"(cellular response to growth factor stimulus)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR010734(Copine)|interpro:IPR035892|interpro:IPR036465|interpro:IPR037768|mint:O75131|reactome:R-HSA-1483206|reactome:R-HSA-6798695|refseq:XP_016869434.1	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:75lb/sKHpJYCwCLIq973pzNMfzw9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P00751	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-1223668|uniprotkb:Q53F89|uniprotkb:O15006|uniprotkb:Q29944|uniprotkb:Q5ST50|uniprotkb:Q96HX6|uniprotkb:Q9BTF5|uniprotkb:Q9BX92|uniprotkb:B0QZQ6|uniprotkb:Q5JP67|ensembl:ENSP00000382862|ensembl:ENSP00000388352|ensembl:ENSP00000389604|ensembl:ENSP00000391902|ensembl:ENSP00000411474|ensembl:ENSP00000411515|ensembl:ENSP00000413351|ensembl:ENSP00000414341|ensembl:ENSP00000414889|ensembl:ENSP00000416561|ensembl:ENSP00000401719	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:cfab_human(display_long)|uniprotkb:CFB(gene name)|psi-mi:CFB(display_short)|uniprotkb:BF(gene name synonym)|uniprotkb:BFD(gene name synonym)|uniprotkb:C3/C5 convertase(gene name synonym)|uniprotkb:Properdin factor B(gene name synonym)|uniprotkb:Glycine-rich beta glycoprotein(gene name synonym)|uniprotkb:PBF2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001701.2|dip:DIP-38319N|ensembl:ENSG00000239754(gene)|ensembl:ENSG00000241253(gene)|ensembl:ENSG00000241534(gene)|ensembl:ENSG00000242335(gene)|ensembl:ENSG00000243570(gene)|ensembl:ENSG00000243649(gene)|ensembl:ENST00000399981(transcript)|ensembl:ENST00000417261(transcript)|ensembl:ENST00000419411(transcript)|ensembl:ENST00000419920(transcript)|ensembl:ENST00000424727(transcript)|ensembl:ENST00000425368(transcript)|ensembl:ENST00000426239(transcript)|ensembl:ENST00000427888(transcript)|ensembl:ENST00000433503(transcript)|ensembl:ENST00000436692(transcript)|ensembl:ENST00000455591(transcript)|go:"GO:0001848"(complement binding)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR011360(Complement B/C2)|interpro:IPR018114|interpro:IPR028341|interpro:IPR033116|interpro:IPR035976|interpro:IPR036465|mint:P00751|rcsb pdb:1DLE|rcsb pdb:1Q0P|rcsb pdb:1RRK|rcsb pdb:1RS0|rcsb pdb:1RTK|rcsb pdb:2OK5|rcsb pdb:2WIN|rcsb pdb:2XWB|rcsb pdb:2XWJ|rcsb pdb:3HRZ|rcsb pdb:3HS0|rcsb pdb:6QSW|rcsb pdb:6QSX|rcsb pdb:6RAV|rcsb pdb:6RUR|rcsb pdb:6RUV|rcsb pdb:6T8U|rcsb pdb:6T8V|rcsb pdb:6T8W|rcsb pdb:7JTN|rcsb pdb:7JTQ|reactome:R-HSA-173736|reactome:R-HSA-174577|reactome:R-HSA-977606	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:A6O1R+3K/DVzxKoEh2sLjEmDY/s9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P04637	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-366083|uniprotkb:Q15086|uniprotkb:Q15087|uniprotkb:Q15088|uniprotkb:Q16535|uniprotkb:Q16807|uniprotkb:Q16808|uniprotkb:Q16809|uniprotkb:Q16810|uniprotkb:Q16811|uniprotkb:Q16848|uniprotkb:Q86UG1|uniprotkb:Q8J016|uniprotkb:Q99659|uniprotkb:Q9BTM4|uniprotkb:Q9HAQ8|uniprotkb:Q9NP68|uniprotkb:Q9NPJ2|uniprotkb:Q9NZD0|uniprotkb:Q9UBI2|uniprotkb:Q9UQ61|ensembl:ENSP00000269305|ensembl:ENSP00000391478|intact:EBI-28980681|uniprotkb:Q2XN98|uniprotkb:Q3LRW1|uniprotkb:Q3LRW2|uniprotkb:Q3LRW3|uniprotkb:Q3LRW4|uniprotkb:Q3LRW5	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:p53_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)|uniprotkb:Phosphoprotein p53(gene name synonym)|uniprotkb:Antigen NY-CO-13(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001263624.1|refseq:NP_001263625.1|ensembl:ENSG00000141510(gene)|ensembl:ENST00000269305(transcript)|ensembl:ENST00000445888(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0043621"(protein self-association)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009651"(response to salt stress)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|interpro:IPR040926|rcsb pdb:2ATA|rcsb pdb:2B3G|rcsb pdb:2BIM|rcsb pdb:2BIN|rcsb pdb:2BIO|rcsb pdb:2BIP|rcsb pdb:2AHI|rcsb pdb:2BIQ|rcsb pdb:2F1X|rcsb pdb:2FEJ|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2GS0|rcsb pdb:2H1L|rcsb pdb:2H2D|rcsb pdb:2H2F|rcsb pdb:2H4F|rcsb pdb:2H4H|rcsb pdb:2H4J|rcsb pdb:2H59|rcsb pdb:2J0Z|rcsb pdb:2J10|rcsb pdb:2J11|rcsb pdb:2J1W|rcsb pdb:2J1X|rcsb pdb:2J1Y|rcsb pdb:2J1Z|rcsb pdb:2J20|rcsb pdb:2J21|rcsb pdb:2K8F|rcsb pdb:2L14|rcsb pdb:2LY4|rcsb pdb:2MEJ|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:2MWY|rcsb pdb:2MZD|rcsb pdb:2OCJ|rcsb pdb:2PCX|rcsb pdb:1A1U|rcsb pdb:1AIE|rcsb pdb:1C26|rcsb pdb:1DT7|rcsb pdb:1GZH|rcsb pdb:1H26|rcsb pdb:1HS5|rcsb pdb:1JSP|rcsb pdb:1KZY|rcsb pdb:1MA3|rcsb pdb:1OLG|rcsb pdb:1OLH|rcsb pdb:1PES|rcsb pdb:1PET|mint:P04637|rcsb pdb:1SAE|rcsb pdb:1SAF|rcsb pdb:1SAK|rcsb pdb:1SAL|rcsb pdb:1TSR|rcsb pdb:1TUP|rcsb pdb:1UOL|rcsb pdb:1XQH|rcsb pdb:1YC5|rcsb pdb:1YCQ|rcsb pdb:1YCR|rcsb pdb:1YCS|rcsb pdb:2AC0|rcsb pdb:2ADY|refseq:NP_000537.3|refseq:NP_001119584.1|refseq:NP_001119585.1|refseq:NP_001119586.1|refseq:NP_001119587.1|refseq:NP_001119588.1|refseq:NP_001119589.1|rcsb pdb:2RUK|rcsb pdb:2VUK|rcsb pdb:3Q06|rcsb pdb:2WGX|rcsb pdb:2X0U|rcsb pdb:2X0V|rcsb pdb:2X0W|rcsb pdb:2XWR|rcsb pdb:2YBG|rcsb pdb:2YDR|rcsb pdb:2Z5S|rcsb pdb:2Z5T|rcsb pdb:3SAK|rcsb pdb:3D05|rcsb pdb:3D06|rcsb pdb:3D07|rcsb pdb:3D08|rcsb pdb:3D09|rcsb pdb:3D0A|rcsb pdb:3DAB|rcsb pdb:3DAC|rcsb pdb:3IGK|rcsb pdb:3IGL|rcsb pdb:3KMD|rcsb pdb:3TG5|rcsb pdb:3KZ8|rcsb pdb:3LW1|rcsb pdb:3OQ5|rcsb pdb:3PDH|rcsb pdb:3Q01|rcsb pdb:3Q05|rcsb pdb:3TS8|rcsb pdb:3ZME|rcsb pdb:4AGM|rcsb pdb:4AGN|rcsb pdb:4AGO|rcsb pdb:4AGP|rcsb pdb:4AGQ|rcsb pdb:4BUZ|rcsb pdb:4BV2|rcsb pdb:4HFZ|rcsb pdb:4HJE|rcsb pdb:4IBQ|rcsb pdb:4IBS|rcsb pdb:4IBT|rcsb pdb:4IBU|rcsb pdb:4IBV|rcsb pdb:4IBW|rcsb pdb:4IBY|rcsb pdb:4IBZ|rcsb pdb:4IJT|rcsb pdb:4KVP|rcsb pdb:4LO9|rcsb pdb:4LOE|rcsb pdb:4LOF|rcsb pdb:4MZI|rcsb pdb:4MZR|rcsb pdb:4QO1|rcsb pdb:4RP6|rcsb pdb:4RP7|rcsb pdb:4X34|rcsb pdb:4XR8|rcsb pdb:4ZZJ|rcsb pdb:5A7B|rcsb pdb:5AB9|rcsb pdb:5ABA|rcsb pdb:4AGL|rcsb pdb:5AOI|rcsb pdb:5AOJ|rcsb pdb:5AOK|rcsb pdb:5AOL|rcsb pdb:5AOM|rcsb pdb:6XRE|rcsb pdb:7BWN|rcsb pdb:7DHY|rcsb pdb:7DHZ|rcsb pdb:7EL4|reactome:R-HSA-111448|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-2559586|reactome:R-HSA-3232118|reactome:R-HSA-349425|reactome:R-HSA-390471|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5693565|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-6804116|reactome:R-HSA-6804754|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-69473|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8853884|reactome:R-HSA-8941855|reactome:R-HSA-8943724|reactome:R-HSA-983231|rcsb pdb:5ECG|rcsb pdb:5G4M|rcsb pdb:5G4N|rcsb pdb:5BUA|rcsb pdb:5G4O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5LAP|rcsb pdb:5LGY|rcsb pdb:5MCT|rcsb pdb:5MCU|rcsb pdb:5MCV|rcsb pdb:5MCW|rcsb pdb:5MF7|rcsb pdb:5MG7|rcsb pdb:5MHC|rcsb pdb:5MOC|rcsb pdb:5O1A|rcsb pdb:5O1B|rcsb pdb:5O1C|rcsb pdb:5O1D|rcsb pdb:5O1E|rcsb pdb:5O1F|rcsb pdb:5O1G|rcsb pdb:5O1H|rcsb pdb:5O1I|rcsb pdb:5OL0|rcsb pdb:5UN8|rcsb pdb:5XZC|rcsb pdb:6FF9|rcsb pdb:6FJ5|rcsb pdb:6GGA|rcsb pdb:6GGB|rcsb pdb:6GGC|rcsb pdb:6GGD|rcsb pdb:6GGE|rcsb pdb:6GGF|rcsb pdb:6LHD|rcsb pdb:6R5L|rcsb pdb:6RJZ|rcsb pdb:6RK8|rcsb pdb:6RKI|rcsb pdb:6RKK|rcsb pdb:6RKM|rcsb pdb:6RL3|rcsb pdb:6RL4|rcsb pdb:6RL6|rcsb pdb:6RM5|rcsb pdb:6RM7|rcsb pdb:6RWH|rcsb pdb:6RWI|rcsb pdb:6RWS|rcsb pdb:6RWU|rcsb pdb:6RX2|rcsb pdb:6RZ3|rcsb pdb:6S39|rcsb pdb:6S40|rcsb pdb:6S9Q|rcsb pdb:6SHZ|rcsb pdb:6SI0|rcsb pdb:6SI1|rcsb pdb:6SI2|rcsb pdb:6SI3|rcsb pdb:6SI4|rcsb pdb:6SIN|rcsb pdb:6SIO|rcsb pdb:6SIP|rcsb pdb:6SIQ|rcsb pdb:6SL6|rcsb pdb:6SLV|rcsb pdb:6T58|rcsb pdb:6V4F|rcsb pdb:6V4H|rcsb pdb:6VQO|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6S3C|ensembl:ENSP00000269305|ensembl:ENST00000420246|ensembl:ENSP00000391127|ensembl:ENSP00000391478|ensembl:ENST00000455263|ensembl:ENSP00000398846|ensembl:ENST00000504290|ensembl:ENSP00000484409|ensembl:ENST00000504937|ensembl:ENSP00000481179|ensembl:ENST00000510385|ensembl:ENSP00000478499|ensembl:ENST00000610292|ensembl:ENSP00000478219|ensembl:ENST00000610538|ensembl:ENSP00000480868|ensembl:ENST00000619485|ensembl:ENSP00000482537|ensembl:ENST00000620739|ensembl:ENSP00000481638|ensembl:ENST00000622645|ensembl:ENSP00000482222|refseq:NP_001119590.1|refseq:NP_001263626.1|refseq:NP_001263627.1|refseq:NP_001263628.1|refseq:NP_001263689.1|refseq:NP_001263690.1|dip:DIP-368N	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:fGN3kSCGIpi/D6d/X5kaB0Xu8/k9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P17655	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-1028956|uniprotkb:Q16738|uniprotkb:Q6PJT3|uniprotkb:Q8WU26|uniprotkb:Q9HBB1|uniprotkb:A6NDG7|ensembl:ENSP00000295006|uniprotkb:B7ZA96|uniprotkb:E7ES58	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:can2_human(display_long)|uniprotkb:CAPN2(gene name)|psi-mi:CAPN2(display_short)|uniprotkb:CANPL2(gene name synonym)|uniprotkb:Calpain-2 large subunit(gene name synonym)|uniprotkb:Calcium-activated neutral proteinase 2(gene name synonym)|uniprotkb:Calpain M-type(gene name synonym)|uniprotkb:Millimolar-calpain(gene name synonym)|uniprotkb:Calpain large polypeptide L2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001139540.1|refseq:NP_001739.2|ensembl:ENSG00000162909(gene)|ensembl:ENST00000295006(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001824"(blastocyst development)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007520"(myoblast fusion)|go:"GO:0007565"(female pregnancy)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031143"(pseudopodium)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0005634"(nucleus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:2001247"(positive regulation of phosphatidylcholine biosynthetic process)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR001300(Peptidase C2, calpain)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005764"(lysosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022682|interpro:IPR022683|interpro:IPR022684|interpro:IPR029539|interpro:IPR033883|interpro:IPR036213|interpro:IPR038765|interpro:IPR042736|mint:P17655|rcsb pdb:1KFU|rcsb pdb:1KFX|rcsb pdb:2NQA|reactome:R-HSA-1474228|reactome:R-HSA-8862803|interpro:IPR002048(Calcium-binding EF-hand)	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:r60XX66kihGVLaa9888soeXjc0M9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P07384	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-1542113|uniprotkb:Q2TTR0|uniprotkb:Q6DHV4|ensembl:ENSP00000279247|ensembl:ENSP00000431686|ensembl:ENSP00000431984|ensembl:ENSP00000434176|ensembl:ENSP00000435272	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:can1_human(display_long)|uniprotkb:CAPN1(gene name)|psi-mi:CAPN1(display_short)|uniprotkb:CANPL1(gene name synonym)|uniprotkb:Calpain-1 large subunit(gene name synonym)|uniprotkb:Calcium-activated neutral proteinase 1(gene name synonym)|uniprotkb:Calpain mu-type(gene name synonym)|uniprotkb:Micromolar-calpain(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 30 protein(gene name synonym)|uniprotkb:PIG30(orf name)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:XP_006718761.1|refseq:NP_001185797.1|refseq:NP_001185798.1|refseq:NP_005177.2|refseq:XP_011543594.1|ensembl:ENSG00000014216(gene)|ensembl:ENST00000279247(transcript)|ensembl:ENST00000524773(transcript)|ensembl:ENST00000527323(transcript)|ensembl:ENST00000533129(transcript)|ensembl:ENST00000533820(transcript)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0060056"(mammary gland involution)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097264"(self proteolysis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000310"(regulation of NMDA receptor activity)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR001300(Peptidase C2, calpain)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022682|interpro:IPR022683|interpro:IPR022684|interpro:IPR029643|interpro:IPR033883|interpro:IPR036213|interpro:IPR038765|mint:P07384|rcsb pdb:1ZCM|rcsb pdb:2ARY|reactome:R-HSA-1474228|reactome:R-HSA-6798695|reactome:R-HSA-6809371|reactome:R-HSA-8862803	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:hLf5vu04E7/yonXBb9VIZThbcxk9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P62158	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-397435|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q13942|uniprotkb:Q53S29|uniprotkb:Q61379|uniprotkb:Q61380|uniprotkb:Q96HK3|uniprotkb:P0DP25|uniprotkb:P0DP24|uniprotkb:P0DP23	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:calm_human(display_long)|uniprotkb:CALM1(gene name)|psi-mi:CALM1(display_short)|uniprotkb:CALM(gene name synonym)|uniprotkb:CAM(gene name synonym)|uniprotkb:CAM1(gene name synonym)|uniprotkb:CALM2(gene name)|psi-mi:CALM2(display_short)|uniprotkb:CAMB(gene name synonym)|uniprotkb:CALM3(gene name)|psi-mi:CALM3(display_short)|uniprotkb:CAM3(gene name synonym)|uniprotkb:CAMC(gene name synonym)|uniprotkb:CAMIII(gene name synonym)|uniprotkb:CAM2(gene name synonym)|uniprotkb:CALML2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	rcsb pdb:3SUI|rcsb pdb:2LGF|rcsb pdb:2LQC|rcsb pdb:2LQP|rcsb pdb:2Y4V|rcsb pdb:4JQ0|rcsb pdb:4LZX|rcsb pdb:4M1L|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|rcsb pdb:3J41|rcsb pdb:2LL6|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0030017"(sarcomere)|go:"GO:0030801"(obsolete positive regulation of cyclic nucleotide metabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|rcsb pdb:2LV6|rcsb pdb:2N6A|refseq:NP_001734.1|refseq:NP_005175.2|refseq:NP_008819.1|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005876"(spindle microtubule)|go:"GO:0000922"(spindle pole)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005980"(glycogen catabolic process)|go:"GO:0006936"(muscle contraction)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0002576"(platelet degranulation)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|rcsb pdb:1AJI|rcsb pdb:1CDL|rcsb pdb:1CLL|rcsb pdb:1CTR|rcsb pdb:1IWQ|rcsb pdb:1J7O|rcsb pdb:1J7P|rcsb pdb:1K90|rcsb pdb:1K93|rcsb pdb:1L7Z|rcsb pdb:1LVC|rcsb pdb:1NKF|rcsb pdb:1PK0|rcsb pdb:1S26|rcsb pdb:1SK6|rcsb pdb:1SW8|rcsb pdb:1WRZ|rcsb pdb:1XFU|rcsb pdb:1XFV|rcsb pdb:1XFW|rcsb pdb:1XFX|rcsb pdb:1XFY|rcsb pdb:1XFZ|rcsb pdb:1Y6W|rcsb pdb:1YR5|rcsb pdb:1YRT|rcsb pdb:1YRU|rcsb pdb:1ZOT|rcsb pdb:1ZUZ|rcsb pdb:2BE6|rcsb pdb:2F3Y|rcsb pdb:2F3Z|rcsb pdb:2HF5|rcsb pdb:2I08|rcsb pdb:2JZI|rcsb pdb:2K0E|rcsb pdb:2K0F|rcsb pdb:2K0J|rcsb pdb:2K61|rcsb pdb:2KNE|rcsb pdb:2KUG|rcsb pdb:2KUH|rcsb pdb:2L53|rcsb pdb:2L7L|rcsb pdb:2R28|rcsb pdb:2V01|rcsb pdb:2V02|rcsb pdb:2VAY|rcsb pdb:2W73|rcsb pdb:2WEL|rcsb pdb:2X0G|rcsb pdb:3BYA|rcsb pdb:3DVE|rcsb pdb:3DVJ|rcsb pdb:3DVK|rcsb pdb:3DVM|rcsb pdb:3EWT|rcsb pdb:3EWV|rcsb pdb:3G43|rcsb pdb:3HR4|rcsb pdb:3O77|rcsb pdb:3O78|rcsb pdb:3OXQ|rcsb pdb:3UCT|rcsb pdb:3UCW|rcsb pdb:3UCY|rcsb pdb:4DCK|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0000165"(MAPK cascade)|rcsb pdb:2M0J|rcsb pdb:2M0K|rcsb pdb:4UMO|rcsb pdb:4V0C|go:"GO:0031982"(vesicle)|rcsb pdb:4Q5U|rcsb pdb:4UPU|reactome:R-HSA-2672351|reactome:R-HSA-418359|reactome:R-HSA-425561|reactome:R-HSA-5576892|reactome:R-HSA-5578775|reactome:R-HSA-936837|refseq:NP_001292555.1|rcsb pdb:4OVN|rcsb pdb:5COC|go:"GO:0021762"(substantia nigra development)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:4BW7|rcsb pdb:4BW8|rcsb pdb:4L79|rcsb pdb:5DBR|rcsb pdb:4DJC|rcsb pdb:2M55|rcsb pdb:2LL7|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0001975"(response to amphetamine)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030426"(growth cone)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051412"(response to corticosterone)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|rcsb pdb:2N77|go:"GO:0032991"(protein-containing complex)|go:"GO:0006479"(protein methylation)|go:"GO:0014069"(postsynaptic density)|rcsb pdb:5DSU|reactome:R-HSA-8876725|rcsb pdb:4GOW|rcsb pdb:4Q57|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0022400"(regulation of rhodopsin mediated signaling pathway)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031432"(titin binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0031997"(N-terminal myristoylation domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055117"(regulation of cardiac muscle contraction)|rcsb pdb:2MG5|go:"GO:0005088"|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0008440"(inositol-1,4,5-trisphosphate 3-kinase activity)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0005634"(nucleus)|rcsb pdb:4JPZ|ensembl:ENST00000272298|ensembl:ENST00000291295|ensembl:ENST00000356978|ensembl:ENST00000596362|refseq:NP_001292553.1|refseq:NP_001292554.1|rcsb pdb:4BYF|reactome:R-HSA-111932|reactome:R-HSA-111933|reactome:R-HSA-111957|reactome:R-HSA-111997|reactome:R-HSA-114608|reactome:R-HSA-1445148|reactome:R-HSA-1474151|reactome:R-HSA-180024|reactome:R-HSA-1855204|reactome:R-HSA-203615|reactome:R-HSA-2514859|reactome:R-HSA-2871809|reactome:R-HSA-4086398|reactome:R-HSA-442717|reactome:R-HSA-442729|reactome:R-HSA-442745|reactome:R-HSA-442982|reactome:R-HSA-445355|reactome:R-HSA-451308|reactome:R-HSA-5218920|reactome:R-HSA-5218921|reactome:R-HSA-5607763|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5673001|reactome:R-HSA-70221|reactome:R-HSA-983695|ensembl:ENSG00000143933|ensembl:ENSG00000160014|ensembl:ENSG00000198668|ensembl:ENSP00000272298|ensembl:ENSP00000291295|ensembl:ENSP00000349467|ensembl:ENSP00000472141|rcsb pdb:5NIN|rcsb pdb:5VMS|rcsb pdb:5WSU|rcsb pdb:5WSV|rcsb pdb:6U39|rcsb pdb:6U3A|rcsb pdb:6U3B|rcsb pdb:6U3D|rcsb pdb:2N8J|rcsb pdb:5GGM|rcsb pdb:5J8H|reactome:R-HSA-163615|reactome:R-HSA-5210891|refseq:NP_001316851.1|refseq:NP_001316852.1|refseq:NP_001316853.1|refseq:NP_001316854.1|refseq:NP_001316855.1|rcsb pdb:2N27|rcsb pdb:5DOW|rcsb pdb:5I0I|rcsb pdb:5J03|rcsb pdb:5K7L|rcsb pdb:5K8Q|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0043388"(positive regulation of DNA binding)|dip:DIP-31794N|rcsb pdb:1UP5|rcsb pdb:5JQA|rcsb pdb:5JTH|rcsb pdb:5OEO|rcsb pdb:5TP5|rcsb pdb:5TP6|rcsb pdb:5V02|rcsb pdb:5V03|rcsb pdb:5V7X|rcsb pdb:5WBX|rcsb pdb:5WC5|rcsb pdb:6B8L|rcsb pdb:6B8M|rcsb pdb:6B8N|rcsb pdb:6B8P|rcsb pdb:6B8Q|rcsb pdb:6C1D|rcsb pdb:6C1G|rcsb pdb:6C1H|rcsb pdb:6CNM|rcsb pdb:6CNN|rcsb pdb:6CNO|rcsb pdb:6FEG|rcsb pdb:6FEH|reactome:R-HSA-2025928|reactome:R-HSA-2151201|go:"GO:0034704"(calcium channel complex)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0051186"(obsolete cofactor metabolic process)|go:"GO:0075206"(obsolete positive regulation by host of symbiont cAMP-mediated signal transduction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|interpro:IPR039030|go:"GO:1902494"(catalytic complex)|go:"GO:0043234"|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0030819"(obsolete positive regulation of cAMP biosynthetic process)|rcsb pdb:6BUT|rcsb pdb:6DAD|rcsb pdb:6DAE|rcsb pdb:6DAF|rcsb pdb:6DAH|rcsb pdb:6E2F|rcsb pdb:6E2G|rcsb pdb:6EEB|rcsb pdb:6GDK|rcsb pdb:6GDL|rcsb pdb:6HCS|rcsb pdb:6JI8|rcsb pdb:6JII|rcsb pdb:6JIU|rcsb pdb:6JIY|rcsb pdb:6JRS|rcsb pdb:6JV2|rcsb pdb:6K4K|rcsb pdb:6K4L|rcsb pdb:6K4R|rcsb pdb:6MUD|rcsb pdb:6MUE|rcsb pdb:6N5W|rcsb pdb:6O5G|reactome:R-HSA-438066|reactome:R-HSA-442720|reactome:R-HSA-5673000|reactome:R-HSA-6802946|reactome:R-HSA-6802949|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9009391|reactome:R-HSA-9022535|reactome:R-HSA-9022692|reactome:R-HSA-9617324|reactome:R-HSA-9619229|reactome:R-HSA-9619483|reactome:R-HSA-9620244|go:"GO:0019722"(calcium-mediated signaling)|rcsb pdb:6PBX|rcsb pdb:6PBY|reactome:R-HSA-9649948|go:"GO:0005623"(obsolete cell)|rcsb pdb:6HR1|rcsb pdb:6OS4|rcsb pdb:6Y4P|rcsb pdb:6Y94|rcsb pdb:6Y95|reactome:R-HSA-9664323|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0016032"(viral process)|rcsb pdb:6M7H|rcsb pdb:6UZZ|rcsb pdb:6V00|rcsb pdb:6V01|rcsb pdb:6PLM|rcsb pdb:6S5T|rcsb pdb:6SZ5|rcsb pdb:6XXF|rcsb pdb:6Y4O	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:tTYcOd9bOh211njZVz7cYVybAMQ9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q13938	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-21820563|uniprotkb:A0A0X1KG78|uniprotkb:K7EL21|uniprotkb:Q3MJA7|uniprotkb:Q8NF12|uniprotkb:Q8WUZ3	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:cayp1_human(display_long)|uniprotkb:Calcyphosine(gene name synonym)|uniprotkb:CAPS(gene name)|psi-mi:CAPS(display_short)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_004049.2|refseq:NP_542157.2|rcsb pdb:3E3R|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0031982"(vesicle)|go:"GO:0035556"(intracellular signal transduction)	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:3mAKGNlKTe20V3NZHXBMLk1A9HY9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:O15169	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-710484|uniprotkb:Q4TT26|uniprotkb:Q4TT27|ensembl:ENSP00000262320|uniprotkb:Q86YA7|uniprotkb:Q8WVW6|uniprotkb:Q96S28	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:axin1_human(display_long)|uniprotkb:Axis inhibition protein 1(gene name synonym)|uniprotkb:AXIN1(gene name)|psi-mi:AXIN1(display_short)|uniprotkb:AXIN(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_003493.1|refseq:NP_851393.1|ensembl:ENSG00000103126(gene)|ensembl:ENST00000262320(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034622"|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046332"(SMAD binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0071944"(cell periphery)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR029797|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|mint:O15169|rcsb pdb:1DK8|rcsb pdb:1EMU|rcsb pdb:1O9U|rcsb pdb:3ZDI|rcsb pdb:4B7T|rcsb pdb:4NM0|rcsb pdb:4NM3|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:4NU1|rcsb pdb:5WZZ|rcsb pdb:6JCK|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-201681|reactome:R-HSA-4641257|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689880|reactome:R-HSA-8931987|reactome:R-HSA-8939256|reactome:R-HSA-9018519|dip:DIP-34630N	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:uO+LxY/7ibIZqdd5onbfXqGAZeo9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q9BZZ5	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-1048422|uniprotkb:O15441|uniprotkb:Q9Y4J7|uniprotkb:D3DR21|uniprotkb:B4DRJ2|uniprotkb:B4E283|uniprotkb:B4DGR0|ensembl:ENSP00000431391	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:api5_human(display_long)|uniprotkb:Fibroblast growth factor 2-interacting factor(gene name synonym)|uniprotkb:Protein XAGL(gene name synonym)|uniprotkb:Antiapoptosis clone 11 protein(gene name synonym)|uniprotkb:Cell migration-inducing gene 8 protein(gene name synonym)|uniprotkb:API5(gene name)|psi-mi:API5(display_short)|uniprotkb:MIG8(orf name)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001136402.1|refseq:NP_001136403.1|refseq:NP_006586.1|refseq:NP_001230676.1|ensembl:ENSG00000166181(gene)|ensembl:ENST00000531273(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|interpro:IPR008383(Apoptosis inhibitory 5)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|mint:Q9BZZ5|rcsb pdb:3U0R|rcsb pdb:3V6A|rcsb pdb:6L4O	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:WYNbM5GNolgFNszccnMEanszDgU9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P20073	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-2338704|uniprotkb:Q5F2H3|uniprotkb:Q5T0M6|uniprotkb:Q5T0M7|intact:EBI-28973842|ensembl:ENSP00000362010	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:anxa7_human(display_long)|uniprotkb:ANXA7(gene name)|psi-mi:ANXA7(display_short)|uniprotkb:ANX7(gene name synonym)|uniprotkb:SNX(gene name synonym)|uniprotkb:Annexin-7(gene name synonym)|uniprotkb:Annexin VII(gene name synonym)|uniprotkb:Synexin(gene name synonym)|uniprotkb:OK/SW-cl.95(orf name)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENSP00000362010|ensembl:ENST00000372921|ensembl:ENSP00000362012|refseq:NP_001147.1|refseq:NP_004025.1|refseq:XP_016871651.1|refseq:XP_016871652.1|ensembl:ENSG00000138279(gene)|ensembl:ENST00000372919(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006914"(autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0061025"(membrane fusion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001464(Annexin)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:ad3I49rhRoZ0hG8ruDgSQWocVuw9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P50995	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-715243|ensembl:ENSP00000361305|ensembl:ENSP00000398610|ensembl:ENSP00000404412|uniprotkb:B4DVE7|intact:EBI-10981770	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:anx11_human(display_long)|uniprotkb:Annexin-11(gene name synonym)|uniprotkb:Annexin XI(gene name synonym)|uniprotkb:Calcyclin-associated annexin 50(gene name synonym)|uniprotkb:56 kDa autoantigen(gene name synonym)|uniprotkb:ANXA11(gene name)|psi-mi:ANXA11(display_short)|uniprotkb:ANX11(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENSG00000122359(gene)|ensembl:ENST00000372231(transcript)|ensembl:ENST00000422982(transcript)|ensembl:ENST00000438331(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006909"(phagocytosis)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0016020"(membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030496"(midbody)|go:"GO:0032506"(cytokinetic process)|go:"GO:0042470"(melanosome)|go:"GO:0042581"(specific granule)|go:"GO:0042582"(azurophil granule)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001464(Annexin)|interpro:IPR008157(Annexin, type XI, N-terminal)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|refseq:NP_001148.1|refseq:NP_665875.1|refseq:NP_665876.1|refseq:XP_011538038.1|refseq:NP_001265336.1|refseq:NP_001265337.1|refseq:NP_001265338.1	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:6j7B4/J0DI0LZADQ5klJQoYf7289606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P62195	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-357745|uniprotkb:O35051|uniprotkb:O43208|uniprotkb:P52915|uniprotkb:P47210|uniprotkb:P52916|uniprotkb:A8K763|uniprotkb:A8K3Z3|ensembl:ENSP00000310572	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:prs8_human(display_long)|uniprotkb:PSMC5(gene name)|psi-mi:PSMC5(display_short)|uniprotkb:SUG1(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 5(gene name synonym)|uniprotkb:Proteasome subunit p45(gene name synonym)|uniprotkb:p45/SUG(gene name synonym)|uniprotkb:Thyroid hormone receptor-interacting protein 1(gene name synonym)|uniprotkb:26S proteasome AAA-ATPase subunit RPT6(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001186092.1|refseq:NP_002796.4|reactome:R-HSA-195253|ensembl:ENSG00000087191(gene)|ensembl:ENST00000310144(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031531"(thyrotropin-releasing hormone receptor binding)|go:"GO:0031595"(nuclear proteasome complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0090261"(positive regulation of inclusion body assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR032501|interpro:IPR041569|mint:P62195|rcsb pdb:2KRK|rcsb pdb:3KW6|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-36645N	-	-	crc64:29C6410C4A85A7F7	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:zgUTOX/O4m86U/Nf+pnT7u0m0gY9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P62191	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-357598|uniprotkb:P49014|uniprotkb:Q03527|uniprotkb:Q6IAW0|uniprotkb:Q96AZ3|ensembl:ENSP00000261303|uniprotkb:Q6NW36|uniprotkb:B4DR63	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:prs4_human(display_long)|uniprotkb:PSMC1(gene name)|psi-mi:PSMC1(display_short)|uniprotkb:26S proteasome AAA-ATPase subunit RPT2(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_002793.2|ensembl:ENST00000261303(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030163"(protein catabolic process)|ensembl:ENSG00000100764(gene)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:1901215"(negative regulation of neuron death)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR032501|interpro:IPR035244|interpro:IPR041569|mint:P62191|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFQ|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-532668|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-8852276|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|refseq:NP_001317141.1|refseq:XP_016876959.1	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:oGEtU7Cv0qversbD3WQgAo5H9pM9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q9UNM6	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-356070|uniprotkb:O75831|uniprotkb:Q9UNV3|uniprotkb:Q53XU2|intact:EBI-1058479|uniprotkb:B3KT15|ensembl:ENSP00000436186	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:psd13_human(display_long)|uniprotkb:PSMD13(gene name)|psi-mi:PSMD13(display_short)|uniprotkb:26S proteasome regulatory subunit S11(gene name synonym)|uniprotkb:26S proteasome regulatory subunit p40.5(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN9(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_002808.3|refseq:NP_787128.2|dip:DIP-27576N|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|rcsb pdb:6MSK|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|ensembl:ENSG00000185627(gene)|ensembl:ENST00000532097(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007127"(meiosis I)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043248"(proteasome assembly)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR035298|interpro:IPR036390|mint:Q9UNM6|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:iOxE62MMeGx+aqsrir/LukJqeho9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:O00232	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-359733|uniprotkb:Q53HA2|uniprotkb:Q6P053|ensembl:ENSP00000348442|uniprotkb:A6NP15	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:psd12_human(display_long)|uniprotkb:PSMD12(gene name)|psi-mi:PSMD12(display_short)|uniprotkb:26S proteasome regulatory subunit p55(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_002807.1|refseq:NP_001303270.1|ensembl:ENSG00000197170(gene)|ensembl:ENST00000356126(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031595"(nuclear proteasome complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR035297|interpro:IPR036388|interpro:IPR036390|interpro:IPR040134|interpro:IPR040896|mint:O00232|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|rcsb pdb:5VFS|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-5687128|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|refseq:NP_777360.1|dip:DIP-27549N	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:4tzcvfL/EqQRcUpoMtxVU0WC+TU9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P51149	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-1056089|uniprotkb:A8K3V6|uniprotkb:Q9NWJ0|uniprotkb:Q9UPB0|ensembl:ENSP00000265062|ensembl:ENSP00000501618|ensembl:ENSP00000502000|ensembl:ENSP00000502088|ensembl:ENSP00000502486	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:rab7a_human(display_long)|uniprotkb:RAB7A(gene name)|psi-mi:RAB7A(display_short)|uniprotkb:RAB7(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_004628.4|ensembl:ENSG00000075785(gene)|ensembl:ENST00000265062(transcript)|ensembl:ENST00000674589(transcript)|ensembl:ENST00000675342(transcript)|ensembl:ENST00000675497(transcript)|ensembl:ENST00000676214(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006897"(endocytosis)|go:"GO:0007174"(epidermal growth factor catabolic process)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0019003"(GDP binding)|go:"GO:0019076"(viral release from host cell)|go:"GO:0022615"(protein to membrane docking)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032419"(extrinsic component of lysosome membrane)|go:"GO:0033162"(melanosome membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048524"(positive regulation of viral process)|go:"GO:0061724"(lipophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090382"(phagosome maturation)|go:"GO:0090383"(phagosome acidification)|go:"GO:0090385"(phagosome-lysosome fusion)|go:"GO:0099638"(endosome to plasma membrane protein transport)|go:"GO:1902586"(obsolete multi-organism intercellular transport)|go:"GO:1903542"(negative regulation of exosomal secretion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1905366"(negative regulation of intralumenal vesicle formation)|go:"GO:1905394"(retromer complex binding)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P51149|rcsb pdb:1T91|rcsb pdb:1YHN|rcsb pdb:6IYB|rcsb pdb:6WCW|reactome:R-HSA-2132295|reactome:R-HSA-6798695|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9035034|reactome:R-HSA-9636383|reactome:R-HSA-9636569|rcsb