#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P17927	matrixdb:MULT_82_human	intact:EBI-2807625|ensembl:ENSP00000356018|ensembl:ENSP00000356020|ensembl:ENSP00000383744|uniprotkb:Q5SR43|uniprotkb:Q9UQV2|uniprotkb:Q5SR45|uniprotkb:Q16745|uniprotkb:Q16744	intact:EBI-6264901|reactome:R-HSA-173579|wwpdb:1PK6|wwpdb:2wnv|wwpdb:2jg8|wwpdb:2jg9|wwpdb:2wnu|reactome:R-HSA-173588	psi-mi:cr1_human(display_long)|uniprotkb:CR1(gene name)|psi-mi:CR1(display_short)|uniprotkb:C3BR(gene name synonym)|uniprotkb:C3b/C4b receptor(gene name synonym)	psi-mi:c1q_human(display_short)|psi-mi:MULT_82_human(display_long)|intact:Complement component C1q complex(complex recommended name)|intact:C1q(complex synonym)|intact:Complement 1q(complex synonym)|intact:C1QA-C1QB-C1QC complex(complex synonym)|intact:"6xC1QA:6xC1QB:6xC1QC"(complex systematic name)	psi-mi:"MI:0107"(surface plasmon resonance)	Jacquet et al. (2017)	pubmed:29563915|imex:IM-29085	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27033107|imex:IM-29085-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	ensembl:ENSG00000203710(gene)|go:"GO:0001855"(complement component C4b binding)|go:"GO:0001861"(complement component C4b receptor activity)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0001971"(negative regulation of activation of membrane attack complex)|go:"GO:0002430"(complement receptor mediated signaling pathway)|go:"GO:0002435"(immune complex clearance by erythrocytes)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004877"(complement component C3b receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005856"(cytoskeleton)|ensembl:ENST00000367051(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000367053(transcript)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|ensembl:ENST00000400960(transcript)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045916"(negative regulation of complement activation)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045957"(negative regulation of complement activation, alternative pathway)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900004"(negative regulation of serine-type endopeptidase activity)|go:"GO:1900005"(positive regulation of serine-type endopeptidase activity)|go:"GO:1900099"(negative regulation of plasma cell differentiation)|go:"GO:1904669"(ATP export)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|rcsb pdb:1GKG|rcsb pdb:1GKN|rcsb pdb:1GOP|rcsb pdb:1PPQ|rcsb pdb:2MCY|rcsb pdb:2MCZ|rcsb pdb:2Q7Z|reactome:R-HSA-6798695|reactome:R-HSA-8877330|reactome:R-HSA-977606|rcsb pdb:5FO9|refseq:NP_000564.2|refseq:NP_000642.3	go:"GO:0005509"(calcium ion binding)|go:"GO:0019865"(immunoglobulin binding)|efo:"MONDO:0013343"(see-also)|pubmed:28601358(see-also)|pubmed:22536204(see-also)|intact:EBI-6264878(exp-evidence)|evidence ontology:"ECO:0000353"|complex portal:CPX-1919(complex-primary)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0005576"(extracellular region)|pubmed:20548024(see-also)|pubmed:29449492(see-also)|pubmed:18250442(see-also)|go:"GO:0062167"(complement component C1q complex)|pubmed:31165008(see-also)|pubmed:27914690(see-also)|pubmed:26489954(see-also)	-	-	disease:"Complement component C1q deficiency (C1QD) [MONDO:0013343]: a disorder caused by impaired activation of the complement classical pathway. It generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis."|complex-properties:The complex comprises of six heterotrimeric collagen-like triple helices, formed from triplets of the A, B, and C chains, that associate in their N-terminal half to form a stalk, then diverge to form individual stems, each terminating in a C-terminal globular domain. Each of the six heterotrimeric globular heads or domains is made up of the globular domains from one A, one B, and one C chain, each of which in turn has its own ligand specificity. The six collagen-like stalks appear to be fibril-like and exist in the central region. The collagen-like region and the globular heads can independently interact with a multiplicity of biological structures including pathogen-associated and cell associated molecules, also each of the individual globular head domains is capable of independently interacting with specific ligands. Chains A and B are disulfide-linked whilst the C chain forms a disulfide bond with the C chain of the next strand.     Molecular weight 460 kDa.|curated-complex:"Recognition unit of the classical pathway of complement which associates with the Ca2+ - dependent C1r(2)-C1s(2) tetramer to form C1 (CPX-1920), the first component of the classical complement system. The complex's role in C1 is the recognition of immune complexes, or other molecules, which trigger the classical pathway of the complement system. Independent of complement activation C1q appears to have additional roles in homeostasis and cellular development, superoxide (O2-) production by neutrophils, blood coagulation and neurological synapse pruning."