#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q92743-PRO_0000026943	uniprotkb:Q15582-PRO_0000008769	intact:EBI-25467104	intact:EBI-25467097	psi-mi:q92743-pro_0000026943(display_long)|uniprotkb:HTRA1(gene name)|psi-mi:HTRA1(display_short)|uniprotkb:HTRA(gene name synonym)|uniprotkb:PRSS11(gene name synonym)|uniprotkb:High-temperature requirement A serine peptidase 1(gene name synonym)|uniprotkb:L56(gene name synonym)|uniprotkb:Serine protease 11(gene name synonym)	psi-mi:q15582-pro_0000008769(display_long)|uniprotkb:TGFBI(gene name)|psi-mi:TGFBI(display_short)|uniprotkb:BIGH3(gene name synonym)|uniprotkb:Kerato-epithelin(gene name synonym)|uniprotkb:RGD-containing collagen-associated protein(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Poulsen et al. (2019)	pubmed:31197037|imex:IM-27776	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25467095|imex:IM-27776-1	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-352256(chain-parent)	intact:EBI-10236573(chain-parent)	go:"GO:0004252"(serine-type endopeptidase activity)	chain-seq-start:23|chain-seq-end:480	chain-seq-start:24|chain-seq-end:683	figure legend:1B/C/D|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/05	2020/03/09	rogid:HFe6T+Xv4bxKh2Y71yb81xsOX3g9606	rogid:jUjaG/t8pEZNp11wzAGN7bWFSXY9606	rigid:hprTwA5rxq3T9tcc4zMz/Nsf66M	false	-	sufficient binding region:1-646|mutation with no effect:101-101|mutation with no effect:532-532|mutation with no effect:523-523,528-528|mutation increasing interaction rate:101-101|mutation increasing interaction rate:523-523|mutation increasing interaction rate:523-523|mutation increasing interaction rate:101-101	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)|psi-mi:"MI:0113"(western blot)
uniprotkb:Q92743-PRO_0000026943	uniprotkb:Q15582	intact:EBI-25467104	intact:EBI-10236573|uniprotkb:D3DQB1|uniprotkb:O43218|uniprotkb:O43217|uniprotkb:O14476|uniprotkb:O14472|uniprotkb:O43216|uniprotkb:O43219|uniprotkb:Q53XM1|uniprotkb:O14471|ensembl:ENSP00000416330	psi-mi:q92743-pro_0000026943(display_long)|uniprotkb:HTRA1(gene name)|psi-mi:HTRA1(display_short)|uniprotkb:HTRA(gene name synonym)|uniprotkb:PRSS11(gene name synonym)|uniprotkb:High-temperature requirement A serine peptidase 1(gene name synonym)|uniprotkb:L56(gene name synonym)|uniprotkb:Serine protease 11(gene name synonym)	psi-mi:bgh3_human(display_long)|uniprotkb:TGFBI(gene name)|psi-mi:TGFBI(display_short)|uniprotkb:BIGH3(gene name synonym)|uniprotkb:Kerato-epithelin(gene name synonym)|uniprotkb:RGD-containing collagen-associated protein(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Poulsen et al. (2019)	pubmed:31197037|imex:IM-27776	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25467175|imex:IM-27776-3	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-352256(chain-parent)	refseq:NP_000349.1|interpro:IPR032954|interpro:IPR036378|rcsb pdb:1X3B|rcsb pdb:2LTB|rcsb pdb:2LTC|rcsb pdb:2VXP|rcsb pdb:5NV6|rcsb pdb:7AS7|rcsb pdb:7ASC|rcsb pdb:7ASG|reactome:R-HSA-977225|ensembl:ENSG00000120708(gene)|ensembl:ENST00000442011(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007601"(visual perception)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042802"(identical protein binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050896"(response to stimulus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000782(Beta-Ig-H3/fasciclin)|interpro:IPR011489(EMI)|interpro:IPR016666(TGF beta-induced protein bIGH3/osteoblast-specific factor 2)	go:"GO:0004252"(serine-type endopeptidase activity)	chain-seq-start:23|chain-seq-end:480	-	figure legend:2,3|comment:MS  mapping of HtrA1 cleavage sites showed that the  mutants underwent extensive cleavage in several regions.