#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B chebi:"CHEBI:15422" uniprotkb:P0C6X7-PRO_0000037319 intact:EBI-1108845|chebi:"CHEBI:40938"|chebi:"CHEBI:10841"|chebi:"CHEBI:10789"|chebi:"CHEBI:2359"|chebi:"CHEBI:13236"|chebi:"CHEBI:22249" intact:EBI-25487926 psi-mi:atp(display_short)|psi-mi:"CHEBI:15422"(display_long)|intact:Adenosine 5'-triphosphate(synonym)|intact:Adenosine triphosphate(synonym)|intact:ADENOSINE-5'-TRIPHOSPHATE(synonym)|intact:Adephos(synonym)|intact:Adetol(synonym)|intact:Adynol(synonym)|intact:Atipi(synonym)|intact:ATP(synonym)|intact:Atriphos(synonym)|intact:Cardenosine(synonym)|intact:Fosfobion(synonym)|intact:Glucobasin(synonym)|intact:H4atp(synonym)|intact:Myotriphos(synonym)|intact:Triadenyl(synonym)|intact:Triphosphaden(synonym)|intact:"adenosine 5'-(tetrahydrogen triphosphate)"(iupac name) psi-mi:p0c6x7-pro_0000037319(display_long)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)|uniprotkb:rep(gene name)|psi-mi:rep(display_short) psi-mi:"MI:0880"(atpase assay) Jia et al. (2019) imex:IM-28432|pubmed:31131400 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0882"(atpase reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26368324|imex:IM-28432-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - uniprotkb:P0C6X7(chain-parent)|intact:EBI-7843867(chain-parent) go:"GO:0016887"(ATP hydrolysis activity) - chain-seq-start:5302|chain-seq-end:5902 figure legend:1C, 2 B/C, 7 C/D|kinetics:W.T. Vmax =0.5 uM/min|kinetics:"Initial velocities for WT and mutants: 0.40 uM/s (WT-Nsp13), 0.19 uM/s (K288A), 0.19 uM/s (S289A), 0.17 uM/s (D374A), 0.18 uM/s (E375A), 0.17 uM/s (Q404A) and 0.17 uM/s (R567A)."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) km:0.16x10^-3(molar) 2020/10/06 2020/10/14 - rogid:p7KzZyyr+yMS7ZiMTBx4VVZRzGc694009 - false - mutation decreasing interaction rate:288-288|mutation decreasing interaction rate:289-289|mutation decreasing interaction rate:374-374|mutation decreasing interaction rate:375-375|mutation decreasing interaction rate:404-404|mutation decreasing interaction rate:567-567 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:15422" intact:EBI-26368363 intact:EBI-1108845|chebi:"CHEBI:40938"|chebi:"CHEBI:10841"|chebi:"CHEBI:10789"|chebi:"CHEBI:2359"|chebi:"CHEBI:13236"|chebi:"CHEBI:22249" - psi-mi:atp(display_short)|psi-mi:"CHEBI:15422"(display_long)|intact:Adenosine 5'-triphosphate(synonym)|intact:Adenosine triphosphate(synonym)|intact:ADENOSINE-5'-TRIPHOSPHATE(synonym)|intact:Adephos(synonym)|intact:Adetol(synonym)|intact:Adynol(synonym)|intact:Atipi(synonym)|intact:ATP(synonym)|intact:Atriphos(synonym)|intact:Cardenosine(synonym)|intact:Fosfobion(synonym)|intact:Glucobasin(synonym)|intact:H4atp(synonym)|intact:Myotriphos(synonym)|intact:Triadenyl(synonym)|intact:Triphosphaden(synonym)|intact:"adenosine 5'-(tetrahydrogen triphosphate)"(iupac name) psi-mi:ssdna_dt25(display_short)|psi-mi:EBI-26368363(display_long) psi-mi:"MI:0880"(atpase assay) Jia et al. (2019) imex:IM-28432|pubmed:31131400 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:32630(synthetic construct)|taxid:32630(synthetic construct) psi-mi:"MI:0882"(atpase reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26368324|imex:IM-28432-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) - - go:"GO:0016887"(ATP hydrolysis activity) - - figure legend:1C, 2 B/C, 7 C/D|kinetics:W.T. Vmax =0.5 uM/min|kinetics:"Initial velocities for WT and mutants: 0.40 uM/s (WT-Nsp13), 0.19 uM/s (K288A), 0.19 uM/s (S289A), 0.17 uM/s (D374A), 0.18 uM/s (E375A), 0.17 uM/s (Q404A) and 0.17 uM/s (R567A)."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) km:0.16x10^-3(molar) 2020/10/06 2020/10/14 - - - false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:15422" uniprotkb:P0C6X7-PRO_0000037318 intact:EBI-1108845|chebi:"CHEBI:40938"|chebi:"CHEBI:10841"|chebi:"CHEBI:10789"|chebi:"CHEBI:2359"|chebi:"CHEBI:13236"|chebi:"CHEBI:22249" intact:EBI-25487684 psi-mi:atp(display_short)|psi-mi:"CHEBI:15422"(display_long)|intact:Adenosine 5'-triphosphate(synonym)|intact:Adenosine triphosphate(synonym)|intact:ADENOSINE-5'-TRIPHOSPHATE(synonym)|intact:Adephos(synonym)|intact:Adetol(synonym)|intact:Adynol(synonym)|intact:Atipi(synonym)|intact:ATP(synonym)|intact:Atriphos(synonym)|intact:Cardenosine(synonym)|intact:Fosfobion(synonym)|intact:Glucobasin(synonym)|intact:H4atp(synonym)|intact:Myotriphos(synonym)|intact:Triadenyl(synonym)|intact:Triphosphaden(synonym)|intact:"adenosine 5'-(tetrahydrogen triphosphate)"(iupac name) psi-mi:p0c6x7-pro_0000037318(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0880"(atpase assay) Jia et al. (2019) imex:IM-28432|pubmed:31131400 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0882"(atpase reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26368801|imex:IM-28432-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0840"(stimulator) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) go:"GO:0016887"(ATP hydrolysis activity) - chain-seq-start:4370|chain-seq-end:5301 figure legend:7 C/D|kinetics:"Reaction velocities:- 0.24uM/s (SARS-Nsp13), 0.36uM/s (SARS-Nsp13 plus SARS-Nsp12)."