|complex-assembly:Heterooctadecamer	figure legend:1A, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:4.9x10^-10(molar)	2020/12/18	2021/07/14	rogid:gwNvQZmPMP1PCX8z/svSxkVBZt49606	-	-	false	sufficient binding region:42-1971|his tag:c-c|mutation:1208-1208	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P17927	matrixdb:MULT_82_human	intact:EBI-2807625|ensembl:ENSP00000356018|ensembl:ENSP00000356020|ensembl:ENSP00000383744|uniprotkb:Q5SR43|uniprotkb:Q9UQV2|uniprotkb:Q5SR45|uniprotkb:Q16745|uniprotkb:Q16744	intact:EBI-6264901|reactome:R-HSA-173579|wwpdb:1PK6|wwpdb:2wnv|wwpdb:2jg8|wwpdb:2jg9|wwpdb:2wnu|reactome:R-HSA-173588	psi-mi:cr1_human(display_long)|uniprotkb:CR1(gene name)|psi-mi:CR1(display_short)|uniprotkb:C3BR(gene name synonym)|uniprotkb:C3b/C4b receptor(gene name synonym)	psi-mi:c1q_human(display_short)|psi-mi:MULT_82_human(display_long)|intact:Complement component C1q complex(complex recommended name)|intact:C1q(complex synonym)|intact:Complement 1q(complex synonym)|intact:C1QA-C1QB-C1QC complex(complex synonym)|intact:"6xC1QA:6xC1QB:6xC1QC"(complex systematic name)	psi-mi:"MI:0107"(surface plasmon resonance)	Jacquet et al. (2017)	pubmed:29563915|imex:IM-29085	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27033174|imex:IM-29085-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	ensembl:ENSG00000203710(gene)|go:"GO:0001855"(complement component C4b binding)|go:"GO:0001861"(complement component C4b receptor activity)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0001971"(negative regulation of activation of membrane attack complex)|go:"GO:0002430"(complement receptor mediated signaling pathway)|go:"GO:0002435"(immune complex clearance by erythrocytes)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004877"(complement component C3b receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005856"(cytoskeleton)|ensembl:ENST00000367051(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000367053(transcript)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|ensembl:ENST00000400960(transcript)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045916"(negative regulation of complement activation)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045957"(negative regulation of complement activation, alternative pathway)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900004"(negative regulation of serine-type endopeptidase activity)|go:"GO:1900005"(positive regulation of serine-type endopeptidase activity)|go:"GO:1900099"(negative regulation of plasma cell differentiation)|go:"GO:1904669"(ATP export)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|rcsb pdb:1GKG|rcsb pdb:1GKN|rcsb pdb:1GOP|rcsb pdb:1PPQ|rcsb pdb:2MCY|rcsb pdb:2MCZ|rcsb pdb:2Q7Z|reactome:R-HSA-6798695|reactome:R-HSA-8877330|reactome:R-HSA-977606|rcsb pdb:5FO9|refseq:NP_000564.2|refseq:NP_000642.3	go:"GO:0005509"(calcium ion binding)|go:"GO:0019865"(immunoglobulin binding)|efo:"MONDO:0013343"(see-also)|pubmed:28601358(see-also)|pubmed:22536204(see-also)|intact:EBI-6264878(exp-evidence)|evidence ontology:"ECO:0000353"|complex portal:CPX-1919(complex-primary)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0005576"(extracellular region)|pubmed:20548024(see-also)|pubmed:29449492(see-also)|pubmed:18250442(see-also)|go:"GO:0062167"(complement component C1q complex)|pubmed:31165008(see-also)|pubmed:27914690(see-also)|pubmed:26489954(see-also)	-	-	disease:"Complement component C1q deficiency (C1QD) [MONDO:0013343]: a disorder caused by impaired activation of the complement classical pathway. It generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis."|complex-properties:The complex comprises of six heterotrimeric collagen-like triple helices, formed from triplets of the A, B, and C chains, that associate in their N-terminal half to form a stalk, then diverge to form individual stems, each terminating in a C-terminal globular domain. Each of the six heterotrimeric globular heads or domains is made up of the globular domains from one A, one B, and one C chain, each of which in turn has its own ligand specificity. The six collagen-like stalks appear to be fibril-like and exist in the central region. The collagen-like region and the globular heads can independently interact with a multiplicity of biological structures including pathogen-associated and cell associated molecules, also each of the individual globular head domains is capable of independently interacting with specific ligands. Chains A and B are disulfide-linked whilst the C chain forms a disulfide bond with the C chain of the next strand.     Molecular weight 460 kDa.