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/05	2020/03/09	rogid:HFe6T+Xv4bxKh2Y71yb81xsOX3g9606	rogid:86Kh2QpWO6GxkrQsjbtqcBrKs4M9606	rigid:Kx+Yo2D/sFclkVC2Py3cYuPV2NA	false	-	sufficient binding region:502-657|mutation with no effect:555-555|mutation increasing interaction rate:546-546,551-551|mutation with no effect:555-555|mutation increasing interaction rate:546-546|his tag:n-n|mutation increasing interaction rate:546-546|mutation increasing interaction rate:624-624	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0102"(sequence tag identification)|psi-mi:"MI:0113"(western blot)
uniprotkb:Q15582	uniprotkb:Q15582	intact:EBI-10236573|uniprotkb:D3DQB1|uniprotkb:O43218|uniprotkb:O43217|uniprotkb:O14476|uniprotkb:O14472|uniprotkb:O43216|uniprotkb:O43219|uniprotkb:Q53XM1|uniprotkb:O14471|ensembl:ENSP00000416330	intact:EBI-10236573|uniprotkb:D3DQB1|uniprotkb:O43218|uniprotkb:O43217|uniprotkb:O14476|uniprotkb:O14472|uniprotkb:O43216|uniprotkb:O43219|uniprotkb:Q53XM1|uniprotkb:O14471|ensembl:ENSP00000416330	psi-mi:bgh3_human(display_long)|uniprotkb:TGFBI(gene name)|psi-mi:TGFBI(display_short)|uniprotkb:BIGH3(gene name synonym)|uniprotkb:Kerato-epithelin(gene name synonym)|uniprotkb:RGD-containing collagen-associated protein(gene name synonym)	psi-mi:bgh3_human(display_long)|uniprotkb:TGFBI(gene name)|psi-mi:TGFBI(display_short)|uniprotkb:BIGH3(gene name synonym)|uniprotkb:Kerato-epithelin(gene name synonym)|uniprotkb:RGD-containing collagen-associated protein(gene name synonym)	psi-mi:"MI:1232"(aggregation assay)	Poulsen et al. (2019)	pubmed:31197037|imex:IM-27776	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25467278|imex:IM-27776-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000349.1|interpro:IPR032954|interpro:IPR036378|rcsb pdb:1X3B|rcsb pdb:2LTB|rcsb pdb:2LTC|rcsb pdb:2VXP|rcsb pdb:5NV6|rcsb pdb:7AS7|rcsb pdb:7ASC|rcsb pdb:7ASG|reactome:R-HSA-977225|ensembl:ENSG00000120708(gene)|ensembl:ENST00000442011(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007601"(visual perception)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042802"(identical protein binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050896"(response to stimulus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000782(Beta-Ig-H3/fasciclin)|interpro:IPR011489(EMI)|interpro:IPR016666(TGF beta-induced protein bIGH3/osteoblast-specific factor 2)	refseq:NP_000349.1|interpro:IPR032954|interpro:IPR036378|rcsb pdb:1X3B|rcsb pdb:2LTB|rcsb pdb:2LTC|rcsb pdb:2VXP|rcsb pdb:5NV6|rcsb pdb:7AS7|rcsb pdb:7ASC|rcsb pdb:7ASG|reactome:R-HSA-977225|ensembl:ENSG00000120708(gene)|ensembl:ENST00000442011(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007601"(visual perception)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042802"(identical protein binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050896"(response to stimulus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000782(Beta-Ig-H3/fasciclin)|interpro:IPR011489(EMI)|interpro:IPR016666(TGF beta-induced protein bIGH3/osteoblast-specific factor 2)	-	-	-	figure legend:4|comment:Peptide content >~10% in pellet.