#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P59594 uniprotkb:P59594 intact:EBI-15582614|intact:EBI-16063777|uniprotkb:Q6QU82|uniprotkb:Q7T696|uniprotkb:Q7TA19|uniprotkb:Q7TFA2|uniprotkb:Q7TFB1|uniprotkb:Q80BV6 intact:EBI-15582614|intact:EBI-16063777|uniprotkb:Q6QU82|uniprotkb:Q7T696|uniprotkb:Q7TA19|uniprotkb:Q7TFA2|uniprotkb:Q7TFB1|uniprotkb:Q80BV6 psi-mi:spike_sars(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name) psi-mi:spike_sars(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name) psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction) Kirchdoerfer et al. (2018) pubmed:30356097|imex:IM-28205 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-25761475|wwpdb:6CRV|emdb:7573|imex:IM-28205-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR032500|interpro:IPR036326|interpro:IPR042578|interpro:IPR043002|interpro:IPR043473|interpro:IPR043607|interpro:IPR044341|interpro:IPR044370|interpro:IPR044873|interpro:IPR044874|rcsb pdb:1Q4Z|rcsb pdb:1T7G|rcsb pdb:1U4K|rcsb pdb:1WNC|rcsb pdb:1WYY|rcsb pdb:1XJP|rcsb pdb:1ZV7|rcsb pdb:1ZV8|rcsb pdb:1ZVB|rcsb pdb:2AJF|rcsb pdb:2BEQ|rcsb pdb:2BEZ|rcsb pdb:2DD8|rcsb pdb:2FXP|rcsb pdb:2GHV|rcsb pdb:2GHW|rcsb pdb:2RUM|rcsb pdb:2RUN|rcsb pdb:2RUO|rcsb pdb:3BGF|rcsb pdb:3D0G|rcsb pdb:3D0H|rcsb pdb:3D0I|rcsb pdb:3SCI|rcsb pdb:3SCJ|rcsb pdb:3SCK|rcsb pdb:3SCL|rcsb pdb:5WRG|rcsb pdb:5X4S|rcsb pdb:5X58|rcsb pdb:5X5B|rcsb pdb:5XJK|rcsb pdb:5XLR|rcsb pdb:5ZVM|rcsb pdb:6ACC|rcsb pdb:6ACD|rcsb pdb:6ACG|rcsb pdb:6ACK|rcsb pdb:6CRV|rcsb pdb:6CRW|rcsb pdb:6CRX|rcsb pdb:6CRZ|rcsb pdb:6CS0|rcsb pdb:6CS1|rcsb pdb:6CS2|rcsb pdb:6M3W|rcsb pdb:6NB6|rcsb pdb:6NB7|rcsb pdb:6VW1|rcsb pdb:6WAQ|rcsb pdb:7JN5|rcsb pdb:6ACJ|dip:DIP-29105N|reactome:R-HSA-9679509|reactome:R-HSA-9683686|reactome:R-HSA-9683701|refseq:NP_828851.1|reactome:R-HSA-9678110 go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR032500|interpro:IPR036326|interpro:IPR042578|interpro:IPR043002|interpro:IPR043473|interpro:IPR043607|interpro:IPR044341|interpro:IPR044370|interpro:IPR044873|interpro:IPR044874|rcsb pdb:1Q4Z|rcsb pdb:1T7G|rcsb pdb:1U4K|rcsb pdb:1WNC|rcsb pdb:1WYY|rcsb pdb:1XJP|rcsb pdb:1ZV7|rcsb pdb:1ZV8|rcsb pdb:1ZVB|rcsb pdb:2AJF|rcsb pdb:2BEQ|rcsb pdb:2BEZ|rcsb pdb:2DD8|rcsb pdb:2FXP|rcsb pdb:2GHV|rcsb pdb:2GHW|rcsb pdb:2RUM|rcsb pdb:2RUN|rcsb pdb:2RUO|rcsb pdb:3BGF|rcsb pdb:3D0G|rcsb pdb:3D0H|rcsb pdb:3D0I|rcsb pdb:3SCI|rcsb pdb:3SCJ|rcsb pdb:3SCK|rcsb pdb:3SCL|rcsb pdb:5WRG|rcsb pdb:5X4S|rcsb pdb:5X58|rcsb pdb:5X5B|rcsb pdb:5XJK|rcsb pdb:5XLR|rcsb pdb:5ZVM|rcsb pdb:6ACC|rcsb pdb:6ACD|rcsb pdb:6ACG|rcsb pdb:6ACK|rcsb pdb:6CRV|rcsb pdb:6CRW|rcsb pdb:6CRX|rcsb pdb:6CRZ|rcsb pdb:6CS0|rcsb pdb:6CS1|rcsb pdb:6CS2|rcsb pdb:6M3W|rcsb pdb:6NB6|rcsb pdb:6NB7|rcsb pdb:6VW1|rcsb pdb:6WAQ|rcsb pdb:7JN5|rcsb pdb:6ACJ|dip:DIP-29105N|reactome:R-HSA-9679509|reactome:R-HSA-9683686|reactome:R-HSA-9683701|refseq:NP_828851.1|reactome:R-HSA-9678110 - - - figure legend:Supplementary tables 1-4|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/07/09 2020/07/23 rogid:H4uZUhfNNQNcF4O+7CmC50IoAi8694009 rogid:H4uZUhfNNQNcF4O+7CmC50IoAi8694009 