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/06 2020/10/15 - rogid:eeAJDsSyQ9Qfnm1xY+XJWlCGwWY694009 - false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:15422" uniprotkb:P0C6X7-PRO_0000037319 intact:EBI-1108845|chebi:"CHEBI:40938"|chebi:"CHEBI:10841"|chebi:"CHEBI:10789"|chebi:"CHEBI:2359"|chebi:"CHEBI:13236"|chebi:"CHEBI:22249" intact:EBI-25487926 psi-mi:atp(display_short)|psi-mi:"CHEBI:15422"(display_long)|intact:Adenosine 5'-triphosphate(synonym)|intact:Adenosine triphosphate(synonym)|intact:ADENOSINE-5'-TRIPHOSPHATE(synonym)|intact:Adephos(synonym)|intact:Adetol(synonym)|intact:Adynol(synonym)|intact:Atipi(synonym)|intact:ATP(synonym)|intact:Atriphos(synonym)|intact:Cardenosine(synonym)|intact:Fosfobion(synonym)|intact:Glucobasin(synonym)|intact:H4atp(synonym)|intact:Myotriphos(synonym)|intact:Triadenyl(synonym)|intact:Triphosphaden(synonym)|intact:"adenosine 5'-(tetrahydrogen triphosphate)"(iupac name) psi-mi:p0c6x7-pro_0000037319(display_long)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)|uniprotkb:rep(gene name)|psi-mi:rep(display_short) psi-mi:"MI:0880"(atpase assay) Jia et al. (2019) imex:IM-28432|pubmed:31131400 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0882"(atpase reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26368801|imex:IM-28432-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - uniprotkb:P0C6X7(chain-parent)|intact:EBI-7843867(chain-parent) go:"GO:0016887"(ATP hydrolysis activity) - chain-seq-start:5302|chain-seq-end:5902 figure legend:7 C/D|kinetics:"Reaction velocities:- 0.24uM/s (SARS-Nsp13), 0.36uM/s (SARS-Nsp13 plus SARS-Nsp12)."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/06 2020/10/15 - rogid:p7KzZyyr+yMS7ZiMTBx4VVZRzGc694009 - false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:15422" intact:EBI-26368363 intact:EBI-1108845|chebi:"CHEBI:40938"|chebi:"CHEBI:10841"|chebi:"CHEBI:10789"|chebi:"CHEBI:2359"|chebi:"CHEBI:13236"|chebi:"CHEBI:22249" - psi-mi:atp(display_short)|psi-mi:"CHEBI:15422"(display_long)|intact:Adenosine 5'-triphosphate(synonym)|intact:Adenosine triphosphate(synonym)|intact:ADENOSINE-5'-TRIPHOSPHATE(synonym)|intact:Adephos(synonym)|intact:Adetol(synonym)|intact:Adynol(synonym)|intact:Atipi(synonym)|intact:ATP(synonym)|intact:Atriphos(synonym)|intact:Cardenosine(synonym)|intact:Fosfobion(synonym)|intact:Glucobasin(synonym)|intact:H4atp(synonym)|intact:Myotriphos(synonym)|intact:Triadenyl(synonym)|intact:Triphosphaden(synonym)|intact:"adenosine 5'-(tetrahydrogen triphosphate)"(iupac name) psi-mi:ssdna_dt25(display_short)|psi-mi:EBI-26368363(display_long) psi-mi:"MI:0880"(atpase assay) Jia et al. (2019) imex:IM-28432|pubmed:31131400 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:32630(synthetic construct)|taxid:32630(synthetic construct) psi-mi:"MI:0882"(atpase reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26368801|imex:IM-28432-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) - - go:"GO:0016887"(ATP hydrolysis activity) - - figure legend:7 C/D|kinetics:"Reaction velocities:- 0.24uM/s (SARS-Nsp13), 0.36uM/s (SARS-Nsp13 plus SARS-Nsp12)."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/06 2020/10/15 - - - false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:15422" uniprotkb:K9N7C7-PRO_0000422449 intact:EBI-1108845|chebi:"CHEBI:40938"|chebi:"CHEBI:10841"|chebi:"CHEBI:10789"|chebi:"CHEBI:2359"|chebi:"CHEBI:13236"|chebi:"CHEBI:22249" intact:EBI-25592936 psi-mi:atp(display_short)|psi-mi:"CHEBI:15422"(display_long)|intact:Adenosine 5'-triphosphate(synonym)|intact:Adenosine triphosphate(synonym)|intact:ADENOSINE-5'-TRIPHOSPHATE(synonym)|intact:Adephos(synonym)|intact:Adetol(synonym)|intact:Adynol(synonym)|intact:Atipi(synonym)|intact:ATP(synonym)|intact:Atriphos(synonym)|intact:Cardenosine(synonym)|intact:Fosfobion(synonym)|intact:Glucobasin(synonym)|intact:H4atp(synonym)|intact:Myotriphos(synonym)|intact:Triadenyl(synonym)|intact:Triphosphaden(synonym)|intact:"adenosine 5'-(tetrahydrogen triphosphate)"(iupac name) psi-mi:k9n7c7-pro_0000422449(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0880"(atpase assay) Jia et al. (2019) imex:IM-28432|pubmed:31131400 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:1263720(cvemc)|taxid:1263720("Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1)") psi-mi:"MI:0882"(atpase reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26368823|imex:IM-28432-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0840"(stimulator) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - intact:EBI-25591996(chain-parent) go:"GO:0016887"(ATP hydrolysis activity) - chain-seq-start:4378|chain-seq-end:5310 figure legend:7 C/D|kinetics:"Reaction velocities:- 0.24uM/s (SARS-Nsp13), 0.34uM/s (SARS-Nsp13 plus MERS-Nsp12)."