#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P50897 uniprotkb:Q545A2 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-7596427|intact:MINT-8297439 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:q545a2_mouse(display_long)|uniprotkb:Slc25a5(gene name)|psi-mi:Slc25a5(display_short)|uniprotkb:ADP,ATP carrier protein(gene name synonym) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) interpro:IPR023395|refseq:NP_031477.1|interpro:IPR018108|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR002067(Mitochondrial carrier protein)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045121"(membrane raft)|go:"GO:0071817"(MMXD complex)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1901029"(negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005743"(mitochondrial inner membrane)|mint:Q545A2 - - comment:mint figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:146+I0bORlUf6z9chvmdXwUCtOs10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:Q9QUR8 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-8330031|intact:MINT-4134084|uniprotkb:O88371|ensembl:ENSMUSP00000042211 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:sem7a_mouse(display_long)|uniprotkb:Sema7a(gene name)|psi-mi:Sema7a(display_short)|uniprotkb:Cd108(gene name synonym)|uniprotkb:Semal(gene name synonym)|uniprotkb:Semk1(gene name synonym)|uniprotkb:Semaphorin-K1(gene name synonym)|uniprotkb:Semaphorin-L(gene name synonym) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) refseq:NP_035482.1|go:"GO:0007411"(axon guidance)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0021988"(olfactory lobe development)|go:"GO:0030215"(semaphorin receptor binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031175"(neuron projection development)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048675"(axon extension)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027231|interpro:IPR036179|interpro:IPR036352|interpro:IPR042824|mint:Q9QUR8|reactome:R-MMU-416700|go:"GO:0007229"(integrin-mediated signaling pathway)|ensembl:ENSMUSG00000038264(gene)|ensembl:ENSMUST00000043059(transcript)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response) - - comment:mint|function:May play an imortant role in the nervous system and in modulating immune function figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:IaJn4BX9px5pC8+y1GxtEMhaNro10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:Q99PI8 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-7766036|ensembl:ENSMUSP00000062924|uniprotkb:Q80WQ1|intact:MINT-188355 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:rtn4r_mouse(display_long)|uniprotkb:Ngr1(gene name synonym)|uniprotkb:Nogo66 receptor-1(gene name synonym)|uniprotkb:Rtn4r(gene name)|psi-mi:Rtn4r(display_short)|uniprotkb:Nogor(gene name synonym)|uniprotkb:Nogo receptor(gene name synonym)|uniprotkb:Nogo-66 receptor(gene name synonym) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) ensembl:ENSMUSG00000043811(gene)|ensembl:ENSMUST00000059589(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0022038"(corpus callosum development)|go:"GO:0023041"(neuronal signal transduction)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031362"(anchored component of external side of plasma membrane)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038131"(neuregulin receptor activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048495"(Roundabout binding)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905576"(ganglioside GT1b binding)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|mint:Q99PI8|rcsb pdb:5O0K|rcsb pdb:5O0L|rcsb pdb:5O0M|rcsb pdb:5O0N|rcsb pdb:5O0O|rcsb pdb:5O0Q|rcsb pdb:5O0R|rcsb pdb:5O0P|refseq:NP_075358.1 - - comment:mint|function:Receptor for RTN4, OMG and MAG. Mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:TQ/XncSvF4z/pYDIDf7gNZk8b8010090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:Q3U1F9 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427 - - function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:P63101 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-354751|uniprotkb:P35215|uniprotkb:P70197|uniprotkb:P97286|uniprotkb:Q3TSF1|uniprotkb:Q5EBQ1|ensembl:ENSMUSP00000022894|ensembl:ENSMUSP00000105990|ensembl:ENSMUSP00000105991 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:1433z_mouse(display_long)|uniprotkb:Ywhaz(gene name)|psi-mi:Ywhaz(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:SEZ-2(gene name synonym) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) refseq:NP_001240734.1|refseq:NP_001240735.1|refseq:NP_035870.1|refseq:XP_011243654.1|ensembl:ENSMUSG00000022285(gene)|ensembl:ENSMUST00000110361(transcript)|ensembl:ENSMUST00000110362(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0003016"(respiratory system process)|ensembl:ENSMUST00000022894(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006605"(protein targeting)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0007165"(signal transduction)|go:"GO:0008039"(synaptic target recognition)|go:"GO:0010941"(regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030324"(lung development)|go:"GO:0031252"(cell leading edge)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035148"(tube formation)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P63101|reactome:R-MMU-111447|reactome:R-MMU-3769402|reactome:R-MMU-392517|reactome:R-MMU-430116|reactome:R-MMU-450604|reactome:R-MMU-512988|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-9013700|reactome:R-MMU-9614399|dip:DIP-31894N - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:v2N95HO8sYRWEg2gFtWiYajP1Sc10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:A8IP69 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-26446791 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:a8ip69_mouse(display_long)|uniprotkb:Ywhag(gene name)|psi-mi:Ywhag(display_short)|uniprotkb:14-3-3 gamma(gene name synonym) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) go:"GO:0098793"(presynapse)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048167"(regulation of synaptic plasticity)|mint:A8IP69|refseq:NP_061359.2|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR036815|interpro:IPR023410 - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:u1cd71h0RPgTOEMrQVhOelsxWnM10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:Q01853 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-80597|ensembl:ENSMUSP00000030164|uniprotkb:Q3TFH9|uniprotkb:Q3TIM2|uniprotkb:Q3TXN9|uniprotkb:Q6PI18|uniprotkb:Q8BSR6|uniprotkb:Q8CEG4 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:tera_mouse(display_long)|uniprotkb:Vcp(gene name)|psi-mi:Vcp(display_short)|uniprotkb:"15S Mg(2+)-ATPase p97 subunit"(gene name synonym)|uniprotkb:Valosin-containing protein(gene name synonym) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072389"(flavin adenine dinucleotide catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043531"(ADP binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0106300"(protein-DNA covalent cross-linking repair)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903006"(positive regulation of protein K63-linked deubiquitination)|go:"GO:1903007"(positive regulation of Lys63-specific deubiquitinase activity)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903843"(cellular response to arsenite ion)|go:"GO:1903862"(positive regulation of oxidative phosphorylation)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904949"(ATPase complex)|go:"GO:1905634"(regulation of protein localization to chromatin)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990730"(VCP-NSFL1C complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|mint:Q01853|rcsb pdb:1E32|rcsb pdb:1R7R|rcsb pdb:1S3S|rcsb pdb:2PJH|rcsb pdb:3CF0|rcsb pdb:3CF1|rcsb pdb:3CF2|rcsb pdb:3CF3|reactome:R-MMU-110320|reactome:R-MMU-3371511|reactome:R-MMU-382556|reactome:R-MMU-532668|reactome:R-MMU-5358346|reactome:R-MMU-5689877|reactome:R-MMU-5689896|reactome:R-MMU-6798695|reactome:R-MMU-8876725|reactome:R-MMU-9013407|ensembl:ENSMUSG00000028452(gene)|ensembl:ENSMUST00000030164(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006914"(autophagy)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008289"(lipid binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019079"(viral genome replication)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032510"(endosome to lysosome transport via multivesicular body sorting pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035617"(stress granule disassembly)|go:"GO:0035800"(deubiquitinase activator activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0036503"(ERAD pathway)|go:"GO:0019904"(protein domain specific binding)|refseq:NP_033529.3|dip:DIP-29796N - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:HrjDhdsDcgaf8HEbqqMjUqxPaEs10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:P68369 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-400542|uniprotkb:P02551|uniprotkb:P05210|uniprotkb:P05212|uniprotkb:Q3TGF0|uniprotkb:Q3TIW2|uniprotkb:Q3TPJ1|uniprotkb:Q3ULN1|uniprotkb:Q5XJF8|ensembl:ENSMUSP00000094778 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:tba1a_mouse(display_long)|uniprotkb:Tuba1a(gene name)|psi-mi:Tuba1a(display_short)|uniprotkb:Tubulin alpha-1 chain(gene name synonym)|uniprotkb:Alpha-tubulin 1(gene name synonym)|uniprotkb:Alpha-tubulin isotype M-alpha-1(gene name synonym)|uniprotkb:Tuba1(gene name synonym) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) refseq:NP_035783.1|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-3371497|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-437239|reactome:R-MMU-5610787|reactome:R-MMU-5617833|reactome:R-MMU-5620912|reactome:R-MMU-5620924|reactome:R-MMU-5626467|reactome:R-MMU-5663220|reactome:R-MMU-6807878|reactome:R-MMU-6811434|reactome:R-MMU-6811436|reactome:R-MMU-68877|reactome:R-MMU-8852276|reactome:R-MMU-8854518|reactome:R-MMU-8955332|reactome:R-MMU-9646399|reactome:R-MMU-9648025|reactome:R-MMU-9668328|reactome:R-MMU-983189|ensembl:ENSMUSG00000072235(gene)|ensembl:ENSMUST00000097014(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0055037"(recycling endosome)|interpro:IPR000217(Tubulin)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P68369|rcsb pdb:6JZD|reactome:R-MMU-190840|reactome:R-MMU-2132295 - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:1CzEzrf5y8hrQRPKgWQS1Wm1aCY10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:B2RRP1 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-26446781 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:b2rrp1_mouse(display_long)|uniprotkb:Tpgs1(gene name)|psi-mi:Tpgs1(display_short)|uniprotkb:Gm16517(gene name synonym)|uniprotkb:Gtrgeo22(gene name synonym) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) go:"GO:0005813"(centrosome)|go:"GO:0018095"(protein polyglutamylation)|mint:B2RRP1|refseq:NP_683736.1|interpro:IPR039235 - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:CNNi+XO6HFs87Nv1puXz45++/OA10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:D3Z108 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-26446770|ensembl:ENSMUSP00000123173 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:d3z108_mouse(display_long)|uniprotkb:Tmub1(gene name)|psi-mi:Tmub1(display_short) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) ensembl:ENSMUSG00000028958(gene)|ensembl:ENSMUST00000127194(transcript)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR040352|mint:D3Z108 - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:BGbky6EZhg0V8L6KFxD1Yjs3G1U10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:Q9CX93 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-26446766 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:q9cx93_mouse(display_long)|uniprotkb:Tmtc2(gene name)|psi-mi:Tmtc2(display_short) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) mint:Q9CX93 - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:0PdfknBgo92FLAIb8hhnZWuyrgo10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:Q53YX2 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-26446736 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:q53yx2_mouse(display_long)|uniprotkb:Thy1(gene name)|psi-mi:Thy1(display_short)|uniprotkb:Thy-1 membrane glycoprotein(gene name synonym) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) go:"GO:0001525"(angiogenesis)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0034235"(GPI anchor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0098609"(cell-cell adhesion)|mint:Q53YX2|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR033292 - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:9Cq4qrd+QLuhNZRYnEyBKbAd3lA10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:O08599 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-445322|uniprotkb:A2ARS2|uniprotkb:A2ARS3|uniprotkb:A2ARS4|uniprotkb:Q5WAC6|uniprotkb:Q8VD51|ensembl:ENSMUSP00000052440 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:stxb1_mouse(display_long)|uniprotkb:Protein unc-18 homolog 1(gene name synonym)|uniprotkb:Protein unc-18 homolog A(gene name synonym)|uniprotkb:Stxbp1(gene name)|psi-mi:Stxbp1(display_short) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) refseq:NP_001107041.1|refseq:NP_033321.2|interpro:IPR043127|interpro:IPR043154|mint:O08599|go:"GO:0098794"(postsynapse)|go:"GO:0098891"(extrinsic component of presynaptic active zone membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099525"(presynaptic dense core vesicle exocytosis)|reactome:R-MMU-181429|reactome:R-MMU-181430|go:"GO:0106022"(positive regulation of vesicle docking)|go:"GO:1903296"(positive regulation of glutamate secretion, neurotransmission)|go:"GO:2000367"(regulation of acrosomal vesicle exocytosis)|interpro:IPR001619(Sec1-like protein)|interpro:IPR027482|interpro:IPR036045|reactome:R-MMU-210500|reactome:R-MMU-212676|reactome:R-MMU-264642|reactome:R-MMU-888590|ensembl:ENSMUSG00000026797(gene)|ensembl:ENSMUST00000050000(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0002576"(platelet degranulation)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007412"(axon target recognition)|go:"GO:0010807"(regulation of synaptic vesicle priming)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030424"(axon)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031338"(regulation of vesicle fusion)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050821"(protein stabilization)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098793"(presynapse)|dip:DIP-31951N - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:yUYi89hDkfMdQ1BdH52swZQFCLk10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:Q62261 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-397843|ensembl:ENSMUSP00000006629|ensembl:ENSMUSP00000011877|uniprotkb:A2AFU1|uniprotkb:Q3TEM7|uniprotkb:Q5SQL8|uniprotkb:Q5SQL9|uniprotkb:Q9QWJ7 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:sptb2_mouse(display_long)|uniprotkb:Sptbn1(gene name)|psi-mi:Sptbn1(display_short)|uniprotkb:Spnb-2(gene name synonym)|uniprotkb:Spnb2(gene name synonym)|uniprotkb:Sptb2(gene name synonym)|uniprotkb:Beta-II spectrin(gene name synonym)|uniprotkb:Fodrin beta chain(gene name synonym)|uniprotkb:Embryonic liver fodrin(gene name synonym)|uniprotkb:Elf(gene name synonym) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) ensembl:ENSMUSG00000020315(gene)|ensembl:ENSMUST00000006629(transcript)|ensembl:ENSMUST00000011877(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0008091"(spectrin)|go:"GO:0012505"(endomembrane system)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031430"(M band)|go:"GO:0032437"(cuticular plate)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051693"(actin filament capping)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0071709"(membrane assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|interpro:IPR041681|mint:Q62261|rcsb pdb:1BTN|rcsb pdb:1MPH|rcsb pdb:6M3P|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6807878|reactome:R-MMU-9013420|reactome:R-MMU-9013424|refseq:NP_033286.2|refseq:NP_787030.2|refseq:XP_006514662.1|refseq:XP_006514663.1|dip:DIP-31558N - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:N6xVFU+ocY6PXsIz5ZIsA05bGPs10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:A3KGU7 