#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P01019	uniprotkb:P50052	intact:EBI-751728|uniprotkb:Q16358|uniprotkb:Q16359|uniprotkb:Q96F91|ensembl:ENSP00000355627	intact:EBI-1748067|uniprotkb:Q13016|uniprotkb:Q6FGY7|uniprotkb:B2R9V1|ensembl:ENSP00000360973|ensembl:ENSP00000505750	psi-mi:angt_human(display_long)|uniprotkb:Serpin A8(gene name synonym)|uniprotkb:AGT(gene name)|psi-mi:AGT(display_short)|uniprotkb:SERPINA8(gene name synonym)	psi-mi:agtr2_human(display_long)|uniprotkb:AGTR2(gene name)|psi-mi:AGTR2(display_short)|uniprotkb:Angiotensin II type-2 receptor(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Hidetsugu et al.	imex:IM-28051|pubmed:29967536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-25634028|wwpdb:5XJM|wwpdb:5XLI|imex:IM-28051-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000020.1|dip:DIP-309N|ensembl:ENSG00000135744(gene)|ensembl:ENST00000366667(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001819"(positive regulation of cytokine production)|rcsb pdb:2JP8|rcsb pdb:2WXW|rcsb pdb:2X0B|rcsb pdb:3CK0|rcsb pdb:3WOO|rcsb pdb:3WOR|rcsb pdb:4AA1|rcsb pdb:4APH|rcsb pdb:4FYS|rcsb pdb:5E2Q|rcsb pdb:5M3X|rcsb pdb:5M3Y|rcsb pdb:5XJM|rcsb pdb:6I3F|rcsb pdb:6I3I|rcsb pdb:6JOD|rcsb pdb:6OS0|rcsb pdb:7C6A|reactome:R-HSA-1989781|reactome:R-HSA-2022377|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-418594|go:"GO:0001822"(kidney development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002016"(regulation of blood volume by renin-angiotensin)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002019"(regulation of renal output by angiotensin)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002034"(maintenance of blood vessel diameter homeostasis by renin-angiotensin)|go:"GO:0003014"(renal system process)|go:"GO:0003051"(angiotensin-mediated drinking behavior)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007199"(G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048144"(fibroblast proliferation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048659"(smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051387"(negative regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051969"(regulation of transmission of nerve impulse)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070471"(uterine smooth muscle contraction)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072562"(blood microparticle)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:1901201"(regulation of extracellular matrix assembly)|go:"GO:1902632"(positive regulation of membrane hyperpolarization)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0008306"(associative learning)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0014873"(response to muscle activity involved in regulation of muscle adaptation)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031703"(type 2 angiotensin receptor binding)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034104"(negative regulation of tissue remodeling)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0035106"(operant conditioning)|go:"GO:0035813"(regulation of renal sodium excretion)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:1905010"(positive regulation of L-lysine import across plasma membrane)|go:"GO:1905589"(positive regulation of L-arginine import across plasma membrane)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR000227(Angiotensinogen)|interpro:IPR023795|interpro:IPR023796|interpro:IPR033834|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P01019|rcsb pdb:1N9U|rcsb pdb:1N9V	refseq:NP_000677.2|refseq:XP_011535835.1|ensembl:ENSG00000180772(gene)|ensembl:ENST00000371906(transcript)|ensembl:ENST00000681852(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0001991"(regulation of systemic arterial blood pressure by circulatory renin-angiotensin)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004945"(angiotensin type II receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007199"(G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010700"(negative regulation of norepinephrine secretion)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0032304"(negative regulation of icosanoid secretion)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0035932"(aldosterone secretion)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042311"(vasodilation)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0048019"(receptor antagonist activity)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051387"(negative regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0060993"(kidney morphogenesis)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000147(AT2 angiotensin II receptor)|interpro:IPR000248(Angiotensin II receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:5UNF|rcsb pdb:5UNG|rcsb pdb:5UNH|rcsb pdb:6JOD|reactome:R-HSA-375276|reactome:R-HSA-418594	-	-	-	figure legend:Fig 1, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/05/29	2020/06/05	rogid:tt2vGFrfLSJ+dIa11l402Vs/3S49606	rogid:tXWI4w7l3DHAfmhthRZY9Hxrvus9606	rigid:A12YLEM+7QkRnVdxAX2LzghVHZY	false	binding-associated region:35-40	binding-associated region:35-346	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)