#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q8IWT6 uniprotkb:Q8IWT6 intact:EBI-10970086|ensembl:ENSP00000259324|ensembl:ENSP00000361680|ensembl:ENSP00000361682|uniprotkb:Q9P2B1|uniprotkb:Q8NCI0|uniprotkb:Q6UXM2 intact:EBI-10970086|ensembl:ENSP00000259324|ensembl:ENSP00000361680|ensembl:ENSP00000361682|uniprotkb:Q9P2B1|uniprotkb:Q8NCI0|uniprotkb:Q6UXM2 psi-mi:lrc8a_human(display_long)|uniprotkb:LRRC8A(gene name)|psi-mi:LRRC8A(display_short)|uniprotkb:KIAA1437(gene name synonym)|uniprotkb:LRRC8(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 8A(gene name synonym)|uniprotkb:SWELL1(gene name synonym)|uniprotkb:Swelling protein 1(gene name synonym)|uniprotkb:UNQ221/PRO247(orf name) psi-mi:lrc8a_human(display_long)|uniprotkb:LRRC8A(gene name)|psi-mi:LRRC8A(display_short)|uniprotkb:KIAA1437(gene name synonym)|uniprotkb:LRRC8(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 8A(gene name synonym)|uniprotkb:SWELL1(gene name synonym)|uniprotkb:Swelling protein 1(gene name synonym)|uniprotkb:UNQ221/PRO247(orf name) psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction) Go et al. (2018) pubmed:30127360|imex:IM-28040 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-25633956|wwpdb:5ZSU|emdb:EMD-6952|imex:IM-28040-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001120716.1|refseq:NP_001120717.1|refseq:NP_062540.2|refseq:XP_005252152.1|refseq:XP_005252153.1|refseq:XP_006717249.1|refseq:XP_011517165.1|refseq:XP_011517166.1|refseq:XP_011517167.1|ensembl:ENSG00000136802(gene)|ensembl:ENST00000259324(transcript)|ensembl:ENST00000372599(transcript)|ensembl:ENST00000372600(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0002329"(pre-B cell differentiation)|go:"GO:0005225"(volume-sensitive anion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0015734"(taurine transport)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034702"(ion channel complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0098656"(anion transmembrane transport)|go:"GO:0140360"(cyclic-GMP-AMP transmembrane transporter activity)|go:"GO:0140361"(cyclic-GMP-AMP transmembrane import across plasma membrane)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR021040|interpro:IPR032675|mint:Q8IWT6|rcsb pdb:5ZSU|rcsb pdb:6DJB|reactome:R-HSA-5223345|dip:DIP-61360N refseq:NP_001120716.1|refseq:NP_001120717.1|refseq:NP_062540.2|refseq:XP_005252152.1|refseq:XP_005252153.1|refseq:XP_006717249.1|refseq:XP_011517165.1|refseq:XP_011517166.1|refseq:XP_011517167.1|ensembl:ENSG00000136802(gene)|ensembl:ENST00000259324(transcript)|ensembl:ENST00000372599(transcript)|ensembl:ENST00000372600(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0002329"(pre-B cell differentiation)|go:"GO:0005225"(volume-sensitive anion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0015734"(taurine transport)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034702"(ion channel complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0098656"(anion transmembrane transport)|go:"GO:0140360"(cyclic-GMP-AMP transmembrane transporter activity)|go:"GO:0140361"(cyclic-GMP-AMP transmembrane import across plasma membrane)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR021040|interpro:IPR032675|mint:Q8IWT6|rcsb pdb:5ZSU|rcsb pdb:6DJB|reactome:R-HSA-5223345|dip:DIP-61360N - - - figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/05/29 2020/05/29 rogid:4+VhpXqOjBfbrNagOqJ7eY/qy+s9606 rogid:4+VhpXqOjBfbrNagOqJ7eY/qy+s9606 rigid:vzcloR/O9xCAQLU7LXJwEDoCALo false - - 6 0 psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination) psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)