rigid:229l+RXp8RYZFbEn5VMlsZ51FNE false sufficient binding region:1-1190|his tag:c-c|strep ii tag:c-c|tag:c-c|tag:c-c|mutation:968-969 sufficient binding region:1-1190|his tag:c-c|strep ii tag:c-c|tag:c-c|tag:c-c|mutation:968-969 3 0 psi-mi:"MI:2287"(identification by structure determination) psi-mi:"MI:2287"(identification by structure determination) uniprotkb:P59594 uniprotkb:P59594 intact:EBI-15582614|intact:EBI-16063777|uniprotkb:Q6QU82|uniprotkb:Q7T696|uniprotkb:Q7TA19|uniprotkb:Q7TFA2|uniprotkb:Q7TFB1|uniprotkb:Q80BV6 intact:EBI-15582614|intact:EBI-16063777|uniprotkb:Q6QU82|uniprotkb:Q7T696|uniprotkb:Q7TA19|uniprotkb:Q7TFA2|uniprotkb:Q7TFB1|uniprotkb:Q80BV6 psi-mi:spike_sars(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name) psi-mi:spike_sars(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name) psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction) Kirchdoerfer et al. (2018) pubmed:30356097|imex:IM-28205 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-25761562|imex:IM-28205-3|wwpdb:6CRX|emdb:7575|emdb:7574|wwpdb:6CRW|wwpdb:6cs0|emdb:7578|wwpdb:6cs1|emdb:7579|wwpdb:6CRZ|emdb:7577 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR032500|interpro:IPR036326|interpro:IPR042578|interpro:IPR043002|interpro:IPR043473|interpro:IPR043607|interpro:IPR044341|interpro:IPR044370|interpro:IPR044873|interpro:IPR044874|rcsb pdb:1Q4Z|rcsb pdb:1T7G|rcsb pdb:1U4K|rcsb pdb:1WNC|rcsb pdb:1WYY|rcsb pdb:1XJP|rcsb pdb:1ZV7|rcsb pdb:1ZV8|rcsb pdb:1ZVB|rcsb pdb:2AJF|rcsb pdb:2BEQ|rcsb pdb:2BEZ|rcsb pdb:2DD8|rcsb pdb:2FXP|rcsb pdb:2GHV|rcsb pdb:2GHW|rcsb pdb:2RUM|rcsb pdb:2RUN|rcsb pdb:2RUO|rcsb pdb:3BGF|rcsb pdb:3D0G|rcsb pdb:3D0H|rcsb pdb:3D0I|rcsb pdb:3SCI|rcsb pdb:3SCJ|rcsb pdb:3SCK|rcsb pdb:3SCL|rcsb pdb:5WRG|rcsb pdb:5X4S|rcsb pdb:5X58|rcsb pdb:5X5B|rcsb pdb:5XJK|rcsb pdb:5XLR|rcsb pdb:5ZVM|rcsb pdb:6ACC|rcsb pdb:6ACD|rcsb pdb:6ACG|rcsb pdb:6ACK|rcsb pdb:6CRV|rcsb pdb:6CRW|rcsb pdb:6CRX|rcsb pdb:6CRZ|rcsb pdb:6CS0|rcsb pdb:6CS1|rcsb pdb:6CS2|rcsb pdb:6M3W|rcsb pdb:6NB6|rcsb pdb:6NB7|rcsb pdb:6VW1|rcsb pdb:6WAQ|rcsb pdb:7JN5|rcsb pdb:6ACJ|dip:DIP-29105N|reactome:R-HSA-9679509|reactome:R-HSA-9683686|reactome:R-HSA-9683701|refseq:NP_828851.1|reactome:R-HSA-9678110 go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR032500|interpro:IPR036326|interpro:IPR042578|interpro:IPR043002|interpro:IPR043473|interpro:IPR043607|interpro:IPR044341|interpro:IPR044370|interpro:IPR044873|interpro:IPR044874|rcsb pdb:1Q4Z|rcsb pdb:1T7G|rcsb pdb:1U4K|rcsb pdb:1WNC|rcsb pdb:1WYY|rcsb pdb:1XJP|rcsb pdb:1ZV7|rcsb pdb:1ZV8|rcsb pdb:1ZVB|rcsb pdb:2AJF|rcsb pdb:2BEQ|rcsb pdb:2BEZ|rcsb pdb:2DD8|rcsb pdb:2FXP|rcsb pdb:2GHV|rcsb pdb:2GHW|rcsb pdb:2RUM|rcsb pdb:2RUN|rcsb pdb:2RUO|rcsb pdb:3BGF|rcsb pdb:3D0G|rcsb pdb:3D0H|rcsb pdb:3D0I|rcsb pdb:3SCI|rcsb pdb:3SCJ|rcsb pdb:3SCK|rcsb pdb:3SCL|rcsb pdb:5WRG|rcsb pdb:5X4S|rcsb pdb:5X58|rcsb pdb:5X5B|rcsb pdb:5XJK|rcsb pdb:5XLR|rcsb pdb:5ZVM|rcsb pdb:6ACC|rcsb pdb:6ACD|rcsb pdb:6ACG|rcsb pdb:6ACK|rcsb pdb:6CRV|rcsb pdb:6CRW|rcsb pdb:6CRX|rcsb pdb:6CRZ|rcsb pdb:6CS0|rcsb pdb:6CS1|rcsb pdb:6CS2|rcsb pdb:6M3W|rcsb pdb:6NB6|rcsb pdb:6NB7|rcsb pdb:6VW1|rcsb pdb:6WAQ|rcsb pdb:7JN5|rcsb pdb:6ACJ|dip:DIP-29105N|reactome:R-HSA-9679509|reactome:R-HSA-9683686|reactome:R-HSA-9683701|refseq:NP_828851.1|reactome:R-HSA-9678110 - - - figure legend:Supplementary tables 1-4|publication year:"For PDBe entry 6cs0 the mutations have been omitted on the \"Visualisation\" but are still there in the sequence."