#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q5JU85	intact:EBI-16882364	intact:EBI-11028607|uniprotkb:B3KT97|uniprotkb:C7SDG1|uniprotkb:Q5JUX1|uniprotkb:O60275|uniprotkb:A0A1W2PQN3|ensembl:ENSP00000495726|ensembl:ENSP00000502054	-	psi-mi:iqec2_human(display_long)|uniprotkb:IQSEC2(gene name)|psi-mi:IQSEC2(display_short)|uniprotkb:KIAA0522(gene name synonym)	psi-mi:calm1_calm2_calm3_human(display_short)|psi-mi:EBI-16882364(display_long)|intact:CALM(author assigned name)	psi-mi:"MI:0096"(pull down)	Rogers et al. (2018)	imex:IM-28573|pubmed:30842726	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26564784|imex:IM-28573-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1304"(molecule set)	ensembl:ENST00000375365|ensembl:ENSP00000364514|ensembl:ENST00000639161|ensembl:ENSP00000491796|ensembl:ENSP00000495726|ensembl:ENSP00000502054|refseq:XP_016884848.1|refseq:NP_001104595.1|refseq:NP_055890.1|dip:DIP-59490N|refseq:NP_001230126.1|ensembl:ENSG00000124313(gene)|ensembl:ENST00000642864(transcript)|ensembl:ENST00000674510(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000904(SEC7-like)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023394|interpro:IPR033742|interpro:IPR035999|mint:Q5JU85|rcsb pdb:6FAE	uniprotkb:P62158(see-also)|uniprotkb:P0DP25(set member)|uniprotkb:P0DP23(set member)|uniprotkb:P0DP24(set member)	-	-	-	figure legend:Fig. 1B-C|comment:The binding of calmodulin to wild type and A350V IQSEC2 is increased by calcium.|agonist:"CHEBI:29108 - calcium(2+)"|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/15	2020/12/15	rogid:BbTUAk1bBeXX8YIOAfzURrpm1NU9606	-	-	false	mutation decreasing interaction strength:350-350|renilla luciferase protein tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:1220"(tag visualisation by luciferase assay)	psi-mi:"MI:1220"(tag visualisation by luciferase assay)
uniprotkb:Q5JU85	uniprotkb:P0DP23	intact:EBI-11028607|uniprotkb:B3KT97|uniprotkb:C7SDG1|uniprotkb:Q5JUX1|uniprotkb:O60275|uniprotkb:A0A1W2PQN3|ensembl:ENSP00000495726|ensembl:ENSP00000502054	intact:EBI-25817233|ensembl:ENSP00000349467|intact:EBI-28973196|uniprotkb:P02593|uniprotkb:P62158|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q13942|uniprotkb:Q53S29|uniprotkb:Q61379|uniprotkb:Q61380|uniprotkb:Q96HK3	psi-mi:iqec2_human(display_long)|uniprotkb:IQSEC2(gene name)|psi-mi:IQSEC2(display_short)|uniprotkb:KIAA0522(gene name synonym)	psi-mi:calm1_human(display_long)|uniprotkb:CALM1(gene name)|psi-mi:CALM1(display_short)|uniprotkb:CALM(gene name synonym)|uniprotkb:CAM(gene name synonym)|uniprotkb:CAM1(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Rogers et al. (2018)	imex:IM-28573|pubmed:30842726	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26564800|imex:IM-28573-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000375365|ensembl:ENSP00000364514|ensembl:ENST00000639161|ensembl:ENSP00000491796|ensembl:ENSP00000495726|ensembl:ENSP00000502054|refseq:XP_016884848.1|refseq:NP_001104595.1|refseq:NP_055890.1|dip:DIP-59490N|refseq:NP_001230126.1|ensembl:ENSG00000124313(gene)|ensembl:ENST00000642864(transcript)|ensembl:ENST00000674510(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000904(SEC7-like)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023394|interpro:IPR033742|interpro:IPR035999|mint:Q5JU85|rcsb