pdb:3LAW|dip:DIP-39879N	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:AJbKizzw4zCAn+roRF2Im1Tt4xE9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P51148	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-1054923|intact:EBI-2798296|uniprotkb:Q9P0Y5|uniprotkb:Q6FH55|uniprotkb:F8W1H5|ensembl:ENSP00000345689|ensembl:ENSP00000377440	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:rab5c_human(display_long)|uniprotkb:RABL(gene name synonym)|uniprotkb:RAB5C(gene name)|psi-mi:RAB5C(display_short)|uniprotkb:RAB5L(gene name synonym)|uniprotkb:L1880(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_004574.2|refseq:NP_958842.1|refseq:XP_011523392.1|refseq:XP_011523393.1|refseq:NP_001238968.1|ensembl:ENSG00000108774(gene)|ensembl:ENST00000346213(transcript)|ensembl:ENST00000393860(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0012505"(endomembrane system)|go:"GO:0019003"(GDP binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042470"(melanosome)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:4KYI|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-8854214|reactome:R-HSA-8856828|reactome:R-HSA-8873719|reactome:R-HSA-8876198	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:sz3lmmxPJk0/IzQ9dZF0PzfNhBY9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:O95373	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-286735|uniprotkb:A6NNM5|uniprotkb:Q1RMF7|uniprotkb:Q9H177|uniprotkb:Q9NTE3|uniprotkb:B2R786|intact:EBI-28976968|ensembl:ENSP00000369042	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:ipo7_human(display_long)|uniprotkb:Ran-binding protein 7(gene name synonym)|uniprotkb:IPO7(gene name)|psi-mi:IPO7(display_short)|uniprotkb:RANBP7(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENSP00000369042|refseq:NP_006382.1|dip:DIP-32574N|ensembl:ENSG00000205339(gene)|ensembl:ENST00000379719(transcript)|go:"GO:0005215"(transporter activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042393"(histone binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046332"(SMAD binding)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013713(Exportin, Cse1-like)|interpro:IPR016024(Armadillo-type fold)|mint:O95373	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:aaTn9E3/dTUETnNBYr38fk4ZtDo9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:O00410	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-356424|uniprotkb:O15257|intact:EBI-1105173|uniprotkb:B4DZA0|uniprotkb:Q5T578|uniprotkb:Q86XC7|ensembl:ENSP00000350219|ensembl:ENSP00000418393|ensembl:ENSP00000499125	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:ipo5_human(display_long)|uniprotkb:IPO5(gene name)|psi-mi:IPO5(display_short)|uniprotkb:KPNB3(gene name synonym)|uniprotkb:RANBP5(gene name synonym)|uniprotkb:Importin subunit beta-3(gene name synonym)|uniprotkb:Karyopherin beta-3(gene name synonym)|uniprotkb:Ran-binding protein 5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_002262.3|refseq:XP_011519389.1|refseq:XP_011519390.1|refseq:XP_011519391.1|refseq:XP_011519392.1|ensembl:ENSG00000065150(gene)|ensembl:ENST00000357602(transcript)|ensembl:ENST00000490680(transcript)|ensembl:ENST00000651721(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|refseq:XP_005254109.1|refseq:XP_005254110.1|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|interpro:IPR000357(HEAT)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR034085|interpro:IPR040122|interpro:IPR040928|interpro:IPR041389|interpro:IPR041653|mint:O00410|rcsb pdb:6XTE|rcsb pdb:6XU2|reactome:R-HSA-192905|refseq:XP_016876051.1|dip:DIP-41042N	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:jBYLvkqyYyWAu1TdCVyCMh9ZHKY9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q9H4A6	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-2465479|uniprotkb:Q9UIW5|ensembl:ENSP00000265070	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:golp3_human(display_long)|uniprotkb:GOLPH3(gene name)|psi-mi:GOLPH3(display_short)|uniprotkb:GPP34(gene name synonym)|uniprotkb:Coat protein GPP34(gene name synonym)|uniprotkb:Mitochondrial DNA absence factor(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_071413.1|ensembl:ENSG00000113384(gene)|ensembl:ENST00000265070(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007030"(Golgi organization)|go:"GO:0009101"(glycoprotein biosynthetic process)|go:"GO:0009306"(protein secretion)|go:"GO:0010467"(gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016477"(cell migration)|go:"GO:0019899"(enzyme binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045053"(protein retention in Golgi apparatus)|go:"GO:0048194"(Golgi vesicle budding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060352"(cell adhesion molecule production)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0072752"(cellular response to rapamycin)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:0090164"(asymmetric Golgi ribbon formation)|interpro:IPR008628(Golgi phosphoprotein 3)|interpro:IPR038261|mint:Q9H4A6|rcsb pdb:3KN1	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:tHHREhHksCP+Yf9FzycM9cI+wkc9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q00610	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-354967|intact:EBI-28974011|ensembl:ENSP00000269122|uniprotkb:Q6N0A0|uniprotkb:Q86TF2|uniprotkb:D3DU00	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:clh1_human(display_long)|uniprotkb:Clathrin heavy chain on chromosome 17(gene name synonym)|uniprotkb:CLTC(gene name)|psi-mi:CLTC(display_short)|uniprotkb:CLH17(gene name synonym)|uniprotkb:KIAA0034(gene name synonym)|uniprotkb:CLTCL2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENSG00000141367(gene)|ensembl:ENST00000269122(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0030118"(clathrin coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0031623"(receptor internalization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033572"(transferrin transport)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|refseq:NP_004850.1|ensembl:ENSP00000269122|ensembl:ENST00000393043|ensembl:ENSP00000376763|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015348(Clathrin, heavy chain, linker, core motif)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016025(Clathrin, heavy chain, linker and propeller)|interpro:IPR016341(Clathrin, heavy chain)|interpro:IPR022365|mint:Q00610|rcsb pdb:2XZG|rcsb pdb:4G55|rcsb pdb:6E4L|rcsb pdb:6QNN|rcsb pdb:6QNP|reactome:R-HSA-168275|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-3928665|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9013420|reactome:R-HSA-9013424	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:oGsLXL5J5MHO+ronpDIG9hJ11sU9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q8N0Y2	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-6660528|ensembl:ENSP00000338860|uniprotkb:Q9NUU1|uniprotkb:Q8WU35|uniprotkb:Q8TEQ9	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:zn444_human(display_long)|uniprotkb:ZNF444(gene name)|psi-mi:ZNF444(display_short)|uniprotkb:EZF2(gene name synonym)|uniprotkb:Endothelial zinc finger protein 2(gene name synonym)|uniprotkb:ZSCAN17(gene name synonym)|uniprotkb:Zinc finger and SCAN domain-containing protein 17(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENSG00000167685(gene)|ensembl:ENST00000337080(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR003309(Transcriptional regulator SCAN)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR038269|refseq:XP_011525370.1|refseq:NP_001240721.1|refseq:NP_060807.2|refseq:XP_005259091.1|refseq:XP_005259092.1|refseq:XP_005259093.1	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:mtsW9JRIoWkvBjEsovYO7sKkcos9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:O75643	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-1045395|uniprotkb:O94884|uniprotkb:Q6PX59|uniprotkb:Q8NBE6|uniprotkb:Q96IF2|uniprotkb:Q9H7S0|uniprotkb:Q6NZY0|intact:EBI-1051631|ensembl:ENSP00000317123	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:u520_human(display_long)|uniprotkb:SNRNP200(gene name)|psi-mi:SNRNP200(display_short)|uniprotkb:HELIC2(gene name synonym)|uniprotkb:KIAA0788(gene name synonym)|uniprotkb:U5 snRNP-specific 200 kDa protein(gene name synonym)|uniprotkb:Activating signal cointegrator 1 complex subunit 3-like 1(gene name synonym)|uniprotkb:BRR2 homolog(gene name synonym)|uniprotkb:ASCC3L1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_054733.2|ensembl:ENSG00000144028(gene)|ensembl:ENST00000323853(transcript)|go:"GO:0000354"(cis assembly of pre-catalytic spliceosome)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|mint:O75643|rcsb pdb:2Q0Z|rcsb pdb:3JCR|rcsb pdb:4F91|rcsb pdb:4F92|rcsb pdb:4F93|rcsb pdb:4KIT|rcsb pdb:5O9Z|rcsb pdb:5URJ|rcsb pdb:5URK|rcsb pdb:5URM|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6S8O|rcsb pdb:6S8Q|rcsb pdb:6S9I|rcsb pdb:7A5P|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7BDI|rcsb pdb:7BDJ|rcsb pdb:7BDK|rcsb pdb:7BDL|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:XP_016859092.1|dip:DIP-31659N	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:2ZAcbMfMlk2xWWAiy7MeCL0CHtM9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q53GS9	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-1044822|uniprotkb:Q6NX47|uniprotkb:Q96RK9|uniprotkb:Q9BV89|uniprotkb:Q9H381|uniprotkb:Q9P050|uniprotkb:Q9Y310|uniprotkb:A8K086|ensembl:ENSP00000312981|ensembl:ENSP00000386864|uniprotkb:D6W5L4|intact:EBI-2557627|uniprotkb:B4DHT4|uniprotkb:B3KM40|uniprotkb:G5E9H0	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:snut2_human(display_long)|uniprotkb:U4/U6.U5 tri-snRNP-associated 65 kDa protein(gene name synonym)|uniprotkb:Inactive ubiquitin-specific peptidase 39(gene name synonym)|uniprotkb:SAD1 homolog(gene name synonym)|uniprotkb:USP39(gene name)|psi-mi:USP39(display_short)|uniprotkb:CGI-21(orf name)|uniprotkb:HSPC332(orf name)|uniprotkb:PRO2855(orf name)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_006581.2|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0051301"(cell division)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR028889|interpro:IPR033809|interpro:IPR038765|go:"GO:0007049"(cell cycle)|rcsb pdb:3JCR|rcsb pdb:6AH0|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|ensembl:ENSG00000168883(gene)|ensembl:ENST00000323701(transcript)|ensembl:ENST00000409470(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006397"(mRNA processing)|refseq:NP_001243656.1|refseq:NP_001243657.1|refseq:NP_001243654.1|refseq:NP_001243655.1|refseq:XP_006711985.1|refseq:XP_006711986.1|refseq:XP_011530789.1|refseq:XP_011530790.1|refseq:XP_016858671.1	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:AMLhskNenuv+zqXSa7VesSbbVK89606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q6P1X5	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-1560063|uniprotkb:O43487|uniprotkb:O43604|uniprotkb:O60668|uniprotkb:Q86WW7|uniprotkb:Q8IWK4|uniprotkb:B2RE82|ensembl:ENSP00000367406	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:taf2_human(display_long)|uniprotkb:Transcription initiation factor TFIID 150 kDa subunit(gene name synonym)|uniprotkb:TBP-associated factor 150 kDa(gene name synonym)|uniprotkb:150 kDa cofactor of initiator function(gene name synonym)|uniprotkb:RNA polymerase II TBP-associated factor subunit B(gene name synonym)|uniprotkb:TAF2(gene name)|psi-mi:TAF2(display_short)|uniprotkb:CIF150(gene name synonym)|uniprotkb:TAF2B(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_003175.1|dip:DIP-38921N|ensembl:ENSG00000064313(gene)|ensembl:ENST00000378164(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0033276"(transcription factor TFTC complex)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027268|interpro:IPR037813|interpro:IPR042097|mint:Q6P1X5|rcsb pdb:5FUR|rcsb pdb:6MZC|rcsb pdb:6MZL|rcsb pdb:6MZM|rcsb pdb:7EDX|rcsb pdb:7EG7|rcsb pdb:7EG8|rcsb pdb:7EG9|rcsb pdb:7EGA|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7EGD|rcsb pdb:7EGE|rcsb pdb:7EGH|rcsb pdb:7EGI|rcsb pdb:7EGJ|rcsb pdb:7ENA|rcsb pdb:7ENC|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-674695|reactome:R-HSA-6804756|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-76042	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:3MPkpqVRwuY2SiUxjQkcRFlq1RM9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P52655	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-389518|uniprotkb:Q3KNQ9|ensembl:ENSP00000452454	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:tf2aa_human(display_long)|uniprotkb:GTF2A1(gene name)|psi-mi:GTF2A1(display_short)|uniprotkb:TF2A1(gene name synonym)|uniprotkb:General transcription factor IIA subunit 1(gene name synonym)|uniprotkb:Transcription initiation factor TFIIA 42 kDa subunit(gene name synonym)|uniprotkb:TFIIAL(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_056943.1|refseq:NP_963889.1|refseq:NP_001265869.1|ensembl:ENSG00000165417(gene)|ensembl:ENST00000553612(transcript)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005672"(transcription factor TFIIA complex)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0097550"(transcription preinitiation complex)|interpro:IPR004855(Transcription factor IIA, alpha/beta subunit)|interpro:IPR009088(Transcription factor IIA, beta-barrel)|rcsb pdb:1NVP|rcsb pdb:5FUR|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:5M4S|rcsb pdb:6MZM|rcsb pdb:6O9L|rcsb pdb:7EDX|rcsb pdb:7EG7|rcsb pdb:7EG8|rcsb pdb:7EG9|rcsb pdb:7EGA|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7EGD|rcsb pdb:7EGI|rcsb pdb:7EGJ|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVS|rcsb pdb:7NVT|rcsb pdb:7NVU|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-674695|reactome:R-HSA-6807505|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-76042|reactome:R-HSA-9018519|dip:DIP-33225N	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:yatX/WS3e+54rhzDnTzIiI17JSY9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q13144	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-4401110|uniprotkb:Q541Z1|uniprotkb:Q96D04|ensembl:ENSP00000497160	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:ei2be_human(display_long)|uniprotkb:EIF2B5(gene name)|psi-mi:EIF2B5(display_short)|uniprotkb:EIF2BE(gene name synonym)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit epsilon(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_003898.2|ensembl:ENSG00000145191(gene)|ensembl:ENST00000648915(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0006413"(translational initiation)|go:"GO:0007568"(aging)|go:"GO:0009408"(response to heat)|go:"GO:0009749"(response to glucose)|go:"GO:0010226"(response to lithium ion)|go:"GO:0014002"(astrocyte development)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0021766"(hippocampus development)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042552"(myelination)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR001451(Bacterial transferase hexapeptide repeat)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR011004(Trimeric LpxA-like)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029044|interpro:IPR035543|interpro:IPR044123|rcsb pdb:3JUI|rcsb pdb:6CAJ|rcsb pdb:6EZO|rcsb pdb:6K71|rcsb pdb:6K72|rcsb pdb:6O81|rcsb pdb:6O85|rcsb pdb:6O9Z|rcsb pdb:7D43|rcsb pdb:7D44|rcsb pdb:7D45|rcsb pdb:7D46|rcsb pdb:7L70|rcsb pdb:7L7G|reactome:R-HSA-72731|go:"GO:0005634"(nucleus)	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:158kR+Yjj/jXya10LiK3Xp0Fa5w9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q9BSH4	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-747797|uniprotkb:Q8N3N6|uniprotkb:Q9UI60|uniprotkb:B2RD21|ensembl:ENSP00000258975	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:taco1_human(display_long)|uniprotkb:PRO0477(orf name)|uniprotkb:TACO1(gene name)|psi-mi:TACO1(display_short)|uniprotkb:CCDC44(gene name synonym)|uniprotkb:Translational activator of mitochondrially-encoded cytochrome c oxidase I(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 44(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_057444.2|ensembl:ENSG00000136463(gene)|ensembl:ENST00000258975(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0019843"(rRNA binding)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0061743"(motor learning)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:0097177"(mitochondrial ribosome binding)|go:"GO:1904959"(regulation of cytochrome-c oxidase activity)|interpro:IPR002876(Protein of unknown function DUF28)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR026564|interpro:IPR029072|mint:Q9BSH4|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:c/tu89NvCs3Kt8qO8e5F6hrywBo9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q15427	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-348469|ensembl:ENSP00000271628|intact:EBI-1047735|uniprotkb:Q5SZ63	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:sf3b4_human(display_long)|uniprotkb:SF3B4(gene name)|psi-mi:SF3B4(display_short)|uniprotkb:SAP49(gene name synonym)|uniprotkb:Spliceosome-associated protein 49(gene name synonym)|uniprotkb:Pre-mRNA-splicing factor SF3b 49 kDa subunit(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_005841.1|ensembl:ENSG00000143368(gene)|ensembl:ENST00000271628(transcript)|rcsb pdb:6QX9|rcsb pdb:6Y53|rcsb pdb:6Y5Q|rcsb pdb:7ABG|rcsb pdb:7ABH|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|rcsb pdb:6AHD|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:1990935"(splicing factor binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034158|go:"GO:0000375"(RNA splicing, via transesterification reactions)|interpro:IPR034159|interpro:IPR035979|mint:Q15427|rcsb pdb:1X5T|rcsb pdb:5GVQ|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:Jgy6WmBFKkphpZLLte2GgsagUVI9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q15393	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-346977|uniprotkb:Q6NTI8|uniprotkb:Q96GC0|uniprotkb:Q9BPY2|uniprotkb:Q9UFX7|uniprotkb:Q9UJ29|ensembl:ENSP00000305790	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:sf3b3_human(display_long)|uniprotkb:SF3B3(gene name)|psi-mi:SF3B3(display_short)|uniprotkb:KIAA0017(gene name synonym)|uniprotkb:SAP130(gene name synonym)|uniprotkb:Spliceosome-associated protein 130(gene name synonym)|uniprotkb:Pre-mRNA-splicing factor SF3b 130 kDa subunit(gene name synonym)|uniprotkb:STAF130(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_036558.3|dip:DIP-28152N|ensembl:ENSG00000189091(gene)|ensembl:ENST00000302516(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|rcsb pdb:5O9Z|go:"GO:0005654"(nucleoplasm)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|go:"GO:0005730"(nucleolus)|go:"GO:0008380"(RNA splicing)|rcsb pdb:5ZYA|rcsb pdb:6AH0|go:"GO:0030620"(U2 snRNA binding)|rcsb pdb:6AHD|rcsb pdb:6EN4|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6QX9|rcsb pdb:6Y50|rcsb pdb:6Y5Q|rcsb pdb:7ABG|rcsb pdb:7ABH|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR004871(Cleavage and polyadenylation specificity factor, A subunit, C-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018846|interpro:IPR036322|mint:Q15393|rcsb pdb:5IFE	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:gnCSXjZ/bwNXair6kyQUKoKIwbM9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q13838	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-348622|uniprotkb:B0S8C0|uniprotkb:Q5STB8|uniprotkb:O43496|uniprotkb:Q0EFA1|uniprotkb:Q2L6F9|uniprotkb:Q53GL9|uniprotkb:Q5RJ64|uniprotkb:Q5RJ66|uniprotkb:Q5ST94|uniprotkb:Q5STB4|uniprotkb:Q5STB5|uniprotkb:Q5STB7|uniprotkb:Q5STU4|uniprotkb:Q5STU5|uniprotkb:Q5STU6|uniprotkb:Q5STU8|uniprotkb:Q71V76|ensembl:ENSP00000373000|ensembl:ENSP00000379475|ensembl:ENSP00000383151|ensembl:ENSP00000383152|ensembl:ENSP00000387994|ensembl:ENSP00000388880|ensembl:ENSP00000390999|ensembl:ENSP00000391463|ensembl:ENSP00000393712|ensembl:ENSP00000394160|ensembl:ENSP00000398775|ensembl:ENSP00000399030|ensembl:ENSP00000400326|ensembl:ENSP00000404695|ensembl:ENSP00000405560|ensembl:ENSP00000407419|ensembl:ENSP00000411136|ensembl:ENSP00000411853|ensembl:ENSP00000416269	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:dx39b_human(display_long)|uniprotkb:UAP56(gene name synonym)|uniprotkb:DDX39B(gene name)|psi-mi:DDX39B(display_short)|uniprotkb:DEAD box protein UAP56(gene name synonym)|uniprotkb:56 kDa U2AF65-associated protein(gene name synonym)|uniprotkb:ATP-dependent RNA helicase p47(gene name synonym)|uniprotkb:HLA-B-associated transcript 1 protein(gene name synonym)|uniprotkb:BAT1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_004631.1|refseq:NP_542165.1|ensembl:ENSG00000198563(gene)|ensembl:ENSG00000215425(gene)|ensembl:ENSG00000225073(gene)|ensembl:ENSG00000225859(gene)|ensembl:ENSG00000229496(gene)|ensembl:ENSG00000230624(gene)|ensembl:ENSG00000235439(gene)|ensembl:ENST00000383508(transcript)|ensembl:ENST00000396172(transcript)|ensembl:ENST00000400295(transcript)|ensembl:ENST00000400296(transcript)|ensembl:ENST00000412106(transcript)|ensembl:ENST00000412330(transcript)|ensembl:ENST00000413678(transcript)|ensembl:ENST00000414440(transcript)|ensembl:ENST00000415689(transcript)|ensembl:ENST00000416863(transcript)|ensembl:ENST00000430784(transcript)|ensembl:ENST00000431360(transcript)|ensembl:ENST00000441425(transcript)|ensembl:ENST00000445218(transcript)|ensembl:ENST00000448296(transcript)|ensembl:ENST00000453138(transcript)|ensembl:ENST00000456476(transcript)|ensembl:ENST00000456666(transcript)|ensembl:ENST00000458640(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000346"(transcription export complex)|go:"GO:0001889"(liver development)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005688"(U6 snRNP)|go:"GO:0005737"(cytoplasm)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0008186"(ATP-dependent activity, acting on RNA)|go:"GO:0008380"(RNA splicing)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046784"(viral mRNA export from host cell nucleus)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q13838|rcsb pdb:1T5I|rcsb pdb:1T6N|rcsb pdb:1XTI|rcsb pdb:1XTJ|rcsb pdb:1XTK|rcsb pdb:7APK|reactome:R-HSA-159236|reactome:R-HSA-72187|reactome:R-HSA-73856|reactome:R-HSA-9013418	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:Cl/rf1oq31fZbLHC2foUXu9MBOE9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q13523	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-395940|uniprotkb:Q8TDP2|uniprotkb:Q96QT7|uniprotkb:Q9UEE6|uniprotkb:Q5TAY8|uniprotkb:A8K5C9|uniprotkb:Q5D0F6|uniprotkb:Q8IVC3|intact:EBI-1058380|ensembl:ENSP00000337194|ensembl:ENSP00000433547	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:prp4b_human(display_long)|uniprotkb:PRPF4B(gene name)|psi-mi:PRPF4B(display_short)|uniprotkb:KIAA0536(gene name synonym)|uniprotkb:PRP4(gene name synonym)|uniprotkb:PRP4H(gene name synonym)|uniprotkb:PRP4K(gene name synonym)|uniprotkb:PRP4 pre-mRNA-processing factor 4 homolog(gene name synonym)|uniprotkb:PRP4 kinase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_003904.3|ensembl:ENSG00000112739(gene)|ensembl:ENST00000337659(transcript)|ensembl:ENST00000480058(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR044092|mint:Q13523|rcsb pdb:4IAN|rcsb pdb:4IFC|rcsb pdb:4IIR|rcsb pdb:4IJP|rcsb pdb:6CNH|rcsb pdb:6PJJ|rcsb pdb:6PK6|rcsb pdb:6QX9|refseq:XP_016866899.1|refseq:XP_016866900.1|refseq:XP_016866901.1|refseq:XP_016866902.1|refseq:XP_016866903.1|refseq:XP_016866904.1|refseq:XP_016866905.1|refseq:XP_016866906.1|refseq:XP_016866907.1|refseq:XP_016866908.1|refseq:XP_016866909.1|refseq:XP_016866910.1|refseq:XP_016866911.1|refseq:XP_016866912.1|refseq:XP_016866913.1|refseq:XP_016866914.1|refseq:XP_016866915.1|refseq:XP_016866916.1|refseq:XP_016866917.1|refseq:XP_016866918.1|refseq:XP_016866919.1|refseq:XP_016866920.1	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:ZklPbRvRbbVRJYqV3JkS2jG3EIc9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q96QC0	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-1210346|uniprotkb:O00405|ensembl:ENSP00000365694|ensembl:ENSP00000373080|ensembl:ENSP00000389299|ensembl:ENSP00000407181|ensembl:ENSP00000407310|ensembl:ENSP00000413554|ensembl:ENSP00000416060	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:pp1ra_human(display_long)|uniprotkb:PPP1R10(gene name)|psi-mi:PPP1R10(display_short)|uniprotkb:CAT53(gene name synonym)|uniprotkb:FB19(gene name synonym)|uniprotkb:PNUTS(gene name synonym)|uniprotkb:Phosphatase 1 nuclear targeting subunit(gene name synonym)|uniprotkb:MHC class I region proline-rich protein CAT53(gene name synonym)|uniprotkb:Protein FB19(gene name synonym)|uniprotkb:PP1-binding protein of 114 kDa(gene name synonym)|uniprotkb:p99(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:XP_011513024.1|refseq:NP_002705.2|refseq:XP_006715193.1|refseq:XP_016866484.1|dip:DIP-39343N|ensembl:ENSG00000204569(gene)|ensembl:ENSG00000206489(gene)|ensembl:ENSG00000227804(gene)|ensembl:ENSG00000230995(gene)|ensembl:ENSG00000231737(gene)|ensembl:ENSG00000235291(gene)|ensembl:ENSG00000238104(gene)|ensembl:ENST00000376511(transcript)|ensembl:ENST00000383586(transcript)|ensembl:ENST00000420949(transcript)|ensembl:ENST00000424446(transcript)|ensembl:ENST00000426299(transcript)|ensembl:ENST00000429597(transcript)|ensembl:ENST00000449113(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0016604"(nuclear body)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0046872"(metal ion binding)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:1904290"(negative regulation of mitotic DNA damage checkpoint)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR003617(Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type)|interpro:IPR017923|interpro:IPR035441|interpro:IPR036855|mint:Q96QC0|go:"GO:0000785"(chromatin)	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:ZWueXxqNFYPT0WhbfYdR3d2H2G89606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q8IZQ5	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-2477343|intact:EBI-28975233|ensembl:ENSP00000373509|ensembl:ENSP00000434511|uniprotkb:Q8N672	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:selh_human(display_long)|uniprotkb:SELENOH(gene name)|psi-mi:SELENOH(display_short)|uniprotkb:C11orf31(gene name synonym)|uniprotkb:SELH(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENSG00000211450(gene)|ensembl:ENST00000388857(transcript)|ensembl:ENST00000534355(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005794"(Golgi apparatus)|interpro:IPR011893(SelT/selW/selH selenoprotein)|interpro:IPR036249|ensembl:ENSP00000373509|ensembl:ENSP00000434511|refseq:NP_734467.1|refseq:NP_001308264.1	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:Ew+PKOj0fqVfxYQhF9w6Ni8TmFA9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q9UI43	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-16769706|ensembl:ENSP00000242257|ensembl:ENSP00000392343|uniprotkb:Q24JR8	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:mrm2_human(display_long)|uniprotkb:MRM2(gene name)|psi-mi:MRM2(display_short)|uniprotkb:FJH1(gene name synonym)|uniprotkb:FTSJ2(gene name synonym)|uniprotkb:"16S rRNA (uridine(1369)-2'-O)-methyltransferase"(gene name synonym)|uniprotkb:16S rRNA [Um1369] 2'-O-methyltransferase(gene name synonym)|uniprotkb:Protein ftsJ homolog 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENSG00000122687(gene)|ensembl:ENST00000242257(transcript)|ensembl:ENST00000440306(transcript)|go:"GO:0000451"(rRNA 2'-O-methylation)|go:"GO:0001510"(RNA methylation)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006364"(rRNA processing)|go:"GO:0008173"(RNA methyltransferase activity)|go:"GO:0008650"("rRNA (uridine-2'-O-)-methyltransferase activity")|go:"GO:0031167"(rRNA methylation)|interpro:IPR002877(Ribosomal RNA methyltransferase RrmJ/FtsJ)|interpro:IPR015507(Ribosomal RNA methyltransferase J)|interpro:IPR029063|rcsb pdb:2NYU|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODS|reactome:R-HSA-6793080|refseq:NP_037525.1	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:HZYsSyMhYH4woIjb1efeB8syDBw9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P22087	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-358318|uniprotkb:O75259|uniprotkb:Q6IAT5|uniprotkb:Q9UPI6|ensembl:ENSP00000221801|ensembl:ENSP00000487390|uniprotkb:B5BUE8	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:fbrl_human(display_long)|uniprotkb:FBL(gene name)|psi-mi:FBL(display_short)|uniprotkb:FIB1(gene name synonym)|uniprotkb:FLRN(gene name synonym)|uniprotkb:Histone-glutamine methyltransferase(gene name synonym)|uniprotkb:34 kDa nucleolar scleroderma antigen(gene name synonym)|uniprotkb:U6 snRNA 2'-O-methyltransferase fibrillarin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001427.2|ensembl:ENSG00000105202(gene)|ensembl:ENSG00000280548(gene)|ensembl:ENST00000221801(transcript)|ensembl:ENST00000625241(transcript)|go:"GO:0000494"(box C/D RNA 3'-end processing)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001650"(fibrillar center)|go:"GO:0001651"(dense fibrillar component)|go:"GO:0001652"(granular component)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0008649"(rRNA methyltransferase activity)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0031167"(rRNA methylation)|go:"GO:0031428"(box C/D RNP complex)|go:"GO:0032040"(small-subunit processome)|go:"GO:0048254"(snoRNA localization)|go:"GO:0051117"(ATPase binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990258"(histone glutamine methylation)|go:"GO:1990259"(histone-glutamine methyltransferase activity)|interpro:IPR000692(Fibrillarin)|interpro:IPR020813|interpro:IPR029063|mint:P22087|rcsb pdb:2IPX|reactome:R-HSA-6790901|reactome:R-HSA-6791226|dip:DIP-27569N	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:8m8FDRSxGNKNXpJMcWWbcHL3uss9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q9NW13	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-2878099|ensembl:ENSP00000223073|uniprotkb:Q96CV3|uniprotkb:A4D100|uniprotkb:Q53H65|uniprotkb:B4DU52|uniprotkb:E9PDD9	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:rbm28_human(display_long)|uniprotkb:RBM28(gene name)|psi-mi:RBM28(display_short)|uniprotkb:RNA-binding motif protein 28(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|mint:Q9NW13|reactome:R-HSA-6791226|go:"GO:0003723"(RNA binding)|ensembl:ENSG00000106344(gene)|ensembl:ENST00000223073(transcript)|refseq:NP_001159607.1|refseq:NP_060547.2	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:yIPQX+d5YQpq3gpdtBilOXJcUsg9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q9BRX2	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-1043580|uniprotkb:Q9GZS6|uniprotkb:Q9Y306|ensembl:ENSP00000274311	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:pelo_human(display_long)|uniprotkb:PELO(gene name)|psi-mi:PELO(display_short)|uniprotkb:CGI-17(orf name)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENSG00000152684(gene)|ensembl:ENST00000274311(transcript)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0007049"(cell cycle)|go:"GO:0007492"(endoderm development)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032790"(ribosome disassembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|go:"GO:0060231"(mesenchymal to epithelial transition)|go:"GO:0070481"(nuclear-transcribed mRNA catabolic process, non-stop decay)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0070966"(nuclear-transcribed mRNA catabolic process, no-go decay)|go:"GO:0071025"(RNA surveillance)|interpro:IPR004405(Probable translation factor pelota)|interpro:IPR005140(eRF1 domain 1)|interpro:IPR005141(eRF1 domain 2)|interpro:IPR005142(eRF1 domain 3)|interpro:IPR029064|interpro:IPR038069|interpro:IPR042226|mint:Q9BRX2|rcsb pdb:1X52|rcsb pdb:5EO3|rcsb pdb:5LZW|rcsb pdb:5LZX|rcsb pdb:5LZY|rcsb pdb:5LZZ|refseq:NP_057030.3	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:EZIi8JN2tu0u4oH06fOus3LKjoo9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:O43660	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-1051504|uniprotkb:Q3KQY5|uniprotkb:Q8WUD8|uniprotkb:B3KMK4|ensembl:ENSP00000424417	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:plrg1_human(display_long)|uniprotkb:PLRG1(gene name)|psi-mi:PLRG1(display_short)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001188493.1|refseq:NP_002660.1|ensembl:ENSG00000171566(gene)|ensembl:ENST00000499023(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000974"(Prp19 complex)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:O43660|rcsb pdb:4YVD|rcsb