|curated-complex:"Recognition unit of the classical pathway of complement which associates with the Ca2+ - dependent C1r(2)-C1s(2) tetramer to form C1 (CPX-1920), the first component of the classical complement system. The complex's role in C1 is the recognition of immune complexes, or other molecules, which trigger the classical pathway of the complement system. Independent of complement activation C1q appears to have additional roles in homeostasis and cellular development, superoxide (O2-) production by neutrophils, blood coagulation and neurological synapse pruning."|complex-assembly:Heterooctadecamer	figure legend:1B, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.6x10^-10(molar)	2020/12/18	2021/07/14	rogid:gwNvQZmPMP1PCX8z/svSxkVBZt49606	-	-	false	sufficient binding region:1395-1969|his tag:c-c	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P17927	matrixdb:MULT_82_human	intact:EBI-2807625|ensembl:ENSP00000356018|ensembl:ENSP00000356020|ensembl:ENSP00000383744|uniprotkb:Q5SR43|uniprotkb:Q9UQV2|uniprotkb:Q5SR45|uniprotkb:Q16745|uniprotkb:Q16744	intact:EBI-6264901|reactome:R-HSA-173579|wwpdb:1PK6|wwpdb:2wnv|wwpdb:2jg8|wwpdb:2jg9|wwpdb:2wnu|reactome:R-HSA-173588	psi-mi:cr1_human(display_long)|uniprotkb:CR1(gene name)|psi-mi:CR1(display_short)|uniprotkb:C3BR(gene name synonym)|uniprotkb:C3b/C4b receptor(gene name synonym)	psi-mi:c1q_human(display_short)|psi-mi:MULT_82_human(display_long)|intact:Complement component C1q complex(complex recommended name)|intact:C1q(complex synonym)|intact:Complement 1q(complex synonym)|intact:C1QA-C1QB-C1QC complex(complex synonym)|intact:"6xC1QA:6xC1QB:6xC1QC"(complex systematic name)	psi-mi:"MI:0107"(surface plasmon resonance)	Jacquet et al. (2017)	pubmed:29563915|imex:IM-29085	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27033314|imex:IM-29085-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	ensembl:ENSG00000203710(gene)|go:"GO:0001855"(complement component C4b binding)|go:"GO:0001861"(complement component C4b receptor activity)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0001971"(negative regulation of activation of membrane attack complex)|go:"GO:0002430"(complement receptor mediated signaling pathway)|go:"GO:0002435"(immune complex clearance by erythrocytes)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004877"(complement component C3b receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005856"(cytoskeleton)|ensembl:ENST00000367051(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000367053(transcript)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|ensembl:ENST00000400960(transcript)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045916"(negative regulation of complement activation)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045957"(negative regulation of complement activation, alternative pathway)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900004"(negative regulation of serine-type endopeptidase activity)|go:"GO:1900005"(positive regulation of serine-type endopeptidase activity)|go:"GO:1900099"(negative regulation of plasma cell differentiation)|go:"GO:1904669"(ATP export)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|rcsb pdb:1GKG|rcsb pdb:1GKN|rcsb pdb:1GOP|rcsb pdb:1PPQ|rcsb pdb:2MCY|rcsb pdb:2MCZ|rcsb pdb:2Q7Z|reactome:R-HSA-6798695|reactome:R-HSA-8877330|reactome:R-HSA-977606|rcsb pdb:5FO9|refseq:NP_000564.2|refseq:NP_000642.3	go:"GO:0005509"(calcium ion binding)|go:"GO:0019865"(immunoglobulin binding)|efo:"MONDO:0013343"(see-also)|pubmed:28601358(see-also)|pubmed:22536204(see-also)|intact:EBI-6264878(exp-evidence)|evidence ontology:"ECO:0000353"|complex portal:CPX-1919(complex-primary)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0005576"(extracellular region)|pubmed:20548024(see-also)|pubmed:29449492(see-also)|pubmed:18250442(see-also)|go:"GO:0062167"(complement component C1q complex)|pubmed:31165008(see-also)|pubmed:27914690(see-also)|pubmed:26489954(see-also)	-	-	disease:"Complement component C1q deficiency (C1QD) [MONDO:0013343]: a disorder caused by impaired activation of the complement classical pathway. It generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis."|complex-properties:The complex comprises of six heterotrimeric collagen-like triple helices, formed from triplets of the A, B, and C chains, that associate in their N-terminal half to form a stalk, then diverge to form individual stems, each terminating in a C-terminal globular domain. Each of the six heterotrimeric globular heads or domains is made up of the globular domains from one A, one B, and one C chain, each of which in turn has its own ligand specificity. The six collagen-like stalks appear to be fibril-like and exist in the central region. The collagen-like region and the globular heads can independently interact with a multiplicity of biological structures including pathogen-associated and cell associated molecules, also each of the individual globular head domains is capable of independently interacting with specific ligands. Chains A and B are disulfide-linked whilst the C chain forms a disulfide bond with the C chain of the next strand.     