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/05	2020/03/10	rogid:86Kh2QpWO6GxkrQsjbtqcBrKs4M9606	rogid:86Kh2QpWO6GxkrQsjbtqcBrKs4M9606	rigid:esE3ytbG+w0XsIA9dsA4u+IAHU0	false	binding-associated region:560-589|binding-associated region:560-569|sufficient binding region:502-657|mutation:546-546,551-551|mutation:546-546|his tag:n-n|mutation:546-546|mutation:624-624	binding-associated region:560-589|binding-associated region:560-569|sufficient binding region:502-657|mutation:546-546,551-551|mutation:546-546|his tag:n-n|mutation:546-546|mutation:624-624	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15582	uniprotkb:Q15582	intact:EBI-10236573|uniprotkb:D3DQB1|uniprotkb:O43218|uniprotkb:O43217|uniprotkb:O14476|uniprotkb:O14472|uniprotkb:O43216|uniprotkb:O43219|uniprotkb:Q53XM1|uniprotkb:O14471|ensembl:ENSP00000416330	intact:EBI-10236573|uniprotkb:D3DQB1|uniprotkb:O43218|uniprotkb:O43217|uniprotkb:O14476|uniprotkb:O14472|uniprotkb:O43216|uniprotkb:O43219|uniprotkb:Q53XM1|uniprotkb:O14471|ensembl:ENSP00000416330	psi-mi:bgh3_human(display_long)|uniprotkb:TGFBI(gene name)|psi-mi:TGFBI(display_short)|uniprotkb:BIGH3(gene name synonym)|uniprotkb:Kerato-epithelin(gene name synonym)|uniprotkb:RGD-containing collagen-associated protein(gene name synonym)	psi-mi:bgh3_human(display_long)|uniprotkb:TGFBI(gene name)|psi-mi:TGFBI(display_short)|uniprotkb:BIGH3(gene name synonym)|uniprotkb:Kerato-epithelin(gene name synonym)|uniprotkb:RGD-containing collagen-associated protein(gene name synonym)	psi-mi:"MI:1232"(aggregation assay)	Poulsen et al. (2019)	pubmed:31197037|imex:IM-27776	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25467351|imex:IM-27776-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000349.1|interpro:IPR032954|interpro:IPR036378|rcsb pdb:1X3B|rcsb pdb:2LTB|rcsb pdb:2LTC|rcsb pdb:2VXP|rcsb pdb:5NV6|rcsb pdb:7AS7|rcsb pdb:7ASC|rcsb pdb:7ASG|reactome:R-HSA-977225|ensembl:ENSG00000120708(gene)|ensembl:ENST00000442011(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007601"(visual perception)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042802"(identical protein binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050896"(response to stimulus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000782(Beta-Ig-H3/fasciclin)|interpro:IPR011489(EMI)|interpro:IPR016666(TGF beta-induced protein bIGH3/osteoblast-specific factor 2)	refseq:NP_000349.1|interpro:IPR032954|interpro:IPR036378|rcsb pdb:1X3B|rcsb pdb:2LTB|rcsb pdb:2LTC|rcsb pdb:2VXP|rcsb pdb:5NV6|rcsb pdb:7AS7|rcsb pdb:7ASC|rcsb pdb:7ASG|reactome:R-HSA-977225|ensembl:ENSG00000120708(gene)|ensembl:ENST00000442011(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007601"(visual perception)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042802"(identical protein binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050896"(response to stimulus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000782(Beta-Ig-H3/fasciclin)|interpro:IPR011489(EMI)|interpro:IPR016666(TGF beta-induced protein bIGH3/osteoblast-specific factor 2)	-	-	-	figure legend:4|comment:Interactions in supernatant.  Some  supernatant fibril formation was seen for all mutants tested, but not to  such a great extent as seen in the pellets.  