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-26446710|ensembl:ENSMUSP00000097797 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:a3kgu7_mouse(display_long)|uniprotkb:Sptan1(gene name)|psi-mi:Sptan1(display_short)|uniprotkb:Spna2(gene name synonym) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) ensembl:ENSMUSG00000057738(gene)|ensembl:ENSMUST00000100225(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005938"(cell cortex)|go:"GO:0051693"(actin filament capping)|interpro:IPR001452(Src homology-3)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR035825|interpro:IPR036028|mint:A3KGU7|refseq:NP_001171138.1 - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:zlZf3LLoutbKEACkmhZYCgoq19w10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:Q8VIJ6 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-6094576|uniprotkb:A2A7U6|uniprotkb:Q9ERW2|ensembl:ENSMUSP00000030623 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:sfpq_mouse(display_long)|uniprotkb:Sfpq(gene name)|psi-mi:Sfpq(display_short)|uniprotkb:DNA-binding p52/p100 complex, 100 kDa subunit(gene name synonym)|uniprotkb:Polypyrimidine tract-binding protein-associated-splicing factor(gene name synonym)|uniprotkb:Psf(gene name synonym) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) refseq:NP_076092.1|ensembl:ENSMUSG00000028820(gene)|ensembl:ENSMUST00000030623(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0042382"(paraspeckles)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045876"(positive regulation of sister chromatid cohesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048511"(rhythmic process)|go:"GO:0051276"(chromosome organization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012975(NOPS)|interpro:IPR034525|interpro:IPR034526|interpro:IPR035979|mint:Q8VIJ6|reactome:R-MMU-8849468 - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:9mciNgfKrEvyAv7kjs55FHlUtRY10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:Q5YLW3 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-26446646 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:q5ylw3_mouse(display_long)|uniprotkb:Rps3(gene name)|psi-mi:Rps3(display_short) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) go:"GO:0140078"("class I DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:0051301"(cell division)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005819"(spindle)|go:"GO:0006281"(DNA repair)|go:"GO:0006412"(translation)|go:"GO:0006417"(regulation of translation)|go:"GO:0006915"(apoptotic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0019900"(kinase binding)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030425"(dendrite)|go:"GO:0042981"(regulation of apoptotic process)|mint:Q5YLW3|refseq:NP_036182.1|interpro:IPR015946(K homology-like, alpha/beta)|interpro:IPR004044(K Homology, type 2)|interpro:IPR009019(K Homology, prokaryotic type)|interpro:IPR001351(Ribosomal protein S3, C-terminal)|interpro:IPR036419|interpro:IPR018280|interpro:IPR005703(Ribosomal protein S3, eukaryotic/archaeal) - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:f4Vh6HESE+lKZinjkJ883IG3wiY10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:Q3U561 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-26446633 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:q3u561_mouse(display_long)|uniprotkb:Rpl10a(gene name)|psi-mi:Rpl10a(display_short) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0006412"(translation)|go:"GO:0015934"(large ribosomal subunit)|mint:Q3U561|interpro:IPR002143(Ribosomal protein L1)|interpro:IPR023674|interpro:IPR028364|interpro:IPR016095(Ribosomal protein L1, 3-layer alpha/beta-sandwich)|interpro:IPR023673 - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:8EAIPQ+YAlTcGolFPvwGlhCnfQs10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 intact:EBI-26446606 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 - psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:f8vqd7_mouse(display_short)|psi-mi:EBI-26446606(display_long)|uniprotkb:Ptprg(gene name)|psi-mi:Ptprg(display_short) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) uniprotkb:F8VQD7(uniprot-removed-ac) - - no-uniprot-update:|caution:The sequence has been withdrawn from uniprot. figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:Gl34yJ/3+dyBexo/82StrcvEpwE10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:Q3TVY0 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-26446597 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:q3tvy0_mouse(display_long)|uniprotkb:Psmd8(gene name)|psi-mi:Psmd8(display_short) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0006508"(proteolysis)|mint:Q3TVY0|interpro:IPR006746(26S proteasome non-ATPase regulatory subunit Rpn12)|interpro:IPR033464|interpro:IPR000717(Proteasome component region PCI) - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:VDkKeYRRkAG7bbPVS2FSf+BuJ0I10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:Q3THL2 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-4283753 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:q3thl2_mouse(display_long)|uniprotkb:Psma7(gene name)|psi-mi:Psma7(display_short) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) interpro:IPR023332|interpro:IPR001353(20S proteasome, A and B subunits)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|refseq:NP_001276405.1|interpro:IPR029055|interpro:IPR035190|mint:Q3THL2 - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:40phN4FYZWAmjdKRst1nqlt9N+U10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:Q3TS44 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-4283636 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:q3ts44_mouse(display_long)|uniprotkb:Psma1(gene name)|psi-mi:Psma1(display_short) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) refseq:NP_036095.1|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR023332|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR029055|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|interpro:IPR035144|mint:Q3TS44 - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:5AV1kxiJdOzf5jh1YRmUL94hQwk10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:Q3TEL0 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-26446586 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:q3tel0_mouse(display_long)|uniprotkb:Ppt1(gene name)|psi-mi:Ppt1(display_short)|uniprotkb:Palmitoyl-protein thioesterase 1(gene name synonym) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) go:"GO:0002084"(protein depalmitoylation)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|mint:Q3TEL0|refseq:NP_032943.2|interpro:IPR029058|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR030294 - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:c2I31TtYBlW68TZ0X52BjWMPfes10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:Q3U8W0 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-26446572 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:q3u8w0_mouse(display_long)|uniprotkb:Ppp1ca(gene name)|psi-mi:Ppp1ca(display_short) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0051301"(cell division)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0106306"|go:"GO:0106307"|mint:Q3U8W0|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR029052|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR031675|interpro:IPR037979 - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:D4PnbzcJFGMrlCHdyMp6exhAxpw10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:P67778 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-298507|uniprotkb:P24142|uniprotkb:Q3UB75|uniprotkb:Q5SQG4|ensembl:ENSMUSP00000119603 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:phb_mouse(display_long)|uniprotkb:Phb(gene name)|psi-mi:Phb(display_short)|uniprotkb:B-cell receptor-associated protein 32(gene name synonym) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) ensembl:ENSMUSG00000038845(gene)|ensembl:ENSMUST00000125172(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001552"(ovarian follicle atresia)|go:"GO:0001850"(complement component C3a binding)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031315"(extrinsic component of mitochondrial outer