Molecular weight 460 kDa.|curated-complex:"Recognition unit of the classical pathway of complement which associates with the Ca2+ - dependent C1r(2)-C1s(2) tetramer to form C1 (CPX-1920), the first component of the classical complement system. The complex's role in C1 is the recognition of immune complexes, or other molecules, which trigger the classical pathway of the complement system. Independent of complement activation C1q appears to have additional roles in homeostasis and cellular development, superoxide (O2-) production by neutrophils, blood coagulation and neurological synapse pruning."|complex-assembly:Heterooctadecamer	figure legend:4A,5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.9x10^-10(molar)	2020/12/18	2021/07/14	rogid:gwNvQZmPMP1PCX8z/svSxkVBZt49606	-	-	false	sufficient binding region:1517..1517-1648..1648|his tag:c-c	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P17927	uniprotkb:P11226	intact:EBI-2807625|ensembl:ENSP00000356018|ensembl:ENSP00000356020|ensembl:ENSP00000383744|uniprotkb:Q5SR43|uniprotkb:Q9UQV2|uniprotkb:Q5SR45|uniprotkb:Q16745|uniprotkb:Q16744	intact:EBI-5325353|ensembl:ENSP00000363079|ensembl:ENSP00000502615|ensembl:ENSP00000502789|uniprotkb:Q4VB12|uniprotkb:Q4VB13|uniprotkb:Q86SI4|uniprotkb:Q96KE4|uniprotkb:Q96TF7|uniprotkb:Q96TF8|uniprotkb:Q96TF9|uniprotkb:Q4VB14|uniprotkb:Q5SQS3	psi-mi:cr1_human(display_long)|uniprotkb:CR1(gene name)|psi-mi:CR1(display_short)|uniprotkb:C3BR(gene name synonym)|uniprotkb:C3b/C4b receptor(gene name synonym)	psi-mi:mbl2_human(display_long)|uniprotkb:MBL2(gene name)|psi-mi:MBL2(display_short)|uniprotkb:COLEC1(gene name synonym)|uniprotkb:MBL(gene name synonym)|uniprotkb:Collectin-1(gene name synonym)|uniprotkb:MBP1(gene name synonym)|uniprotkb:Mannan-binding protein(gene name synonym)|uniprotkb:Mannose-binding lectin(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Jacquet et al. (2017)	pubmed:29563915|imex:IM-29085	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27033324|imex:IM-29085-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000203710(gene)|go:"GO:0001855"(complement component C4b binding)|go:"GO:0001861"(complement component C4b receptor activity)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0001971"(negative regulation of activation of membrane attack complex)|go:"GO:0002430"(complement receptor mediated signaling pathway)|go:"GO:0002435"(immune complex clearance by erythrocytes)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004877"(complement component C3b receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005856"(cytoskeleton)|ensembl:ENST00000367051(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000367053(transcript)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|ensembl:ENST00000400960(transcript)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045916"(negative regulation of complement activation)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045957"(negative regulation of complement activation, alternative pathway)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900004"(negative regulation of serine-type endopeptidase activity)|go:"GO:1900005"(positive regulation of serine-type endopeptidase activity)|go:"GO:1900099"(negative regulation of plasma cell differentiation)|go:"GO:1904669"(ATP export)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|rcsb pdb:1GKG|rcsb pdb:1GKN|rcsb pdb:1GOP|rcsb pdb:1PPQ|rcsb pdb:2MCY|rcsb pdb:2MCZ|rcsb pdb:2Q7Z|reactome:R-HSA-6798695|reactome:R-HSA-8877330|reactome:R-HSA-977606|rcsb pdb:5FO9|refseq:NP_000564.2|refseq:NP_000642.3	ensembl:ENSG00000165471(gene)|ensembl:ENST00000373968(transcript)|ensembl:ENST00000674931(transcript)|ensembl:ENST00000675947(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008228"(opsonization)|go:"GO:0009986"(cell surface)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048525"(negative regulation of viral process)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001304(C-type lectin)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016186(C-type lectin-like)|refseq:XP_011538118.1|interpro:IPR018378|interpro:IPR033990|interpro:IPR037570|rcsb pdb:1HUP|interpro:IPR016187(C-type lectin fold)|reactome:R-HSA-166662|reactome:R-HSA-166663|refseq:NP_000233.1|refseq:XP_006717924.1|dip:DIP-61381N	-	-	-	figure legend:4B,5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:6.5x10^-10(molar)	2020/12/18	2021/07/14	rogid:gwNvQZmPMP1PCX8z/svSxkVBZt49606	rogid:uo0RM88uw3otObIVnOhUcOfW8yo9606	rigid:lTfTcf19ABoAM9EFegN6riIXxFA	false	sufficient binding region:1517..1517-1648..1648|his tag:c-c	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P17927	matrixdb:MULT_82_human	intact:EBI-2807625|ensembl:ENSP00000356018|ensembl:ENSP00000356020|ensembl:ENSP00000383744|uniprotkb:Q5SR43|uniprotkb:Q9UQV2|uniprotkb:Q5SR45|uniprotkb:Q16745|uniprotkb:Q16744	intact:EBI-6264901|reactome:R-HSA-173579|wwpdb:1PK6|wwpdb:2wnv|wwpdb:2jg8|wwpdb:2jg9|wwpdb:2wnu|reactome:R-HSA-173588	psi-mi:cr1_human(display_long)|uniprotkb:CR1(gene name)|psi-mi:CR1(display_short)|uniprotkb:C3BR(gene name synonym)|uniprotkb:C3b/C4b receptor(gene name synonym)	psi-mi:c1q_human(display_short)|psi-mi:MULT_82_human(display_long)|intact:Complement component C1q complex(complex recommended name)|intact:C1q(complex synonym)|intact:Complement 1q(complex synonym)|intact:C1QA-C1QB-C1QC complex(complex synonym)|intact:"6xC1QA:6xC1QB:6xC1QC"(complex systematic name)	psi-mi:"MI:0107"(surface plasmon resonance)	Jacquet et al. (2017)	pubmed:29563915|imex:IM-29085	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27033490|imex:IM-29085-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	ensembl:ENSG00000203710(gene)|go:"GO:0001855"(complement component C4b binding)|go:"GO:0001861"(complement component C4b receptor activity)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0001971"(negative regulation of activation of membrane attack complex)|go:"GO:0002430"(complement receptor mediated signaling pathway)|go:"GO:0002435"(immune complex clearance by erythrocytes)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004877"(complement component C3b receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005856"(cytoskeleton)|ensembl:ENST00000367051(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000367053(transcript)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|ensembl:ENST00000400960(transcript)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045916"(negative regulation of complement activation)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045957"(negative regulation of complement activation, alternative pathway)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900004"(negative regulation of serine-type endopeptidase activity)|go:"GO:1900005"(positive regulation of serine-type endopeptidase activity)|go:"GO:1900099"(negative regulation of plasma cell differentiation)|go:"GO:1904669"(ATP export)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|rcsb pdb:1GKG|rcsb pdb:1GKN|rcsb pdb:1GOP|rcsb pdb:1PPQ|rcsb pdb:2MCY|rcsb pdb:2MCZ|rcsb pdb:2Q7Z|reactome:R-HSA-6798695|reactome:R-HSA-8877330|reactome:R-HSA-977606|rcsb pdb:5FO9|refseq:NP_000564.2|refseq:NP_000642.3	go:"GO:0005509"(calcium ion binding)|go:"GO:0019865"(immunoglobulin binding)|efo:"MONDO:0013343"(see-also)|pubmed:28601358(see-also)|pubmed:22536204(see-also)|intact:EBI-6264878(exp-evidence)|evidence ontology:"ECO:0000353"|complex portal:CPX-1919(complex-primary)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0005576"(extracellular region)|pubmed:20548024(see-also)|pubmed:29449492(see-also)|pubmed:18250442(see-also)|go:"GO:0062167"(complement component C1q complex)|pubmed:31165008(see-also)|pubmed:27914690(see-also)|pubmed:26489954(see-also)	-	-	disease:"Complement component C1q deficiency (C1QD) [MONDO:0013343]: a disorder caused by impaired activation of the complement classical pathway. It generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis."|complex-properties:The complex comprises of six heterotrimeric collagen-like triple helices, formed from triplets of the A, B, and C chains, that associate in their N-terminal half to form a stalk, then diverge to form individual stems, each terminating in a C-terminal globular domain. Each of the six heterotrimeric globular heads or domains is made up of the globular domains from one A, one B, and one C chain, each of which in turn has its own ligand specificity. The six collagen-like stalks appear to be fibril-like and exist in the central region. The collagen-like region and the globular heads can independently interact with a multiplicity of biological structures including pathogen-associated and cell associated molecules, also each of the individual globular head domains is capable of independently interacting with specific ligands. Chains A and B are disulfide-linked whilst the C chain forms a disulfide bond with the C chain of the next strand.     Molecular weight 460 kDa.|curated-complex:"Recognition unit of the classical pathway of complement which associates with the Ca2+ - dependent C1r(2)-C1s(2) tetramer to form C1 (CPX-1920), the first component of the classical complement system. The complex's role in C1 is the recognition of immune complexes, or other molecules, which trigger the classical pathway of the complement system. Independent of complement activation C1q appears to have additional roles in homeostasis and cellular development, superoxide (O2-) production by neutrophils, blood coagulation and neurological synapse pruning."|complex-assembly:Heterooctadecamer	figure legend:7|comment:"The \"CLF\" usually refers to the term \"collagen-like fragment ( CLF)\"; here,  it is used to refer to \"collagen stalks\" or \"tails\"."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.19x10^-9(molar)	2020/12/18	2021/07/14	rogid:gwNvQZmPMP1PCX8z/svSxkVBZt49606	-	-	false	sufficient binding region:1395-1969|his tag:c-c	sufficient binding region:31..37-109..114	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P17927	uniprotkb:P48740-2	intact:EBI-2807625|ensembl:ENSP00000356018|ensembl:ENSP00000356020|ensembl:ENSP00000383744|uniprotkb:Q5SR43|uniprotkb:Q9UQV2|uniprotkb:Q5SR45|uniprotkb:Q16745|uniprotkb:Q16744	intact:EBI-26435098|ensembl:ENSP00000296280	psi-mi:cr1_human(display_long)|uniprotkb:CR1(gene name)|psi-mi:CR1(display_short)|uniprotkb:C3BR(gene name synonym)|uniprotkb:C3b/C4b receptor(gene name synonym)	psi-mi:p48740-2(display_long)|uniprotkb:Mannose-binding protein-associated serine protease(gene name synonym)|uniprotkb:Ra-reactive factor serine protease p100(gene name synonym)|uniprotkb:Serine protease 5(gene name synonym)|uniprotkb:MASP-3(isoform synonym)|uniprotkb:MASP1(gene name)|psi-mi:MASP1(display_short)|uniprotkb:CRARF(gene name synonym)|uniprotkb:CRARF1(gene name synonym)|uniprotkb:PRSS5(gene name synonym)|uniprotkb:Complement factor MASP-3(gene name synonym)|uniprotkb:Complement-activating component of Ra-reactive factor(gene name synonym)|uniprotkb:Mannose-binding lectin-associated serine protease 1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Jacquet et al. (2017)	pubmed:29563915|imex:IM-29085	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27033504|imex:IM-29085-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000203710(gene)|go:"GO:0001855"(complement component C4b binding)|go:"GO:0001861"(complement component C4b receptor activity)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0001971"(negative regulation of activation of membrane attack complex)|go:"GO:0002430"(complement receptor mediated signaling pathway)|go:"GO:0002435"(immune complex clearance by erythrocytes)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004877"(complement component C3b receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005856"(cytoskeleton)|ensembl:ENST00000367051(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000367053(transcript)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|ensembl:ENST00000400960(transcript)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045916"(negative regulation of complement activation)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045957"(negative regulation of complement activation, alternative pathway)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900004"(negative regulation of serine-type endopeptidase activity)|go:"GO:1900005"(positive regulation of serine-type endopeptidase activity)|go:"GO:1900099"(negative regulation of plasma cell differentiation)|go:"GO:1904669"(ATP export)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|rcsb pdb:1GKG|rcsb pdb:1GKN|rcsb pdb:1GOP|rcsb pdb:1PPQ|rcsb pdb:2MCY|rcsb pdb:2MCZ|rcsb pdb:2Q7Z|reactome:R-HSA-6798695|reactome:R-HSA-8877330|reactome:R-HSA-977606|rcsb pdb:5FO9|refseq:NP_000564.2|refseq:NP_000642.3	ensembl:ENSG00000127241(gene)|ensembl:ENST00000296280(transcript)|intact:EBI-6380536(isoform-parent)	-	-	-	figure legend:7B, Supp. figure 2|comment:"Competition by MASP-3 does not completely abolish C1q binding to CR1. A  C1q protease-binding site mutant (text:LysB61A, LysC58A) or (figure legend:Lys59A,LysB61A, LysC58A)  also reduces binding to CR1 CCP22-30."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2021/07/14	rogid:gwNvQZmPMP1PCX8z/svSxkVBZt49606	rogid:tXsz/6dPTPLuD03oT3LxFm6yDA09606	-	false	sufficient binding region:1395-1969|his tag:c-c	-	1	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P17927	matrixdb:MULT_82_human	intact:EBI-2807625|ensembl:ENSP00000356018|ensembl:ENSP00000356020|ensembl:ENSP00000383744|uniprotkb:Q5SR43|uniprotkb:Q9UQV2|uniprotkb:Q5SR45|uniprotkb:Q16745|uniprotkb:Q16744	intact:EBI-6264901|reactome:R-HSA-173579|wwpdb:1PK6|wwpdb:2wnv|wwpdb:2jg8|wwpdb:2jg9|wwpdb:2wnu|reactome:R-HSA-173588	psi-mi:cr1_human(display_long)|uniprotkb:CR1(gene name)|psi-mi:CR1(display_short)|uniprotkb:C3BR(gene name synonym)|uniprotkb:C3b/C4b receptor(gene name synonym)	psi-mi:c1q_human(display_short)|psi-mi:MULT_82_human(display_long)|intact:Complement component C1q complex(complex recommended name)|intact:C1q(complex synonym)|intact:Complement 1q(complex synonym)|intact:C1QA-C1QB-C1QC complex(complex synonym)|intact:"6xC1QA:6xC1QB:6xC1QC"(complex systematic name)	psi-mi:"MI:0107"(surface plasmon resonance)	Jacquet et al. (2017)	pubmed:29563915|imex:IM-29085	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27033504|imex:IM-29085-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	ensembl:ENSG00000203710(gene)|go:"GO:0001855"(complement component C4b binding)|go:"GO:0001861"(complement component C4b receptor activity)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0001971"(negative regulation of activation of membrane attack complex)|go:"GO:0002430"(complement receptor mediated signaling pathway)|go:"GO:0002435"(immune complex clearance by erythrocytes)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004877"(complement component C3b receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005856"(cytoskeleton)|ensembl:ENST00000367051(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000367053(transcript)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|ensembl:ENST00000400960(transcript)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045916"(negative regulation of complement activation)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045957"(negative regulation of complement activation, alternative pathway)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900004"(negative regulation of serine-type endopeptidase activity)|go:"GO:1900005"(positive regulation of serine-type endopeptidase activity)|go:"GO:1900099"(negative regulation of plasma cell differentiation)|go:"GO:1904669"(ATP export)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|rcsb pdb:1GKG|rcsb pdb:1GKN|rcsb pdb:1GOP|rcsb pdb:1PPQ|rcsb pdb:2MCY|rcsb pdb:2MCZ|rcsb pdb:2Q7Z|reactome:R-HSA-6798695|reactome:R-HSA-8877330|reactome:R-HSA-977606|rcsb pdb:5FO9|refseq:NP_000564.2|refseq:NP_000642.3	go:"GO:0005509"(calcium ion binding)|go:"GO:0019865"(immunoglobulin binding)|efo:"MONDO:0013343"(see-also)|pubmed:28601358(see-also)|pubmed:22536204(see-also)|intact:EBI-6264878(exp-evidence)|evidence ontology:"ECO:0000353"|complex portal:CPX-1919(complex-primary)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0005576"(extracellular region)|pubmed:20548024(see-also)|pubmed:29449492(see-also)|pubmed:18250442(see-also)|go:"GO:0062167"(complement component C1q complex)|pubmed:31165008(see-also)|pubmed:27914690(see-also)|pubmed:26489954(see-also)	-	-	disease:"Complement component C1q deficiency (C1QD) [MONDO:0013343]: a disorder caused by impaired activation of the complement classical pathway. It generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis."|complex-properties:The complex comprises of six heterotrimeric collagen-like triple helices, formed from triplets of the A, B, and C chains, that associate in their N-terminal half to form a stalk, then diverge to form individual stems, each terminating in a C-terminal globular domain. Each of the six heterotrimeric globular heads or domains is made up of the globular domains from one A, one B, and one C chain, each of which in turn has its own ligand specificity. The six collagen-like stalks appear to be fibril-like and exist in the central region. The collagen-like region and the globular heads can independently interact with a multiplicity of biological structures including pathogen-associated and cell associated molecules, also each of the individual globular head domains is capable of independently interacting with specific ligands. Chains A and B are disulfide-linked whilst the C chain forms a disulfide bond with the C chain of the next strand.     Molecular weight 460 kDa.|curated-complex:"Recognition unit of the classical pathway of complement which associates with the Ca2+ - dependent C1r(2)-C1s(2) tetramer to form C1 (CPX-1920), the first component of the classical complement system. The complex's role in C1 is the recognition of immune complexes, or other molecules, which trigger the classical pathway of the complement system. Independent of complement activation C1q appears to have additional roles in homeostasis and cellular development, superoxide (O2-) production by neutrophils, blood coagulation and neurological synapse pruning."|complex-assembly:Heterooctadecamer	figure legend:7B, Supp. figure 2|comment:"Competition by MASP-3 does not completely abolish C1q binding to CR1. A  C1q protease-binding site mutant (text:LysB61A, LysC58A) or (figure legend:Lys59A,LysB61A, LysC58A)  also reduces binding to CR1 CCP22-30."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2021/07/14	rogid:gwNvQZmPMP1PCX8z/svSxkVBZt49606	-	-	false	sufficient binding region:1395-1969|his tag:c-c	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P17927	matrixdb:MULT_82_human	intact:EBI-2807625|ensembl:ENSP00000356018|ensembl:ENSP00000356020|ensembl:ENSP00000383744|uniprotkb:Q5SR43|uniprotkb:Q9UQV2|uniprotkb:Q5SR45|uniprotkb:Q16745|uniprotkb:Q16744	intact:EBI-6264901|reactome:R-HSA-173579|wwpdb:1PK6|wwpdb:2wnv|wwpdb:2jg8|wwpdb:2jg9|wwpdb:2wnu|reactome:R-HSA-173588	psi-mi:cr1_human(display_long)|uniprotkb:CR1(gene name)|psi-mi:CR1(display_short)|uniprotkb:C3BR(gene name synonym)|uniprotkb:C3b/C4b receptor(gene name synonym)	psi-mi:c1q_human(display_short)|psi-mi:MULT_82_human(display_long)|intact:Complement component C1q complex(complex recommended name)|intact:C1q(complex synonym)|intact:Complement 1q(complex synonym)|intact:C1QA-C1QB-C1QC complex(complex synonym)|intact:"6xC1QA:6xC1QB:6xC1QC"(complex systematic name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Jacquet et al. (2017)	pubmed:29563915|imex:IM-29085	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27033242|imex:IM-29085-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	ensembl:ENSG00000203710(gene)|go:"GO:0001855"(complement component C4b binding)|go:"GO:0001861"(complement component C4b receptor activity)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0001971"(negative regulation of activation of membrane attack complex)|go:"GO:0002430"(complement receptor mediated signaling pathway)|go:"GO:0002435"(immune complex clearance by erythrocytes)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004877"(complement component C3b receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005856"(cytoskeleton)|ensembl:ENST00000367051(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000367053(transcript)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|ensembl:ENST00000400960(transcript)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045916"(negative regulation of complement activation)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045957"(negative regulation of complement activation, alternative pathway)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900004"(negative regulation of serine-type endopeptidase activity)|go:"GO:1900005"(positive regulation of serine-type endopeptidase activity)|go:"GO:1900099"(negative regulation of plasma cell differentiation)|go:"GO:1904669"(ATP export)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|rcsb pdb:1GKG|rcsb pdb:1GKN|rcsb pdb:1GOP|rcsb pdb:1PPQ|rcsb pdb:2MCY|rcsb pdb:2MCZ|rcsb pdb:2Q7Z|reactome:R-HSA-6798695|reactome:R-HSA-8877330|reactome:R-HSA-977606|rcsb pdb:5FO9|refseq:NP_000564.2|refseq:NP_000642.3	go:"GO:0005509"(calcium ion binding)|go:"GO:0019865"(immunoglobulin binding)|efo:"MONDO:0013343"(see-also)|pubmed:28601358(see-also)|pubmed:22536204(see-also)|intact:EBI-6264878(exp-evidence)|evidence ontology:"ECO:0000353"|complex portal:CPX-1919(complex-primary)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0005576"(extracellular region)|pubmed:20548024(see-also)|pubmed:29449492(see-also)|pubmed:18250442(see-also)|go:"GO:0062167"(complement component C1q complex)|pubmed:31165008(see-also)|pubmed:27914690(see-also)|pubmed:26489954(see-also)	-	-	disease:"Complement component C1q deficiency (C1QD) [MONDO:0013343]: a disorder caused by impaired activation of the complement classical pathway. It generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis."|complex-properties:The complex comprises of six heterotrimeric collagen-like triple helices, formed from triplets of the A, B, and C chains, that associate in their N-terminal half to form a stalk, then diverge to form individual stems, each terminating in a C-terminal globular domain. Each of the six heterotrimeric globular heads or domains is made up of the globular domains from one A, one B, and one C chain, each of which in turn has its own ligand specificity. The six collagen-like stalks appear to be fibril-like and exist in the central region. The collagen-like region and the globular heads can independently interact with a multiplicity of biological structures including pathogen-associated and cell associated molecules, also each of the individual globular head domains is capable of independently interacting with specific ligands. Chains A and B are disulfide-linked whilst the C chain forms a disulfide bond with the C chain of the next strand.     Molecular weight 460 kDa.|curated-complex:"Recognition unit of the classical pathway of complement which associates with the Ca2+ - dependent C1r(2)-C1s(2) tetramer to form C1 (CPX-1920), the first component of the classical complement system. The complex's role in C1 is the recognition of immune complexes, or other molecules, which trigger the classical pathway of the complement system. Independent of complement activation C1q appears to have additional roles in homeostasis and cellular development, superoxide (O2-) production by neutrophils, blood coagulation and neurological synapse pruning."|complex-assembly:Heterooctadecamer	figure legend:2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2021/07/14	rogid:gwNvQZmPMP1PCX8z/svSxkVBZt49606	-	-	false	sufficient binding region:1395-1648..1648|his tag:c-c	-	1	1	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)