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/07/09 2020/07/23 rogid:H4uZUhfNNQNcF4O+7CmC50IoAi8694009 rogid:H4uZUhfNNQNcF4O+7CmC50IoAi8694009 rigid:229l+RXp8RYZFbEn5VMlsZ51FNE false sufficient binding region:1-1190|tag:c-c|tag:c-c|mutation:968-969 sufficient binding region:1-1190|tag:c-c|tag:c-c|mutation:968-969 3 0 psi-mi:"MI:2287"(identification by structure determination) psi-mi:"MI:2287"(identification by structure determination) uniprotkb:Q9BYF1 uniprotkb:P59594 intact:EBI-7730807|ensembl:ENSP00000252519|ensembl:ENSP00000389326|ensembl:ENSP00000504103|ensembl:ENSP00000505992|intact:EBI-25767352|uniprotkb:Q9UFZ6|uniprotkb:Q9NRA7|intact:MINT-4538816|uniprotkb:C7ECU1|uniprotkb:Q6UWP0|uniprotkb:Q86WT0|uniprotkb:A0A7D6JAD5|intact:EBI-15814450 intact:EBI-15582614|intact:EBI-16063777|uniprotkb:Q6QU82|uniprotkb:Q7T696|uniprotkb:Q7TA19|uniprotkb:Q7TFA2|uniprotkb:Q7TFB1|uniprotkb:Q80BV6 psi-mi:ace2_human(display_long)|uniprotkb:ACE2(gene name)|psi-mi:ACE2(display_short)|uniprotkb:UNQ868/PRO1885(orf name)|uniprotkb:Angiotensin-converting enzyme homolog(gene name synonym)|uniprotkb:Metalloprotease MPROT15(gene name synonym)|uniprotkb:Angiotensin-converting enzyme-related carboxypeptidase(gene name synonym) psi-mi:spike_sars(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name) psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction) Kirchdoerfer et al. (2018) pubmed:30356097|imex:IM-28205 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25761614|imex:IM-28205-5|wwpdb:6cs2|emdb:7582 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000252519(transcript)|ensembl:ENST00000427411(transcript)|ensembl:ENST00000678073(transcript)|ensembl:ENST00000680121(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0003051"(angiotensin-mediated drinking behavior)|go:"GO:0003081"(regulation of systemic arterial blood pressure by renin-angiotensin)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004180"(carboxypeptidase activity)|go:"GO:0004181"(metallocarboxypeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006508"(proteolysis)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008241"(peptidyl-dipeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0015827"(tryptophan transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|ensembl:ENSG00000130234(gene)|go:"GO:0051957"(positive regulation of amino acid transport)|go:"GO:0060452"(positive regulation of cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1905737"(positive regulation of L-proline import across plasma membrane)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR001548(Peptidase M2, peptidyl-dipeptidase A)|interpro:IPR031588|mint:Q9BYF1|rcsb pdb:1R42|rcsb pdb:1R4L|rcsb pdb:1XJP|rcsb pdb:2AJF|rcsb pdb:3D0G|rcsb pdb:3D0H|rcsb