membrane)|go:"GO:0031871"(proteinase activated receptor binding)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0035632"(mitochondrial prohibitin complex)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0042113"(B cell activation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045471"(response to ethanol)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045917"(positive regulation of complement activation)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0098891"(extrinsic component of presynaptic active zone membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1990051"(activation of protein kinase C activity)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000163(Prohibitin)|interpro:IPR001107(Band 7 protein)|interpro:IPR036013|mint:P67778|reactome:R-MMU-5673000|reactome:R-MMU-8949664|refseq:NP_032857.1 - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:eUStcZ9Mu7+7MHr/GJXFwwJY/Fc10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:Q3U7Z6 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-26446553 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:q3u7z6_mouse(display_long)|uniprotkb:Pgam1(gene name)|psi-mi:Pgam1(display_short) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) go:"GO:0004082"(bisphosphoglycerate mutase activity)|go:"GO:0004619"(phosphoglycerate mutase activity)|go:"GO:0005634"(nucleus)|go:"GO:0006096"(glycolytic process)|go:"GO:0016787"(hydrolase activity)|mint:Q3U7Z6|refseq:NP_075907.2|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR029033|interpro:IPR001345(Phosphoglycerate/bisphosphoglycerate mutase)|interpro:IPR005952(Phosphoglycerate mutase 1) - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:yXIwDvILEZUyPCtOTpZy0JxclWg10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:Q3TYL3 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-26446543 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:q3tyl3_mouse(display_long)|uniprotkb:Opcml(gene name)|psi-mi:Opcml(display_short) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) mint:Q3TYL3|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2) - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:7lgMpuR1hQhH+tDcMjbOWh5M5tg10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:Q8R357 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-26446521|ensembl:ENSMUSP00000028177 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:q8r357_mouse(display_long)|uniprotkb:Olfm1(gene name)|psi-mi:Olfm1(display_short) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) ensembl:ENSMUSG00000026833(gene)|ensembl:ENSMUST00000028177(transcript)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0005576"(extracellular region)|go:"GO:0007399"(nervous system development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|interpro:IPR003112(Olfactomedin-like)|interpro:IPR011044(Quinoprotein amine dehydrogenase, beta chain-like)|interpro:IPR022082|interpro:IPR031217|mint:Q8R357|refseq:NP_001033702.1|refseq:NP_062371.2 - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:Ru3vIm1LGlRZyAaiU3cfYrBIdlI10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:F7D418 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-26446510|ensembl:ENSMUSP00000125147 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:f7d418_mouse(display_long)|uniprotkb:Nbeal1(gene name)|psi-mi:Nbeal1(display_short) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) ensembl:ENSMUSG00000073664(gene)|ensembl:ENSMUST00000160980(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0008104"(protein localization)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|mint:F7D418 - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:Z0k/xf1SCS/+pw/vwORqXoBmX4010090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:Q61879 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-400918|uniprotkb:Q5SV63|ensembl:ENSMUSP00000099671 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:myh10_mouse(display_long)|uniprotkb:Myh10(gene name)|psi-mi:Myh10(display_short)|uniprotkb:Myosin heavy chain 10(gene name synonym)|uniprotkb:Myosin heavy chain, non-muscle IIb(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain IIb(gene name synonym)|uniprotkb:Cellular myosin heavy chain, type B(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain B(gene name synonym) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) refseq:NP_780469.1|ensembl:ENSMUSG00000020900(gene)|ensembl:ENSMUST00000102611(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001725"(stress fiber)|go:"GO:0001764"(neuron migration)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0003279"(cardiac septum development)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005903"(brush border)|go:"GO:0005938"(cell cortex)|go:"GO:0006887"(exocytosis)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007097"(nuclear migration)|go:"GO:0007155"(cell adhesion)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0007512"(adult heart development)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016459"(myosin complex)|go:"GO:0016460"(myosin II complex)|go:"GO:0021592"(fourth ventricle development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0021678"(third ventricle development)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030239"(myofibril assembly)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032154"(cleavage furrow)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0035904"(aorta development)|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043531"(ADP binding)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0070650"(actin filament bundle distribution)|go:"GO:0097513"(myosin II filament)|dip:DIP-31956N|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR036961|mint:Q61879|reactome:R-MMU-5627123 - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:DE0ILvXp+FsQ8J8yXJ38FaeQtzM10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:Q0H9Q2 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-26446504 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:q0h9q2_mouse(display_long)|uniprotkb:Maz(gene name)|psi-mi:Maz(display_short) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) mint:Q0H9Q2|interpro:IPR036236|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding) - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:E6yy+Ca/DOqtuU75s2flC41p+6U10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:Q3U4H0 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-26446479 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:q3u4h0_mouse(display_long)|uniprotkb:Mapre1(gene name)|psi-mi:Mapre1(display_short)|uniprotkb:End-binding protein 1(gene name synonym)|uniprotkb:Microtubule-associated protein RP/EB family member 1(gene name synonym) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) go:"GO:0005813"(centrosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0007049"(cell cycle)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030981"(cortical microtubule cytoskeleton)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0042802"(identical protein binding)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051301"(cell division)|go:"GO:1905721"(mitotic spindle astral microtubule end)|mint:Q3U4H0|refseq:NP_031922.1|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR036872|interpro:IPR004953(EB1, C-terminal)|interpro:IPR036133|interpro:IPR027739|interpro:IPR027328 - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:HQQfAZTgxRU4kb8LGRRwKkDpLx810090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:A0A087WP80 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-26446465|ensembl:ENSMUSP00000139667 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:a0a087wp80_mouse(display_long)|uniprotkb:Lsamp(gene name)|psi-mi:Lsamp(display_short) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) ensembl:ENSMUSG00000061080(gene)|ensembl:ENSMUST00000187695(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:A0A087WP80 - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:kEuF8Wsz/JcM9cX3QCtAD5Haq4c10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:P16125 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-444932|uniprotkb:Q545Y4|ensembl:ENSMUSP00000032373|ensembl:ENSMUSP00000159362 