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/06 2020/10/15 - rogid:C5+/nhcjhqNFlNoEsBiCA2yxafo1263720 - false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:15422" uniprotkb:P0C6X7-PRO_0000037319 intact:EBI-1108845|chebi:"CHEBI:40938"|chebi:"CHEBI:10841"|chebi:"CHEBI:10789"|chebi:"CHEBI:2359"|chebi:"CHEBI:13236"|chebi:"CHEBI:22249" intact:EBI-25487926 psi-mi:atp(display_short)|psi-mi:"CHEBI:15422"(display_long)|intact:Adenosine 5'-triphosphate(synonym)|intact:Adenosine triphosphate(synonym)|intact:ADENOSINE-5'-TRIPHOSPHATE(synonym)|intact:Adephos(synonym)|intact:Adetol(synonym)|intact:Adynol(synonym)|intact:Atipi(synonym)|intact:ATP(synonym)|intact:Atriphos(synonym)|intact:Cardenosine(synonym)|intact:Fosfobion(synonym)|intact:Glucobasin(synonym)|intact:H4atp(synonym)|intact:Myotriphos(synonym)|intact:Triadenyl(synonym)|intact:Triphosphaden(synonym)|intact:"adenosine 5'-(tetrahydrogen triphosphate)"(iupac name) psi-mi:p0c6x7-pro_0000037319(display_long)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)|uniprotkb:rep(gene name)|psi-mi:rep(display_short) psi-mi:"MI:0880"(atpase assay) Jia et al. (2019) imex:IM-28432|pubmed:31131400 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0882"(atpase reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26368823|imex:IM-28432-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - uniprotkb:P0C6X7(chain-parent)|intact:EBI-7843867(chain-parent) go:"GO:0016887"(ATP hydrolysis activity) - chain-seq-start:5302|chain-seq-end:5902 figure legend:7 C/D|kinetics:"Reaction velocities:- 0.24uM/s (SARS-Nsp13), 0.34uM/s (SARS-Nsp13 plus MERS-Nsp12)."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/06 2020/10/15 - rogid:p7KzZyyr+yMS7ZiMTBx4VVZRzGc694009 - false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:15422" intact:EBI-26368363 intact:EBI-1108845|chebi:"CHEBI:40938"|chebi:"CHEBI:10841"|chebi:"CHEBI:10789"|chebi:"CHEBI:2359"|chebi:"CHEBI:13236"|chebi:"CHEBI:22249" - psi-mi:atp(display_short)|psi-mi:"CHEBI:15422"(display_long)|intact:Adenosine 5'-triphosphate(synonym)|intact:Adenosine triphosphate(synonym)|intact:ADENOSINE-5'-TRIPHOSPHATE(synonym)|intact:Adephos(synonym)|intact:Adetol(synonym)|intact:Adynol(synonym)|intact:Atipi(synonym)|intact:ATP(synonym)|intact:Atriphos(synonym)|intact:Cardenosine(synonym)|intact:Fosfobion(synonym)|intact:Glucobasin(synonym)|intact:H4atp(synonym)|intact:Myotriphos(synonym)|intact:Triadenyl(synonym)|intact:Triphosphaden(synonym)|intact:"adenosine 5'-(tetrahydrogen triphosphate)"(iupac name) psi-mi:ssdna_dt25(display_short)|psi-mi:EBI-26368363(display_long) psi-mi:"MI:0880"(atpase assay) Jia et al. (2019) imex:IM-28432|pubmed:31131400 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:32630(synthetic construct)|taxid:32630(synthetic construct) psi-mi:"MI:0882"(atpase reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26368823|imex:IM-28432-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) - - go:"GO:0016887"(ATP hydrolysis activity) - - figure legend:7 C/D|kinetics:"Reaction velocities:- 0.24uM/s (SARS-Nsp13), 0.34uM/s (SARS-Nsp13 plus MERS-Nsp12)."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/06 2020/10/15 - - - false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-26368433 intact:EBI-26368437 - - psi-mi:5'-3' long strand dna_1(display_short)|psi-mi:EBI-26368433(display_long) psi-mi:5'-3' short strand dna(display_short)|psi-mi:EBI-26368437(display_long) psi-mi:"MI:0415"(enzymatic study) Jia et al. (2019) imex:IM-28432|pubmed:31131400 taxid:32630(synthetic construct)|taxid:32630(synthetic construct) taxid:32630(synthetic construct)|taxid:32630(synthetic construct) psi-mi:"MI:0414"(enzymatic reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26368418|imex:IM-28432-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) - - go:"GO:0004386"(helicase activity) - - figure legend:1D|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/06 2020/10/14 - - - false sufficient binding region:1-30 sufficient binding region:1-15|cy3 label:15-15 - - psi-mi:"MI:0815"(confirmation by molecular weight) psi-mi:"MI:0815"(confirmation by molecular weight) chebi:"CHEBI:15422" intact:EBI-26368433 intact:EBI-1108845|chebi:"CHEBI:40938"|chebi:"CHEBI:10841"|chebi:"CHEBI:10789"|chebi:"CHEBI:2359"|chebi:"CHEBI:13236"|chebi:"CHEBI:22249" - psi-mi:atp(display_short)|psi-mi:"CHEBI:15422"(display_long)|intact:Adenosine 5'-triphosphate(synonym)|intact:Adenosine triphosphate(synonym)|intact:ADENOSINE-5'-TRIPHOSPHATE(synonym)|intact:Adephos(synonym)|intact:Adetol(synonym)|intact:Adynol(synonym)|intact:Atipi(synonym)|intact:ATP(synonym)|intact:Atriphos(synonym)|intact:Cardenosine(synonym)|intact:Fosfobion(synonym)|intact:Glucobasin(synonym)|intact:H4atp(synonym)|intact:Myotriphos(synonym)|intact:Triadenyl(synonym)|intact:Triphosphaden(synonym)|intact:"adenosine 5'-(tetrahydrogen triphosphate)"(iupac name) psi-mi:5'-3' long strand