pdb:3D0I|rcsb pdb:3KBH|rcsb pdb:3SCI|rcsb pdb:3SCJ|rcsb pdb:3SCK|rcsb pdb:3SCL|rcsb pdb:6ACG|rcsb pdb:6ACJ|rcsb pdb:6ACK|rcsb pdb:6CS2|rcsb pdb:6LZG|rcsb pdb:6M0J|rcsb pdb:6M17|rcsb pdb:6M18|go:"GO:0050727"(regulation of inflammatory response)|rcsb pdb:6M1D|rcsb pdb:6VW1|rcsb pdb:7A91|rcsb pdb:7A92|rcsb pdb:7A94|rcsb pdb:7A95|rcsb pdb:7A96|rcsb pdb:7A97|rcsb pdb:7A98|rcsb pdb:7BH9|rcsb pdb:7CT5|rcsb pdb:7DDO|rcsb pdb:7DDP|rcsb pdb:7DF4|rcsb pdb:7DMU|rcsb pdb:7DWX|rcsb pdb:7DX4|rcsb pdb:7DX5|rcsb pdb:7DX6|rcsb pdb:7DX7|rcsb pdb:7DX8|rcsb pdb:7DX9|rcsb pdb:7JVO|rcsb pdb:7KJ2|rcsb pdb:7KJ3|rcsb pdb:7KJ4|rcsb pdb:7KMB|rcsb pdb:7KMS|rcsb pdb:7KMZ|rcsb pdb:7KNB|rcsb pdb:7KNE|rcsb pdb:7KNH|rcsb pdb:7L0N|rcsb pdb:7L7F|rcsb pdb:7LO4|rcsb pdb:7MJM|rcsb pdb:7MJN|rcsb pdb:7NXC|reactome:R-HSA-2022377|reactome:R-HSA-9678110|reactome:R-HSA-9679191|reactome:R-HSA-9694614|rcsb pdb:7KNI|dip:DIP-44689N|refseq:NP_068576.1 go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR032500|interpro:IPR036326|interpro:IPR042578|interpro:IPR043002|interpro:IPR043473|interpro:IPR043607|interpro:IPR044341|interpro:IPR044370|interpro:IPR044873|interpro:IPR044874|rcsb pdb:1Q4Z|rcsb pdb:1T7G|rcsb pdb:1U4K|rcsb pdb:1WNC|rcsb pdb:1WYY|rcsb pdb:1XJP|rcsb pdb:1ZV7|rcsb pdb:1ZV8|rcsb pdb:1ZVB|rcsb pdb:2AJF|rcsb pdb:2BEQ|rcsb pdb:2BEZ|rcsb pdb:2DD8|rcsb pdb:2FXP|rcsb pdb:2GHV|rcsb pdb:2GHW|rcsb pdb:2RUM|rcsb pdb:2RUN|rcsb pdb:2RUO|rcsb pdb:3BGF|rcsb pdb:3D0G|rcsb pdb:3D0H|rcsb pdb:3D0I|rcsb pdb:3SCI|rcsb pdb:3SCJ|rcsb pdb:3SCK|rcsb pdb:3SCL|rcsb pdb:5WRG|rcsb pdb:5X4S|rcsb pdb:5X58|rcsb pdb:5X5B|rcsb pdb:5XJK|rcsb pdb:5XLR|rcsb pdb:5ZVM|rcsb pdb:6ACC|rcsb pdb:6ACD|rcsb pdb:6ACG|rcsb pdb:6ACK|rcsb pdb:6CRV|rcsb pdb:6CRW|rcsb pdb:6CRX|rcsb pdb:6CRZ|rcsb pdb:6CS0|rcsb pdb:6CS1|rcsb pdb:6CS2|rcsb pdb:6M3W|rcsb pdb:6NB6|rcsb pdb:6NB7|rcsb pdb:6VW1|rcsb pdb:6WAQ|rcsb pdb:7JN5|rcsb pdb:6ACJ|dip:DIP-29105N|reactome:R-HSA-9679509|reactome:R-HSA-9683686|reactome:R-HSA-9683701|refseq:NP_828851.1|reactome:R-HSA-9678110 - comment:mint|function:Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses - figure legend:Supplementary tables 1-4|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/07/09 2020/07/23 rogid:ZxuR6gzxz4Ns+hYH5uksGdn8S7o9606 rogid:H4uZUhfNNQNcF4O+7CmC50IoAi8694009 rigid:RfmpiMBj3JxEzdNSOZb1l0E86N0 false sufficient binding region:1-615|tag:c-c sufficient binding region:1-1190|tag:c-c|tag:c-c|mutation:968-969 1 3 psi-mi:"MI:2287"(identification by structure determination) psi-mi:"MI:2287"(identification by structure determination) uniprotkb:Q9BYF1 uniprotkb:P59594 intact:EBI-7730807|ensembl:ENSP00000252519|ensembl:ENSP00000389326|ensembl:ENSP00000504103|ensembl:ENSP00000505992|intact:EBI-25767352|uniprotkb:Q9UFZ6|uniprotkb:Q9NRA7|intact:MINT-4538816|uniprotkb:C7ECU1|uniprotkb:Q6UWP0|uniprotkb:Q86WT0|uniprotkb:A0A7D6JAD5|intact:EBI-15814450 intact:EBI-15582614|intact:EBI-16063777|uniprotkb:Q6QU82|uniprotkb:Q7T696|uniprotkb:Q7TA19|uniprotkb:Q7TFA2|uniprotkb:Q7TFB1|uniprotkb:Q80BV6 psi-mi:ace2_human(display_long)|uniprotkb:ACE2(gene name)|psi-mi:ACE2(display_short)|uniprotkb:UNQ868/PRO1885(orf name)|uniprotkb:Angiotensin-converting enzyme homolog(gene name synonym)|uniprotkb:Metalloprotease MPROT15(gene name synonym)|uniprotkb:Angiotensin-converting enzyme-related carboxypeptidase(gene name synonym) psi-mi:spike_sars(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name) psi-mi:"MI:0107"(surface plasmon resonance) Kirchdoerfer et al. (2018) pubmed:30356097|imex:IM-28205 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-25761687|imex:IM-28205-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000252519(transcript)|ensembl:ENST00000427411(transcript)|ensembl:ENST00000678073(transcript)|ensembl:ENST00000680121(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0003051"(angiotensin-mediated drinking behavior)|go:"GO:0003081"(regulation of systemic arterial blood pressure by renin-angiotensin)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004180"(carboxypeptidase activity)|go:"GO:0004181"(metallocarboxypeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006508"(proteolysis)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008241"(peptidyl-dipeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0015827"(tryptophan transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|ensembl:ENSG00000130234(gene)|go:"GO:0051957"(positive regulation of amino acid transport)|go:"GO:0060452"(positive regulation of cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1905737"(positive regulation of L-proline import across plasma membrane)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR001548(Peptidase M2, peptidyl-dipeptidase A)|interpro:IPR031588|mint:Q9BYF1|rcsb pdb:1R42|rcsb pdb:1R4L|rcsb pdb:1XJP|rcsb pdb:2AJF|rcsb pdb:3D0G|rcsb pdb:3D0H|rcsb pdb:3D0I|rcsb pdb:3KBH|rcsb pdb:3SCI|rcsb pdb:3SCJ|rcsb pdb:3SCK|rcsb pdb:3SCL|rcsb pdb:6ACG|rcsb pdb:6ACJ|rcsb pdb:6ACK|rcsb pdb:6CS2|rcsb pdb:6LZG|rcsb pdb:6M0J|rcsb pdb:6M17|rcsb pdb:6M18|go:"GO:0050727"(regulation of inflammatory response)|rcsb pdb:6M1D|rcsb pdb:6VW1|rcsb pdb:7A91|rcsb pdb:7A92|rcsb pdb:7A94|rcsb pdb:7A95|rcsb pdb:7A96|rcsb pdb:7A97|rcsb pdb:7A98|rcsb pdb:7BH9|rcsb pdb:7CT5|rcsb pdb:7DDO|rcsb pdb:7DDP|rcsb pdb:7DF4|rcsb pdb:7DMU|rcsb pdb:7DWX|rcsb pdb:7DX4|rcsb pdb:7DX5|rcsb pdb:7DX6|rcsb pdb:7DX7|rcsb pdb:7DX8|rcsb pdb:7DX9|rcsb pdb:7JVO|rcsb pdb:7KJ2|rcsb pdb:7KJ3|rcsb pdb:7KJ4|rcsb pdb:7KMB|rcsb pdb:7KMS|rcsb pdb:7KMZ|rcsb pdb:7KNB|rcsb pdb:7KNE|rcsb pdb:7KNH|rcsb pdb:7L0N|rcsb pdb:7L7F|rcsb pdb:7LO4|rcsb pdb:7MJM|rcsb pdb:7MJN|rcsb pdb:7NXC|reactome:R-HSA-2022377|reactome:R-HSA-9678110|reactome:R-HSA-9679191|reactome:R-HSA-9694614|rcsb pdb:7KNI|dip:DIP-44689N|refseq:NP_068576.1 go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR032500|interpro:IPR036326|interpro:IPR042578|interpro:IPR043002|interpro:IPR043473|interpro:IPR043607|interpro:IPR044341|interpro:IPR044370|interpro:IPR044873|interpro:IPR044874|rcsb pdb:1Q4Z|rcsb pdb:1T7G|rcsb pdb:1U4K|rcsb pdb:1WNC|rcsb pdb:1WYY|rcsb pdb:1XJP|rcsb pdb:1ZV7|rcsb pdb:1ZV8|rcsb pdb:1ZVB|rcsb pdb:2AJF|rcsb pdb:2BEQ|rcsb pdb:2BEZ|rcsb pdb:2DD8|rcsb pdb:2FXP|rcsb pdb:2GHV|rcsb pdb:2GHW|rcsb pdb:2RUM|rcsb pdb:2RUN|rcsb