#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9Y5K2	uniprotkb:P20155	intact:EBI-10224152|uniprotkb:Q9UBJ6|uniprotkb:Q9GZL6|uniprotkb:Q4VB16|uniprotkb:Q96RU5	intact:EBI-10200479|uniprotkb:Q6FGH2|ensembl:ENSP00000248701	psi-mi:klk4_human(display_long)|uniprotkb:KLK4(gene name)|psi-mi:KLK4(display_short)|uniprotkb:EMSP1(gene name synonym)|uniprotkb:Enamel matrix serine proteinase 1(gene name synonym)|uniprotkb:Kallikrein-like protein 1(gene name synonym)|uniprotkb:PRSS17(gene name synonym)|uniprotkb:PSTS(gene name synonym)|uniprotkb:Prostase(gene name synonym)|uniprotkb:Serine protease 17(gene name synonym)	psi-mi:isk2_human(display_long)|uniprotkb:SPINK2(gene name)|psi-mi:SPINK2(display_short)|uniprotkb:Acrosin-trypsin inhibitor(gene name synonym)|uniprotkb:Epididymis tissue protein Li 172(gene name synonym)|uniprotkb:HUSI-II(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Nishimiya et al. (2019)	pubmed:31391482|imex:IM-27903	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25506411|imex:IM-27903-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR033116|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|rcsb pdb:2BDG|rcsb pdb:2BDH|rcsb pdb:2BDI|rcsb pdb:4K1E|rcsb pdb:4K8Y|rcsb pdb:4KEL|rcsb pdb:4KGA|refseq:NP_001289890.1|refseq:NP_004908.4|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030141"(secretory granule)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0046872"(metal ion binding)|go:"GO:0097186"(amelogenesis)|rcsb pdb:6KBR|rcsb pdb:6NVB|rcsb pdb:6O21|interpro:IPR043504	refseq:NP_001258650.1|refseq:NP_001258651.1|refseq:NP_066937.1|ensembl:ENSG00000128040(gene)|ensembl:ENST00000248701(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001675"(acrosome assembly)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0007286"(spermatid development)|go:"GO:1900004"(negative regulation of serine-type endopeptidase activity)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR036058|interpro:IPR042167|rcsb pdb:2JXD|rcsb pdb:6KBR	-	-	-	figure legend:Table 3, Suppl. Figure 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.08x10^-12(molar)|kon:6.99x10^6(per mole per second)|koff:1.45x10^-5(second -1)	2020/04/06	2020/05/05	rogid:xJctuApDMRXSpIDzRqRI2WS/mU09606	rogid:zIpTsfygI9LJc0BSBjC8d4sDW1s9606	rigid:E3zzKgosWnpAdVQySGnq9J83ziw	false	biotin tag:?-?	mutation:37-38,40-43,45-45,47-49|sufficient binding region:23-84	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y5K2	uniprotkb:P20155	intact:EBI-10224152|uniprotkb:Q9UBJ6|uniprotkb:Q9GZL6|uniprotkb:Q4VB16|uniprotkb:Q96RU5	intact:EBI-10200479|uniprotkb:Q6FGH2|ensembl:ENSP00000248701	psi-mi:klk4_human(display_long)|uniprotkb:KLK4(gene name)|psi-mi:KLK4(display_short)|uniprotkb:EMSP1(gene name synonym)|uniprotkb:Enamel matrix serine proteinase 1(gene name synonym)|uniprotkb:Kallikrein-like protein 1(gene name synonym)|uniprotkb:PRSS17(gene name synonym)|uniprotkb:PSTS(gene name synonym)|uniprotkb:Prostase(gene name synonym)|uniprotkb:Serine protease 17(gene name synonym)	psi-mi:isk2_human(display_long)|uniprotkb:SPINK2(gene name)|psi-mi:SPINK2(display_short)|uniprotkb:Acrosin-trypsin inhibitor(gene name synonym)|uniprotkb:Epididymis tissue protein Li 172(gene name synonym)|uniprotkb:HUSI-II(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Nishimiya et al. (2019)	pubmed:31391482|imex:IM-27903	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25567611|imex:IM-27903-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR033116|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|rcsb pdb:2BDG|rcsb pdb:2BDH|rcsb pdb:2BDI|rcsb pdb:4K1E|rcsb pdb:4K8Y|rcsb pdb:4KEL|rcsb pdb:4KGA|refseq:NP_001289890.1|refseq:NP_004908.4|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030141"(secretory granule)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0046872"(metal ion binding)|go:"GO:0097186"(amelogenesis)|rcsb pdb:6KBR|rcsb pdb:6NVB|rcsb pdb:6O21|interpro:IPR043504	refseq:NP_001258650.1|refseq:NP_001258651.1|refseq:NP_066937.1|ensembl:ENSG00000128040(gene)|ensembl:ENST00000248701(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001675"(acrosome assembly)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0007286"(spermatid development)|go:"GO:1900004"(negative regulation of serine-type endopeptidase activity)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR036058|interpro:IPR042167|rcsb pdb:2JXD|rcsb pdb:6KBR	-	-	-	figure legend:Table 3, Suppl. Figure 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kon:4.4x10^6(per mole per second)|koff:1.02x10^-4(second -1)|kd:23.2x10^-12(molar)	2020/04/06	2020/05/05	rogid:xJctuApDMRXSpIDzRqRI2WS/mU09606	rogid:zIpTsfygI9LJc0BSBjC8d4sDW1s9606	rigid:E3zzKgosWnpAdVQySGnq9J83ziw	false	biotin tag:?-?	mutation:37-38,40-43,45-45,47-47,49-49|sufficient binding region:23-84	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y5K2	uniprotkb:P20155	intact:EBI-10224152|uniprotkb:Q9UBJ6|uniprotkb:Q9GZL6|uniprotkb:Q4VB16|uniprotkb:Q96RU5	intact:EBI-10200479|uniprotkb:Q6FGH2|ensembl:ENSP00000248701	psi-mi:klk4_human(display_long)|uniprotkb:KLK4(gene name)|psi-mi:KLK4(display_short)|uniprotkb:EMSP1(gene name synonym)|uniprotkb:Enamel matrix serine proteinase 1(gene name synonym)|uniprotkb:Kallikrein-like protein 1(gene name synonym)|uniprotkb:PRSS17(gene name synonym)|uniprotkb:PSTS(gene name synonym)|uniprotkb:Prostase(gene name synonym)|uniprotkb:Serine protease 17(gene name synonym)	psi-mi:isk2_human(display_long)|uniprotkb:SPINK2(gene name)|psi-mi:SPINK2(display_short)|uniprotkb:Acrosin-trypsin inhibitor(gene name synonym)|uniprotkb:Epididymis tissue protein Li 172(gene name synonym)|uniprotkb:HUSI-II(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Nishimiya et al. (2019)	pubmed:31391482|imex:IM-27903	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25567696|imex:IM-27903-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR033116|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|rcsb pdb:2BDG|rcsb pdb:2BDH|rcsb pdb:2BDI|rcsb pdb:4K1E|rcsb pdb:4K8Y|rcsb pdb:4KEL|rcsb pdb:4KGA|refseq:NP_001289890.1|refseq:NP_004908.4|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030141"(secretory granule)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0046872"(metal ion binding)|go:"GO:0097186"(amelogenesis)|rcsb pdb:6KBR|rcsb pdb:6NVB|rcsb pdb:6O21|interpro:IPR043504	refseq:NP_001258650.1|refseq:NP_001258651.1|refseq:NP_066937.1|ensembl:ENSG00000128040(gene)|ensembl:ENST00000248701(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001675"(acrosome assembly)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0007286"(spermatid development)|go:"GO:1900004"(negative regulation of serine-type endopeptidase activity)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR036058|interpro:IPR042167|rcsb pdb:2JXD|rcsb pdb:6KBR	-	-	-	figure legend:Table 3, Suppl. Figure 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kon:1.16x10^7(per mole per second)|koff:1.03x10^-4(second -1)|kd:8.91x10^-12(molar)	2020/04/06	2020/05/05	rogid:xJctuApDMRXSpIDzRqRI2WS/mU09606	rogid:zIpTsfygI9LJc0BSBjC8d4sDW1s9606	rigid:E3zzKgosWnpAdVQySGnq9J83ziw	false	biotin tag:?-?	sufficient binding region:23-84|mutation:40-42,45-45,47-49,37-38	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P20155	uniprotkb:Q9Y5K2	intact:EBI-10200479|uniprotkb:Q6FGH2|ensembl:ENSP00000248701	intact:EBI-10224152|uniprotkb:Q9UBJ6|uniprotkb:Q9GZL6|uniprotkb:Q4VB16|uniprotkb:Q96RU5	psi-mi:isk2_human(display_long)|uniprotkb:SPINK2(gene name)|psi-mi:SPINK2(display_short)|uniprotkb:Acrosin-trypsin inhibitor(gene name synonym)|uniprotkb:Epididymis tissue protein Li 172(gene name synonym)|uniprotkb:HUSI-II(gene name synonym)	psi-mi:klk4_human(display_long)|uniprotkb:KLK4(gene name)|psi-mi:KLK4(display_short)|uniprotkb:EMSP1(gene name synonym)|uniprotkb:Enamel matrix serine proteinase 1(gene name synonym)|uniprotkb:Kallikrein-like protein 1(gene name synonym)|uniprotkb:PRSS17(gene name synonym)|uniprotkb:PSTS(gene name synonym)|uniprotkb:Prostase(gene name synonym)|uniprotkb:Serine protease 17(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Nishimiya et al. (2019)	pubmed:31391482|imex:IM-27903	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25506624|imex:IM-27903-5|pdbe:6KBR	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001258650.1|refseq:NP_001258651.1|refseq:NP_066937.1|ensembl:ENSG00000128040(gene)|ensembl:ENST00000248701(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001675"(acrosome assembly)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0007286"(spermatid development)|go:"GO:1900004"(negative regulation of serine-type endopeptidase activity)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR036058|interpro:IPR042167|rcsb pdb:2JXD|rcsb pdb:6KBR	interpro:IPR033116|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|rcsb pdb:2BDG|rcsb pdb:2BDH|rcsb pdb:2BDI|rcsb pdb:4K1E|rcsb pdb:4K8Y|rcsb pdb:4KEL|rcsb pdb:4KGA|refseq:NP_001289890.1|refseq:NP_004908.4|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030141"(secretory granule)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0046872"(metal ion binding)|go:"GO:0097186"(amelogenesis)|rcsb pdb:6KBR|rcsb pdb:6NVB|rcsb pdb:6O21|interpro:IPR043504	-	-	-	figure legend:Fig 4, Suppl. Table 3|3d-r-factors:working 18.3%, free 22.6%|3d-resolution:2.0A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/04/06	2020/05/05	rogid:zIpTsfygI9LJc0BSBjC8d4sDW1s9606	rogid:xJctuApDMRXSpIDzRqRI2WS/mU09606	rigid:E3zzKgosWnpAdVQySGnq9J83ziw	false	sufficient binding region:23-84|mutation:37-38,40-42,45-45,47-49	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)