The highest peptide counts were seen outside the Gly-560–Leu-589 region.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/05	2020/03/10	rogid:86Kh2QpWO6GxkrQsjbtqcBrKs4M9606	rogid:86Kh2QpWO6GxkrQsjbtqcBrKs4M9606	rigid:esE3ytbG+w0XsIA9dsA4u+IAHU0	false	sufficient binding region:502-657|mutation:546-546,551-551|mutation:546-546|his tag:n-n|mutation:546-546|mutation:624-624	sufficient binding region:502-657|mutation:546-546,551-551|mutation:546-546|his tag:n-n|mutation:546-546|mutation:624-624	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15582	uniprotkb:Q15582	intact:EBI-10236573|uniprotkb:D3DQB1|uniprotkb:O43218|uniprotkb:O43217|uniprotkb:O14476|uniprotkb:O14472|uniprotkb:O43216|uniprotkb:O43219|uniprotkb:Q53XM1|uniprotkb:O14471|ensembl:ENSP00000416330	intact:EBI-10236573|uniprotkb:D3DQB1|uniprotkb:O43218|uniprotkb:O43217|uniprotkb:O14476|uniprotkb:O14472|uniprotkb:O43216|uniprotkb:O43219|uniprotkb:Q53XM1|uniprotkb:O14471|ensembl:ENSP00000416330	psi-mi:bgh3_human(display_long)|uniprotkb:TGFBI(gene name)|psi-mi:TGFBI(display_short)|uniprotkb:BIGH3(gene name synonym)|uniprotkb:Kerato-epithelin(gene name synonym)|uniprotkb:RGD-containing collagen-associated protein(gene name synonym)	psi-mi:bgh3_human(display_long)|uniprotkb:TGFBI(gene name)|psi-mi:TGFBI(display_short)|uniprotkb:BIGH3(gene name synonym)|uniprotkb:Kerato-epithelin(gene name synonym)|uniprotkb:RGD-containing collagen-associated protein(gene name synonym)	psi-mi:"MI:1232"(aggregation assay)	Poulsen et al. (2019)	pubmed:31197037|imex:IM-27776	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25467398|imex:IM-27776-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000349.1|interpro:IPR032954|interpro:IPR036378|rcsb pdb:1X3B|rcsb pdb:2LTB|rcsb pdb:2LTC|rcsb pdb:2VXP|rcsb pdb:5NV6|rcsb pdb:7AS7|rcsb pdb:7ASC|rcsb pdb:7ASG|reactome:R-HSA-977225|ensembl:ENSG00000120708(gene)|ensembl:ENST00000442011(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007601"(visual perception)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042802"(identical protein binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050896"(response to stimulus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000782(Beta-Ig-H3/fasciclin)|interpro:IPR011489(EMI)|interpro:IPR016666(TGF beta-induced protein bIGH3/osteoblast-specific factor 2)	refseq:NP_000349.1|interpro:IPR032954|interpro:IPR036378|rcsb pdb:1X3B|rcsb pdb:2LTB|rcsb pdb:2LTC|rcsb pdb:2VXP|rcsb pdb:5NV6|rcsb pdb:7AS7|rcsb pdb:7ASC|rcsb pdb:7ASG|reactome:R-HSA-977225|ensembl:ENSG00000120708(gene)|ensembl:ENST00000442011(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007601"(visual perception)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042802"(identical protein binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050896"(response to stimulus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000782(Beta-Ig-H3/fasciclin)|interpro:IPR011489(EMI)|interpro:IPR016666(TGF beta-induced protein bIGH3/osteoblast-specific factor 2)	-	-	-	figure legend:5A|comment:Increased ThT fluorescence as a function of time was observed for all four LCD-linked FAS1-4 variants in the presence of HtrA1.