pdb:2RUO|rcsb pdb:3BGF|rcsb pdb:3D0G|rcsb pdb:3D0H|rcsb pdb:3D0I|rcsb pdb:3SCI|rcsb pdb:3SCJ|rcsb pdb:3SCK|rcsb pdb:3SCL|rcsb pdb:5WRG|rcsb pdb:5X4S|rcsb pdb:5X58|rcsb pdb:5X5B|rcsb pdb:5XJK|rcsb pdb:5XLR|rcsb pdb:5ZVM|rcsb pdb:6ACC|rcsb pdb:6ACD|rcsb pdb:6ACG|rcsb pdb:6ACK|rcsb pdb:6CRV|rcsb pdb:6CRW|rcsb pdb:6CRX|rcsb pdb:6CRZ|rcsb pdb:6CS0|rcsb pdb:6CS1|rcsb pdb:6CS2|rcsb pdb:6M3W|rcsb pdb:6NB6|rcsb pdb:6NB7|rcsb pdb:6VW1|rcsb pdb:6WAQ|rcsb pdb:7JN5|rcsb pdb:6ACJ|dip:DIP-29105N|reactome:R-HSA-9679509|reactome:R-HSA-9683686|reactome:R-HSA-9683701|refseq:NP_828851.1|reactome:R-HSA-9678110 - comment:mint|function:Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses - figure legend:Supplementary figure 7|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:185.0x10^-9(molar) 2020/07/09 2020/07/23 rogid:ZxuR6gzxz4Ns+hYH5uksGdn8S7o9606 rogid:H4uZUhfNNQNcF4O+7CmC50IoAi8694009 rigid:RfmpiMBj3JxEzdNSOZb1l0E86N0 false sufficient binding region:1-615|tag:c-c strep ii tag:c-c|sufficient binding region:1-1190|tag:c-c|tag:c-c|mutation with no effect:968-969|his tag:c-c - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P59594 uniprotkb:P59594 intact:EBI-15582614|intact:EBI-16063777|uniprotkb:Q6QU82|uniprotkb:Q7T696|uniprotkb:Q7TA19|uniprotkb:Q7TFA2|uniprotkb:Q7TFB1|uniprotkb:Q80BV6 intact:EBI-15582614|intact:EBI-16063777|uniprotkb:Q6QU82|uniprotkb:Q7T696|uniprotkb:Q7TA19|uniprotkb:Q7TFA2|uniprotkb:Q7TFB1|uniprotkb:Q80BV6 psi-mi:spike_sars(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name) psi-mi:spike_sars(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name) psi-mi:"MI:0071"(molecular sieving) Kirchdoerfer et al. (2018) pubmed:30356097|imex:IM-28205 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-25761756|imex:IM-28205-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR032500|interpro:IPR036326|interpro:IPR042578|interpro:IPR043002|interpro:IPR043473|interpro:IPR043607|interpro:IPR044341|interpro:IPR044370|interpro:IPR044873|interpro:IPR044874|rcsb pdb:1Q4Z|rcsb pdb:1T7G|rcsb pdb:1U4K|rcsb pdb:1WNC|rcsb pdb:1WYY|rcsb pdb:1XJP|rcsb pdb:1ZV7|rcsb pdb:1ZV8|rcsb pdb:1ZVB|rcsb pdb:2AJF|rcsb pdb:2BEQ|rcsb pdb:2BEZ|rcsb pdb:2DD8|rcsb pdb:2FXP|rcsb pdb:2GHV|rcsb pdb:2GHW|rcsb pdb:2RUM|rcsb pdb:2RUN|rcsb pdb:2RUO|rcsb pdb:3BGF|rcsb pdb:3D0G|rcsb pdb:3D0H|rcsb pdb:3D0I|rcsb pdb:3SCI|rcsb pdb:3SCJ|rcsb pdb:3SCK|rcsb pdb:3SCL|rcsb pdb:5WRG|rcsb pdb:5X4S|rcsb pdb:5X58|rcsb pdb:5X5B|rcsb pdb:5XJK|rcsb pdb:5XLR|rcsb pdb:5ZVM|rcsb pdb:6ACC|rcsb pdb:6ACD|rcsb pdb:6ACG|rcsb pdb:6ACK|rcsb pdb:6CRV|rcsb pdb:6CRW|rcsb pdb:6CRX|rcsb pdb:6CRZ|rcsb pdb:6CS0|rcsb pdb:6CS1|rcsb pdb:6CS2|rcsb pdb:6M3W|rcsb pdb:6NB6|rcsb pdb:6NB7|rcsb pdb:6VW1|rcsb pdb:6WAQ|rcsb pdb:7JN5|rcsb pdb:6ACJ|dip:DIP-29105N|reactome:R-HSA-9679509|reactome:R-HSA-9683686|reactome:R-HSA-9683701|refseq:NP_828851.1|reactome:R-HSA-9678110 go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR032500|interpro:IPR036326|interpro:IPR042578|interpro:IPR043002|interpro:IPR043473|interpro:IPR043607|interpro:IPR044341|interpro:IPR044370|interpro:IPR044873|interpro:IPR044874|rcsb pdb:1Q4Z|rcsb