#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P60880 uniprotkb:Q9NRW1 intact:EBI-524785|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|uniprotkb:B2RAU4|uniprotkb:Q53EM2|uniprotkb:Q5U0B5|uniprotkb:D3DW16|uniprotkb:D3DW17|ensembl:ENSP00000254976 intact:EBI-1760079|uniprotkb:D3DND3|uniprotkb:B2R5Z9|uniprotkb:Q92929|uniprotkb:B7Z337|ensembl:ENSP00000285208|ensembl:ENSP00000437797 psi-mi:snp25_human(display_long)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym)|uniprotkb:SNAP25(gene name)|psi-mi:SNAP25(display_short)|uniprotkb:SNAP(gene name synonym) psi-mi:rab6b_human(display_long)|uniprotkb:RAB6B(gene name)|psi-mi:RAB6B(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ramos-Miguel et al. (2019) pubmed:30610939|imex:IM-28601 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26578093|imex:IM-28601-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005260865.1|refseq:XP_016883510.1|refseq:NP_003072.2|refseq:NP_570824.1|ensembl:ENSG00000132639(gene)|ensembl:ENST00000254976(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030426"(growth cone)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:P60880|rcsb pdb:1KIL|rcsb pdb:1XTG|rcsb pdb:2N1T|rcsb pdb:3DDA|rcsb pdb:3DDB|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|rcsb pdb:3ZUR|rcsb pdb:5W7I|rcsb pdb:5W7J|rcsb pdb:6JLH|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-422356|reactome:R-HSA-449836|reactome:R-HSA-5250968|reactome:R-HSA-5250971|reactome:R-HSA-5250992|reactome:R-HSA-6798695|reactome:R-HSA-888590|reactome:R-HSA-9662360|refseq:XP_016883511.1|refseq:NP_001309831.1|refseq:NP_001309832.1|refseq:NP_001309833.1|refseq:NP_001309834.1|refseq:NP_001309835.1|refseq:NP_001309836.1|refseq:NP_001309837.1|refseq:NP_001309838.1|refseq:NP_001309839.1|dip:DIP-34554N refseq:XP_011511195.1|refseq:NP_057661.3|ensembl:ENSG00000154917(gene)|ensembl:ENST00000285208(transcript)|ensembl:ENST00000543906(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031489"(myosin V binding)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0098793"(presynapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:Q9NRW1|rcsb pdb:2E9S|rcsb pdb:2FE4|rcsb pdb:2FFQ|reactome:R-HSA-6811436|reactome:R-HSA-6811440|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198 - - - figure legend:ST2 ST3|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-brain-caudate_nucleus)|taxid:9606(Human brain, caudate nuclear region) - 2020/12/30 2021/01/05 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs9606 rogid:GmhjkLknjr8fxoUBxNx5ak5S/hQ9606 rigid:mveF/eKKR/8+XTujVjV5bTZxTE8 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P60880 uniprotkb:Q13642 intact:EBI-524785|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|uniprotkb:B2RAU4|uniprotkb:Q53EM2|uniprotkb:Q5U0B5|uniprotkb:D3DW16|uniprotkb:D3DW17|ensembl:ENSP00000254976 intact:EBI-912547|intact:EBI-1052757|uniprotkb:B7Z5T4|uniprotkb:B7Z793|uniprotkb:O95212|uniprotkb:Q13230|uniprotkb:Q13645|uniprotkb:Q5JXI7|uniprotkb:Q5M7Y6|uniprotkb:Q6IB30|uniprotkb:Q9NZ40|uniprotkb:Q9UKZ8|uniprotkb:Q9Y630|ensembl:ENSP00000377710|ensembl:ENSP00000498684 psi-mi:snp25_human(display_long)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym)|uniprotkb:SNAP25(gene name)|psi-mi:SNAP25(display_short)|uniprotkb:SNAP(gene name synonym) psi-mi:fhl1_human(display_long)|uniprotkb:FHL1(gene name)|psi-mi:FHL1(display_short)|uniprotkb:SLIM1(gene name synonym)|uniprotkb:Skeletal muscle LIM-protein 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ramos-Miguel et al. (2019) pubmed:30610939|imex:IM-28601 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26578093|imex:IM-28601-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005260865.1|refseq:XP_016883510.1|refseq:NP_003072.2|refseq:NP_570824.1|ensembl:ENSG00000132639(gene)|ensembl:ENST00000254976(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030426"(growth cone)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:P60880|rcsb pdb:1KIL|rcsb pdb:1XTG|rcsb pdb:2N1T|rcsb pdb:3DDA|rcsb pdb:3DDB|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|rcsb pdb:3ZUR|rcsb pdb:5W7I|rcsb pdb:5W7J|rcsb pdb:6JLH|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-422356|reactome:R-HSA-449836|reactome:R-HSA-5250968|reactome:R-HSA-5250971|reactome:R-HSA-5250992|reactome:R-HSA-6798695|reactome:R-HSA-888590|reactome:R-HSA-9662360|refseq:XP_016883511.1|refseq:NP_001309831.1|refseq:NP_001309832.1|refseq:NP_001309833.1|refseq:NP_001309834.1|refseq:NP_001309835.1|refseq:NP_001309836.1|refseq:NP_001309837.1|refseq:NP_001309838.1|refseq:NP_001309839.1|dip:DIP-34554N refseq:XP_006724807.1|refseq:XP_006724808.1|refseq:XP_006724809.1|refseq:XP_006724810.1|refseq:NP_001153172.1|refseq:NP_001153176.1|refseq:NP_001161291.1|refseq:NP_001440.2|refseq:NP_001153171.1|refseq:NP_001153173.1|refseq:NP_001153174.1|refseq:NP_001153175.1|refseq:XP_016884846.1|ensembl:ENSG00000022267(gene)|ensembl:ENST00000394155(transcript)|ensembl:ENST00000651089(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007517"(muscle organ development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010972"(negative regulation of G2/M transition of mitotic cell cycle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046872"(metal ion binding)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR042997|mint:Q13642|rcsb pdb:1X63|rcsb pdb:2CUP|rcsb pdb:2CUR|rcsb pdb:2EGQ - - - figure legend:ST2 ST3|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-brain-caudate_nucleus)|taxid:9606(Human brain, caudate nuclear region) - 2020/12/30 2021/01/05 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs9606 rogid:KZpPO3Pymj2oTCtX1//adbOZH+Y9606 rigid:mveF/eKKR/8+XTujVjV5bTZxTE8 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P60880 uniprotkb:Q9UL88 intact:EBI-524785|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|uniprotkb:B2RAU4|uniprotkb:Q53EM2|uniprotkb:Q5U0B5|uniprotkb:D3DW16|uniprotkb:D3DW17|ensembl:ENSP00000254976 intact:EBI-26578085 psi-mi:snp25_human(display_long)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym)|uniprotkb:SNAP25(gene name)|psi-mi:SNAP25(display_short)|uniprotkb:SNAP(gene name synonym) psi-mi:q9ul88_human(display_long) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ramos-Miguel et al. (2019) pubmed:30610939|imex:IM-28601 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26578093|imex:IM-28601-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005260865.1|refseq:XP_016883510.1|refseq:NP_003072.2|refseq:NP_570824.1|ensembl:ENSG00000132639(gene)|ensembl:ENST00000254976(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030426"(growth cone)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:P60880|rcsb pdb:1KIL|rcsb pdb:1XTG|rcsb pdb:2N1T|rcsb pdb:3DDA|rcsb pdb:3DDB|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|rcsb pdb:3ZUR|rcsb pdb:5W7I|rcsb pdb:5W7J|rcsb pdb:6JLH|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-422356|reactome:R-HSA-449836|reactome:R-HSA-5250968|reactome:R-HSA-5250971|reactome:R-HSA-5250992|reactome:R-HSA-6798695|reactome:R-HSA-888590|reactome:R-HSA-9662360|refseq:XP_016883511.1|refseq:NP_001309831.1|refseq:NP_001309832.1|refseq:NP_001309833.1|refseq:NP_001309834.1|refseq:NP_001309835.1|refseq:NP_001309836.1|refseq:NP_001309837.1|refseq:NP_001309838.1|refseq:NP_001309839.1|dip:DIP-34554N mint:Q9UL88|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set) - - - figure legend:ST2 ST3|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-brain-caudate_nucleus)|taxid:9606(Human brain, caudate nuclear region) - 2020/12/30 2021/01/05 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs9606 rogid:UCTjiBxc29VwtFV3OtE3sfZc3QM9606 rigid:mveF/eKKR/8+XTujVjV5bTZxTE8 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P60880 uniprotkb:Q9NP29 intact:EBI-524785|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|uniprotkb:B2RAU4|uniprotkb:Q53EM2|uniprotkb:Q5U0B5|uniprotkb:D3DW16|uniprotkb:D3DW17|ensembl:ENSP00000254976 intact:EBI-26578080 psi-mi:snp25_human(display_long)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym)|uniprotkb:SNAP25(gene name)|psi-mi:SNAP25(display_short)|uniprotkb:SNAP(gene name synonym) psi-mi:q9np29_human(display_long) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ramos-Miguel et al. (2019) pubmed:30610939|imex:IM-28601 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26578093|imex:IM-28601-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005260865.1|refseq:XP_016883510.1|refseq:NP_003072.2|refseq:NP_570824.1|ensembl:ENSG00000132639(gene)|ensembl:ENST00000254976(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030426"(growth cone)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:P60880|rcsb pdb:1KIL|rcsb pdb:1XTG|rcsb pdb:2N1T|rcsb pdb:3DDA|rcsb pdb:3DDB|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|rcsb pdb:3ZUR|rcsb pdb:5W7I|rcsb pdb:5W7J|rcsb pdb:6JLH|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-422356|reactome:R-HSA-449836|reactome:R-HSA-5250968|reactome:R-HSA-5250971|reactome:R-HSA-5250992|reactome:R-HSA-6798695|reactome:R-HSA-888590|reactome:R-HSA-9662360|refseq:XP_016883511.1|refseq:NP_001309831.1|refseq:NP_001309832.1|refseq:NP_001309833.1|refseq:NP_001309834.1|refseq:NP_001309835.1|refseq:NP_001309836.1|refseq:NP_001309837.1|refseq:NP_001309838.1|refseq:NP_001309839.1|dip:DIP-34554N mint:Q9NP29|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold) - - - figure legend:ST2 ST3|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-brain-caudate_nucleus)|taxid:9606(Human brain, caudate nuclear region) - 2020/12/30 2021/01/05 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs9606 rogid:Mvj6PnzX9hmmqTRCina6swtV0+U9606 rigid:mveF/eKKR/8+XTujVjV5bTZxTE8 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P60880 uniprotkb:P05026 intact:EBI-524785|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|uniprotkb:B2RAU4|uniprotkb:Q53EM2|uniprotkb:Q5U0B5|uniprotkb:D3DW16|uniprotkb:D3DW17|ensembl:ENSP00000254976 intact:EBI-714630|ensembl:ENSP00000356789|ensembl:ENSP00000356790|uniprotkb:Q5TGZ3 psi-mi:snp25_human(display_long)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym)|uniprotkb:SNAP25(gene name)|psi-mi:SNAP25(display_short)|uniprotkb:SNAP(gene name synonym) psi-mi:at1b1_human(display_long)|uniprotkb:Sodium/potassium-dependent ATPase subunit beta-1(gene name synonym)|uniprotkb:ATP1B1(gene name)|psi-mi:ATP1B1(display_short)|uniprotkb:ATP1B(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ramos-Miguel et al. (2019) pubmed:30610939|imex:IM-28601 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26578093|imex:IM-28601-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005260865.1|refseq:XP_016883510.1|refseq:NP_003072.2|refseq:NP_570824.1|ensembl:ENSG00000132639(gene)|ensembl:ENST00000254976(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030426"(growth cone)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:P60880|rcsb pdb:1KIL|rcsb pdb:1XTG|rcsb pdb:2N1T|rcsb pdb:3DDA|rcsb pdb:3DDB|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|rcsb pdb:3ZUR|rcsb pdb:5W7I|rcsb pdb:5W7J|rcsb pdb:6JLH|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-422356|reactome:R-HSA-449836|reactome:R-HSA-5250968|reactome:R-HSA-5250971|reactome:R-HSA-5250992|reactome:R-HSA-6798695|reactome:R-HSA-888590|reactome:R-HSA-9662360|refseq:XP_016883511.1|refseq:NP_001309831.1|refseq:NP_001309832.1|refseq:NP_001309833.1|refseq:NP_001309834.1|refseq:NP_001309835.1|refseq:NP_001309836.1|refseq:NP_001309837.1|refseq:NP_001309838.1|refseq:NP_001309839.1|dip:DIP-34554N ensembl:ENSG00000143153(gene)|ensembl:ENST00000367815(transcript)|ensembl:ENST00000367816(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005391"("P-type sodium:potassium-exchanging transporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005890"("sodium:potassium-exchanging ATPase complex")|go:"GO:0005901"(caveola)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030315"(T-tubule)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031090"(organelle membrane)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0035725"(sodium ion transmembrane transport)|interpro:IPR015565(Sodium/Potassium-Dependent ATPase Beta-1 Subunit)|interpro:IPR038702|mint:P05026|reactome:R-HSA-210991|reactome:R-HSA-5578775|reactome:R-HSA-936837|reactome:R-HSA-9679191|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086009"(membrane repolarization)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1903278"(positive regulation of sodium ion export across plasma membrane)|go:"GO:1903281"("positive regulation of calcium:sodium antiporter activity")|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000402(ATPase, P-type cation exchange, beta subunit)|go:"GO:0036126"(sperm flagellum)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0044861"(protein transport into plasma membrane raft)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|refseq:NP_001668.1 - - - figure legend:ST2 ST3|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-brain-caudate_nucleus)|taxid:9606(Human brain, caudate nuclear region) - 2020/12/30 2021/01/05 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs9606 rogid:kE/mTDRgwTdf/AWUD0ZFpPN4FkE9606 rigid:mveF/eKKR/8+XTujVjV5bTZxTE8 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P60880 uniprotkb:P06576 intact:EBI-524785|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|uniprotkb:B2RAU4|uniprotkb:Q53EM2|uniprotkb:Q5U0B5|uniprotkb:D3DW16|uniprotkb:D3DW17|ensembl:ENSP00000254976 intact:EBI-356231|ensembl:ENSP00000262030|uniprotkb:Q14283|uniprotkb:A8K4X0|intact:EBI-2322803 psi-mi:snp25_human(display_long)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym)|uniprotkb:SNAP25(gene name)|psi-mi:SNAP25(display_short)|uniprotkb:SNAP(gene name synonym) psi-mi:atpb_human(display_long)|uniprotkb:ATP5F1B(gene name)|psi-mi:ATP5F1B(display_short)|uniprotkb:ATP synthase F1 subunit beta(gene name synonym)|uniprotkb:ATP5B(gene name synonym)|uniprotkb:ATPMB(gene name synonym)|uniprotkb:ATPSB(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ramos-Miguel et al. (2019) pubmed:30610939|imex:IM-28601 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26578093|imex:IM-28601-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005260865.1|refseq:XP_016883510.1|refseq:NP_003072.2|refseq:NP_570824.1|ensembl:ENSG00000132639(gene)|ensembl:ENST00000254976(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030426"(growth cone)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:P60880|rcsb pdb:1KIL|rcsb pdb:1XTG|rcsb pdb:2N1T|rcsb pdb:3DDA|rcsb pdb:3DDB|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|rcsb pdb:3ZUR|rcsb pdb:5W7I|rcsb pdb:5W7J|rcsb pdb:6JLH|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-422356|reactome:R-HSA-449836|reactome:R-HSA-5250968|reactome:R-HSA-5250971|reactome:R-HSA-5250992|reactome:R-HSA-6798695|reactome:R-HSA-888590|reactome:R-HSA-9662360|refseq:XP_016883511.1|refseq:NP_001309831.1|refseq:NP_001309832.1|refseq:NP_001309833.1|refseq:NP_001309834.1|refseq:NP_001309835.1|refseq:NP_001309836.1|refseq:NP_001309837.1|refseq:NP_001309838.1|refseq:NP_001309839.1|dip:DIP-34554N ensembl:ENSG00000110955(gene)|ensembl:ENST00000262030(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005754"(mitochondrial proton-transporting ATP synthase, catalytic core)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005722(ATPase, F1 complex, beta subunit)|interpro:IPR020003|interpro:IPR024034|interpro:IPR027417|interpro:IPR036121|mint:P06576|reactome:R-HSA-1268020|reactome:R-HSA-163210|reactome:R-HSA-2151201|reactome:R-HSA-8949613|go:"GO:0070062"(extracellular exosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045259"(proton-transporting ATP synthase complex)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0051453"(regulation of intracellular pH)|refseq:NP_001677.2 - - - figure legend:ST2 ST3|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-brain-caudate_nucleus)|taxid:9606(Human brain, caudate nuclear region) - 2020/12/30 2021/01/05 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs9606 rogid:oLPUvG1tQkkzxzeAG6R0ZkZF+eg9606 rigid:mveF/eKKR/8+XTujVjV5bTZxTE8 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P60880 uniprotkb:Q59EP4 intact:EBI-524785|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|uniprotkb:B2RAU4|uniprotkb:Q53EM2|uniprotkb:Q5U0B5|uniprotkb:D3DW16|uniprotkb:D3DW17|ensembl:ENSP00000254976 