dna_1(display_short)|psi-mi:EBI-26368433(display_long) psi-mi:"MI:0415"(enzymatic study) Jia et al. (2019) imex:IM-28432|pubmed:31131400 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:32630(synthetic construct)|taxid:32630(synthetic construct) psi-mi:"MI:0414"(enzymatic reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26368418|imex:IM-28432-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) - - go:"GO:0004386"(helicase activity) - - figure legend:1D|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/06 2020/10/14 - - - false - sufficient binding region:1-30 - - psi-mi:"MI:0815"(confirmation by molecular weight) psi-mi:"MI:0815"(confirmation by molecular weight) intact:EBI-26368433 uniprotkb:P0C6X7-PRO_0000037319 - intact:EBI-25487926 psi-mi:5'-3' long strand dna_1(display_short)|psi-mi:EBI-26368433(display_long) psi-mi:p0c6x7-pro_0000037319(display_long)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)|uniprotkb:rep(gene name)|psi-mi:rep(display_short) psi-mi:"MI:0415"(enzymatic study) Jia et al. (2019) imex:IM-28432|pubmed:31131400 taxid:32630(synthetic construct)|taxid:32630(synthetic construct) taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0414"(enzymatic reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26368418|imex:IM-28432-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) psi-mi:"MI:0326"(protein) - uniprotkb:P0C6X7(chain-parent)|intact:EBI-7843867(chain-parent) go:"GO:0004386"(helicase activity) - chain-seq-start:5302|chain-seq-end:5902 figure legend:1D|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/06 2020/10/14 - rogid:p7KzZyyr+yMS7ZiMTBx4VVZRzGc694009 - false sufficient binding region:1-30 - - - psi-mi:"MI:0815"(confirmation by molecular weight) psi-mi:"MI:0815"(confirmation by molecular weight) uniprotkb:P0C6X7-PRO_0000037319 intact:EBI-26368363 intact:EBI-25487926 - psi-mi:p0c6x7-pro_0000037319(display_long)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)|uniprotkb:rep(gene name)|psi-mi:rep(display_short) psi-mi:ssdna_dt25(display_short)|psi-mi:EBI-26368363(display_long) psi-mi:"MI:0944"(mass spectrometry study of hydrogen/deuterium exchange) Jia et al. (2019) imex:IM-28432|pubmed:31131400 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:32630(synthetic construct)|taxid:32630(synthetic construct) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26368855|imex:IM-28432-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) uniprotkb:P0C6X7(chain-parent)|intact:EBI-7843867(chain-parent) - go:"GO:0016887"(ATP hydrolysis activity) chain-seq-start:5302|chain-seq-end:5902 - figure legend:Supp. figure 4|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/06 2020/11/02 rogid:p7KzZyyr+yMS7ZiMTBx4VVZRzGc694009 - - false binding-associated region:166-184|binding-associated region:512-543|binding-associated region:547-574|binding-associated region:318-342 - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P0C6X7-PRO_0000037319 uniprotkb:P0C6X7-PRO_0000037318 intact:EBI-25487926 intact:EBI-25487684 psi-mi:p0c6x7-pro_0000037319(display_long)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)|uniprotkb:rep(gene name)|psi-mi:rep(display_short) psi-mi:p0c6x7-pro_0000037318(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0944"(mass spectrometry study of hydrogen/deuterium exchange) Jia et al. (2019) imex:IM-28432|pubmed:31131400 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26368887|imex:IM-28432-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:P0C6X7(chain-parent)|intact:EBI-7843867(chain-parent) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) go:"GO:0016887"(ATP hydrolysis activity) chain-seq-start:5302|chain-seq-end:5902 chain-seq-start:4370|chain-seq-end:5301 figure legend:Supp. figure 7|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/06 2020/11/02 rogid:p7KzZyyr+yMS7ZiMTBx4VVZRzGc694009 rogid:eeAJDsSyQ9Qfnm1xY+XJWlCGwWY694009 rigid:ocDGj5PLjZzRq/lEGJi27smtVIE false binding-associated region:71-92|binding-associated region:44-56|binding-associated region:262-294|binding-associated region:317-330 - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) intact:EBI-26368486 intact:EBI-26368437 - - psi-mi:5'-3' long strand dna_2(display_short)|psi-mi:EBI-26368486(display_long) psi-mi:5'-3' short strand dna(display_short)|psi-mi:EBI-26368437(display_long) psi-mi:"MI:0415"(enzymatic study) Jia et al. (2019) imex:IM-28432|pubmed:31131400 taxid:32630(synthetic construct)|taxid:32630(synthetic construct) taxid:32630(synthetic construct)|taxid:32630(synthetic construct) psi-mi:"MI:0414"(enzymatic reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26368472|imex:IM-28432-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) - - go:"GO:0004386"(helicase activity) - - figure legend:2 D-G, Supp. figure 3|comment:The initial dsDNA concentration was 250 nM.