pdb:6FAE	rcsb pdb:2I08|rcsb pdb:2JZI|rcsb pdb:2K0E|rcsb pdb:2K0F|rcsb pdb:2K0J|rcsb pdb:2K61|rcsb pdb:2KNE|rcsb pdb:2KUG|rcsb pdb:2KUH|rcsb pdb:2L53|rcsb pdb:2L7L|rcsb pdb:2LGF|rcsb pdb:2LL6|rcsb pdb:2LL7|rcsb pdb:2LQC|rcsb pdb:2LQP|rcsb pdb:2LV6|rcsb pdb:2M0J|rcsb pdb:2M0K|rcsb pdb:2M55|rcsb pdb:2MG5|rcsb pdb:2N27|rcsb pdb:2N6A|rcsb pdb:2N77|rcsb pdb:2N8J|rcsb pdb:2R28|rcsb pdb:2V01|rcsb pdb:2V02|rcsb pdb:2VAY|rcsb pdb:2HF5|rcsb pdb:2W73|rcsb pdb:2WEL|rcsb pdb:2X0G|go:"GO:0098901"(regulation of cardiac muscle cell action potential)|go:"GO:0140056"(organelle localization by membrane tethering)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1901842"(negative regulation of high voltage-gated calcium channel activity)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|go:"GO:1902494"(catalytic complex)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|go:"GO:1990456"(mitochondrion-endoplasmic reticulum membrane tethering)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:P0DP23|rcsb pdb:1AJI|rcsb pdb:1CDL|rcsb pdb:1CLL|rcsb pdb:1CTR|rcsb pdb:1IWQ|rcsb pdb:1J7O|rcsb pdb:1J7P|rcsb pdb:1K90|go:"GO:0097718"(disordered domain specific binding)|rcsb pdb:1K93|rcsb pdb:1L7Z|rcsb pdb:1LVC|ensembl:ENSG00000198668(gene)|ensembl:ENST00000356978(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0001975"(response to amphetamine)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030017"(sarcomere)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031432"(titin binding)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0031982"(vesicle)|go:"GO:0031997"(N-terminal myristoylation domain binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0043209"(myelin sheath)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:0090151"(establishment of protein localization to mitochondrial membrane)|go:"GO:0030672"(synaptic vesicle membrane)|rcsb pdb:1PK0|rcsb pdb:1S26|rcsb pdb:1SK6|rcsb pdb:1SW8|rcsb pdb:1UP5|rcsb pdb:1WRZ|rcsb pdb:1XFU|rcsb pdb:1XFV|rcsb pdb:1XFW|rcsb pdb:1XFX|rcsb pdb:1XFY|rcsb pdb:1XFZ|rcsb pdb:1Y6W|rcsb pdb:1YR5|rcsb pdb:1YRT|rcsb pdb:1YRU|rcsb pdb:1ZOT|rcsb pdb:1ZUZ|rcsb pdb:2BE6|rcsb pdb:1NKF|rcsb pdb:2F3Y|rcsb pdb:2F3Z|rcsb pdb:2Y4V|rcsb pdb:3DVE|rcsb pdb:3DVJ|rcsb pdb:3DVK|rcsb pdb:3DVM|rcsb pdb:3EWT|rcsb pdb:3EWV|rcsb pdb:3G43|rcsb pdb:3HR4|rcsb pdb:3J41|rcsb pdb:3O77|rcsb pdb:3O78|rcsb pdb:3OXQ|rcsb pdb:3SUI|rcsb pdb:3UCT|rcsb pdb:3UCW|rcsb pdb:3UCY|rcsb pdb:4BW7|rcsb pdb:4BW8|rcsb pdb:4BYF|rcsb pdb:4DCK|rcsb pdb:4DJC|rcsb pdb:4GOW|rcsb pdb:4JPZ|rcsb pdb:4JQ0|rcsb pdb:4L79|rcsb pdb:4LZX|rcsb pdb:4M1L|rcsb pdb:4OVN|rcsb pdb:4Q57|rcsb pdb:4Q5U|rcsb pdb:4UMO|rcsb pdb:4UPU|rcsb pdb:4V0C|rcsb pdb:5COC|rcsb pdb:3BYA|rcsb pdb:5DBR|rcsb pdb:5DOW|rcsb pdb:5DSU|rcsb pdb:5GGM|rcsb pdb:5I0I|rcsb