#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q6UY14 uniprotkb:P28300 intact:EBI-742002|uniprotkb:Q5T5F7|uniprotkb:Q6IPM6|uniprotkb:Q8N643|uniprotkb:Q9HBS6|ensembl:ENSP00000271643|ensembl:ENSP00000358034|uniprotkb:B2RTT0|uniprotkb:F8WAD0 intact:EBI-3893481|uniprotkb:B2R5Q3|uniprotkb:Q5FWF0|ensembl:ENSP00000231004 psi-mi:atl4_human(display_long)|uniprotkb:Thrombospondin repeat-containing protein 1(gene name synonym)|uniprotkb:ADAMTSL4(gene name)|psi-mi:ADAMTSL4(display_short)|uniprotkb:TSRC1(gene name synonym)|uniprotkb:PP1396(orf name)|uniprotkb:UNQ2803/PRO34012(orf name) psi-mi:lyox_human(display_long)|uniprotkb:LOX(gene name)|psi-mi:LOX(display_short)|uniprotkb:Lysyl oxidase(gene name synonym) psi-mi:"MI:0018"(two hybrid) Aviram et al. (2019) pubmed:29758265|imex:IM-27643 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0917"(matrixdb) intact:EBI-25406960|imex:IM-27643-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061905.2|refseq:NP_079284.2|ensembl:ENSG00000143382(gene)|ensembl:ENST00000271643(transcript)|ensembl:ENST00000369038(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0002064"(epithelial cell development)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005614"(interstitial matrix)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006915"(apoptotic process)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR010294(ADAM-TS Spacer 1)|interpro:IPR010909(PLAC)|interpro:IPR036383|mint:Q6UY14|reactome:R-HSA-5083635|reactome:R-HSA-5173214|go:"GO:0005576"(extracellular region)|refseq:NP_001275536.1|refseq:NP_001275537.1|refseq:XP_011507950.1|refseq:XP_016856995.1 refseq:NP_002308.2|dip:DIP-49007N|ensembl:ENSG00000113083(gene)|ensembl:ENST00000231004(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004720"(protein-lysine 6-oxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0007507"(heart development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0018057"(peptidyl-lysine oxidation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030324"(lung development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035905"(ascending aorta development)|go:"GO:0035906"(descending aorta development)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0055001"(muscle cell development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061448"(connective tissue development)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:1900120"(regulation of receptor binding)|go:"GO:1903010"(regulation of bone development)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000586"(regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR001695(Lysyl oxidase)|interpro:IPR019828|mint:P28300|reactome:R-HSA-1566948|reactome:R-HSA-2243919|go:"GO:0046716"(muscle cell cellular homeostasis) - - - figure legend:Figure 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/01/15 2020/02/13 rogid:HIXY8OQopS51RVemJo0GTj8V0WQ9606 rogid:bDUlKQ5akDOhya4GydJ+PaLs7Fo9606 rigid:GU1psTzHVz8s9s8rUk23+dPtCxI false sufficient binding region:367-518|gal4 activation domain:?-? binding-associated region:24-417 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q7TSK7 uniprotkb:P28301 intact:EBI-25406979|ensembl:ENSMUSP00000088774|uniprotkb:Q3U0C8 intact:EBI-642911|ensembl:ENSMUSP00000025409|ensembl:ENSMUSP00000129247 psi-mi:atl2_mouse(display_long)|uniprotkb:TSP1-repeat-containing protein 1(gene name synonym)|uniprotkb:Adamtsl2(gene name)|psi-mi:Adamtsl2(display_short)|uniprotkb:Kiaa0605(gene name synonym)|uniprotkb:Tcp1(gene name synonym) psi-mi:lyox_mouse(display_long)|uniprotkb:Lysyl oxidase(gene name synonym)|uniprotkb:Ras excision protein(gene name synonym)|uniprotkb:Lox(gene name)|psi-mi:Lox(display_short)|uniprotkb:Rrg(gene name synonym) psi-mi:"MI:0813"(proximity ligation assay) Aviram et al. (2019) pubmed:29758265|imex:IM-27643 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0917"(matrixdb) intact:EBI-25407003|imex:IM-27643-21 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000036040(gene)|ensembl:ENSMUST00000091233(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0050436"(microfibril binding)|go:"GO:0060481"(lobar bronchus epithelium development)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR010294(ADAM-TS Spacer 1)|interpro:IPR010909(PLAC)|interpro:IPR013273(Peptidase M12B, ADAM-TS)|interpro:IPR036383|reactome:R-MMU-5173214|refseq:NP_084257.1 refseq:NP_001273110.1|refseq:NP_001273111.1|refseq:NP_034858.2|ensembl:ENSMUSG00000024529(gene)|ensembl:ENSMUST00000025409(transcript)|ensembl:ENSMUST00000171470(transcript)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035904"(aorta development)|go:"GO:0035905"(ascending aorta development)|go:"GO:0035906"(descending aorta development)|go:"GO:0042060"(wound healing)|go:"GO:0001568"(blood vessel development)|go:"GO:0042493"|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0055001"(muscle