|agonist:"HtrA1(Q92743-PRO_0000026943)"|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/05	2020/03/10	rogid:86Kh2QpWO6GxkrQsjbtqcBrKs4M9606	rogid:86Kh2QpWO6GxkrQsjbtqcBrKs4M9606	rigid:esE3ytbG+w0XsIA9dsA4u+IAHU0	false	sufficient binding region:502-657|mutation:546-546,551-551|mutation:546-546|his tag:n-n|mutation:546-546|mutation:624-624	sufficient binding region:502-657|mutation:546-546,551-551|mutation:546-546|his tag:n-n|mutation:546-546|mutation:624-624	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15582	uniprotkb:Q15582	intact:EBI-10236573|uniprotkb:D3DQB1|uniprotkb:O43218|uniprotkb:O43217|uniprotkb:O14476|uniprotkb:O14472|uniprotkb:O43216|uniprotkb:O43219|uniprotkb:Q53XM1|uniprotkb:O14471|ensembl:ENSP00000416330	intact:EBI-10236573|uniprotkb:D3DQB1|uniprotkb:O43218|uniprotkb:O43217|uniprotkb:O14476|uniprotkb:O14472|uniprotkb:O43216|uniprotkb:O43219|uniprotkb:Q53XM1|uniprotkb:O14471|ensembl:ENSP00000416330	psi-mi:bgh3_human(display_long)|uniprotkb:TGFBI(gene name)|psi-mi:TGFBI(display_short)|uniprotkb:BIGH3(gene name synonym)|uniprotkb:Kerato-epithelin(gene name synonym)|uniprotkb:RGD-containing collagen-associated protein(gene name synonym)	psi-mi:bgh3_human(display_long)|uniprotkb:TGFBI(gene name)|psi-mi:TGFBI(display_short)|uniprotkb:BIGH3(gene name synonym)|uniprotkb:Kerato-epithelin(gene name synonym)|uniprotkb:RGD-containing collagen-associated protein(gene name synonym)	psi-mi:"MI:0964"(infrared spectroscopy)	Poulsen et al. (2019)	pubmed:31197037|imex:IM-27776	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25467470|imex:IM-27776-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000349.1|interpro:IPR032954|interpro:IPR036378|rcsb pdb:1X3B|rcsb pdb:2LTB|rcsb pdb:2LTC|rcsb pdb:2VXP|rcsb pdb:5NV6|rcsb pdb:7AS7|rcsb pdb:7ASC|rcsb pdb:7ASG|reactome:R-HSA-977225|ensembl:ENSG00000120708(gene)|ensembl:ENST00000442011(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007601"(visual perception)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042802"(identical protein binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050896"(response to stimulus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000782(Beta-Ig-H3/fasciclin)|interpro:IPR011489(EMI)|interpro:IPR016666(TGF beta-induced protein bIGH3/osteoblast-specific factor 2)	refseq:NP_000349.1|interpro:IPR032954|interpro:IPR036378|rcsb pdb:1X3B|rcsb pdb:2LTB|rcsb pdb:2LTC|rcsb pdb:2VXP|rcsb pdb:5NV6|rcsb pdb:7AS7|rcsb pdb:7ASC|rcsb pdb:7ASG|reactome:R-HSA-977225|ensembl:ENSG00000120708(gene)|ensembl:ENST00000442011(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007601"(visual perception)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042802"(identical protein binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050896"(response to stimulus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000782(Beta-Ig-H3/fasciclin)|interpro:IPR011489(EMI)|interpro:IPR016666(TGF beta-induced protein bIGH3/osteoblast-specific factor 2)	-	-	-	figure legend:5B|comment:A shift for the undigested FAS1-4 mutants from 1651-1653 cm-1 to 1627-1630 cm-1, was shown after incubation with HtrA1;values characteristic of beta-sheet and beta-amyloid-sheet formation.|agonist:"HtrA1(Q92743-PRO_0000026943)"|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/05	2020/03/10	rogid:86Kh2QpWO6GxkrQsjbtqcBrKs4M9606	rogid:86Kh2QpWO6GxkrQsjbtqcBrKs4M9606	rigid:esE3ytbG+w0XsIA9dsA4u+IAHU0	false	sufficient binding region:502-657|mutation:546-546,551-551|mutation:546-546|his tag:n-n|mutation:546-546|mutation:624-624	sufficient binding region:502-657|mutation:546-546,551-551|mutation:546-546|his tag:n-n|mutation:546-546|mutation:624-624	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15582	uniprotkb:Q15582	intact:EBI-10236573|uniprotkb:D3DQB1|uniprotkb:O43218|uniprotkb:O43217|uniprotkb:O14476|uniprotkb:O14472|uniprotkb:O43216|uniprotkb:O43219|uniprotkb:Q53XM1|uniprotkb:O14471|ensembl:ENSP00000416330	intact:EBI-10236573|uniprotkb:D3DQB1|uniprotkb:O43218|uniprotkb:O43217|uniprotkb:O14476|uniprotkb:O14472|uniprotkb:O43216|uniprotkb:O43219|uniprotkb:Q53XM1|uniprotkb:O14471|ensembl:ENSP00000416330	psi-mi:bgh3_human(display_long)|uniprotkb:TGFBI(gene name)|psi-mi:TGFBI(display_short)|uniprotkb:BIGH3(gene name synonym)|uniprotkb:Kerato-epithelin(gene name synonym)|uniprotkb:RGD-containing collagen-associated protein(gene name synonym)	psi-mi:bgh3_human(display_long)|uniprotkb:TGFBI(gene name)|psi-mi:TGFBI(display_short)|uniprotkb:BIGH3(gene name synonym)|uniprotkb:Kerato-epithelin(gene name synonym)|uniprotkb:RGD-containing collagen-associated protein(gene name synonym)	psi-mi:"MI:0020"(transmission electron microscopy)	Poulsen et al. (2019)	pubmed:31197037|imex:IM-27776	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25467545|imex:IM-27776-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000349.1|interpro:IPR032954|interpro:IPR036378|rcsb pdb:1X3B|rcsb pdb:2LTB|rcsb pdb:2LTC|rcsb pdb:2VXP|rcsb pdb:5NV6|rcsb pdb:7AS7|rcsb pdb:7ASC|rcsb pdb:7ASG|reactome:R-HSA-977225|ensembl:ENSG00000120708(gene)|ensembl:ENST00000442011(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007601"(visual perception)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042802"(identical protein binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050896"(response to stimulus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000782(Beta-Ig-H3/fasciclin)|interpro:IPR011489(EMI)|interpro:IPR016666(TGF beta-induced protein bIGH3/osteoblast-specific factor 2)	refseq:NP_000349.1|interpro:IPR032954|interpro:IPR036378|rcsb pdb:1X3B|rcsb pdb:2LTB|rcsb pdb:2LTC|rcsb pdb:2VXP|rcsb pdb:5NV6|rcsb pdb:7AS7|rcsb pdb:7ASC|rcsb pdb:7ASG|reactome:R-HSA-977225|ensembl:ENSG00000120708(gene)|ensembl:ENST00000442011(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007601"(visual perception)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042802"(identical protein binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050896"(response to stimulus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000782(Beta-Ig-H3/fasciclin)|interpro:IPR011489(EMI)|interpro:IPR016666(TGF beta-induced protein bIGH3/osteoblast-specific factor 2)	-	-	-	figure legend:5C|comment:Elongated fibrils for FAS1-4 samples incubated with HtrA1were seen.Nonfibrillar aggregates were observed for nonprotease-treated FAS1-4 mutants.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/05	2020/03/10	rogid:86Kh2QpWO6GxkrQsjbtqcBrKs4M9606	rogid:86Kh2QpWO6GxkrQsjbtqcBrKs4M9606	rigid:esE3ytbG+w0XsIA9dsA4u+IAHU0	false	sufficient binding region:502-657|mutation:546-546,551-551|mutation:546-546|his tag:n-n|mutation:546-546|mutation:624-624	sufficient binding region:502-657|mutation:546-546,551-551|mutation:546-546|his tag:n-n|mutation:546-546|mutation:624-624	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)