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:ldhb_mouse(display_long)|uniprotkb:LDH heart subunit(gene name synonym)|uniprotkb:Ldhb(gene name)|psi-mi:Ldhb(display_short)|uniprotkb:Ldh-2(gene name synonym)|uniprotkb:Ldh2(gene name synonym) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) refseq:NP_032518.1|refseq:NP_001303251.1|ensembl:ENSMUSG00000030246(gene)|ensembl:ENSMUST00000032373(transcript)|ensembl:ENSMUST00000239397(transcript)|go:"GO:0004457"(lactate dehydrogenase activity)|go:"GO:0004459"(L-lactate dehydrogenase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006089"(lactate metabolic process)|go:"GO:0019244"(lactate biosynthetic process from pyruvate)|go:"GO:0019674"(NAD metabolic process)|go:"GO:0019900"(kinase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0051287"(NAD binding)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR011304(L-lactate dehydrogenase)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR018177|interpro:IPR022383|interpro:IPR036291|mint:P16125|reactome:R-MMU-70268|interpro:IPR001557(L-lactate/malate dehydrogenase)|refseq:NP_001289694.1 - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:jN0wT7b/jHBnWCfV48irZYeGxa410090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:Q6NXH9 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-6877367|ensembl:ENSMUSP00000065349 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:k2c73_mouse(display_long)|uniprotkb:Krt73(gene name)|psi-mi:Krt73(display_short)|uniprotkb:Kb36(gene name synonym)|uniprotkb:Cytokeratin-73(gene name synonym)|uniprotkb:Keratin-73(gene name synonym)|uniprotkb:Type II inner root sheath-specific keratin-K6irs3(gene name synonym)|uniprotkb:Type-II keratin Kb36(gene name synonym) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) ensembl:ENSMUSG00000063661(gene)|ensembl:ENSMUST00000063292(transcript)|go:"GO:0045095"(keratin filament)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|mint:Q6NXH9|reactome:R-MMU-6805567|reactome:R-MMU-6809371|refseq:NP_997650.1 - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:y7OkORSkYXKGf7/1Gs0fPdL9NtY10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:Q7TNR6 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-774495|ensembl:ENSMUSP00000046558 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:igs21_mouse(display_long)|uniprotkb:Igsf21(gene name)|psi-mi:Igsf21(display_short) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) refseq:NP_941012.1|ensembl:ENSMUSG00000040972(gene)|ensembl:ENSMUST00000039331(transcript)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0031362"(anchored component of external side of plasma membrane)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060074"(synapse maturation)|go:"GO:0060077"(inhibitory synapse)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q7TNR6 - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:CSBnXH1HlH2exkfyaX4++pwnuD010090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:Q8HW98 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-26446449|ensembl:ENSMUSP00000103608|uniprotkb:A7E1X9 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:iglo5_mouse(display_long)|uniprotkb:Iglon5(gene name)|psi-mi:Iglon5(display_short) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) ensembl:ENSMUSG00000013367(gene)|ensembl:ENSMUST00000107974(transcript)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q8HW98|go:"GO:0005576"(extracellular region)|refseq:NP_001157990.1 - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:Unf9CuuvPwjXv8/4lRz6619YmdU10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:F8WHY9 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-26446436|ensembl:ENSMUSP00000014089 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:f8why9_mouse(display_long)|uniprotkb:Gpc2(gene name)|psi-mi:Gpc2(display_short) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) ensembl:ENSMUSG00000029510(gene)|ensembl:ENSMUST00000014089(transcript)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001863(Glypican)|interpro:IPR019803|interpro:IPR031181|mint:F8WHY9 - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:sqSaXdX69YKriXJpNvPiYPhyZAs10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:Q3U379 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-26446419 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:q3u379_mouse(display_long)|uniprotkb:Gpc1(gene name)|psi-mi:Gpc1(display_short)|uniprotkb:Secreted glypican-1(gene name synonym) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) go:"GO:0005829"(cytosol)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0030200"(heparan sulfate proteoglycan catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005507"(copper ion binding)|go:"GO:0005615"(extracellular space)|mint:Q3U379|refseq:NP_057905.1|interpro:IPR001863(Glypican)|interpro:IPR015502(Glypican1)|interpro:IPR019803 - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:ZgjHg2dYJ7bErmaacYVvVQFB1Mc10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:Q3THF3 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-26446406 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:q3thf3_mouse(display_long)|uniprotkb:Gnb4(gene name)|psi-mi:Gnb4(display_short) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) go:"GO:0007165"(signal transduction)|mint:Q3THF3|interpro:IPR020472|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR019775|interpro:IPR036322 - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:2wqKXE044wWGdndIIaOunA2SBRw10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:Q3U9V4 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-26446385 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:q3u9v4_mouse(display_long)|uniprotkb:Gnb2(gene name)|psi-mi:Gnb2(display_short) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) go:"GO:0007165"(signal transduction)|mint:Q3U9V4|interpro:IPR036322|refseq:NP_034442.1|refseq:XP_006504616.1|interpro:IPR020472|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR019775 - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:dingPUxdpAhe7UMLquv0eqXNtUM10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:Q3TQ70 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-26446356 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:q3tq70_mouse(display_long)|uniprotkb:Gnb1(gene name)|psi-mi:Gnb1(display_short) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030425"(dendrite)|go:"GO:0030507"(spectrin binding)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0044297"(cell body)|go:"GO:0047391"(alkylglycerophosphoethanolamine phosphodiesterase activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071456"(cellular response to hypoxia)|mint:Q3TQ70|refseq:NP_001153488.1|refseq:NP_001153489.1|refseq:NP_032168.1|refseq:XP_017175466.1|interpro:IPR020472|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR019775|interpro:IPR036322 - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:zP/G70MXiSQpzbyyWFTWrJFQENk10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:O08842 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-26446322|ensembl:ENSMUSP00000022699|uniprotkb:Q3UUD8|uniprotkb:Q920Y3|uniprotkb:Q9Z2A2|uniprotkb:Q9Z2A3 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:gfra2_mouse(display_long)|uniprotkb:Gfra2(gene name)|psi-mi:Gfra2(display_short)|uniprotkb:Gdnfrb(gene name synonym)|uniprotkb:Trnr2(gene name synonym)|uniprotkb:GDNF receptor beta(gene name synonym)|uniprotkb:Neurturin receptor alpha(gene name synonym)|uniprotkb:TGF-beta-related neurotrophic factor receptor 2(gene name synonym) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) ensembl:ENSMUSG00000022103(gene)|ensembl:ENSMUST00000022699(transcript)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016167"(glial cell-derived neurotrophic factor receptor activity)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043235"(receptor complex)|interpro:IPR003438(Glial cell line-derived neurotrophic factor receptor)|interpro:IPR003504(Glial cell line-derived neurotrophic factor receptor alpha 2)|interpro:IPR016017(GDNF/GAS1)|interpro:IPR017372(Glial cell line-derived