pdb:5J03|rcsb pdb:5J8H|rcsb pdb:5JQA|rcsb pdb:5JTH|rcsb pdb:5K7L|rcsb pdb:5K8Q|rcsb pdb:5OEO|rcsb pdb:5TP5|rcsb pdb:5TP6|rcsb pdb:5V02|rcsb pdb:5V03|rcsb pdb:5V7X|rcsb pdb:5WBX|rcsb pdb:5WC5|rcsb pdb:6B8L|rcsb pdb:6B8M|rcsb pdb:6B8N|rcsb pdb:6B8P|rcsb pdb:6B8Q|rcsb pdb:6BUT|rcsb pdb:6C1D|rcsb pdb:6C1G|rcsb pdb:6C1H|rcsb pdb:6CNM|rcsb pdb:6CNN|rcsb pdb:6CNO|rcsb pdb:6DAD|rcsb pdb:6DAE|rcsb pdb:6DAF|rcsb pdb:6DAH|rcsb pdb:6E2F|rcsb pdb:6E2G|rcsb pdb:6EEB|rcsb pdb:6FEG|rcsb pdb:6FEH|rcsb pdb:6GDK|rcsb pdb:6GDL|rcsb pdb:6HCS|rcsb pdb:6HR1|rcsb pdb:6JI8|rcsb pdb:6JII|rcsb pdb:6JIU|rcsb pdb:6JIY|rcsb pdb:6JRS|rcsb pdb:6JV2|rcsb pdb:6K4K|rcsb pdb:6K4L|rcsb pdb:6K4R|rcsb pdb:6M2W|rcsb pdb:6M7H|rcsb pdb:6MUD|rcsb pdb:6MUE|rcsb pdb:6N5W|rcsb pdb:6O5G|rcsb pdb:6OS4|rcsb pdb:6PAW|rcsb pdb:6PBX|rcsb pdb:6PBY|rcsb pdb:6U39|rcsb pdb:6U3A|rcsb pdb:6U3B|rcsb pdb:6U3D|rcsb pdb:6UZZ|rcsb pdb:6V00|rcsb pdb:6V01|rcsb pdb:6X32|rcsb pdb:6X33|rcsb pdb:6X35|rcsb pdb:6X36|rcsb pdb:6XXX|rcsb pdb:6XY3|rcsb pdb:6XYR|rcsb pdb:6Y4P|rcsb pdb:6Y94|rcsb pdb:6Y95|rcsb pdb:6YNS|rcsb pdb:6YNU|rcsb pdb:6ZBI|rcsb pdb:7KL5|reactome:R-HSA-111932|reactome:R-HSA-111933|reactome:R-HSA-111957|reactome:R-HSA-111997|reactome:R-HSA-114608|reactome:R-HSA-1445148|reactome:R-HSA-442982|reactome:R-HSA-445355|reactome:R-HSA-451308|reactome:R-HSA-1474151|reactome:R-HSA-5210891|reactome:R-HSA-5218920|reactome:R-HSA-5218921|reactome:R-HSA-163615|reactome:R-HSA-180024|reactome:R-HSA-5576892|reactome:R-HSA-1855204|reactome:R-HSA-2025928|reactome:R-HSA-5578775|reactome:R-HSA-5607763|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-203615|reactome:R-HSA-2151201|reactome:R-HSA-2514859|reactome:R-HSA-5673000|reactome:R-HSA-2672351|reactome:R-HSA-5673001|reactome:R-HSA-6802946|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-2871809|reactome:R-HSA-4086398|reactome:R-HSA-70221|reactome:R-HSA-8876725|reactome:R-HSA-9009391|reactome:R-HSA-418359|reactome:R-HSA-425561|reactome:R-HSA-438066|reactome:R-HSA-442720|reactome:R-HSA-9022535|reactome:R-HSA-9022692|reactome:R-HSA-936837|reactome:R-HSA-9617324|reactome:R-HSA-9619229|reactome:R-HSA-9619483|reactome:R-HSA-9620244|reactome:R-HSA-9648002|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664323|reactome:R-HSA-983695|reactome:R-HSA-442729|refseq:NP_001316851.1|refseq:NP_001734.1|refseq:NP_005175.2|refseq:NP_008819.1	-	-	-	figure legend:Fig. 2|comment:The binding of calmodulin to wild type and A350V IQSEC2 is increased by calcium.|agonist:"CHEBI:29108 - calcium(2+)"|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/12/15	2020/12/15	rogid:BbTUAk1bBeXX8YIOAfzURrpm1NU9606	rogid:tTYcOd9bOh211njZVz7cYVybAMQ9606	rigid:yT+ST7BWmrKo2U9idx8Hn9pyI5I	false	mutation disrupting interaction strength:350-350|renilla luciferase protein tag:n-n|ha tag:n-n|mutation disrupting interaction strength:359-359|mutation disrupting interaction strength:354-355,359-359	flag tag:c-c	-	-	psi-mi:"MI:1220"(tag visualisation by luciferase assay)	psi-mi:"MI:1220"(tag visualisation by luciferase assay)