#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:A0A0G2KTI4	uniprotkb:A0A0G2KTI4	intact:EBI-25645251|ensembl:ENSDARP00000135730|intact:EBI-25645293|uniprotkb:A0A0G2KGS0|uniprotkb:C7EA90|uniprotkb:Q6IQW8	intact:EBI-25645251|ensembl:ENSDARP00000135730|intact:EBI-25645293|uniprotkb:A0A0G2KGS0|uniprotkb:C7EA90|uniprotkb:Q6IQW8	psi-mi:s12a2_danre(display_long)|uniprotkb:Na-K-Cl cotransporter 1(gene name synonym)|uniprotkb:nkcc1(gene name synonym)|uniprotkb:slc12a2(gene name)|psi-mi:slc12a2(display_short)	psi-mi:s12a2_danre(display_long)|uniprotkb:Na-K-Cl cotransporter 1(gene name synonym)|uniprotkb:nkcc1(gene name synonym)|uniprotkb:slc12a2(gene name)|psi-mi:slc12a2(display_short)	psi-mi:"MI:0410"(3D electron microscopy)	Chew et al. (2019)	imex:IM-28073|pubmed:31367042	taxid:7955(danre)|taxid:7955("Danio rerio (Zebrafish)")	taxid:7955(danre)|taxid:7955("Danio rerio (Zebrafish)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-25645249|imex:IM-28073-1|wwpdb:6NPH|emdb:EMD-0470|wwpdb:6NPK|emdb:EMD-0472|emdb:EMD-0474	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSDARG00000104573(gene)|ensembl:ENSDART00000169885(transcript)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0008511"("sodium:potassium:chloride symporter activity")|go:"GO:0008519"(ammonium transmembrane transporter activity)|go:"GO:0015377"("cation:chloride symporter activity")|go:"GO:0015379"("potassium:chloride symporter activity")|go:"GO:0015696"|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043583"(ear development)|go:"GO:0048798"(swim bladder inflation)|go:"GO:0055064"(chloride ion homeostasis)|go:"GO:0055075"(potassium ion homeostasis)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR002443(Na-K-Cl co-transporter)|interpro:IPR002444(Na-K-Cl co-transporter 1)|interpro:IPR004841(Amino acid permease-associated region)|interpro:IPR004842(Na-K-Cl cotransporter superfamily)|interpro:IPR013612(Amino acid permease N-terminal)|interpro:IPR018491|rcsb pdb:6NPH|rcsb pdb:6NPJ|rcsb pdb:6NPK|rcsb pdb:6NPL|reactome:R-DRE-426117|refseq:NP_001002080.1|refseq:NP_001157126.1	ensembl:ENSDARG00000104573(gene)|ensembl:ENSDART00000169885(transcript)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0008511"("sodium:potassium:chloride symporter activity")|go:"GO:0008519"(ammonium transmembrane transporter activity)|go:"GO:0015377"("cation:chloride symporter activity")|go:"GO:0015379"("potassium:chloride symporter activity")|go:"GO:0015696"|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043583"(ear development)|go:"GO:0048798"(swim bladder inflation)|go:"GO:0055064"(chloride ion homeostasis)|go:"GO:0055075"(potassium ion homeostasis)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR002443(Na-K-Cl co-transporter)|interpro:IPR002444(Na-K-Cl co-transporter 1)|interpro:IPR004841(Amino acid permease-associated region)|interpro:IPR004842(Na-K-Cl cotransporter superfamily)|interpro:IPR013612(Amino acid permease N-terminal)|interpro:IPR018491|rcsb pdb:6NPH|rcsb pdb:6NPJ|rcsb pdb:6NPK|rcsb pdb:6NPL|reactome:R-DRE-426117|refseq:NP_001002080.1|refseq:NP_001157126.1	-	-	-	figure legend:Fig 1, Extended Data Fig 2, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/06/12	2020/06/12	rogid:StGyX1f0/RnC5mIbRPjBbbp3saU7955	rogid:StGyX1f0/RnC5mIbRPjBbbp3saU7955	rigid:YRXl2LY5nRr4clEl0QPYR3Na0Js	false	-	-	2	0	