#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9U3L0	uniprotkb:Q95R14	intact:EBI-2415382|ensemblmetazoa:D1081.9.1	intact:EBI-2415375|ensemblmetazoa:F55A12.10.1	psi-mi:zhp2_caeel(display_long)|uniprotkb:zhp-2(gene name)|psi-mi:zhp-2(display_short)|uniprotkb:D1081.9(orf name)	psi-mi:zhp1_caeel(display_long)|uniprotkb:zhp-1(gene name)|psi-mi:zhp-1(display_short)|uniprotkb:F55A12.10(orf name)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2018)	pubmed:29521627|imex:IM-28179	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25619367|imex:IM-28179-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_492301.1|wormbase:D1081.9|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR042123|ensemblmetazoa:D1081.9.1(transcript)|ensemblmetazoa:WBGene00008387(gene)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0046872"(metal ion binding)	refseq:NP_491578.1|wormbase:F55A12.10|interpro:IPR042123|ensemblmetazoa:F55A12.10.1(transcript)|ensemblmetazoa:WBGene00018867(gene)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0046872"(metal ion binding)	-	-	-	figure legend:Fig 2I, Supp Fig.2E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/05/22	2020/05/22	rogid:tUXw3AKwfIImNdGJ2cVgCWrBt5I6239	rogid:R/afuSj2dMRiPBRiCgRwPxs0pW46239	rigid:/q3II2or/zEtUH/XAeIbHTlLnDk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9U3L0	uniprotkb:Q95R14	intact:EBI-2415382|ensemblmetazoa:D1081.9.1	intact:EBI-2415375|ensemblmetazoa:F55A12.10.1	psi-mi:zhp2_caeel(display_long)|uniprotkb:zhp-2(gene name)|psi-mi:zhp-2(display_short)|uniprotkb:D1081.9(orf name)	psi-mi:zhp1_caeel(display_long)|uniprotkb:zhp-1(gene name)|psi-mi:zhp-1(display_short)|uniprotkb:F55A12.10(orf name)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2018)	pubmed:29521627|imex:IM-28179	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25619371|imex:IM-28179-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_492301.1|wormbase:D1081.9|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR042123|ensemblmetazoa:D1081.9.1(transcript)|ensemblmetazoa:WBGene00008387(gene)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0046872"(metal ion binding)	refseq:NP_491578.1|wormbase:F55A12.10|interpro:IPR042123|ensemblmetazoa:F55A12.10.1(transcript)|ensemblmetazoa:WBGene00018867(gene)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0046872"(metal ion binding)	-	-	-	figure legend:Fig 2I, Supp Fig.2E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/05/22	2020/05/22	rogid:tUXw3AKwfIImNdGJ2cVgCWrBt5I6239	rogid:R/afuSj2dMRiPBRiCgRwPxs0pW46239	rigid:/q3II2or/zEtUH/XAeIbHTlLnDk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:C6KRL6	uniprotkb:Q8MYP1	intact:EBI-25597963|ensemblmetazoa:K02B12.8b.1|uniprotkb:P90905	intact:EBI-2920397|ensemblmetazoa:Y39B6A.16.1	psi-mi:zhp3_caeel(display_long)|uniprotkb:zhp-3(gene name)|psi-mi:zhp-3(display_short)|uniprotkb:Zip3-homologous protein(gene name synonym)|uniprotkb:K02B12.8(orf name)	psi-mi:zhp4_caeel(display_long)|uniprotkb:zhp-4(gene name)|psi-mi:zhp-4(display_short)|uniprotkb:Y39B6A.16(orf name)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2018)	pubmed:29521627|imex:IM-28179	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25619375|imex:IM-28179-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:K02B12.8b.1(transcript)|ensemblmetazoa:WBGene00006976(gene)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0046872"(metal ion binding)|go:"GO:0070194"(synaptonemal complex disassembly)|refseq:NP_001250802.1|wormbase:K02B12.8b|interpro:IPR042123|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR017907|wormbase:K02B12.8a|refseq:NP_001250801.1	ensemblmetazoa:WBGene00012678(gene)|ensemblmetazoa:Y39B6A.16.1(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0046872"(metal ion binding)|refseq:NP_741682.1|wormbase:Y39B6A.16|interpro:IPR042123	-	-	-	figure legend:Fig 2I, Supp Fig.2E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/05/22	2020/05/22	rogid:wRzovoB3Izh3HQBqwayutQjOH5c6239	rogid:65GgqBQyCuBSmAKgjX9NSdOqRjM6239	rigid:7/HY1i4CPnyaV16vz+VxPro3khQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:C6KRL6	uniprotkb:Q8MYP1	intact:EBI-25597963|ensemblmetazoa:K02B12.8b.1|uniprotkb:P90905	intact:EBI-2920397|ensemblmetazoa:Y39B6A.16.1	psi-mi:zhp3_caeel(display_long)|uniprotkb:zhp-3(gene name)|psi-mi:zhp-3(display_short)|uniprotkb:Zip3-homologous protein(gene name synonym)|uniprotkb:K02B12.8(orf name)	psi-mi:zhp4_caeel(display_long)|uniprotkb:zhp-4(gene name)|psi-mi:zhp-4(display_short)|uniprotkb:Y39B6A.16(orf name)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2018)	