neurotrophic factor receptor, alpha 1/2)|interpro:IPR037193|mint:O08842|reactome:R-MMU-5673001|reactome:R-MMU-8853659|refseq:NP_001289023.1|refseq:NP_001289024.1|refseq:NP_032141.2 - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:WtI/fFyfRmDETO3VdZQSJK598NM10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:A0A097BVN3 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-26446310 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:a0a097bvn3_mouse(display_long)|uniprotkb:Gfra1(gene name)|psi-mi:Gfra1(display_short) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) go:"GO:0005886"(plasma membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0038023"(signaling receptor activity)|mint:A0A097BVN3|interpro:IPR016017(GDNF/GAS1)|interpro:IPR037193|interpro:IPR003438(Glial cell line-derived neurotrophic factor receptor)|interpro:IPR003503(Glial cell line-derived neurotrophic factor receptor, alpha 1)|interpro:IPR017372(Glial cell line-derived neurotrophic factor receptor, alpha 1/2) - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:pLOWjg78+09FSaEYyp02BWU5QAo10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:P50396 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-1634930|uniprotkb:A2AMA8|uniprotkb:Q3TBI9|uniprotkb:Q8VHM3|uniprotkb:Q91Y71|uniprotkb:Q91Z41|uniprotkb:Q96CX5|ensembl:ENSMUSP00000015435 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:gdia_mouse(display_long)|uniprotkb:Gdi1(gene name)|psi-mi:Gdi1(display_short)|uniprotkb:Rabgdia(gene name synonym)|uniprotkb:Guanosine diphosphate dissociation inhibitor 1(gene name synonym) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) ensembl:ENSMUSG00000015291(gene)|ensembl:ENSMUST00000015435(transcript)|go:"GO:0005093"(Rab GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030424"(axon)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|refseq:NP_034403.1|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0051592"(response to calcium ion)|go:"GO:0090315"(negative regulation of protein targeting to membrane)|interpro:IPR000806(Rab GDI protein)|interpro:IPR018203|interpro:IPR036188|mint:P50396|reactome:R-MMU-8876198|go:"GO:0043209"(myelin sheath) - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:PedrlfCE1ZCgXPtL9PZmNfOoxdo10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:A0A0A0MQF6 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-26446291|ensembl:ENSMUSP00000113942 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:a0a0a0mqf6_mouse(display_long)|uniprotkb:Gapdh(gene name)|psi-mi:Gapdh(display_short) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) interpro:IPR020829|interpro:IPR020830|interpro:IPR020831|interpro:IPR036291|mint:A0A0A0MQF6|ensembl:ENSMUSG00000057666(gene)|ensembl:ENSMUST00000117757(transcript)|go:"GO:0004365"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity")|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding)|interpro:IPR006424(Glyceraldehyde-3-phosphate dehydrogenase, type I)|interpro:IPR020828|refseq:NP_001276655.1 - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:1S/f8HfxxhUjuU4SOrB7H5w/VS010090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:P06837 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-400716|ensembl:ENSMUSP00000099881 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:neum_mouse(display_long)|uniprotkb:Gap43(gene name)|psi-mi:Gap43(display_short)|uniprotkb:Basp2(gene name synonym)|uniprotkb:Axonal membrane protein GAP-43(gene name synonym)|uniprotkb:Growth-associated protein 43(gene name synonym)|uniprotkb:Calmodulin-binding protein P-57(gene name synonym) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) refseq:NP_032109.1|ensembl:ENSMUSG00000047261(gene)|ensembl:ENSMUST00000102817(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007411"(axon guidance)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016198"(axon choice point recognition)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031103"(axon regeneration)|go:"GO:0031527"(filopodium membrane)|go:"GO:0032584"(growth cone membrane)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0040008"(regulation of growth)|go:"GO:0042246"(tissue regeneration)|go:"GO:0043204"(perikaryon)|go:"GO:0045165"(cell fate commitment)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0071944"(cell periphery)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099150"(regulation of postsynaptic specialization assembly)|go:"GO:1901981"(phosphatidylinositol phosphate binding)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001422("Neuromodulin (GAP-43)")|interpro:IPR017454("Neuromodulin (GAP-43), C-terminal")|interpro:IPR018243|interpro:IPR018947|interpro:IPR033137|mint:P06837|rcsb pdb:4E53|reactome:R-MMU-373760 - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:z2h3N6h1rCfv/Ty0dMixCedy7k010090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:P39688 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-524514|uniprotkb:Q3TAT3|uniprotkb:Q3U0T5|uniprotkb:Q8K2A3|ensembl:ENSMUSP00000097547 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:fyn_mouse(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Fyn(gene name)|psi-mi:Fyn(display_short)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) ensembl:ENSMUSG00000019843(gene)|ensembl:ENSMUST00000099967(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001764"(neuron migration)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003015"(heart process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042552"(myelination)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0015631"(tubulin binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0014069"(postsynaptic density)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR036028|mint:P39688|rcsb pdb:3UF4|interpro:IPR036860|reactome:R-MMU-114604|reactome:R-MMU-1227986|reactome:R-MMU-1257604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2424491|reactome:R-MMU-373753|reactome:R-MMU-375165|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-75892|reactome:R-MMU-8866376|reactome:R-MMU-9032759|reactome:R-MMU-912631|refseq:NP_001116364.1|refseq:NP_001116365.1|refseq:NP_032080.2|refseq:XP_006512602.1|refseq:XP_006512603.1|refseq:XP_011241419.1|dip:DIP-198N - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:QVU98HrNOdxdJIzSvFWdhZ914MQ10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:Q8BFZ9 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-1635049|uniprotkb:Q8BML8|ensembl:ENSMUSP00000033873 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:erln2_mouse(display_long)|uniprotkb:Erlin2(gene name)|psi-mi:Erlin2(display_short)|uniprotkb:Spfh2(gene name synonym)|uniprotkb:Endoplasmic reticulum lipid raft-associated protein 2(gene name synonym)|uniprotkb:Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2(gene name synonym) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) refseq:NP_705820.1|refseq:XP_006509179.1|refseq:XP_006509180.1|ensembl:ENSMUSG00000031483(gene)|ensembl:ENSMUST00000033873(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|interpro:IPR001107(Band 7 protein)|interpro:IPR033294|interpro:IPR036013|mint:Q8BFZ9|reactome:R-MMU-382556 - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:/OxFugzl4zprvnZbqOGcXmUe3ao10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:F7B227 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-26446280|ensembl:ENSMUSP00000116992 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:f7b227_mouse(display_long)|uniprotkb:Ech1(gene name)|psi-mi:Ech1(display_short) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) ensembl:ENSMUSG00000053898(gene)|ensembl:ENSMUST00000132376(transcript)|interpro:IPR001753(Crotonase, core)|interpro:IPR014748(Crontonase, C-terminal)|interpro:IPR029045|mint:F7B227|go:"GO:0003824"(catalytic activity) - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:e/yESaXwPYIWT3C5E1t3yzk7RLE10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:P39053 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-397785|ensembl:ENSMUSP00000122679|uniprotkb:A2AN50|uniprotkb:A2AN51|uniprotkb:A2AN54|uniprotkb:A2AN55|uniprotkb:Q3UNM1|uniprotkb:Q5DTN7|uniprotkb:Q61358|uniprotkb:Q61359|uniprotkb:Q61360|uniprotkb:Q6PDM5|uniprotkb:Q8JZZ4|uniprotkb:Q9CSY7|uniprotkb:Q9QXX1 