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/06 2020/10/14 - - - false sufficient binding region:1-31|dye label:31-31 sufficient binding region:1-15|cy3 label:1-1 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) chebi:"CHEBI:15422" intact:EBI-26368486 intact:EBI-1108845|chebi:"CHEBI:40938"|chebi:"CHEBI:10841"|chebi:"CHEBI:10789"|chebi:"CHEBI:2359"|chebi:"CHEBI:13236"|chebi:"CHEBI:22249" - psi-mi:atp(display_short)|psi-mi:"CHEBI:15422"(display_long)|intact:Adenosine 5'-triphosphate(synonym)|intact:Adenosine triphosphate(synonym)|intact:ADENOSINE-5'-TRIPHOSPHATE(synonym)|intact:Adephos(synonym)|intact:Adetol(synonym)|intact:Adynol(synonym)|intact:Atipi(synonym)|intact:ATP(synonym)|intact:Atriphos(synonym)|intact:Cardenosine(synonym)|intact:Fosfobion(synonym)|intact:Glucobasin(synonym)|intact:H4atp(synonym)|intact:Myotriphos(synonym)|intact:Triadenyl(synonym)|intact:Triphosphaden(synonym)|intact:"adenosine 5'-(tetrahydrogen triphosphate)"(iupac name) psi-mi:5'-3' long strand dna_2(display_short)|psi-mi:EBI-26368486(display_long) psi-mi:"MI:0415"(enzymatic study) Jia et al. (2019) imex:IM-28432|pubmed:31131400 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:32630(synthetic construct)|taxid:32630(synthetic construct) psi-mi:"MI:0414"(enzymatic reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26368472|imex:IM-28432-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) - - go:"GO:0004386"(helicase activity) - - figure legend:2 D-G, Supp. figure 3|comment:The initial dsDNA concentration was 250 nM.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/06 2020/10/14 - - - false - sufficient binding region:1-31|dye label:31-31 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) intact:EBI-26368486 uniprotkb:P0C6X7-PRO_0000037319 - intact:EBI-25487926 psi-mi:5'-3' long strand dna_2(display_short)|psi-mi:EBI-26368486(display_long) psi-mi:p0c6x7-pro_0000037319(display_long)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)|uniprotkb:rep(gene name)|psi-mi:rep(display_short) psi-mi:"MI:0415"(enzymatic study) Jia et al. (2019) imex:IM-28432|pubmed:31131400 taxid:32630(synthetic construct)|taxid:32630(synthetic construct) taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0414"(enzymatic reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26368472|imex:IM-28432-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) psi-mi:"MI:0326"(protein) - uniprotkb:P0C6X7(chain-parent)|intact:EBI-7843867(chain-parent) go:"GO:0004386"(helicase activity) - chain-seq-start:5302|chain-seq-end:5902 figure legend:2 D-G, Supp. figure 3|comment:The initial dsDNA concentration was 250 nM.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/06 2020/10/14 - rogid:p7KzZyyr+yMS7ZiMTBx4VVZRzGc694009 - false sufficient binding region:1-31|dye label:31-31 mutation decreasing interaction rate:288-288|mutation decreasing interaction rate:289-289|mutation decreasing interaction rate:374-374|mutation decreasing interaction rate:375-375|mutation decreasing interaction rate:404-404|mutation decreasing interaction rate:567-567|mutation with no effect:442-442 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) intact:EBI-26368486 intact:EBI-26368437 - - psi-mi:5'-3' long strand dna_2(display_short)|psi-mi:EBI-26368486(display_long) psi-mi:5'-3' short strand dna(display_short)|psi-mi:EBI-26368437(display_long) psi-mi:"MI:0415"(enzymatic study) Jia et al. (2019) imex:IM-28432|pubmed:31131400 taxid:32630(synthetic construct)|taxid:32630(synthetic construct) taxid:32630(synthetic construct)|taxid:32630(synthetic construct) psi-mi:"MI:0414"(enzymatic reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26368675|imex:IM-28432-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) - - go:"GO:0004386"(helicase activity) - - figure legend:4 C/D, 6 E/F|comment:The initial dsDNA concentration was 400 nM.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/06 2020/10/15 - - - false sufficient binding region:1-31|dye label:31-31 sufficient binding region:1-15|cy3 label:1-1 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) chebi:"CHEBI:15422" intact:EBI-26368486 intact:EBI-1108845|chebi:"CHEBI:40938"|chebi:"CHEBI:10841"|chebi:"CHEBI:10789"|chebi:"CHEBI:2359"|chebi:"CHEBI:13236"|chebi:"CHEBI:22249" - psi-mi:atp(display_short)|psi-mi:"CHEBI:15422"(display_long)|intact:Adenosine 5'-triphosphate(synonym)|intact:Adenosine triphosphate(synonym)|intact:ADENOSINE-5'-TRIPHOSPHATE(synonym)|intact:Adephos(synonym)|intact:Adetol(synonym)|intact:Adynol(synonym)|intact:Atipi(synonym)|intact:ATP(synonym)|intact:Atriphos(synonym)|intact:Cardenosine(synonym)|intact:Fosfobion(synonym)|intact:Glucobasin(synonym)|intact:H4atp(synonym)|intact:Myotriphos(synonym)|intact:Triadenyl(synonym)|intact:Triphosphaden(synonym)|intact:"adenosine 5'-(tetrahydrogen triphosphate)"(iupac name) psi-mi:5'-3' long strand dna_2(display_short)|psi-mi:EBI-26368486(display_long) psi-mi:"MI:0415"(enzymatic study) Jia et al. (2019) imex:IM-28432|pubmed:31131400 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:32630(synthetic construct)|taxid:32630(synthetic construct) psi-mi:"MI:0414"(enzymatic reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26368675|imex:IM-28432-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) - - go:"GO:0004386"(helicase activity) - - figure legend:4 C/D, 6 E/F|comment:The initial dsDNA concentration was 400 nM.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/06 2020/10/15 - - - false - sufficient binding region:1-31|dye label:31-31 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) intact:EBI-26368486 uniprotkb:P0C6X7-PRO_0000037319 - intact:EBI-25487926 psi-mi:5'-3' long strand dna_2(display_short)|psi-mi:EBI-26368486(display_long) psi-mi:p0c6x7-pro_0000037319(display_long)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)|uniprotkb:rep(gene name)|psi-mi:rep(display_short) psi-mi:"MI:0415"(enzymatic study) Jia et al. (2019) imex:IM-28432|pubmed:31131400 taxid:32630(synthetic construct)|taxid:32630(synthetic construct) taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0414"(enzymatic reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26368675|imex:IM-28432-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) psi-mi:"MI:0326"(protein) - uniprotkb:P0C6X7(chain-parent)|intact:EBI-7843867(chain-parent) go:"GO:0004386"(helicase activity) - chain-seq-start:5302|chain-seq-end:5902 figure legend:4 C/D, 6 E/F|comment:The initial dsDNA concentration was 400 nM.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/06 2020/10/15 - rogid:p7KzZyyr+yMS7ZiMTBx4VVZRzGc694009 - false sufficient binding region:1-31|dye label:31-31 mutation decreasing interaction rate:337-337,339-339|mutation disrupting interaction rate:345-345,347-347|mutation decreasing interaction rate:507-508|mutation decreasing interaction rate:524-524,531-531|mutation decreasing interaction rate:539-539,541-541|mutation decreasing interaction rate:212-212,179-179|mutation decreasing interaction rate:102-102|mutation decreasing interaction rate:131-131 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) intact:EBI-26368486 intact:EBI-26368437 - - psi-mi:5'-3' long strand dna_2(display_short)|psi-mi:EBI-26368486(display_long) psi-mi:5'-3' short strand dna(display_short)|psi-mi:EBI-26368437(display_long) psi-mi:"MI:0415"(enzymatic study) Jia et al. (2019) imex:IM-28432|pubmed:31131400 taxid:32630(synthetic construct)|taxid:32630(synthetic construct) taxid:32630(synthetic construct)|taxid:32630(synthetic construct) psi-mi:"MI:0414"(enzymatic reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26368748|imex:IM-28432-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) - - go:"GO:0004386"(helicase activity) - - figure legend:7 A/B|comment:SARS-Nsp12 and MERS-Nsp12 can enhance the unwinding activity of SARS-Nsp13.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/06 2020/10/15 - - - false sufficient binding region:1-31|dye label:31-31 sufficient binding region:1-15|cy3 label:1-1 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) chebi:"CHEBI:15422" intact:EBI-26368486 intact:EBI-1108845|chebi:"CHEBI:40938"|chebi:"CHEBI:10841"|chebi:"CHEBI:10789"|chebi:"CHEBI:2359"|chebi:"CHEBI:13236"|chebi:"CHEBI:22249" - psi-mi:atp(display_short)|psi-mi:"CHEBI:15422"(display_long)|intact:Adenosine 5'-triphosphate(synonym)|intact:Adenosine triphosphate(synonym)|intact:ADENOSINE-5'-TRIPHOSPHATE(synonym)|intact:Adephos(synonym)|intact:Adetol(synonym)|intact:Adynol(synonym)|intact:Atipi(synonym)|intact:ATP(synonym)|intact:Atriphos(synonym)|intact:Cardenosine(synonym)|intact:Fosfobion(synonym)|intact:Glucobasin(synonym)|intact:H4atp(synonym)|intact:Myotriphos(synonym)|intact:Triadenyl(synonym)|intact:Triphosphaden(synonym)|intact:"adenosine 5'-(tetrahydrogen triphosphate)"(iupac name) psi-mi:5'-3' long strand dna_2(display_short)|psi-mi:EBI-26368486(display_long) psi-mi:"MI:0415"(enzymatic study) Jia et al. (2019) imex:IM-28432|pubmed:31131400 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:32630(synthetic construct)|taxid:32630(synthetic construct) psi-mi:"MI:0414"(enzymatic reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26368748|imex:IM-28432-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) - - go:"GO:0004386"(helicase activity) - - figure legend:7 A/B|comment:SARS-Nsp12 and MERS-Nsp12 can enhance the unwinding activity of SARS-Nsp13.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/06 2020/10/15 - - - false - sufficient binding region:1-31|dye label:31-31 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) intact:EBI-26368486 uniprotkb:P0C6X7-PRO_0000037318 - intact:EBI-25487684 psi-mi:5'-3' long strand dna_2(display_short)|psi-mi:EBI-26368486(display_long) psi-mi:p0c6x7-pro_0000037318(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0415"(enzymatic study) Jia et al. (2019) imex:IM-28432|pubmed:31131400 taxid:32630(synthetic construct)|taxid:32630(synthetic construct) taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0414"(enzymatic reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26368748|imex:IM-28432-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0840"(stimulator) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) psi-mi:"MI:0326"(protein) - intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) go:"GO:0004386"(helicase activity) - chain-seq-start:4370|chain-seq-end:5301 figure legend:7 A/B|comment:SARS-Nsp12 and MERS-Nsp12 can enhance the unwinding activity of SARS-Nsp13.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/06 2020/10/15 - rogid:eeAJDsSyQ9Qfnm1xY+XJWlCGwWY694009 - false sufficient binding region:1-31|dye label:31-31 - - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) intact:EBI-26368486 uniprotkb:P0C6X7-PRO_0000037319 - intact:EBI-25487926 psi-mi:5'-3' long strand dna_2(display_short)|psi-mi:EBI-26368486(display_long) psi-mi:p0c6x7-pro_0000037319(display_long)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)|uniprotkb:rep(gene name)|psi-mi:rep(display_short) psi-mi:"MI:0415"(enzymatic study) Jia et al. (2019) imex:IM-28432|pubmed:31131400 taxid:32630(synthetic construct)|taxid:32630(synthetic construct) taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0414"(enzymatic reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26368748|imex:IM-28432-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) psi-mi:"MI:0326"(protein) - uniprotkb:P0C6X7(chain-parent)|intact:EBI-7843867(chain-parent) go:"GO:0004386"(helicase activity) - chain-seq-start:5302|chain-seq-end:5902 figure legend:7 A/B|comment:SARS-Nsp12 and MERS-Nsp12 can enhance the unwinding activity of SARS-Nsp13.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/06 2020/10/15 - rogid:p7KzZyyr+yMS7ZiMTBx4VVZRzGc694009 - false sufficient binding region:1-31|dye label:31-31 - - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) intact:EBI-26368486 intact:EBI-26368437 - - psi-mi:5'-3' long strand dna_2(display_short)|psi-mi:EBI-26368486(display_long) psi-mi:5'-3' short strand dna(display_short)|psi-mi:EBI-26368437(display_long) psi-mi:"MI:0415"(enzymatic study) Jia et al. (2019) imex:IM-28432|pubmed:31131400 taxid:32630(synthetic construct)|taxid:32630(synthetic construct) taxid:32630(synthetic construct)|taxid:32630(synthetic construct) psi-mi:"MI:0414"(enzymatic reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26368784|imex:IM-28432-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) - - go:"GO:0004386"(helicase activity) - - figure legend:7 A/B|comment:SARS-Nsp12 and MERS-Nsp12 can enhance the unwinding activity of SARS-Nsp13.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/06 2020/10/15 - - - false sufficient binding region:1-31|dye label:31-31 sufficient binding region:1-15|cy3 label:1-1 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) chebi:"CHEBI:15422" intact:EBI-26368486 intact:EBI-1108845|chebi:"CHEBI:40938"|chebi:"CHEBI:10841"|chebi:"CHEBI:10789"|chebi:"CHEBI:2359"|chebi:"CHEBI:13236"|chebi:"CHEBI:22249" - psi-mi:atp(display_short)|psi-mi:"CHEBI:15422"(display_long)|intact:Adenosine 5'-triphosphate(synonym)|intact:Adenosine triphosphate(synonym)|intact:ADENOSINE-5'-TRIPHOSPHATE(synonym)|intact:Adephos(synonym)|intact:Adetol(synonym)|intact:Adynol(synonym)|intact:Atipi(synonym)|intact:ATP(synonym)|intact:Atriphos(synonym)|intact:Cardenosine(synonym)|intact:Fosfobion(synonym)|intact:Glucobasin(synonym)|intact:H4atp(synonym)|intact:Myotriphos(synonym)|intact:Triadenyl(synonym)|intact:Triphosphaden(synonym)|intact:"adenosine 5'-(tetrahydrogen triphosphate)"(iupac name) psi-mi:5'-3' long strand dna_2(display_short)|psi-mi:EBI-26368486(display_long) psi-mi:"MI:0415"(enzymatic study) Jia et al. (2019) imex:IM-28432|pubmed:31131400 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:32630(synthetic construct)|taxid:32630(synthetic construct) psi-mi:"MI:0414"(enzymatic reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26368784|imex:IM-28432-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) - - go:"GO:0004386"(helicase activity) - - figure legend:7 A/B|comment:SARS-Nsp12 and MERS-Nsp12 can enhance the unwinding activity of SARS-Nsp13.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/06 2020/10/15 - - - false - sufficient binding region:1-31|dye label:31-31 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) intact:EBI-26368486 uniprotkb:K9N7C7-PRO_0000422449 - intact:EBI-25592936 psi-mi:5'-3' long strand dna_2(display_short)|psi-mi:EBI-26368486(display_long) psi-mi:k9n7c7-pro_0000422449(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0415"(enzymatic study) Jia et al. (2019) imex:IM-28432|pubmed:31131400 taxid:32630(synthetic construct)|taxid:32630(synthetic construct) taxid:1263720(cvemc)|taxid:1263720("Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1)") psi-mi:"MI:0414"(enzymatic reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26368784|imex:IM-28432-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0840"(stimulator) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) psi-mi:"MI:0326"(protein) - intact:EBI-25591996(chain-parent) go:"GO:0004386"(helicase activity) - chain-seq-start:4378|chain-seq-end:5310 figure legend:7 A/B|comment:SARS-Nsp12 and MERS-Nsp12 can enhance the unwinding activity of SARS-Nsp13.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/06 2020/10/15 - rogid:C5+/nhcjhqNFlNoEsBiCA2yxafo1263720 - false sufficient binding region:1-31|dye label:31-31 - - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) intact:EBI-26368486 uniprotkb:P0C6X7-PRO_0000037319 - intact:EBI-25487926 psi-mi:5'-3' long strand dna_2(display_short)|psi-mi:EBI-26368486(display_long) psi-mi:p0c6x7-pro_0000037319(display_long)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)|uniprotkb:rep(gene name)|psi-mi:rep(display_short) psi-mi:"MI:0415"(enzymatic study) Jia et al. (2019) imex:IM-28432|pubmed:31131400 taxid:32630(synthetic construct)|taxid:32630(synthetic construct) taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0414"(enzymatic reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26368784|imex:IM-28432-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) psi-mi:"MI:0326"(protein) - uniprotkb:P0C6X7(chain-parent)|intact:EBI-7843867(chain-parent) go:"GO:0004386"(helicase activity) - chain-seq-start:5302|chain-seq-end:5902 figure legend:7 A/B|comment:SARS-Nsp12 and MERS-Nsp12 can enhance the unwinding activity of SARS-Nsp13.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/06 2020/10/15 - rogid:p7KzZyyr+yMS7ZiMTBx4VVZRzGc694009 - false sufficient binding region:1-31|dye label:31-31 - - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) intact:EBI-26368486 intact:EBI-26368437 - - psi-mi:5'-3' long strand dna_2(display_short)|psi-mi:EBI-26368486(display_long) psi-mi:5'-3' short strand dna(display_short)|psi-mi:EBI-26368437(display_long) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Jia et al. (2019) imex:IM-28432|pubmed:31131400 taxid:32630(synthetic construct)|taxid:32630(synthetic construct) taxid:32630(synthetic construct)|taxid:32630(synthetic construct) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-26441385|imex:IM-28432-24 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) - - go:"GO:0004386"(helicase activity) - - figure legend:4B|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/06 2020/11/02 - - - false sufficient binding region:1-31 sufficient binding region:1-15 - - psi-mi:"MI:0816"(molecular weight estimation by staining) psi-mi:"MI:0816"(molecular weight estimation by staining) intact:EBI-26368486 uniprotkb:P0C6X7-PRO_0000037319 - intact:EBI-25487926 psi-mi:5'-3' long strand dna_2(display_short)|psi-mi:EBI-26368486(display_long) psi-mi:p0c6x7-pro_0000037319(display_long)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)|uniprotkb:rep(gene name)|psi-mi:rep(display_short) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Jia et al. (2019) imex:IM-28432|pubmed:31131400 taxid:32630(synthetic construct)|taxid:32630(synthetic construct) taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-26441385|imex:IM-28432-24 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) psi-mi:"MI:0326"(protein) - uniprotkb:P0C6X7(chain-parent)|intact:EBI-7843867(chain-parent) go:"GO:0004386"(helicase activity) - chain-seq-start:5302|chain-seq-end:5902 figure legend:4B|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/10/06 2020/11/02 - rogid:p7KzZyyr+yMS7ZiMTBx4VVZRzGc694009 - false sufficient binding region:1-31 mutation decreasing interaction strength:179-179,212-212|mutation decreasing interaction strength:337-337,339-339|mutation decreasing interaction strength:345-345,347-347|mutation with no effect:507-508|mutation decreasing interaction strength:524-524,531-531|mutation decreasing interaction strength:539-539,541-541 - - psi-mi:"MI:0816"(molecular weight estimation by staining) psi-mi:"MI:0816"(molecular weight estimation by staining) uniprotkb:P0C6X7-PRO_0000037318 uniprotkb:P0C6X7-PRO_0000037319 intact:EBI-25487684 intact:EBI-25487926 psi-mi:p0c6x7-pro_0000037318(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:p0c6x7-pro_0000037319(display_long)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)|uniprotkb:rep(gene name)|psi-mi:rep(display_short) psi-mi:"MI:0107"(surface plasmon resonance) Jia et al. (2019) imex:IM-28432|pubmed:31131400 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26368841|imex:IM-28432-23 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) uniprotkb:P0C6X7(chain-parent)|intact:EBI-7843867(chain-parent) - chain-seq-start:4370|chain-seq-end:5301 chain-seq-start:5302|chain-seq-end:5902 figure legend:7 E|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:236.0x10^-9(molar) 2020/10/06 2020/11/02 rogid:eeAJDsSyQ9Qfnm1xY+XJWlCGwWY694009 rogid:p7KzZyyr+yMS7ZiMTBx4VVZRzGc694009 rigid:ocDGj5PLjZzRq/lEGJi27smtVIE false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)