pubmed:29521627|imex:IM-28179	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25619384|imex:IM-28179-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:K02B12.8b.1(transcript)|ensemblmetazoa:WBGene00006976(gene)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0046872"(metal ion binding)|go:"GO:0070194"(synaptonemal complex disassembly)|refseq:NP_001250802.1|wormbase:K02B12.8b|interpro:IPR042123|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR017907|wormbase:K02B12.8a|refseq:NP_001250801.1	ensemblmetazoa:WBGene00012678(gene)|ensemblmetazoa:Y39B6A.16.1(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0046872"(metal ion binding)|refseq:NP_741682.1|wormbase:Y39B6A.16|interpro:IPR042123	-	-	-	figure legend:Fig 2I, Supp Fig.2E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/05/22	2020/05/22	rogid:wRzovoB3Izh3HQBqwayutQjOH5c6239	rogid:65GgqBQyCuBSmAKgjX9NSdOqRjM6239	rigid:7/HY1i4CPnyaV16vz+VxPro3khQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06400	uniprotkb:Q01094	intact:EBI-491274|uniprotkb:P78499|uniprotkb:Q5VW46|uniprotkb:Q8IZL4|uniprotkb:A8K5E3|ensembl:ENSP00000267163	intact:EBI-448924|uniprotkb:Q13143|uniprotkb:Q92768|ensembl:ENSP00000345571	psi-mi:rb_human(display_long)|uniprotkb:pRb(gene name synonym)|uniprotkb:pp110(gene name synonym)|uniprotkb:p105-Rb(gene name synonym)|uniprotkb:RB1(gene name)|psi-mi:RB1(display_short)|uniprotkb:p110-RB1(gene name synonym)	psi-mi:e2f1_human(display_long)|uniprotkb:Retinoblastoma-associated protein 1(gene name synonym)|uniprotkb:Retinoblastoma-binding protein 3(gene name synonym)|uniprotkb:PBR3(gene name synonym)|uniprotkb:E2F1(gene name)|psi-mi:E2F1(display_short)|uniprotkb:RBBP3(gene name synonym)|uniprotkb:pRB-binding protein E2F-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2018)	pubmed:29521627|imex:IM-28179	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25619388|imex:IM-28179-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:1903055"(positive regulation of extracellular matrix organization)|refseq:NP_000312.2|go:"GO:1904028"(positive regulation of collagen fibril organization)|go:"GO:1904761"(negative regulation of myofibroblast differentiation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR002719(Retinoblastoma-associated protein, B-box)|interpro:IPR002720(Retinoblastoma-associated protein, A-box)|interpro:IPR013763(Cyclin-related)|interpro:IPR015030(Rb C-terminal)|interpro:IPR024599|interpro:IPR028309|interpro:IPR036915|mint:P06400|rcsb pdb:1AD6|rcsb pdb:1GH6|rcsb pdb:1GUX|rcsb pdb:1H25|rcsb pdb:1N4M|rcsb pdb:1O9K|rcsb pdb:1PJM|rcsb pdb:2AZE|rcsb pdb:2QDJ|rcsb pdb:2R7G|rcsb pdb:3N5U|rcsb pdb:3POM|rcsb pdb:4CRI|rcsb pdb:4ELJ|rcsb pdb:4ELL|reactome:R-HSA-113501|reactome:R-HSA-174178|reactome:R-HSA-2299718|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69656|reactome:R-HSA-8940973|reactome:R-HSA-9661069|reactome:R-HSA-9661070|reactome:R-HSA-9682706|reactome:R-HSA-9687136|reactome:R-HSA-9694686|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016605"(PML body)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0019900"(kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042551"(neuron maturation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043353"(enucleate erythrocyte differentiation)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043550"(regulation of lipid kinase activity)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048565"(digestive tract development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071922"(regulation of cohesin loading)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0090230"(regulation of centromere complex assembly)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|ensembl:ENSG00000139687(gene)|ensembl:ENST00000267163(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-582N	refseq:NP_005216.1|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030900"(forebrain development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043276"(anoikis)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048255"(mRNA stabilization)|ensembl:ENSG00000101412(gene)|ensembl:ENST00000343380(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR015633(E2F Family)|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-6804116|reactome:R-HSA-68689|reactome:R-HSA-68911|reactome:R-HSA-69202|reactome:R-HSA-69205|reactome:R-HSA-69231|interpro:IPR032198|interpro:IPR036388|interpro:IPR036390|interpro:IPR037241|mint:Q01094|rcsb pdb:1H24|rcsb pdb:1O9K|rcsb pdb:2AZE|rcsb pdb:5M9N|rcsb pdb:5M9O|rcsb pdb:6G0P|rcsb