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:dyn1_mouse(display_long)|uniprotkb:Dnm1(gene name)|psi-mi:Dnm1(display_short)|uniprotkb:Dnm(gene name synonym)|uniprotkb:Kiaa4093(gene name synonym) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) refseq:NP_034195.2|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027417|interpro:IPR027741|interpro:IPR030381|mint:P39053|reactome:R-MMU-166016|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-2132295|reactome:R-MMU-437239|reactome:R-MMU-8856828|ensembl:ENSMUSG00000026825(gene)|ensembl:ENSMUST00000139624(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007032"(endosome organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030424"(axon)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043196"(varicosity)|go:"GO:0043209"(myelin sheath)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0061025"(membrane fusion)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901998"(toxin transport)|go:"GO:1903423"(positive regulation of synaptic vesicle recycling)|go:"GO:1904645"(response to amyloid-beta)|refseq:NP_001288666.1|refseq:XP_006497721.2|refseq:XP_006497722.2|refseq:XP_006497723.2|refseq:XP_006497724.2|refseq:XP_006497718.2|refseq:XP_017170817.1 - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:wtPz3gwyxU6tAgh5091LQpt099I10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:P12960 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-774808|uniprotkb:Q6NXV7|uniprotkb:Q8BR42|uniprotkb:Q8C6A0|ensembl:ENSMUSP00000000109|ensembl:ENSMUSP00000067842|ensembl:ENSMUSP00000133063 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:cntn1_mouse(display_long)|uniprotkb:Neural cell surface protein F3(gene name synonym)|uniprotkb:Cntn1(gene name)|psi-mi:Cntn1(display_short) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) refseq:NP_001153119.1|refseq:NP_001153120.1|refseq:NP_031753.1|refseq:XP_017171911.1|ensembl:ENSMUSG00000055022(gene)|ensembl:ENSMUST00000000109(transcript)|ensembl:ENSMUST00000068378(transcript)|ensembl:ENSMUST00000169825(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0021549"(cerebellum development)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0099025"(anchored component of postsynaptic membrane)|go:"GO:0099026"(anchored component of presynaptic membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|interpro:IPR036992|mint:P12960 - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:TftNvfwJlK/7DTczqiV/IzDxhOM10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:Q3UVR2 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-26446266 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:q3uvr2_mouse(display_long)|uniprotkb:Cntfr(gene name)|psi-mi:Cntfr(display_short) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) go:"GO:0004896"(cytokine receptor activity)|go:"GO:0016020"(membrane)|mint:Q3UVR2|interpro:IPR003961(Fibronectin, type III)|interpro:IPR036116|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2) - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:pyxkprZ8mJOtG6B0nanROBjTiHU10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:Q9Z1L5 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-770987|ensembl:ENSMUSP00000022567 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:ca2d3_mouse(display_long)|uniprotkb:Voltage-gated calcium channel subunit alpha-2/delta-3(gene name synonym)|uniprotkb:Cacna2d3(gene name)|psi-mi:Cacna2d3(display_short) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) refseq:NP_033915.1|ensembl:ENSMUSG00000021991(gene)|ensembl:ENSMUST00000022567(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0046872"(metal ion binding)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR013608(VWA N-terminal)|interpro:IPR013680(Voltage-dependent calcium channel, alpha-2/delta subunit, conserved region)|interpro:IPR036465|mint:Q9Z1L5|reactome:R-MMU-112308 - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:984OZ/kakEFWG7J/QJwVagioUEM10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:Q6PHS9 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-770977|uniprotkb:Q3TPT9|uniprotkb:Q3TSS6|uniprotkb:Q6REE3|uniprotkb:Q8C8R8|uniprotkb:Q8CHE9|uniprotkb:Q920H5|uniprotkb:Q920H6|uniprotkb:Q9EQG2|uniprotkb:Q9R142|uniprotkb:B2RY16|ensembl:ENSMUSP00000082173 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:ca2d2_mouse(display_long)|uniprotkb:Voltage-gated calcium channel subunit alpha-2/delta-2(gene name synonym)|uniprotkb:Protein ducky(gene name synonym)|uniprotkb:Cacna2d2(gene name)|psi-mi:Cacna2d2(display_short)|uniprotkb:Kiaa0558(gene name synonym) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) refseq:NP_001167518.1|refseq:NP_001167520.1|refseq:NP_001167521.1|refseq:NP_064659.2|refseq:XP_011241201.1|ensembl:ENSMUSG00000010066(gene)|ensembl:ENSMUST00000085092(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0055001"(muscle cell development)|go:"GO:0060024"(rhythmic synaptic transmission)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR013608(VWA N-terminal)|interpro:IPR013680(Voltage-dependent calcium channel, alpha-2/delta subunit, conserved region)|interpro:IPR036465|mint:Q6PHS9|reactome:R-MMU-112308|reactome:R-MMU-422356|reactome:R-MMU-5576892|reactome:R-MMU-5576893 - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:cB0cFE/l3UNx4IFmLR0fBTZR7s810090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:Q3TXB1 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-26446256 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:q3txb1_mouse(display_long)|uniprotkb:C1qa(gene name)|psi-mi:C1qa(display_short) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) go:"GO:0005576"(extracellular region)|go:"GO:0006958"(complement activation, classical pathway)|mint:Q3TXB1|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR037572|interpro:IPR008983(Tumour necrosis factor-like) - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:kGP0S0OYo6pBA1pJUAHnNF+rNyA10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:Q91XV3 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-772877|ensembl:ENSMUSP00000053943 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:basp1_mouse(display_long)|uniprotkb:Neuronal axonal membrane protein NAP-22(gene name synonym)|uniprotkb:22 kDa neuronal tissue-enriched acidic protein(gene name synonym)|uniprotkb:Basp1(gene name)|psi-mi:Basp1(display_short)|uniprotkb:Nap22(gene name synonym) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) refseq:NP_081671.1|ensembl:ENSMUSG00000045763(gene)|ensembl:ENSMUST00000058845(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030054"(cell junction)|go:"GO:0030426"(growth cone)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0072112"(glomerular visceral epithelial cell differentiation)|interpro:IPR008408(Brain acid soluble protein 1)|mint:Q91XV3|reactome:R-MMU-9035034 - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:dwUwWfxMdUr+bki6HEHeaEibNOQ10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:P62814 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-772655|uniprotkb:Q3U9Z0|uniprotkb:Q3UAW7|uniprotkb:Q3TG74|uniprotkb:Q3U7C8|uniprotkb:Q3TL62|uniprotkb:Q3TVK6|uniprotkb:Q3TWR0|uniprotkb:Q3U791|uniprotkb:O09045|uniprotkb:P50517|ensembl:ENSMUSP00000006435 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:vatb2_mouse(display_long)|uniprotkb:Vacuolar proton pump subunit B 2(gene name synonym)|uniprotkb:Endomembrane proton pump 58 kDa subunit(gene name synonym)|uniprotkb:Atp6v1b2(gene name)|psi-mi:Atp6v1b2(display_short)|uniprotkb:Atp6b2(gene name synonym)|uniprotkb:Vat2(gene name synonym) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) refseq:NP_031535.2|ensembl:ENSMUSG00000006273(gene)|ensembl:ENSMUST00000006435(transcript)|go:"GO:0000221"(vacuolar proton-transporting V-type ATPase, V1 domain)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0042470"(melanosome)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046034"(ATP metabolic process)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005723(ATPase, V1 complex, subunit