cell development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061448"(connective tissue development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:1900120"(regulation of receptor binding)|go:"GO:1903010"(regulation of bone development)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000586"(regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR001695(Lysyl oxidase)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004720"(protein-lysine 6-oxidase activity)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005507"(copper ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0007507"(heart development)|go:"GO:0009725"(response to hormone)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0018057"(peptidyl-lysine oxidation)|go:"GO:0018158"(protein oxidation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030324"(lung development)|interpro:IPR019828|mint:P28301|reactome:R-MMU-1566948|reactome:R-MMU-2243919 - - - figure legend:Figure 2C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/01/15 2020/01/24 rogid:BfvYchbBo/96KdiQW3PhuvtwUSc10090 rogid:ehv+lVMTVIzWWWxaRlO+aIY53jk10090 rigid:/EgwcWcCAHWzpmHCS+TQCdu/n9U false myc tag:?-?|his tag:?-? his tag:c-c|v5 tag:c-c - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q9H324 uniprotkb:P28301 intact:EBI-7096115|intact:MINT-8247349|uniprotkb:M0QZE4 intact:EBI-642911|ensembl:ENSMUSP00000025409|ensembl:ENSMUSP00000129247 psi-mi:ats10_human(display_long)|uniprotkb:ADAMTS10(gene name)|psi-mi:ADAMTS10(display_short) psi-mi:lyox_mouse(display_long)|uniprotkb:Lysyl oxidase(gene name synonym)|uniprotkb:Ras excision protein(gene name synonym)|uniprotkb:Lox(gene name)|psi-mi:Lox(display_short)|uniprotkb:Rrg(gene name synonym) psi-mi:"MI:0813"(proximity ligation assay) Aviram et al. (2019) pubmed:29758265|imex:IM-27643 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0917"(matrixdb) intact:EBI-25407044|imex:IM-27643-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q9H324|go:"GO:0001527"(microfibril)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0046872"(metal ion binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|reactome:R-HSA-5083635|reactome:R-HSA-5173214|refseq:NP_001269281.1|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR010909(PLAC)|interpro:IPR010294(ADAM-TS Spacer 1)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR024079|interpro:IPR002870(Peptidase M12B, propeptide)|refseq:NP_112219.3|interpro:IPR036383|interpro:IPR013273(Peptidase M12B, ADAM-TS)|interpro:IPR041645 refseq:NP_001273110.1|refseq:NP_001273111.1|refseq:NP_034858.2|ensembl:ENSMUSG00000024529(gene)|ensembl:ENSMUST00000025409(transcript)|ensembl:ENSMUST00000171470(transcript)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035904"(aorta development)|go:"GO:0035905"(ascending aorta development)|go:"GO:0035906"(descending aorta development)|go:"GO:0042060"(wound healing)|go:"GO:0001568"(blood vessel development)|go:"GO:0042493"|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0055001"(muscle cell development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061448"(connective tissue development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:1900120"(regulation of receptor binding)|go:"GO:1903010"(regulation of bone development)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000586"(regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR001695(Lysyl oxidase)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004720"(protein-lysine 6-oxidase activity)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005507"(copper ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0007507"(heart development)|go:"GO:0009725"(response to hormone)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0018057"(peptidyl-lysine oxidation)|go:"GO:0018158"(protein oxidation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030324"(lung development)|interpro:IPR019828|mint:P28301|reactome:R-MMU-1566948|reactome:R-MMU-2243919 - comment:mint|comment:homomint - figure legend:Figure 2C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/01/15 2020/01/24 rogid:Optd5kHeSeXNYN0gdCC8fCkKlTc9606 rogid:ehv+lVMTVIzWWWxaRlO+aIY53jk10090 rigid:GKGOleVd2ZRf1kxhEdA/jfDbc/I false myc tag:?-?|his tag:?-? v5 tag:c-c|his tag:c-c - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q6UY14 uniprotkb:P28301 intact:EBI-742002|uniprotkb:Q5T5F7|uniprotkb:Q6IPM6|uniprotkb:Q8N643|uniprotkb:Q9HBS6|ensembl:ENSP00000271643|ensembl:ENSP00000358034|uniprotkb:B2RTT0|uniprotkb:F8WAD0 intact:EBI-642911|ensembl:ENSMUSP00000025409|ensembl:ENSMUSP00000129247 psi-mi:atl4_human(display_long)|uniprotkb:Thrombospondin repeat-containing protein 1(gene name synonym)|uniprotkb:ADAMTSL4(gene name)|psi-mi:ADAMTSL4(display_short)|uniprotkb:TSRC1(gene name synonym)|uniprotkb:PP1396(orf name)|uniprotkb:UNQ2803/PRO34012(orf name) psi-mi:lyox_mouse(display_long)|uniprotkb:Lysyl oxidase(gene name synonym)|uniprotkb:Ras excision protein(gene name synonym)|uniprotkb:Lox(gene name)|psi-mi:Lox(display_short)|uniprotkb:Rrg(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Aviram et al. (2019) pubmed:29758265|imex:IM-27643 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0917"(matrixdb) intact:EBI-25407103|imex:IM-27643-23 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061905.2|refseq:NP_079284.2|ensembl:ENSG00000143382(gene)|ensembl:ENST00000271643(transcript)|ensembl:ENST00000369038(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0002064"(epithelial cell development)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005614"(interstitial matrix)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006915"(apoptotic process)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR010294(ADAM-TS Spacer 1)|interpro:IPR010909(PLAC)|interpro:IPR036383|mint:Q6UY14|reactome:R-HSA-5083635|reactome:R-HSA-5173214|go:"GO:0005576"(extracellular region)|refseq:NP_001275536.1|refseq:NP_001275537.1|refseq:XP_011507950.1|refseq:XP_016856995.1 refseq:NP_001273110.1|refseq:NP_001273111.1|refseq:NP_034858.2|ensembl:ENSMUSG00000024529(gene)|ensembl:ENSMUST00000025409(transcript)|ensembl:ENSMUST00000171470(transcript)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035904"(aorta development)|go:"GO:0035905"(ascending aorta development)|go:"GO:0035906"(descending aorta development)|go:"GO:0042060"(wound healing)|go:"GO:0001568"(blood vessel development)|go:"GO:0042493"|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0055001"(muscle cell development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061448"(connective tissue development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:1900120"(regulation of receptor binding)|go:"GO:1903010"(regulation of bone development)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000586"(regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR001695(Lysyl oxidase)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004720"(protein-lysine 6-oxidase activity)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005507"(copper ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0007507"(heart development)|go:"GO:0009725"(response to hormone)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0018057"(peptidyl-lysine oxidation)|go:"GO:0018158"(protein oxidation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030324"(lung development)|interpro:IPR019828|mint:P28301|reactome:R-MMU-1566948|reactome:R-MMU-2243919 - - - figure legend:Figure 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/01/15 2020/02/03 rogid:HIXY8OQopS51RVemJo0GTj8V0WQ9606 rogid:ehv+lVMTVIzWWWxaRlO+aIY53jk10090 rigid:fRJmSO7SwvFwUIGk5oBollv5L6c false flag tag:c-c|35s radiolabel:?-? 35s radiolabel:?-?|v5 tag:c-c|his tag:c-c - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q6UY14 uniprotkb:P28301 intact:EBI-742002|uniprotkb:Q5T5F7|uniprotkb:Q6IPM6|uniprotkb:Q8N643|uniprotkb:Q9HBS6|ensembl:ENSP00000271643|ensembl:ENSP00000358034|uniprotkb:B2RTT0|uniprotkb:F8WAD0 intact:EBI-642911|ensembl:ENSMUSP00000025409|ensembl:ENSMUSP00000129247 psi-mi:atl4_human(display_long)|uniprotkb:Thrombospondin repeat-containing protein 1(gene name synonym)|uniprotkb:ADAMTSL4(gene name)|psi-mi:ADAMTSL4(display_short)|uniprotkb:TSRC1(gene name synonym)|uniprotkb:PP1396(orf name)|uniprotkb:UNQ2803/PRO34012(orf name) psi-mi:lyox_mouse(display_long)|uniprotkb:Lysyl oxidase(gene name synonym)|uniprotkb:Ras excision protein(gene name synonym)|uniprotkb:Lox(gene name)|psi-mi:Lox(display_short)|uniprotkb:Rrg(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Aviram et al. (2019) pubmed:29758265|imex:IM-27643 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0917"(matrixdb) intact:EBI-25407128|imex:IM-27643-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061905.2|refseq:NP_079284.2|ensembl:ENSG00000143382(gene)|ensembl:ENST00000271643(transcript)|ensembl:ENST00000369038(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0002064"(epithelial cell development)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005614"(interstitial matrix)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006915"(apoptotic process)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR010294(ADAM-TS Spacer 1)|interpro:IPR010909(PLAC)|interpro:IPR036383|mint:Q6UY14|reactome:R-HSA-5083635|reactome:R-HSA-5173214|go:"GO:0005576"(extracellular region)|refseq:NP_001275536.1|refseq:NP_001275537.1|refseq:XP_011507950.1|refseq:XP_016856995.1 refseq:NP_001273110.1|refseq:NP_001273111.1|refseq:NP_034858.2|ensembl:ENSMUSG00000024529(gene)|ensembl:ENSMUST00000025409(transcript)|ensembl:ENSMUST00000171470(transcript)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035904"(aorta