#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q75VW8	uniprotkb:Q75VW6	intact:EBI-25397823	intact:EBI-25397811	psi-mi:q75vw8_hydth(display_long)|uniprotkb:ccsA(gene name)|psi-mi:ccsA(display_short)	psi-mi:q75vw6_hydth(display_long)|uniprotkb:ccsB(gene name)|psi-mi:ccsB(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Verschueren et al. (2019)	imex:IM-27931|pubmed:30944476	taxid:940(Hydrogenobacter thermophilus)|taxid:940(Hydrogenobacter thermophilus)	taxid:940(Hydrogenobacter thermophilus)|taxid:940(Hydrogenobacter thermophilus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-25397809|wwpdb:6HXQ|imex:IM-27931-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6HXQ|interpro:IPR013650(ATP-grasp fold, succinyl-CoA synthetase-type)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR032263|interpro:IPR005809(Succinyl-CoA synthetase, beta subunit)|interpro:IPR016102(Succinyl-CoA synthetase-like)|go:"GO:0003878"(ATP citrate synthase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0016874"(ligase activity)	rcsb pdb:6HXQ|interpro:IPR003781(CoA-binding)|interpro:IPR005810(Succinyl-CoA ligase, alpha subunit)|interpro:IPR005811(ATP-citrate lyase/succinyl-CoA ligase)|interpro:IPR036291|interpro:IPR016102(Succinyl-CoA synthetase-like)|go:"GO:0003824"(catalytic activity)	-	-	-	figure legend:Extended Data Fig 1, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2020/01/10	2020/01/15	rogid:iSYojzgJ4a7MGJvdiiehOGd1cEE940	rogid:GVP4IGuqYsqoAG6z1dugdLOd83M940	rigid:GLmYOmN6vICrkoQr959J8Kl01h4	false	-	-	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9AJC4	uniprotkb:Q9AQH6	intact:EBI-25397843	intact:EBI-25397892	psi-mi:q9ajc4_chlli(display_long)|uniprotkb:aclA(gene name)|psi-mi:aclA(display_short)	psi-mi:q9aqh6_chlli(display_long)|uniprotkb:aclB(gene name)|psi-mi:aclB(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Verschueren et al. (2019)	imex:IM-27931|pubmed:30944476	taxid:1092(Chlorobium limicola)|taxid:1092(Chlorobium limicola)	taxid:1092(Chlorobium limicola)|taxid:1092(Chlorobium limicola)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-25397888|wwpdb:6HXJ|imex:IM-27931-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6HXJ|rcsb pdb:6HXN|rcsb pdb:6HXO|rcsb pdb:6QCL|interpro:IPR016142(Citrate synthase-like, large alpha subdomain)|interpro:IPR016143(Citrate synthase-like, small alpha subdomain)|interpro:IPR002020(Citrate synthase-like)|interpro:IPR036969|interpro:IPR003781(CoA-binding)|interpro:IPR005811(ATP-citrate lyase/succinyl-CoA ligase)|interpro:IPR036291|interpro:IPR016102(Succinyl-CoA synthetase-like)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0016829"(lyase activity)|go:"GO:0046912"(acyltransferase, acyl groups converted into alkyl on transfer)|go:"GO:0006629"(lipid metabolic process)|rcsb pdb:6NZY	go:"GO:0003878"(ATP citrate synthase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0016829"(lyase activity)|go:"GO:0016874"(ligase activity)|go:"GO:0046872"(metal ion binding)|rcsb pdb:6HXJ|interpro:IPR011761(ATP-grasp fold)|interpro:IPR013650(ATP-grasp fold, succinyl-CoA synthetase-type)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR032263|interpro:IPR017866|interpro:IPR005809(Succinyl-CoA synthetase, beta subunit)|interpro:IPR016102(Succinyl-CoA synthetase-like)	-	-	-	figure legend:Extended Data Fig 1, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2020/01/10	2020/01/15	rogid:kOFNnHu2b/BJnwPHoXCkRbvD3+k1092	rogid:stbJUziyM2Nzn1PnGyro/4YTi0s1092	rigid:MSmNsNV33P4glHNzXHbMtE7VGHc	false	-	-	4	4	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:A0A1V4VDZ9	uniprotkb:A0A0W8FB26	intact:EBI-25397927|ensemblbacteria:OPX83282	intact:EBI-25397914	psi-mi:a0a1v4vdz9_9eury(display_long)|uniprotkb:sucD(gene name)|psi-mi:sucD(display_short)|uniprotkb:A4E43_00138(orf name)	psi-mi:a0a0w8fb26_9zzzz(display_long)|uniprotkb:ASZ90_012237(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	Verschueren et al. (2019)	imex:IM-27931|pubmed:30944476	taxid:1811683(Methanosaeta sp. PtaB.Bin005)|taxid:1811683(Methanosaeta sp. PtaB.Bin005)	taxid:938273(hydrocarbon metagenome)|taxid:938273(hydrocarbon metagenome)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-25397911|wwpdb:6HXI|imex:IM-27931-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:A4E43_00138(gene)|ensemblbacteria:OPX83282(transcript)|go:"GO:0004775"("succinate-CoA ligase (ADP-forming) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0043758"("acetate-CoA ligase (ADP-forming) activity")|go:"GO:0046912"(acyltransferase, acyl groups converted into alkyl on transfer)|rcsb pdb:6HXI|interpro:IPR016142(Citrate synthase-like, large alpha subdomain)|interpro:IPR016143(Citrate synthase-like, small alpha subdomain)|interpro:IPR002020(Citrate synthase-like)|interpro:IPR036969|interpro:IPR003781(CoA-binding)|interpro:IPR005811(ATP-citrate lyase/succinyl-CoA ligase)|interpro:IPR036291|interpro:IPR016102(Succinyl-CoA synthetase-like)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003878"(ATP citrate synthase activity)|go:"GO:0016829"(lyase activity)|rcsb pdb:6HXI|interpro:IPR013650(ATP-grasp fold, succinyl-CoA synthetase-type)|interpro:IPR032263|interpro:IPR016102(Succinyl-CoA synthetase-like)	-	-	-	figure legend:Extended Data Fig 1, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2020/01/10	2020/04/27	rogid:HdpQEOu8uNSYfJAQfqIcWzrytIo1811683	rogid:ojb5hhvj176krDyyQ/XlkU4D9Qs938273	rigid:A0Ut7JdKOFE7VAUwtdj2TUj6JmU	false	-	-	4	4	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53396-2	uniprotkb:P53396-2	intact:EBI-16399011|ensembl:ENSP00000345398|ensembl:ENSP00000377474	intact:EBI-16399011|ensembl:ENSP00000345398|ensembl:ENSP00000377474	psi-mi:p53396-2(display_long)|uniprotkb:"ATP-citrate (pro-S-)-lyase"(gene name synonym)|uniprotkb:Citrate cleavage enzyme(gene name synonym)|uniprotkb:ACLY(gene name)|psi-mi:ACLY(display_short)	psi-mi:p53396-2(display_long)|uniprotkb:"ATP-citrate (pro-S-)-lyase"(gene name synonym)|uniprotkb:Citrate cleavage enzyme(gene name synonym)|uniprotkb:ACLY(gene name)|psi-mi:ACLY(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Verschueren et al. (2019)	imex:IM-27931|pubmed:30944476	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-25397964|wwpdb:6HXH|wwpdb:6QFB|wwpdb:6HXK|wwpdb:6HXL|wwpdb:6HXM|imex:IM-27931-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000131473(gene)|ensembl:ENST00000353196(transcript)|ensembl:ENST00000393896(transcript)|intact:EBI-1042794(isoform-parent)	ensembl:ENSG00000131473(gene)|ensembl:ENST00000353196(transcript)|ensembl:ENST00000393896(transcript)|intact:EBI-1042794(isoform-parent)	-	-	-	figure legend:Extended Data Fig 1, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2020/01/10	2020/01/15	rogid:pBJJcwGUAn6Tyx0dgKPXQtcoLFE9606	rogid:pBJJcwGUAn6Tyx0dgKPXQtcoLFE9606	rigid:k3AEnBKoJiFC0h/P7xtn5udioL0	false	-	-	4	0	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:Q9AJC4	uniprotkb:Q9AJC4	intact:EBI-25397843	intact:EBI-25397843	psi-mi:q9ajc4_chlli(display_long)|uniprotkb:aclA(gene name)|psi-mi:aclA(display_short)	psi-mi:q9ajc4_chlli(display_long)|uniprotkb:aclA(gene name)|psi-mi:aclA(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Verschueren et al. (2019)	imex:IM-27931|pubmed:30944476	taxid:1092(Chlorobium limicola)|taxid:1092(Chlorobium limicola)	taxid:1092(Chlorobium limicola)|taxid:1092(Chlorobium limicola)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-25397972|wwpdb:6HXN|wwpdb:6HXO|wwpdb:6QCL|imex:IM-27931-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6HXJ|rcsb pdb:6HXN|rcsb pdb:6HXO|rcsb pdb:6QCL|interpro:IPR016142(Citrate synthase-like, large alpha subdomain)|interpro:IPR016143(Citrate synthase-like, small alpha subdomain)|interpro:IPR002020(Citrate synthase-like)|interpro:IPR036969|interpro:IPR003781(CoA-binding)|interpro:IPR005811(ATP-citrate lyase/succinyl-CoA ligase)|interpro:IPR036291|interpro:IPR016102(Succinyl-CoA synthetase-like)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0016829"(lyase activity)|go:"GO:0046912"(acyltransferase, acyl groups converted into alkyl on transfer)|go:"GO:0006629"(lipid metabolic process)|rcsb pdb:6NZY	rcsb pdb:6HXJ|rcsb pdb:6HXN|rcsb pdb:6HXO|rcsb pdb:6QCL|interpro:IPR016142(Citrate synthase-like, large alpha subdomain)|interpro:IPR016143(Citrate synthase-like, small alpha subdomain)|interpro:IPR002020(Citrate synthase-like)|interpro:IPR036969|interpro:IPR003781(CoA-binding)|interpro:IPR005811(ATP-citrate lyase/succinyl-CoA ligase)|interpro:IPR036291|interpro:IPR016102(Succinyl-CoA synthetase-like)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0016829"(lyase activity)|go:"GO:0046912"(acyltransferase, acyl groups converted into alkyl on transfer)|go:"GO:0006629"(lipid metabolic process)|rcsb pdb:6NZY	-	-	-	figure legend:Extended Data Fig 1, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2020/01/10	2020/01/15	rogid:kOFNnHu2b/BJnwPHoXCkRbvD3+k1092	rogid:kOFNnHu2b/BJnwPHoXCkRbvD3+k1092	rigid:lANobpM2NfXwshbi8Xz1TKduuKE	false	-	-	4	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q75VX1	uniprotkb:Q75VX1	intact:EBI-25397796	intact:EBI-25397796	psi-mi:q75vx1_hydth(display_long)|uniprotkb:ccl(gene name)|psi-mi:ccl(display_short)	psi-mi:q75vx1_hydth(display_long)|uniprotkb:ccl(gene name)|psi-mi:ccl(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Verschueren et al. (2019)	imex:IM-27931|pubmed:30944476	taxid:940(Hydrogenobacter thermophilus)|taxid:940(Hydrogenobacter thermophilus)	taxid:940(Hydrogenobacter thermophilus)|taxid:940(Hydrogenobacter thermophilus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-25397978|wwpdb:6HXP|imex:IM-27931-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0016829"(lyase activity)|go:"GO:0046912"(acyltransferase, acyl groups converted into alkyl on transfer)|rcsb pdb:6HXP|interpro:IPR016142(Citrate synthase-like, large alpha subdomain)|interpro:IPR016143(Citrate synthase-like, small alpha subdomain)|interpro:IPR002020(Citrate synthase-like)|interpro:IPR036969	go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0016829"(lyase activity)|go:"GO:0046912"(acyltransferase, acyl groups converted into alkyl on transfer)|rcsb pdb:6HXP|interpro:IPR016142(Citrate synthase-like, large alpha subdomain)|interpro:IPR016143(Citrate synthase-like, small alpha subdomain)|interpro:IPR002020(Citrate synthase-like)|interpro:IPR036969	-	-	-	figure legend:Extended Data Fig 1, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2020/01/10	2020/01/15	rogid:OurHRHooemsS87pIk2Li+yPqitY940	rogid:OurHRHooemsS87pIk2Li+yPqitY940	rigid:TYK0+Y4NkdGDOAOJ7ueKFp8f0PU	false	-	-	4	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)