#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:K9N7C7-PRO_0000422452	uniprotkb:K9N7C7-PRO_0000422452	intact:EBI-25592093	intact:EBI-25592093	psi-mi:k9n7c7-pro_0000422452(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:k9n7c7-pro_0000422452(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	Zhang et al. (2018)	pubmed:30135128|imex:IM-27938	taxid:1263720(cvemc)|taxid:1263720("Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1)")	taxid:1263720(cvemc)|taxid:1263720("Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25568763|wwpdb:5yvd|imex:IM-27938-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25591996(chain-parent)	intact:EBI-25591996(chain-parent)	-	chain-seq-start:6433|chain-seq-end:6775	chain-seq-start:6433|chain-seq-end:6775	figure legend:Table 1|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/04/22	2020/04/29	rogid:f9/fchviwfMOLsD+x0i7iUJJe2c1263720	rogid:f9/fchviwfMOLsD+x0i7iUJJe2c1263720	rigid:dbh15pKQ/Oz0bKb9Oz1MylSKP3g	false	his tag:n-n	his tag:n-n	6	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:K9N7C7-PRO_0000422452	uniprotkb:K9N7C7-PRO_0000422452	intact:EBI-25592093	intact:EBI-25592093	psi-mi:k9n7c7-pro_0000422452(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:k9n7c7-pro_0000422452(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0028"(cosedimentation in solution)	Zhang et al. (2018)	pubmed:30135128|imex:IM-27938	taxid:1263720(cvemc)|taxid:1263720("Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1)")	taxid:1263720(cvemc)|taxid:1263720("Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25568843|imex:IM-27938-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25591996(chain-parent)	intact:EBI-25591996(chain-parent)	-	chain-seq-start:6433|chain-seq-end:6775	chain-seq-start:6433|chain-seq-end:6775	figure legend:Fig. 6A|comment:"To validate the significance of the interfaces, analytical ultracentrifugation (AUC) analysis was conducted to assess the oligomeric forms of soluble and stable variants. Mutant D39A existed primarily as a hexamer, while mutant E263A was distributed equally between the monomer and hexamer states. By comparison, mutants N38A, Y58A, and N157A existed predominately as monomers (Fig. 6A)."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/04/22	2020/04/29	rogid:f9/fchviwfMOLsD+x0i7iUJJe2c1263720	rogid:f9/fchviwfMOLsD+x0i7iUJJe2c1263720	rigid:dbh15pKQ/Oz0bKb9Oz1MylSKP3g	false	his tag:n-n|mutation with no effect:39-39|mutation decreasing interaction strength:263-263|mutation disrupting interaction strength:38-38|mutation disrupting interaction strength:58-58|mutation disrupting interaction strength:157-157	his tag:n-n|mutation with no effect:39-39|mutation decreasing interaction strength:263-263|mutation disrupting interaction strength:38-38|mutation disrupting interaction strength:58-58|mutation disrupting interaction strength:157-157	6	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:K9N7C7-PRO_0000422446	uniprotkb:K9N7C7-PRO_0000422452	intact:EBI-25592080	intact:EBI-25592093	psi-mi:k9n7c7-pro_0000422446(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:k9n7c7-pro_0000422452(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhang et al. (2018)	pubmed:30135128|imex:IM-27938	taxid:1263720(cvemc)|taxid:1263720("Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1)")	taxid:1263720(cvemc)|taxid:1263720("Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25568872|imex:IM-27938-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25591996(chain-parent)	intact:EBI-25591996(chain-parent)	-	chain-seq-start:3929|chain-seq-end:4127	chain-seq-start:6433|chain-seq-end:6775	figure legend:Fig. 8A|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/04/22	2020/04/29	rogid:aNT0rd2MwJasTBwTfZfd4JvJXqA1263720	rogid:f9/fchviwfMOLsD+x0i7iUJJe2c1263720	rigid:/J1FNPY8cj5tgQRGL/ycatuG4Kg	false	his tag:?-?|glutathione s tranferase tag:?-?	flag tag:n-n|mutation with no effect:39-39|mutation with no effect:263-263|mutation with no effect:38-38|mutation with no effect:58-58|mutation with no effect:157-157	-	6	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:K9N7C7-PRO_0000422446	uniprotkb:K9N7C7-PRO_0000422452	intact:EBI-25592080	intact:EBI-25592093	psi-mi:k9n7c7-pro_0000422446(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:k9n7c7-pro_0000422452(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:1247"(microscale thermophoresis)	Zhang et al. (2018)	pubmed:30135128|imex:IM-27938	taxid:1263720(cvemc)|taxid:1263720("Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1)")	taxid:1263720(cvemc)|taxid:1263720("Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25569839|imex:IM-27938-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25591996(chain-parent)	intact:EBI-25591996(chain-parent)	-	chain-seq-start:3929|chain-seq-end:4127	chain-seq-start:6433|chain-seq-end:6775	figure legend:Fig. 8B|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:16.33x10^-6(molar)	2020/04/22	2020/04/29	rogid:aNT0rd2MwJasTBwTfZfd4JvJXqA1263720	rogid:f9/fchviwfMOLsD+x0i7iUJJe2c1263720	rigid:/J1FNPY8cj5tgQRGL/ycatuG4Kg	false	his tag:?-?|glutathione s tranferase tag:?-?	flag tag:n-n	-	6	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-27026255	uniprotkb:K9N7C7-PRO_0000422452	intact:EBI-25569321	intact:EBI-25592093	psi-mi:nsp7-nsp8_mers1-1(display_short)|psi-mi:EBI-27026255(display_long)|intact:MERS-CoV primase complex(complex recommended name)|intact:"2xNSP7:2xNSP8"(complex systematic name)	psi-mi:k9n7c7-pro_0000422452(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:1247"(microscale thermophoresis)	Zhang et al. (2018)	pubmed:30135128|imex:IM-27938	taxid:1263720(cvemc)|taxid:1263720("Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1)")	taxid:1263720(cvemc)|taxid:1263720("Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25569879|imex:IM-27938-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	complex portal:CPX-5746(complex-primary)|efo:"EFO:0007224"(see-also)|pubmed:22039154(see-also)|pubmed:30135128(see-also)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:1902680"(positive regulation of RNA biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|pubmed:32288963(see-also)|pubmed:16228002(see-also)|evidence ontology:"ECO:0005547"|pubmed:32015508(see-also)|pubmed:33658206(see-also)|pubmed:33999154(see-also)|pubmed:31987001(see-also)	intact:EBI-25591996(chain-parent)	-	curated-complex:Primase complex of the MERS coronavirus which binds dsRNA molecules and extends partially double-stranded RNA templates.|complex-assembly:Heterodimer   Heterotrimer   Heterotetramer|complex-properties:"Exists in potentially 3 different conformations: 1:1 heterodimers, heterotrimers of conformation 2xnsp7:1xnsp8 and 2:2 heterotetramers form by 2 heterodimers."|disease:"Coronavirus infectious disease [EFO:0007224]: results in infection in animals and humans, has material basis in coronaviruses, which are transmitted by droplet spread of respiratory secretions or transmitted by ingestion of contaminated food."	chain-seq-start:6433|chain-seq-end:6775	figure legend:Fig. 8C|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:6.48x10^-6(molar)	2020/04/22	2021/07/05	-	rogid:f9/fchviwfMOLsD+x0i7iUJJe2c1263720	-	false	his tag:?-?|glutathione s tranferase tag:?-?|his tag:?-?|his tag:?-?|glutathione s tranferase tag:?-?|his tag:?-?	flag tag:n-n	-	6	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)