intact:EBI-26578072 psi-mi:snp25_human(display_long)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym)|uniprotkb:SNAP25(gene name)|psi-mi:SNAP25(display_short)|uniprotkb:SNAP(gene name synonym) psi-mi:q59ep4_human(display_long) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ramos-Miguel et al. (2019) pubmed:30610939|imex:IM-28601 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26578093|imex:IM-28601-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005260865.1|refseq:XP_016883510.1|refseq:NP_003072.2|refseq:NP_570824.1|ensembl:ENSG00000132639(gene)|ensembl:ENST00000254976(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030426"(growth cone)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:P60880|rcsb pdb:1KIL|rcsb pdb:1XTG|rcsb pdb:2N1T|rcsb pdb:3DDA|rcsb pdb:3DDB|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|rcsb pdb:3ZUR|rcsb pdb:5W7I|rcsb pdb:5W7J|rcsb pdb:6JLH|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-422356|reactome:R-HSA-449836|reactome:R-HSA-5250968|reactome:R-HSA-5250971|reactome:R-HSA-5250992|reactome:R-HSA-6798695|reactome:R-HSA-888590|reactome:R-HSA-9662360|refseq:XP_016883511.1|refseq:NP_001309831.1|refseq:NP_001309832.1|refseq:NP_001309833.1|refseq:NP_001309834.1|refseq:NP_001309835.1|refseq:NP_001309836.1|refseq:NP_001309837.1|refseq:NP_001309838.1|refseq:NP_001309839.1|dip:DIP-34554N go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|mint:Q59EP4|interpro:IPR027417|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR001806(Ras GTPase) - - - figure legend:ST2 ST3|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-brain-caudate_nucleus)|taxid:9606(Human brain, caudate nuclear region) - 2020/12/30 2021/01/05 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs9606 rogid:sARTLcbgWQH/LaaX8eRvYjnz5yU9606 rigid:mveF/eKKR/8+XTujVjV5bTZxTE8 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P60880 uniprotkb:P46821 intact:EBI-524785|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|uniprotkb:B2RAU4|uniprotkb:Q53EM2|uniprotkb:Q5U0B5|uniprotkb:D3DW16|uniprotkb:D3DW17|ensembl:ENSP00000254976 intact:EBI-764611|uniprotkb:A2BDK5|ensembl:ENSP00000296755 psi-mi:snp25_human(display_long)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym)|uniprotkb:SNAP25(gene name)|psi-mi:SNAP25(display_short)|uniprotkb:SNAP(gene name synonym) psi-mi:map1b_human(display_long)|uniprotkb:MAP1B(gene name)|psi-mi:MAP1B(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ramos-Miguel et al. (2019) pubmed:30610939|imex:IM-28601 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26578093|imex:IM-28601-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005260865.1|refseq:XP_016883510.1|refseq:NP_003072.2|refseq:NP_570824.1|ensembl:ENSG00000132639(gene)|ensembl:ENST00000254976(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030426"(growth cone)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:P60880|rcsb pdb:1KIL|rcsb pdb:1XTG|rcsb pdb:2N1T|rcsb pdb:3DDA|rcsb pdb:3DDB|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|rcsb pdb:3ZUR|rcsb pdb:5W7I|rcsb pdb:5W7J|rcsb pdb:6JLH|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-422356|reactome:R-HSA-449836|reactome:R-HSA-5250968|reactome:R-HSA-5250971|reactome:R-HSA-5250992|reactome:R-HSA-6798695|reactome:R-HSA-888590|reactome:R-HSA-9662360|refseq:XP_016883511.1|refseq:NP_001309831.1|refseq:NP_001309832.1|refseq:NP_001309833.1|refseq:NP_001309834.1|refseq:NP_001309835.1|refseq:NP_001309836.1|refseq:NP_001309837.1|refseq:NP_001309838.1|refseq:NP_001309839.1|dip:DIP-34554N refseq:NP_005900.2|dip:DIP-33474N|ensembl:ENSG00000131711(gene)|ensembl:ENST00000296755(transcript)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001764"(neuron migration)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007409"(axonogenesis)|go:"GO:0007416"(synapse assembly)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0009987"(cellular process)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0014012"(peripheral nervous system axon regeneration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016358"(dendrite development)|go:"GO:0021700"(developmental maturation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031114"(regulation of microtubule depolymerization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0032355"(response to estradiol)|go:"GO:0032387"(negative regulation of intracellular transport)|go:"GO:0033189"(response to vitamin A)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042493"|go:"GO:0043025"(neuronal cell body)|go:"GO:0043196"(varicosity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0017085"(response to insecticide)|go:"GO:0045202"(synapse)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0051915"(induction of synaptic plasticity by chemical substance)|go:"GO:0061162"(establishment of monopolar cell polarity)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0097440"(apical dendrite)|go:"GO:0097441"(basal dendrite)|go:"GO:0097457"(hippocampal mossy fiber)|interpro:IPR000102(Neuraxin/MAP1B repeat)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR027321|mint:P46821|interpro:IPR026074 - - - figure legend:ST2 ST3|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-brain-caudate_nucleus)|taxid:9606(Human brain, caudate nuclear region) - 2020/12/30 2021/01/05 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs9606 rogid:uSRzrWaYU/dmkItUkCK4zex+/TM9606 rigid:mveF/eKKR/8+XTujVjV5bTZxTE8 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P60880 uniprotkb:P25705 intact:EBI-524785|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|uniprotkb:B2RAU4|uniprotkb:Q53EM2|uniprotkb:Q5U0B5|uniprotkb:D3DW16|uniprotkb:D3DW17|ensembl:ENSP00000254976 intact:EBI-351437|uniprotkb:Q53XX6|uniprotkb:Q8IXV2|uniprotkb:Q96FB4|uniprotkb:Q96HW2|uniprotkb:Q96IR6|uniprotkb:Q9BTV8|intact:EBI-11032691|uniprotkb:A8K092|uniprotkb:B4DY56|uniprotkb:K7ENP3|ensembl:ENSP00000282050|ensembl:ENSP00000381736 psi-mi:snp25_human(display_long)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym)|uniprotkb:SNAP25(gene name)|psi-mi:SNAP25(display_short)|uniprotkb:SNAP(gene name synonym) psi-mi:atpa_human(display_long)|uniprotkb:ATP5F1A(gene name)|psi-mi:ATP5F1A(display_short)|uniprotkb:ATP synthase F1 subunit alpha(gene name synonym)|uniprotkb:ATP5A(gene name synonym)|uniprotkb:ATP5A1(gene name synonym)|uniprotkb:ATP5AL2(gene name synonym)|uniprotkb:ATPM(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ramos-Miguel et al. (2019) pubmed:30610939|imex:IM-28601 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26578093|imex:IM-28601-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005260865.1|refseq:XP_016883510.1|refseq:NP_003072.2|refseq:NP_570824.1|ensembl:ENSG00000132639(gene)|ensembl:ENST00000254976(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030426"(growth cone)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:P60880|rcsb pdb:1KIL|rcsb pdb:1XTG|rcsb pdb:2N1T|rcsb pdb:3DDA|rcsb pdb:3DDB|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|rcsb pdb:3ZUR|rcsb pdb:5W7I|rcsb pdb:5W7J|rcsb pdb:6JLH|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-422356|reactome:R-HSA-449836|reactome:R-HSA-5250968|reactome:R-HSA-5250971|reactome:R-HSA-5250992|reactome:R-HSA-6798695|reactome:R-HSA-888590|reactome:R-HSA-9662360|refseq:XP_016883511.1|refseq:NP_001309831.1|refseq:NP_001309832.1|refseq:NP_001309833.1|refseq:NP_001309834.1|refseq:NP_001309835.1|refseq:NP_001309836.1|refseq:NP_001309837.1|refseq:NP_001309838.1|refseq:NP_001309839.1|dip:DIP-34554N refseq:NP_001244263.1|refseq:NP_001001937.1|refseq:NP_004037.1|refseq:NP_001001935.1|refseq:NP_001244264.1|dip:DIP-32871N|ensembl:ENSG00000152234(gene)|ensembl:ENST00000282050(transcript)|ensembl:ENST00000398752(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005754"(mitochondrial proton-transporting ATP synthase, catalytic core)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0043531"(ADP binding)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045259"(proton-transporting ATP synthase complex)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR000793(ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005294(ATPase, F1 complex, alpha subunit)|interpro:IPR020003|interpro:IPR023366|interpro:IPR027417|interpro:IPR033732|interpro:IPR036121|interpro:IPR038376|mint:P25705|reactome:R-HSA-1268020|reactome:R-HSA-163210|reactome:R-HSA-8949613 - - - figure legend:ST2 ST3|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-brain-caudate_nucleus)|taxid:9606(Human brain, caudate nuclear region) - 2020/12/30 2021/01/05 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs9606 rogid:Sy/Ii5ea+ilCKGBnIEMn133Vogc9606 rigid:mveF/eKKR/8+XTujVjV5bTZxTE8 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P60880 uniprotkb:P62820 intact:EBI-524785|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|uniprotkb:B2RAU4|uniprotkb:Q53EM2|uniprotkb:Q5U0B5|uniprotkb:D3DW16|uniprotkb:D3DW17|ensembl:ENSP00000254976 intact:EBI-716845|uniprotkb:Q96N61|uniprotkb:Q9Y3T2|uniprotkb:P11476|uniprotkb:Q6FIE7|ensembl:ENSP00000387286|ensembl:ENSP00000497078 psi-mi:snp25_human(display_long)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym)|uniprotkb:SNAP25(gene name)|psi-mi:SNAP25(display_short)|uniprotkb:SNAP(gene name synonym) psi-mi:rab1a_human(display_long)|uniprotkb:YPT1-related protein(gene name synonym)|uniprotkb:RAB1A(gene name)|psi-mi:RAB1A(display_short)|uniprotkb:RAB1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ramos-Miguel et al. (2019) pubmed:30610939|imex:IM-28601 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26578093|imex:IM-28601-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005260865.1|refseq:XP_016883510.1|refseq:NP_003072.2|refseq:NP_570824.1|ensembl:ENSG00000132639(gene)|ensembl:ENST00000254976(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030426"(growth cone)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:P60880|rcsb pdb:1KIL|rcsb pdb:1XTG|rcsb pdb:2N1T|rcsb pdb:3DDA|rcsb pdb:3DDB|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|rcsb pdb:3ZUR|rcsb pdb:5W7I|rcsb pdb:5W7J|rcsb pdb:6JLH|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-422356|reactome:R-HSA-449836|reactome:R-HSA-5250968|reactome:R-HSA-5250971|reactome:R-HSA-5250992|reactome:R-HSA-6798695|reactome:R-HSA-888590|reactome:R-HSA-9662360|refseq:XP_016883511.1|refseq:NP_001309831.1|refseq:NP_001309832.1|refseq:NP_001309833.1|refseq:NP_001309834.1|refseq:NP_001309835.1|refseq:NP_001309836.1|refseq:NP_001309837.1|refseq:NP_001309838.1|refseq:NP_001309839.1|dip:DIP-34554N refseq:NP_004152.1|refseq:NP_056358.1|ensembl:ENSG00000138069(gene)|ensembl:ENST00000409784(transcript)|ensembl:ENST00000649427(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007030"(Golgi organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016477"(cell migration)|go:"GO:0019068"(virion assembly)|go:"GO:0030252"(growth hormone secretion)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0032402"(melanosome transport)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042470"(melanosome)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045296"(cadherin binding)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|go:"GO:1903020"(positive regulation of glycoprotein metabolic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P62820|rcsb pdb:2FOL|rcsb pdb:2WWX|rcsb pdb:3L0I|rcsb pdb:3SFV|rcsb pdb:3TKL|rcsb pdb:4FMB|rcsb pdb:4FMC|rcsb pdb:4FMD|rcsb pdb:4FME|rcsb pdb:4IRU|rcsb pdb:4JVS|reactome:R-HSA-162658|reactome:R-HSA-204005|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-8873719|reactome:R-HSA-8876198|dip:DIP-1063N - - - figure legend:ST2 ST3|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-brain-caudate_nucleus)|taxid:9606(Human brain, caudate nuclear region) - 2020/12/30 2021/01/05 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs9606 rogid:Pa9NYKiCNXtxRwthh1r/pGbZyf09606 rigid:mveF/eKKR/8+XTujVjV5bTZxTE8 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P60880 uniprotkb:P04406 intact:EBI-524785|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|uniprotkb:B2RAU4|uniprotkb:Q53EM2|uniprotkb:Q5U0B5|uniprotkb:D3DW16|uniprotkb:D3DW17|ensembl:ENSP00000254976 intact:EBI-354056|uniprotkb:P00354|uniprotkb:Q53X65|uniprotkb:E7EUT4|ensembl:ENSP00000229239|ensembl:ENSP00000380068|ensembl:ENSP00000380070 psi-mi:snp25_human(display_long)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym)|uniprotkb:SNAP25(gene name)|psi-mi:SNAP25(display_short)|uniprotkb:SNAP(gene name synonym) psi-mi:g3p_human(display_long)|uniprotkb:GAPDH(gene name)|psi-mi:GAPDH(display_short)|uniprotkb:OK/SW-cl.12(orf name)|uniprotkb:CDABP0047(orf name)|uniprotkb:GAPD(gene name synonym)|uniprotkb:Peptidyl-cysteine S-nitrosylase GAPDH(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ramos-Miguel et al. (2019) pubmed:30610939|imex:IM-28601 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26578093|imex:IM-28601-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005260865.1|refseq:XP_016883510.1|refseq:NP_003072.2|refseq:NP_570824.1|ensembl:ENSG00000132639(gene)|ensembl:ENST00000254976(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030426"(growth cone)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:P60880|rcsb pdb:1KIL|rcsb pdb:1XTG|rcsb pdb:2N1T|rcsb pdb:3DDA|rcsb pdb:3DDB|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|rcsb pdb:3ZUR|rcsb pdb:5W7I|rcsb pdb:5W7J|rcsb pdb:6JLH|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-422356|reactome:R-HSA-449836|reactome:R-HSA-5250968|reactome:R-HSA-5250971|reactome:R-HSA-5250992|reactome:R-HSA-6798695|reactome:R-HSA-888590|reactome:R-HSA-9662360|refseq:XP_016883511.1|refseq:NP_001309831.1|refseq:NP_001309832.1|refseq:NP_001309833.1|refseq:NP_001309834.1|refseq:NP_001309835.1|refseq:NP_001309836.1|refseq:NP_001309837.1|refseq:NP_001309838.1|refseq:NP_001309839.1|dip:DIP-34554N refseq:NP_002037.2|refseq:NP_001243728.1|refseq:NP_001276674.1|refseq:NP_001276675.1|dip:DIP-32521N|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0035605"(peptidyl-cysteine S-nitrosylase activity)|go:"GO:0035606"(peptidyl-cysteine S-trans-nitrosylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050661"(NADP binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051287"(NAD binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097452"(GAIT complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006424(Glyceraldehyde-3-phosphate dehydrogenase, type I)|interpro:IPR020828|interpro:IPR020829|interpro:IPR020830|interpro:IPR020831|interpro:IPR036291|mint:P04406|rcsb pdb:1U8F|rcsb pdb:1ZNQ|rcsb pdb:2FEH|rcsb pdb:3GPD|rcsb pdb:4WNC|rcsb pdb:4WNI|rcsb pdb:6ADE|rcsb pdb:6M61|rcsb pdb:6YND|rcsb pdb:6YNE|rcsb pdb:6YNF|rcsb pdb:6YNH|reactome:R-HSA-70171|reactome:R-HSA-70263|rcsb pdb:6IQ6|ensembl:ENSG00000111640(gene)|ensembl:ENST00000229239(transcript)|ensembl:ENST00000396859(transcript)|ensembl:ENST00000396861(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004365"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0008017"(microtubule binding)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0031640"(killing of cells of another organism) - - - figure legend:ST2 ST3|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-brain-caudate_nucleus)|taxid:9606(Human brain, caudate nuclear region) - 2020/12/30 2021/01/05 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs9606 rogid:9YENN/dfKl/d0tJtfFyQp2o8eAc9606 rigid:mveF/eKKR/8+XTujVjV5bTZxTE8 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P60880 uniprotkb:P60601 intact:EBI-524785|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|uniprotkb:B2RAU4|uniprotkb:Q53EM2|uniprotkb:Q5U0B5|uniprotkb:D3DW16|uniprotkb:D3DW17|ensembl:ENSP00000254976 intact:EBI-26578057|ensemblbacteria:CAE25755 psi-mi:snp25_human(display_long)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym)|uniprotkb:SNAP25(gene name)|psi-mi:SNAP25(display_short)|uniprotkb:SNAP(gene name synonym) psi-mi:his5_rhopa(display_long)|uniprotkb:IGP synthase glutaminase subunit(gene name synonym)|uniprotkb:IGP synthase subunit HisH(gene name synonym)|uniprotkb:ImGP synthase subunit HisH(gene name synonym)|uniprotkb:RPA0311(locus name)|uniprotkb:hisH(gene name)|psi-mi:hisH(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ramos-Miguel et al. (2019) pubmed:30610939|imex:IM-28601 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:258594(rhopa)|taxid:258594("Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)") psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26578093|imex:IM-28601-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005260865.1|refseq:XP_016883510.1|refseq:NP_003072.2|refseq:NP_570824.1|ensembl:ENSG00000132639(gene)|ensembl:ENST00000254976(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030426"(growth cone)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:P60880|rcsb pdb:1KIL|rcsb pdb:1XTG|rcsb pdb:2N1T|rcsb pdb:3DDA|rcsb pdb:3DDB|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|rcsb pdb:3ZUR|rcsb pdb:5W7I|rcsb pdb:5W7J|rcsb pdb:6JLH|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-422356|reactome:R-HSA-449836|reactome:R-HSA-5250968|reactome:R-HSA-5250971|reactome:R-HSA-5250992|reactome:R-HSA-6798695|reactome:R-HSA-888590|reactome:R-HSA-9662360|refseq:XP_016883511.1|refseq:NP_001309831.1|refseq:NP_001309832.1|refseq:NP_001309833.1|refseq:NP_001309834.1|refseq:NP_001309835.1|refseq:NP_001309836.1|refseq:NP_001309837.1|refseq:NP_001309838.1|refseq:NP_001309839.1|dip:DIP-34554N ensemblbacteria:CAE25755(transcript)|ensemblbacteria:RPA0311(gene)|go:"GO:0000105"(histidine biosynthetic process)|go:"GO:0000107"(imidazoleglycerol-phosphate synthase activity)|go:"GO:0004359"(glutaminase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0016829"(lyase activity)|go:"GO:0006541"(glutamine metabolic process)|mint:P60601|refseq:WP_011155879.1|interpro:IPR029062|interpro:IPR017926|interpro:IPR010139(Imidazole glycerol phosphate synthase, subunit H) - - - figure legend:ST2 ST3|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-brain-caudate_nucleus)|taxid:9606(Human brain, caudate nuclear region) - 2020/12/30 2021/01/05 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs9606 rogid:Lw3hkatIndmrLrWNy2d6W8ngU6M258594 rigid:mveF/eKKR/8+XTujVjV5bTZxTE8 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P60880 uniprotkb:P84077 intact:EBI-524785|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|uniprotkb:B2RAU4|uniprotkb:Q53EM2|uniprotkb:Q5U0B5|uniprotkb:D3DW16|uniprotkb:D3DW17|ensembl:ENSP00000254976 intact:EBI-447171|uniprotkb:P10947|uniprotkb:P32889|ensembl:ENSP00000272102|ensembl:ENSP00000440005|ensembl:ENSP00000442980 psi-mi:snp25_human(display_long)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym)|uniprotkb:SNAP25(gene name)|psi-mi:SNAP25(display_short)|uniprotkb:SNAP(gene name synonym) psi-mi:arf1_human(display_long)|uniprotkb:ARF1(gene name)|psi-mi:ARF1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ramos-Miguel et al. (2019) pubmed:30610939|imex:IM-28601 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26578093|imex:IM-28601-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005260865.1|refseq:XP_016883510.1|refseq:NP_003072.2|refseq:NP_570824.1|ensembl:ENSG00000132639(gene)|ensembl:ENST00000254976(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030426"(growth cone)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:P60880|rcsb pdb:1KIL|rcsb pdb:1XTG|rcsb pdb:2N1T|rcsb pdb:3DDA|rcsb pdb:3DDB|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|rcsb pdb:3ZUR|rcsb pdb:5W7I|rcsb pdb:5W7J|rcsb pdb:6JLH|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-422356|reactome:R-HSA-449836|reactome:R-HSA-5250968|reactome:R-HSA-5250971|reactome:R-HSA-5250992|reactome:R-HSA-6798695|reactome:R-HSA-888590|reactome:R-HSA-9662360|refseq:XP_016883511.1|refseq:NP_001309831.1|refseq:NP_001309832.1|refseq:NP_001309833.1|refseq:NP_001309834.1|refseq:NP_001309835.1|refseq:NP_001309836.1|refseq:NP_001309837.1|refseq:NP_001309838.1|refseq:NP_001309839.1|dip:DIP-34554N refseq:NP_001019397.1|refseq:NP_001019398.1|refseq:NP_001019399.1|refseq:NP_001649.1|dip:DIP-31597N|ensembl:ENSG00000143761(gene)|ensembl:ENST00000272102(transcript)|ensembl:ENST00000540651(transcript)|ensembl:ENST00000541182(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005770"(late endosome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007015"(actin filament organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019003"(GDP binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0043005"(neuron projection)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0055108"(Golgi to transport vesicle transport)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070142"(synaptic vesicle budding)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097212"(lysosomal membrane organization)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902307"(positive regulation of sodium ion transmembrane transport)|go:"GO:1902824"(positive regulation of late endosome to lysosome transport)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:1903725"(regulation of phospholipid metabolic process)|go:"GO:1990386"(mitotic cleavage furrow ingression)|go:"GO:1990583"(phospholipase D activator activity)|interpro:IPR005225(Small GTP-binding protein)|go:"GO:1902953"(positive regulation of ER to Golgi vesicle-mediated transport)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|mint:P84077|rcsb pdb:1HUR|rcsb pdb:1RE0|rcsb pdb:1U81|rcsb pdb:3O47|rcsb pdb:4HMY|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|rcsb pdb:6FAE|rcsb pdb:7MGE|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-167590|reactome:R-HSA-199992|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811438|reactome:R-HSA-8950505 - - - figure legend:ST2 ST3|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-brain-caudate_nucleus)|taxid:9606(Human brain, caudate nuclear region) - 2020/12/30 2021/01/05 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs9606 rogid:zray9asm6VonxpuJpv0dRBspPt89606 rigid:mveF/eKKR/8+XTujVjV5bTZxTE8 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P60880 uniprotkb:P11142 intact:EBI-524785|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|uniprotkb:B2RAU4|uniprotkb:Q53EM2|uniprotkb:Q5U0B5|uniprotkb:D3DW16|uniprotkb:D3DW17|ensembl:ENSP00000254976 intact:EBI-351896|uniprotkb:Q9H3R6|ensembl:ENSP00000227378|ensembl:ENSP00000432083|ensembl:ENSP00000437125 psi-mi:snp25_human(display_long)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym)|uniprotkb:SNAP25(gene name)|psi-mi:SNAP25(display_short)|uniprotkb:SNAP(gene name synonym) psi-mi:hsp7c_human(display_long)|uniprotkb:HSPA8(gene name)|psi-mi:HSPA8(display_short)|uniprotkb:HSC70(gene name synonym)|uniprotkb:HSP73(gene name synonym)|uniprotkb:HSPA10(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 8(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ramos-Miguel et al. (2019) pubmed:30610939|imex:IM-28601 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26578093|imex:IM-28601-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005260865.1|refseq:XP_016883510.1|refseq:NP_003072.2|refseq:NP_570824.1|ensembl:ENSG00000132639(gene)|ensembl:ENST00000254976(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030426"(growth cone)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:P60880|rcsb pdb:1KIL|rcsb pdb:1XTG|rcsb pdb:2N1T|rcsb pdb:3DDA|rcsb pdb:3DDB|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|rcsb pdb:3ZUR|rcsb pdb:5W7I|rcsb pdb:5W7J|rcsb pdb:6JLH|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-422356|reactome:R-HSA-449836|reactome:R-HSA-5250968|reactome:R-HSA-5250971|reactome:R-HSA-5250992|reactome:R-HSA-6798695|reactome:R-HSA-888590|reactome:R-HSA-9662360|refseq:XP_016883511.1|refseq:NP_001309831.1|refseq:NP_001309832.1|refseq:NP_001309833.1|refseq:NP_001309834.1|refseq:NP_001309835.1|refseq:NP_001309836.1|refseq:NP_001309837.1|refseq:NP_001309838.1|refseq:NP_001309839.1|dip:DIP-34554N refseq:NP_006588.1|refseq:NP_694881.1|refseq:XP_011541100.1|ensembl:ENSG00000109971(gene)|ensembl:ENST00000227378(transcript)|ensembl:ENST00000532636(transcript)|ensembl:ENST00000534624(transcript)|go:"GO:0000974"(Prp19 complex)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0043195"(terminal bouton)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061024"(membrane organization)|go:"GO:0061202"(clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0098575"(lumenal side of lysosomal membrane)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0101031"(chaperone complex)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902904"(negative regulation of supramolecular fiber organization)|go:"GO:1904589"(regulation of protein import)|go:"GO:1904764"(chaperone-mediated autophagy translocation complex disassembly)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1990832"(slow axonal transport)|go:"GO:1990833"(clathrin-uncoating ATPase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P11142|rcsb pdb:3AGY|rcsb pdb:3AGZ|rcsb pdb:3ESK|rcsb pdb:3FZF|rcsb pdb:3FZH|rcsb pdb:3FZK|rcsb pdb:3FZL|rcsb pdb:3FZM|rcsb pdb:3LDQ|rcsb pdb:3M3Z|rcsb pdb:4H5N|rcsb pdb:4H5R|rcsb pdb:4H5T|rcsb pdb:4H5V|rcsb pdb:4H5W|rcsb pdb:4HWI|rcsb pdb:4KBQ|rcsb pdb:5AQF|rcsb pdb:5AQG|rcsb pdb:5AQH|rcsb pdb:5AQI|rcsb pdb:5AQJ|rcsb pdb:5AQK|rcsb pdb:5AQL|rcsb pdb:5AQM|rcsb pdb:5AQN|rcsb pdb:5AQO|rcsb pdb:5AQP|rcsb pdb:5AQQ|rcsb pdb:5AQR|rcsb pdb:5AQS|rcsb pdb:5AQT|rcsb pdb:5AQU|rcsb pdb:5AQV|rcsb pdb:6B1I|rcsb pdb:6B1M|rcsb pdb:6B1N|rcsb pdb:6ZYJ|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-447041|reactome:R-HSA-450408|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-72163|reactome:R-HSA-8856828|reactome:R-HSA-8876725|reactome:R-HSA-888590|reactome:R-HSA-9613354|reactome:R-HSA-9613829|reactome:R-HSA-9615710|dip:DIP-32874N - - - figure legend:ST2 ST3|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-brain-caudate_nucleus)|taxid:9606(Human brain, caudate nuclear region) - 2020/12/30 2021/01/05 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs9606 rogid:0I+wYut3naJRzzgmMSax/1mZZwA9606 rigid:mveF/eKKR/8+XTujVjV5bTZxTE8 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P60880 uniprotkb:P25705 intact:EBI-524785|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|uniprotkb:B2RAU4|uniprotkb:Q53EM2|uniprotkb:Q5U0B5|uniprotkb:D3DW16|uniprotkb:D3DW17|ensembl:ENSP00000254976 intact:EBI-351437|uniprotkb:Q53XX6|uniprotkb:Q8IXV2|uniprotkb:Q96FB4|uniprotkb:Q96HW2|uniprotkb:Q96IR6|uniprotkb:Q9BTV8|intact:EBI-11032691|uniprotkb:A8K092|uniprotkb:B4DY56|uniprotkb:K7ENP3|ensembl:ENSP00000282050|ensembl:ENSP00000381736 psi-mi:snp25_human(display_long)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym)|uniprotkb:SNAP25(gene name)|psi-mi:SNAP25(display_short)|uniprotkb:SNAP(gene name synonym) psi-mi:atpa_human(display_long)|uniprotkb:ATP5F1A(gene name)|psi-mi:ATP5F1A(display_short)|uniprotkb:ATP synthase F1 subunit alpha(gene name synonym)|uniprotkb:ATP5A(gene name synonym)|uniprotkb:ATP5A1(gene name synonym)|uniprotkb:ATP5AL2(gene name synonym)|uniprotkb:ATPM(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ramos-Miguel et al. (2019) pubmed:30610939|imex:IM-28601 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26578093|imex:IM-28601-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005260865.1|refseq:XP_016883510.1|refseq:NP_003072.2|refseq:NP_570824.1|ensembl:ENSG00000132639(gene)|ensembl:ENST00000254976(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030426"(growth cone)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:P60880|rcsb pdb:1KIL|rcsb pdb:1XTG|rcsb pdb:2N1T|rcsb pdb:3DDA|rcsb pdb:3DDB|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|rcsb pdb:3ZUR|rcsb pdb:5W7I|rcsb pdb:5W7J|rcsb pdb:6JLH|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-422356|reactome:R-HSA-449836|reactome:R-HSA-5250968|reactome:R-HSA-5250971|reactome:R-HSA-5250992|reactome:R-HSA-6798695|reactome:R-HSA-888590|reactome:R-HSA-9662360|refseq:XP_016883511.1|refseq:NP_001309831.1|refseq:NP_001309832.1|refseq:NP_001309833.1|refseq:NP_001309834.1|refseq:NP_001309835.1|refseq:NP_001309836.1|refseq:NP_001309837.1|refseq:NP_001309838.1|refseq:NP_001309839.1|dip:DIP-34554N refseq:NP_001244263.1|refseq:NP_001001937.1|refseq:NP_004037.1|refseq:NP_001001935.1|refseq:NP_001244264.1|dip:DIP-32871N|ensembl:ENSG00000152234(gene)|ensembl:ENST00000282050(transcript)|ensembl:ENST00000398752(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005754"(mitochondrial proton-transporting ATP synthase, catalytic core)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0043531"(ADP binding)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045259"(proton-transporting ATP synthase complex)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR000793(ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005294(ATPase, F1 complex, alpha subunit)|interpro:IPR020003|interpro:IPR023366|interpro:IPR027417|interpro:IPR033732|interpro:IPR036121|interpro:IPR038376|mint:P25705|reactome:R-HSA-1268020|reactome:R-HSA-163210|reactome:R-HSA-8949613 - - - figure legend:ST2 ST3|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-brain-caudate_nucleus)|taxid:9606(Human brain, caudate nuclear region) - 2020/12/30 2021/01/05 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs9606 rogid:Sy/Ii5ea+ilCKGBnIEMn133Vogc9606 rigid:mveF/eKKR/8+XTujVjV5bTZxTE8 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P60880 uniprotkb:P61421 intact:EBI-524785|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|uniprotkb:B2RAU4|uniprotkb:Q53EM2|uniprotkb:Q5U0B5|uniprotkb:D3DW16|uniprotkb:D3DW17|ensembl:ENSP00000254976 intact:EBI-954063|ensembl:ENSP00000290949|uniprotkb:P12953|uniprotkb:Q02547 psi-mi:snp25_human(display_long)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym)|uniprotkb:SNAP25(gene name)|psi-mi:SNAP25(display_short)|uniprotkb:SNAP(gene name synonym) psi-mi:va0d1_human(display_long)|uniprotkb:Vacuolar proton pump subunit d 1(gene name synonym)|uniprotkb:V-ATPase AC39 subunit(gene name synonym)|uniprotkb:V-ATPase 40 kDa accessory protein(gene name synonym)|uniprotkb:32 kDa accessory protein(gene name synonym)|uniprotkb:ATP6V0D1(gene name)|psi-mi:ATP6V0D1(display_short)|uniprotkb:ATP6D(gene name synonym)|uniprotkb:VPATPD(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ramos-Miguel et al. (2019) pubmed:30610939|imex:IM-28601 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26578093|imex:IM-28601-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005260865.1|refseq:XP_016883510.1|refseq:NP_003072.2|refseq:NP_570824.1|ensembl:ENSG00000132639(gene)|ensembl:ENST00000254976(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030426"(growth cone)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:P60880|rcsb pdb:1KIL|rcsb pdb:1XTG|rcsb pdb:2N1T|rcsb pdb:3DDA|rcsb pdb:3DDB|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|rcsb pdb:3ZUR|rcsb pdb:5W7I|rcsb pdb:5W7J|rcsb pdb:6JLH|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-422356|reactome:R-HSA-449836|reactome:R-HSA-5250968|reactome:R-HSA-5250971|reactome:R-HSA-5250992|reactome:R-HSA-6798695|reactome:R-HSA-888590|reactome:R-HSA-9662360|refseq:XP_016883511.1|refseq:NP_001309831.1|refseq:NP_001309832.1|refseq:NP_001309833.1|refseq:NP_001309834.1|refseq:NP_001309835.1|refseq:NP_001309836.1|refseq:NP_001309837.1|refseq:NP_001309838.1|refseq:NP_001309839.1|dip:DIP-34554N ensembl:ENSG00000159720(gene)|ensembl:ENST00000290949(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007034"(vacuolar transport)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0007420"(brain development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0033179"(proton-transporting V-type ATPase, V0 domain)|go:"GO:0033181"(plasma membrane proton-transporting V-type ATPase complex)|go:"GO:0036295"(cellular response to increased oxygen levels)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR002843(ATPase, V0/A0 complex, subunit C/D)|interpro:IPR016727(ATPase, V0 complex, subunit D)|interpro:IPR035067|interpro:IPR036079|interpro:IPR044911|mint:P61421|rcsb pdb:6WLW|rcsb pdb:6WM2|rcsb pdb:6WM3|rcsb pdb:6WM4|reactome:R-HSA-1222556|reactome:R-HSA-381038|reactome:R-HSA-77387|reactome:R-HSA-917977|reactome:R-HSA-9639288|reactome:R-HSA-983712|go:"GO:0016324"(apical plasma membrane)|refseq:NP_004682.2|dip:DIP-47435N - - - figure legend:ST2 ST3|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-brain-caudate_nucleus)|taxid:9606(Human brain, caudate nuclear region) - 2020/12/30 2021/01/05 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs9606 rogid:3a/yIxEF9LMwAZUR3npGQrw8xNo9606 rigid:mveF/eKKR/8+XTujVjV5bTZxTE8 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P60880 uniprotkb:Q15904 intact:EBI-524785|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|uniprotkb:B2RAU4|uniprotkb:Q53EM2|uniprotkb:Q5U0B5|uniprotkb:D3DW16|uniprotkb:D3DW17|ensembl:ENSP00000254976 intact:EBI-714667|uniprotkb:Q8NBT4|uniprotkb:Q9H0C7|uniprotkb:A6ZKI4|ensembl:ENSP00000358777 psi-mi:snp25_human(display_long)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym)|uniprotkb:SNAP25(gene name)|psi-mi:SNAP25(display_short)|uniprotkb:SNAP(gene name synonym) psi-mi:vas1_human(display_long)|uniprotkb:V-ATPase S1 accessory protein(gene name synonym)|uniprotkb:V-ATPase Ac45 subunit(gene name synonym)|uniprotkb:Protein XAP-3(gene name synonym)|uniprotkb:ATP6AP1(gene name)|psi-mi:ATP6AP1(display_short)|uniprotkb:ATP6IP1(gene name synonym)|uniprotkb:ATP6S1(gene name synonym)|uniprotkb:VATPS1(gene name synonym)|uniprotkb:XAP3(gene name synonym)|uniprotkb:Vacuolar proton pump subunit S1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ramos-Miguel et al. (2019) pubmed:30610939|imex:IM-28601 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26578093|imex:IM-28601-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005260865.1|refseq:XP_016883510.1|refseq:NP_003072.2|refseq:NP_570824.1|ensembl:ENSG00000132639(gene)|ensembl:ENST00000254976(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030426"(growth cone)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:P60880|rcsb pdb:1KIL|rcsb pdb:1XTG|rcsb pdb:2N1T|rcsb pdb:3DDA|rcsb pdb:3DDB|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|rcsb pdb:3ZUR|rcsb pdb:5W7I|rcsb pdb:5W7J|rcsb pdb:6JLH|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-422356|reactome:R-HSA-449836|reactome:R-HSA-5250968|reactome:R-HSA-5250971|reactome:R-HSA-5250992|reactome:R-HSA-6798695|reactome:R-HSA-888590|reactome:R-HSA-9662360|refseq:XP_016883511.1|refseq:NP_001309831.1|refseq:NP_001309832.1|refseq:NP_001309833.1|refseq:NP_001309834.1|refseq:NP_001309835.1|refseq:NP_001309836.1|refseq:NP_001309837.1|refseq:NP_001309838.1|refseq:NP_001309839.1|dip:DIP-34554N refseq:NP_001174.2|ensembl:ENSG00000071553(gene)|ensembl:ENST00000369762(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016469"(proton-transporting two-sector ATPase complex)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0031267"(small GTPase binding)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0033180"(proton-transporting V-type ATPase, V1 domain)|go:"GO:0033181"(plasma membrane proton-transporting V-type ATPase complex)|go:"GO:0036295"(cellular response to increased oxygen levels)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045851"(pH reduction)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0051656"(establishment of organelle localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1902600"(proton transmembrane transport)|go:"GO:2001206"(positive regulation of osteoclast development)|interpro:IPR008388(ATPase, V1 complex, subunit S1)|mint:Q15904|rcsb pdb:6WLW|rcsb pdb:6WM2|rcsb pdb:6WM3|rcsb pdb:6WM4|reactome:R-HSA-77387|reactome:R-HSA-8980692|reactome:R-HSA-917977|reactome:R-HSA-983712|refseq:XP_011529481.1 - - - figure legend:ST2 ST3|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-brain-caudate_nucleus)|taxid:9606(Human brain, caudate nuclear region) - 2020/12/30 2021/01/05 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs9606 rogid:c5zqmRYvzBfRy1BdJteDGueEjY49606 rigid:mveF/eKKR/8+XTujVjV5bTZxTE8 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P60880 uniprotkb:Q9H313 intact:EBI-524785|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|uniprotkb:B2RAU4|uniprotkb:Q53EM2|uniprotkb:Q5U0B5|uniprotkb:D3DW16|uniprotkb:D3DW17|ensembl:ENSP00000254976 intact:EBI-20793786|uniprotkb:B0VJY3|uniprotkb:B0VJY4|uniprotkb:B0VJY5|uniprotkb:B2VAL9|uniprotkb:Q5U682|uniprotkb:Q68A17|uniprotkb:Q6L750|uniprotkb:Q6ZTE5|uniprotkb:Q8WUU2|ensembl:ENSP00000365713|ensembl:ENSP00000480769|ensembl:ENSP00000481138|ensembl:ENSP00000484774 psi-mi:snp25_human(display_long)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym)|uniprotkb:SNAP25(gene name)|psi-mi:SNAP25(display_short)|uniprotkb:SNAP(gene name synonym) psi-mi:ttyh1_human(display_long)|uniprotkb:TTYH1(gene name)|psi-mi:TTYH1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ramos-Miguel et al. (2019) pubmed:30610939|imex:IM-28601 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26578093|imex:IM-28601-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005260865.1|refseq:XP_016883510.1|refseq:NP_003072.2|refseq:NP_570824.1|ensembl:ENSG00000132639(gene)|ensembl:ENST00000254976(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030426"(growth cone)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:P60880|rcsb pdb:1KIL|rcsb pdb:1XTG|rcsb pdb:2N1T|rcsb pdb:3DDA|rcsb pdb:3DDB|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|rcsb pdb:3ZUR|rcsb pdb:5W7I|rcsb pdb:5W7J|rcsb pdb:6JLH|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-422356|reactome:R-HSA-449836|reactome:R-HSA-5250968|reactome:R-HSA-5250971|reactome:R-HSA-5250992|reactome:R-HSA-6798695|reactome:R-HSA-888590|reactome:R-HSA-9662360|refseq:XP_016883511.1|refseq:NP_001309831.1|refseq:NP_001309832.1|refseq:NP_001309833.1|refseq:NP_001309834.1|refseq:NP_001309835.1|refseq:NP_001309836.1|refseq:NP_001309837.1|refseq:NP_001309838.1|refseq:NP_001309839.1|dip:DIP-34554N refseq:NP_001005367.1|refseq:NP_001188390.1|refseq:NP_065710.1|go:"GO:0007155"(cell adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034707"(chloride channel complex)|go:"GO:0072320"(volume-sensitive chloride channel activity)|interpro:IPR006990(Tweety)|mint:Q9H313|reactome:R-HSA-2672351|ensembl:ENSG00000167614(gene)|ensembl:ENSG00000275650(gene)|ensembl:ENSG00000276537(gene)|ensembl:ENSG00000276887(gene)|ensembl:ENST00000376530(transcript)|ensembl:ENST00000611711(transcript)|ensembl:ENST00000619450(transcript)|ensembl:ENST00000620298(transcript)|go:"GO:0005229"(intracellular calcium activated chloride channel activity)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005381"(iron ion transmembrane transporter activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006821"(chloride transport)|go:"GO:0006826"(iron ion transport) - - - figure legend:ST2 ST3|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-brain-caudate_nucleus)|taxid:9606(Human brain, caudate nuclear region) - 2020/12/30 2021/01/05 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs9606 rogid:iaivv85TtJGcZfrVUIFCs8YThuU9606 rigid:mveF/eKKR/8+XTujVjV5bTZxTE8 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P60880 uniprotkb:P36542 intact:EBI-524785|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|uniprotkb:B2RAU4|uniprotkb:Q53EM2|uniprotkb:Q5U0B5|uniprotkb:D3DW16|uniprotkb:D3DW17|ensembl:ENSP00000254976 intact:EBI-711768|uniprotkb:Q5VYP3|uniprotkb:Q96AS8|uniprotkb:A8KA31|intact:EBI-3962282|uniprotkb:Q6I9V2|ensembl:ENSP00000349142 psi-mi:snp25_human(display_long)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym)|uniprotkb:SNAP25(gene name)|psi-mi:SNAP25(display_short)|uniprotkb:SNAP(gene name synonym) psi-mi:atpg_human(display_long)|uniprotkb:ATP5F1C(gene name)|psi-mi:ATP5F1C(display_short)|uniprotkb:ATP synthase F1 subunit gamma(gene name synonym)|uniprotkb:ATP5C(gene name synonym)|uniprotkb:ATP5C1(gene name synonym)|uniprotkb:ATP5CL1(gene name synonym)|uniprotkb:F-ATPase gamma subunit(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ramos-Miguel et al. (2019) pubmed:30610939|imex:IM-28601 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26578093|imex:IM-28601-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005260865.1|refseq:XP_016883510.1|refseq:NP_003072.2|refseq:NP_570824.1|ensembl:ENSG00000132639(gene)|ensembl:ENST00000254976(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030426"(growth cone)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:P60880|rcsb pdb:1KIL|rcsb pdb:1XTG|rcsb pdb:2N1T|rcsb pdb:3DDA|rcsb pdb:3DDB|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|rcsb pdb:3ZUR|rcsb pdb:5W7I|rcsb pdb:5W7J|rcsb pdb:6JLH|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-422356|reactome:R-HSA-449836|reactome:R-HSA-5250968|reactome:R-HSA-5250971|reactome:R-HSA-5250992|reactome:R-HSA-6798695|reactome:R-HSA-888590|reactome:R-HSA-9662360|refseq:XP_016883511.1|refseq:NP_001309831.1|refseq:NP_001309832.1|refseq:NP_001309833.1|refseq:NP_001309834.1|refseq:NP_001309835.1|refseq:NP_001309836.1|refseq:NP_001309837.1|refseq:NP_001309838.1|refseq:NP_001309839.1|dip:DIP-34554N refseq:NP_001001973.1|refseq:NP_005165.1|ensembl:ENSG00000165629(gene)|ensembl:ENST00000356708(transcript)|go:"GO:0000275"("mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)")|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|interpro:IPR000131(ATPase, F1 complex, gamma subunit)|interpro:IPR023632|interpro:IPR035968|mint:P36542|reactome:R-HSA-163210|reactome:R-HSA-8949613 - - - figure legend:ST2 ST3|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-brain-caudate_nucleus)|taxid:9606(Human brain, caudate nuclear region) - 2020/12/30 2021/01/05 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs9606 rogid:k3Nfa1hSoREyiKzFbmaZqxLhiLY9606 rigid:mveF/eKKR/8+XTujVjV5bTZxTE8 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P60880 uniprotkb:P20336 intact:EBI-524785|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|uniprotkb:B2RAU4|uniprotkb:Q53EM2|uniprotkb:Q5U0B5|uniprotkb:D3DW16|uniprotkb:D3DW17|ensembl:ENSP00000254976 intact:EBI-1045943|uniprotkb:Q9NYE1|uniprotkb:A8K0J4|ensembl:ENSP00000222256 psi-mi:snp25_human(display_long)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym)|uniprotkb:SNAP25(gene name)|psi-mi:SNAP25(display_short)|uniprotkb:SNAP(gene name synonym) psi-mi:rab3a_human(display_long)|uniprotkb:RAB3A(gene name)|psi-mi:RAB3A(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ramos-Miguel et al. (2019) pubmed:30610939|imex:IM-28601 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26578093|imex:IM-28601-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005260865.1|refseq:XP_016883510.1|refseq:NP_003072.2|refseq:NP_570824.1|ensembl:ENSG00000132639(gene)|ensembl:ENST00000254976(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030426"(growth cone)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:P60880|rcsb pdb:1KIL|rcsb pdb:1XTG|rcsb pdb:2N1T|rcsb pdb:3DDA|rcsb pdb:3DDB|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|rcsb pdb:3ZUR|rcsb pdb:5W7I|rcsb pdb:5W7J|rcsb pdb:6JLH|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-422356|reactome:R-HSA-449836|reactome:R-HSA-5250968|reactome:R-HSA-5250971|reactome:R-HSA-5250992|reactome:R-HSA-6798695|reactome:R-HSA-888590|reactome:R-HSA-9662360|refseq:XP_016883511.1|refseq:NP_001309831.1|refseq:NP_001309832.1|refseq:NP_001309833.1|refseq:NP_001309834.1|refseq:NP_001309835.1|refseq:NP_001309836.1|refseq:NP_001309837.1|refseq:NP_001309838.1|refseq:NP_001309839.1|dip:DIP-34554N refseq:NP_002857.1|ensembl:ENSG00000105649(gene)|ensembl:ENST00000222256(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0003016"(respiratory system process)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009306"(protein secretion)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010807"(regulation of synaptic vesicle priming)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0030324"(lung development)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0030424"(axon)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0031630"(regulation of synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0032418"(lysosome localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0043195"(terminal bouton)|go:"GO:0045054"(constitutive secretory pathway)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048790"(maintenance of presynaptic active zone structure)|go:"GO:0050975"(sensory perception of touch)|go:"GO:0051021"(GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060201"(clathrin-sculpted acetylcholine transport vesicle membrane)|go:"GO:0060203"(clathrin-sculpted glutamate transport vesicle membrane)|go:"GO:0060478"(acrosomal vesicle exocytosis)|go:"GO:0061202"(clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane)|go:"GO:0061670"(evoked neurotransmitter secretion)|go:"GO:0070083"(clathrin-sculpted monoamine transport vesicle membrane)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:1903307"(positive regulation of regulated secretory pathway)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1905684"(regulation of plasma membrane repair)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR001806(Ras GTPase)|interpro:IPR027417|interpro:IPR037872|mint:P20336|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|interpro:IPR005225(Small GTP-binding protein)|reactome:R-HSA-264642|reactome:R-HSA-6798695|reactome:R-HSA-8873719|reactome:R-HSA-8876198|reactome:R-HSA-888590|reactome:R-HSA-9662360|refseq:XP_011526466.1 - - - figure legend:ST2 ST3|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-brain-caudate_nucleus)|taxid:9606(Human brain, caudate nuclear region) - 2020/12/30 2021/01/05 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs9606 rogid:mByWzDHvitYqJ1l4Fjjuq55Y9TA9606 rigid:mveF/eKKR/8+XTujVjV5bTZxTE8 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P60880 uniprotkb:P55072 intact:EBI-524785|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|uniprotkb:B2RAU4|uniprotkb:Q53EM2|uniprotkb:Q5U0B5|uniprotkb:D3DW16|uniprotkb:D3DW17|ensembl:ENSP00000254976 intact:EBI-355164|uniprotkb:Q969G7|uniprotkb:Q9UCD5|uniprotkb:B2R5T8|uniprotkb:Q0V924|uniprotkb:Q2TAI5|intact:EBI-1046421|ensembl:ENSP00000351777 psi-mi:snp25_human(display_long)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym)|uniprotkb:SNAP25(gene name)|psi-mi:SNAP25(display_short)|uniprotkb:SNAP(gene name synonym) psi-mi:tera_human(display_long)|uniprotkb:VCP(gene name)|psi-mi:VCP(display_short)|uniprotkb:"15S Mg(2+)-ATPase p97 subunit"(gene name synonym)|uniprotkb:Valosin-containing protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ramos-Miguel et al. (2019) pubmed:30610939|imex:IM-28601 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26578093|imex:IM-28601-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005260865.1|refseq:XP_016883510.1|refseq:NP_003072.2|refseq:NP_570824.1|ensembl:ENSG00000132639(gene)|ensembl:ENST00000254976(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030426"(growth cone)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:P60880|rcsb pdb:1KIL|rcsb pdb:1XTG|rcsb pdb:2N1T|rcsb pdb:3DDA|rcsb pdb:3DDB|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|rcsb pdb:3ZUR|rcsb pdb:5W7I|rcsb pdb:5W7J|rcsb pdb:6JLH|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-422356|reactome:R-HSA-449836|reactome:R-HSA-5250968|reactome:R-HSA-5250971|reactome:R-HSA-5250992|reactome:R-HSA-6798695|reactome:R-HSA-888590|reactome:R-HSA-9662360|refseq:XP_016883511.1|refseq:NP_001309831.1|refseq:NP_001309832.1|refseq:NP_001309833.1|refseq:NP_001309834.1|refseq:NP_001309835.1|refseq:NP_001309836.1|refseq:NP_001309837.1|refseq:NP_001309838.1|refseq:NP_001309839.1|dip:DIP-34554N refseq:NP_009057.1|rcsb pdb:7BPA|rcsb pdb:7BPB|rcsb pdb:7JY5|reactome:R-HSA-110320|reactome:R-HSA-3371511|reactome:R-HSA-382556|reactome:R-HSA-532668|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|reactome:R-HSA-5689877|reactome:R-HSA-5689896|reactome:R-HSA-6798695|reactome:R-HSA-8866654|reactome:R-HSA-8876725|reactome:R-HSA-9013407|reactome:R-HSA-9646399|reactome:R-HSA-9678110|reactome:R-HSA-9694614|rcsb pdb:7BP9|go:"GO:0032510"(endosome to lysosome transport via multivesicular body sorting pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035617"(stress granule disassembly)|go:"GO:0035800"(deubiquitinase activator activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043531"(ADP binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072389"(flavin adenine dinucleotide catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106300"(protein-DNA covalent cross-linking repair)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903006"(positive regulation of protein K63-linked deubiquitination)|go:"GO:1903007"(positive regulation of Lys63-specific deubiquitinase activity)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903843"(cellular response to arsenite ion)|go:"GO:1903862"(positive regulation of oxidative phosphorylation)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1904949"(ATPase complex)|go:"GO:1905634"(regulation of protein localization to chromatin)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990730"(VCP-NSFL1C complex)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|ensembl:ENSG00000165280(gene)|ensembl:ENST00000358901(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006914"(autophagy)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008289"(lipid binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019079"(viral genome replication)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|mint:P55072|rcsb pdb:3EBB|rcsb pdb:3HU1|rcsb pdb:3HU2|rcsb pdb:3HU3|rcsb pdb:3QC8|rcsb pdb:3QQ7|rcsb pdb:3QQ8|rcsb pdb:3QWZ|rcsb pdb:3TIW|rcsb pdb:4KDI|rcsb pdb:4KDL|rcsb pdb:4KLN|rcsb pdb:4KO8|rcsb pdb:4KOD|rcsb pdb:4P0A|rcsb pdb:5B6C|rcsb pdb:5C18|rcsb pdb:5C19|rcsb pdb:5C1A|rcsb pdb:5C1B|rcsb pdb:5DYG|rcsb pdb:5DYI|rcsb pdb:5EPP|rcsb pdb:5FTJ|rcsb pdb:5FTK|rcsb pdb:5FTL|rcsb pdb:5FTM|rcsb pdb:5FTN|rcsb pdb:5GLF|rcsb pdb:5IFS|rcsb pdb:5IFW|rcsb pdb:5KIW|rcsb pdb:5KIY|rcsb pdb:5X4L|rcsb pdb:6G2V|rcsb pdb:6G2W|rcsb pdb:6G2X|rcsb pdb:6G2Y|rcsb pdb:6G2Z|rcsb pdb:6G30|rcsb pdb:6HD0|rcsb pdb:6MCK|rcsb pdb:7BP8|dip:DIP-33543N - - - figure legend:ST2 ST3|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-brain-caudate_nucleus)|taxid:9606(Human brain, caudate nuclear region) - 2020/12/30 2021/01/05 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs9606 rogid:HrjDhdsDcgaf8HEbqqMjUqxPaEs9606 rigid:mveF/eKKR/8+XTujVjV5bTZxTE8 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P60880 uniprotkb:P17600 intact:EBI-524785|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|uniprotkb:B2RAU4|uniprotkb:Q53EM2|uniprotkb:Q5U0B5|uniprotkb:D3DW16|uniprotkb:D3DW17|ensembl:ENSP00000254976 intact:EBI-717274|uniprotkb:O75825|uniprotkb:Q5H9A9|uniprotkb:B1AJQ1|ensembl:ENSP00000295987 psi-mi:snp25_human(display_long)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym)|uniprotkb:SNAP25(gene name)|psi-mi:SNAP25(display_short)|uniprotkb:SNAP(gene name synonym) psi-mi:syn1_human(display_long)|uniprotkb:Synapsin I(gene name synonym)|uniprotkb:Brain protein 4.1(gene name synonym)|uniprotkb:SYN1(gene name)|psi-mi:SYN1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ramos-Miguel et al. (2019) pubmed:30610939|imex:IM-28601 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26578093|imex:IM-28601-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005260865.1|refseq:XP_016883510.1|refseq:NP_003072.2|refseq:NP_570824.1|ensembl:ENSG00000132639(gene)|ensembl:ENST00000254976(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030426"(growth cone)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:P60880|rcsb pdb:1KIL|rcsb pdb:1XTG|rcsb pdb:2N1T|rcsb pdb:3DDA|rcsb pdb:3DDB|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|rcsb pdb:3ZUR|rcsb pdb:5W7I|rcsb pdb:5W7J|rcsb pdb:6JLH|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-422356|reactome:R-HSA-449836|reactome:R-HSA-5250968|reactome:R-HSA-5250971|reactome:R-HSA-5250992|reactome:R-HSA-6798695|reactome:R-HSA-888590|reactome:R-HSA-9662360|refseq:XP_016883511.1|refseq:NP_001309831.1|refseq:NP_001309832.1|refseq:NP_001309833.1|refseq:NP_001309834.1|refseq:NP_001309835.1|refseq:NP_001309836.1|refseq:NP_001309837.1|refseq:NP_001309838.1|refseq:NP_001309839.1|dip:DIP-34554N refseq:NP_008881.2|refseq:NP_598006.1|ensembl:ENSG00000008056(gene)|ensembl:ENST00000295987(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0003779"(actin binding)|go:"GO:0005215"(transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048666"(neuron development)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050808"(synapse organization)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR001359(Synapsin)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016185(PreATP-grasp-like fold)|interpro:IPR019735|interpro:IPR019736|interpro:IPR020897|interpro:IPR020898|interpro:IPR028713|mint:P17600|reactome:R-HSA-181429|reactome:R-HSA-212676|reactome:R-HSA-9662360 - - - figure legend:ST2 ST3|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-brain-caudate_nucleus)|taxid:9606(Human brain, caudate nuclear region) - 2020/12/30 2021/01/05 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs9606 rogid:Ke+bkgUVHDWL6F3z9tPRWOlP+B09606 rigid:mveF/eKKR/8+XTujVjV5bTZxTE8 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P60880 uniprotkb:O95721 intact:EBI-524785|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|uniprotkb:B2RAU4|uniprotkb:Q53EM2|uniprotkb:Q5U0B5|uniprotkb:D3DW16|uniprotkb:D3DW17|ensembl:ENSP00000254976 intact:EBI-490676|ensembl:ENSP00000215730 psi-mi:snp25_human(display_long)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym)|uniprotkb:SNAP25(gene name)|psi-mi:SNAP25(display_short)|uniprotkb:SNAP(gene name synonym) psi-mi:snp29_human(display_long)|uniprotkb:Vesicle-membrane fusion protein SNAP-29(gene name synonym)|uniprotkb:Soluble 29 kDa NSF attachment protein(gene name synonym)|uniprotkb:SNAP29(gene name)|psi-mi:SNAP29(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ramos-Miguel et al. (2019) pubmed:30610939|imex:IM-28601 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26578093|imex:IM-28601-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005260865.1|refseq:XP_016883510.1|refseq:NP_003072.2|refseq:NP_570824.1|ensembl:ENSG00000132639(gene)|ensembl:ENST00000254976(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030426"(growth cone)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:P60880|rcsb pdb:1KIL|rcsb pdb:1XTG|rcsb pdb:2N1T|rcsb pdb:3DDA|rcsb pdb:3DDB|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|rcsb pdb:3ZUR|rcsb pdb:5W7I|rcsb pdb:5W7J|rcsb pdb:6JLH|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-422356|reactome:R-HSA-449836|reactome:R-HSA-5250968|reactome:R-HSA-5250971|reactome:R-HSA-5250992|reactome:R-HSA-6798695|reactome:R-HSA-888590|reactome:R-HSA-9662360|refseq:XP_016883511.1|refseq:NP_001309831.1|refseq:NP_001309832.1|refseq:NP_001309833.1|refseq:NP_001309834.1|refseq:NP_001309835.1|refseq:NP_001309836.1|refseq:NP_001309837.1|refseq:NP_001309838.1|refseq:NP_001309839.1|dip:DIP-34554N refseq:NP_004773.1|ensembl:ENSG00000099940(gene)|ensembl:ENST00000215730(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006903"(vesicle targeting)|go:"GO:0006906"(vesicle fusion)|go:"GO:0015031"(protein transport)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0019905"(syntaxin binding)|go:"GO:0020018"(ciliary pocket membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061025"(membrane fusion)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0098793"(presynapse)|interpro:IPR000727(Target SNARE coiled-coil region)|mint:O95721|rcsb pdb:4WY4|rcsb pdb:7BV6|reactome:R-HSA-6798695|reactome:R-HSA-6811438|dip:DIP-56475N - - - figure legend:ST2 ST3|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-brain-caudate_nucleus)|taxid:9606(Human brain, caudate nuclear region) - 2020/12/30 2021/01/05 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs9606 rogid:4HyjERPnEDdBgiGt70N9oyrMN1k9606 rigid:mveF/eKKR/8+XTujVjV5bTZxTE8 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P60880 uniprotkb:P61764 intact:EBI-524785|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|uniprotkb:B2RAU4|uniprotkb:Q53EM2|uniprotkb:Q5U0B5|uniprotkb:D3DW16|uniprotkb:D3DW17|ensembl:ENSP00000254976 intact:EBI-960169|uniprotkb:Q28208|uniprotkb:Q62759|uniprotkb:Q64320|uniprotkb:Q96TG8|uniprotkb:B1AM97|uniprotkb:Q68CM6|ensembl:ENSP00000362396 psi-mi:snp25_human(display_long)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym)|uniprotkb:SNAP25(gene name)|psi-mi:SNAP25(display_short)|uniprotkb:SNAP(gene name synonym) psi-mi:stxb1_human(display_long)|uniprotkb:STXBP1(gene name)|psi-mi:STXBP1(display_short)|uniprotkb:UNC18A(gene name synonym)|uniprotkb:Protein unc-18 homolog 1(gene name synonym)|uniprotkb:Protein unc-18 homolog A(gene name synonym)|uniprotkb:N-Sec1(gene name synonym)|uniprotkb:p67(gene name synonym)|uniprotkb:MUNC18-1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ramos-Miguel et al. (2019) pubmed:30610939|imex:IM-28601 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26578093|imex:IM-28601-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005260865.1|refseq:XP_016883510.1|refseq:NP_003072.2|refseq:NP_570824.1|ensembl:ENSG00000132639(gene)|ensembl:ENST00000254976(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030426"(growth cone)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:P60880|rcsb pdb:1KIL|rcsb pdb:1XTG|rcsb pdb:2N1T|rcsb pdb:3DDA|rcsb pdb:3DDB|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|rcsb pdb:3ZUR|rcsb pdb:5W7I|rcsb pdb:5W7J|rcsb pdb:6JLH|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-422356|reactome:R-HSA-449836|reactome:R-HSA-5250968|reactome:R-HSA-5250971|reactome:R-HSA-5250992|reactome:R-HSA-6798695|reactome:R-HSA-888590|reactome:R-HSA-9662360|refseq:XP_016883511.1|refseq:NP_001309831.1|refseq:NP_001309832.1|refseq:NP_001309833.1|refseq:NP_001309834.1|refseq:NP_001309835.1|refseq:NP_001309836.1|refseq:NP_001309837.1|refseq:NP_001309838.1|refseq:NP_001309839.1|dip:DIP-34554N refseq:NP_001027392.1|refseq:NP_003156.1|ensembl:ENSG00000136854(gene)|ensembl:ENST00000373299(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0002576"(platelet degranulation)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0005739"(mitochondrion)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007412"(axon target recognition)|go:"GO:0010807"(regulation of synaptic vesicle priming)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030424"(axon)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031630"(regulation of synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035542"(regulation of SNARE complex assembly)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050821"(protein stabilization)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099525"(presynaptic dense core vesicle exocytosis)|go:"GO:0106022"(positive regulation of vesicle docking)|go:"GO:1903296"(positive regulation of glutamate secretion, neurotransmission)|go:"GO:2000367"(regulation of acrosomal vesicle exocytosis)|interpro:IPR001619(Sec1-like protein)|interpro:IPR027482|interpro:IPR036045|interpro:IPR043127|interpro:IPR043154|mint:P61764|rcsb pdb:6L03|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-422356|reactome:R-HSA-6794361|reactome:R-HSA-888590 - - - figure legend:ST2 ST3|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-brain-caudate_nucleus)|taxid:9606(Human brain, caudate nuclear region) - 2020/12/30 2021/01/05 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs9606 rogid:yUYi89hDkfMdQ1BdH52swZQFCLk9606 rigid:mveF/eKKR/8+XTujVjV5bTZxTE8 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P60880 uniprotkb:P46459 intact:EBI-524785|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|uniprotkb:B2RAU4|uniprotkb:Q53EM2|uniprotkb:Q5U0B5|uniprotkb:D3DW16|uniprotkb:D3DW17|ensembl:ENSP00000254976 intact:EBI-712251|ensembl:ENSP00000381293|ensembl:ENSP00000478614|ensembl:ENSP00000481714|uniprotkb:Q8N6D7|uniprotkb:Q9UKZ2|uniprotkb:A8K2D9|uniprotkb:B4DFA2 psi-mi:snp25_human(display_long)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym)|uniprotkb:SNAP25(gene name)|psi-mi:SNAP25(display_short)|uniprotkb:SNAP(gene name synonym) psi-mi:nsf_human(display_long)|uniprotkb:N-ethylmaleimide-sensitive fusion protein(gene name synonym)|uniprotkb:Vesicular-fusion protein NSF(gene name synonym)|uniprotkb:NSF(gene name)|psi-mi:NSF(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ramos-Miguel et al. (2019) pubmed:30610939|imex:IM-28601 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26578093|imex:IM-28601-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005260865.1|refseq:XP_016883510.1|refseq:NP_003072.2|refseq:NP_570824.1|ensembl:ENSG00000132639(gene)|ensembl:ENST00000254976(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030426"(growth cone)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:P60880|rcsb pdb:1KIL|rcsb pdb:1XTG|rcsb pdb:2N1T|rcsb pdb:3DDA|rcsb pdb:3DDB|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|rcsb pdb:3ZUR|rcsb pdb:5W7I|rcsb pdb:5W7J|rcsb pdb:6JLH|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-422356|reactome:R-HSA-449836|reactome:R-HSA-5250968|reactome:R-HSA-5250971|reactome:R-HSA-5250992|reactome:R-HSA-6798695|reactome:R-HSA-888590|reactome:R-HSA-9662360|refseq:XP_016883511.1|refseq:NP_001309831.1|refseq:NP_001309832.1|refseq:NP_001309833.1|refseq:NP_001309834.1|refseq:NP_001309835.1|refseq:NP_001309836.1|refseq:NP_001309837.1|refseq:NP_001309838.1|refseq:NP_001309839.1|dip:DIP-34554N ensembl:ENSG00000073969(gene)|ensembl:ENSG00000276262(gene)|ensembl:ENSG00000278174(gene)|ensembl:ENST00000398238(transcript)|ensembl:ENST00000611398(transcript)|ensembl:ENST00000620290(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0005524"(ATP binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005795"(Golgi stack)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035494"(SNARE complex disassembly)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045026"(plasma membrane fusion)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048211"(Golgi vesicle docking)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR027417|interpro:IPR029067|interpro:IPR039812|interpro:IPR041569|mint:P46459|rcsb pdb:6KZQ|reactome:R-HSA-204005|reactome:R-HSA-416993|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811438|reactome:R-HSA-6811440|refseq:NP_006169.2 - - - figure legend:ST2 ST3|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-brain-caudate_nucleus)|taxid:9606(Human brain, caudate nuclear region) - 2020/12/30 2021/01/05 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs9606 rogid:J5hsoA0RTiQkWrV7nWpnK8Dvxxg9606 rigid:mveF/eKKR/8+XTujVjV5bTZxTE8 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P60880 uniprotkb:P23763 intact:EBI-524785|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|uniprotkb:B2RAU4|uniprotkb:Q53EM2|uniprotkb:Q5U0B5|uniprotkb:D3DW16|uniprotkb:D3DW17|ensembl:ENSP00000254976 intact:EBI-10201335|uniprotkb:Q8IVC9|uniprotkb:Q6FG94|uniprotkb:Q15857|uniprotkb:A8MVP3|uniprotkb:O75468|uniprotkb:D3DUR3|ensembl:ENSP00000379602 psi-mi:snp25_human(display_long)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym)|uniprotkb:SNAP25(gene name)|psi-mi:SNAP25(display_short)|uniprotkb:SNAP(gene name synonym) psi-mi:vamp1_human(display_long)|uniprotkb:VAMP1(gene name)|psi-mi:VAMP1(display_short)|uniprotkb:SYB1(gene name synonym)|uniprotkb:Synaptobrevin-1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ramos-Miguel et al. (2019) pubmed:30610939|imex:IM-28601 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26578093|imex:IM-28601-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005260865.1|refseq:XP_016883510.1|refseq:NP_003072.2|refseq:NP_570824.1|ensembl:ENSG00000132639(gene)|ensembl:ENST00000254976(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030426"(growth cone)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:P60880|rcsb pdb:1KIL|rcsb pdb:1XTG|rcsb pdb:2N1T|rcsb pdb:3DDA|rcsb pdb:3DDB|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|rcsb pdb:3ZUR|rcsb pdb:5W7I|rcsb pdb:5W7J|rcsb pdb:6JLH|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-422356|reactome:R-HSA-449836|reactome:R-HSA-5250968|reactome:R-HSA-5250971|reactome:R-HSA-5250992|reactome:R-HSA-6798695|reactome:R-HSA-888590|reactome:R-HSA-9662360|refseq:XP_016883511.1|refseq:NP_001309831.1|refseq:NP_001309832.1|refseq:NP_001309833.1|refseq:NP_001309834.1|refseq:NP_001309835.1|refseq:NP_001309836.1|refseq:NP_001309837.1|refseq:NP_001309838.1|refseq:NP_001309839.1|dip:DIP-34554N refseq:NP_001284367.1|refseq:NP_055046.1|refseq:NP_058439.1|refseq:NP_954740.1|ensembl:ENSG00000139190(gene)|ensembl:ENST00000396308(transcript)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006906"(vesicle fusion)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001388(Synaptobrevin)|interpro:IPR016444(Synaptobrevin, metazoa/fungi)|interpro:IPR042855|mint:P23763|reactome:R-HSA-5250955|reactome:R-HSA-5250981|reactome:R-HSA-5250989 - - - figure legend:ST2 ST3|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-brain-caudate_nucleus)|taxid:9606(Human brain, caudate nuclear region) - 2020/12/30 2021/01/05 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs9606 rogid:9v35ymtDHKr4CC5KcrjtqLsyMzU9606 rigid:mveF/eKKR/8+XTujVjV5bTZxTE8 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P60880 uniprotkb:Q6PUV4 intact:EBI-524785|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|uniprotkb:B2RAU4|uniprotkb:Q53EM2|uniprotkb:Q5U0B5|uniprotkb:D3DW16|uniprotkb:D3DW17|ensembl:ENSP00000254976 intact:EBI-2689453|uniprotkb:Q13329|uniprotkb:B2RAG2|uniprotkb:Q28184|uniprotkb:O09056|uniprotkb:Q64386|uniprotkb:Q52M15|ensembl:ENSP00000352544|ensembl:ENSP00000377346|ensembl:ENSP00000421825 psi-mi:snp25_human(display_long)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym)|uniprotkb:SNAP25(gene name)|psi-mi:SNAP25(display_short)|uniprotkb:SNAP(gene name synonym) psi-mi:cplx2_human(display_long)|uniprotkb:Complexin II(gene name synonym)|uniprotkb:Synaphin-1(gene name synonym)|uniprotkb:CPLX2(gene name)|psi-mi:CPLX2(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ramos-Miguel et al. (2019) pubmed:30610939|imex:IM-28601 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26578093|imex:IM-28601-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005260865.1|refseq:XP_016883510.1|refseq:NP_003072.2|refseq:NP_570824.1|ensembl:ENSG00000132639(gene)|ensembl:ENST00000254976(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030426"(growth cone)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:P60880|rcsb pdb:1KIL|rcsb pdb:1XTG|rcsb pdb:2N1T|rcsb pdb:3DDA|rcsb pdb:3DDB|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|rcsb pdb:3ZUR|rcsb pdb:5W7I|rcsb pdb:5W7J|rcsb pdb:6JLH|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-422356|reactome:R-HSA-449836|reactome:R-HSA-5250968|reactome:R-HSA-5250971|reactome:R-HSA-5250992|reactome:R-HSA-6798695|reactome:R-HSA-888590|reactome:R-HSA-9662360|refseq:XP_016883511.1|refseq:NP_001309831.1|refseq:NP_001309832.1|refseq:NP_001309833.1|refseq:NP_001309834.1|refseq:NP_001309835.1|refseq:NP_001309836.1|refseq:NP_001309837.1|refseq:NP_001309838.1|refseq:NP_001309839.1|dip:DIP-34554N refseq:XP_011532721.1|refseq:NP_001008221.1|refseq:NP_006641.1|ensembl:ENSG00000145920(gene)|ensembl:ENST00000359546(transcript)|ensembl:ENST00000393745(transcript)|ensembl:ENST00000515094(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007399"(nervous system development)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031201"(SNARE complex)|go:"GO:0031630"(regulation of synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0044305"(calyx of Held)|refseq:XP_005265855.1|refseq:XP_005265856.1|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070033"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex)|go:"GO:0070554"(synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR008849(Synaphin)|mint:Q6PUV4|refseq:XP_016864453.1 - - - figure legend:ST2 ST3|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-brain-caudate_nucleus)|taxid:9606(Human brain, caudate nuclear region) - 2020/12/30 2021/01/05 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs9606 rogid:/ISUMIIknUknBri3qhWULXMF1/09606 rigid:mveF/eKKR/8+XTujVjV5bTZxTE8 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P60880 uniprotkb:P61764 intact:EBI-524785|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|uniprotkb:B2RAU4|uniprotkb:Q53EM2|uniprotkb:Q5U0B5|uniprotkb:D3DW16|uniprotkb:D3DW17|ensembl:ENSP00000254976 intact:EBI-960169|uniprotkb:Q28208|uniprotkb:Q62759|uniprotkb:Q64320|uniprotkb:Q96TG8|uniprotkb:B1AM97|uniprotkb:Q68CM6|ensembl:ENSP00000362396 psi-mi:snp25_human(display_long)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym)|uniprotkb:SNAP25(gene name)|psi-mi:SNAP25(display_short)|uniprotkb:SNAP(gene name synonym) psi-mi:stxb1_human(display_long)|uniprotkb:STXBP1(gene name)|psi-mi:STXBP1(display_short)|uniprotkb:UNC18A(gene name synonym)|uniprotkb:Protein unc-18 homolog 1(gene name synonym)|uniprotkb:Protein unc-18 homolog A(gene name synonym)|uniprotkb:N-Sec1(gene name synonym)|uniprotkb:p67(gene name synonym)|uniprotkb:MUNC18-1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ramos-Miguel et al. (2019) pubmed:30610939|imex:IM-28601 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26578093|imex:IM-28601-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005260865.1|refseq:XP_016883510.1|refseq:NP_003072.2|refseq:NP_570824.1|ensembl:ENSG00000132639(gene)|ensembl:ENST00000254976(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030426"(growth cone)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:P60880|rcsb pdb:1KIL|rcsb pdb:1XTG|rcsb pdb:2N1T|rcsb pdb:3DDA|rcsb pdb:3DDB|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|rcsb pdb:3ZUR|rcsb pdb:5W7I|rcsb pdb:5W7J|rcsb pdb:6JLH|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-422356|reactome:R-HSA-449836|reactome:R-HSA-5250968|reactome:R-HSA-5250971|reactome:R-HSA-5250992|reactome:R-HSA-6798695|reactome:R-HSA-888590|reactome:R-HSA-9662360|refseq:XP_016883511.1|refseq:NP_001309831.1|refseq:NP_001309832.1|refseq:NP_001309833.1|refseq:NP_001309834.1|refseq:NP_001309835.1|refseq:NP_001309836.1|refseq:NP_001309837.1|refseq:NP_001309838.1|refseq:NP_001309839.1|dip:DIP-34554N refseq:NP_001027392.1|refseq:NP_003156.1|ensembl:ENSG00000136854(gene)|ensembl:ENST00000373299(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0002576"(platelet degranulation)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0005739"(mitochondrion)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007412"(axon target recognition)|go:"GO:0010807"(regulation of synaptic vesicle priming)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030424"(axon)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031630"(regulation of synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035542"(regulation of SNARE complex assembly)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050821"(protein stabilization)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099525"(presynaptic dense core vesicle exocytosis)|go:"GO:0106022"(positive regulation of vesicle docking)|go:"GO:1903296"(positive regulation of glutamate secretion, neurotransmission)|go:"GO:2000367"(regulation of acrosomal vesicle exocytosis)|interpro:IPR001619(Sec1-like protein)|interpro:IPR027482|interpro:IPR036045|interpro:IPR043127|interpro:IPR043154|mint:P61764|rcsb pdb:6L03|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-422356|reactome:R-HSA-6794361|reactome:R-HSA-888590 - - - figure legend:ST2 ST3|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-brain-caudate_nucleus)|taxid:9606(Human brain, caudate nuclear region) - 2020/12/30 2021/01/05 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs9606 rogid:yUYi89hDkfMdQ1BdH52swZQFCLk9606 rigid:mveF/eKKR/8+XTujVjV5bTZxTE8 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P60880 uniprotkb:Q86Y82 intact:EBI-524785|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|uniprotkb:B2RAU4|uniprotkb:Q53EM2|uniprotkb:Q5U0B5|uniprotkb:D3DW16|uniprotkb:D3DW17|ensembl:ENSP00000254976 intact:EBI-2691717|uniprotkb:B1AJQ7|uniprotkb:O95564|ensembl:ENSP00000363054 psi-mi:snp25_human(display_long)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym)|uniprotkb:SNAP25(gene name)|psi-mi:SNAP25(display_short)|uniprotkb:SNAP(gene name synonym) psi-mi:stx12_human(display_long)|uniprotkb:STX12(gene name)|psi-mi:STX12(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ramos-Miguel et al. (2019) pubmed:30610939|imex:IM-28601 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26578093|imex:IM-28601-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005260865.1|refseq:XP_016883510.1|refseq:NP_003072.2|refseq:NP_570824.1|ensembl:ENSG00000132639(gene)|ensembl:ENST00000254976(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030426"(growth cone)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:P60880|rcsb pdb:1KIL|rcsb pdb:1XTG|rcsb pdb:2N1T|rcsb pdb:3DDA|rcsb pdb:3DDB|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|rcsb pdb:3ZUR|rcsb pdb:5W7I|rcsb pdb:5W7J|rcsb pdb:6JLH|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-422356|reactome:R-HSA-449836|reactome:R-HSA-5250968|reactome:R-HSA-5250971|reactome:R-HSA-5250992|reactome:R-HSA-6798695|reactome:R-HSA-888590|reactome:R-HSA-9662360|refseq:XP_016883511.1|refseq:NP_001309831.1|refseq:NP_001309832.1|refseq:NP_001309833.1|refseq:NP_001309834.1|refseq:NP_001309835.1|refseq:NP_001309836.1|refseq:NP_001309837.1|refseq:NP_001309838.1|refseq:NP_001309839.1|dip:DIP-34554N refseq:NP_803173.1|ensembl:ENSG00000117758(gene)|ensembl:ENST00000373943(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048278"(vesicle docking)|go:"GO:0050821"(protein stabilization)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0098837"(postsynaptic recycling endosome)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|mint:Q86Y82|rcsb pdb:2DNX|dip:DIP-44225N - - - figure legend:ST2 ST3|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-brain-caudate_nucleus)|taxid:9606(Human brain, caudate nuclear region) - 2020/12/30 2021/01/05 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs9606 rogid:kSTOaE08HK8SpI19dBZRZbOVCGw9606 rigid:mveF/eKKR/8+XTujVjV5bTZxTE8 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P60880 uniprotkb:O15400 intact:EBI-524785|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|uniprotkb:B2RAU4|uniprotkb:Q53EM2|uniprotkb:Q5U0B5|uniprotkb:D3DW16|uniprotkb:D3DW17|ensembl:ENSP00000254976 intact:EBI-3221827|ensembl:ENSP00000356918|uniprotkb:Q5SZW2|uniprotkb:Q96ES9|uniprotkb:E1P579 psi-mi:snp25_human(display_long)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym)|uniprotkb:SNAP25(gene name)|psi-mi:SNAP25(display_short)|uniprotkb:SNAP(gene name synonym) psi-mi:stx7_human(display_long)|uniprotkb:STX7(gene name)|psi-mi:STX7(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ramos-Miguel et al. (2019) pubmed:30610939|imex:IM-28601 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26578093|imex:IM-28601-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005260865.1|refseq:XP_016883510.1|refseq:NP_003072.2|refseq:NP_570824.1|ensembl:ENSG00000132639(gene)|ensembl:ENST00000254976(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030426"(growth cone)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:P60880|rcsb pdb:1KIL|rcsb pdb:1XTG|rcsb pdb:2N1T|rcsb pdb:3DDA|rcsb pdb:3DDB|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|rcsb pdb:3ZUR|rcsb pdb:5W7I|rcsb pdb:5W7J|rcsb pdb:6JLH|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-422356|reactome:R-HSA-449836|reactome:R-HSA-5250968|reactome:R-HSA-5250971|reactome:R-HSA-5250992|reactome:R-HSA-6798695|reactome:R-HSA-888590|reactome:R-HSA-9662360|refseq:XP_016883511.1|refseq:NP_001309831.1|refseq:NP_001309832.1|refseq:NP_001309833.1|refseq:NP_001309834.1|refseq:NP_001309835.1|refseq:NP_001309836.1|refseq:NP_001309837.1|refseq:NP_001309838.1|refseq:NP_001309839.1|dip:DIP-34554N ensembl:ENSG00000079950(gene)|ensembl:ENST00000367941(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001772"(immunological synapse)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031201"(SNARE complex)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042582"(azurophil granule)|go:"GO:0048278"(vesicle docking)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051640"(organelle localization)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070820"(tertiary granule)|go:"GO:0070925"(organelle assembly)|go:"GO:1902685"(positive regulation of receptor localization to synapse)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|mint:O15400|refseq:XP_011534480.1|refseq:NP_003560.2|refseq:NP_001313507.1|refseq:NP_001313508.1|refseq:NP_001313509.1|dip:DIP-57384N - - - figure legend:ST2 ST3|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-brain-caudate_nucleus)|taxid:9606(Human brain, caudate nuclear region) - 2020/12/30 2021/01/05 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs9606 rogid:lFaq26g0qeP7ObMMKexuZamQgps9606 rigid:mveF/eKKR/8+XTujVjV5bTZxTE8 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P60880 uniprotkb:P21579 intact:EBI-524785|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|uniprotkb:B2RAU4|uniprotkb:Q53EM2|uniprotkb:Q5U0B5|uniprotkb:D3DW16|uniprotkb:D3DW17|ensembl:ENSP00000254976 intact:EBI-524909|ensembl:ENSP00000261205|ensembl:ENSP00000376932|ensembl:ENSP00000447575|uniprotkb:Q6AI31 psi-mi:snp25_human(display_long)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym)|uniprotkb:SNAP25(gene name)|psi-mi:SNAP25(display_short)|uniprotkb:SNAP(gene name synonym) psi-mi:syt1_human(display_long)|uniprotkb:Synaptotagmin I(gene name synonym)|uniprotkb:p65(gene name synonym)|uniprotkb:SYT1(gene name)|psi-mi:SYT1(display_short)|uniprotkb:SYT(gene name synonym)|uniprotkb:SVP65(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ramos-Miguel et al. (2019) pubmed:30610939|imex:IM-28601 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26578093|imex:IM-28601-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005260865.1|refseq:XP_016883510.1|refseq:NP_003072.2|refseq:NP_570824.1|ensembl:ENSG00000132639(gene)|ensembl:ENST00000254976(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030426"(growth cone)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:P60880|rcsb pdb:1KIL|rcsb pdb:1XTG|rcsb pdb:2N1T|rcsb pdb:3DDA|rcsb pdb:3DDB|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|rcsb pdb:3ZUR|rcsb pdb:5W7I|rcsb pdb:5W7J|rcsb pdb:6JLH|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-422356|reactome:R-HSA-449836|reactome:R-HSA-5250968|reactome:R-HSA-5250971|reactome:R-HSA-5250992|reactome:R-HSA-6798695|reactome:R-HSA-888590|reactome:R-HSA-9662360|refseq:XP_016883511.1|refseq:NP_001309831.1|refseq:NP_001309832.1|refseq:NP_001309833.1|refseq:NP_001309834.1|refseq:NP_001309835.1|refseq:NP_001309836.1|refseq:NP_001309837.1|refseq:NP_001309838.1|refseq:NP_001309839.1|dip:DIP-34554N refseq:NP_001129277.1|refseq:NP_001129278.1|refseq:NP_005630.1|ensembl:ENSG00000067715(gene)|ensembl:ENST00000261205(transcript)|ensembl:ENST00000393240(transcript)|ensembl:ENST00000552744(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007420"(brain development)|go:"GO:0008021"(synaptic vesicle)|refseq:XP_011537012.1|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030348"(syntaxin-3 binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030424"(axon)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0031045"(dense core granule)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0042584"(chromaffin granule membrane)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048278"(vesicle docking)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051291"(protein heterooligomerization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060201"(clathrin-sculpted acetylcholine transport vesicle membrane)|go:"GO:0060203"(clathrin-sculpted glutamate transport vesicle membrane)|go:"GO:0061202"(clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane)|go:"GO:0061669"(spontaneous neurotransmitter secretion)|go:"GO:0061891"(calcium ion sensor activity)|go:"GO:0070083"(clathrin-sculpted monoamine transport vesicle membrane)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071911"(synchronous neurotransmitter secretion)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098746"(fast, calcium ion-dependent exocytosis of neurotransmitter)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099502"(calcium-dependent activation of synaptic vesicle fusion)|go:"GO:1903235"(positive regulation of calcium ion-dependent exocytosis of neurotransmitter)|go:"GO:1903305"(regulation of regulated secretory pathway)|go:"GO:1903861"(positive regulation of dendrite extension)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|interpro:IPR015428(Synaptotagmin 1,2)|interpro:IPR035892|mint:P21579|rcsb pdb:2K45|rcsb pdb:2K4A|rcsb pdb:2K8M|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017156"(calcium-ion regulated exocytosis)|rcsb pdb:2LHA|rcsb pdb:2N1T|rcsb pdb:2KI6|rcsb pdb:2R83|rcsb pdb:3F00|rcsb pdb:3F01|rcsb pdb:3F04|rcsb pdb:3F05|rcsb pdb:4ISQ|rcsb pdb:4V11|rcsb pdb:6G5F|rcsb pdb:6G5K|rcsb pdb:6QNS|rcsb pdb:6TZ3|rcsb pdb:6U41|rcsb pdb:6U4U|rcsb pdb:6U4W|rcsb pdb:6ZVN|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-5250958|reactome:R-HSA-5250989|reactome:R-HSA-6794361|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-888590|reactome:R-HSA-210500|refseq:XP_016875398.1|dip:DIP-34042N - - - figure legend:ST2 ST3|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-brain-caudate_nucleus)|taxid:9606(Human brain, caudate nuclear region) - 2020/12/30 2021/01/05 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs9606 rogid:oWQJLjUokM2dCvvO+VHVbHUj/WE9606 rigid:mveF/eKKR/8+XTujVjV5bTZxTE8 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P60880 uniprotkb:P63027 intact:EBI-524785|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|uniprotkb:B2RAU4|uniprotkb:Q53EM2|uniprotkb:Q5U0B5|uniprotkb:D3DW16|uniprotkb:D3DW17|ensembl:ENSP00000254976 intact:EBI-520113|uniprotkb:P19065|ensembl:ENSP00000314214|uniprotkb:Q9BUC2 psi-mi:snp25_human(display_long)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym)|uniprotkb:SNAP25(gene name)|psi-mi:SNAP25(display_short)|uniprotkb:SNAP(gene name synonym) psi-mi:vamp2_human(display_long)|uniprotkb:Synaptobrevin-2(gene name synonym)|uniprotkb:VAMP2(gene name)|psi-mi:VAMP2(display_short)|uniprotkb:SYB2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ramos-Miguel et al. (2019) pubmed:30610939|imex:IM-28601 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26578093|imex:IM-28601-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005260865.1|refseq:XP_016883510.1|refseq:NP_003072.2|refseq:NP_570824.1|ensembl:ENSG00000132639(gene)|ensembl:ENST00000254976(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030426"(growth cone)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:P60880|rcsb pdb:1KIL|rcsb pdb:1XTG|rcsb pdb:2N1T|rcsb pdb:3DDA|rcsb pdb:3DDB|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|rcsb pdb:3ZUR|rcsb pdb:5W7I|rcsb pdb:5W7J|rcsb pdb:6JLH|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-422356|reactome:R-HSA-449836|reactome:R-HSA-5250968|reactome:R-HSA-5250971|reactome:R-HSA-5250992|reactome:R-HSA-6798695|reactome:R-HSA-888590|reactome:R-HSA-9662360|refseq:XP_016883511.1|refseq:NP_001309831.1|refseq:NP_001309832.1|refseq:NP_001309833.1|refseq:NP_001309834.1|refseq:NP_001309835.1|refseq:NP_001309836.1|refseq:NP_001309837.1|refseq:NP_001309838.1|refseq:NP_001309839.1|dip:DIP-34554N refseq:NP_055047.2|ensembl:ENSG00000220205(gene)|ensembl:ENST00000316509(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009749"(response to glucose)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017022"(myosin binding)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043308"(eosinophil degranulation)|go:"GO:0043621"(protein self-association)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0060203"(clathrin-sculpted glutamate transport vesicle membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061025"(membrane fusion)|go:"GO:0061202"(clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070033"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex)|go:"GO:0070044"(synaptobrevin 2-SNAP-25-syntaxin-1a complex)|go:"GO:0070083"(clathrin-sculpted monoamine transport vesicle membrane)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:1902259"(regulation of delayed rectifier potassium channel activity)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|interpro:IPR001388(Synaptobrevin)|interpro:IPR016444(Synaptobrevin, metazoa/fungi)|interpro:IPR028717|interpro:IPR042855|mint:P63027|rcsb pdb:3FIE|rcsb pdb:3FII|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|reactome:R-HSA-1445148|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-199992|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-264876|reactome:R-HSA-422356|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-449836|reactome:R-HSA-5250955|reactome:R-HSA-5250958|reactome:R-HSA-5250981|reactome:R-HSA-5250982|reactome:R-HSA-5250989|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-888590|reactome:R-HSA-9609523|reactome:R-HSA-9662360|dip:DIP-39072N - - - figure legend:ST2 ST3|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-brain-caudate_nucleus)|taxid:9606(Human brain, caudate nuclear region) - 2020/12/30 2021/01/05 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs9606 rogid:uuuJXsI5sr7fzjxuBhSYDHJZp9M9606 rigid:mveF/eKKR/8+XTujVjV5bTZxTE8 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P60880 uniprotkb:P61266 intact:EBI-524785|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|uniprotkb:B2RAU4|uniprotkb:Q53EM2|uniprotkb:Q5U0B5|uniprotkb:D3DW16|uniprotkb:D3DW17|ensembl:ENSP00000254976 intact:EBI-9071709|uniprotkb:Q2VPS2|uniprotkb:Q15531|ensembl:ENSP00000215095 psi-mi:snp25_human(display_long)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym)|uniprotkb:SNAP25(gene name)|psi-mi:SNAP25(display_short)|uniprotkb:SNAP(gene name synonym) psi-mi:stx1b_human(display_long)|uniprotkb:STX1B1(gene name synonym)|uniprotkb:STX1B2(gene name synonym)|uniprotkb:Syntaxin-1B1(gene name synonym)|uniprotkb:Syntaxin-1B2(gene name synonym)|uniprotkb:STX1B(gene name)|psi-mi:STX1B(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ramos-Miguel et al. (2019) pubmed:30610939|imex:IM-28601 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26578093|imex:IM-28601-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005260865.1|refseq:XP_016883510.1|refseq:NP_003072.2|refseq:NP_570824.1|ensembl:ENSG00000132639(gene)|ensembl:ENST00000254976(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030426"(growth cone)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:P60880|rcsb pdb:1KIL|rcsb pdb:1XTG|rcsb pdb:2N1T|rcsb pdb:3DDA|rcsb pdb:3DDB|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|rcsb pdb:3ZUR|rcsb pdb:5W7I|rcsb pdb:5W7J|rcsb pdb:6JLH|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-422356|reactome:R-HSA-449836|reactome:R-HSA-5250968|reactome:R-HSA-5250971|reactome:R-HSA-5250992|reactome:R-HSA-6798695|reactome:R-HSA-888590|reactome:R-HSA-9662360|refseq:XP_016883511.1|refseq:NP_001309831.1|refseq:NP_001309832.1|refseq:NP_001309833.1|refseq:NP_001309834.1|refseq:NP_001309835.1|refseq:NP_001309836.1|refseq:NP_001309837.1|refseq:NP_001309838.1|refseq:NP_001309839.1|dip:DIP-34554N refseq:NP_443106.1|go:"GO:0010807"(regulation of synaptic vesicle priming)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030424"(axon)|go:"GO:0031201"(SNARE complex)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0048278"(vesicle docking)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0060025"(regulation of synaptic activity)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1904050"(positive regulation of spontaneous neurotransmitter secretion)|go:"GO:1905302"(negative regulation of macropinocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028669|mint:P61266|reactome:R-HSA-5250971|reactome:R-HSA-5682910|go:"GO:0061669"(spontaneous neurotransmitter secretion)|ensembl:ENSG00000099365(gene)|ensembl:ENST00000215095(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle) - - - figure legend:ST2 ST3|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-brain-caudate_nucleus)|taxid:9606(Human brain, caudate nuclear region) - 2020/12/30 2021/01/05 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs9606 rogid:B3aWVxxX3lZ8hOYK4gxwZupY7g49606 rigid:mveF/eKKR/8+XTujVjV5bTZxTE8 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P60880 uniprotkb:Q16623 intact:EBI-524785|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|uniprotkb:B2RAU4|uniprotkb:Q53EM2|uniprotkb:Q5U0B5|uniprotkb:D3DW16|uniprotkb:D3DW17|ensembl:ENSP00000254976 intact:EBI-712466|uniprotkb:Q7Z5K3|ensembl:ENSP00000222812|uniprotkb:O15447|uniprotkb:O15448|uniprotkb:Q12936|uniprotkb:Q9BPZ6|uniprotkb:Q75MD9 psi-mi:snp25_human(display_long)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym)|uniprotkb:SNAP25(gene name)|psi-mi:SNAP25(display_short)|uniprotkb:SNAP(gene name synonym) psi-mi:stx1a_human(display_long)|uniprotkb:Neuron-specific antigen HPC-1(gene name synonym)|uniprotkb:STX1A(gene name)|psi-mi:STX1A(display_short)|uniprotkb:STX1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ramos-Miguel et al. (2019) pubmed:30610939|imex:IM-28601 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26578093|imex:IM-28601-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005260865.1|refseq:XP_016883510.1|refseq:NP_003072.2|refseq:NP_570824.1|ensembl:ENSG00000132639(gene)|ensembl:ENST00000254976(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030426"(growth cone)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:P60880|rcsb pdb:1KIL|rcsb pdb:1XTG|rcsb pdb:2N1T|rcsb pdb:3DDA|rcsb pdb:3DDB|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|rcsb pdb:3ZUR|rcsb pdb:5W7I|rcsb pdb:5W7J|rcsb pdb:6JLH|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-422356|reactome:R-HSA-449836|reactome:R-HSA-5250968|reactome:R-HSA-5250971|reactome:R-HSA-5250992|reactome:R-HSA-6798695|reactome:R-HSA-888590|reactome:R-HSA-9662360|refseq:XP_016883511.1|refseq:NP_001309831.1|refseq:NP_001309832.1|refseq:NP_001309833.1|refseq:NP_001309834.1|refseq:NP_001309835.1|refseq:NP_001309836.1|refseq:NP_001309837.1|refseq:NP_001309838.1|refseq:NP_001309839.1|dip:DIP-34554N go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070033"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex)|go:"GO:0070044"(synaptobrevin 2-SNAP-25-syntaxin-1a complex)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0047485"(protein N-terminus binding)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028669|mint:Q16623|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-264876|reactome:R-HSA-422356|reactome:R-HSA-449836|reactome:R-HSA-5250971|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-888590|reactome:R-HSA-9609523|reactome:R-HSA-9662360|go:"GO:0048278"(vesicle docking)|ensembl:ENSG00000106089(gene)|ensembl:ENST00000222812(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009629"(response to gravity)|go:"GO:0010701"(positive regulation of norepinephrine secretion)|go:"GO:0010807"(regulation of synaptic vesicle priming)|go:"GO:0012505"(endomembrane system)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016925"(protein sumoylation)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030073"(insulin secretion)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030424"(axon)|go:"GO:0031201"(SNARE complex)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032028"(myosin head/neck binding)|go:"GO:0032940"(secretion by cell)|go:"GO:0033605"(positive regulation of catecholamine secretion)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043008"(ATP-dependent protein binding)|refseq:NP_001159375.1|refseq:NP_004594.1|dip:DIP-390N - - - figure legend:ST2 ST3|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-brain-caudate_nucleus)|taxid:9606(Human brain, caudate nuclear region) - 2020/12/30 2021/01/05 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs9606 rogid:2OJ1A7RC63MTlOJmpv/jPx4IvGE9606 rigid:mveF/eKKR/8+XTujVjV5bTZxTE8 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P60880 uniprotkb:Q99719 intact:EBI-524785|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|uniprotkb:B2RAU4|uniprotkb:Q53EM2|uniprotkb:Q5U0B5|uniprotkb:D3DW16|uniprotkb:D3DW17|ensembl:ENSP00000254976 intact:EBI-373345|uniprotkb:O15251|uniprotkb:Q96MY5|ensembl:ENSP00000391311 psi-mi:snp25_human(display_long)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym)|uniprotkb:SNAP25(gene name)|psi-mi:SNAP25(display_short)|uniprotkb:SNAP(gene name synonym) psi-mi:sept5_human(display_long)|uniprotkb:SEPTIN5(gene name)|psi-mi:SEPTIN5(display_short)|uniprotkb:Cell division control-related protein 1(gene name synonym)|uniprotkb:PNUTL1(gene name synonym)|uniprotkb:Peanut-like protein 1(gene name synonym)|uniprotkb:SEPT5(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ramos-Miguel et al. (2019) pubmed:30610939|imex:IM-28601 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26578142|imex:IM-28601-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005260865.1|refseq:XP_016883510.1|refseq:NP_003072.2|refseq:NP_570824.1|ensembl:ENSG00000132639(gene)|ensembl:ENST00000254976(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030426"(growth cone)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:P60880|rcsb pdb:1KIL|rcsb pdb:1XTG|rcsb pdb:2N1T|rcsb pdb:3DDA|rcsb pdb:3DDB|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|rcsb pdb:3ZUR|rcsb pdb:5W7I|rcsb pdb:5W7J|rcsb pdb:6JLH|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-422356|reactome:R-HSA-449836|reactome:R-HSA-5250968|reactome:R-HSA-5250971|reactome:R-HSA-5250992|reactome:R-HSA-6798695|reactome:R-HSA-888590|reactome:R-HSA-9662360|refseq:XP_016883511.1|refseq:NP_001309831.1|refseq:NP_001309832.1|refseq:NP_001309833.1|refseq:NP_001309834.1|refseq:NP_001309835.1|refseq:NP_001309836.1|refseq:NP_001309837.1|refseq:NP_001309838.1|refseq:NP_001309839.1|dip:DIP-34554N refseq:NP_002679.2|refseq:NP_001009939.1|ensembl:ENSG00000184702(gene)|ensembl:ENST00000455784(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005940"(septin ring)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0030534"(adult behavior)|go:"GO:0031105"(septin complex)|go:"GO:0032153"(cell division site)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035176"(social behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR016491(Septin)|interpro:IPR027417|interpro:IPR030379|interpro:IPR030647|mint:Q99719|rcsb pdb:6WCU|dip:DIP-31201N - - crc64:47054765DEA10D33 figure legend:F3A|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-brain-caudate_nucleus)|taxid:9606(Human brain, caudate nuclear region) - 2020/12/30 2020/12/30 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs9606 rogid:kubhD1O+WmJeDWTlX+rcjpP9yRc9606 rigid:2NhVc1yFZZgmoiva9SuhPlVYyt4 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P60880 uniprotkb:P84077 intact:EBI-524785|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|uniprotkb:B2RAU4|uniprotkb:Q53EM2|uniprotkb:Q5U0B5|uniprotkb:D3DW16|uniprotkb:D3DW17|ensembl:ENSP00000254976 intact:EBI-447171|uniprotkb:P10947|uniprotkb:P32889|ensembl:ENSP00000272102|ensembl:ENSP00000440005|ensembl:ENSP00000442980 psi-mi:snp25_human(display_long)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym)|uniprotkb:SNAP25(gene name)|psi-mi:SNAP25(display_short)|uniprotkb:SNAP(gene name synonym) psi-mi:arf1_human(display_long)|uniprotkb:ARF1(gene name)|psi-mi:ARF1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ramos-Miguel et al. (2019) pubmed:30610939|imex:IM-28601 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26578142|imex:IM-28601-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005260865.1|refseq:XP_016883510.1|refseq:NP_003072.2|refseq:NP_570824.1|ensembl:ENSG00000132639(gene)|ensembl:ENST00000254976(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030426"(growth cone)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:P60880|rcsb pdb:1KIL|rcsb pdb:1XTG|rcsb pdb:2N1T|rcsb pdb:3DDA|rcsb pdb:3DDB|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|rcsb pdb:3ZUR|rcsb pdb:5W7I|rcsb pdb:5W7J|rcsb pdb:6JLH|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-422356|reactome:R-HSA-449836|reactome:R-HSA-5250968|reactome:R-HSA-5250971|reactome:R-HSA-5250992|reactome:R-HSA-6798695|reactome:R-HSA-888590|reactome:R-HSA-9662360|refseq:XP_016883511.1|refseq:NP_001309831.1|refseq:NP_001309832.1|refseq:NP_001309833.1|refseq:NP_001309834.1|refseq:NP_001309835.1|refseq:NP_001309836.1|refseq:NP_001309837.1|refseq:NP_001309838.1|refseq:NP_001309839.1|dip:DIP-34554N refseq:NP_001019397.1|refseq:NP_001019398.1|refseq:NP_001019399.1|refseq:NP_001649.1|dip:DIP-31597N|ensembl:ENSG00000143761(gene)|ensembl:ENST00000272102(transcript)|ensembl:ENST00000540651(transcript)|ensembl:ENST00000541182(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005770"(late endosome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007015"(actin filament organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019003"(GDP binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0043005"(neuron projection)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0055108"(Golgi to transport vesicle transport)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070142"(synaptic vesicle budding)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097212"(lysosomal membrane organization)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902307"(positive regulation of sodium ion transmembrane transport)|go:"GO:1902824"(positive regulation of late endosome to lysosome transport)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:1903725"(regulation of phospholipid metabolic process)|go:"GO:1990386"(mitotic cleavage furrow ingression)|go:"GO:1990583"(phospholipase D activator activity)|interpro:IPR005225(Small GTP-binding protein)|go:"GO:1902953"(positive regulation of ER to Golgi vesicle-mediated transport)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|mint:P84077|rcsb pdb:1HUR|rcsb pdb:1RE0|rcsb pdb:1U81|rcsb pdb:3O47|rcsb pdb:4HMY|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|rcsb pdb:6FAE|rcsb pdb:7MGE|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-167590|reactome:R-HSA-199992|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811438|reactome:R-HSA-8950505 - - - figure legend:F3A|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-brain-caudate_nucleus)|taxid:9606(Human brain, caudate nuclear region) - 2020/12/30 2020/12/30 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs9606 rogid:zray9asm6VonxpuJpv0dRBspPt89606 rigid:2NhVc1yFZZgmoiva9SuhPlVYyt4 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P84077 uniprotkb:Q99719 intact:EBI-447171|uniprotkb:P10947|uniprotkb:P32889|ensembl:ENSP00000272102|ensembl:ENSP00000440005|ensembl:ENSP00000442980 intact:EBI-373345|uniprotkb:O15251|uniprotkb:Q96MY5|ensembl:ENSP00000391311 psi-mi:arf1_human(display_long)|uniprotkb:ARF1(gene name)|psi-mi:ARF1(display_short) psi-mi:sept5_human(display_long)|uniprotkb:SEPTIN5(gene name)|psi-mi:SEPTIN5(display_short)|uniprotkb:Cell division control-related protein 1(gene name synonym)|uniprotkb:PNUTL1(gene name synonym)|uniprotkb:Peanut-like protein 1(gene name synonym)|uniprotkb:SEPT5(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ramos-Miguel et al. (2019) pubmed:30610939|imex:IM-28601 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26578147|imex:IM-28601-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001019397.1|refseq:NP_001019398.1|refseq:NP_001019399.1|refseq:NP_001649.1|dip:DIP-31597N|ensembl:ENSG00000143761(gene)|ensembl:ENST00000272102(transcript)|ensembl:ENST00000540651(transcript)|ensembl:ENST00000541182(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005770"(late endosome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007015"(actin filament organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019003"(GDP binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0043005"(neuron projection)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0055108"(Golgi to transport vesicle transport)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070142"(synaptic vesicle budding)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097212"(lysosomal membrane organization)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902307"(positive regulation of sodium ion transmembrane transport)|go:"GO:1902824"(positive regulation of late endosome to lysosome transport)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:1903725"(regulation of phospholipid metabolic process)|go:"GO:1990386"(mitotic cleavage furrow ingression)|go:"GO:1990583"(phospholipase D activator activity)|interpro:IPR005225(Small GTP-binding protein)|go:"GO:1902953"(positive regulation of ER to Golgi vesicle-mediated transport)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|mint:P84077|rcsb pdb:1HUR|rcsb pdb:1RE0|rcsb pdb:1U81|rcsb pdb:3O47|rcsb pdb:4HMY|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|rcsb pdb:6FAE|rcsb pdb:7MGE|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-167590|reactome:R-HSA-199992|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811438|reactome:R-HSA-8950505 refseq:NP_002679.2|refseq:NP_001009939.1|ensembl:ENSG00000184702(gene)|ensembl:ENST00000455784(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005940"(septin ring)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0030534"(adult behavior)|go:"GO:0031105"(septin complex)|go:"GO:0032153"(cell division site)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035176"(social behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR016491(Septin)|interpro:IPR027417|interpro:IPR030379|interpro:IPR030647|mint:Q99719|rcsb pdb:6WCU|dip:DIP-31201N - - crc64:47054765DEA10D33 figure legend:F3A|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-brain-caudate_nucleus)|taxid:9606(Human brain, caudate nuclear region) - 2020/12/30 2020/12/30 rogid:zray9asm6VonxpuJpv0dRBspPt89606 rogid:kubhD1O+WmJeDWTlX+rcjpP9yRc9606 rigid:2NhVc1yFZZgmoiva9SuhPlVYyt4 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P84077 uniprotkb:P60880 intact:EBI-447171|uniprotkb:P10947|uniprotkb:P32889|ensembl:ENSP00000272102|ensembl:ENSP00000440005|ensembl:ENSP00000442980 intact:EBI-524785|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|uniprotkb:B2RAU4|uniprotkb:Q53EM2|uniprotkb:Q5U0B5|uniprotkb:D3DW16|uniprotkb:D3DW17|ensembl:ENSP00000254976 psi-mi:arf1_human(display_long)|uniprotkb:ARF1(gene name)|psi-mi:ARF1(display_short) psi-mi:snp25_human(display_long)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym)|uniprotkb:SNAP25(gene name)|psi-mi:SNAP25(display_short)|uniprotkb:SNAP(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ramos-Miguel et al. (2019) pubmed:30610939|imex:IM-28601 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-26578147|imex:IM-28601-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001019397.1|refseq:NP_001019398.1|refseq:NP_001019399.1|refseq:NP_001649.1|dip:DIP-31597N|ensembl:ENSG00000143761(gene)|ensembl:ENST00000272102(transcript)|ensembl:ENST00000540651(transcript)|ensembl:ENST00000541182(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005770"(late endosome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007015"(actin filament organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019003"(GDP binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0043005"(neuron projection)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0055108"(Golgi to transport vesicle transport)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070142"(synaptic vesicle budding)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097212"(lysosomal membrane organization)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902307"(positive regulation of sodium ion transmembrane transport)|go:"GO:1902824"(positive regulation of late endosome to lysosome transport)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:1903725"(regulation of phospholipid metabolic process)|go:"GO:1990386"(mitotic cleavage furrow ingression)|go:"GO:1990583"(phospholipase D activator activity)|interpro:IPR005225(Small GTP-binding protein)|go:"GO:1902953"(positive regulation of ER to Golgi vesicle-mediated transport)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|mint:P84077|rcsb pdb:1HUR|rcsb pdb:1RE0|rcsb pdb:1U81|rcsb pdb:3O47|rcsb pdb:4HMY|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|rcsb pdb:6FAE|rcsb pdb:7MGE|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-167590|reactome:R-HSA-199992|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811438|reactome:R-HSA-8950505 refseq:XP_005260865.1|refseq:XP_016883510.1|refseq:NP_003072.2|refseq:NP_570824.1|ensembl:ENSG00000132639(gene)|ensembl:ENST00000254976(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030426"(growth cone)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:P60880|rcsb pdb:1KIL|rcsb pdb:1XTG|rcsb pdb:2N1T|rcsb pdb:3DDA|rcsb pdb:3DDB|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|rcsb pdb:3ZUR|rcsb pdb:5W7I|rcsb pdb:5W7J|rcsb pdb:6JLH|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-422356|reactome:R-HSA-449836|reactome:R-HSA-5250968|reactome:R-HSA-5250971|reactome:R-HSA-5250992|reactome:R-HSA-6798695|reactome:R-HSA-888590|reactome:R-HSA-9662360|refseq:XP_016883511.1|refseq:NP_001309831.1|refseq:NP_001309832.1|refseq:NP_001309833.1|refseq:NP_001309834.1|refseq:NP_001309835.1|refseq:NP_001309836.1|refseq:NP_001309837.1|refseq:NP_001309838.1|refseq:NP_001309839.1|dip:DIP-34554N - - - figure legend:F3A|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-brain-caudate_nucleus)|taxid:9606(Human brain, caudate nuclear region) - 2020/12/30 2020/12/30 rogid:zray9asm6VonxpuJpv0dRBspPt89606 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs9606 rigid:2NhVc1yFZZgmoiva9SuhPlVYyt4 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P84077 uniprotkb:P60880 intact:EBI-447171|uniprotkb:P10947|uniprotkb:P32889|ensembl:ENSP00000272102|ensembl:ENSP00000440005|ensembl:ENSP00000442980 intact:EBI-524785|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|uniprotkb:B2RAU4|uniprotkb:Q53EM2|uniprotkb:Q5U0B5|uniprotkb:D3DW16|uniprotkb:D3DW17|ensembl:ENSP00000254976 psi-mi:arf1_human(display_long)|uniprotkb:ARF1(gene name)|psi-mi:ARF1(display_short) psi-mi:snp25_human(display_long)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym)|uniprotkb:SNAP25(gene name)|psi-mi:SNAP25(display_short)|uniprotkb:SNAP(gene name synonym) psi-mi:"MI:0029"(cosedimentation through density gradient) Ramos-Miguel et al. (2019) pubmed:30610939|imex:IM-28601 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-26578163|imex:IM-28601-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001019397.1|refseq:NP_001019398.1|refseq:NP_001019399.1|refseq:NP_001649.1|dip:DIP-31597N|ensembl:ENSG00000143761(gene)|ensembl:ENST00000272102(transcript)|ensembl:ENST00000540651(transcript)|ensembl:ENST00000541182(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005770"(late endosome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007015"(actin filament organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019003"(GDP binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0043005"(neuron projection)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0055108"(Golgi to transport vesicle transport)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070142"(synaptic vesicle budding)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097212"(lysosomal membrane organization)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902307"(positive regulation of sodium ion transmembrane transport)|go:"GO:1902824"(positive regulation of late endosome to lysosome transport)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:1903725"(regulation of phospholipid metabolic process)|go:"GO:1990386"(mitotic cleavage furrow ingression)|go:"GO:1990583"(phospholipase D activator activity)|interpro:IPR005225(Small GTP-binding protein)|go:"GO:1902953"(positive regulation of ER to Golgi vesicle-mediated transport)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|mint:P84077|rcsb pdb:1HUR|rcsb pdb:1RE0|rcsb pdb:1U81|rcsb pdb:3O47|rcsb pdb:4HMY|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|rcsb pdb:6FAE|rcsb pdb:7MGE|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-167590|reactome:R-HSA-199992|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811438|reactome:R-HSA-8950505 refseq:XP_005260865.1|refseq:XP_016883510.1|refseq:NP_003072.2|refseq:NP_570824.1|ensembl:ENSG00000132639(gene)|ensembl:ENST00000254976(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030426"(growth cone)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:P60880|rcsb pdb:1KIL|rcsb pdb:1XTG|rcsb pdb:2N1T|rcsb pdb:3DDA|rcsb pdb:3DDB|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|rcsb pdb:3ZUR|rcsb pdb:5W7I|rcsb pdb:5W7J|rcsb pdb:6JLH|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-422356|reactome:R-HSA-449836|reactome:R-HSA-5250968|reactome:R-HSA-5250971|reactome:R-HSA-5250992|reactome:R-HSA-6798695|reactome:R-HSA-888590|reactome:R-HSA-9662360|refseq:XP_016883511.1|refseq:NP_001309831.1|refseq:NP_001309832.1|refseq:NP_001309833.1|refseq:NP_001309834.1|refseq:NP_001309835.1|refseq:NP_001309836.1|refseq:NP_001309837.1|refseq:NP_001309838.1|refseq:NP_001309839.1|dip:DIP-34554N go:"GO:0043005"(neuron projection) - - figure legend:F3B|comment:Subcellular fractionation experiments showed that the ARF1-SNAP25 association is anatomically relevant, as both ARF1 species were present in the synaptosomal preparations .|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-brain-cortex)|taxid:9606(Homo sapiens brain cortex) - 2020/12/30 2020/12/30 rogid:zray9asm6VonxpuJpv0dRBspPt89606 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs9606 rigid:MLIjiRNIQJVTojNBXDNC4uCZyMU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P84077 uniprotkb:P60880 intact:EBI-447171|uniprotkb:P10947|uniprotkb:P32889|ensembl:ENSP00000272102|ensembl:ENSP00000440005|ensembl:ENSP00000442980 intact:EBI-524785|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|uniprotkb:B2RAU4|uniprotkb:Q53EM2|uniprotkb:Q5U0B5|uniprotkb:D3DW16|uniprotkb:D3DW17|ensembl:ENSP00000254976 psi-mi:arf1_human(display_long)|uniprotkb:ARF1(gene name)|psi-mi:ARF1(display_short) psi-mi:snp25_human(display_long)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym)|uniprotkb:SNAP25(gene name)|psi-mi:SNAP25(display_short)|uniprotkb:SNAP(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Ramos-Miguel et al. (2019) pubmed:30610939|imex:IM-28601 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-26578179|imex:IM-28601-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001019397.1|refseq:NP_001019398.1|refseq:NP_001019399.1|refseq:NP_001649.1|dip:DIP-31597N|ensembl:ENSG00000143761(gene)|ensembl:ENST00000272102(transcript)|ensembl:ENST00000540651(transcript)|ensembl:ENST00000541182(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005770"(late endosome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007015"(actin filament organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019003"(GDP binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0043005"(neuron projection)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0055108"(Golgi to transport vesicle transport)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070142"(synaptic vesicle budding)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097212"(lysosomal membrane organization)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902307"(positive regulation of sodium ion transmembrane transport)|go:"GO:1902824"(positive regulation of late endosome to lysosome transport)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:1903725"(regulation of phospholipid metabolic process)|go:"GO:1990386"(mitotic cleavage furrow ingression)|go:"GO:1990583"(phospholipase D activator activity)|interpro:IPR005225(Small GTP-binding protein)|go:"GO:1902953"(positive regulation of ER to Golgi vesicle-mediated transport)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|mint:P84077|rcsb pdb:1HUR|rcsb pdb:1RE0|rcsb pdb:1U81|rcsb pdb:3O47|rcsb pdb:4HMY|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|rcsb pdb:6FAE|rcsb pdb:7MGE|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-167590|reactome:R-HSA-199992|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811438|reactome:R-HSA-8950505 refseq:XP_005260865.1|refseq:XP_016883510.1|refseq:NP_003072.2|refseq:NP_570824.1|ensembl:ENSG00000132639(gene)|ensembl:ENST00000254976(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030426"(growth cone)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:P60880|rcsb pdb:1KIL|rcsb pdb:1XTG|rcsb pdb:2N1T|rcsb pdb:3DDA|rcsb pdb:3DDB|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|rcsb pdb:3ZUR|rcsb pdb:5W7I|rcsb pdb:5W7J|rcsb pdb:6JLH|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-422356|reactome:R-HSA-449836|reactome:R-HSA-5250968|reactome:R-HSA-5250971|reactome:R-HSA-5250992|reactome:R-HSA-6798695|reactome:R-HSA-888590|reactome:R-HSA-9662360|refseq:XP_016883511.1|refseq:NP_001309831.1|refseq:NP_001309832.1|refseq:NP_001309833.1|refseq:NP_001309834.1|refseq:NP_001309835.1|refseq:NP_001309836.1|refseq:NP_001309837.1|refseq:NP_001309838.1|refseq:NP_001309839.1|dip:DIP-34554N go:"GO:0098793"(presynapse)|go:"GO:0043195"(terminal bouton)|go:"GO:0060076"(excitatory synapse) - - figure legend:F3C|comment:Subcellular fractionation experiments showed that the ARF1-SNAP25 association is anatomically relevant, as both ARF1 species were present in the synaptosomal preparations .|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-brain)|taxid:9606(Homo sapiens brain) - 2020/12/30 2020/12/30 rogid:zray9asm6VonxpuJpv0dRBspPt89606 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs9606 rigid:MLIjiRNIQJVTojNBXDNC4uCZyMU false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining)