#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P78504	uniprotkb:Q92743	intact:EBI-2847071|uniprotkb:B4DYR1|uniprotkb:E9PCF9|uniprotkb:O14902|uniprotkb:A0AV43|uniprotkb:O15122|uniprotkb:Q15816|ensembl:ENSP00000254958	intact:EBI-352256|uniprotkb:Q9UNS5|uniprotkb:D3DRE4|ensembl:ENSP00000357980	psi-mi:jag1_human(display_long)|uniprotkb:JAG1(gene name)|psi-mi:JAG1(display_short)|uniprotkb:JAGL1(gene name synonym)	psi-mi:htra1_human(display_long)|uniprotkb:HTRA1(gene name)|psi-mi:HTRA1(display_short)|uniprotkb:HTRA(gene name synonym)|uniprotkb:PRSS11(gene name synonym)|uniprotkb:High-temperature requirement A serine peptidase 1(gene name synonym)|uniprotkb:L56(gene name synonym)|uniprotkb:Serine protease 11(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Klose et al. (2018)	pubmed:29713059|imex:IM-28317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25823862|imex:IM-28317-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016883196.1|refseq:NP_000205.1|ensembl:ENST00000254958(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001709"(cell fate determination)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0005112"(Notch binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007399"(nervous system development)|ensembl:ENSG00000101384(gene)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045639"(positive regulation of myeloid cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061073"(ciliary body morphogenesis)|go:"GO:0061156"(pulmonary artery morphogenesis)|go:"GO:0061309"(cardiac neural crest cell development involved in outflow tract morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0061444"(endocardial cushion cell development)|go:"GO:0062043"(positive regulation of cardiac epithelial to mesenchymal transition)|go:"GO:0072006"(nephron development)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0072017"(distal tubule development)|go:"GO:0072070"(loop of Henle development)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001774("Delta/Serrate/lag-2 (DSL) protein")|go:"GO:0008083"(growth factor activity)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011651(Notch ligand, N-terminal)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR026219|interpro:IPR033108|rcsb pdb:2KB9|rcsb pdb:2VJ2|rcsb pdb:4CBZ|rcsb pdb:4CC0|rcsb pdb:4CC1|rcsb pdb:4XI7|rcsb pdb:5BO1|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-8941856|reactome:R-HSA-9013149|reactome:R-HSA-9013423|reactome:R-HSA-9013507|reactome:R-HSA-9013700|interpro:IPR001881(EGF-like calcium-binding)|dip:DIP-46371N	refseq:NP_002766.1|ensembl:ENSG00000166033(gene)|ensembl:ENST00000368984(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097187"(dentinogenesis)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058|interpro:IPR041489|rcsb pdb:2JOA|rcsb pdb:2YTW|rcsb pdb:3NUM|rcsb pdb:3NWU|rcsb pdb:3NZI|rcsb pdb:3TJN|rcsb pdb:3TJO|rcsb pdb:3TJQ|rcsb pdb:6Z0E|rcsb pdb:6Z0X|rcsb pdb:6Z0Y|reactome:R-HSA-1474228|dip:DIP-33195N	-	-	-	figure legend:3G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/03/11	2020/09/04	rogid:kaBPZjsO7mchlR6vYIknqvTluos9606	rogid:Y7lT7nyI9N/3imHOz8Ng+Zagf509606	rigid:uHVuJyQf0wpPQ18mZ95JCr1wVUU	false	necessary binding region:1214-1218	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9R118	uniprotkb:P78504	intact:EBI-25823886|ensembl:ENSMUSP00000006367|uniprotkb:Q8BN04|uniprotkb:Q8BN05|uniprotkb:Q91WS3|uniprotkb:Q9QZK6	intact:EBI-2847071|uniprotkb:B4DYR1|uniprotkb:E9PCF9|uniprotkb:O14902|uniprotkb:A0AV43|uniprotkb:O15122|uniprotkb:Q15816|ensembl:ENSP00000254958	psi-mi:htra1_mouse(display_long)|uniprotkb:Htra1(gene name)|psi-mi:Htra1(display_short)|uniprotkb:Htra(gene name synonym)|uniprotkb:Prss11(gene name synonym)|uniprotkb:High-temperature requirement A serine peptidase 1(gene name synonym)|uniprotkb:Serine protease 11(gene name synonym)	psi-mi:jag1_human(display_long)|uniprotkb:JAG1(gene name)|psi-mi:JAG1(display_short)|uniprotkb:JAGL1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Klose et al. (2018)	pubmed:29713059|imex:IM-28317	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25823881|imex:IM-28317-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000006205(gene)|ensembl:ENSMUST00000006367(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0097187"(dentinogenesis)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058|interpro:IPR041489|reactome:R-MMU-1474228|refseq:NP_062510.2	refseq:XP_016883196.1|refseq:NP_000205.1|ensembl:ENST00000254958(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001709"(cell fate determination)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0005112"(Notch binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007399"(nervous system development)|ensembl:ENSG00000101384(gene)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045639"(positive regulation of myeloid cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061073"(ciliary body morphogenesis)|go:"GO:0061156"(pulmonary artery morphogenesis)|go:"GO:0061309"(cardiac neural crest cell development involved in outflow tract morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0061444"(endocardial cushion cell development)|go:"GO:0062043"(positive regulation of cardiac epithelial to mesenchymal transition)|go:"GO:0072006"(nephron development)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0072017"(distal tubule development)|go:"GO:0072070"(loop of Henle development)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001774("Delta/Serrate/lag-2 (DSL) protein")|go:"GO:0008083"(growth factor activity)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011651(Notch ligand, N-terminal)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR026219|interpro:IPR033108|rcsb pdb:2KB9|rcsb pdb:2VJ2|rcsb pdb:4CBZ|rcsb pdb:4CC0|rcsb pdb:4CC1|rcsb pdb:4XI7|rcsb pdb:5BO1|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-8941856|reactome:R-HSA-9013149|reactome:R-HSA-9013423|reactome:R-HSA-9013507|reactome:R-HSA-9013700|interpro:IPR001881(EGF-like calcium-binding)|dip:DIP-46371N	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/03/11	2020/09/04	rogid:/YkEE1zD5Iotj5SWGZoK2+LNc0410090	rogid:kaBPZjsO7mchlR6vYIknqvTluos9606	rigid:cvB5zASZY9SPiTZVqFM5RGLASwE	false	-	sufficient binding region:1094..1094-1218..1218	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:A0A140LI67	uniprotkb:P78504	intact:EBI-25823933|ensembl:ENSMUSP00000146693	intact:EBI-2847071|uniprotkb:B4DYR1|uniprotkb:E9PCF9|uniprotkb:O14902|uniprotkb:A0AV43|uniprotkb:O15122|uniprotkb:Q15816|ensembl:ENSP00000254958	psi-mi:a0a140li67_mouse(display_long)|uniprotkb:Frmpd2(gene name)|psi-mi:Frmpd2(display_short)|uniprotkb:Gm626(gene name synonym)	psi-mi:jag1_human(display_long)|uniprotkb:JAG1(gene name)|psi-mi:JAG1(display_short)|uniprotkb:JAGL1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Klose et al. (2018)	pubmed:29713059|imex:IM-28317	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25823926|imex:IM-28317-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000108841(gene)|ensembl:ENSMUST00000208577(transcript)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0070830"(bicellular tight junction assembly)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR011019(KIND)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR029906|interpro:IPR035963|interpro:IPR036034|rcsb pdb:5ZDS	refseq:XP_016883196.1|refseq:NP_000205.1|ensembl:ENST00000254958(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001709"(cell fate determination)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0005112"(Notch binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007399"(nervous system development)|ensembl:ENSG00000101384(gene)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045639"(positive regulation of myeloid cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061073"(ciliary body morphogenesis)|go:"GO:0061156"(pulmonary artery morphogenesis)|go:"GO:0061309"(cardiac neural crest cell development involved in outflow tract morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0061444"(endocardial cushion cell development)|go:"GO:0062043"(positive regulation of cardiac epithelial to mesenchymal transition)|go:"GO:0072006"(nephron development)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0072017"(distal tubule development)|go:"GO:0072070"(loop of Henle development)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001774("Delta/Serrate/lag-2 (DSL) protein")|go:"GO:0008083"(growth factor activity)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011651(Notch ligand, N-terminal)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR026219|interpro:IPR033108|rcsb pdb:2KB9|rcsb pdb:2VJ2|rcsb pdb:4CBZ|rcsb pdb:4CC0|rcsb pdb:4CC1|rcsb pdb:4XI7|rcsb pdb:5BO1|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-8941856|reactome:R-HSA-9013149|reactome:R-HSA-9013423|reactome:R-HSA-9013507|reactome:R-HSA-9013700|interpro:IPR001881(EGF-like calcium-binding)|dip:DIP-46371N	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/03/11	2020/09/04	rogid:FC2hBd3jtbwMJXGotAZX/IEIoss10090	rogid:kaBPZjsO7mchlR6vYIknqvTluos9606	rigid:D+QZAqupl2zeOY8xHKHGpjxj/U8	false	-	sufficient binding region:1094..1094-1218..1218	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9WV34	uniprotkb:P78504	intact:EBI-444614|ensembl:ENSMUSP00000017458|uniprotkb:Q3T9W1|uniprotkb:Q3TT52|uniprotkb:Q3URK8|uniprotkb:B1AQF8	intact:EBI-2847071|uniprotkb:B4DYR1|uniprotkb:E9PCF9|uniprotkb:O14902|uniprotkb:A0AV43|uniprotkb:O15122|uniprotkb:Q15816|ensembl:ENSP00000254958	psi-mi:mpp2_mouse(display_long)|uniprotkb:Protein MPP2(gene name synonym)|uniprotkb:Discs large homolog 2(gene name synonym)|uniprotkb:Mpp2(gene name)|psi-mi:Mpp2(display_short)|uniprotkb:Dlgh2(gene name synonym)	psi-mi:jag1_human(display_long)|uniprotkb:JAG1(gene name)|psi-mi:JAG1(display_short)|uniprotkb:JAGL1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Klose et al. (2018)	pubmed:29713059|imex:IM-28317	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25823962|imex:IM-28317-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057904.1|ensembl:ENSMUSG00000017314(gene)|ensembl:ENSMUST00000017458(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0032590"(dendrite membrane)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR014775(L27, C-terminal)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035602|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|mint:Q9WV34|go:"GO:0098919"(structural constituent of postsynaptic density)|refseq:XP_006533746.1|refseq:XP_006533747.1|refseq:XP_006533748.1	refseq:XP_016883196.1|refseq:NP_000205.1|ensembl:ENST00000254958(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001709"(cell fate determination)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0005112"(Notch binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007399"(nervous system development)|ensembl:ENSG00000101384(gene)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045639"(positive regulation of myeloid cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061073"(ciliary body morphogenesis)|go:"GO:0061156"(pulmonary artery morphogenesis)|go:"GO:0061309"(cardiac neural crest cell development involved in outflow tract morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0061444"(endocardial cushion cell development)|go:"GO:0062043"(positive regulation of cardiac epithelial to mesenchymal transition)|go:"GO:0072006"(nephron development)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0072017"(distal tubule development)|go:"GO:0072070"(loop of Henle development)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001774("Delta/Serrate/lag-2 (DSL) protein")|go:"GO:0008083"(growth factor activity)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011651(Notch ligand, N-terminal)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR026219|interpro:IPR033108|rcsb pdb:2KB9|rcsb pdb:2VJ2|rcsb pdb:4CBZ|rcsb pdb:4CC0|rcsb pdb:4CC1|rcsb pdb:4XI7|rcsb pdb:5BO1|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-8941856|reactome:R-HSA-9013149|reactome:R-HSA-9013423|reactome:R-HSA-9013507|reactome:R-HSA-9013700|interpro:IPR001881(EGF-like calcium-binding)|dip:DIP-46371N	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/03/11	2020/09/04	rogid:KythGhvpyj7gkND18iMe73LgdtM10090	rogid:kaBPZjsO7mchlR6vYIknqvTluos9606	rigid:6/O2ydNi3mTbuuRgO9f6ofnWn1c	false	-	sufficient binding region:1094..1094-1218..1218	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O08992	uniprotkb:P78504	intact:EBI-538265|uniprotkb:A2AKJ7|uniprotkb:Q544P5|ensembl:ENSMUSP00000029912	intact:EBI-2847071|uniprotkb:B4DYR1|uniprotkb:E9PCF9|uniprotkb:O14902|uniprotkb:A0AV43|uniprotkb:O15122|uniprotkb:Q15816|ensembl:ENSP00000254958	psi-mi:sdcb1_mouse(display_long)|uniprotkb:Syndecan-binding protein 1(gene name synonym)|uniprotkb:Scaffold protein Pbp1(gene name synonym)|uniprotkb:Sdcbp(gene name)|psi-mi:Sdcbp(display_short)	psi-mi:jag1_human(display_long)|uniprotkb:JAG1(gene name)|psi-mi:JAG1(display_short)|uniprotkb:JAGL1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Klose et al. (2018)	pubmed:29713059|imex:IM-28317	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25823968|imex:IM-28317-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001091697.1|refseq:NP_058087.2|refseq:XP_006538147.1|reactome:R-MMU-5213460|reactome:R-MMU-5675482|reactome:R-MMU-6798695|reactome:R-MMU-447043|ensembl:ENSMUSG00000028249(gene)|ensembl:ENSMUST00000029912(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005109"(frizzled binding)|go:"GO:0005137"(interleukin-5 receptor binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005895"(interleukin-5 receptor complex)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045545"(syndecan binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0099054"(presynapse assembly)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR030528|interpro:IPR036034|mint:O08992|reactome:R-MMU-3928664	refseq:XP_016883196.1|refseq:NP_000205.1|ensembl:ENST00000254958(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001709"(cell fate determination)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0005112"(Notch binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007399"(nervous system development)|ensembl:ENSG00000101384(gene)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045639"(positive regulation of myeloid cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061073"(ciliary body morphogenesis)|go:"GO:0061156"(pulmonary artery morphogenesis)|go:"GO:0061309"(cardiac neural crest cell development involved in outflow tract morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0061444"(endocardial cushion cell development)|go:"GO:0062043"(positive regulation of cardiac epithelial to mesenchymal transition)|go:"GO:0072006"(nephron development)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0072017"(distal tubule development)|go:"GO:0072070"(loop of Henle development)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001774("Delta/Serrate/lag-2 (DSL) protein")|go:"GO:0008083"(growth factor activity)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011651(Notch ligand, N-terminal)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR026219|interpro:IPR033108|rcsb pdb:2KB9|rcsb pdb:2VJ2|rcsb pdb:4CBZ|rcsb pdb:4CC0|rcsb pdb:4CC1|rcsb pdb:4XI7|rcsb pdb:5BO1|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-8941856|reactome:R-HSA-9013149|reactome:R-HSA-9013423|reactome:R-HSA-9013507|reactome:R-HSA-9013700|interpro:IPR001881(EGF-like calcium-binding)|dip:DIP-46371N	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/03/11	2020/09/04	rogid:/hMRO9ZA+m3lU6+RgIvyEr/a1+w10090	rogid:kaBPZjsO7mchlR6vYIknqvTluos9606	rigid:FsLWCj1GR8Nv+5I4mUl4ChRYk/o	false	-	sufficient binding region:1094..1094-1218..1218	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)