development)|go:"GO:0035905"(ascending aorta development)|go:"GO:0035906"(descending aorta development)|go:"GO:0042060"(wound healing)|go:"GO:0001568"(blood vessel development)|go:"GO:0042493"|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0055001"(muscle cell development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061448"(connective tissue development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:1900120"(regulation of receptor binding)|go:"GO:1903010"(regulation of bone development)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000586"(regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR001695(Lysyl oxidase)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004720"(protein-lysine 6-oxidase activity)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005507"(copper ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0007507"(heart development)|go:"GO:0009725"(response to hormone)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0018057"(peptidyl-lysine oxidation)|go:"GO:0018158"(protein oxidation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030324"(lung development)|interpro:IPR019828|mint:P28301|reactome:R-MMU-1566948|reactome:R-MMU-2243919 - - - figure legend:Figure 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/01/15 2020/01/24 rogid:HIXY8OQopS51RVemJo0GTj8V0WQ9606 rogid:ehv+lVMTVIzWWWxaRlO+aIY53jk10090 rigid:fRJmSO7SwvFwUIGk5oBollv5L6c false 35s radiolabel:?-?|flag tag:c-c 35s radiolabel:?-?|v5 tag:c-c|his tag:c-c - - psi-mi:"MI:0833"(autoradiography) psi-mi:"MI:0833"(autoradiography) uniprotkb:P28301 uniprotkb:Q7TSK7 intact:EBI-642911|ensembl:ENSMUSP00000025409|ensembl:ENSMUSP00000129247 intact:EBI-25406979|ensembl:ENSMUSP00000088774|uniprotkb:Q3U0C8 psi-mi:lyox_mouse(display_long)|uniprotkb:Lysyl oxidase(gene name synonym)|uniprotkb:Ras excision protein(gene name synonym)|uniprotkb:Lox(gene name)|psi-mi:Lox(display_short)|uniprotkb:Rrg(gene name synonym) psi-mi:atl2_mouse(display_long)|uniprotkb:TSP1-repeat-containing protein 1(gene name synonym)|uniprotkb:Adamtsl2(gene name)|psi-mi:Adamtsl2(display_short)|uniprotkb:Kiaa0605(gene name synonym)|uniprotkb:Tcp1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Aviram et al. (2019) pubmed:29758265|imex:IM-27643 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0917"(matrixdb) intact:EBI-25407186|imex:IM-27643-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273110.1|refseq:NP_001273111.1|refseq:NP_034858.2|ensembl:ENSMUSG00000024529(gene)|ensembl:ENSMUST00000025409(transcript)|ensembl:ENSMUST00000171470(transcript)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035904"(aorta development)|go:"GO:0035905"(ascending aorta development)|go:"GO:0035906"(descending aorta development)|go:"GO:0042060"(wound healing)|go:"GO:0001568"(blood vessel development)|go:"GO:0042493"|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0055001"(muscle cell development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061448"(connective tissue development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:1900120"(regulation of receptor binding)|go:"GO:1903010"(regulation of bone development)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000586"(regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR001695(Lysyl oxidase)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004720"(protein-lysine 6-oxidase activity)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005507"(copper ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0007507"(heart development)|go:"GO:0009725"(response to hormone)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0018057"(peptidyl-lysine oxidation)|go:"GO:0018158"(protein oxidation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030324"(lung development)|interpro:IPR019828|mint:P28301|reactome:R-MMU-1566948|reactome:R-MMU-2243919 ensembl:ENSMUSG00000036040(gene)|ensembl:ENSMUST00000091233(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0050436"(microfibril binding)|go:"GO:0060481"(lobar bronchus epithelium development)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR010294(ADAM-TS Spacer 1)|interpro:IPR010909(PLAC)|interpro:IPR013273(Peptidase M12B, ADAM-TS)|interpro:IPR036383|reactome:R-MMU-5173214|refseq:NP_084257.1 - - - figure legend:Figure 2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/01/15 2020/01/24 rogid:ehv+lVMTVIzWWWxaRlO+aIY53jk10090 rogid:BfvYchbBo/96KdiQW3PhuvtwUSc10090 rigid:/EgwcWcCAHWzpmHCS+TQCdu/n9U false his tag:c-c|v5 tag:c-c myc tag:?-?|his tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9H324 uniprotkb:P28301 intact:EBI-7096115|intact:MINT-8247349|uniprotkb:M0QZE4 intact:EBI-642911|ensembl:ENSMUSP00000025409|ensembl:ENSMUSP00000129247 psi-mi:ats10_human(display_long)|uniprotkb:ADAMTS10(gene name)|psi-mi:ADAMTS10(display_short) psi-mi:lyox_mouse(display_long)|uniprotkb:Lysyl oxidase(gene name synonym)|uniprotkb:Ras excision protein(gene name synonym)|uniprotkb:Lox(gene name)|psi-mi:Lox(display_short)|uniprotkb:Rrg(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Aviram et al. (2019) pubmed:29758265|imex:IM-27643 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0917"(matrixdb) intact:EBI-25407214|imex:IM-27643-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q9H324|go:"GO:0001527"(microfibril)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0046872"(metal ion binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|reactome:R-HSA-5083635|reactome:R-HSA-5173214|refseq:NP_001269281.1|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR010909(PLAC)|interpro:IPR010294(ADAM-TS Spacer 1)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR024079|interpro:IPR002870(Peptidase M12B, propeptide)|refseq:NP_112219.3|interpro:IPR036383|interpro:IPR013273(Peptidase M12B, ADAM-TS)|interpro:IPR041645 refseq:NP_001273110.1|refseq:NP_001273111.1|refseq:NP_034858.2|ensembl:ENSMUSG00000024529(gene)|ensembl:ENSMUST00000025409(transcript)|ensembl:ENSMUST00000171470(transcript)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035904"(aorta development)|go:"GO:0035905"(ascending aorta development)|go:"GO:0035906"(descending aorta development)|go:"GO:0042060"(wound healing)|go:"GO:0001568"(blood vessel development)|go:"GO:0042493"|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0055001"(muscle cell development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061448"(connective tissue development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:1900120"(regulation of receptor binding)|go:"GO:1903010"(regulation of bone development)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000586"(regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR001695(Lysyl oxidase)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004720"(protein-lysine 6-oxidase activity)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005507"(copper ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0007507"(heart development)|go:"GO:0009725"(response to hormone)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0018057"(peptidyl-lysine oxidation)|go:"GO:0018158"(protein oxidation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030324"(lung development)|interpro:IPR019828|mint:P28301|reactome:R-MMU-1566948|reactome:R-MMU-2243919 - comment:mint|comment:homomint - figure legend:Figure 2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/01/15 2020/01/24 rogid:Optd5kHeSeXNYN0gdCC8fCkKlTc9606 rogid:ehv+lVMTVIzWWWxaRlO+aIY53jk10090 rigid:GKGOleVd2ZRf1kxhEdA/jfDbc/I false myc tag:?-?|his tag:?-? v5 tag:c-c|his tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9Y4K0 uniprotkb:Q7TSK7 intact:EBI-7172227|ensembl:ENSP00000373783|intact:MINT-4053647|uniprotkb:Q9BW70|uniprotkb:Q53HV3|uniprotkb:Q9Y5Y8|uniprotkb:B2R5Q0 intact:EBI-25406979|ensembl:ENSMUSP00000088774|uniprotkb:Q3U0C8 psi-mi:loxl2_human(display_long)|uniprotkb:LOXL2(gene name)|psi-mi:LOXL2(display_short)|uniprotkb:Lysyl oxidase-like protein 2(gene name synonym)|uniprotkb:Lysyl oxidase-related protein 2(gene name synonym)|uniprotkb:Lysyl oxidase-related protein WS9-14(gene name synonym) psi-mi:atl2_mouse(display_long)|uniprotkb:TSP1-repeat-containing protein 1(gene name synonym)|uniprotkb:Adamtsl2(gene name)|psi-mi:Adamtsl2(display_short)|uniprotkb:Kiaa0605(gene name synonym)|uniprotkb:Tcp1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Aviram et al. (2019) pubmed:29758265|imex:IM-27643 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0917"(matrixdb) intact:EBI-25407259|imex:IM-27643-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000134013(gene)|ensembl:ENST00000389131(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0004720"(protein-lysine 6-oxidase activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007155"(cell adhesion)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0007568"(aging)|go:"GO:0009055"(electron transfer activity)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016020"(membrane)|go:"GO:0018057"(peptidyl-lysine oxidation)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046688"(response to copper ion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070492"(oligosaccharide binding)|go:"GO:0070828"(heterochromatin organization)|go:"GO:1902455"(negative regulation of stem cell population maintenance)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR001695(Lysyl oxidase)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR019828|interpro:IPR036772|mint:Q9Y4K0|rcsb pdb:5ZE3|reactome:R-HSA-1566948|reactome:R-HSA-2243919|go:"GO:0030199"(collagen fibril organization)|refseq:NP_002309.1 ensembl:ENSMUSG00000036040(gene)|ensembl:ENSMUST00000091233(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0050436"(microfibril binding)|go:"GO:0060481"(lobar bronchus epithelium development)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR010294(ADAM-TS Spacer 1)|interpro:IPR010909(PLAC)|interpro:IPR013273(Peptidase M12B, ADAM-TS)|interpro:IPR036383|reactome:R-MMU-5173214|refseq:NP_084257.1 - comment:mint - figure legend:Figure 3C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/01/15 2020/01/24 rogid:F7xjdY5T+JdpyIAsi2BmXPzqz+A9606 rogid:BfvYchbBo/96KdiQW3PhuvtwUSc10090 rigid:chnkVZCirz3HEbZh8TmsP4Uv3uU false v5 tag:?