pdb:1T7G|rcsb pdb:1U4K|rcsb pdb:1WNC|rcsb pdb:1WYY|rcsb pdb:1XJP|rcsb pdb:1ZV7|rcsb pdb:1ZV8|rcsb pdb:1ZVB|rcsb pdb:2AJF|rcsb pdb:2BEQ|rcsb pdb:2BEZ|rcsb pdb:2DD8|rcsb pdb:2FXP|rcsb pdb:2GHV|rcsb pdb:2GHW|rcsb pdb:2RUM|rcsb pdb:2RUN|rcsb pdb:2RUO|rcsb pdb:3BGF|rcsb pdb:3D0G|rcsb pdb:3D0H|rcsb pdb:3D0I|rcsb pdb:3SCI|rcsb pdb:3SCJ|rcsb pdb:3SCK|rcsb pdb:3SCL|rcsb pdb:5WRG|rcsb pdb:5X4S|rcsb pdb:5X58|rcsb pdb:5X5B|rcsb pdb:5XJK|rcsb pdb:5XLR|rcsb pdb:5ZVM|rcsb pdb:6ACC|rcsb pdb:6ACD|rcsb pdb:6ACG|rcsb pdb:6ACK|rcsb pdb:6CRV|rcsb pdb:6CRW|rcsb pdb:6CRX|rcsb pdb:6CRZ|rcsb pdb:6CS0|rcsb pdb:6CS1|rcsb pdb:6CS2|rcsb pdb:6M3W|rcsb pdb:6NB6|rcsb pdb:6NB7|rcsb pdb:6VW1|rcsb pdb:6WAQ|rcsb pdb:7JN5|rcsb pdb:6ACJ|dip:DIP-29105N|reactome:R-HSA-9679509|reactome:R-HSA-9683686|reactome:R-HSA-9683701|refseq:NP_828851.1|reactome:R-HSA-9678110 - - - figure legend:Supplementary figure 1|comment:It is not stated if the C terminal His and Strep ii tags have been cleaved or not.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/07/09 2020/07/23 rogid:H4uZUhfNNQNcF4O+7CmC50IoAi8694009 rogid:H4uZUhfNNQNcF4O+7CmC50IoAi8694009 rigid:++yTbdZqrbOiV5BEW5iM+/qQegk false sufficient binding region:1-1190|his tag:c-c|strep ii tag:c-c|tag:c-c|tag:c-c|mutation:968-969 sufficient binding region:1-1190|his tag:c-c|strep ii tag:c-c|tag:c-c|tag:c-c|mutation:968-969 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BYF1 uniprotkb:P59594 intact:EBI-7730807|ensembl:ENSP00000252519|ensembl:ENSP00000389326|ensembl:ENSP00000504103|ensembl:ENSP00000505992|intact:EBI-25767352|uniprotkb:Q9UFZ6|uniprotkb:Q9NRA7|intact:MINT-4538816|uniprotkb:C7ECU1|uniprotkb:Q6UWP0|uniprotkb:Q86WT0|uniprotkb:A0A7D6JAD5|intact:EBI-15814450 intact:EBI-15582614|intact:EBI-16063777|uniprotkb:Q6QU82|uniprotkb:Q7T696|uniprotkb:Q7TA19|uniprotkb:Q7TFA2|uniprotkb:Q7TFB1|uniprotkb:Q80BV6 psi-mi:ace2_human(display_long)|uniprotkb:ACE2(gene name)|psi-mi:ACE2(display_short)|uniprotkb:UNQ868/PRO1885(orf name)|uniprotkb:Angiotensin-converting enzyme homolog(gene name synonym)|uniprotkb:Metalloprotease MPROT15(gene name synonym)|uniprotkb:Angiotensin-converting enzyme-related carboxypeptidase(gene name synonym) psi-mi:spike_sars(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name) psi-mi:"MI:0071"(molecular sieving) Kirchdoerfer et al. (2018) pubmed:30356097|imex:IM-28205 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-25761739|imex:IM-28205-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000252519(transcript)|ensembl:ENST00000427411(transcript)|ensembl:ENST00000678073(transcript)|ensembl:ENST00000680121(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0003051"(angiotensin-mediated drinking behavior)|go:"GO:0003081"(regulation of systemic arterial blood pressure by renin-angiotensin)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004180"(carboxypeptidase activity)|go:"GO:0004181"(metallocarboxypeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006508"(proteolysis)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008241"(peptidyl-dipeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0015827"(tryptophan transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|ensembl:ENSG00000130234(gene)|go:"GO:0051957"(positive regulation of amino acid transport)|go:"GO:0060452"(positive regulation of cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1905737"(positive regulation of L-proline import across plasma membrane)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR001548(Peptidase M2, peptidyl-dipeptidase A)|interpro:IPR031588|mint:Q9BYF1|rcsb pdb:1R42|rcsb pdb:1R4L|rcsb pdb:1XJP|rcsb pdb:2AJF|rcsb pdb:3D0G|rcsb pdb:3D0H|rcsb pdb:3D0I|rcsb pdb:3KBH|rcsb pdb:3SCI|rcsb pdb:3SCJ|rcsb pdb:3SCK|rcsb pdb:3SCL|rcsb pdb:6ACG|rcsb pdb:6ACJ|rcsb pdb:6ACK|rcsb pdb:6CS2|rcsb pdb:6LZG|rcsb pdb:6M0J|rcsb pdb:6M17|rcsb pdb:6M18|go:"GO:0050727"(regulation of inflammatory response)|rcsb pdb:6M1D|rcsb pdb:6VW1|rcsb pdb:7A91|rcsb pdb:7A92|rcsb pdb:7A94|rcsb pdb:7A95|rcsb pdb:7A96|rcsb pdb:7A97|rcsb pdb:7A98|rcsb pdb:7BH9|rcsb pdb:7CT5|rcsb pdb:7DDO|rcsb pdb:7DDP|rcsb pdb:7DF4|rcsb pdb:7DMU|rcsb pdb:7DWX|rcsb pdb:7DX4|rcsb pdb:7DX5|rcsb pdb:7DX6|rcsb pdb:7DX7|rcsb pdb:7DX8|rcsb pdb:7DX9|rcsb pdb:7JVO|rcsb pdb:7KJ2|rcsb pdb:7KJ3|rcsb pdb:7KJ4|rcsb pdb:7KMB|rcsb pdb:7KMS|rcsb pdb:7KMZ|rcsb pdb:7KNB|rcsb pdb:7KNE|rcsb pdb:7KNH|rcsb pdb:7L0N|rcsb pdb:7L7F|rcsb pdb:7LO4|rcsb pdb:7MJM|rcsb pdb:7MJN|rcsb pdb:7NXC|reactome:R-HSA-2022377|reactome:R-HSA-9678110|reactome:R-HSA-9679191|reactome:R-HSA-9694614|rcsb pdb:7KNI|dip:DIP-44689N|refseq:NP_068576.1 go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR032500|interpro:IPR036326|interpro:IPR042578|interpro:IPR043002|interpro:IPR043473|interpro:IPR043607|interpro:IPR044341|interpro:IPR044370|interpro:IPR044873|interpro:IPR044874|rcsb pdb:1Q4Z|rcsb pdb:1T7G|rcsb pdb:1U4K|rcsb pdb:1WNC|rcsb pdb:1WYY|rcsb pdb:1XJP|rcsb pdb:1ZV7|rcsb pdb:1ZV8|rcsb pdb:1ZVB|rcsb pdb:2AJF|rcsb pdb:2BEQ|rcsb pdb:2BEZ|rcsb pdb:2DD8|rcsb pdb:2FXP|rcsb pdb:2GHV|rcsb pdb:2GHW|rcsb pdb:2RUM|rcsb pdb:2RUN|rcsb pdb:2RUO|rcsb pdb:3BGF|rcsb pdb:3D0G|rcsb pdb:3D0H|rcsb pdb:3D0I|rcsb pdb:3SCI|rcsb pdb:3SCJ|rcsb pdb:3SCK|rcsb pdb:3SCL|rcsb pdb:5WRG|rcsb pdb:5X4S|rcsb pdb:5X58|rcsb pdb:5X5B|rcsb pdb:5XJK|rcsb pdb:5XLR|rcsb pdb:5ZVM|rcsb pdb:6ACC|rcsb pdb:6ACD|rcsb pdb:6ACG|rcsb pdb:6ACK|rcsb pdb:6CRV|rcsb pdb:6CRW|rcsb pdb:6CRX|rcsb pdb:6CRZ|rcsb pdb:6CS0|rcsb pdb:6CS1|rcsb pdb:6CS2|rcsb pdb:6M3W|rcsb pdb:6NB6|rcsb pdb:6NB7|rcsb pdb:6VW1|rcsb pdb:6WAQ|rcsb pdb:7JN5|rcsb pdb:6ACJ|dip:DIP-29105N|reactome:R-HSA-9679509|reactome:R-HSA-9683686|reactome:R-HSA-9683701|refseq:NP_828851.1|reactome:R-HSA-9678110 - comment:mint|function:Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses - figure legend:Supplementary figure 1|comment:It is not stated if the Spike protein C terminal His and Strep ii tags have been cleaved or not.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/07/09 2020/07/23 rogid:ZxuR6gzxz4Ns+hYH5uksGdn8S7o9606 rogid:H4uZUhfNNQNcF4O+7CmC50IoAi8694009 rigid:RfmpiMBj3JxEzdNSOZb1l0E86N0 false sufficient binding region:1-615|tag:c-c sufficient binding region:1-1190|tag:c-c|tag:c-c|mutation:968-969 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)