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:A0A0G2KTI4	uniprotkb:A0A0G2KTI4	intact:EBI-25645251|ensembl:ENSDARP00000135730|intact:EBI-25645293|uniprotkb:A0A0G2KGS0|uniprotkb:C7EA90|uniprotkb:Q6IQW8	intact:EBI-25645251|ensembl:ENSDARP00000135730|intact:EBI-25645293|uniprotkb:A0A0G2KGS0|uniprotkb:C7EA90|uniprotkb:Q6IQW8	psi-mi:s12a2_danre(display_long)|uniprotkb:Na-K-Cl cotransporter 1(gene name synonym)|uniprotkb:nkcc1(gene name synonym)|uniprotkb:slc12a2(gene name)|psi-mi:slc12a2(display_short)	psi-mi:s12a2_danre(display_long)|uniprotkb:Na-K-Cl cotransporter 1(gene name synonym)|uniprotkb:nkcc1(gene name synonym)|uniprotkb:slc12a2(gene name)|psi-mi:slc12a2(display_short)	psi-mi:"MI:0410"(3D electron microscopy)	Chew et al. (2019)	imex:IM-28073|pubmed:31367042	taxid:7955(danre)|taxid:7955("Danio rerio (Zebrafish)")	taxid:7955(danre)|taxid:7955("Danio rerio (Zebrafish)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-25645291|imex:IM-28073-3|wwpdb:6NPJ|emdb:EMD-0471|wwpdb:6NPL|emdb:EMD-0473|emdb:EMD-0475	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSDARG00000104573(gene)|ensembl:ENSDART00000169885(transcript)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0008511"("sodium:potassium:chloride symporter activity")|go:"GO:0008519"(ammonium transmembrane transporter activity)|go:"GO:0015377"("cation:chloride symporter activity")|go:"GO:0015379"("potassium:chloride symporter activity")|go:"GO:0015696"|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043583"(ear development)|go:"GO:0048798"(swim bladder inflation)|go:"GO:0055064"(chloride ion homeostasis)|go:"GO:0055075"(potassium ion homeostasis)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR002443(Na-K-Cl co-transporter)|interpro:IPR002444(Na-K-Cl co-transporter 1)|interpro:IPR004841(Amino acid permease-associated region)|interpro:IPR004842(Na-K-Cl cotransporter superfamily)|interpro:IPR013612(Amino acid permease N-terminal)|interpro:IPR018491|rcsb pdb:6NPH|rcsb pdb:6NPJ|rcsb pdb:6NPK|rcsb pdb:6NPL|reactome:R-DRE-426117|refseq:NP_001002080.1|refseq:NP_001157126.1	ensembl:ENSDARG00000104573(gene)|ensembl:ENSDART00000169885(transcript)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0008511"("sodium:potassium:chloride symporter activity")|go:"GO:0008519"(ammonium transmembrane transporter activity)|go:"GO:0015377"("cation:chloride symporter activity")|go:"GO:0015379"("potassium:chloride symporter activity")|go:"GO:0015696"|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043583"(ear development)|go:"GO:0048798"(swim bladder inflation)|go:"GO:0055064"(chloride ion homeostasis)|go:"GO:0055075"(potassium ion homeostasis)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR002443(Na-K-Cl co-transporter)|interpro:IPR002444(Na-K-Cl co-transporter 1)|interpro:IPR004841(Amino acid permease-associated region)|interpro:IPR004842(Na-K-Cl cotransporter superfamily)|interpro:IPR013612(Amino acid permease N-terminal)|interpro:IPR018491|rcsb pdb:6NPH|rcsb pdb:6NPJ|rcsb pdb:6NPK|rcsb pdb:6NPL|reactome:R-DRE-426117|refseq:NP_001002080.1|refseq:NP_001157126.1	-	-	-	figure legend:Fig 1, Extended Data Fig 2, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/06/12	2020/12/11	rogid:StGyX1f0/RnC5mIbRPjBbbp3saU7955	rogid:StGyX1f0/RnC5mIbRPjBbbp3saU7955	rigid:YRXl2LY5nRr4clEl0QPYR3Na0Js	false	-	-	2	0	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)