pdb:5MQF|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6ZYM|rcsb pdb:7AAV|rcsb pdb:7ABF|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7DH6|rcsb pdb:7DVQ|reactome:R-HSA-72163|interpro:IPR020472	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:TdZ60+R9eEw7Q0zgsHjv8DImHMA9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q9H361	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-1055272|uniprotkb:Q8NHV0|uniprotkb:Q9H086|ensembl:ENSP00000281589	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:pabp3_human(display_long)|uniprotkb:"Testis-specific poly(A)-binding protein"(gene name synonym)|uniprotkb:PABPC3(gene name)|psi-mi:PABPC3(display_short)|uniprotkb:PABP3(gene name synonym)|uniprotkb:PABPL3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_112241.2|ensembl:ENSG00000151846(gene)|ensembl:ENST00000281589(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016071"(mRNA metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR006515(Polyadenylate binding protein, human types 1, 2, 3, 4)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR036053|mint:Q9H361|rcsb pdb:2D9P|rcsb pdb:4IVE	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:g/tDJDBcBC+s8P6LGDIwgZO8HHY9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q8WUA2	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-2513119|ensembl:ENSP00000253329|uniprotkb:B2RD34|uniprotkb:Q7Z3Q5	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:ppil4_human(display_long)|uniprotkb:PPIL4(gene name)|psi-mi:PPIL4(display_short)|uniprotkb:Cyclophilin-like protein PPIL4(gene name synonym)|uniprotkb:Rotamase PPIL4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	go:"GO:1901407"(regulation of phosphorylation of RNA polymerase II C-terminal domain)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR029000|interpro:IPR035538|interpro:IPR035542|interpro:IPR035979|mint:Q8WUA2|reactome:R-HSA-72163|go:"GO:0005829"(cytosol)|ensembl:ENSG00000131013(gene)|ensembl:ENST00000253329(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|refseq:NP_624311.1	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:kxM/VRcLUG5M5FAlHuuAKRBKrd89606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q9H0G5	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-5464397|uniprotkb:Q6FI71|ensembl:ENSP00000247026	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:nsrp1_human(display_long)|uniprotkb:NSRP1(gene name)|psi-mi:NSRP1(display_short)|uniprotkb:CCDC55(gene name synonym)|uniprotkb:NSRP70(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 55(gene name synonym)|uniprotkb:Nuclear speckle-related protein 70(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_115517.1|refseq:NP_001248396.1|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0032502"(developmental process)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR018612|interpro:IPR042816|mint:Q9H0G5|go:"GO:0005654"(nucleoplasm)|ensembl:ENSG00000126653(gene)|ensembl:ENST00000247026(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:Hp8MjUsGzGZWl+Y/zyzkOxjnLc49606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P49790	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-286779|uniprotkb:Q5T9I7|intact:EBI-1237421|uniprotkb:E7EPX5|uniprotkb:Q4LE47|uniprotkb:Q7Z743|uniprotkb:B4DIK2|uniprotkb:F6QR24|ensembl:ENSP00000262077	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:nu153_human(display_long)|uniprotkb:Nucleoporin Nup153(gene name synonym)|uniprotkb:153 kDa nucleoporin(gene name synonym)|uniprotkb:NUP153(gene name)|psi-mi:NUP153(display_short)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENSP00000262077|ensembl:ENST00000537253|ensembl:ENSP00000444029|ensembl:ENST00000613258|ensembl:ENSP00000478627|refseq:NP_005115.2|refseq:NP_001265138.1|refseq:NP_001265139.1|dip:DIP-38185N|ensembl:ENSG00000124789(gene)|ensembl:ENST00000262077(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0016020"(membrane)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034399"(nuclear periphery)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042802"(identical protein binding)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0043657"(host cell)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046832"(negative regulation of RNA export from nucleus)|go:"GO:0046872"(metal ion binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR013913(Nucleoporin, Nup153-like)|interpro:IPR018892|interpro:IPR026054|interpro:IPR036443|mint:P49790|rcsb pdb:2EBQ|rcsb pdb:2EBR|rcsb pdb:2EBV|rcsb pdb:2GQE|rcsb pdb:4U0C|rcsb pdb:4U0D|rcsb pdb:5TSV|rcsb pdb:5TSX|rcsb pdb:6AYA|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:rOax/ikcAu5fmDiCOauVr7Y/fzY9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q9H7H0	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-749353|intact:EBI-948255|uniprotkb:Q9BSH1|uniprotkb:Q9BZH2|uniprotkb:Q9BZH3|ensembl:ENSP00000343041	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:met17_human(display_long)|uniprotkb:METT11D1(gene name synonym)|uniprotkb:Protein RSM22 homolog, mitochondrial(gene name synonym)|uniprotkb:METTL17(gene name)|psi-mi:METTL17(display_short)|uniprotkb:Methyltransferase 11 domain-containing protein 1(gene name synonym)|uniprotkb:False p73 target gene protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001025162.1|refseq:NP_073571.1|ensembl:ENSG00000165792(gene)|ensembl:ENST00000339374(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006412"(translation)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0032259"(methylation)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:1904047"(S-adenosyl-L-methionine binding)|interpro:IPR015324(Ribosomal protein Rsm22, bacterial-type)|interpro:IPR029063|mint:Q9H7H0	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:RAj8jOqwthd7a0Xzi5FWhVKc8OI9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P31942	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-711437|uniprotkb:Q9NPI4|uniprotkb:Q9UFU4|uniprotkb:Q9Y4J5|uniprotkb:Q9BSX1|uniprotkb:Q9NP53|uniprotkb:Q9NP96|uniprotkb:Q9NPA7|ensembl:ENSP00000265866|uniprotkb:A8K682|uniprotkb:B3KRE1	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:hnrh3_human(display_long)|uniprotkb:HNRNPH3(gene name)|psi-mi:HNRNPH3(display_short)|uniprotkb:HNRPH3(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein 2H9(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENSG00000096746(gene)|ensembl:ENST00000265866(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034969|interpro:IPR034970|interpro:IPR035979|mint:P31942|refseq:NP_036339.1|refseq:NP_067676.2|refseq:NP_001309363.1|refseq:NP_001309365.1|refseq:NP_001309366.1|refseq:NP_001309367.1|refseq:NP_001309368.1|refseq:NP_001309369.1|refseq:NP_001309370.1|refseq:NP_001309374.1|refseq:NP_001309375.1|refseq:NP_001309376.1|refseq:NP_001309377.1|refseq:NP_001309378.1|refseq:XP_016871657.1|refseq:XP_016871658.1	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:iJGBIhPXnQIIFQmgxWB1WjwVXSY9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P51991	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-1050760|uniprotkb:Q53RW7|uniprotkb:Q6URK5|uniprotkb:D3DPF4|ensembl:ENSP00000376309|ensembl:ENSP00000416340|ensembl:ENSP00000503593|ensembl:ENSP00000504135|ensembl:ENSP00000504152	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:roa3_human(display_long)|uniprotkb:HNRPA3(gene name synonym)|uniprotkb:HNRNPA3(gene name)|psi-mi:HNRNPA3(display_short)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_919223.1|refseq:NP_001317178.1|ensembl:ENSG00000170144(gene)|ensembl:ENST00000392524(transcript)|ensembl:ENST00000435711(transcript)|ensembl:ENST00000676629(transcript)|ensembl:ENST00000678111(transcript)|ensembl:ENST00000679159(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0014069"(postsynaptic density)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0043005"(neuron projection)|go:"GO:0051028"(mRNA transport)|go:"GO:0051033"(RNA transmembrane transporter activity)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034513|interpro:IPR034516|interpro:IPR035979|mint:P51991|reactome:R-HSA-72163|reactome:R-HSA-72203	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:bbg0nIdhEHomcwtgZhT2yHy7+nU9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q32P51	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-2556580|uniprotkb:Q5TBS2|ensembl:ENSP00000350090	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:ra1l2_human(display_long)|uniprotkb:HNRNPA1L(gene name synonym)|uniprotkb:HNRNPA1L2(gene name)|psi-mi:HNRNPA1L2(display_short)|uniprotkb:hnRNP core protein A1-like 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001011724.1|refseq:NP_001011725.1|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0051028"(mRNA transport)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR021662|interpro:IPR034803|interpro:IPR035979|mint:Q32P51|go:"GO:0005681"(spliceosomal complex)|ensembl:ENSG00000139675(gene)|ensembl:ENST00000357495(transcript)|go:"GO:0003723"(RNA binding)	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:Xx00SLimJrf+0e9CrvzUV9PJPcI9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q99729	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-1044873|uniprotkb:Q04150|uniprotkb:Q8N7U3|uniprotkb:Q9BQ99|intact:EBI-2339961|uniprotkb:B3KNN5|uniprotkb:D3DWP7	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:roaa_human(display_long)|uniprotkb:HNRPAB(gene name synonym)|uniprotkb:APOBEC1-binding protein 1(gene name synonym)|uniprotkb:HNRNPAB(gene name)|psi-mi:HNRNPAB(display_short)|uniprotkb:ABBP1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_004490.2|refseq:NP_112556.2|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012956(CBF, N-terminal)|interpro:IPR034846|interpro:IPR035979|rcsb pdb:3S7R|mint:Q99729|dip:DIP-50394N	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:NzusDKSvcoVb90LNvXpaMAvg0Oo9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:O75616	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-6393536|ensembl:ENSP00000254928|uniprotkb:B3KN21|uniprotkb:C9JEC6|uniprotkb:O75617|uniprotkb:Q8WUY4|uniprotkb:Q96LE2|uniprotkb:Q96TC0	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:eral1_human(display_long)|uniprotkb:ERAL1(gene name)|psi-mi:ERAL1(display_short)|uniprotkb:HERA(gene name synonym)|uniprotkb:Conserved ERA-like GTPase(gene name synonym)|uniprotkb:ERA-W(gene name synonym)|uniprotkb:ERA-like protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENSG00000132591(gene)|ensembl:ENST00000254928(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0019843"(rRNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0043024"(ribosomal small subunit binding)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR005662(GTP-binding protein Era)|interpro:IPR006073(GTP1/OBG)|interpro:IPR009019(K Homology, prokaryotic type)|interpro:IPR015946(K homology-like, alpha/beta)|interpro:IPR027417|interpro:IPR030388|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|refseq:NP_005693.1|refseq:NP_001304914.1|refseq:NP_001304915.1	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:2usCrRc4/GbXG5Ft8GY61w+rGds9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q9UKN8	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-1237240|uniprotkb:Q5VZJ7|ensembl:ENSP00000361219	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:tf3c4_human(display_long)|uniprotkb:GTF3C4(gene name)|psi-mi:GTF3C4(display_short)|uniprotkb:Transcription factor IIIC subunit delta(gene name synonym)|uniprotkb:TF3C-delta(gene name synonym)|uniprotkb:Transcription factor IIIC 90 kDa subunit(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_036336.2|ensembl:ENSG00000125484(gene)|ensembl:ENST00000372146(transcript)|go:"GO:0000127"(transcription factor TFIIIC complex)|go:"GO:0003677"(DNA binding)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0006384"(transcription initiation from RNA polymerase III promoter)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0042791"(5S class rRNA transcription by RNA polymerase III)|go:"GO:0042797"(tRNA transcription by RNA polymerase III)|interpro:IPR024761|interpro:IPR024764|interpro:IPR036322|interpro:IPR044230|mint:Q9UKN8|reactome:R-HSA-749476|reactome:R-HSA-76061|reactome:R-HSA-76066	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:OFldz80WMs7KQ59Of0rkkj80lyc9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P51114	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P56537	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-372243|uniprotkb:Q6IBN8|uniprotkb:Q96TD5|uniprotkb:B7ZBG9|ensembl:ENSP00000363559|ensembl:ENSP00000363574|ensembl:ENSP00000502429	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:if6_human(display_long)|uniprotkb:EIF6(gene name)|psi-mi:EIF6(display_short)|uniprotkb:ITGB4BP(gene name synonym)|uniprotkb:OK/SW-cl.27(orf name)|uniprotkb:B4 integrin interactor(gene name synonym)|uniprotkb:CAB(gene name synonym)|uniprotkb:"p27(BBP)"(gene name synonym)|uniprotkb:"B(2)GCN homolog"(gene name synonym)|uniprotkb:EIF3A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_002203.1|refseq:NP_852131.1|refseq:NP_852133.1|refseq:NP_001254739.1|ensembl:ENSG00000242372(gene)|ensembl:ENST00000374436(transcript)|ensembl:ENST00000374450(transcript)|ensembl:ENST00000675032(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005638"(lamin filament)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0032868"(response to insulin)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0042304"(regulation of fatty acid biosynthetic process)|go:"GO:0043022"(ribosome binding)|go:"GO:0043023"(ribosomal large subunit binding)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902626"(assembly of large subunit precursor of preribosome)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR002769(Translation initiation factor IF6)|mint:P56537|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:A0pOylQptNBlSiBKiZre7INejF49606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P78344	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-296519|uniprotkb:O60877|uniprotkb:P78404|uniprotkb:Q0VH00|uniprotkb:Q53EU1|uniprotkb:Q58EZ2|uniprotkb:Q8NI71|uniprotkb:Q96C16|ensembl:ENSP00000340281|ensembl:ENSP00000433371|ensembl:ENSP00000433664|uniprotkb:Q0VH01|uniprotkb:Q2NKW9|uniprotkb:Q49A79	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:if4g2_human(display_long)|uniprotkb:EIF4G2(gene name)|psi-mi:EIF4G2(display_short)|uniprotkb:DAP5(gene name synonym)|uniprotkb:OK/SW-cl.75(orf name)|uniprotkb:p97(gene name synonym)|uniprotkb:Death-associated protein 5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENSG00000110321(gene)|ensembl:ENST00000339995(transcript)|ensembl:ENST00000525681(transcript)|ensembl:ENST00000526148(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0007507"(heart development)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0008219"(cell death)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0034645"(cellular macromolecule biosynthetic process)|go:"GO:0045296"(cadherin binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060999"(positive regulation of dendritic spine development)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR003890(MIF4G-like, type 3)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|interpro:IPR003891(Initiation factor eIF-4 gamma, MA3)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|mint:P78344|rcsb pdb:3D3M|rcsb pdb:3L6A|rcsb pdb:4IUL|reactome:R-HSA-1169408|refseq:NP_001036024.3|refseq:NP_001166176.1|refseq:NP_001409.3|dip:DIP-31366N	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:UIE1Um0s2KJ9hpaa9X6kfZ8enPc9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q9Y262	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-373519|uniprotkb:Q53HQ1|uniprotkb:Q53HT4|uniprotkb:Q5QTR1|uniprotkb:Q5TI15|uniprotkb:Q6ICD2|uniprotkb:B2RDG6|uniprotkb:B4DYB2|uniprotkb:G8JLH4|intact:EBI-10970119|ensembl:ENSP00000485663|ensembl:ENSP00000499067	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:eif3l_human(display_long)|uniprotkb:EIF3L(gene name)|psi-mi:EIF3L(display_short)|uniprotkb:HSPC021(orf name)|uniprotkb:HSPC025(orf name)|uniprotkb:EIF3S6IP(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 6-interacting protein(gene name synonym)|uniprotkb:MSTP005(orf name)|uniprotkb:EIF3EIP(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit E-interacting protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_057175.1|refseq:NP_001229852.1|dip:DIP-31172N|ensembl:ENSG00000100129(gene)|ensembl:ENST00000624234(transcript)|ensembl:ENST00000652021(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019382|mint:Q9Y262|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6FEC|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:C9ES0WpTdEHUkjWeZK/SoDP/dAo9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P60228	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-347740|uniprotkb:O43902|uniprotkb:Q64058|uniprotkb:Q64059|uniprotkb:Q64252|uniprotkb:Q8WVK4|intact:EBI-1237448|uniprotkb:Q6FG33|ensembl:ENSP00000220849	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:eif3e_human(display_long)|uniprotkb:EIF3E(gene name)|psi-mi:EIF3E(display_short)|uniprotkb:INT6(gene name synonym)|uniprotkb:EIF3S6(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 6(gene name synonym)|uniprotkb:eIF-3 p48(gene name synonym)|uniprotkb:Viral integration site protein INT-6 homolog(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001559.1|ensembl:ENSG00000104408(gene)|ensembl:ENST00000220849(transcript)|dip:DIP-32691N|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0016605"(PML body)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045296"(cadherin binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071540"(eukaryotic translation initiation factor 3 complex, eIF3e)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR016650(Translation initiation factor 3, subunit 6, eukaryotic)|interpro:IPR019010|interpro:IPR036390|mint:P60228|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6FEC|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:s09LicCa0mb9WwO7esZvVdvUonY9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q9BY44	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-1776615|uniprotkb:Q5QTR2|uniprotkb:Q7Z4E9|uniprotkb:Q8NFM1|uniprotkb:Q96EW9|uniprotkb:Q96K81|uniprotkb:A8MPS6|uniprotkb:B4DF96|uniprotkb:B4DQ14|uniprotkb:D3DNI9|ensembl:ENSP00000417229	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:eif2a_human(display_long)|uniprotkb:EIF2A(gene name)|psi-mi:EIF2A(display_short)|uniprotkb:CDA02(orf name)|uniprotkb:MSTP004(orf name)|uniprotkb:MSTP089(orf name)|uniprotkb:65 kDa eukaryotic translation initiation factor 2A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_114414.2|refseq:NP_001305972.1|refseq:NP_001305973.1|refseq:NP_001305974.1|refseq:NP_001305975.1|dip:DIP-40272N|ensembl:ENSG00000144895(gene)|ensembl:ENST00000460851(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0042255"(ribosome assembly)|go:"GO:0043022"(ribosome binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0072562"(blood microparticle)|go:"GO:1990928"(response to amino acid starvation)|interpro:IPR011387(Translation initiation factor eIF-2A)|interpro:IPR013979(Eukaryotic translation initiation factor 2A, central region)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|mint:Q9BY44	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:67hYEz0CrhoQ7SfXxZdOWqKzil89606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P38919	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-299104|ensembl:ENSP00000497641|ensembl:ENSP00000497661|uniprotkb:Q15033|uniprotkb:Q96A18|uniprotkb:Q6IBQ2	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:if4a3_human(display_long)|uniprotkb:KIAA0111(gene name synonym)|uniprotkb:EIF4A3(gene name)|psi-mi:EIF4A3(display_short)|uniprotkb:DDX48(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 4A isoform 3(gene name synonym)|uniprotkb:ATP-dependent RNA helicase eIF4A-3(gene name synonym)|uniprotkb:ATP-dependent RNA helicase DDX48(gene name synonym)|uniprotkb:DEAD box protein 48(gene name synonym)|uniprotkb:Eukaryotic initiation factor 4A-like NUK-34(gene name synonym)|uniprotkb:Nuclear matrix protein 265(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008306"(associative learning)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030425"(dendrite)|go:"GO:0035145"(exon-exon junction complex)|go:"GO:0035368"(selenocysteine insertion sequence binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0051028"(mRNA transport)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0072715"(cellular response to selenite ion)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1904570"(negative regulation of selenocysteine incorporation)|go:"GO:1904574"(negative regulation of selenocysteine insertion sequence binding)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P38919|rcsb pdb:2HXY|rcsb pdb:2HYI|rcsb pdb:2J0Q|rcsb pdb:2J0S|rcsb pdb:2J0U|rcsb pdb:2XB2|rcsb pdb:3EX7|rcsb pdb:4C9B|rcsb pdb:5MQF|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:6ICZ|rcsb pdb:6QDV|rcsb pdb:6YVH|rcsb pdb:7A5P|reactome:R-HSA-1169408|reactome:R-HSA-159236|reactome:R-HSA-429947|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|reactome:R-HSA-9010553|reactome:R-HSA-975957|ensembl:ENST00000647795(transcript)|ensembl:ENST00000649764(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|ensembl:ENSG00000141543(gene)|refseq:NP_055555.1|dip:DIP-33218N	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:8e6e4HlM1GsYqqgXyJ9XgzxLzls9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q96RP9	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-2255048|uniprotkb:B3KRW1|uniprotkb:A6NCI9|uniprotkb:B2RCB9|uniprotkb:Q6GTN2|uniprotkb:Q96T39|intact:EBI-2870814|ensembl:ENSP00000419038	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:efgm_human(display_long)|uniprotkb:GFM1(gene name)|psi-mi:GFM1(display_short)|uniprotkb:EFG(gene name synonym)|uniprotkb:EFG1(gene name synonym)|uniprotkb:GFM(gene name synonym)|uniprotkb:Elongation factor G 1, mitochondrial(gene name synonym)|uniprotkb:Elongation factor G1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001295093.1|refseq:NP_001295095.1|refseq:NP_079272.4|ensembl:ENSG00000168827(gene)|ensembl:ENST00000486715(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0070125"(mitochondrial translational elongation)|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR004540(Translation elongation factor EFG/EF2)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR005517(Translation elongation factor EFG/EF2, domain IV)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009022(Elongation factor G, III and V)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR027417|interpro:IPR031157|interpro:IPR035647|interpro:IPR035649|interpro:IPR041095|mint:Q96RP9|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6YDP|rcsb pdb:6YDW|rcsb pdb:7A5K|reactome:R-HSA-5389840	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:TwkylC5mlIaXRTw3hUyViUocC509606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P33991	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-374938|uniprotkb:Q8NEH1|uniprotkb:Q99658|ensembl:ENSP00000262105|ensembl:ENSP00000496964	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:mcm4_human(display_long)|uniprotkb:MCM4(gene name)|psi-mi:MCM4(display_short)|uniprotkb:CDC21(gene name synonym)|uniprotkb:CDC21 homolog(gene name synonym)|uniprotkb:P1-CDC21(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_005905.2|refseq:NP_877423.1|ensembl:ENSG00000104738(gene)|ensembl:ENST00000262105(transcript)|ensembl:ENST00000649973(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR001208(MCM)|interpro:IPR008047(MCM protein 4)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33991|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-31729N	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:emFkamsHmwBPzoJnPcaL4SaqAlU9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q86X95	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-627102|ensembl:ENSP00000339723|uniprotkb:A6NFI6|uniprotkb:A8K8M4|uniprotkb:O95367|uniprotkb:Q12804|uniprotkb:Q4G1B9|uniprotkb:Q6PJI4|uniprotkb:Q8IWI2	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:cir1_human(display_long)|uniprotkb:CIR(gene name synonym)|uniprotkb:CBF1-interacting corepressor(gene name synonym)|uniprotkb:Recepin(gene name synonym)|uniprotkb:CIR1(gene name)|psi-mi:CIR1(display_short)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENSG00000138433(gene)|ensembl:ENST00000342016(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR019339|interpro:IPR040014|mint:Q86X95|rcsb pdb:6ZYM|refseq:NP_004873.3	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:DMnBG746eQpvLsf9D+lgeUKnni09606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q9NUU7	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-740301|uniprotkb:Q53FM0|uniprotkb:B2RPL0|uniprotkb:B4DRZ7|ensembl:ENSP00000306117	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:dd19a_human(display_long)|uniprotkb:DEAD box protein 19A(gene name synonym)|uniprotkb:DDX19-like protein(gene name synonym)|uniprotkb:DDX19A(gene name)|psi-mi:DDX19A(display_short)|uniprotkb:DDX19L(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_060802.1|ensembl:ENSG00000168872(gene)|ensembl:ENST00000302243(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016973"("poly(A)+ mRNA export from nucleus")|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|refseq:NP_001307451.1|refseq:NP_001307454.1|refseq:NP_001307455.1|refseq:NP_001307456.1	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:Uvjex/lODTGHjNguDqyaquwkNaw9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P46777	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-358018|ensembl:ENSP00000359345|uniprotkb:Q53HH6|uniprotkb:Q9H3F4|uniprotkb:Q32LZ3	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:rl5_human(display_long)|uniprotkb:RPL5(gene name)|psi-mi:RPL5(display_short)|uniprotkb:Large ribosomal subunit protein uL18(gene name synonym)|uniprotkb:MSTP030(orf name)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0045202"(synapse)|ensembl:ENSG00000122406(gene)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|ensembl:ENST00000370321(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0010628"(positive regulation of gene expression)|refseq:NP_000960.2|dip:DIP-31152N|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000435"(negative regulation of protein neddylation)|interpro:IPR005485(Ribosomal protein L5, eukaryotic)|interpro:IPR025607|mint:P46777|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:rs+zAc+IPrEqv7DHNcy2GIkQkfY9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P18077	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-353383|uniprotkb:Q08ES9|uniprotkb:Q9BVN7|ensembl:ENSP00000393393|ensembl:ENSP00000495672	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:rl35a_human(display_long)|uniprotkb:RPL35A(gene name)|psi-mi:RPL35A(display_short)|uniprotkb:Cell growth-inhibiting gene 33 protein(gene name synonym)|uniprotkb:Large ribosomal subunit protein eL33(gene name synonym)|uniprotkb:GIG33(orf name)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_000987.2|refseq:NP_001303240.1|ensembl:ENST00000647248(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001780(Ribosomal protein L35Ae)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR018266|interpro:IPR038661|mint:P18077|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|ensembl:ENSG00000182899(gene)|ensembl:ENST00000448864(transcript)|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:fnUlL17LsiOp3lSkKNsoYO74IQQ9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P47914	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-714039|uniprotkb:Q6IPY3|ensembl:ENSP00000418346|ensembl:ENSP00000418868|ensembl:ENSP00000420673|ensembl:ENSP00000294189|ensembl:ENSP00000417048|ensembl:ENSP00000418153|uniprotkb:B2R4M8|uniprotkb:A8K0H3	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:rl29_human(display_long)|uniprotkb:Cell surface heparin-binding protein HIP(gene name synonym)|uniprotkb:RPL29(gene name)|psi-mi:RPL29(display_short)|uniprotkb:Large ribosomal subunit protein eL29(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENST00000294189(transcript)|ensembl:ENST00000466397(transcript)|ensembl:ENST00000475248(transcript)|ensembl:ENST00000479017(transcript)|ensembl:ENST00000492277(transcript)|ensembl:ENST00000495383(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0007566"(embryo implantation)|go:"GO:0008201"(heparin binding)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0045296"(cadherin binding)|interpro:IPR002673(Ribosomal protein L29e)|mint:P47914|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|ensembl:ENSG00000162244(gene)|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|refseq:NP_000983.1|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:XZUSMDDzycAi6QEXYbljXaeVg0U9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P46778	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-350634|uniprotkb:Q16699|ensembl:ENSP00000346027|ensembl:ENSP00000351021|ensembl:ENSP00000370569|ensembl:ENSP00000370574	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:rl21_human(display_long)|uniprotkb:RPL21(gene name)|psi-mi:RPL21(display_short)|uniprotkb:Large ribosomal subunit protein eL21(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	rcsb pdb:6LU8|refseq:NP_000973.2|ensembl:ENSG00000122026(gene)|ensembl:ENST00000272274(transcript)|ensembl:ENST00000311549(transcript)|ensembl:ENST00000319826(transcript)|ensembl:ENST00000326092(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|interpro:IPR001147(Ribosomal protein L21e)|interpro:IPR008991(Translation protein SH3-like)|interpro:IPR018259|interpro:IPR036948|mint:P46778|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6OLE|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:UCth+WL9Oj1Y9I5m4i/9X0a5WHk9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q02543	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-350523|ensembl:ENSP00000222247	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:rl18a_human(display_long)|uniprotkb:RPL18A(gene name)|psi-mi:RPL18A(display_short)|uniprotkb:Large ribosomal subunit protein eL20(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_000971.1|interpro:IPR021138|interpro:IPR023573|interpro:IPR028877|mint:Q02543|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|go:"GO:0097327"(response to antineoplastic agent)|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|ensembl:ENSG00000105640(gene)|ensembl:ENST00000222247(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|rcsb pdb:6ZME|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:O9XdW7Let2GcJpJLVuUtatVVv1I9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P30050	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-352743|uniprotkb:Q6PB27|uniprotkb:Q5VVV2|ensembl:ENSP00000354739	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:rl12_human(display_long)|uniprotkb:RPL12(gene name)|psi-mi:RPL12(display_short)|uniprotkb:Large ribosomal subunit protein uL11(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_000967.1|ensembl:ENSG00000197958(gene)|ensembl:ENST00000361436(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015934"(large ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070180"(large ribosomal subunit rRNA binding)|interpro:IPR000911(Ribosomal protein L11)|interpro:IPR020783|interpro:IPR020784|interpro:IPR020785|interpro:IPR036769|interpro:IPR036796|mint:P30050|rcsb pdb:4V6X|rcsb pdb:5A8L|rcsb pdb:5AJ0|rcsb pdb:6OLG|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:TNPEtl60cILofaPzUznvZiw6D7E9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P62906	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-356860|uniprotkb:P52859|uniprotkb:P53025|uniprotkb:Q5TZT6|uniprotkb:Q8J013|uniprotkb:B2R801|ensembl:ENSP00000363018	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:rl10a_human(display_long)|uniprotkb:RPL10A(gene name)|psi-mi:RPL10A(display_short)|uniprotkb:NEDD6(gene name synonym)|uniprotkb:CSA-19(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 6(gene name synonym)|uniprotkb:Large ribosomal subunit protein uL1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_009035.3|ensembl:ENSG00000198755(gene)|ensembl:ENST00000322203(transcript)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045471"(response to ethanol)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002143(Ribosomal protein