#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P83105	uniprotkb:P33151-1	intact:EBI-21776319|uniprotkb:Q542Z4|uniprotkb:Q6PF13|ensembl:ENSP00000305919	intact:EBI-25652861|ensembl:ENSP00000497290|ensembl:ENSP00000344115	psi-mi:htra4_human(display_long)|uniprotkb:High-temperature requirement factor A4(gene name synonym)|uniprotkb:HTRA4(gene name)|psi-mi:HTRA4(display_short)	psi-mi:p33151-1(display_long)|uniprotkb:CDH5(gene name)|psi-mi:CDH5(display_short)|uniprotkb:7B4 antigen(gene name synonym)|uniprotkb:Vascular endothelial cadherin(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Tseng et al. (2019)	imex:IM-28107|pubmed:30638949	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25652851|imex:IM-28107-1	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_710159.1|ensembl:ENSG00000169495(gene)|ensembl:ENST00000302495(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058	ensembl:ENSG00000179776(gene)|ensembl:ENST00000341529(transcript)|ensembl:ENST00000649567(transcript)|intact:EBI-2903122(isoform-parent)	go:"GO:0004252"(serine-type endopeptidase activity)	-	-	figure legend:1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/13	2020/06/18	rogid:MBtL5intF+eVkUYKHFfHJFTCoJo9606	rogid:HzQQYMIWIEnMktuJKjc45wFfEDk9606	rigid:bai2ExIx2rNhXaeQK2zYsNQriVE	false	-	his tag:c-c|sufficient binding region:48-599	-	2	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)