-? myc tag:?-?|his tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9H324 uniprotkb:Q9Y4K0 intact:EBI-7096115|intact:MINT-8247349|uniprotkb:M0QZE4 intact:EBI-7172227|ensembl:ENSP00000373783|intact:MINT-4053647|uniprotkb:Q9BW70|uniprotkb:Q53HV3|uniprotkb:Q9Y5Y8|uniprotkb:B2R5Q0 psi-mi:ats10_human(display_long)|uniprotkb:ADAMTS10(gene name)|psi-mi:ADAMTS10(display_short) psi-mi:loxl2_human(display_long)|uniprotkb:LOXL2(gene name)|psi-mi:LOXL2(display_short)|uniprotkb:Lysyl oxidase-like protein 2(gene name synonym)|uniprotkb:Lysyl oxidase-related protein 2(gene name synonym)|uniprotkb:Lysyl oxidase-related protein WS9-14(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Aviram et al. (2019) pubmed:29758265|imex:IM-27643 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0917"(matrixdb) intact:EBI-25407298|imex:IM-27643-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q9H324|go:"GO:0001527"(microfibril)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0046872"(metal ion binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|reactome:R-HSA-5083635|reactome:R-HSA-5173214|refseq:NP_001269281.1|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR010909(PLAC)|interpro:IPR010294(ADAM-TS Spacer 1)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR024079|interpro:IPR002870(Peptidase M12B, propeptide)|refseq:NP_112219.3|interpro:IPR036383|interpro:IPR013273(Peptidase M12B, ADAM-TS)|interpro:IPR041645 ensembl:ENSG00000134013(gene)|ensembl:ENST00000389131(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0004720"(protein-lysine 6-oxidase activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007155"(cell adhesion)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0007568"(aging)|go:"GO:0009055"(electron transfer activity)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016020"(membrane)|go:"GO:0018057"(peptidyl-lysine oxidation)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046688"(response to copper ion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070492"(oligosaccharide binding)|go:"GO:0070828"(heterochromatin organization)|go:"GO:1902455"(negative regulation of stem cell population maintenance)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR001695(Lysyl oxidase)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR019828|interpro:IPR036772|mint:Q9Y4K0|rcsb pdb:5ZE3|reactome:R-HSA-1566948|reactome:R-HSA-2243919|go:"GO:0030199"(collagen fibril organization)|refseq:NP_002309.1 - comment:mint|comment:homomint comment:mint figure legend:Figure 3C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/01/15 2020/01/24 rogid:Optd5kHeSeXNYN0gdCC8fCkKlTc9606 rogid:F7xjdY5T+JdpyIAsi2BmXPzqz+A9606 rigid:Tbel7S0d5CgSwDll2I0MRL99Fv0 false myc tag:?-?|his tag:?-? v5 tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q7TSK7 uniprotkb:P58215 intact:EBI-25406979|ensembl:ENSMUSP00000088774|uniprotkb:Q3U0C8 intact:EBI-723960|ensembl:ENSP00000264094|uniprotkb:Q96RS1|uniprotkb:D6W5J1|uniprotkb:Q2EHP2|uniprotkb:Q6IPL7 psi-mi:atl2_mouse(display_long)|uniprotkb:TSP1-repeat-containing protein 1(gene name synonym)|uniprotkb:Adamtsl2(gene name)|psi-mi:Adamtsl2(display_short)|uniprotkb:Kiaa0605(gene name synonym)|uniprotkb:Tcp1(gene name synonym) psi-mi:loxl3_human(display_long)|uniprotkb:Lysyl oxidase-like protein 3(gene name synonym)|uniprotkb:LOXL3(gene name)|psi-mi:LOXL3(display_short)|uniprotkb:LOXL(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Aviram et al. (2019) pubmed:29758265|imex:IM-27643 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0917"(matrixdb) intact:EBI-25407317|imex:IM-27643-25 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000036040(gene)|ensembl:ENSMUST00000091233(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0050436"(microfibril binding)|go:"GO:0060481"(lobar bronchus epithelium development)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR010294(ADAM-TS Spacer 1)|interpro:IPR010909(PLAC)|interpro:IPR013273(Peptidase M12B, ADAM-TS)|interpro:IPR036383|reactome:R-MMU-5173214|refseq:NP_084257.1 refseq:NP_115992.1|ensembl:ENSG00000115318(gene)|ensembl:ENST00000264094(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0016020"(membrane)|go:"GO:0018057"(peptidyl-lysine oxidation)|go:"GO:0021510"(spinal cord development)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030324"(lung development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0060021"(roof of mouth development)|go:"GO:0061053"(somite development)|go:"GO:1905590"(fibronectin fibril organization)|go:"GO:2000329"(negative regulation of T-helper 17 cell lineage commitment)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR001695(Lysyl oxidase)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR019828|interpro:IPR036772|reactome:R-HSA-1566948|go:"GO:0001837"(epithelial to mesenchymal transition)|reactome:R-HSA-2243919|go:"GO:0001968"(fibronectin binding)|go:"GO:0004720"(protein-lysine 6-oxidase activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|refseq:XP_011531436.1|refseq:NP_001276094.1|refseq:NP_001276093.1|refseq:XP_016860601.1 - - - figure legend:Figure 3A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/01/15 2020/01/24 rogid:BfvYchbBo/96KdiQW3PhuvtwUSc10090 rogid:ZemGKB4zxFQQW1MbA4fiP/NX7ow9606 rigid:xYfIKm03Iv/N91F3oAbTI3m1EHA false myc tag:?-?|his tag:?-? v5 tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q7TSK7 uniprotkb:P58215 intact:EBI-25406979|ensembl:ENSMUSP00000088774|uniprotkb:Q3U0C8 intact:EBI-723960|ensembl:ENSP00000264094|uniprotkb:Q96RS1|uniprotkb:D6W5J1|uniprotkb:Q2EHP2|uniprotkb:Q6IPL7 psi-mi:atl2_mouse(display_long)|uniprotkb:TSP1-repeat-containing protein 1(gene name synonym)|uniprotkb:Adamtsl2(gene name)|psi-mi:Adamtsl2(display_short)|uniprotkb:Kiaa0605(gene name synonym)|uniprotkb:Tcp1(gene name synonym) psi-mi:loxl3_human(display_long)|uniprotkb:Lysyl oxidase-like protein 3(gene name synonym)|uniprotkb:LOXL3(gene name)|psi-mi:LOXL3(display_short)|uniprotkb:LOXL(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Aviram et al. (2019) pubmed:29758265|imex:IM-27643 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0917"(matrixdb) intact:EBI-25407346|imex:IM-27643-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000036040(gene)|ensembl:ENSMUST00000091233(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0050436"(microfibril binding)|go:"GO:0060481"(lobar bronchus epithelium development)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR010294(ADAM-TS Spacer 1)|interpro:IPR010909(PLAC)|interpro:IPR013273(Peptidase M12B, ADAM-TS)|interpro:IPR036383|reactome:R-MMU-5173214|refseq:NP_084257.1 refseq:NP_115992.1|ensembl:ENSG00000115318(gene)|ensembl:ENST00000264094(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0016020"(membrane)|go:"GO:0018057"(peptidyl-lysine oxidation)|go:"GO:0021510"(spinal cord development)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030324"(lung development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0060021"(roof of mouth development)|go:"GO:0061053"(somite development)|go:"GO:1905590"(fibronectin fibril organization)|go:"GO:2000329"(negative regulation of T-helper 17 cell lineage commitment)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR001695(Lysyl oxidase)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR019828|interpro:IPR036772|reactome:R-HSA-1566948|go:"GO:0001837"(epithelial to mesenchymal transition)|reactome:R-HSA-2243919|go:"GO:0001968"(fibronectin binding)|go:"GO:0004720"(protein-lysine 6-oxidase activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|refseq:XP_011531436.1|refseq:NP_001276094.1|refseq:NP_001276093.1|refseq:XP_016860601.1 - - - figure legend:Figure 3B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/01/15 2020/01/24 rogid:BfvYchbBo/96KdiQW3PhuvtwUSc10090 rogid:ZemGKB4zxFQQW1MbA4fiP/NX7ow9606 rigid:xYfIKm03Iv/N91F3oAbTI3m1EHA false his tag:?-?|myc tag:?-? v5 tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q7TSK7 uniprotkb:P28301 intact:EBI-25406979|ensembl:ENSMUSP00000088774|uniprotkb:Q3U0C8 intact:EBI-642911|ensembl:ENSMUSP00000025409|ensembl:ENSMUSP00000129247 psi-mi:atl2_mouse(display_long)|uniprotkb:TSP1-repeat-containing protein 1(gene name synonym)|uniprotkb:Adamtsl2(gene name)|psi-mi:Adamtsl2(display_short)|uniprotkb:Kiaa0605(gene name synonym)|uniprotkb:Tcp1(gene name synonym) psi-mi:lyox_mouse(display_long)|uniprotkb:Lysyl oxidase(gene name synonym)|uniprotkb:Ras excision protein(gene name synonym)|uniprotkb:Lox(gene name)|psi-mi:Lox(display_short)|uniprotkb:Rrg(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Aviram et al. (2019) pubmed:29758265|imex:IM-27643 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0917"(matrixdb) intact:EBI-25407383|imex:IM-27643-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000036040(gene)|ensembl:ENSMUST00000091233(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0050436"(microfibril binding)|go:"GO:0060481"(lobar bronchus epithelium development)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR010294(ADAM-TS Spacer 1)|interpro:IPR010909(PLAC)|interpro:IPR013273(Peptidase M12B, ADAM-TS)|interpro:IPR036383|reactome:R-MMU-5173214|refseq:NP_084257.1 refseq:NP_001273110.1|refseq:NP_001273111.1|refseq:NP_034858.2|ensembl:ENSMUSG00000024529(gene)|ensembl:ENSMUST00000025409(transcript)|ensembl:ENSMUST00000171470(transcript)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035904"(aorta development)|go:"GO:0035905"(ascending aorta development)|go:"GO:0035906"(descending aorta development)|go:"GO:0042060"(wound healing)|go:"GO:0001568"(blood vessel development)|go:"GO:0042493"|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0055001"(muscle cell development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061448"(connective tissue development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:1900120"(regulation of receptor binding)|go:"GO:1903010"(regulation of bone development)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000586"(regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR001695(Lysyl oxidase)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004720"(protein-lysine 6-oxidase activity)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005507"(copper ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0007507"(heart development)|go:"GO:0009725"(response to hormone)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0018057"(peptidyl-lysine oxidation)|go:"GO:0018158"(protein oxidation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030324"(lung development)|interpro:IPR019828|mint:P28301|reactome:R-MMU-1566948|reactome:R-MMU-2243919 - - - figure legend:Figure 2B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/01/15 2020/01/24 rogid:BfvYchbBo/96KdiQW3PhuvtwUSc10090 rogid:ehv+lVMTVIzWWWxaRlO+aIY53jk10090 rigid:/EgwcWcCAHWzpmHCS+TQCdu/n9U false his tag:?-?|myc tag:?-? v5 tag:c-c|his tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9H324 uniprotkb:P28301 intact:EBI-7096115|intact:MINT-8247349|uniprotkb:M0QZE4 intact:EBI-642911|ensembl:ENSMUSP00000025409|ensembl:ENSMUSP00000129247 psi-mi:ats10_human(display_long)|uniprotkb:ADAMTS10(gene name)|psi-mi:ADAMTS10(display_short) psi-mi:lyox_mouse(display_long)|uniprotkb:Lysyl oxidase(gene name synonym)|uniprotkb:Ras excision protein(gene name synonym)|uniprotkb:Lox(gene name)|psi-mi:Lox(display_short)|uniprotkb:Rrg(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Aviram et al. (2019) pubmed:29758265|imex:IM-27643 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0917"(matrixdb) intact:EBI-25407391|imex:IM-27643-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q9H324|go:"GO:0001527"(microfibril)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0046872"(metal ion binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|reactome:R-HSA-5083635|reactome:R-HSA-5173214|refseq:NP_001269281.1|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR010909(PLAC)|interpro:IPR010294(ADAM-TS Spacer 1)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR024079|interpro:IPR002870(Peptidase M12B, propeptide)|refseq:NP_112219.3|interpro:IPR036383|interpro:IPR013273(Peptidase M12B, ADAM-TS)|interpro:IPR041645 refseq:NP_001273110.1|refseq:NP_001273111.1|refseq:NP_034858.2|ensembl:ENSMUSG00000024529(gene)|ensembl:ENSMUST00000025409(transcript)|ensembl:ENSMUST00000171470(transcript)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035904"(aorta development)|go:"GO:0035905"(ascending aorta development)|go:"GO:0035906"(descending aorta development)|go:"GO:0042060"(wound healing)|go:"GO:0001568"(blood vessel development)|go:"GO:0042493"|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0055001"(muscle cell development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061448"(connective tissue development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:1900120"(regulation of receptor binding)|go:"GO:1903010"(regulation of bone development)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000586"(regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR001695(Lysyl oxidase)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004720"(protein-lysine 6-oxidase activity)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005507"(copper ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0007507"(heart development)|go:"GO:0009725"(response to hormone)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0018057"(peptidyl-lysine oxidation)|go:"GO:0018158"(protein oxidation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030324"(lung development)|interpro:IPR019828|mint:P28301|reactome:R-MMU-1566948|reactome:R-MMU-2243919 - comment:mint|comment:homomint - figure legend:Figure 2B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/01/15 2020/01/24 rogid:Optd5kHeSeXNYN0gdCC8fCkKlTc9606 rogid:ehv+lVMTVIzWWWxaRlO+aIY53jk10090 rigid:GKGOleVd2ZRf1kxhEdA/jfDbc/I false myc tag:?-?|his tag:?-? v5 tag:c-c|his tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)