L1)|interpro:IPR016095(Ribosomal protein L1, 3-layer alpha/beta-sandwich)|interpro:IPR023673|interpro:IPR023674|interpro:IPR028364|mint:P62906|rcsb pdb:4UG0|rcsb pdb:4V6X|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LU8|rcsb pdb:6OLG|rcsb pdb:6QZP|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:wrXKX6vzZ3ovXP3yUoL1/r+NGiw9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q9BYD2	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-726059|uniprotkb:Q9BSW8|uniprotkb:Q5SZR2|uniprotkb:B2RD99|ensembl:ENSP00000357823	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:rm09_human(display_long)|uniprotkb:MRPL9(gene name)|psi-mi:MRPL9(display_short)|uniprotkb:Mitochondrial large ribosomal subunit protein bL9m(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_113608.1|refseq:NP_001287662.1|ensembl:ENSG00000143436(gene)|ensembl:ENST00000368830(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0006412"(translation)|interpro:IPR000244(Ribosomal protein L9)|interpro:IPR009027(Ribosomal protein L9 N-terminal-like)|interpro:IPR020070|interpro:IPR036935|mint:Q9BYD2|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:JeHxoAdUc13d+0EnTCGBAa9rlVc9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q13405	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-5325200|ensembl:ENSP00000279242|ensembl:ENSP00000434190|uniprotkb:B2R4G6	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:rm49_human(display_long)|uniprotkb:Mitochondrial large ribosomal subunit protein mL49(gene name synonym)|uniprotkb:MRPL49(gene name)|psi-mi:MRPL49(display_short)|uniprotkb:C11orf4(gene name synonym)|uniprotkb:NOF1(gene name synonym)|uniprotkb:Neighbor of FAU(gene name synonym)|uniprotkb:Protein NOF1(gene name synonym)|uniprotkb:OK/SW-cl.67(orf name)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	interpro:IPR007740(Ribosomal protein L49/IMG2)|mint:Q13405|rcsb pdb:3J7Y|ensembl:ENSG00000149792(gene)|ensembl:ENST00000279242(transcript)|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|ensembl:ENST00000526319(transcript)|go:"GO:0003735"(structural constituent of ribosome)|rcsb pdb:6I9R|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005761"(mitochondrial ribosome)|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|go:"GO:0005762"(mitochondrial large ribosomal subunit)|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|go:"GO:0006412"(translation)|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|rcsb pdb:7OF6|reactome:R-HSA-5419276|refseq:NP_004918.1	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:rSs3oQ/ABEywPjx7fwVEuT6fsdQ9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P82933	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-721385|intact:EBI-1049991|uniprotkb:Q6PG40|ensembl:ENSP00000258455	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:rt09_human(display_long)|uniprotkb:MRPS9(gene name)|psi-mi:MRPS9(display_short)|uniprotkb:RPMS9(gene name synonym)|uniprotkb:Mitochondrial small ribosomal subunit protein uS9m(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_872578.1|ensembl:ENSG00000135972(gene)|ensembl:ENST00000258455(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|interpro:IPR000754(Ribosomal protein S9)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR020574|mint:P82933|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|rcsb pdb:6ZSE	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:XNB4GL84eYgYFEB3WxOtoD3Ub989606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P82650	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-1050752|ensembl:ENSP00000418008|ensembl:ENSP00000505414|uniprotkb:Q9H3I1	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:rt22_human(display_long)|uniprotkb:MRPS22(gene name)|psi-mi:MRPS22(display_short)|uniprotkb:C3orf5(gene name synonym)|uniprotkb:RPMS22(gene name synonym)|uniprotkb:GK002(orf name)|uniprotkb:Mitochondrial small ribosomal subunit protein mS22(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_064576.1|ensembl:ENSG00000175110(gene)|ensembl:ENST00000495075(transcript)|ensembl:ENST00000680020(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|interpro:IPR019374|mint:P82650|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:T0htF4/rvOZUZ3RcuCjWvEg9iTE9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:O43396	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-1048857|ensembl:ENSP00000217515|ensembl:ENSP00000464918	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:txnl1_human(display_long)|uniprotkb:32 kDa thioredoxin-related protein(gene name synonym)|uniprotkb:TXNL1(gene name)|psi-mi:TXNL1(display_short)|uniprotkb:TRP32(gene name synonym)|uniprotkb:TXL(gene name synonym)|uniprotkb:TXNL(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_004777.1|ensembl:ENSG00000091164(gene)|ensembl:ENST00000217515(transcript)|ensembl:ENST00000590954(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0015036"(disulfide oxidoreductase activity)|interpro:IPR008979(Galactose-binding like)|interpro:IPR010400(Protein of unknown function DUF1000)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017937|interpro:IPR036249|interpro:IPR037047|mint:O43396|rcsb pdb:1GH2|rcsb pdb:1WWY|reactome:R-HSA-9013418|reactome:R-HSA-9013420|reactome:R-HSA-9013422|reactome:R-HSA-9013424|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|refseq:XP_016881582.1	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:v3qpLTWgZZ1f4Tz/ixVYlSPv7Ro9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q8WWX9	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-10277687|uniprotkb:A8MPZ2|ensembl:ENSP00000383155|ensembl:ENSP00000384564	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:selm_human(display_long)|uniprotkb:SELENOM(gene name)|psi-mi:SELENOM(display_short)|uniprotkb:SELM(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_536355.1|ensembl:ENSG00000198832(gene)|ensembl:ENST00000400299(transcript)|ensembl:ENST00000402395(transcript)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0010269"(response to selenium ion)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035934"(corticosterone secretion)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060612"(adipose tissue development)|interpro:IPR014912(Sep15/SelM redox)|interpro:IPR036249|interpro:IPR038219|interpro:IPR039992	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:IQDdd35HYv6Zl49cWHoomVeh9Uk9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:O60613	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-1052797|uniprotkb:Q4GZG7|uniprotkb:Q8WU00|uniprotkb:Q9BS64|uniprotkb:Q9GZW0|uniprotkb:Q9NR01|ensembl:ENSP00000328729|uniprotkb:A0A0B4J1S4	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:sep15_human(display_long)|uniprotkb:SELENOF(gene name)|psi-mi:SELENOF(display_short)|uniprotkb:15 kDa selenoprotein(gene name synonym)|uniprotkb:SEP15(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_004252.2|refseq:NP_976086.1|mint:O60613|interpro:IPR039992|ensembl:ENSG00000183291(gene)|ensembl:ENST00000331835(transcript)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0051084"('de novo' posttranslational protein folding)|interpro:IPR014912(Sep15/SelM redox)|interpro:IPR036249|interpro:IPR038219	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:O+C59EK6dpYLDbHWrJT10RtGus89606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P09960	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-721089|uniprotkb:Q6IAT6|uniprotkb:Q9UCT7|uniprotkb:B4DNQ9|uniprotkb:F8VV40|ensembl:ENSP00000228740	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:lkha4_human(display_long)|uniprotkb:"Leukotriene A(4) hydrolase"(gene name synonym)|uniprotkb:LTA4H(gene name)|psi-mi:LTA4H(display_short)|uniprotkb:LTA4(gene name synonym)|uniprotkb:Tripeptide aminopeptidase LTA4H(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001243573.1|refseq:NP_000886.1|refseq:NP_001243572.1|refseq:XP_005268928.1|ensembl:ENSG00000111144(gene)|ensembl:ENST00000228740(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004301"(epoxide hydrolase activity)|go:"GO:0004463"(leukotriene-A4 hydrolase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0043171"(peptide catabolic process)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0070006"(metalloaminopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001930(Peptidase M1, membrane alanine aminopeptidase)|interpro:IPR012777(Leukotriene A-4 hydrolase/aminopeptidase)|interpro:IPR014782(Peptidase M1, membrane alanine aminopeptidase, N-terminal)|interpro:IPR015211(Peptidase M1, leukotriene A4 hydrolase, aminopeptidase C-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027268|interpro:IPR034015|interpro:IPR038502|interpro:IPR042097|mint:P09960|rcsb pdb:1GW6|rcsb pdb:1H19|rcsb pdb:1HS6|rcsb pdb:1SQM|rcsb pdb:2R59|rcsb pdb:2VJ8|rcsb pdb:3B7R|rcsb pdb:3B7S|rcsb pdb:3B7T|rcsb pdb:3B7U|rcsb pdb:3CHO|rcsb pdb:3CHP|rcsb pdb:3CHQ|rcsb pdb:3CHR|rcsb pdb:3CHS|rcsb pdb:3FH5|rcsb pdb:3FH7|rcsb pdb:3FH8|rcsb pdb:3FHE|rcsb pdb:3FTS|rcsb pdb:3FTU|rcsb pdb:3FTV|rcsb pdb:3FTW|go:"GO:0045148"(tripeptide aminopeptidase activity)|rcsb pdb:3FTX|rcsb pdb:3FTY|rcsb pdb:3FTZ|rcsb pdb:3FU0|rcsb pdb:3FU3|rcsb pdb:3FU5|rcsb pdb:3FU6|rcsb pdb:3FUD|rcsb pdb:3FUE|rcsb pdb:3FUF|rcsb pdb:3FUH|rcsb pdb:3FUI|rcsb pdb:3FUJ|rcsb pdb:3FUK|rcsb pdb:3FUL|rcsb pdb:3FUM|rcsb pdb:3FUN|rcsb pdb:3U9W|rcsb pdb:4DPR|rcsb pdb:4L2L|rcsb pdb:4MKT|rcsb pdb:4MS6|rcsb pdb:4R7L|rcsb pdb:4RSY|rcsb pdb:4RVB|rcsb pdb:5AEN|rcsb pdb:5BPP|rcsb pdb:5FWQ|rcsb pdb:5N3W|rcsb pdb:5NI2|rcsb pdb:5NI4|rcsb pdb:5NI6|rcsb pdb:5NIA|rcsb pdb:5NID|rcsb pdb:5NIE|rcsb pdb:6ENB|rcsb pdb:6ENC|rcsb pdb:6END|rcsb pdb:6O5H|rcsb pdb:7AUZ|rcsb pdb:7AV0|rcsb pdb:7AV1|rcsb pdb:7AV2|reactome:R-HSA-2142691|reactome:R-HSA-6798695|reactome:R-HSA-9018676|reactome:R-HSA-9018681|reactome:R-HSA-9018896|reactome:R-HSA-9020265|reactome:R-HSA-9023661	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:Qu84Rla6vl6zFvgcVCzHOa8mUbA9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P35754	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-3905236|uniprotkb:Q3KQS1|uniprotkb:B2R4L2|uniprotkb:Q6ICT1|ensembl:ENSP00000237858|ensembl:ENSP00000369314|ensembl:ENSP00000422708|ensembl:ENSP00000424636|ensembl:ENSP00000427353	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:glrx1_human(display_long)|uniprotkb:GLRX(gene name)|psi-mi:GLRX(display_short)|uniprotkb:GRX(gene name synonym)|uniprotkb:Thioltransferase-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001112362.1|refseq:NP_001230587.1|refseq:NP_001230588.1|refseq:NP_002055.1|ensembl:ENSG00000173221(gene)|ensembl:ENST00000237858(transcript)|ensembl:ENST00000379979(transcript)|ensembl:ENST00000505427(transcript)|ensembl:ENST00000508780(transcript)|ensembl:ENST00000512469(transcript)|go:"GO:0004362"("glutathione-disulfide reductase (NADPH) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0015038"(glutathione disulfide oxidoreductase activity)|go:"GO:0015949"(nucleobase-containing small molecule interconversion)|go:"GO:0045838"(positive regulation of membrane potential)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0080058"(protein deglutathionylation)|go:"GO:0097573"(glutathione oxidoreductase activity)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|interpro:IPR002109(Glutaredoxin)|interpro:IPR011767(Glutaredoxin active site)|interpro:IPR011899(Glutaredoxin, eukaryotic and viruses)|interpro:IPR014025(Glutaredoxin subgroup)|interpro:IPR036249|rcsb pdb:1B4Q|rcsb pdb:1JHB|rcsb pdb:4RQR|reactome:R-HSA-499943	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:TuN1okhO+Dk2jJYF8F8l4I9jqZQ9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P00568	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-1044943|uniprotkb:Q9BVK9|uniprotkb:Q9UQC7|ensembl:ENSP00000362249|ensembl:ENSP00000494600	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:kad1_human(display_long)|uniprotkb:ATP-AMP transphosphorylase 1(gene name synonym)|uniprotkb:Myokinase(gene name synonym)|uniprotkb:AK1(gene name)|psi-mi:AK1(display_short)|uniprotkb:"ATP:AMP phosphotransferase"(gene name synonym)|uniprotkb:Adenylate monophosphate kinase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_000467.1|ensembl:ENSG00000106992(gene)|ensembl:ENST00000373156(transcript)|ensembl:ENST00000644144(transcript)|go:"GO:0001520"(outer dense fiber)|go:"GO:0004017"(adenylate kinase activity)|go:"GO:0004550"(nucleoside diphosphate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006165"(nucleoside diphosphate phosphorylation)|go:"GO:0006172"(ADP biosynthetic process)|go:"GO:0009142"(nucleoside triphosphate biosynthetic process)|go:"GO:0015949"(nucleobase-containing small molecule interconversion)|go:"GO:0046033"(AMP metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000850(Adenylate kinase)|interpro:IPR006267(Adenylate kinase, isozyme 1)|interpro:IPR027417|interpro:IPR028582|interpro:IPR033690|rcsb pdb:1Z83|rcsb pdb:2C95|reactome:R-HSA-499943|refseq:NP_001305050.1|refseq:XP_016869916.1|refseq:XP_016869917.1	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:8Y034djIlviAtsKOQZj0TO89E+49606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P55263	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-1384340|uniprotkb:B7Z800|uniprotkb:O00741|uniprotkb:O00742|uniprotkb:Q16710|uniprotkb:Q9BTN2|uniprotkb:Q5JQ11|uniprotkb:B7Z783|uniprotkb:Q5JQ10|ensembl:ENSP00000443965	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:adk_human(display_long)|uniprotkb:Adenosine 5'-phosphotransferase(gene name synonym)|uniprotkb:ADK(gene name)|psi-mi:ADK(display_short)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001114.2|refseq:NP_001189378.1|refseq:NP_006712.2|refseq:NP_001189379.1|ensembl:ENSG00000156110(gene)|ensembl:ENST00000539909(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004001"(adenosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006175"(dATP biosynthetic process)|go:"GO:0009156"(ribonucleoside monophosphate biosynthetic process)|go:"GO:0044209"(AMP salvage)|go:"GO:0046872"(metal ion binding)|interpro:IPR001805(Adenosine kinase)|interpro:IPR002173(Carbohydrate/puine kinase, PfkB, conserved site)|interpro:IPR011611(Carbohydrate/purine kinase)|interpro:IPR029056|rcsb pdb:1BX4|rcsb pdb:2I6A|rcsb pdb:2I6B|rcsb pdb:4O1L|reactome:R-HSA-74217|go:"GO:0006166"(purine ribonucleoside salvage)	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:YiapVEW3Fq83fwNLkIwwnJxFYzE9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P18206	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-716775|uniprotkb:Q16450|uniprotkb:Q5SWX2|uniprotkb:Q7Z3B8|uniprotkb:Q8IXU7|ensembl:ENSP00000211998	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:vinc_human(display_long)|uniprotkb:Metavinculin(gene name synonym)|uniprotkb:VCL(gene name)|psi-mi:VCL(display_short)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_003364.1|refseq:NP_054706.1|ensembl:ENSG00000035403(gene)|ensembl:ENST00000211998(transcript)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0002102"(podosome)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0003779"(actin binding)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR017997|interpro:IPR036723|mint:P18206|rcsb pdb:1RKC|rcsb pdb:1RKE|rcsb pdb:1SYQ|rcsb pdb:1TR2|rcsb pdb:1YDI|rcsb pdb:2GWW|rcsb pdb:2HSQ|rcsb pdb:2IBF|rcsb pdb:3H2U|rcsb pdb:3H2V|rcsb pdb:3JBK|rcsb pdb:3MYI|rcsb pdb:3RF3|rcsb pdb:3S90|go:"GO:0005198"(structural molecule activity)|rcsb pdb:3TJ5|rcsb pdb:3TJ6|rcsb pdb:3VF0|rcsb pdb:4DJ9|rcsb pdb:4EHP|rcsb pdb:4LN2|rcsb pdb:4LNP|rcsb pdb:4PR9|rcsb pdb:5L0C|rcsb pdb:5L0D|rcsb pdb:5L0F|rcsb pdb:5L0G|rcsb pdb:5L0H|rcsb pdb:5L0I|rcsb pdb:5L0J|rcsb pdb:5O2Q|rcsb pdb:6FUY|rcsb pdb:6UPW|rcsb pdb:7KTT|rcsb pdb:7KTU|rcsb pdb:7KTV|rcsb pdb:7KTW|reactome:R-HSA-114608|reactome:R-HSA-445355|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005916"(fascia adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030055"(cell-substrate junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0043297"(apical junction assembly)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045121"(membrane raft)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048675"(axon extension)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0090636"(outer dense plaque of desmosome)|go:"GO:0090637"(inner dense plaque of desmosome)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1904702"(regulation of protein localization to adherens junction)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1990357"(terminal web)|interpro:IPR000633(Vinculin, conserved site)|ensembl:ENSP00000211998|ensembl:ENST00000372755|ensembl:ENSP00000361841|dip:DIP-35570N	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:Cs5ZD4u5mH3IHBeKWMRV4cfS+y49606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P07437	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-350864|uniprotkb:P05218|uniprotkb:Q8WUC1|uniprotkb:Q9CY33|ensembl:ENSP00000339001|ensembl:ENSP00000373058|ensembl:ENSP00000399155|ensembl:ENSP00000400663|ensembl:ENSP00000401317|ensembl:ENSP00000406811|ensembl:ENSP00000410071|ensembl:ENSP00000410829	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:tbb5_human(display_long)|uniprotkb:TUBB(gene name)|psi-mi:TUBB(display_short)|uniprotkb:Tubulin beta-5 chain(gene name synonym)|uniprotkb:TUBB5(gene name synonym)|uniprotkb:OK/SW-cl.56(orf name)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_821133.1|refseq:NP_001280141.1|refseq:NP_001280142.1|refseq:NP_001280143.1|refseq:NP_001280144.1|refseq:NP_001280145.1|ensembl:ENSG00000183311(gene)|ensembl:ENSG00000196230(gene)|ensembl:ENSG00000224156(gene)|ensembl:ENSG00000227739(gene)|ensembl:ENSG00000229684(gene)|ensembl:ENSG00000232421(gene)|ensembl:ENSG00000232575(gene)|ensembl:ENSG00000235067(gene)|ensembl:ENST00000327892(transcript)|ensembl:ENST00000383564(transcript)|ensembl:ENST00000419792(transcript)|ensembl:ENST00000421473(transcript)|ensembl:ENST00000422650(transcript)|ensembl:ENST00000422674(transcript)|ensembl:ENST00000432462(transcript)|ensembl:ENST00000436628(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0009987"(cellular process)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P07437|rcsb pdb:3QNZ|rcsb pdb:3QO0|rcsb pdb:5N5N|rcsb pdb:6I2I|rcsb pdb:6QUS|rcsb pdb:6QUY|rcsb pdb:6QVE|rcsb pdb:6QVJ|reactome:R-HSA-2565942|go:"GO:0050807"(regulation of synapse organization)|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-5620912|reactome:R-HSA-6798695|reactome:R-HSA-8854518|reactome:R-HSA-9679191|reactome:R-HSA-380320|dip:DIP-32772N	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:B6pmb1dvCroZXGd/1Zazi+s72GA9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P68363	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-487083|intact:EBI-1384226|uniprotkb:P04687|uniprotkb:P05209|uniprotkb:Q27I68|ensembl:ENSP00000336799|uniprotkb:Q8WU19	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:tba1b_human(display_long)|uniprotkb:TUBA1B(gene name)|psi-mi:TUBA1B(display_short)|uniprotkb:Tubulin alpha-ubiquitous chain(gene name synonym)|uniprotkb:Alpha-tubulin ubiquitous(gene name synonym)|uniprotkb:Tubulin K-alpha-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_006073.2|ensembl:ENSG00000123416(gene)|ensembl:ENST00000336023(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031625"(ubiquitin protein ligase binding)|reactome:R-HSA-983189|go:"GO:0071353"(cellular response to interleukin-4)|interpro:IPR000217(Tubulin)|go:"GO:0045121"(membrane raft)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P68363|rcsb pdb:2E4H|rcsb pdb:5IJ0|rcsb pdb:5IJ9|rcsb pdb:5N5N|rcsb pdb:6E7B|rcsb pdb:6E7C|rcsb pdb:6I2I|go:"GO:0051301"(cell division)|rcsb pdb:6J4V|rcsb pdb:6J8O|rcsb pdb:6QUS|rcsb pdb:6QUY|rcsb pdb:6QVE|rcsb pdb:6QVJ|rcsb pdb:6S8L|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|reactome:R-HSA-9013407|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-2132295|reactome:R-HSA-9668328	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:D4YpuLCXl/S+53qV7P7sF81aARY9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P06753	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-355607|uniprotkb:P12324|uniprotkb:Q969Q2|uniprotkb:Q9NQH8|uniprotkb:Q5VU71|uniprotkb:Q2QD06|uniprotkb:D3DV71|ensembl:ENSP00000498577|intact:EBI-11063811|uniprotkb:Q5VU66|uniprotkb:Q5VU72|intact:EBI-4289841|uniprotkb:Q5VU58|uniprotkb:Q5VU63|uniprotkb:Q8TCG3	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:tpm3_human(display_long)|uniprotkb:TPM3(gene name)|psi-mi:TPM3(display_short)|uniprotkb:Tropomyosin-3(gene name synonym)|uniprotkb:Gamma-tropomyosin(gene name synonym)|uniprotkb:Tropomyosin-5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001265120.1|refseq:NP_001036816.1|refseq:NP_001036817.1|refseq:NP_689476.2|refseq:NP_705935.1|ensembl:ENSG00000143549(gene)|ensembl:ENST00000651641(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005862"(muscle thin filament tropomyosin)|go:"GO:0005884"(actin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000533(Tropomyosin)|mint:P06753|rcsb pdb:6OTN|reactome:R-HSA-390522|reactome:R-HSA-445355|reactome:R-HSA-9013424|refseq:NP_001036818.1|refseq:NP_001265118.1	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:vHELhEyfZxpK8zHMEveODiYBZmM9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P09493	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-351158|uniprotkb:P09494|uniprotkb:P10469|uniprotkb:Q86W64|uniprotkb:Q96IK2|uniprotkb:Q9Y427|uniprotkb:Q9UCY9|uniprotkb:Q6DV89|uniprotkb:Q6DV90|uniprotkb:Q9UCI1|uniprotkb:Q9UCI2|uniprotkb:B7Z5T7|uniprotkb:Q7Z6L8|intact:EBI-2558177|ensembl:ENSP00000385107|intact:EBI-11030042|uniprotkb:D9YZV2|uniprotkb:D9YZV3|uniprotkb:D9YZV8	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:tpm1_human(display_long)|uniprotkb:TPM1(gene name)|psi-mi:TPM1(display_short)|uniprotkb:TMSA(gene name synonym)|uniprotkb:Tropomyosin-1(gene name synonym)|uniprotkb:Alpha-tropomyosin(gene name synonym)|uniprotkb:C15orf13(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_000357.3|refseq:NP_001018005.1|refseq:NP_001018006.1|refseq:NP_001018008.1|ensembl:ENSG00000140416(gene)|ensembl:ENST00000403994(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003065"(positive regulation of heart rate by epinephrine)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005862"(muscle thin filament tropomyosin)|go:"GO:0005884"(actin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030017"(sarcomere)|go:"GO:0030049"(muscle filament sliding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031529"(ruffle organization)|go:"GO:0032059"(bleb)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|interpro:IPR000533(Tropomyosin)|mint:P09493|rcsb pdb:3MUD|rcsb pdb:5KHT|rcsb pdb:6UT2|rcsb pdb:6X5Z|reactome:R-HSA-390522|reactome:R-HSA-445355|go:"GO:0042803"(protein homodimerization activity)|refseq:NP_001288173.1|refseq:NP_001018007.1|refseq:NP_001018004.1|refseq:NP_001018020.1|refseq:XP_016878027.1|refseq:NP_001317273.1|refseq:NP_001317275.1|refseq:NP_001317280.1	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:rsKuZnKpbEqVOpYBz3PnoSBCSHs9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P63313	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-2688673|uniprotkb:Q596K9|uniprotkb:P13472|ensembl:ENSP00000233143	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:tyb10_human(display_long)|uniprotkb:PTMB10(gene name synonym)|uniprotkb:THYB10(gene name synonym)|uniprotkb:TMSB10(gene name)|psi-mi:TMSB10(display_short)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_066926.1|ensembl:ENSG00000034510(gene)|ensembl:ENST00000233143(transcript)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007015"(actin filament organization)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0042989"(sequestering of actin monomers)|interpro:IPR001152(Thymosin beta-4)|interpro:IPR038386	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:oyHgjBTa5Wd0RSnF3dTUPsgPV9w9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q9UBP0	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-1222832|uniprotkb:Q9UPR9|uniprotkb:A7E2A7|ensembl:ENSP00000320885	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:spast_human(display_long)|uniprotkb:SPAST(gene name)|psi-mi:SPAST(display_short)|uniprotkb:KIAA1083(gene name synonym)|uniprotkb:SPG4(gene name synonym)|uniprotkb:ADPSP(gene name synonym)|uniprotkb:FSP2(gene name synonym)|uniprotkb:Spastic paraplegia 4 protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_055761.2|refseq:NP_955468.1|dip:DIP-38418N|ensembl:ENSG00000021574(gene)|ensembl:ENST00000315285(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007084"(mitotic nuclear membrane reassembly)|go:"GO:0007409"(axonogenesis)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008152"(metabolic process)|go:"GO:0008568"(microtubule-severing ATPase activity)|go:"GO:0010458"(exit from mitosis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0030496"(midbody)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031468"(nuclear membrane reassembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032506"(cytokinetic process)|go:"GO:0034214"(protein hexamerization)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051013"(microtubule severing)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|rcsb pdb:6PEN|go:"GO:0070062"(extracellular exosome)|reactome:R-HSA-9668328|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0090148"(membrane fission)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR007330(MIT)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR017179(Spastin)|interpro:IPR027417|interpro:IPR035106|interpro:IPR041569|rcsb pdb:3EAB|rcsb pdb:3VFD|rcsb pdb:5Z6Q|rcsb pdb:5Z6R|rcsb pdb:6PEK	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:E8b4FF6pWwyVd9teIInSCY4RzQE9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:O96013	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-713738|uniprotkb:Q8N4E1|uniprotkb:Q8NCH5|uniprotkb:Q8NDE3|uniprotkb:Q9BU33|uniprotkb:Q9ULS8|uniprotkb:B4DGG6|ensembl:ENSP00000351049|ensembl:ENSP00000353625|ensembl:ENSP00000469413	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:pak4_human(display_long)|uniprotkb:p21-activated kinase 4(gene name synonym)|uniprotkb:PAK4(gene name)|psi-mi:PAK4(display_short)|uniprotkb:KIAA1142(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	rcsb pdb:4FIF|rcsb pdb:4FIG|rcsb pdb:4FIH|rcsb pdb:4FII|rcsb pdb:4FIJ|rcsb pdb:4JDH|rcsb pdb:4JDI|rcsb pdb:4JDJ|rcsb pdb:4JDK|rcsb pdb:4L67|rcsb pdb:4NJD|rcsb pdb:4O0V|rcsb pdb:4O0X|rcsb pdb:4O0Y|rcsb pdb:4XBR|rcsb pdb:4XBU|rcsb pdb:5BMS|rcsb pdb:5I0B|rcsb pdb:5UPK|rcsb pdb:5UPL|rcsb pdb:5VED|rcsb pdb:5VEE|rcsb pdb:5VEF|rcsb pdb:5XVA|rcsb pdb:5XVF|rcsb pdb:5XVG|rcsb pdb:5ZJW|rcsb pdb:6WLX|rcsb pdb:6WLY|reactome:R-HSA-428540|reactome:R-HSA-9013148|reactome:R-HSA-9013149|rcsb pdb:4FIE|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013423|ensembl:ENSG00000130669(gene)|ensembl:ENST00000358301(transcript)|ensembl:ENST00000360442(transcript)|ensembl:ENST00000593690(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0016477"(cell migration)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR036936|mint:O96013|go:"GO:0032147"(activation of protein kinase activity)|rcsb pdb:2BVA|rcsb pdb:2CDZ|rcsb pdb:2J0I|rcsb pdb:2OV2|rcsb pdb:2Q0N|rcsb pdb:2X4Z|rcsb pdb:4APP|refseq:NP_001014831.1|refseq:NP_001014832.1|refseq:NP_001014834.1|refseq:NP_001014835.1|refseq:NP_005875.1|refseq:XP_011524618.1|refseq:XP_011524619.1|refseq:XP_011524620.1|refseq:XP_011524621.1|refseq:XP_011524622.1|dip:DIP-39742N	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:8i8hHt/Taj+czkueFRAMhdiMkYw9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:O95747	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-620853|intact:EBI-28983016|ensembl:ENSP00000311713|uniprotkb:Q3LR53|uniprotkb:Q7Z501|uniprotkb:Q9UPQ1|intact:EBI-21354189	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:oxsr1_human(display_long)|uniprotkb:Oxidative stress-responsive 1 protein(gene name synonym)|uniprotkb:OXSR1(gene name)|psi-mi:OXSR1(display_short)|uniprotkb:OSR1(gene name synonym)|uniprotkb:KIAA1101(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENSG00000172939(gene)|ensembl:ENST00000311806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042802"(identical protein binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1990869"(cellular response to chemokine)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024678|interpro:IPR028749|mint:O95747|rcsb pdb:2V3S|rcsb pdb:2VWI|rcsb pdb:3DAK|ensembl:ENSP00000311713|refseq:NP_005100.1|dip:DIP-34977N	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:B/vq09Ygsvo5paZdMXlX9tyo7aE9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P67775	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-712311|ensembl:ENSP00000418447|uniprotkb:P05323|uniprotkb:P13197	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:pp2aa_human(display_long)|uniprotkb:PPP2CA(gene name)|psi-mi:PPP2CA(display_short)|uniprotkb:Replication protein C(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENSG00000113575(gene)|ensembl:ENST00000481195(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000922"(spindle pole)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007498"(mesoderm development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0010033"(response to organic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019932"(second-messenger-mediated signaling)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0050811"(GABA receptor binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904526"(regulation of microtubule binding)|go:"GO:1904528"(positive regulation of microtubule binding)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|mint:P67775|rcsb pdb:2IAE|rcsb pdb:2IE3|rcsb pdb:2IE4|rcsb pdb:2NPP|rcsb pdb:2NYL|rcsb pdb:2NYM|rcsb pdb:3C5W|rcsb pdb:3DW8|rcsb pdb:3FGA|rcsb pdb:3K7W|rcsb pdb:3P71|rcsb pdb:4I5L|rcsb pdb:4I5N|rcsb pdb:4IYP|rcsb pdb:4LAC|rcsb pdb:5W0W|rcsb pdb:6NTS|rcsb pdb:7CUN|rcsb pdb:7K36|reactome:R-HSA-113501|reactome:R-HSA-1295596|reactome:R-HSA-141444|reactome:R-HSA-163685|reactome:R-HSA-163767|reactome:R-HSA-180024|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2465910|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2995383|reactome:R-HSA-389513|reactome:R-HSA-432142|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|rcsb pdb:3K7V|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6804757|reactome:R-HSA-6811558|reactome:R-HSA-68877|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-9634600|reactome:R-HSA-9648025|reactome:R-HSA-975957|refseq:NP_002706.1|dip:DIP-29395N	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:Zynydo3YUFioN2iUl6oR0nVJ4YY9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q7KZI7	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-516560|uniprotkb:Q15449|uniprotkb:Q15524|uniprotkb:Q5XGA3|uniprotkb:Q68A18|uniprotkb:Q96HB3|uniprotkb:Q96RG0|ensembl:ENSP00000385751	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:mark2_human(display_long)|uniprotkb:MAP/microtubule affinity-regulating kinase 2(gene name synonym)|uniprotkb:ELKL motif kinase 1(gene name synonym)|uniprotkb:PAR1 homolog(gene name synonym)|uniprotkb:MARK2(gene name)|psi-mi:MARK2(display_short)|uniprotkb:EMK1(gene name synonym)|uniprotkb:PAR1 homolog b(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001034558.2|refseq:NP_001156768.1|refseq:NP_001156769.1|refseq:NP_004945.4|refseq:NP_059672.2|dip:DIP-31321N|ensembl:ENSG00000072518(gene)|ensembl:ENST00000402010(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001764"(neuron migration)|go:"GO:0003723"(RNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008289"(lipid binding)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030425"(dendrite)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0061564"(axon development)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071963"(establishment or maintenance of cell polarity regulating cell shape)|go:"GO:0097427"(microtubule bundle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904526"(regulation of microtubule binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|mint:Q7KZI7|rcsb pdb:3IEC|rcsb pdb:5EAK|rcsb pdb:5KZ7|rcsb pdb:5KZ8	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:yfUqSCu4bgkncBd6hRRg5pKkArc9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q14141	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-745901|uniprotkb:Q5JTK0|uniprotkb:Q969W5|uniprotkb:Q96A13|uniprotkb:Q96GR1|uniprotkb:Q96P86|uniprotkb:Q96P87|intact:EBI-1047521|ensembl:ENSP00000341524	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:sept6_human(display_long)|uniprotkb:SEPTIN6(gene name)|psi-mi:SEPTIN6(display_short)|uniprotkb:KIAA0128(gene name synonym)|uniprotkb:SEP2(gene name synonym)|uniprotkb:SEPT6(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENSG00000125354(gene)|ensembl:ENST00000343984(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005819"(spindle)|go:"GO:0005940"(septin ring)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030154"(cell differentiation)|go:"GO:0030496"(midbody)|go:"GO:0031105"(septin complex)|go:"GO:0032153"(cell division site)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032173"(septin collar)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043679"(axon terminus)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0097227"(sperm annulus)|interpro:IPR016491(Septin)|interpro:IPR027417|interpro:IPR030379|interpro:IPR030644|mint:Q14141|rcsb pdb:2QAG|rcsb pdb:6UPA|rcsb pdb:6WBP|refseq:NP_055944.2|refseq:NP_665798.1|refseq:NP_665799.1|refseq:NP_665801.1|refseq:XP_006724813.1|dip:DIP-38218N	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:gH1JHXyE/7o3I8i4ZS3bMoF7zvU9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q96DB5	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-2564644|uniprotkb:A9UMZ8|uniprotkb:Q9Y398|ensembl:ENSP00000385927|uniprotkb:B4DNF5|uniprotkb:E7EVI2|uniprotkb:B4DZW6|uniprotkb:B5MC61|uniprotkb:C9JSC6	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:rmd1_human(display_long)|uniprotkb:RMDN1(gene name)|psi-mi:RMDN1(display_short)|uniprotkb:FAM82B(gene name synonym)|uniprotkb:Protein FAM82B(gene name synonym)|uniprotkb:CGI-90(orf name)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001273648.1|refseq:NP_057117.2|refseq:NP_001304736.1|ensembl:ENSG00000176623(gene)|ensembl:ENST00000406452(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005876"(spindle microtubule)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR011990(Tetratricopeptide-like helical)|mint:Q96DB5|refseq:NP_001273636.1	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:EAYrDAOf2NP9wZLfqd3rmwSV5uc9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P58546	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-1051736|ensembl:ENSP00000376800	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:mtpn_human(display_long)|uniprotkb:Protein V-1(gene name synonym)|uniprotkb:MTPN(gene name)|psi-mi:MTPN(display_short)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_665807.1|ensembl:ENSG00000105887(gene)|ensembl:ENST00000393085(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006417"(regulation of translation)|go:"GO:0006584"(catecholamine metabolic process)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010557"(positive regulation of macromolecule biosynthetic process)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0021707"(cerebellar granule cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:2000812"(regulation of barbed-end actin filament capping)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|mint:P58546|rcsb pdb:3AAA|rcsb pdb:7DF7|rcsb pdb:7DSA|rcsb pdb:7DSB|dip:DIP-50234N	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:kdJ8vNN4yI2ye49iYUNAtH538b49606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P35579	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-350338|uniprotkb:O60805|ensembl:ENSP00000216181|uniprotkb:Q86T83|intact:EBI-1054343|uniprotkb:A8K6E4|uniprotkb:Q60FE2	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:myh9_human(display_long)|uniprotkb:MYH9(gene name)|psi-mi:MYH9(display_short)|uniprotkb:Myosin heavy chain 9(gene name synonym)|uniprotkb:Myosin heavy chain, non-muscle IIa(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain IIa(gene name synonym)|uniprotkb:Cellular myosin heavy chain, type A(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_002464.1|ensembl:ENSG00000100345(gene)|ensembl:ENST00000216181(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001772"(immunological synapse)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0001931"(uropod)|go:"GO:0003723"(RNA binding)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005826"(actomyosin contractile ring)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015031"(protein transport)|refseq:XP_011528499.1|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016460"(myosin II complex)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030220"(platelet formation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032418"(lysosome localization)|go:"GO:0032506"(cytokinetic process)|go:"GO:0032796"(uropod organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045296"(cadherin binding)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051015"(actin filament binding)|go:"GO:0051295"(establishment of meiotic spindle localization)|go:"GO:0060471"(cortical granule exocytosis)|go:"GO:0060473"(cortical granule)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0097513"(myosin II filament)|go:"GO:1903919"(negative regulation of actin filament severing)|rcsb pdb:4CFR|rcsb pdb:4ETO|reactome:R-HSA-1445148|reactome:R-HSA-2029482|reactome:R-HSA-3928663|reactome:R-HSA-416572|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|reactome:R-HSA-9662360|reactome:R-HSA-9662361|reactome:R-HSA-9662834|reactome:R-HSA-9664422|go:"GO:1903923"(positive regulation of protein processing in phagocytic vesicle)|go:"GO:1905684"(regulation of plasma membrane repair)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR036305|interpro:IPR036961|mint:P35579|rcsb pdb:2LNK|rcsb pdb:3ZWH|rcsb pdb:4CFQ|refseq:XP_016884292.1|refseq:XP_016884293.1|refseq:XP_016884294.1|refseq:XP_016884295.1|dip:DIP-33103N	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:fSOtpFpr8PSnAG5UdAr/khwkzJs9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q7Z406	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-355595|uniprotkb:Q5CZ75|uniprotkb:Q6XYE4|uniprotkb:Q76B62|uniprotkb:Q8WV23|uniprotkb:Q96I22|uniprotkb:Q9BT27|uniprotkb:Q9BW35|uniprotkb:Q9H882|uniprotkb:B0I1S2|ensembl:ENSP00000366169|ensembl:ENSP00000472819|uniprotkb:C3TTN4	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:myh14_human(display_long)|uniprotkb:MYH14(gene name)|psi-mi:MYH14(display_short)|uniprotkb:KIAA2034(gene name synonym)|uniprotkb:FP17425(orf name)|uniprotkb:Myosin heavy chain 14(gene name synonym)|uniprotkb:Myosin heavy chain, non-muscle IIc(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain IIc(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001070654.1|refseq:NP_001139281.1|refseq:NP_079005.3|refseq:XP_011525625.1|ensembl:ENSG00000105357(gene)|ensembl:ENST00000376970(transcript)|ensembl:ENST00000596571(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0001725"(stress fiber)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016020"(membrane)|go:"GO:0016460"(myosin II complex)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030426"(growth cone)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0042641"(actomyosin)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097513"(myosin II filament)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR036961|mint:Q7Z406|rcsb pdb:5I4E|rcsb pdb:5JLH|reactome:R-HSA-3928663|reactome:R-HSA-416572|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|interpro:IPR002928(Myosin tail)|refseq:XP_006723449.1|dip:DIP-33170N	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:6aY3HPa5DIY5UadiOTTh/uSPi/M9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q9BW19	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-2107279|uniprotkb:O60887|uniprotkb:Q14834|uniprotkb:Q4KMP0|uniprotkb:Q5SU09|uniprotkb:Q6GMS7|uniprotkb:Q6P4A5|uniprotkb:Q9UQP7|ensembl:ENSP00000363647|ensembl:ENSP00000393963|ensembl:ENSP00000407885	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:kifc1_human(display_long)|uniprotkb:KIFC1(gene name)|psi-mi:KIFC1(display_short)|uniprotkb:HSET(gene name synonym)|uniprotkb:KNSL2(gene name synonym)|uniprotkb:Kinesin-like protein 2(gene name synonym)|uniprotkb:Kinesin-related protein HSET(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_002254.2|ensembl:ENSG00000204197(gene)|ensembl:ENSG00000233450(gene)|ensembl:ENSG00000237649(gene)|ensembl:ENST00000374523(transcript)|ensembl:ENST00000428849(transcript)|ensembl:ENST00000448818(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008017"(microtubule binding)|go:"GO:0016020"(membrane)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR036961|mint:Q9BW19|rcsb pdb:5WDH|reactome:R-HSA-6811434|reactome:R-HSA-983189	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:2gWpNwZk9kWJGVvR8xLuDPJYP4M9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:O43707	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-351526|uniprotkb:O76048|uniprotkb:D6PXK4|ensembl:ENSP00000252699|ensembl:ENSP00000489220|uniprotkb:A4K467	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:actn4_human(display_long)|uniprotkb:ACTN4(gene name)|psi-mi:ACTN4(display_short)|uniprotkb:Non-muscle alpha-actinin 4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_004915.2|ensembl:ENSG00000130402(gene)|ensembl:ENSG00000282844(gene)|ensembl:ENST00000252699(transcript)|ensembl:ENST00000634960(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001882"(nucleoside binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0015031"(protein transport)|go:"GO:0016604"(nuclear body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031143"(pseudopodium)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032417"("positive regulation of sodium:proton antiporter activity")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035357"(peroxisome proliferator activated receptor signaling pathway)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903506"(regulation of nucleic acid-templated transcription)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR036872|mint:O43707|rcsb pdb:1WLX|rcsb pdb:1YDI|rcsb pdb:2R0O|rcsb pdb:6O31|rcsb pdb:6OA6|reactome:R-HSA-114608|reactome:R-HSA-373753|dip:DIP-33179N	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:kTYezA2lEtL/AQPfCQ8BE79nzow9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P61158	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-351428|uniprotkb:P32391|ensembl:ENSP00000263238|uniprotkb:Q53QM2	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:arp3_human(display_long)|uniprotkb:ACTR3(gene name)|psi-mi:ACTR3(display_short)|uniprotkb:ARP3(gene name synonym)|uniprotkb:Actin-like protein 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_005712.1|ensembl:ENSG00000115091(gene)|ensembl:ENST00000263238(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016344"(meiotic chromosome movement towards spindle pole)|go:"GO:0030027"(lamellipodium)|go:"GO:0033206"(meiotic cytokinesis)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051653"(spindle localization)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070358"(actin polymerization-dependent cell motility)|go:"GO:0071346"(cellular response to interferon-gamma)|interpro:IPR004000(Actin/actin-like)|interpro:IPR015623(Actin-related protein 3)|interpro:IPR020902|interpro:IPR043129|mint:P61158|rcsb pdb:6UHC|rcsb pdb:6YW6|rcsb pdb:6YW7|reactome:R-HSA-2029482|reactome:R-HSA-3928662|reactome:R-HSA-5663213|reactome:R-HSA-8856828|reactome:R-HSA-9664422|dip:DIP-33140N	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:XbkZeKzG8lGbT8dxYkGqeJT0vEg9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:O15511	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-352975|uniprotkb:A6NEC4|uniprotkb:Q6PG42|ensembl:ENSP00000352918	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:arpc5_human(display_long)|uniprotkb:ARPC5(gene name)|psi-mi:ARPC5(display_short)|uniprotkb:ARC16(gene name synonym)|uniprotkb:Arp2/3 complex 16 kDa subunit(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_005708.1|refseq:NP_001257368.1|dip:DIP-33144N|ensembl:ENSG00000162704(gene)|ensembl:ENST00000359856(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0014909"(smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0021769"(orbitofrontal cortex development)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030426"(growth cone)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035861"(site of double-strand break)|go:"GO:0051639"(actin filament network formation)|go:"GO:0061842"(microtubule organizing center localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097581"(lamellipodium organization)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR006789("ARP2/3 complex 16 kDa subunit (p16-Arc)")|interpro:IPR036743|mint:O15511|rcsb pdb:6UHC|rcsb pdb:6YW7|reactome:R-HSA-2029482|reactome:R-HSA-3928662|reactome:R-HSA-5663213|reactome:R-HSA-6798695|reactome:R-HSA-8856828|reactome:R-HSA-9664422	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:kfZQK6CXdREnQNI1h+GlQpB/gPI9606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:O15144	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-352356|uniprotkb:Q92801|uniprotkb:Q9P1D4|ensembl:ENSP00000295685|ensembl:ENSP00000327137	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:arpc2_human(display_long)|uniprotkb:ARPC2(gene name)|psi-mi:ARPC2(display_short)|uniprotkb:ARC34(gene name synonym)|uniprotkb:PRO2446(orf name)|uniprotkb:Arp2/3 complex 34 kDa subunit(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745135|imex:IM-28152-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_005722.1|refseq:NP_690601.1|go:"GO:0005925"(focal adhesion)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036195"(muscle cell projection membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070358"(actin polymerization-dependent cell motility)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR007188(Arp2/3 complex, 34kDa subunit p34-Arc)|interpro:IPR034666|mint:O15144|rcsb pdb:6UHC|rcsb pdb:6YW6|rcsb pdb:6YW7|reactome:R-HSA-2029482|go:"GO:0005885"(Arp2/3 protein complex)|reactome:R-HSA-5663213|reactome:R-HSA-8856828|reactome:R-HSA-9664422|reactome:R-HSA-3928662|ensembl:ENSG00000163466(gene)|ensembl:ENST00000295685(transcript)|ensembl:ENST00000315717(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|dip:DIP-33197N	-	-	-	figure legend:Table 1|comment:"Using the purified ΔN-HtrA4 protein as the bait in the pull-down  experiment and applying LC-MS technique we identified 167 tentative HtrA4 partners (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:v5OozQTt614rvrBBoUavbAzjgZ49606	rigid:deNK7GMNMCymfJi4yqWetgvfTgo	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q9NRY2	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-2881520|ensembl:ENSP00000363360|uniprotkb:Q5VWJ7|uniprotkb:Q96E04|uniprotkb:Q9P090	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:sossc_human(display_long)|uniprotkb:INIP(gene name)|psi-mi:INIP(display_short)|uniprotkb:C9orf80(gene name synonym)|uniprotkb:INTS3- and NABP-interacting protein(gene name synonym)|uniprotkb:SSBIP1(gene name synonym)|uniprotkb:Sensor of single-strand DNA complex subunit C(gene name synonym)|uniprotkb:Sensor of ssDNA subunit C(gene name synonym)|uniprotkb:Single-stranded DNA-binding protein-interacting protein 1(gene name synonym)|uniprotkb:HSPC043(orf name)|uniprotkb:HSPC291(orf name)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745183|imex:IM-28152-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENSG00000148153(gene)|ensembl:ENST00000374242(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0070876"(SOSS complex)|interpro:IPR031821|mint:Q9NRY2|rcsb pdb:4OWT|rcsb pdb:4OWW|refseq:NP_067041.1	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/01	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:1yTn7MGixuIKlmO+f3JXR1M4/UI9606	rigid:dpa9aAlidtikNH4m5YtN9WpK4WA	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q13217	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-6165721|ensembl:ENSP00000473631|uniprotkb:Q86WT9|uniprotkb:Q8N4N2	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:dnjc3_human(display_long)|uniprotkb:DNAJC3(gene name)|psi-mi:DNAJC3(display_short)|uniprotkb:Interferon-induced, double-stranded RNA-activated protein kinase inhibitor(gene name synonym)|uniprotkb:P58IPK(gene name synonym)|uniprotkb:PRKRI(gene name synonym)|uniprotkb:Protein kinase inhibitor of 58 kDa(gene name synonym)|uniprotkb:Endoplasmic reticulum DNA J domain-containing protein 6(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745183|imex:IM-28152-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENSG00000102580(gene)|ensembl:ENST00000602402(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0036494"(positive regulation of translation initiation in response to endoplasmic reticulum stress)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051607"(defense response to virus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070417"(cellular response to cold)|go:"GO:0051787"(misfolded protein binding)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR018704|interpro:IPR019734|interpro:IPR036869|rcsb pdb:2Y4T|rcsb pdb:2Y4U|reactome:R-HSA-192823|reactome:R-HSA-381038|reactome:R-HSA-381426|reactome:R-HSA-6798695|reactome:R-HSA-8957275|refseq:NP_006251.1	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/01	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:p5PToTl/u3ZL9PtRSjDK01FKJmc9606	rigid:dpa9aAlidtikNH4m5YtN9WpK4WA	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q32P51	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-2556580|uniprotkb:Q5TBS2|ensembl:ENSP00000350090	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:ra1l2_human(display_long)|uniprotkb:HNRNPA1L(gene name synonym)|uniprotkb:HNRNPA1L2(gene name)|psi-mi:HNRNPA1L2(display_short)|uniprotkb:hnRNP core protein A1-like 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745183|imex:IM-28152-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001011724.1|refseq:NP_001011725.1|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0051028"(mRNA transport)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR021662|interpro:IPR034803|interpro:IPR035979|mint:Q32P51|go:"GO:0005681"(spliceosomal complex)|ensembl:ENSG00000139675(gene)|ensembl:ENST00000357495(transcript)|go:"GO:0003723"(RNA binding)	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/01	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:Xx00SLimJrf+0e9CrvzUV9PJPcI9606	rigid:dpa9aAlidtikNH4m5YtN9WpK4WA	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P51114	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745183|imex:IM-28152-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/01	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rigid:dpa9aAlidtikNH4m5YtN9WpK4WA	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q86X95	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-627102|ensembl:ENSP00000339723|uniprotkb:A6NFI6|uniprotkb:A8K8M4|uniprotkb:O95367|uniprotkb:Q12804|uniprotkb:Q4G1B9|uniprotkb:Q6PJI4|uniprotkb:Q8IWI2	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:cir1_human(display_long)|uniprotkb:CIR(gene name synonym)|uniprotkb:CBF1-interacting corepressor(gene name synonym)|uniprotkb:Recepin(gene name synonym)|uniprotkb:CIR1(gene name)|psi-mi:CIR1(display_short)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745183|imex:IM-28152-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENSG00000138433(gene)|ensembl:ENST00000342016(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR019339|interpro:IPR040014|mint:Q86X95|rcsb pdb:6ZYM|refseq:NP_004873.3	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/01	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:DMnBG746eQpvLsf9D+lgeUKnni09606	rigid:dpa9aAlidtikNH4m5YtN9WpK4WA	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P68363	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-487083|intact:EBI-1384226|uniprotkb:P04687|uniprotkb:P05209|uniprotkb:Q27I68|ensembl:ENSP00000336799|uniprotkb:Q8WU19	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:tba1b_human(display_long)|uniprotkb:TUBA1B(gene name)|psi-mi:TUBA1B(display_short)|uniprotkb:Tubulin alpha-ubiquitous chain(gene name synonym)|uniprotkb:Alpha-tubulin ubiquitous(gene name synonym)|uniprotkb:Tubulin K-alpha-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745183|imex:IM-28152-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_006073.2|ensembl:ENSG00000123416(gene)|ensembl:ENST00000336023(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031625"(ubiquitin protein ligase binding)|reactome:R-HSA-983189|go:"GO:0071353"(cellular response to interleukin-4)|interpro:IPR000217(Tubulin)|go:"GO:0045121"(membrane raft)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P68363|rcsb pdb:2E4H|rcsb pdb:5IJ0|rcsb pdb:5IJ9|rcsb pdb:5N5N|rcsb pdb:6E7B|rcsb pdb:6E7C|rcsb pdb:6I2I|go:"GO:0051301"(cell division)|rcsb pdb:6J4V|rcsb pdb:6J8O|rcsb pdb:6QUS|rcsb pdb:6QUY|rcsb pdb:6QVE|rcsb pdb:6QVJ|rcsb pdb:6S8L|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|reactome:R-HSA-9013407|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-2132295|reactome:R-HSA-9668328	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/01	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:D4YpuLCXl/S+53qV7P7sF81aARY9606	rigid:dpa9aAlidtikNH4m5YtN9WpK4WA	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q9UBP0	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-1222832|uniprotkb:Q9UPR9|uniprotkb:A7E2A7|ensembl:ENSP00000320885	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:spast_human(display_long)|uniprotkb:SPAST(gene name)|psi-mi:SPAST(display_short)|uniprotkb:KIAA1083(gene name synonym)|uniprotkb:SPG4(gene name synonym)|uniprotkb:ADPSP(gene name synonym)|uniprotkb:FSP2(gene name synonym)|uniprotkb:Spastic paraplegia 4 protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745183|imex:IM-28152-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_055761.2|refseq:NP_955468.1|dip:DIP-38418N|ensembl:ENSG00000021574(gene)|ensembl:ENST00000315285(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007084"(mitotic nuclear membrane reassembly)|go:"GO:0007409"(axonogenesis)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008152"(metabolic process)|go:"GO:0008568"(microtubule-severing ATPase activity)|go:"GO:0010458"(exit from mitosis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0030496"(midbody)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031468"(nuclear membrane reassembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032506"(cytokinetic process)|go:"GO:0034214"(protein hexamerization)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051013"(microtubule severing)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|rcsb pdb:6PEN|go:"GO:0070062"(extracellular exosome)|reactome:R-HSA-9668328|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0090148"(membrane fission)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR007330(MIT)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR017179(Spastin)|interpro:IPR027417|interpro:IPR035106|interpro:IPR041569|rcsb pdb:3EAB|rcsb pdb:3VFD|rcsb pdb:5Z6Q|rcsb pdb:5Z6R|rcsb pdb:6PEK	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/01	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:E8b4FF6pWwyVd9teIInSCY4RzQE9606	rigid:dpa9aAlidtikNH4m5YtN9WpK4WA	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q7L7X3	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-1384314|uniprotkb:Q96L75|uniprotkb:Q9H2K7|uniprotkb:Q9H7S5|uniprotkb:Q9P2I6|uniprotkb:A2RUT8|uniprotkb:B7ZLV6|ensembl:ENSP00000261716	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:taok1_human(display_long)|uniprotkb:Prostate-derived sterile 20-like kinase 2(gene name synonym)|uniprotkb:Thousand and one amino acid protein kinase 1(gene name synonym)|uniprotkb:TAOK1(gene name)|psi-mi:TAOK1(display_short)|uniprotkb:KIAA1361(gene name synonym)|uniprotkb:MAP3K16(gene name synonym)|uniprotkb:MARKK(gene name synonym)|uniprotkb:MARK Kinase(gene name synonym)|uniprotkb:Kinase from chicken homolog B(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745183|imex:IM-28152-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:XP_011523362.1|refseq:NP_065842.1|refseq:NP_079418.1|dip:DIP-39709N|ensembl:ENSG00000160551(gene)|ensembl:ENST00000261716(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016740"(transferase activity)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901985"(positive regulation of protein acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/01	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:tfE56A9/KSEBu1lgTyvfrGC9kn89606	rigid:dpa9aAlidtikNH4m5YtN9WpK4WA	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q9BW19	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-2107279|uniprotkb:O60887|uniprotkb:Q14834|uniprotkb:Q4KMP0|uniprotkb:Q5SU09|uniprotkb:Q6GMS7|uniprotkb:Q6P4A5|uniprotkb:Q9UQP7|ensembl:ENSP00000363647|ensembl:ENSP00000393963|ensembl:ENSP00000407885	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:kifc1_human(display_long)|uniprotkb:KIFC1(gene name)|psi-mi:KIFC1(display_short)|uniprotkb:HSET(gene name synonym)|uniprotkb:KNSL2(gene name synonym)|uniprotkb:Kinesin-like protein 2(gene name synonym)|uniprotkb:Kinesin-related protein HSET(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745183|imex:IM-28152-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_002254.2|ensembl:ENSG00000204197(gene)|ensembl:ENSG00000233450(gene)|ensembl:ENSG00000237649(gene)|ensembl:ENST00000374523(transcript)|ensembl:ENST00000428849(transcript)|ensembl:ENST00000448818(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008017"(microtubule binding)|go:"GO:0016020"(membrane)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR036961|mint:Q9BW19|rcsb pdb:5WDH|reactome:R-HSA-6811434|reactome:R-HSA-983189	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/01	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:2gWpNwZk9kWJGVvR8xLuDPJYP4M9606	rigid:dpa9aAlidtikNH4m5YtN9WpK4WA	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:O96013	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-713738|uniprotkb:Q8N4E1|uniprotkb:Q8NCH5|uniprotkb:Q8NDE3|uniprotkb:Q9BU33|uniprotkb:Q9ULS8|uniprotkb:B4DGG6|ensembl:ENSP00000351049|ensembl:ENSP00000353625|ensembl:ENSP00000469413	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:pak4_human(display_long)|uniprotkb:p21-activated kinase 4(gene name synonym)|uniprotkb:PAK4(gene name)|psi-mi:PAK4(display_short)|uniprotkb:KIAA1142(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745183|imex:IM-28152-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	rcsb pdb:4FIF|rcsb pdb:4FIG|rcsb pdb:4FIH|rcsb pdb:4FII|rcsb pdb:4FIJ|rcsb pdb:4JDH|rcsb pdb:4JDI|rcsb pdb:4JDJ|rcsb pdb:4JDK|rcsb pdb:4L67|rcsb pdb:4NJD|rcsb pdb:4O0V|rcsb pdb:4O0X|rcsb pdb:4O0Y|rcsb pdb:4XBR|rcsb pdb:4XBU|rcsb pdb:5BMS|rcsb pdb:5I0B|rcsb pdb:5UPK|rcsb pdb:5UPL|rcsb pdb:5VED|rcsb pdb:5VEE|rcsb pdb:5VEF|rcsb pdb:5XVA|rcsb pdb:5XVF|rcsb pdb:5XVG|rcsb pdb:5ZJW|rcsb pdb:6WLX|rcsb pdb:6WLY|reactome:R-HSA-428540|reactome:R-HSA-9013148|reactome:R-HSA-9013149|rcsb pdb:4FIE|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013423|ensembl:ENSG00000130669(gene)|ensembl:ENST00000358301(transcript)|ensembl:ENST00000360442(transcript)|ensembl:ENST00000593690(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0016477"(cell migration)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR036936|mint:O96013|go:"GO:0032147"(activation of protein kinase activity)|rcsb pdb:2BVA|rcsb pdb:2CDZ|rcsb pdb:2J0I|rcsb pdb:2OV2|rcsb pdb:2Q0N|rcsb pdb:2X4Z|rcsb pdb:4APP|refseq:NP_001014831.1|refseq:NP_001014832.1|refseq:NP_001014834.1|refseq:NP_001014835.1|refseq:NP_005875.1|refseq:XP_011524618.1|refseq:XP_011524619.1|refseq:XP_011524620.1|refseq:XP_011524621.1|refseq:XP_011524622.1|dip:DIP-39742N	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/01	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:8i8hHt/Taj+czkueFRAMhdiMkYw9606	rigid:dpa9aAlidtikNH4m5YtN9WpK4WA	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:O75128	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-3446582|uniprotkb:A4D257|uniprotkb:B7ZLW9|uniprotkb:B9EGF8|uniprotkb:Q8TCM1|uniprotkb:Q8N304|uniprotkb:A7E2B0|uniprotkb:Q86XA7|uniprotkb:Q504Y4|uniprotkb:Q2T9J3|intact:EBI-28974386|ensembl:ENSP00000265136	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:cobl_human(display_long)|uniprotkb:COBL(gene name)|psi-mi:COBL(display_short)|uniprotkb:KIAA0633(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745183|imex:IM-28152-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENSP00000265136|ensembl:ENST00000395540|ensembl:ENSP00000378910|ensembl:ENST00000395542|ensembl:ENSP00000378912|ensembl:ENST00000441453|ensembl:ENSP00000399500|refseq:XP_011513537.1|refseq:NP_056013.2|refseq:NP_001274365.1|refseq:NP_001274367.1|refseq:NP_001333370.1|refseq:NP_001333371.1|refseq:NP_001333372.1|refseq:NP_001333373.1|ensembl:ENSG00000106078(gene)|ensembl:ENST00000265136(transcript)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0001726"(ruffle)|go:"GO:0001757"(somite specification)|go:"GO:0001843"(neural tube closure)|go:"GO:0001889"(liver development)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0016020"(membrane)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030903"(notochord development)|go:"GO:0033504"(floor plate development)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048565"(digestive tract development)|go:"GO:0048669"(collateral sprouting in absence of injury)|go:"GO:0051639"(actin filament network formation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1990357"(terminal web)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR019025|interpro:IPR039895|mint:O75128|rcsb pdb:4PL8	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/01	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:mkEX2B5sVoK8CD6RWVVCp912otg9606	rigid:dpa9aAlidtikNH4m5YtN9WpK4WA	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P62136	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-357253|uniprotkb:P08129|uniprotkb:P20653|uniprotkb:P22802|uniprotkb:B2R908|intact:EBI-2623163|uniprotkb:Q07161|intact:EBI-2556927|uniprotkb:A6NNR3|ensembl:ENSP00000365936	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:pp1a_human(display_long)|uniprotkb:PPP1CA(gene name)|psi-mi:PPP1CA(display_short)|uniprotkb:PPP1A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745183|imex:IM-28152-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001008709.1|refseq:NP_002699.1|refseq:NP_996756.1|dip:DIP-221N|dip:DIP-38195N|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0051301"(cell division)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|interpro:IPR037979|mint:P62136|rcsb pdb:3E7A|rcsb pdb:3E7B|rcsb pdb:3EGG|rcsb pdb:3EGH|rcsb pdb:3HVQ|rcsb pdb:3N5U|rcsb pdb:3V4Y|rcsb pdb:4G9J|rcsb pdb:4MOV|rcsb pdb:4MOY|rcsb pdb:4MP0|rcsb pdb:4XPN|rcsb pdb:5IOH|rcsb pdb:6ALZ|rcsb pdb:6CZO|rcsb pdb:6DCX|rcsb pdb:6DNO|rcsb pdb:6G0I|rcsb pdb:6G0J|rcsb pdb:6GHM|rcsb pdb:6OBN|rcsb pdb:6OBP|rcsb pdb:6OBQ|rcsb pdb:6OBR|rcsb pdb:6OBS|rcsb pdb:6OBU|rcsb pdb:6ZEE|rcsb pdb:6ZEF|rcsb pdb:6ZEG|rcsb pdb:6ZEH|rcsb pdb:6ZEI|rcsb pdb:6ZEJ|rcsb pdb:6ZK6|reactome:R-HSA-163560|reactome:R-HSA-180024|reactome:R-HSA-2173788|reactome:R-HSA-400253|go:"GO:0098793"(presynapse)|ensembl:ENSG00000172531(gene)|ensembl:ENST00000376745(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0030324"(lung development)	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/01	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:IMypaKng+5AECbCd3N72pgzUlxQ9606	rigid:dpa9aAlidtikNH4m5YtN9WpK4WA	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q86SG5	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-13077820|ensembl:ENSP00000329008|ensembl:ENSP00000357717|ensembl:ENSP00000357718|uniprotkb:D3DV38|uniprotkb:Q5SY69	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:s1a7a_human(display_long)|uniprotkb:S100A7A(gene name)|psi-mi:S100A7A(display_short)|uniprotkb:S100 calcium-binding protein A15(gene name synonym)|uniprotkb:S100 calcium-binding protein A7-like 1(gene name synonym)|uniprotkb:S100 calcium-binding protein A7A(gene name synonym)|uniprotkb:S100A15(gene name synonym)|uniprotkb:S100A7L1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745183|imex:IM-28152-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENSG00000184330(gene)|ensembl:ENST00000329256(transcript)|ensembl:ENST00000368728(transcript)|ensembl:ENST00000368729(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0043621"(protein self-association)|go:"GO:0046914"(transition metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|interpro:IPR028477|interpro:IPR034325|rcsb pdb:4AQI|reactome:R-HSA-6799990|refseq:NP_789793.1	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/01	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:tvDSD+pF9aL+bt9hSvM7o5zpfpE9606	rigid:dpa9aAlidtikNH4m5YtN9WpK4WA	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P06703	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-352877|ensembl:ENSP00000357708|ensembl:ENSP00000357709|ensembl:ENSP00000473589|uniprotkb:Q5RHS4|uniprotkb:D3DV39	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:s10a6_human(display_long)|uniprotkb:S100A6(gene name)|psi-mi:S100A6(display_short)|uniprotkb:CACY(gene name synonym)|uniprotkb:S100 calcium-binding protein A6(gene name synonym)|uniprotkb:Calcyclin(gene name synonym)|uniprotkb:Prolactin receptor-associated protein(gene name synonym)|uniprotkb:Growth factor-inducible protein 2A9(gene name synonym)|uniprotkb:MLN 4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745183|imex:IM-28152-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENSG00000197956(gene)|ensembl:ENST00000368719(transcript)|ensembl:ENST00000368720(transcript)|ensembl:ENST00000496817(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015075"(ion transmembrane transporter activity)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044548"(S100 protein binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|interpro:IPR034118|mint:P06703|rcsb pdb:1K8U|rcsb pdb:1K96|rcsb pdb:1K9K|rcsb pdb:1K9P|rcsb pdb:2M1K|rcsb pdb:4YBH|go:"GO:0062023"(collagen-containing extracellular matrix)|refseq:NP_055439.1|refseq:XP_016857522.1	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/01	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:y8rq2lO1c3DEoVaKnfoLEAHsqmo9606	rigid:dpa9aAlidtikNH4m5YtN9WpK4WA	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P60900	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-357793|uniprotkb:P34062|uniprotkb:Q6IB60|uniprotkb:B2R7J9|uniprotkb:B4DQR4|uniprotkb:B4DXJ9|ensembl:ENSP00000261479	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:psa6_human(display_long)|uniprotkb:PSMA6(gene name)|psi-mi:PSMA6(display_short)|uniprotkb:PROS27(gene name synonym)|uniprotkb:Proteasome iota chain(gene name synonym)|uniprotkb:Macropain iota chain(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex iota chain(gene name synonym)|uniprotkb:27 kDa prosomal protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745183|imex:IM-28152-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_002782.1|refseq:NP_001269162.1|refseq:NP_001269163.1|refseq:XP_016876957.1|refseq:NP_001269161.1|ensembl:ENSG00000100902(gene)|ensembl:ENST00000261479(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0005844"(polysome)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0030016"(myofibril)|go:"GO:0030017"(sarcomere)|go:"GO:0035639"(purine ribonucleoside triphosphate binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR023332|interpro:IPR029055|interpro:IPR034642|mint:P60900|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-29367N	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/01	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:F+Kwr6rnDS3jD53gBGHDIn7HV/89606	rigid:dpa9aAlidtikNH4m5YtN9WpK4WA	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P27361	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-73995|uniprotkb:B0LPG3|uniprotkb:A8CZ58|uniprotkb:Q8NHX1|ensembl:ENSP00000263025	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:mk03_human(display_long)|uniprotkb:ERT2(gene name synonym)|uniprotkb:MAP kinase isoform p44(gene name synonym)|uniprotkb:Microtubule-associated protein 2 kinase(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 1(gene name synonym)|uniprotkb:Insulin-stimulated MAP2 kinase(gene name synonym)|uniprotkb:p44-ERK1(gene name synonym)|uniprotkb:MAPK3(gene name)|psi-mi:MAPK3(display_short)|uniprotkb:ERK1(gene name synonym)|uniprotkb:PRKM3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745183|imex:IM-28152-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001035145.1|refseq:NP_001103361.1|refseq:NP_002737.2|dip:DIP-30985N|ensembl:ENSG00000102882(gene)|ensembl:ENST00000263025(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000657"(negative regulation of apolipoprotein binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P27361|rcsb pdb:2ZOQ|rcsb pdb:4QTB|rcsb pdb:6GES|reactome:R-HSA-110056|reactome:R-HSA-112409|reactome:R-HSA-1169408|reactome:R-HSA-1295596|reactome:R-HSA-162658|reactome:R-HSA-170968|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2029482|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2871796|reactome:R-HSA-3371453|reactome:R-HSA-375165|reactome:R-HSA-444257|reactome:R-HSA-445144|reactome:R-HSA-450341|reactome:R-HSA-456926|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5663213|reactome:R-HSA-5668599|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-6811558|reactome:R-HSA-73728|reactome:R-HSA-74749|reactome:R-HSA-879415|reactome:R-HSA-881907|reactome:R-HSA-8939211|reactome:R-HSA-8940973|reactome:R-HSA-8943724|reactome:R-HSA-9627069|reactome:R-HSA-9634638|reactome:R-HSA-9635465|reactome:R-HSA-9649948|reactome:R-HSA-9652169|reactome:R-HSA-9656223|reactome:R-HSA-9664422|reactome:R-HSA-982772|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/01	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:PGxmRMz0kOsJTfdn21FBiF33YwI9606	rigid:dpa9aAlidtikNH4m5YtN9WpK4WA	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P55265	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-2462104|uniprotkb:B1AQR0|uniprotkb:O15223|uniprotkb:O43859|uniprotkb:O43860|uniprotkb:Q9BYM3|uniprotkb:Q9BYM4|uniprotkb:B1AQQ9|uniprotkb:D3DV76|ensembl:ENSP00000357459	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:dsrad_human(display_long)|uniprotkb:ADAR(gene name)|psi-mi:ADAR(display_short)|uniprotkb:ADAR1(gene name synonym)|uniprotkb:DSRAD(gene name synonym)|uniprotkb:G1P1(gene name synonym)|uniprotkb:IFI4(gene name synonym)|uniprotkb:136 kDa double-stranded RNA-binding protein(gene name synonym)|uniprotkb:K88DSRBP(gene name synonym)|uniprotkb:Interferon-inducible protein 4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745183|imex:IM-28152-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001020278.1|refseq:NP_001102.2|refseq:NP_001180424.1|refseq:NP_056655.2|refseq:NP_056656.2|refseq:XP_006711174.1|refseq:XP_006711175.1|refseq:XP_006711176.1|dip:DIP-29310N|ensembl:ENSG00000160710(gene)|ensembl:ENST00000368474(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002566"(somatic diversification of immune receptors via somatic mutation)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003726"(double-stranded RNA adenosine deaminase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006382"(adenosine to inosine editing)|go:"GO:0006396"(RNA processing)|go:"GO:0006397"(mRNA processing)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0008251"(tRNA-specific adenosine deaminase activity)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0016553"(base conversion or substitution editing)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0035455"(response to interferon-alpha)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044387"(negative regulation of protein kinase activity by regulation of protein phosphorylation)|go:"GO:0044530"(supraspliceosomal complex)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1900369"(negative regulation of RNA interference)|interpro:IPR002466(Adenosine deaminase/editase)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR036388|interpro:IPR036390|interpro:IPR042371|interpro:IPR044456|interpro:IPR044457|mint:P55265|rcsb pdb:1QBJ|rcsb pdb:1QGP|rcsb pdb:1XMK|rcsb pdb:2ACJ|rcsb pdb:2GXB|rcsb pdb:2L54|rcsb pdb:2MDR|rcsb pdb:3F21|rcsb pdb:3F22|rcsb pdb:3F23|rcsb pdb:3IRQ|rcsb pdb:3IRR|rcsb pdb:5ZU1|rcsb pdb:5ZUO|rcsb pdb:5ZUP|rcsb pdb:7C0I|reactome:R-HSA-75102|reactome:R-HSA-77042|reactome:R-HSA-909733|go:"GO:0051607"(defense response to virus)	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/01	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:rP/Yr/h8WLSFNdIuqWnYtZjZ9qI9606	rigid:dpa9aAlidtikNH4m5YtN9WpK4WA	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:O75937	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-1045911|uniprotkb:Q6IBA4|uniprotkb:Q8N4Z5|uniprotkb:Q9P051|uniprotkb:Q9P067|uniprotkb:D3DPM0|uniprotkb:B4DUU4|intact:EBI-28966785|ensembl:ENSP00000263697|ensembl:ENSP00000494062	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:dnjc8_human(display_long)|uniprotkb:Splicing protein spf31(gene name synonym)|uniprotkb:DNAJC8(gene name)|psi-mi:DNAJC8(display_short)|uniprotkb:SPF31(gene name synonym)|uniprotkb:HSPC315(orf name)|uniprotkb:HSPC331(orf name)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745183|imex:IM-28152-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENSP00000263697|ensembl:ENSP00000494062|ensembl:ENSG00000126698(gene)|ensembl:ENSG00000285317(gene)|ensembl:ENST00000263697(transcript)|ensembl:ENST00000645856(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0045171"(intercellular bridge)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR036869|interpro:IPR042858|mint:O75937|reactome:R-HSA-72163|refseq:NP_055095.2	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/01	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:muJkeaOMc4UXHR4DPNuQeciq7PI9606	rigid:dpa9aAlidtikNH4m5YtN9WpK4WA	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:O00244	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-10179267|uniprotkb:Q2M1R6|uniprotkb:A8KAJ8|uniprotkb:D3DQI2|uniprotkb:Q56AP3|ensembl:ENSP00000316854|ensembl:ENSP00000429814|ensembl:ENSP00000430598	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:atox1_human(display_long)|uniprotkb:ATOX1(gene name)|psi-mi:ATOX1(display_short)|uniprotkb:HAH1(gene name synonym)|uniprotkb:Metal transport protein ATX1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745183|imex:IM-28152-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_004036.1|ensembl:ENSG00000177556(gene)|ensembl:ENST00000313115(transcript)|ensembl:ENST00000522710(transcript)|ensembl:ENST00000524142(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0006825"(copper ion transport)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0016530"(metallochaperone activity)|go:"GO:0016531"(copper chaperone activity)|go:"GO:0032767"(copper-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051117"(ATPase binding)|go:"GO:0060003"(copper ion export)|go:"GO:1903136"(cuprous ion binding)|interpro:IPR006121(Heavy metal transport/detoxification protein)|interpro:IPR017969|interpro:IPR036163|rcsb pdb:1FE0|rcsb pdb:1FE4|rcsb pdb:1FEE|rcsb pdb:1TL4|rcsb pdb:1TL5|rcsb pdb:2K1R|rcsb pdb:2LQ9|rcsb pdb:3CJK|rcsb pdb:3IWL|rcsb pdb:3IWX|rcsb pdb:4QOT|rcsb pdb:4YDX|rcsb pdb:4YEA|rcsb pdb:5F0W|rcsb pdb:5T7L|reactome:R-HSA-3299685|reactome:R-HSA-6803544	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/01	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:+aoVGSDXbzrq71ZKogtE9LHtHss9606	rigid:dpa9aAlidtikNH4m5YtN9WpK4WA	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q13144	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-4401110|uniprotkb:Q541Z1|uniprotkb:Q96D04|ensembl:ENSP00000497160	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:ei2be_human(display_long)|uniprotkb:EIF2B5(gene name)|psi-mi:EIF2B5(display_short)|uniprotkb:EIF2BE(gene name synonym)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit epsilon(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745183|imex:IM-28152-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_003898.2|ensembl:ENSG00000145191(gene)|ensembl:ENST00000648915(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0006413"(translational initiation)|go:"GO:0007568"(aging)|go:"GO:0009408"(response to heat)|go:"GO:0009749"(response to glucose)|go:"GO:0010226"(response to lithium ion)|go:"GO:0014002"(astrocyte development)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0021766"(hippocampus development)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042552"(myelination)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR001451(Bacterial transferase hexapeptide repeat)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR011004(Trimeric LpxA-like)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029044|interpro:IPR035543|interpro:IPR044123|rcsb pdb:3JUI|rcsb pdb:6CAJ|rcsb pdb:6EZO|rcsb pdb:6K71|rcsb pdb:6K72|rcsb pdb:6O81|rcsb pdb:6O85|rcsb pdb:6O9Z|rcsb pdb:7D43|rcsb pdb:7D44|rcsb pdb:7D45|rcsb pdb:7D46|rcsb pdb:7L70|rcsb pdb:7L7G|reactome:R-HSA-72731|go:"GO:0005634"(nucleus)	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/01	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:158kR+Yjj/jXya10LiK3Xp0Fa5w9606	rigid:dpa9aAlidtikNH4m5YtN9WpK4WA	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q13838	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-348622|uniprotkb:B0S8C0|uniprotkb:Q5STB8|uniprotkb:O43496|uniprotkb:Q0EFA1|uniprotkb:Q2L6F9|uniprotkb:Q53GL9|uniprotkb:Q5RJ64|uniprotkb:Q5RJ66|uniprotkb:Q5ST94|uniprotkb:Q5STB4|uniprotkb:Q5STB5|uniprotkb:Q5STB7|uniprotkb:Q5STU4|uniprotkb:Q5STU5|uniprotkb:Q5STU6|uniprotkb:Q5STU8|uniprotkb:Q71V76|ensembl:ENSP00000373000|ensembl:ENSP00000379475|ensembl:ENSP00000383151|ensembl:ENSP00000383152|ensembl:ENSP00000387994|ensembl:ENSP00000388880|ensembl:ENSP00000390999|ensembl:ENSP00000391463|ensembl:ENSP00000393712|ensembl:ENSP00000394160|ensembl:ENSP00000398775|ensembl:ENSP00000399030|ensembl:ENSP00000400326|ensembl:ENSP00000404695|ensembl:ENSP00000405560|ensembl:ENSP00000407419|ensembl:ENSP00000411136|ensembl:ENSP00000411853|ensembl:ENSP00000416269	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:dx39b_human(display_long)|uniprotkb:UAP56(gene name synonym)|uniprotkb:DDX39B(gene name)|psi-mi:DDX39B(display_short)|uniprotkb:DEAD box protein UAP56(gene name synonym)|uniprotkb:56 kDa U2AF65-associated protein(gene name synonym)|uniprotkb:ATP-dependent RNA helicase p47(gene name synonym)|uniprotkb:HLA-B-associated transcript 1 protein(gene name synonym)|uniprotkb:BAT1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745183|imex:IM-28152-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_004631.1|refseq:NP_542165.1|ensembl:ENSG00000198563(gene)|ensembl:ENSG00000215425(gene)|ensembl:ENSG00000225073(gene)|ensembl:ENSG00000225859(gene)|ensembl:ENSG00000229496(gene)|ensembl:ENSG00000230624(gene)|ensembl:ENSG00000235439(gene)|ensembl:ENST00000383508(transcript)|ensembl:ENST00000396172(transcript)|ensembl:ENST00000400295(transcript)|ensembl:ENST00000400296(transcript)|ensembl:ENST00000412106(transcript)|ensembl:ENST00000412330(transcript)|ensembl:ENST00000413678(transcript)|ensembl:ENST00000414440(transcript)|ensembl:ENST00000415689(transcript)|ensembl:ENST00000416863(transcript)|ensembl:ENST00000430784(transcript)|ensembl:ENST00000431360(transcript)|ensembl:ENST00000441425(transcript)|ensembl:ENST00000445218(transcript)|ensembl:ENST00000448296(transcript)|ensembl:ENST00000453138(transcript)|ensembl:ENST00000456476(transcript)|ensembl:ENST00000456666(transcript)|ensembl:ENST00000458640(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000346"(transcription export complex)|go:"GO:0001889"(liver development)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005688"(U6 snRNP)|go:"GO:0005737"(cytoplasm)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0008186"(ATP-dependent activity, acting on RNA)|go:"GO:0008380"(RNA splicing)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046784"(viral mRNA export from host cell nucleus)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q13838|rcsb pdb:1T5I|rcsb pdb:1T6N|rcsb pdb:1XTI|rcsb pdb:1XTJ|rcsb pdb:1XTK|rcsb pdb:7APK|reactome:R-HSA-159236|reactome:R-HSA-72187|reactome:R-HSA-73856|reactome:R-HSA-9013418	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/01	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:Cl/rf1oq31fZbLHC2foUXu9MBOE9606	rigid:dpa9aAlidtikNH4m5YtN9WpK4WA	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:Q9H361	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-1055272|uniprotkb:Q8NHV0|uniprotkb:Q9H086|ensembl:ENSP00000281589	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:pabp3_human(display_long)|uniprotkb:"Testis-specific poly(A)-binding protein"(gene name synonym)|uniprotkb:PABPC3(gene name)|psi-mi:PABPC3(display_short)|uniprotkb:PABP3(gene name synonym)|uniprotkb:PABPL3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745183|imex:IM-28152-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_112241.2|ensembl:ENSG00000151846(gene)|ensembl:ENST00000281589(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016071"(mRNA metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR006515(Polyadenylate binding protein, human types 1, 2, 3, 4)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR036053|mint:Q9H361|rcsb pdb:2D9P|rcsb pdb:4IVE	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/01	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:g/tDJDBcBC+s8P6LGDIwgZO8HHY9606	rigid:dpa9aAlidtikNH4m5YtN9WpK4WA	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P49790	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-286779|uniprotkb:Q5T9I7|intact:EBI-1237421|uniprotkb:E7EPX5|uniprotkb:Q4LE47|uniprotkb:Q7Z743|uniprotkb:B4DIK2|uniprotkb:F6QR24|ensembl:ENSP00000262077	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:nu153_human(display_long)|uniprotkb:Nucleoporin Nup153(gene name synonym)|uniprotkb:153 kDa nucleoporin(gene name synonym)|uniprotkb:NUP153(gene name)|psi-mi:NUP153(display_short)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745183|imex:IM-28152-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENSP00000262077|ensembl:ENST00000537253|ensembl:ENSP00000444029|ensembl:ENST00000613258|ensembl:ENSP00000478627|refseq:NP_005115.2|refseq:NP_001265138.1|refseq:NP_001265139.1|dip:DIP-38185N|ensembl:ENSG00000124789(gene)|ensembl:ENST00000262077(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0016020"(membrane)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034399"(nuclear periphery)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042802"(identical protein binding)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0043657"(host cell)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046832"(negative regulation of RNA export from nucleus)|go:"GO:0046872"(metal ion binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR013913(Nucleoporin, Nup153-like)|interpro:IPR018892|interpro:IPR026054|interpro:IPR036443|mint:P49790|rcsb pdb:2EBQ|rcsb pdb:2EBR|rcsb pdb:2EBV|rcsb pdb:2GQE|rcsb pdb:4U0C|rcsb pdb:4U0D|rcsb pdb:5TSV|rcsb pdb:5TSX|rcsb pdb:6AYA|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/01	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:rOax/ikcAu5fmDiCOauVr7Y/fzY9606	rigid:dpa9aAlidtikNH4m5YtN9WpK4WA	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P31942	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-711437|uniprotkb:Q9NPI4|uniprotkb:Q9UFU4|uniprotkb:Q9Y4J5|uniprotkb:Q9BSX1|uniprotkb:Q9NP53|uniprotkb:Q9NP96|uniprotkb:Q9NPA7|ensembl:ENSP00000265866|uniprotkb:A8K682|uniprotkb:B3KRE1	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:hnrh3_human(display_long)|uniprotkb:HNRNPH3(gene name)|psi-mi:HNRNPH3(display_short)|uniprotkb:HNRPH3(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein 2H9(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745183|imex:IM-28152-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENSG00000096746(gene)|ensembl:ENST00000265866(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034969|interpro:IPR034970|interpro:IPR035979|mint:P31942|refseq:NP_036339.1|refseq:NP_067676.2|refseq:NP_001309363.1|refseq:NP_001309365.1|refseq:NP_001309366.1|refseq:NP_001309367.1|refseq:NP_001309368.1|refseq:NP_001309369.1|refseq:NP_001309370.1|refseq:NP_001309374.1|refseq:NP_001309375.1|refseq:NP_001309376.1|refseq:NP_001309377.1|refseq:NP_001309378.1|refseq:XP_016871657.1|refseq:XP_016871658.1	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/01	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:iJGBIhPXnQIIFQmgxWB1WjwVXSY9606	rigid:dpa9aAlidtikNH4m5YtN9WpK4WA	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P55795	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-352823|ensembl:ENSP00000361927|uniprotkb:Q9HHA7|uniprotkb:A1L400	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:hnrh2_human(display_long)|uniprotkb:HNRNPH2(gene name)|psi-mi:HNRNPH2(display_short)|uniprotkb:FTP3(gene name synonym)|uniprotkb:HNRPH2(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein H'(gene name synonym)|uniprotkb:FTP-3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745183|imex:IM-28152-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENSG00000126945(gene)|ensembl:ENST00000316594(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012996(Zinc finger, CHHC-type)|interpro:IPR035979|mint:P55795|rcsb pdb:1WEZ|rcsb pdb:1WG5|rcsb pdb:6DG1|reactome:R-HSA-72163|reactome:R-HSA-72203|interpro:IPR000504(RNA recognition motif, RNP-1)|refseq:NP_001027565.1|refseq:NP_062543.1	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/01	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:811j5syFsbk/QSaZv/ag9QsFUEQ9606	rigid:dpa9aAlidtikNH4m5YtN9WpK4WA	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P83105	uniprotkb:P55211	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-516799|uniprotkb:O95348|uniprotkb:Q92852|uniprotkb:Q9BQ62|uniprotkb:Q9UEQ3|uniprotkb:Q9UIJ8|uniprotkb:Q53Y70|uniprotkb:Q5JRU9|uniprotkb:Q5UGI1|uniprotkb:B4E1A3|ensembl:ENSP00000330237	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:casp9_human(display_long)|uniprotkb:ICE-like apoptotic protease 6(gene name synonym)|uniprotkb:Apoptotic protease Mch-6(gene name synonym)|uniprotkb:Apoptotic protease-activating factor 3(gene name synonym)|uniprotkb:CASP9(gene name)|psi-mi:CASP9(display_short)|uniprotkb:MCH6(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745328|imex:IM-28152-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001264983.1|refseq:NP_001220.2|refseq:NP_127463.2|refseq:XP_005246071.1|dip:DIP-27625N|ensembl:ENSG00000132906(gene)|ensembl:ENST00000333868(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002931"(response to ischemia)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007568"(aging)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008233"(peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030220"(platelet formation)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043293"(apoptosome)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033171|interpro:IPR042147|mint:P55211|rcsb pdb:1JXQ|rcsb pdb:1NW9|rcsb pdb:2AR9|rcsb pdb:3D9T|rcsb pdb:3V3K|rcsb pdb:3YGS|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|rcsb pdb:5WVE|reactome:R-HSA-111458|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-168638|reactome:R-HSA-198323|reactome:R-HSA-418889|reactome:R-HSA-5674400|reactome:R-HSA-9627069	-	-	-	figure legend:Figure 1A|comment:"Other molecules were detected but cannot be identified, notably: beta-tubulin and Actin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/01	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:IYW59Vh17AEnXa6/wLpkIPNE0Bo9606	rigid:F0j1jBJMdH7zZfUtyMpb8jw8NtM	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P83105	uniprotkb:P55210	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-523958|uniprotkb:B5BU45|uniprotkb:Q5SVL3|uniprotkb:Q13364|uniprotkb:Q96BA0|uniprotkb:Q5SVL0|uniprotkb:Q53YD5|ensembl:ENSP00000298701|ensembl:ENSP00000358321|ensembl:ENSP00000358324|ensembl:ENSP00000480584|uniprotkb:D3DRB8|uniprotkb:B4DQU7	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:casp7_human(display_long)|uniprotkb:ICE-like apoptotic protease 3(gene name synonym)|uniprotkb:Apoptotic protease Mch-3(gene name synonym)|uniprotkb:CMH-1(gene name synonym)|uniprotkb:CASP7(gene name)|psi-mi:CASP7(display_short)|uniprotkb:MCH3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745328|imex:IM-28152-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001218.1|refseq:NP_203124.1|refseq:NP_203125.1|refseq:NP_203126.1|ensembl:ENSG00000165806(gene)|ensembl:ENST00000345633(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|ensembl:ENST00000369315(transcript)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0016485"(protein processing)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0072734"(cellular response to staurosporine)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR015471(Caspase-7)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|mint:P55210|rcsb pdb:1F1J|ensembl:ENST00000369318(transcript)|rcsb pdb:1GQF|ensembl:ENST00000621345(transcript)|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1K86|rcsb pdb:1K88|rcsb pdb:1KMC|rcsb pdb:1MIA|rcsb pdb:1SHJ|go:"GO:0004190"(aspartic-type endopeptidase activity)|rcsb pdb:1SHL|rcsb pdb:2QL5|go:"GO:0004197"(cysteine-type endopeptidase activity)|rcsb pdb:2QL7|go:"GO:0005634"(nucleus)|rcsb pdb:2QL9|rcsb pdb:2QLB|rcsb pdb:2QLF|rcsb pdb:2QLJ|rcsb pdb:3EDR|go:"GO:0005654"(nucleoplasm)|rcsb pdb:3H1P|rcsb pdb:3IBC|rcsb pdb:3IBF|rcsb pdb:3R5K|rcsb pdb:4FDL|rcsb pdb:4FEA|rcsb pdb:4HQ0|rcsb pdb:4HQR|rcsb pdb:4JB8|reactome:R-HSA-111464|reactome:R-HSA-111465|reactome:R-HSA-111469|reactome:R-HSA-264870|rcsb pdb:4JJ8|rcsb pdb:4JR1|rcsb pdb:4JR2|rcsb pdb:4LSZ|rcsb pdb:4ZVO|rcsb pdb:4ZVP|rcsb pdb:4ZVQ|rcsb pdb:4ZVR|rcsb pdb:4ZVS|rcsb pdb:4ZVT|rcsb pdb:4ZVU|rcsb pdb:5IC6|rcsb pdb:5K20|rcsb pdb:5V6U|rcsb pdb:5V6Z|reactome:R-HSA-111459|reactome:R-HSA-111463|refseq:NP_001253986.1|refseq:NP_001253987.1|refseq:NP_001253985.1|refseq:NP_001307840.1|dip:DIP-29973N	-	-	-	figure legend:Figure 1A|comment:"Other molecules were detected but cannot be identified, notably: beta-tubulin and Actin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/01	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:XcSWtfWWnuOKIbAR+TXpkCq5fig9606	rigid:F0j1jBJMdH7zZfUtyMpb8jw8NtM	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P83105	uniprotkb:P98170	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-517127|uniprotkb:Q9NQ14|uniprotkb:D3DTF2|ensembl:ENSP00000347858|ensembl:ENSP00000360242|ensembl:ENSP00000395230	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:xiap_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 3(gene name synonym)|uniprotkb:X-linked inhibitor of apoptosis protein(gene name synonym)|uniprotkb:IAP-like protein(gene name synonym)|uniprotkb:XIAP(gene name)|psi-mi:XIAP(display_short)|uniprotkb:API3(gene name synonym)|uniprotkb:IAP3(gene name synonym)|uniprotkb:BIRC4(gene name synonym)|uniprotkb:Baculoviral IAP repeat-containing protein 4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase XIAP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745328|imex:IM-28152-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:XP_006724817.1|refseq:NP_001158.2|refseq:NP_001191330.1|refseq:XP_011529631.1|dip:DIP-27626N|ensembl:ENSG00000101966(gene)|ensembl:ENST00000355640(transcript)|ensembl:ENST00000371199(transcript)|ensembl:ENST00000434753(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055070"(copper ion homeostasis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR042579|mint:P98170|rcsb pdb:1C9Q|rcsb pdb:1F9X|rcsb pdb:1G3F|rcsb pdb:1G73|rcsb pdb:1I3O|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1KMC|rcsb pdb:1NW9|rcsb pdb:1TFQ|rcsb pdb:1TFT|rcsb pdb:2ECG|rcsb pdb:2JK7|rcsb pdb:2KNA|rcsb pdb:2OPY|rcsb pdb:2OPZ|rcsb pdb:2POI|rcsb pdb:2POP|rcsb pdb:2QRA|rcsb pdb:2VSL|rcsb pdb:3CLX|rcsb pdb:3CM2|rcsb pdb:3CM7|rcsb pdb:3EYL|rcsb pdb:3G76|rcsb pdb:3HL5|rcsb pdb:3UW4|rcsb pdb:3UW5|rcsb pdb:4EC4|rcsb pdb:4HY0|rcsb pdb:4IC2|rcsb pdb:4IC3|rcsb pdb:4J3Y|rcsb pdb:4J44|rcsb pdb:4J45|rcsb pdb:4J46|rcsb pdb:4J47|rcsb pdb:4J48|rcsb pdb:4KJU|rcsb pdb:4KJV|rcsb pdb:4KMP|rcsb pdb:4MTZ|rcsb pdb:4OXC|rcsb pdb:4WVS|rcsb pdb:4WVT|rcsb pdb:4WVU|rcsb pdb:5C0K|rcsb pdb:5C0L|rcsb pdb:5C3H|rcsb pdb:5C3K|rcsb pdb:5C7A|rcsb pdb:5C7B|rcsb pdb:5C7C|rcsb pdb:5C7D|rcsb pdb:5C83|rcsb pdb:5C84|rcsb pdb:5M6E|rcsb pdb:5M6F|rcsb pdb:5M6H|rcsb pdb:5M6L|rcsb pdb:5M6M|rcsb pdb:5O6T|rcsb pdb:5OQW|rcsb pdb:6EY2|rcsb pdb:6GJW|rcsb pdb:6QCI|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-111469|reactome:R-HSA-3769402|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-9627069	-	-	-	figure legend:Figure 1A|comment:"Other molecules were detected but cannot be identified, notably: beta-tubulin and Actin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/01	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:6eDcOay+c2ZmIAD/pwnCDROBwgM9606	rigid:F0j1jBJMdH7zZfUtyMpb8jw8NtM	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P83105	uniprotkb:P06703	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-352877|ensembl:ENSP00000357708|ensembl:ENSP00000357709|ensembl:ENSP00000473589|uniprotkb:Q5RHS4|uniprotkb:D3DV39	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:s10a6_human(display_long)|uniprotkb:S100A6(gene name)|psi-mi:S100A6(display_short)|uniprotkb:CACY(gene name synonym)|uniprotkb:S100 calcium-binding protein A6(gene name synonym)|uniprotkb:Calcyclin(gene name synonym)|uniprotkb:Prolactin receptor-associated protein(gene name synonym)|uniprotkb:Growth factor-inducible protein 2A9(gene name synonym)|uniprotkb:MLN 4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745328|imex:IM-28152-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENSG00000197956(gene)|ensembl:ENST00000368719(transcript)|ensembl:ENST00000368720(transcript)|ensembl:ENST00000496817(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015075"(ion transmembrane transporter activity)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044548"(S100 protein binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|interpro:IPR034118|mint:P06703|rcsb pdb:1K8U|rcsb pdb:1K96|rcsb pdb:1K9K|rcsb pdb:1K9P|rcsb pdb:2M1K|rcsb pdb:4YBH|go:"GO:0062023"(collagen-containing extracellular matrix)|refseq:NP_055439.1|refseq:XP_016857522.1	-	-	-	figure legend:Figure 1A|comment:"Other molecules were detected but cannot be identified, notably: beta-tubulin and Actin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/01	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:y8rq2lO1c3DEoVaKnfoLEAHsqmo9606	rigid:F0j1jBJMdH7zZfUtyMpb8jw8NtM	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P83105	uniprotkb:P17987	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-356553|uniprotkb:Q15556|uniprotkb:Q5TCM3|uniprotkb:E1P5B2|ensembl:ENSP00000317334	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:tcpa_human(display_long)|uniprotkb:CCTA(gene name synonym)|uniprotkb:TCP1(gene name)|psi-mi:TCP1(display_short)|uniprotkb:CCT1(gene name synonym)|uniprotkb:CCT-alpha(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745328|imex:IM-28152-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_110379.2|ensembl:ENSG00000120438(gene)|ensembl:ENST00000321394(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000792"(heterochromatin)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:2000109"(regulation of macrophage apoptotic process)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044053"(translocation of peptides or proteins into host cell cytoplasm)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|interpro:IPR012715(T-complex protein 1, alpha subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|reactome:R-HSA-8950505|interpro:IPR027413|mint:P17987|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|dip:DIP-33676N	-	-	-	figure legend:Figure 1A|comment:"Other molecules were detected but cannot be identified, notably: beta-tubulin and Actin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/01	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:CYJ5rPjKOH3sAP+j0ckdHHu81g49606	rigid:F0j1jBJMdH7zZfUtyMpb8jw8NtM	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P83105	uniprotkb:P55211	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-516799|uniprotkb:O95348|uniprotkb:Q92852|uniprotkb:Q9BQ62|uniprotkb:Q9UEQ3|uniprotkb:Q9UIJ8|uniprotkb:Q53Y70|uniprotkb:Q5JRU9|uniprotkb:Q5UGI1|uniprotkb:B4E1A3|ensembl:ENSP00000330237	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:casp9_human(display_long)|uniprotkb:ICE-like apoptotic protease 6(gene name synonym)|uniprotkb:Apoptotic protease Mch-6(gene name synonym)|uniprotkb:Apoptotic protease-activating factor 3(gene name synonym)|uniprotkb:CASP9(gene name)|psi-mi:CASP9(display_short)|uniprotkb:MCH6(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745341|imex:IM-28152-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001264983.1|refseq:NP_001220.2|refseq:NP_127463.2|refseq:XP_005246071.1|dip:DIP-27625N|ensembl:ENSG00000132906(gene)|ensembl:ENST00000333868(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002931"(response to ischemia)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007568"(aging)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008233"(peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030220"(platelet formation)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043293"(apoptosome)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033171|interpro:IPR042147|mint:P55211|rcsb pdb:1JXQ|rcsb pdb:1NW9|rcsb pdb:2AR9|rcsb pdb:3D9T|rcsb pdb:3V3K|rcsb pdb:3YGS|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|rcsb pdb:5WVE|reactome:R-HSA-111458|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-168638|reactome:R-HSA-198323|reactome:R-HSA-418889|reactome:R-HSA-5674400|reactome:R-HSA-9627069	-	-	-	figure legend:Figure 1B|comment:"Other molecules were detected but cannot be identified, notably: beta-tubulin and Actin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/01	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:IYW59Vh17AEnXa6/wLpkIPNE0Bo9606	rigid:F0j1jBJMdH7zZfUtyMpb8jw8NtM	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P83105	uniprotkb:P55210	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-523958|uniprotkb:B5BU45|uniprotkb:Q5SVL3|uniprotkb:Q13364|uniprotkb:Q96BA0|uniprotkb:Q5SVL0|uniprotkb:Q53YD5|ensembl:ENSP00000298701|ensembl:ENSP00000358321|ensembl:ENSP00000358324|ensembl:ENSP00000480584|uniprotkb:D3DRB8|uniprotkb:B4DQU7	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:casp7_human(display_long)|uniprotkb:ICE-like apoptotic protease 3(gene name synonym)|uniprotkb:Apoptotic protease Mch-3(gene name synonym)|uniprotkb:CMH-1(gene name synonym)|uniprotkb:CASP7(gene name)|psi-mi:CASP7(display_short)|uniprotkb:MCH3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745341|imex:IM-28152-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001218.1|refseq:NP_203124.1|refseq:NP_203125.1|refseq:NP_203126.1|ensembl:ENSG00000165806(gene)|ensembl:ENST00000345633(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|ensembl:ENST00000369315(transcript)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0016485"(protein processing)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0072734"(cellular response to staurosporine)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR015471(Caspase-7)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|mint:P55210|rcsb pdb:1F1J|ensembl:ENST00000369318(transcript)|rcsb pdb:1GQF|ensembl:ENST00000621345(transcript)|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1K86|rcsb pdb:1K88|rcsb pdb:1KMC|rcsb pdb:1MIA|rcsb pdb:1SHJ|go:"GO:0004190"(aspartic-type endopeptidase activity)|rcsb pdb:1SHL|rcsb pdb:2QL5|go:"GO:0004197"(cysteine-type endopeptidase activity)|rcsb pdb:2QL7|go:"GO:0005634"(nucleus)|rcsb pdb:2QL9|rcsb pdb:2QLB|rcsb pdb:2QLF|rcsb pdb:2QLJ|rcsb pdb:3EDR|go:"GO:0005654"(nucleoplasm)|rcsb pdb:3H1P|rcsb pdb:3IBC|rcsb pdb:3IBF|rcsb pdb:3R5K|rcsb pdb:4FDL|rcsb pdb:4FEA|rcsb pdb:4HQ0|rcsb pdb:4HQR|rcsb pdb:4JB8|reactome:R-HSA-111464|reactome:R-HSA-111465|reactome:R-HSA-111469|reactome:R-HSA-264870|rcsb pdb:4JJ8|rcsb pdb:4JR1|rcsb pdb:4JR2|rcsb pdb:4LSZ|rcsb pdb:4ZVO|rcsb pdb:4ZVP|rcsb pdb:4ZVQ|rcsb pdb:4ZVR|rcsb pdb:4ZVS|rcsb pdb:4ZVT|rcsb pdb:4ZVU|rcsb pdb:5IC6|rcsb pdb:5K20|rcsb pdb:5V6U|rcsb pdb:5V6Z|reactome:R-HSA-111459|reactome:R-HSA-111463|refseq:NP_001253986.1|refseq:NP_001253987.1|refseq:NP_001253985.1|refseq:NP_001307840.1|dip:DIP-29973N	-	-	-	figure legend:Figure 1B|comment:"Other molecules were detected but cannot be identified, notably: beta-tubulin and Actin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/01	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:XcSWtfWWnuOKIbAR+TXpkCq5fig9606	rigid:F0j1jBJMdH7zZfUtyMpb8jw8NtM	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P83105	uniprotkb:P98170	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-517127|uniprotkb:Q9NQ14|uniprotkb:D3DTF2|ensembl:ENSP00000347858|ensembl:ENSP00000360242|ensembl:ENSP00000395230	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:xiap_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 3(gene name synonym)|uniprotkb:X-linked inhibitor of apoptosis protein(gene name synonym)|uniprotkb:IAP-like protein(gene name synonym)|uniprotkb:XIAP(gene name)|psi-mi:XIAP(display_short)|uniprotkb:API3(gene name synonym)|uniprotkb:IAP3(gene name synonym)|uniprotkb:BIRC4(gene name synonym)|uniprotkb:Baculoviral IAP repeat-containing protein 4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase XIAP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745341|imex:IM-28152-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:XP_006724817.1|refseq:NP_001158.2|refseq:NP_001191330.1|refseq:XP_011529631.1|dip:DIP-27626N|ensembl:ENSG00000101966(gene)|ensembl:ENST00000355640(transcript)|ensembl:ENST00000371199(transcript)|ensembl:ENST00000434753(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055070"(copper ion homeostasis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR042579|mint:P98170|rcsb pdb:1C9Q|rcsb pdb:1F9X|rcsb pdb:1G3F|rcsb pdb:1G73|rcsb pdb:1I3O|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1KMC|rcsb pdb:1NW9|rcsb pdb:1TFQ|rcsb pdb:1TFT|rcsb pdb:2ECG|rcsb pdb:2JK7|rcsb pdb:2KNA|rcsb pdb:2OPY|rcsb pdb:2OPZ|rcsb pdb:2POI|rcsb pdb:2POP|rcsb pdb:2QRA|rcsb pdb:2VSL|rcsb pdb:3CLX|rcsb pdb:3CM2|rcsb pdb:3CM7|rcsb pdb:3EYL|rcsb pdb:3G76|rcsb pdb:3HL5|rcsb pdb:3UW4|rcsb pdb:3UW5|rcsb pdb:4EC4|rcsb pdb:4HY0|rcsb pdb:4IC2|rcsb pdb:4IC3|rcsb pdb:4J3Y|rcsb pdb:4J44|rcsb pdb:4J45|rcsb pdb:4J46|rcsb pdb:4J47|rcsb pdb:4J48|rcsb pdb:4KJU|rcsb pdb:4KJV|rcsb pdb:4KMP|rcsb pdb:4MTZ|rcsb pdb:4OXC|rcsb pdb:4WVS|rcsb pdb:4WVT|rcsb pdb:4WVU|rcsb pdb:5C0K|rcsb pdb:5C0L|rcsb pdb:5C3H|rcsb pdb:5C3K|rcsb pdb:5C7A|rcsb pdb:5C7B|rcsb pdb:5C7C|rcsb pdb:5C7D|rcsb pdb:5C83|rcsb pdb:5C84|rcsb pdb:5M6E|rcsb pdb:5M6F|rcsb pdb:5M6H|rcsb pdb:5M6L|rcsb pdb:5M6M|rcsb pdb:5O6T|rcsb pdb:5OQW|rcsb pdb:6EY2|rcsb pdb:6GJW|rcsb pdb:6QCI|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-111469|reactome:R-HSA-3769402|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-9627069	-	-	-	figure legend:Figure 1B|comment:"Other molecules were detected but cannot be identified, notably: beta-tubulin and Actin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/01	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:6eDcOay+c2ZmIAD/pwnCDROBwgM9606	rigid:F0j1jBJMdH7zZfUtyMpb8jw8NtM	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P83105	uniprotkb:P06703	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-352877|ensembl:ENSP00000357708|ensembl:ENSP00000357709|ensembl:ENSP00000473589|uniprotkb:Q5RHS4|uniprotkb:D3DV39	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:s10a6_human(display_long)|uniprotkb:S100A6(gene name)|psi-mi:S100A6(display_short)|uniprotkb:CACY(gene name synonym)|uniprotkb:S100 calcium-binding protein A6(gene name synonym)|uniprotkb:Calcyclin(gene name synonym)|uniprotkb:Prolactin receptor-associated protein(gene name synonym)|uniprotkb:Growth factor-inducible protein 2A9(gene name synonym)|uniprotkb:MLN 4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745341|imex:IM-28152-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENSG00000197956(gene)|ensembl:ENST00000368719(transcript)|ensembl:ENST00000368720(transcript)|ensembl:ENST00000496817(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015075"(ion transmembrane transporter activity)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044548"(S100 protein binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|interpro:IPR034118|mint:P06703|rcsb pdb:1K8U|rcsb pdb:1K96|rcsb pdb:1K9K|rcsb pdb:1K9P|rcsb pdb:2M1K|rcsb pdb:4YBH|go:"GO:0062023"(collagen-containing extracellular matrix)|refseq:NP_055439.1|refseq:XP_016857522.1	-	-	-	figure legend:Figure 1B|comment:"Other molecules were detected but cannot be identified, notably: beta-tubulin and Actin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/01	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:y8rq2lO1c3DEoVaKnfoLEAHsqmo9606	rigid:F0j1jBJMdH7zZfUtyMpb8jw8NtM	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P83105	uniprotkb:P17987	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-356553|uniprotkb:Q15556|uniprotkb:Q5TCM3|uniprotkb:E1P5B2|ensembl:ENSP00000317334	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:tcpa_human(display_long)|uniprotkb:CCTA(gene name synonym)|uniprotkb:TCP1(gene name)|psi-mi:TCP1(display_short)|uniprotkb:CCT1(gene name synonym)|uniprotkb:CCT-alpha(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745341|imex:IM-28152-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_110379.2|ensembl:ENSG00000120438(gene)|ensembl:ENST00000321394(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000792"(heterochromatin)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:2000109"(regulation of macrophage apoptotic process)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044053"(translocation of peptides or proteins into host cell cytoplasm)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|interpro:IPR012715(T-complex protein 1, alpha subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|reactome:R-HSA-8950505|interpro:IPR027413|mint:P17987|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|dip:DIP-33676N	-	-	-	figure legend:Figure 1B|comment:"Other molecules were detected but cannot be identified, notably: beta-tubulin and Actin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/01	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:CYJ5rPjKOH3sAP+j0ckdHHu81g49606	rigid:F0j1jBJMdH7zZfUtyMpb8jw8NtM	false	sufficient binding region:147-476|his tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P98170	uniprotkb:P83105	intact:EBI-517127|uniprotkb:Q9NQ14|uniprotkb:D3DTF2|ensembl:ENSP00000347858|ensembl:ENSP00000360242|ensembl:ENSP00000395230	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	psi-mi:xiap_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 3(gene name synonym)|uniprotkb:X-linked inhibitor of apoptosis protein(gene name synonym)|uniprotkb:IAP-like protein(gene name synonym)|uniprotkb:XIAP(gene name)|psi-mi:XIAP(display_short)|uniprotkb:API3(gene name synonym)|uniprotkb:IAP3(gene name synonym)|uniprotkb:BIRC4(gene name synonym)|uniprotkb:Baculoviral IAP repeat-containing protein 4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase XIAP(gene name synonym)	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745354|imex:IM-28152-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006724817.1|refseq:NP_001158.2|refseq:NP_001191330.1|refseq:XP_011529631.1|dip:DIP-27626N|ensembl:ENSG00000101966(gene)|ensembl:ENST00000355640(transcript)|ensembl:ENST00000371199(transcript)|ensembl:ENST00000434753(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055070"(copper ion homeostasis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR042579|mint:P98170|rcsb pdb:1C9Q|rcsb pdb:1F9X|rcsb pdb:1G3F|rcsb pdb:1G73|rcsb pdb:1I3O|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1KMC|rcsb pdb:1NW9|rcsb pdb:1TFQ|rcsb pdb:1TFT|rcsb pdb:2ECG|rcsb pdb:2JK7|rcsb pdb:2KNA|rcsb pdb:2OPY|rcsb pdb:2OPZ|rcsb pdb:2POI|rcsb pdb:2POP|rcsb pdb:2QRA|rcsb pdb:2VSL|rcsb pdb:3CLX|rcsb pdb:3CM2|rcsb pdb:3CM7|rcsb pdb:3EYL|rcsb pdb:3G76|rcsb pdb:3HL5|rcsb pdb:3UW4|rcsb pdb:3UW5|rcsb pdb:4EC4|rcsb pdb:4HY0|rcsb pdb:4IC2|rcsb pdb:4IC3|rcsb pdb:4J3Y|rcsb pdb:4J44|rcsb pdb:4J45|rcsb pdb:4J46|rcsb pdb:4J47|rcsb pdb:4J48|rcsb pdb:4KJU|rcsb pdb:4KJV|rcsb pdb:4KMP|rcsb pdb:4MTZ|rcsb pdb:4OXC|rcsb pdb:4WVS|rcsb pdb:4WVT|rcsb pdb:4WVU|rcsb pdb:5C0K|rcsb pdb:5C0L|rcsb pdb:5C3H|rcsb pdb:5C3K|rcsb pdb:5C7A|rcsb pdb:5C7B|rcsb pdb:5C7C|rcsb pdb:5C7D|rcsb pdb:5C83|rcsb pdb:5C84|rcsb pdb:5M6E|rcsb pdb:5M6F|rcsb pdb:5M6H|rcsb pdb:5M6L|rcsb pdb:5M6M|rcsb pdb:5O6T|rcsb pdb:5OQW|rcsb pdb:6EY2|rcsb pdb:6GJW|rcsb pdb:6QCI|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-111469|reactome:R-HSA-3769402|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-9627069	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	-	-	-	figure legend:Figure 2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/01	rogid:6eDcOay+c2ZmIAD/pwnCDROBwgM9606	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rigid:3b25XRC17oFKztpV8xz6mmTQVE8	false	his tag:c-c	sufficient binding region:147-476|his tag:c-c	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P17987	uniprotkb:P83105	intact:EBI-356553|uniprotkb:Q15556|uniprotkb:Q5TCM3|uniprotkb:E1P5B2|ensembl:ENSP00000317334	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	psi-mi:tcpa_human(display_long)|uniprotkb:CCTA(gene name synonym)|uniprotkb:TCP1(gene name)|psi-mi:TCP1(display_short)|uniprotkb:CCT1(gene name synonym)|uniprotkb:CCT-alpha(gene name synonym)	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745367|imex:IM-28152-41	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_110379.2|ensembl:ENSG00000120438(gene)|ensembl:ENST00000321394(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000792"(heterochromatin)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:2000109"(regulation of macrophage apoptotic process)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044053"(translocation of peptides or proteins into host cell cytoplasm)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|interpro:IPR012715(T-complex protein 1, alpha subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|reactome:R-HSA-8950505|interpro:IPR027413|mint:P17987|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|dip:DIP-33676N	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	-	-	-	figure legend:Figure 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/01	rogid:CYJ5rPjKOH3sAP+j0ckdHHu81g49606	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rigid:LGtFAQWNOgC42vqR/J4mkxZE4mM	false	his tag:c-c	sufficient binding region:147-476|his tag:c-c	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P98170	uniprotkb:P83105	intact:EBI-517127|uniprotkb:Q9NQ14|uniprotkb:D3DTF2|ensembl:ENSP00000347858|ensembl:ENSP00000360242|ensembl:ENSP00000395230	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	psi-mi:xiap_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 3(gene name synonym)|uniprotkb:X-linked inhibitor of apoptosis protein(gene name synonym)|uniprotkb:IAP-like protein(gene name synonym)|uniprotkb:XIAP(gene name)|psi-mi:XIAP(display_short)|uniprotkb:API3(gene name synonym)|uniprotkb:IAP3(gene name synonym)|uniprotkb:BIRC4(gene name synonym)|uniprotkb:Baculoviral IAP repeat-containing protein 4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase XIAP(gene name synonym)	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745410|imex:IM-28152-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006724817.1|refseq:NP_001158.2|refseq:NP_001191330.1|refseq:XP_011529631.1|dip:DIP-27626N|ensembl:ENSG00000101966(gene)|ensembl:ENST00000355640(transcript)|ensembl:ENST00000371199(transcript)|ensembl:ENST00000434753(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055070"(copper ion homeostasis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR042579|mint:P98170|rcsb pdb:1C9Q|rcsb pdb:1F9X|rcsb pdb:1G3F|rcsb pdb:1G73|rcsb pdb:1I3O|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1KMC|rcsb pdb:1NW9|rcsb pdb:1TFQ|rcsb pdb:1TFT|rcsb pdb:2ECG|rcsb pdb:2JK7|rcsb pdb:2KNA|rcsb pdb:2OPY|rcsb pdb:2OPZ|rcsb pdb:2POI|rcsb pdb:2POP|rcsb pdb:2QRA|rcsb pdb:2VSL|rcsb pdb:3CLX|rcsb pdb:3CM2|rcsb pdb:3CM7|rcsb pdb:3EYL|rcsb pdb:3G76|rcsb pdb:3HL5|rcsb pdb:3UW4|rcsb pdb:3UW5|rcsb pdb:4EC4|rcsb pdb:4HY0|rcsb pdb:4IC2|rcsb pdb:4IC3|rcsb pdb:4J3Y|rcsb pdb:4J44|rcsb pdb:4J45|rcsb pdb:4J46|rcsb pdb:4J47|rcsb pdb:4J48|rcsb pdb:4KJU|rcsb pdb:4KJV|rcsb pdb:4KMP|rcsb pdb:4MTZ|rcsb pdb:4OXC|rcsb pdb:4WVS|rcsb pdb:4WVT|rcsb pdb:4WVU|rcsb pdb:5C0K|rcsb pdb:5C0L|rcsb pdb:5C3H|rcsb pdb:5C3K|rcsb pdb:5C7A|rcsb pdb:5C7B|rcsb pdb:5C7C|rcsb pdb:5C7D|rcsb pdb:5C83|rcsb pdb:5C84|rcsb pdb:5M6E|rcsb pdb:5M6F|rcsb pdb:5M6H|rcsb pdb:5M6L|rcsb pdb:5M6M|rcsb pdb:5O6T|rcsb pdb:5OQW|rcsb pdb:6EY2|rcsb pdb:6GJW|rcsb pdb:6QCI|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-111469|reactome:R-HSA-3769402|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-9627069	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	go:"GO:0005874"(microtubule)	-	-	figure legend:4A|comment:Beta-Tubulin also colocalised with HTRA4 but the identity of the tubulin molecule is not known. Actin did not colocalise with HTRA4.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mda_mb_231)|taxid:9606(Homo sapiens Caucasian breast adenocarcinoma)	-	2020/03/13	2020/07/01	rogid:6eDcOay+c2ZmIAD/pwnCDROBwgM9606	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rigid:3b25XRC17oFKztpV8xz6mmTQVE8	false	-	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:P17987	uniprotkb:P83105	intact:EBI-356553|uniprotkb:Q15556|uniprotkb:Q5TCM3|uniprotkb:E1P5B2|ensembl:ENSP00000317334	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	psi-mi:tcpa_human(display_long)|uniprotkb:CCTA(gene name synonym)|uniprotkb:TCP1(gene name)|psi-mi:TCP1(display_short)|uniprotkb:CCT1(gene name synonym)|uniprotkb:CCT-alpha(gene name synonym)	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745415|imex:IM-28152-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_110379.2|ensembl:ENSG00000120438(gene)|ensembl:ENST00000321394(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000792"(heterochromatin)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:2000109"(regulation of macrophage apoptotic process)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044053"(translocation of peptides or proteins into host cell cytoplasm)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|interpro:IPR012715(T-complex protein 1, alpha subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|reactome:R-HSA-8950505|interpro:IPR027413|mint:P17987|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|dip:DIP-33676N	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	go:"GO:0005874"(microtubule)	-	-	figure legend:4A|comment:Beta-Tubulin also colocalised with HTRA4 but the identity of the tubulin molecule is not known. Actin did not colocalise with HTRA4.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mda_mb_231)|taxid:9606(Homo sapiens Caucasian breast adenocarcinoma)	-	2020/03/13	2020/07/01	rogid:CYJ5rPjKOH3sAP+j0ckdHHu81g49606	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rigid:LGtFAQWNOgC42vqR/J4mkxZE4mM	false	-	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:P55210	uniprotkb:P83105	intact:EBI-523958|uniprotkb:B5BU45|uniprotkb:Q5SVL3|uniprotkb:Q13364|uniprotkb:Q96BA0|uniprotkb:Q5SVL0|uniprotkb:Q53YD5|ensembl:ENSP00000298701|ensembl:ENSP00000358321|ensembl:ENSP00000358324|ensembl:ENSP00000480584|uniprotkb:D3DRB8|uniprotkb:B4DQU7	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	psi-mi:casp7_human(display_long)|uniprotkb:ICE-like apoptotic protease 3(gene name synonym)|uniprotkb:Apoptotic protease Mch-3(gene name synonym)|uniprotkb:CMH-1(gene name synonym)|uniprotkb:CASP7(gene name)|psi-mi:CASP7(display_short)|uniprotkb:MCH3(gene name synonym)	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745420|imex:IM-28152-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001218.1|refseq:NP_203124.1|refseq:NP_203125.1|refseq:NP_203126.1|ensembl:ENSG00000165806(gene)|ensembl:ENST00000345633(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|ensembl:ENST00000369315(transcript)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0016485"(protein processing)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0072734"(cellular response to staurosporine)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR015471(Caspase-7)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|mint:P55210|rcsb pdb:1F1J|ensembl:ENST00000369318(transcript)|rcsb pdb:1GQF|ensembl:ENST00000621345(transcript)|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1K86|rcsb pdb:1K88|rcsb pdb:1KMC|rcsb pdb:1MIA|rcsb pdb:1SHJ|go:"GO:0004190"(aspartic-type endopeptidase activity)|rcsb pdb:1SHL|rcsb pdb:2QL5|go:"GO:0004197"(cysteine-type endopeptidase activity)|rcsb pdb:2QL7|go:"GO:0005634"(nucleus)|rcsb pdb:2QL9|rcsb pdb:2QLB|rcsb pdb:2QLF|rcsb pdb:2QLJ|rcsb pdb:3EDR|go:"GO:0005654"(nucleoplasm)|rcsb pdb:3H1P|rcsb pdb:3IBC|rcsb pdb:3IBF|rcsb pdb:3R5K|rcsb pdb:4FDL|rcsb pdb:4FEA|rcsb pdb:4HQ0|rcsb pdb:4HQR|rcsb pdb:4JB8|reactome:R-HSA-111464|reactome:R-HSA-111465|reactome:R-HSA-111469|reactome:R-HSA-264870|rcsb pdb:4JJ8|rcsb pdb:4JR1|rcsb pdb:4JR2|rcsb pdb:4LSZ|rcsb pdb:4ZVO|rcsb pdb:4ZVP|rcsb pdb:4ZVQ|rcsb pdb:4ZVR|rcsb pdb:4ZVS|rcsb pdb:4ZVT|rcsb pdb:4ZVU|rcsb pdb:5IC6|rcsb pdb:5K20|rcsb pdb:5V6U|rcsb pdb:5V6Z|reactome:R-HSA-111459|reactome:R-HSA-111463|refseq:NP_001253986.1|refseq:NP_001253987.1|refseq:NP_001253985.1|refseq:NP_001307840.1|dip:DIP-29973N	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	go:"GO:0005874"(microtubule)	-	-	figure legend:4A|comment:Beta-Tubulin also colocalised with HTRA4 but the identity of the tubulin molecule is not known. Actin did not colocalise with HTRA4.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mda_mb_231)|taxid:9606(Homo sapiens Caucasian breast adenocarcinoma)	-	2020/03/13	2020/07/01	rogid:XcSWtfWWnuOKIbAR+TXpkCq5fig9606	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rigid:Tm7ij0S2iFhaMsZ94n8RhdfIcOU	false	-	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:P55211	uniprotkb:P83105	intact:EBI-516799|uniprotkb:O95348|uniprotkb:Q92852|uniprotkb:Q9BQ62|uniprotkb:Q9UEQ3|uniprotkb:Q9UIJ8|uniprotkb:Q53Y70|uniprotkb:Q5JRU9|uniprotkb:Q5UGI1|uniprotkb:B4E1A3|ensembl:ENSP00000330237	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	psi-mi:casp9_human(display_long)|uniprotkb:ICE-like apoptotic protease 6(gene name synonym)|uniprotkb:Apoptotic protease Mch-6(gene name synonym)|uniprotkb:Apoptotic protease-activating factor 3(gene name synonym)|uniprotkb:CASP9(gene name)|psi-mi:CASP9(display_short)|uniprotkb:MCH6(gene name synonym)	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745425|imex:IM-28152-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001264983.1|refseq:NP_001220.2|refseq:NP_127463.2|refseq:XP_005246071.1|dip:DIP-27625N|ensembl:ENSG00000132906(gene)|ensembl:ENST00000333868(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002931"(response to ischemia)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007568"(aging)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008233"(peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030220"(platelet formation)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043293"(apoptosome)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033171|interpro:IPR042147|mint:P55211|rcsb pdb:1JXQ|rcsb pdb:1NW9|rcsb pdb:2AR9|rcsb pdb:3D9T|rcsb pdb:3V3K|rcsb pdb:3YGS|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|rcsb pdb:5WVE|reactome:R-HSA-111458|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-168638|reactome:R-HSA-198323|reactome:R-HSA-418889|reactome:R-HSA-5674400|reactome:R-HSA-9627069	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	go:"GO:0005874"(microtubule)	-	-	figure legend:4A|comment:Beta-Tubulin also colocalised with HTRA4 but the identity of the tubulin molecule is not known. Actin did not colocalise with HTRA4.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mda_mb_231)|taxid:9606(Homo sapiens Caucasian breast adenocarcinoma)	-	2020/03/13	2020/07/01	rogid:IYW59Vh17AEnXa6/wLpkIPNE0Bo9606	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rigid:eeNQ/IpGSY0P7JyDSgid+RBcWKI	false	-	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:P83105	uniprotkb:P55211	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-516799|uniprotkb:O95348|uniprotkb:Q92852|uniprotkb:Q9BQ62|uniprotkb:Q9UEQ3|uniprotkb:Q9UIJ8|uniprotkb:Q53Y70|uniprotkb:Q5JRU9|uniprotkb:Q5UGI1|uniprotkb:B4E1A3|ensembl:ENSP00000330237	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:casp9_human(display_long)|uniprotkb:ICE-like apoptotic protease 6(gene name synonym)|uniprotkb:Apoptotic protease Mch-6(gene name synonym)|uniprotkb:Apoptotic protease-activating factor 3(gene name synonym)|uniprotkb:CASP9(gene name)|psi-mi:CASP9(display_short)|uniprotkb:MCH6(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745383|imex:IM-28152-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001264983.1|refseq:NP_001220.2|refseq:NP_127463.2|refseq:XP_005246071.1|dip:DIP-27625N|ensembl:ENSG00000132906(gene)|ensembl:ENST00000333868(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002931"(response to ischemia)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007568"(aging)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008233"(peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030220"(platelet formation)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043293"(apoptosome)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033171|interpro:IPR042147|mint:P55211|rcsb pdb:1JXQ|rcsb pdb:1NW9|rcsb pdb:2AR9|rcsb pdb:3D9T|rcsb pdb:3V3K|rcsb pdb:3YGS|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|rcsb pdb:5WVE|reactome:R-HSA-111458|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-168638|reactome:R-HSA-198323|reactome:R-HSA-418889|reactome:R-HSA-5674400|reactome:R-HSA-9627069	-	-	-	figure legend:Figure 3|comment:"Other molecules were detected but cannot be identified, notably: beta-tubulin and Actin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mda_mb_231)|taxid:9606(Homo sapiens Caucasian breast adenocarcinoma)	-	2020/03/13	2020/07/01	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:IYW59Vh17AEnXa6/wLpkIPNE0Bo9606	rigid:F0j1jBJMdH7zZfUtyMpb8jw8NtM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P83105	uniprotkb:P55210	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-523958|uniprotkb:B5BU45|uniprotkb:Q5SVL3|uniprotkb:Q13364|uniprotkb:Q96BA0|uniprotkb:Q5SVL0|uniprotkb:Q53YD5|ensembl:ENSP00000298701|ensembl:ENSP00000358321|ensembl:ENSP00000358324|ensembl:ENSP00000480584|uniprotkb:D3DRB8|uniprotkb:B4DQU7	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:casp7_human(display_long)|uniprotkb:ICE-like apoptotic protease 3(gene name synonym)|uniprotkb:Apoptotic protease Mch-3(gene name synonym)|uniprotkb:CMH-1(gene name synonym)|uniprotkb:CASP7(gene name)|psi-mi:CASP7(display_short)|uniprotkb:MCH3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745383|imex:IM-28152-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001218.1|refseq:NP_203124.1|refseq:NP_203125.1|refseq:NP_203126.1|ensembl:ENSG00000165806(gene)|ensembl:ENST00000345633(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|ensembl:ENST00000369315(transcript)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0016485"(protein processing)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0072734"(cellular response to staurosporine)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR015471(Caspase-7)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|mint:P55210|rcsb pdb:1F1J|ensembl:ENST00000369318(transcript)|rcsb pdb:1GQF|ensembl:ENST00000621345(transcript)|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1K86|rcsb pdb:1K88|rcsb pdb:1KMC|rcsb pdb:1MIA|rcsb pdb:1SHJ|go:"GO:0004190"(aspartic-type endopeptidase activity)|rcsb pdb:1SHL|rcsb pdb:2QL5|go:"GO:0004197"(cysteine-type endopeptidase activity)|rcsb pdb:2QL7|go:"GO:0005634"(nucleus)|rcsb pdb:2QL9|rcsb pdb:2QLB|rcsb pdb:2QLF|rcsb pdb:2QLJ|rcsb pdb:3EDR|go:"GO:0005654"(nucleoplasm)|rcsb pdb:3H1P|rcsb pdb:3IBC|rcsb pdb:3IBF|rcsb pdb:3R5K|rcsb pdb:4FDL|rcsb pdb:4FEA|rcsb pdb:4HQ0|rcsb pdb:4HQR|rcsb pdb:4JB8|reactome:R-HSA-111464|reactome:R-HSA-111465|reactome:R-HSA-111469|reactome:R-HSA-264870|rcsb pdb:4JJ8|rcsb pdb:4JR1|rcsb pdb:4JR2|rcsb pdb:4LSZ|rcsb pdb:4ZVO|rcsb pdb:4ZVP|rcsb pdb:4ZVQ|rcsb pdb:4ZVR|rcsb pdb:4ZVS|rcsb pdb:4ZVT|rcsb pdb:4ZVU|rcsb pdb:5IC6|rcsb pdb:5K20|rcsb pdb:5V6U|rcsb pdb:5V6Z|reactome:R-HSA-111459|reactome:R-HSA-111463|refseq:NP_001253986.1|refseq:NP_001253987.1|refseq:NP_001253985.1|refseq:NP_001307840.1|dip:DIP-29973N	-	-	-	figure legend:Figure 3|comment:"Other molecules were detected but cannot be identified, notably: beta-tubulin and Actin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mda_mb_231)|taxid:9606(Homo sapiens Caucasian breast adenocarcinoma)	-	2020/03/13	2020/07/01	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:XcSWtfWWnuOKIbAR+TXpkCq5fig9606	rigid:F0j1jBJMdH7zZfUtyMpb8jw8NtM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P83105	uniprotkb:P98170	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-517127|uniprotkb:Q9NQ14|uniprotkb:D3DTF2|ensembl:ENSP00000347858|ensembl:ENSP00000360242|ensembl:ENSP00000395230	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:xiap_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 3(gene name synonym)|uniprotkb:X-linked inhibitor of apoptosis protein(gene name synonym)|uniprotkb:IAP-like protein(gene name synonym)|uniprotkb:XIAP(gene name)|psi-mi:XIAP(display_short)|uniprotkb:API3(gene name synonym)|uniprotkb:IAP3(gene name synonym)|uniprotkb:BIRC4(gene name synonym)|uniprotkb:Baculoviral IAP repeat-containing protein 4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase XIAP(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745383|imex:IM-28152-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:XP_006724817.1|refseq:NP_001158.2|refseq:NP_001191330.1|refseq:XP_011529631.1|dip:DIP-27626N|ensembl:ENSG00000101966(gene)|ensembl:ENST00000355640(transcript)|ensembl:ENST00000371199(transcript)|ensembl:ENST00000434753(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055070"(copper ion homeostasis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR042579|mint:P98170|rcsb pdb:1C9Q|rcsb pdb:1F9X|rcsb pdb:1G3F|rcsb pdb:1G73|rcsb pdb:1I3O|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1KMC|rcsb pdb:1NW9|rcsb pdb:1TFQ|rcsb pdb:1TFT|rcsb pdb:2ECG|rcsb pdb:2JK7|rcsb pdb:2KNA|rcsb pdb:2OPY|rcsb pdb:2OPZ|rcsb pdb:2POI|rcsb pdb:2POP|rcsb pdb:2QRA|rcsb pdb:2VSL|rcsb pdb:3CLX|rcsb pdb:3CM2|rcsb pdb:3CM7|rcsb pdb:3EYL|rcsb pdb:3G76|rcsb pdb:3HL5|rcsb pdb:3UW4|rcsb pdb:3UW5|rcsb pdb:4EC4|rcsb pdb:4HY0|rcsb pdb:4IC2|rcsb pdb:4IC3|rcsb pdb:4J3Y|rcsb pdb:4J44|rcsb pdb:4J45|rcsb pdb:4J46|rcsb pdb:4J47|rcsb pdb:4J48|rcsb pdb:4KJU|rcsb pdb:4KJV|rcsb pdb:4KMP|rcsb pdb:4MTZ|rcsb pdb:4OXC|rcsb pdb:4WVS|rcsb pdb:4WVT|rcsb pdb:4WVU|rcsb pdb:5C0K|rcsb pdb:5C0L|rcsb pdb:5C3H|rcsb pdb:5C3K|rcsb pdb:5C7A|rcsb pdb:5C7B|rcsb pdb:5C7C|rcsb pdb:5C7D|rcsb pdb:5C83|rcsb pdb:5C84|rcsb pdb:5M6E|rcsb pdb:5M6F|rcsb pdb:5M6H|rcsb pdb:5M6L|rcsb pdb:5M6M|rcsb pdb:5O6T|rcsb pdb:5OQW|rcsb pdb:6EY2|rcsb pdb:6GJW|rcsb pdb:6QCI|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-111469|reactome:R-HSA-3769402|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-9627069	-	-	-	figure legend:Figure 3|comment:"Other molecules were detected but cannot be identified, notably: beta-tubulin and Actin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mda_mb_231)|taxid:9606(Homo sapiens Caucasian breast adenocarcinoma)	-	2020/03/13	2020/07/01	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:6eDcOay+c2ZmIAD/pwnCDROBwgM9606	rigid:F0j1jBJMdH7zZfUtyMpb8jw8NtM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P83105	uniprotkb:P06703	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-352877|ensembl:ENSP00000357708|ensembl:ENSP00000357709|ensembl:ENSP00000473589|uniprotkb:Q5RHS4|uniprotkb:D3DV39	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:s10a6_human(display_long)|uniprotkb:S100A6(gene name)|psi-mi:S100A6(display_short)|uniprotkb:CACY(gene name synonym)|uniprotkb:S100 calcium-binding protein A6(gene name synonym)|uniprotkb:Calcyclin(gene name synonym)|uniprotkb:Prolactin receptor-associated protein(gene name synonym)|uniprotkb:Growth factor-inducible protein 2A9(gene name synonym)|uniprotkb:MLN 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745383|imex:IM-28152-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENSG00000197956(gene)|ensembl:ENST00000368719(transcript)|ensembl:ENST00000368720(transcript)|ensembl:ENST00000496817(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015075"(ion transmembrane transporter activity)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044548"(S100 protein binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|interpro:IPR034118|mint:P06703|rcsb pdb:1K8U|rcsb pdb:1K96|rcsb pdb:1K9K|rcsb pdb:1K9P|rcsb pdb:2M1K|rcsb pdb:4YBH|go:"GO:0062023"(collagen-containing extracellular matrix)|refseq:NP_055439.1|refseq:XP_016857522.1	-	-	-	figure legend:Figure 3|comment:"Other molecules were detected but cannot be identified, notably: beta-tubulin and Actin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mda_mb_231)|taxid:9606(Homo sapiens Caucasian breast adenocarcinoma)	-	2020/03/13	2020/07/01	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:y8rq2lO1c3DEoVaKnfoLEAHsqmo9606	rigid:F0j1jBJMdH7zZfUtyMpb8jw8NtM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P83105	uniprotkb:P17987	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-356553|uniprotkb:Q15556|uniprotkb:Q5TCM3|uniprotkb:E1P5B2|ensembl:ENSP00000317334	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:tcpa_human(display_long)|uniprotkb:CCTA(gene name synonym)|uniprotkb:TCP1(gene name)|psi-mi:TCP1(display_short)|uniprotkb:CCT1(gene name synonym)|uniprotkb:CCT-alpha(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745383|imex:IM-28152-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_110379.2|ensembl:ENSG00000120438(gene)|ensembl:ENST00000321394(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000792"(heterochromatin)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:2000109"(regulation of macrophage apoptotic process)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044053"(translocation of peptides or proteins into host cell cytoplasm)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|interpro:IPR012715(T-complex protein 1, alpha subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|reactome:R-HSA-8950505|interpro:IPR027413|mint:P17987|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|dip:DIP-33676N	-	-	-	figure legend:Figure 3|comment:"Other molecules were detected but cannot be identified, notably: beta-tubulin and Actin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mda_mb_231)|taxid:9606(Homo sapiens Caucasian breast adenocarcinoma)	-	2020/03/13	2020/07/01	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:CYJ5rPjKOH3sAP+j0ckdHHu81g49606	rigid:F0j1jBJMdH7zZfUtyMpb8jw8NtM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P17987	uniprotkb:P83105	intact:EBI-356553|uniprotkb:Q15556|uniprotkb:Q5TCM3|uniprotkb:E1P5B2|ensembl:ENSP00000317334	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	psi-mi:tcpa_human(display_long)|uniprotkb:CCTA(gene name synonym)|uniprotkb:TCP1(gene name)|psi-mi:TCP1(display_short)|uniprotkb:CCT1(gene name synonym)|uniprotkb:CCT-alpha(gene name synonym)	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:"MI:0813"(proximity ligation assay)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745451|imex:IM-28152-33	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_110379.2|ensembl:ENSG00000120438(gene)|ensembl:ENST00000321394(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000792"(heterochromatin)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:2000109"(regulation of macrophage apoptotic process)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044053"(translocation of peptides or proteins into host cell cytoplasm)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|interpro:IPR012715(T-complex protein 1, alpha subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|reactome:R-HSA-8950505|interpro:IPR027413|mint:P17987|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|dip:DIP-33676N	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	-	-	-	figure legend:4B, Supp. Figs 2+3|comment:HtrA4 also formed complexes with beta- tubulin,  but the identity of the tubulin molecule is not known. Actin did not form complexes with HTRA4.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mda_mb_231)|taxid:9606(Homo sapiens Caucasian breast adenocarcinoma)	-	2020/03/13	2020/07/01	rogid:CYJ5rPjKOH3sAP+j0ckdHHu81g49606	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rigid:LGtFAQWNOgC42vqR/J4mkxZE4mM	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P55210	uniprotkb:P83105	intact:EBI-523958|uniprotkb:B5BU45|uniprotkb:Q5SVL3|uniprotkb:Q13364|uniprotkb:Q96BA0|uniprotkb:Q5SVL0|uniprotkb:Q53YD5|ensembl:ENSP00000298701|ensembl:ENSP00000358321|ensembl:ENSP00000358324|ensembl:ENSP00000480584|uniprotkb:D3DRB8|uniprotkb:B4DQU7	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	psi-mi:casp7_human(display_long)|uniprotkb:ICE-like apoptotic protease 3(gene name synonym)|uniprotkb:Apoptotic protease Mch-3(gene name synonym)|uniprotkb:CMH-1(gene name synonym)|uniprotkb:CASP7(gene name)|psi-mi:CASP7(display_short)|uniprotkb:MCH3(gene name synonym)	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:"MI:0813"(proximity ligation assay)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745446|imex:IM-28152-45	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001218.1|refseq:NP_203124.1|refseq:NP_203125.1|refseq:NP_203126.1|ensembl:ENSG00000165806(gene)|ensembl:ENST00000345633(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|ensembl:ENST00000369315(transcript)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0016485"(protein processing)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0072734"(cellular response to staurosporine)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR015471(Caspase-7)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|mint:P55210|rcsb pdb:1F1J|ensembl:ENST00000369318(transcript)|rcsb pdb:1GQF|ensembl:ENST00000621345(transcript)|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1K86|rcsb pdb:1K88|rcsb pdb:1KMC|rcsb pdb:1MIA|rcsb pdb:1SHJ|go:"GO:0004190"(aspartic-type endopeptidase activity)|rcsb pdb:1SHL|rcsb pdb:2QL5|go:"GO:0004197"(cysteine-type endopeptidase activity)|rcsb pdb:2QL7|go:"GO:0005634"(nucleus)|rcsb pdb:2QL9|rcsb pdb:2QLB|rcsb pdb:2QLF|rcsb pdb:2QLJ|rcsb pdb:3EDR|go:"GO:0005654"(nucleoplasm)|rcsb pdb:3H1P|rcsb pdb:3IBC|rcsb pdb:3IBF|rcsb pdb:3R5K|rcsb pdb:4FDL|rcsb pdb:4FEA|rcsb pdb:4HQ0|rcsb pdb:4HQR|rcsb pdb:4JB8|reactome:R-HSA-111464|reactome:R-HSA-111465|reactome:R-HSA-111469|reactome:R-HSA-264870|rcsb pdb:4JJ8|rcsb pdb:4JR1|rcsb pdb:4JR2|rcsb pdb:4LSZ|rcsb pdb:4ZVO|rcsb pdb:4ZVP|rcsb pdb:4ZVQ|rcsb pdb:4ZVR|rcsb pdb:4ZVS|rcsb pdb:4ZVT|rcsb pdb:4ZVU|rcsb pdb:5IC6|rcsb pdb:5K20|rcsb pdb:5V6U|rcsb pdb:5V6Z|reactome:R-HSA-111459|reactome:R-HSA-111463|refseq:NP_001253986.1|refseq:NP_001253987.1|refseq:NP_001253985.1|refseq:NP_001307840.1|dip:DIP-29973N	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	-	-	-	figure legend:4B, Supp. Figs 2+3|comment:HtrA4 also formed complexes with beta- tubulin,  but the identity of the tubulin molecule is not known. Actin did not form complexes with HTRA4.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mda_mb_231)|taxid:9606(Homo sapiens Caucasian breast adenocarcinoma)	-	2020/03/13	2020/07/01	rogid:XcSWtfWWnuOKIbAR+TXpkCq5fig9606	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rigid:Tm7ij0S2iFhaMsZ94n8RhdfIcOU	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P98170	uniprotkb:P83105	intact:EBI-517127|uniprotkb:Q9NQ14|uniprotkb:D3DTF2|ensembl:ENSP00000347858|ensembl:ENSP00000360242|ensembl:ENSP00000395230	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	psi-mi:xiap_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 3(gene name synonym)|uniprotkb:X-linked inhibitor of apoptosis protein(gene name synonym)|uniprotkb:IAP-like protein(gene name synonym)|uniprotkb:XIAP(gene name)|psi-mi:XIAP(display_short)|uniprotkb:API3(gene name synonym)|uniprotkb:IAP3(gene name synonym)|uniprotkb:BIRC4(gene name synonym)|uniprotkb:Baculoviral IAP repeat-containing protein 4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase XIAP(gene name synonym)	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:"MI:0813"(proximity ligation assay)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745436|imex:IM-28152-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006724817.1|refseq:NP_001158.2|refseq:NP_001191330.1|refseq:XP_011529631.1|dip:DIP-27626N|ensembl:ENSG00000101966(gene)|ensembl:ENST00000355640(transcript)|ensembl:ENST00000371199(transcript)|ensembl:ENST00000434753(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055070"(copper ion homeostasis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR042579|mint:P98170|rcsb pdb:1C9Q|rcsb pdb:1F9X|rcsb pdb:1G3F|rcsb pdb:1G73|rcsb pdb:1I3O|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1KMC|rcsb pdb:1NW9|rcsb pdb:1TFQ|rcsb pdb:1TFT|rcsb pdb:2ECG|rcsb pdb:2JK7|rcsb pdb:2KNA|rcsb pdb:2OPY|rcsb pdb:2OPZ|rcsb pdb:2POI|rcsb pdb:2POP|rcsb pdb:2QRA|rcsb pdb:2VSL|rcsb pdb:3CLX|rcsb pdb:3CM2|rcsb pdb:3CM7|rcsb pdb:3EYL|rcsb pdb:3G76|rcsb pdb:3HL5|rcsb pdb:3UW4|rcsb pdb:3UW5|rcsb pdb:4EC4|rcsb pdb:4HY0|rcsb pdb:4IC2|rcsb pdb:4IC3|rcsb pdb:4J3Y|rcsb pdb:4J44|rcsb pdb:4J45|rcsb pdb:4J46|rcsb pdb:4J47|rcsb pdb:4J48|rcsb pdb:4KJU|rcsb pdb:4KJV|rcsb pdb:4KMP|rcsb pdb:4MTZ|rcsb pdb:4OXC|rcsb pdb:4WVS|rcsb pdb:4WVT|rcsb pdb:4WVU|rcsb pdb:5C0K|rcsb pdb:5C0L|rcsb pdb:5C3H|rcsb pdb:5C3K|rcsb pdb:5C7A|rcsb pdb:5C7B|rcsb pdb:5C7C|rcsb pdb:5C7D|rcsb pdb:5C83|rcsb pdb:5C84|rcsb pdb:5M6E|rcsb pdb:5M6F|rcsb pdb:5M6H|rcsb pdb:5M6L|rcsb pdb:5M6M|rcsb pdb:5O6T|rcsb pdb:5OQW|rcsb pdb:6EY2|rcsb pdb:6GJW|rcsb pdb:6QCI|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-111469|reactome:R-HSA-3769402|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-9627069	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	-	-	-	figure legend:4B, Supp. Figs 2+3.|comment:HtrA4 also formed complexes with beta- tubulin,  but the identity of the tubulin molecule is not known. Actin did not form complexes with HTRA4.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mda_mb_231)|taxid:9606(Homo sapiens Caucasian breast adenocarcinoma)	-	2020/03/13	2020/07/01	rogid:6eDcOay+c2ZmIAD/pwnCDROBwgM9606	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rigid:3b25XRC17oFKztpV8xz6mmTQVE8	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P55211	uniprotkb:P83105	intact:EBI-516799|uniprotkb:O95348|uniprotkb:Q92852|uniprotkb:Q9BQ62|uniprotkb:Q9UEQ3|uniprotkb:Q9UIJ8|uniprotkb:Q53Y70|uniprotkb:Q5JRU9|uniprotkb:Q5UGI1|uniprotkb:B4E1A3|ensembl:ENSP00000330237	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	psi-mi:casp9_human(display_long)|uniprotkb:ICE-like apoptotic protease 6(gene name synonym)|uniprotkb:Apoptotic protease Mch-6(gene name synonym)|uniprotkb:Apoptotic protease-activating factor 3(gene name synonym)|uniprotkb:CASP9(gene name)|psi-mi:CASP9(display_short)|uniprotkb:MCH6(gene name synonym)	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:"MI:0813"(proximity ligation assay)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745441|imex:IM-28152-43	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001264983.1|refseq:NP_001220.2|refseq:NP_127463.2|refseq:XP_005246071.1|dip:DIP-27625N|ensembl:ENSG00000132906(gene)|ensembl:ENST00000333868(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002931"(response to ischemia)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007568"(aging)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008233"(peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030220"(platelet formation)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043293"(apoptosome)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033171|interpro:IPR042147|mint:P55211|rcsb pdb:1JXQ|rcsb pdb:1NW9|rcsb pdb:2AR9|rcsb pdb:3D9T|rcsb pdb:3V3K|rcsb pdb:3YGS|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|rcsb pdb:5WVE|reactome:R-HSA-111458|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-168638|reactome:R-HSA-198323|reactome:R-HSA-418889|reactome:R-HSA-5674400|reactome:R-HSA-9627069	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	-	-	-	figure legend:4B,Supp. Figs 2+3|comment:HtrA4 also formed complexes with beta- tubulin,  but the identity of the tubulin molecule is not known. Actin did not form complexes with HTRA4.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mda_mb_231)|taxid:9606(Homo sapiens Caucasian breast adenocarcinoma)	-	2020/03/13	2020/07/01	rogid:IYW59Vh17AEnXa6/wLpkIPNE0Bo9606	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rigid:eeNQ/IpGSY0P7JyDSgid+RBcWKI	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P83105	uniprotkb:P83105	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:"MI:0071"(molecular sieving)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745917|imex:IM-28152-35	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	-	-	-	figure legend:5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rigid:fGhJ63l/4rw847pJb1h+qAX77CA	false	sufficient binding region:147-476|his tag:c-c	sufficient binding region:147-476|his tag:c-c	3	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P83105	intact:EBI-25745968	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	-	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:substrate_peptide(display_short)|psi-mi:EBI-25745968(display_long)	psi-mi:"MI:0990"(cleavage assay)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25745990|imex:IM-28152-11	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	-	-	-	no-uniprot-update:yes	figure legend:7 A/B, Table 5|comment:DeltaN-HtrA4 proteolytic activity is comparatively low in comparison to HtrA2 and HtrA3 .|kinetics:88.3 pM product s -1 μM -1 enzyme  Vmax = 21.8pM/sec|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kcat:1.09x10^-4(second -1)|km:0.162x10^-6(molar)	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:Dxdl6K4MHmUR6rbm9aqMnpF8IEY-2	rigid:5EMm/DAqJPBOk8PLcfAKoh1Oxgc	false	sufficient binding region:147-476|his tag:c-c	coumarin label:1-2|modified L-phenylalanine residue:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P83105	uniprotkb:P98170	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-517127|uniprotkb:Q9NQ14|uniprotkb:D3DTF2|ensembl:ENSP00000347858|ensembl:ENSP00000360242|ensembl:ENSP00000395230	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:xiap_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 3(gene name synonym)|uniprotkb:X-linked inhibitor of apoptosis protein(gene name synonym)|uniprotkb:IAP-like protein(gene name synonym)|uniprotkb:XIAP(gene name)|psi-mi:XIAP(display_short)|uniprotkb:API3(gene name synonym)|uniprotkb:IAP3(gene name synonym)|uniprotkb:BIRC4(gene name synonym)|uniprotkb:Baculoviral IAP repeat-containing protein 4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase XIAP(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25746029|imex:IM-28152-13	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:XP_006724817.1|refseq:NP_001158.2|refseq:NP_001191330.1|refseq:XP_011529631.1|dip:DIP-27626N|ensembl:ENSG00000101966(gene)|ensembl:ENST00000355640(transcript)|ensembl:ENST00000371199(transcript)|ensembl:ENST00000434753(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055070"(copper ion homeostasis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR042579|mint:P98170|rcsb pdb:1C9Q|rcsb pdb:1F9X|rcsb pdb:1G3F|rcsb pdb:1G73|rcsb pdb:1I3O|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1KMC|rcsb pdb:1NW9|rcsb pdb:1TFQ|rcsb pdb:1TFT|rcsb pdb:2ECG|rcsb pdb:2JK7|rcsb pdb:2KNA|rcsb pdb:2OPY|rcsb pdb:2OPZ|rcsb pdb:2POI|rcsb pdb:2POP|rcsb pdb:2QRA|rcsb pdb:2VSL|rcsb pdb:3CLX|rcsb pdb:3CM2|rcsb pdb:3CM7|rcsb pdb:3EYL|rcsb pdb:3G76|rcsb pdb:3HL5|rcsb pdb:3UW4|rcsb pdb:3UW5|rcsb pdb:4EC4|rcsb pdb:4HY0|rcsb pdb:4IC2|rcsb pdb:4IC3|rcsb pdb:4J3Y|rcsb pdb:4J44|rcsb pdb:4J45|rcsb pdb:4J46|rcsb pdb:4J47|rcsb pdb:4J48|rcsb pdb:4KJU|rcsb pdb:4KJV|rcsb pdb:4KMP|rcsb pdb:4MTZ|rcsb pdb:4OXC|rcsb pdb:4WVS|rcsb pdb:4WVT|rcsb pdb:4WVU|rcsb pdb:5C0K|rcsb pdb:5C0L|rcsb pdb:5C3H|rcsb pdb:5C3K|rcsb pdb:5C7A|rcsb pdb:5C7B|rcsb pdb:5C7C|rcsb pdb:5C7D|rcsb pdb:5C83|rcsb pdb:5C84|rcsb pdb:5M6E|rcsb pdb:5M6F|rcsb pdb:5M6H|rcsb pdb:5M6L|rcsb pdb:5M6M|rcsb pdb:5O6T|rcsb pdb:5OQW|rcsb pdb:6EY2|rcsb pdb:6GJW|rcsb pdb:6QCI|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-111469|reactome:R-HSA-3769402|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-9627069	-	-	-	figure legend:7 C, number 1|comment:"It is stated that:-  \"We observed that Delta N-HtrA4 did degrade  recombinant XIAP, though less efficiently compared to the Delta N-HtrA2 and − 3 proteases (Fig. 7C)\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:6eDcOay+c2ZmIAD/pwnCDROBwgM9606	rigid:3b25XRC17oFKztpV8xz6mmTQVE8	false	sufficient binding region:147-476|his tag:c-c	his tag:c-c	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P83110	uniprotkb:P98170	intact:EBI-2867394|uniprotkb:Q7Z7A2|ensembl:ENSP00000303766	intact:EBI-517127|uniprotkb:Q9NQ14|uniprotkb:D3DTF2|ensembl:ENSP00000347858|ensembl:ENSP00000360242|ensembl:ENSP00000395230	psi-mi:htra3_human(display_long)|uniprotkb:HTRA3(gene name)|psi-mi:HTRA3(display_short)|uniprotkb:PRSP(gene name synonym)|uniprotkb:High-temperature requirement factor A3(gene name synonym)|uniprotkb:Pregnancy-related serine protease(gene name synonym)	psi-mi:xiap_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 3(gene name synonym)|uniprotkb:X-linked inhibitor of apoptosis protein(gene name synonym)|uniprotkb:IAP-like protein(gene name synonym)|uniprotkb:XIAP(gene name)|psi-mi:XIAP(display_short)|uniprotkb:API3(gene name synonym)|uniprotkb:IAP3(gene name synonym)|uniprotkb:BIRC4(gene name synonym)|uniprotkb:Baculoviral IAP repeat-containing protein 4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase XIAP(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25746048|imex:IM-28152-47	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001284488.1|refseq:NP_444272.1|ensembl:ENSG00000170801(gene)|ensembl:ENST00000307358(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058|interpro:IPR041489|rcsb pdb:2P3W|rcsb pdb:4RI0	refseq:XP_006724817.1|refseq:NP_001158.2|refseq:NP_001191330.1|refseq:XP_011529631.1|dip:DIP-27626N|ensembl:ENSG00000101966(gene)|ensembl:ENST00000355640(transcript)|ensembl:ENST00000371199(transcript)|ensembl:ENST00000434753(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055070"(copper ion homeostasis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR042579|mint:P98170|rcsb pdb:1C9Q|rcsb pdb:1F9X|rcsb pdb:1G3F|rcsb pdb:1G73|rcsb pdb:1I3O|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1KMC|rcsb pdb:1NW9|rcsb pdb:1TFQ|rcsb pdb:1TFT|rcsb pdb:2ECG|rcsb pdb:2JK7|rcsb pdb:2KNA|rcsb pdb:2OPY|rcsb pdb:2OPZ|rcsb pdb:2POI|rcsb pdb:2POP|rcsb pdb:2QRA|rcsb pdb:2VSL|rcsb pdb:3CLX|rcsb pdb:3CM2|rcsb pdb:3CM7|rcsb pdb:3EYL|rcsb pdb:3G76|rcsb pdb:3HL5|rcsb pdb:3UW4|rcsb pdb:3UW5|rcsb pdb:4EC4|rcsb pdb:4HY0|rcsb pdb:4IC2|rcsb pdb:4IC3|rcsb pdb:4J3Y|rcsb pdb:4J44|rcsb pdb:4J45|rcsb pdb:4J46|rcsb pdb:4J47|rcsb pdb:4J48|rcsb pdb:4KJU|rcsb pdb:4KJV|rcsb pdb:4KMP|rcsb pdb:4MTZ|rcsb pdb:4OXC|rcsb pdb:4WVS|rcsb pdb:4WVT|rcsb pdb:4WVU|rcsb pdb:5C0K|rcsb pdb:5C0L|rcsb pdb:5C3H|rcsb pdb:5C3K|rcsb pdb:5C7A|rcsb pdb:5C7B|rcsb pdb:5C7C|rcsb pdb:5C7D|rcsb pdb:5C83|rcsb pdb:5C84|rcsb pdb:5M6E|rcsb pdb:5M6F|rcsb pdb:5M6H|rcsb pdb:5M6L|rcsb pdb:5M6M|rcsb pdb:5O6T|rcsb pdb:5OQW|rcsb pdb:6EY2|rcsb pdb:6GJW|rcsb pdb:6QCI|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-111469|reactome:R-HSA-3769402|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-9627069	-	-	-	figure legend:7 C, number 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:oJfuPj+xPZ+WkCu+VlJeqJAr/3k9606	rogid:6eDcOay+c2ZmIAD/pwnCDROBwgM9606	rigid:Lci9SFi+PKZ9HpCu/abzqqzXTrg	false	sufficient binding region:130-453|his tag:c-c	his tag:c-c	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:O43464	uniprotkb:P98170	intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080	intact:EBI-517127|uniprotkb:Q9NQ14|uniprotkb:D3DTF2|ensembl:ENSP00000347858|ensembl:ENSP00000360242|ensembl:ENSP00000395230	psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym)	psi-mi:xiap_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 3(gene name synonym)|uniprotkb:X-linked inhibitor of apoptosis protein(gene name synonym)|uniprotkb:IAP-like protein(gene name synonym)|uniprotkb:XIAP(gene name)|psi-mi:XIAP(display_short)|uniprotkb:API3(gene name synonym)|uniprotkb:IAP3(gene name synonym)|uniprotkb:BIRC4(gene name synonym)|uniprotkb:Baculoviral IAP repeat-containing protein 4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase XIAP(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25746060|imex:IM-28152-37	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN	refseq:XP_006724817.1|refseq:NP_001158.2|refseq:NP_001191330.1|refseq:XP_011529631.1|dip:DIP-27626N|ensembl:ENSG00000101966(gene)|ensembl:ENST00000355640(transcript)|ensembl:ENST00000371199(transcript)|ensembl:ENST00000434753(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055070"(copper ion homeostasis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR042579|mint:P98170|rcsb pdb:1C9Q|rcsb pdb:1F9X|rcsb pdb:1G3F|rcsb pdb:1G73|rcsb pdb:1I3O|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1KMC|rcsb pdb:1NW9|rcsb pdb:1TFQ|rcsb pdb:1TFT|rcsb pdb:2ECG|rcsb pdb:2JK7|rcsb pdb:2KNA|rcsb pdb:2OPY|rcsb pdb:2OPZ|rcsb pdb:2POI|rcsb pdb:2POP|rcsb pdb:2QRA|rcsb pdb:2VSL|rcsb pdb:3CLX|rcsb pdb:3CM2|rcsb pdb:3CM7|rcsb pdb:3EYL|rcsb pdb:3G76|rcsb pdb:3HL5|rcsb pdb:3UW4|rcsb pdb:3UW5|rcsb pdb:4EC4|rcsb pdb:4HY0|rcsb pdb:4IC2|rcsb pdb:4IC3|rcsb pdb:4J3Y|rcsb pdb:4J44|rcsb pdb:4J45|rcsb pdb:4J46|rcsb pdb:4J47|rcsb pdb:4J48|rcsb pdb:4KJU|rcsb pdb:4KJV|rcsb pdb:4KMP|rcsb pdb:4MTZ|rcsb pdb:4OXC|rcsb pdb:4WVS|rcsb pdb:4WVT|rcsb pdb:4WVU|rcsb pdb:5C0K|rcsb pdb:5C0L|rcsb pdb:5C3H|rcsb pdb:5C3K|rcsb pdb:5C7A|rcsb pdb:5C7B|rcsb pdb:5C7C|rcsb pdb:5C7D|rcsb pdb:5C83|rcsb pdb:5C84|rcsb pdb:5M6E|rcsb pdb:5M6F|rcsb pdb:5M6H|rcsb pdb:5M6L|rcsb pdb:5M6M|rcsb pdb:5O6T|rcsb pdb:5OQW|rcsb pdb:6EY2|rcsb pdb:6GJW|rcsb pdb:6QCI|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-111469|reactome:R-HSA-3769402|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-9627069	-	-	-	figure legend:7 C, number 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606	rogid:6eDcOay+c2ZmIAD/pwnCDROBwgM9606	rigid:bxzH7209MB0ZWVgRnjQTyrW1RPY	false	sufficient binding region:134-458|his tag:c-c	his tag:c-c	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P83105	uniprotkb:P02666	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-5260183|uniprotkb:A1YQZ8|uniprotkb:A6N8V0|uniprotkb:Q2TA13|uniprotkb:Q5EEQ6|uniprotkb:Q5EEQ7|uniprotkb:Q6UN63|uniprotkb:Q9BDG5|uniprotkb:Q9TSD5	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:casb_bovin(display_long)|uniprotkb:CSN2(gene name)|psi-mi:CSN2(display_short)	psi-mi:"MI:0435"(protease assay)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25746070|imex:IM-28152-49	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	dip:DIP-46257N|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0009408"(response to heat)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016209"(antioxidant activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:1903488"(negative regulation of lactation)|go:"GO:1903494"(response to dehydroepiandrosterone)|go:"GO:1903496"(response to 11-deoxycorticosterone)|go:"GO:1903720"(negative regulation of I-kappaB phosphorylation)|go:"GO:2000117"(negative regulation of cysteine-type endopeptidase activity)|interpro:IPR001588(Casein, alpha/beta)|interpro:IPR016345(Casein, beta)|interpro:IPR031305	-	-	-	figure legend:7 C, number 4, Supp. fig 4|antagonist:A549 cell lysate|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:wtuOGN4l9NtBjB0YyHhilo7usl49913	rigid:LSGZuvuR9P8vBJpA4EqEhqRKzSE	false	sufficient binding region:147-476|his tag:c-c|mutation disrupting interaction rate:326-326	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P83110	uniprotkb:P02666	intact:EBI-2867394|uniprotkb:Q7Z7A2|ensembl:ENSP00000303766	intact:EBI-5260183|uniprotkb:A1YQZ8|uniprotkb:A6N8V0|uniprotkb:Q2TA13|uniprotkb:Q5EEQ6|uniprotkb:Q5EEQ7|uniprotkb:Q6UN63|uniprotkb:Q9BDG5|uniprotkb:Q9TSD5	psi-mi:htra3_human(display_long)|uniprotkb:HTRA3(gene name)|psi-mi:HTRA3(display_short)|uniprotkb:PRSP(gene name synonym)|uniprotkb:High-temperature requirement factor A3(gene name synonym)|uniprotkb:Pregnancy-related serine protease(gene name synonym)	psi-mi:casb_bovin(display_long)|uniprotkb:CSN2(gene name)|psi-mi:CSN2(display_short)	psi-mi:"MI:0435"(protease assay)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25746081|imex:IM-28152-15	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001284488.1|refseq:NP_444272.1|ensembl:ENSG00000170801(gene)|ensembl:ENST00000307358(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058|interpro:IPR041489|rcsb pdb:2P3W|rcsb pdb:4RI0	dip:DIP-46257N|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0009408"(response to heat)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016209"(antioxidant activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:1903488"(negative regulation of lactation)|go:"GO:1903494"(response to dehydroepiandrosterone)|go:"GO:1903496"(response to 11-deoxycorticosterone)|go:"GO:1903720"(negative regulation of I-kappaB phosphorylation)|go:"GO:2000117"(negative regulation of cysteine-type endopeptidase activity)|interpro:IPR001588(Casein, alpha/beta)|interpro:IPR016345(Casein, beta)|interpro:IPR031305	-	-	-	figure legend:7 C, number 5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:oJfuPj+xPZ+WkCu+VlJeqJAr/3k9606	rogid:wtuOGN4l9NtBjB0YyHhilo7usl49913	rigid:9N/ict3REurhr/o2Qyinh9oGd88	false	sufficient binding region:130-453|his tag:c-c	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:O43464	uniprotkb:P02666	intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080	intact:EBI-5260183|uniprotkb:A1YQZ8|uniprotkb:A6N8V0|uniprotkb:Q2TA13|uniprotkb:Q5EEQ6|uniprotkb:Q5EEQ7|uniprotkb:Q6UN63|uniprotkb:Q9BDG5|uniprotkb:Q9TSD5	psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym)	psi-mi:casb_bovin(display_long)|uniprotkb:CSN2(gene name)|psi-mi:CSN2(display_short)	psi-mi:"MI:0435"(protease assay)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25746091|imex:IM-28152-39	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN	dip:DIP-46257N|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0009408"(response to heat)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016209"(antioxidant activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:1903488"(negative regulation of lactation)|go:"GO:1903494"(response to dehydroepiandrosterone)|go:"GO:1903496"(response to 11-deoxycorticosterone)|go:"GO:1903720"(negative regulation of I-kappaB phosphorylation)|go:"GO:2000117"(negative regulation of cysteine-type endopeptidase activity)|interpro:IPR001588(Casein, alpha/beta)|interpro:IPR016345(Casein, beta)|interpro:IPR031305	-	-	-	figure legend:7 C, number 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606	rogid:wtuOGN4l9NtBjB0YyHhilo7usl49913	rigid:Kh2SPnSwjU1XP1CcvPFh+4SazTo	false	sufficient binding region:134-458|his tag:c-c	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P83105	uniprotkb:P55210	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-523958|uniprotkb:B5BU45|uniprotkb:Q5SVL3|uniprotkb:Q13364|uniprotkb:Q96BA0|uniprotkb:Q5SVL0|uniprotkb:Q53YD5|ensembl:ENSP00000298701|ensembl:ENSP00000358321|ensembl:ENSP00000358324|ensembl:ENSP00000480584|uniprotkb:D3DRB8|uniprotkb:B4DQU7	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:casp7_human(display_long)|uniprotkb:ICE-like apoptotic protease 3(gene name synonym)|uniprotkb:Apoptotic protease Mch-3(gene name synonym)|uniprotkb:CMH-1(gene name synonym)|uniprotkb:CASP7(gene name)|psi-mi:CASP7(display_short)|uniprotkb:MCH3(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25746101|imex:IM-28152-17	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:NP_001218.1|refseq:NP_203124.1|refseq:NP_203125.1|refseq:NP_203126.1|ensembl:ENSG00000165806(gene)|ensembl:ENST00000345633(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|ensembl:ENST00000369315(transcript)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0016485"(protein processing)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0072734"(cellular response to staurosporine)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR015471(Caspase-7)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|mint:P55210|rcsb pdb:1F1J|ensembl:ENST00000369318(transcript)|rcsb pdb:1GQF|ensembl:ENST00000621345(transcript)|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1K86|rcsb pdb:1K88|rcsb pdb:1KMC|rcsb pdb:1MIA|rcsb pdb:1SHJ|go:"GO:0004190"(aspartic-type endopeptidase activity)|rcsb pdb:1SHL|rcsb pdb:2QL5|go:"GO:0004197"(cysteine-type endopeptidase activity)|rcsb pdb:2QL7|go:"GO:0005634"(nucleus)|rcsb pdb:2QL9|rcsb pdb:2QLB|rcsb pdb:2QLF|rcsb pdb:2QLJ|rcsb pdb:3EDR|go:"GO:0005654"(nucleoplasm)|rcsb pdb:3H1P|rcsb pdb:3IBC|rcsb pdb:3IBF|rcsb pdb:3R5K|rcsb pdb:4FDL|rcsb pdb:4FEA|rcsb pdb:4HQ0|rcsb pdb:4HQR|rcsb pdb:4JB8|reactome:R-HSA-111464|reactome:R-HSA-111465|reactome:R-HSA-111469|reactome:R-HSA-264870|rcsb pdb:4JJ8|rcsb pdb:4JR1|rcsb pdb:4JR2|rcsb pdb:4LSZ|rcsb pdb:4ZVO|rcsb pdb:4ZVP|rcsb pdb:4ZVQ|rcsb pdb:4ZVR|rcsb pdb:4ZVS|rcsb pdb:4ZVT|rcsb pdb:4ZVU|rcsb pdb:5IC6|rcsb pdb:5K20|rcsb pdb:5V6U|rcsb pdb:5V6Z|reactome:R-HSA-111459|reactome:R-HSA-111463|refseq:NP_001253986.1|refseq:NP_001253987.1|refseq:NP_001253985.1|refseq:NP_001307840.1|dip:DIP-29973N	-	-	-	figure legend:8A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:XcSWtfWWnuOKIbAR+TXpkCq5fig9606	rigid:Tm7ij0S2iFhaMsZ94n8RhdfIcOU	false	mutation disrupting interaction rate:326-326|sufficient binding region:147-476|his tag:c-c	his tag:c-c	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P83105	uniprotkb:P98170	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-517127|uniprotkb:Q9NQ14|uniprotkb:D3DTF2|ensembl:ENSP00000347858|ensembl:ENSP00000360242|ensembl:ENSP00000395230	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:xiap_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 3(gene name synonym)|uniprotkb:X-linked inhibitor of apoptosis protein(gene name synonym)|uniprotkb:IAP-like protein(gene name synonym)|uniprotkb:XIAP(gene name)|psi-mi:XIAP(display_short)|uniprotkb:API3(gene name synonym)|uniprotkb:IAP3(gene name synonym)|uniprotkb:BIRC4(gene name synonym)|uniprotkb:Baculoviral IAP repeat-containing protein 4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase XIAP(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Wenta et al. (2019)	imex:IM-28152|pubmed:31470122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25746121|imex:IM-28152-19	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	refseq:XP_006724817.1|refseq:NP_001158.2|refseq:NP_001191330.1|refseq:XP_011529631.1|dip:DIP-27626N|ensembl:ENSG00000101966(gene)|ensembl:ENST00000355640(transcript)|ensembl:ENST00000371199(transcript)|ensembl:ENST00000434753(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055070"(copper ion homeostasis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR042579|mint:P98170|rcsb pdb:1C9Q|rcsb pdb:1F9X|rcsb pdb:1G3F|rcsb pdb:1G73|rcsb pdb:1I3O|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1KMC|rcsb pdb:1NW9|rcsb pdb:1TFQ|rcsb pdb:1TFT|rcsb pdb:2ECG|rcsb pdb:2JK7|rcsb pdb:2KNA|rcsb pdb:2OPY|rcsb pdb:2OPZ|rcsb pdb:2POI|rcsb pdb:2POP|rcsb pdb:2QRA|rcsb pdb:2VSL|rcsb pdb:3CLX|rcsb pdb:3CM2|rcsb pdb:3CM7|rcsb pdb:3EYL|rcsb pdb:3G76|rcsb pdb:3HL5|rcsb pdb:3UW4|rcsb pdb:3UW5|rcsb pdb:4EC4|rcsb pdb:4HY0|rcsb pdb:4IC2|rcsb pdb:4IC3|rcsb pdb:4J3Y|rcsb pdb:4J44|rcsb pdb:4J45|rcsb pdb:4J46|rcsb pdb:4J47|rcsb pdb:4J48|rcsb pdb:4KJU|rcsb pdb:4KJV|rcsb pdb:4KMP|rcsb pdb:4MTZ|rcsb pdb:4OXC|rcsb pdb:4WVS|rcsb pdb:4WVT|rcsb pdb:4WVU|rcsb pdb:5C0K|rcsb pdb:5C0L|rcsb pdb:5C3H|rcsb pdb:5C3K|rcsb pdb:5C7A|rcsb pdb:5C7B|rcsb pdb:5C7C|rcsb pdb:5C7D|rcsb pdb:5C83|rcsb pdb:5C84|rcsb pdb:5M6E|rcsb pdb:5M6F|rcsb pdb:5M6H|rcsb pdb:5M6L|rcsb pdb:5M6M|rcsb pdb:5O6T|rcsb pdb:5OQW|rcsb pdb:6EY2|rcsb pdb:6GJW|rcsb pdb:6QCI|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-111469|reactome:R-HSA-3769402|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-9627069	-	-	-	figure legend:8C|antagonist:A549 cell lysate -only when not heat treated.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/07/02	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:6eDcOay+c2ZmIAD/pwnCDROBwgM9606	rigid:3b25XRC17oFKztpV8xz6mmTQVE8	false	sufficient binding region:147-476|his tag:c-c|mutation disrupting interaction rate:326-326	his tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)