B)|interpro:IPR020003|interpro:IPR022879|interpro:IPR027417|mint:P62814|reactome:R-MMU-1222556|reactome:R-MMU-77387|reactome:R-MMU-917977|reactome:R-MMU-9639288|reactome:R-MMU-983712 - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:cmFm/xe3iOTqmy849cfoi4XeG+A10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:P51863 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-769989|uniprotkb:Q54A57|uniprotkb:Q9QWJ2|ensembl:ENSMUSP00000013304 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:va0d1_mouse(display_long)|uniprotkb:Vacuolar proton pump subunit d 1(gene name synonym)|uniprotkb:V-ATPase AC39 subunit(gene name synonym)|uniprotkb:V-ATPase 40 kDa accessory protein(gene name synonym)|uniprotkb:P39(gene name synonym)|uniprotkb:Physophilin(gene name synonym)|uniprotkb:Atp6v0d1(gene name)|psi-mi:Atp6v0d1(display_short)|uniprotkb:Atp6d(gene name synonym) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) refseq:NP_038505.2|ensembl:ENSMUSG00000013160(gene)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005813"(centrosome)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007034"(vacuolar transport)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0007420"(brain development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033179"(proton-transporting V-type ATPase, V0 domain)|go:"GO:0033181"(plasma membrane proton-transporting V-type ATPase complex)|go:"GO:0036295"(cellular response to increased oxygen levels)|go:"GO:0043005"(neuron projection)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0060271"(cilium assembly)|interpro:IPR002843(ATPase, V0/A0 complex, subunit C/D)|interpro:IPR016727(ATPase, V0 complex, subunit D)|interpro:IPR035067|interpro:IPR036079|interpro:IPR044911|mint:P51863|reactome:R-MMU-1222556|reactome:R-MMU-77387|reactome:R-MMU-917977|reactome:R-MMU-9639288|reactome:R-MMU-983712|ensembl:ENSMUST00000013304(transcript) - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:XxeN6m831kNCB989OtmNfbjUvlo10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:Q1XID4 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-26446230 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:q1xid4_mouse(display_long)|uniprotkb:Atp6ap2(gene name)|psi-mi:Atp6ap2(display_short)|uniprotkb:"ATPase H(+)-transporting lysosomal-interacting protein 2"(gene name synonym)|uniprotkb:Renin receptor(gene name synonym)|uniprotkb:Renin/prorenin receptor(gene name synonym) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) go:"GO:0000421"(autophagosome membrane)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0021626"(central nervous system maturation)|go:"GO:0021903"(rostrocaudal neural tube patterning)|go:"GO:0032591"(dendritic spine membrane)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044297"(cell body)|go:"GO:0048069"(eye pigmentation)|go:"GO:0060323"(head morphogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|mint:Q1XID4|refseq:NP_081715.1|interpro:IPR012493(Renin receptor-like) - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:JcEUoAQ7OkE8KK+xHkaKGJ4/heg10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:B7XGA6 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-26446220 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:b7xga6_mouse(display_long)|uniprotkb:Alpl(gene name)|psi-mi:Alpl(display_short) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) go:"GO:0004035"(alkaline phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0031225"(anchored component of membrane)|mint:B7XGA6|interpro:IPR001952(Alkaline phosphatase)|interpro:IPR018299|interpro:IPR017850(Alkaline-phosphatase-like, core domain) - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:QemBXKFp9QQvR8gOEPZ5YIXgE0I10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:G3UYQ4 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-26446181|ensembl:ENSMUSP00000134177 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:g3uyq4_mouse(display_long)|uniprotkb:Ak9(gene name)|psi-mi:Ak9(display_short)|uniprotkb:Akd1(gene name synonym) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) ensembl:ENSMUSG00000091415(gene)|ensembl:ENSMUST00000173494(transcript)|go:"GO:0004017"(adenylate kinase activity)|go:"GO:0004550"(nucleoside diphosphate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0031965"(nuclear membrane)|go:"GO:0050145"(nucleoside monophosphate kinase activity)|go:"GO:0061508"(CDP phosphorylation)|go:"GO:0061565"(dAMP phosphorylation)|go:"GO:0061566"(CMP phosphorylation)|go:"GO:0061567"(dCMP phosphorylation)|go:"GO:0061568"(GDP phosphorylation)|go:"GO:0061569"(UDP phosphorylation)|go:"GO:0061570"(dCDP phosphorylation)|go:"GO:0061571"(TDP phosphorylation)|interpro:IPR000850(Adenylate kinase)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR027417|mint:G3UYQ4|reactome:R-MMU-499943|go:"GO:0006174"(dADP phosphorylation)|go:"GO:0006186"(dGDP phosphorylation)|go:"GO:0006756"(AMP phosphorylation)|go:"GO:0006757"(ATP generation from ADP) - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:qeyN4HoMcnmWFlWxWKBPrpzngbc10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:Q3ULT2 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-26446141 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:q3ult2_mouse(display_long)|uniprotkb:Actn4(gene name)|psi-mi:Actn4(display_short) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005903"(brush border)|mint:Q3ULT2|refseq:NP_068695.1|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR036872|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR018159|interpro:IPR002017(Spectrin repeat) - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:IeHeXy0Cx5E6ivN3b8IxESBlhJI10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:B2RRX1 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-26446129 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:b2rrx1_mouse(display_long)|uniprotkb:Actb(gene name)|psi-mi:Actb(display_short) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030957"(Tat protein binding)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045176"(apical protein localization)|go:"GO:0048870"(cell motility)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0070160"(tight junction)|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0072749"(cellular response to cytochalasin B)|go:"GO:0097433"(dense body)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150111"(regulation of transepithelial transport)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990904"(ribonucleoprotein complex)|mint:B2RRX1|refseq:NP_031419.1|interpro:IPR004000(Actin/actin-like)|interpro:IPR020902|interpro:IPR004001(Actin, conserved site)|interpro:IPR043129 - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:Hoge1B8Pn56kvbNTpkSLsQuHwRc10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P50897 uniprotkb:B7XGA6 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-26446220 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:b7xga6_mouse(display_long)|uniprotkb:Alpl(gene name)|psi-mi:Alpl(display_short) psi-mi:"MI:0096"(pull down) Sapir et al. (2018) imex:IM-28496|pubmed:30918483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26446811|imex:IM-28496-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) go:"GO:0004035"(alkaline phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0031225"(anchored component of membrane)|mint:B7XGA6|interpro:IPR001952(Alkaline phosphatase)|interpro:IPR018299|interpro:IPR017850(Alkaline-phosphatase-like, core domain) - - - figure legend:ST2|comment:"To identify PPT1 binding proteins, we affinity purified GFP-PPT1 binding proteins using brain lysates derived from Ppt1−/− or wild type in comparison with GFP proteins. The list includes peptides which were statistically significant either in lysates derived from wild type brains and/or in lysates derived from Ppt1−/− brains, for 96 of the peptides, protein symbols could be assigned (Supplementary Table S1). Overall, we identified 64 proteins as PPT1 interacting proteins"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/11/13 2020/11/16 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:QemBXKFp9QQvR8gOEPZ5YIXgE0I10090 rigid:MByhYFT+ba6//9DYb/7qSg/qeWs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry)