#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O60494	uniprotkb:Q9BXJ7	intact:EBI-3953632|uniprotkb:B0YIZ4|uniprotkb:Q5VTA6|uniprotkb:Q96RU9|ensembl:ENSP00000367064	intact:EBI-11510881|uniprotkb:Q6UX83|ensembl:ENSP00000299155	psi-mi:cubn_human(display_long)|uniprotkb:CUBN(gene name)|psi-mi:CUBN(display_short)|uniprotkb:IFCR(gene name synonym)|uniprotkb:460 kDa receptor(gene name synonym)|uniprotkb:Intestinal intrinsic factor receptor(gene name synonym)|uniprotkb:Intrinsic factor-cobalamin receptor(gene name synonym)|uniprotkb:Intrinsic factor-vitamin B12 receptor(gene name synonym)	psi-mi:amnls_human(display_long)|uniprotkb:AMN(gene name)|psi-mi:AMN(display_short)|uniprotkb:UNQ513/PRO1028(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	Larsen et al. (2018)	imex:IM-28139|pubmed:30523278	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25591944|imex:IM-28139-1|wwpdb:6gje	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001072.2|ensembl:ENSG00000107611(gene)|ensembl:ENST00000377833(transcript)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009617"(response to bacterium)|go:"GO:0010008"(endosome membrane)|go:"GO:0015889"(cobalamin transport)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0031419"(cobalamin binding)|go:"GO:0031526"(brush border membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043235"(receptor complex)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000859(CUB)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR018097|interpro:IPR024731|interpro:IPR028876|interpro:IPR035914|rcsb pdb:3KQ4|rcsb pdb:6GJE|reactome:R-HSA-196741|reactome:R-HSA-196791|reactome:R-HSA-3359462|reactome:R-HSA-3359463|reactome:R-HSA-8964011|dip:DIP-58583N	refseq:NP_112205.2|ensembl:ENSG00000166126(gene)|ensembl:ENST00000299155(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007588"(excretion)|go:"GO:0008104"(protein localization)|go:"GO:0010008"(endosome membrane)|go:"GO:0015889"(cobalamin transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031526"(brush border membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0070062"(extracellular exosome)|interpro:IPR026112|rcsb pdb:6GJE|reactome:R-HSA-196741|reactome:R-HSA-3359462|reactome:R-HSA-3359463|reactome:R-HSA-8964011	-	-	-	figure legend:Table 1|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2020/04/29	2020/04/30	rogid:YvJJjMkqNOU+Ktis0SvKbGUU46w9606	rogid:uLKBOoHITIOkVOH8K9bYvXAII5E9606	rigid:RC2D6jtfmsQ4u0MKSW9TS74KVQY	false	sufficient binding region:26-135	sufficient binding region:20-357	3	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:F1RWC3	uniprotkb:F1RWC3	intact:EBI-25591961	intact:EBI-25591961	psi-mi:cubn_pig(display_long)|uniprotkb:CUBN(gene name)|psi-mi:CUBN(display_short)|uniprotkb:IFCR(gene name synonym)|uniprotkb:Intrinsic factor-cobalamin receptor(gene name synonym)	psi-mi:cubn_pig(display_long)|uniprotkb:CUBN(gene name)|psi-mi:CUBN(display_short)|uniprotkb:IFCR(gene name synonym)|uniprotkb:Intrinsic factor-cobalamin receptor(gene name synonym)	psi-mi:"MI:0040"(electron microscopy)	Larsen et al. (2018)	imex:IM-28139|pubmed:30523278	taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)")	taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25591994|imex:IM-28139-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005509"(calcium ion binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0015031"(protein transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031419"(cobalamin binding)|go:"GO:0038024"(cargo receptor activity)|interpro:IPR000859(CUB)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR018097|interpro:IPR024731|interpro:IPR009030(Growth factor, receptor)|interpro:IPR035914|interpro:IPR028876	go:"GO:0005509"(calcium ion binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0015031"(protein transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031419"(cobalamin binding)|go:"GO:0038024"(cargo receptor activity)|interpro:IPR000859(CUB)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR018097|interpro:IPR024731|interpro:IPR009030(Growth factor, receptor)|interpro:IPR035914|interpro:IPR028876	go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 4A, 4B|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/04/29	2020/07/06	rogid:0xEorZ2MxUlhgnoXndh/jjKN5tE9823	rogid:0xEorZ2MxUlhgnoXndh/jjKN5tE9823	rigid:YGcXdkAJ3rrKuQ3nzAitR7O92hk	false	-	-	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60494	uniprotkb:Q9BXJ7	intact:EBI-3953632|uniprotkb:B0YIZ4|uniprotkb:Q5VTA6|uniprotkb:Q96RU9|ensembl:ENSP00000367064	intact:EBI-11510881|uniprotkb:Q6UX83|ensembl:ENSP00000299155	psi-mi:cubn_human(display_long)|uniprotkb:CUBN(gene name)|psi-mi:CUBN(display_short)|uniprotkb:IFCR(gene name synonym)|uniprotkb:460 kDa receptor(gene name synonym)|uniprotkb:Intestinal intrinsic factor receptor(gene name synonym)|uniprotkb:Intrinsic factor-cobalamin receptor(gene name synonym)|uniprotkb:Intrinsic factor-vitamin B12 receptor(gene name synonym)	psi-mi:amnls_human(display_long)|uniprotkb:AMN(gene name)|psi-mi:AMN(display_short)|uniprotkb:UNQ513/PRO1028(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Larsen et al. (2018)	imex:IM-28139|pubmed:30523278	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25592265|imex:IM-28139-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001072.2|ensembl:ENSG00000107611(gene)|ensembl:ENST00000377833(transcript)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009617"(response to bacterium)|go:"GO:0010008"(endosome membrane)|go:"GO:0015889"(cobalamin transport)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0031419"(cobalamin binding)|go:"GO:0031526"(brush border membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043235"(receptor complex)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000859(CUB)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR018097|interpro:IPR024731|interpro:IPR028876|interpro:IPR035914|rcsb pdb:3KQ4|rcsb pdb:6GJE|reactome:R-HSA-196741|reactome:R-HSA-196791|reactome:R-HSA-3359462|reactome:R-HSA-3359463|reactome:R-HSA-8964011|dip:DIP-58583N	refseq:NP_112205.2|ensembl:ENSG00000166126(gene)|ensembl:ENST00000299155(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007588"(excretion)|go:"GO:0008104"(protein localization)|go:"GO:0010008"(endosome membrane)|go:"GO:0015889"(cobalamin transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031526"(brush border membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0070062"(extracellular exosome)|interpro:IPR026112|rcsb pdb:6GJE|reactome:R-HSA-196741|reactome:R-HSA-3359462|reactome:R-HSA-3359463|reactome:R-HSA-8964011	-	-	-	figure legend:Fig.5C, Supp Fig.4|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho_k1)|taxid:10029(Cricetulus griseus ovary K1)	-	2020/04/29	2020/04/30	rogid:YvJJjMkqNOU+Ktis0SvKbGUU46w9606	rogid:uLKBOoHITIOkVOH8K9bYvXAII5E9606	rigid:RC2D6jtfmsQ4u0MKSW9TS74KVQY	false	sufficient binding region:1-1389	his tag:c-c|v5 tag:c-c|mutation disrupting interaction strength:35-35|mutation with no effect:37-37|mutation with no effect:41-41|mutation disrupting interaction strength:41-41,35-35|mutation with no effect:37-37,41-41	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O60494	uniprotkb:Q9BXJ7	intact:EBI-3953632|uniprotkb:B0YIZ4|uniprotkb:Q5VTA6|uniprotkb:Q96RU9|ensembl:ENSP00000367064	intact:EBI-11510881|uniprotkb:Q6UX83|ensembl:ENSP00000299155	psi-mi:cubn_human(display_long)|uniprotkb:CUBN(gene name)|psi-mi:CUBN(display_short)|uniprotkb:IFCR(gene name synonym)|uniprotkb:460 kDa receptor(gene name synonym)|uniprotkb:Intestinal intrinsic factor receptor(gene name synonym)|uniprotkb:Intrinsic factor-cobalamin receptor(gene name synonym)|uniprotkb:Intrinsic factor-vitamin B12 receptor(gene name synonym)	psi-mi:amnls_human(display_long)|uniprotkb:AMN(gene name)|psi-mi:AMN(display_short)|uniprotkb:UNQ513/PRO1028(orf name)	psi-mi:"MI:0096"(pull down)	Larsen et al. (2018)	imex:IM-28139|pubmed:30523278	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25592293|imex:IM-28139-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001072.2|ensembl:ENSG00000107611(gene)|ensembl:ENST00000377833(transcript)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009617"(response to bacterium)|go:"GO:0010008"(endosome membrane)|go:"GO:0015889"(cobalamin transport)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0031419"(cobalamin binding)|go:"GO:0031526"(brush border membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043235"(receptor complex)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000859(CUB)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR018097|interpro:IPR024731|interpro:IPR028876|interpro:IPR035914|rcsb pdb:3KQ4|rcsb pdb:6GJE|reactome:R-HSA-196741|reactome:R-HSA-196791|reactome:R-HSA-3359462|reactome:R-HSA-3359463|reactome:R-HSA-8964011|dip:DIP-58583N	refseq:NP_112205.2|ensembl:ENSG00000166126(gene)|ensembl:ENST00000299155(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007588"(excretion)|go:"GO:0008104"(protein localization)|go:"GO:0010008"(endosome membrane)|go:"GO:0015889"(cobalamin transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031526"(brush border membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0070062"(extracellular exosome)|interpro:IPR026112|rcsb pdb:6GJE|reactome:R-HSA-196741|reactome:R-HSA-3359462|reactome:R-HSA-3359463|reactome:R-HSA-8964011	-	-	-	figure legend:Supp Fig.5|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2020/04/29	2020/04/30	rogid:YvJJjMkqNOU+Ktis0SvKbGUU46w9606	rogid:uLKBOoHITIOkVOH8K9bYvXAII5E9606	rigid:RC2D6jtfmsQ4u0MKSW9TS74KVQY	false	sufficient binding region:26-135	sufficient binding region:20-357|his tag:?-?|tag:?-?|mutation disrupting interaction strength:59-59|mutation disrupting interaction strength:234-234|mutation with no effect:41-41|mutation disrupting interaction strength:69-69|mutation disrupting interaction strength:254-254	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)