pdb:6ULS|reactome:R-HSA-111448|reactome:R-HSA-113501|reactome:R-HSA-1362277|reactome:R-HSA-1362300|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-69656|reactome:R-HSA-8953750|reactome:R-HSA-9616222|reactome:R-HSA-9661069|dip:DIP-24227N	-	-	-	figure legend:Fig.2I|comment:Weak interaction|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/05/22	2020/05/22	rogid:xidCNX96KlQzu160polvT61k4Zw9606	rogid:vPNenpmxyXpHjMzUID54cwMFk+Y9606	rigid:1ICFIJi6abR0D7qDhA+DbWTsIjM	false	sufficient binding region:302-928	sufficient binding region:342-437	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P12841	uniprotkb:P05627	intact:EBI-8590661|ensembl:ENSRNOP00000010712|intact:MINT-220035|uniprotkb:Q4FDN1	intact:EBI-764369|ensembl:ENSMUSP00000102711	psi-mi:fos_rat(display_long)|uniprotkb:Fos(gene name)|psi-mi:Fos(display_short)|uniprotkb:Cellular oncogene fos(gene name synonym)	psi-mi:jun_mouse(display_long)|uniprotkb:Activator protein 1(gene name synonym)|uniprotkb:Proto-oncogene c-Jun(gene name synonym)|uniprotkb:V-jun avian sarcoma virus 17 oncogene homolog(gene name synonym)|uniprotkb:AH119(gene name synonym)|uniprotkb:Jun(gene name)|psi-mi:Jun(display_short)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2018)	pubmed:29521627|imex:IM-28179	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25619397|imex:IM-28179-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOT00000010712(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0009409"(response to cold)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009629"(response to gravity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0030431"(sleep)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032570"(response to progesterone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034097"(response to cytokine)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035976"(transcription factor AP-1 complex)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051591"(response to cAMP)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000837(Fos transforming protein)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029816|mint:P12841|reactome:R-RNO-2559580|reactome:R-RNO-2871796|reactome:R-RNO-450341|ensembl:ENSRNOG00000008015(gene)|dip:DIP-6001N|rgd:2626|refseq:NP_071533.1	refseq:NP_034721.1|dip:DIP-1068N|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0007612"(learning)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0009987"(cellular process)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0031103"(axon regeneration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034097"(response to cytokine)|go:"GO:0003682"(chromatin binding)|ensembl:ENSMUSG00000052684(gene)|ensembl:ENSMUST00000107094(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001889"(liver development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0035976"(transcription factor AP-1 complex)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035026"(leading edge cell differentiation)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051365"(cellular response to potassium ion starvation)|go:"GO:0051591"(response to cAMP)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071837"(HMG box domain binding)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|interpro:IPR002112(Transcription factor Jun)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR005643(Jun-like transcription factor)|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR015558(c-Jun Transcription Factor)|mint:P05627|reactome:R-MMU-2559580|reactome:R-MMU-2871796|reactome:R-MMU-450341|reactome:R-MMU-9018519|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071277"(cellular response to calcium ion)	-	comment:mint|function:Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation	-	figure legend:Fig.2I|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/05/22	2020/05/22	rogid:Z2Uzy+YrqRF+K+uW2F98AEkHLjw10116	rogid:uEOUeeaXEsnmO+XuqF1WfIF96go10090	rigid:po3R2Fi4u8Fujf57MRGkbxo59wI	false	sufficient binding region:132-211	sufficient binding region:250-325	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q24318	uniprotkb:Q27368	intact:EBI-530830|uniprotkb:O17472|uniprotkb:O44080|uniprotkb:Q86PE0|uniprotkb:Q8ML56|uniprotkb:Q9V6M0|uniprotkb:B8A3X4|ensemblmetazoa:FBpp0086853	intact:EBI-108384|uniprotkb:O77035|uniprotkb:Q5U0Z6|ensemblmetazoa:FBpp0083516|ensemblmetazoa:FBpp0083517|ensemblmetazoa:FBpp0083518|ensemblmetazoa:FBpp0311985	psi-mi:tfdp_drome(display_long)|uniprotkb:Dp(gene name)|psi-mi:Dp(display_short)|uniprotkb:CG4654(orf name)	psi-mi:e2f1_drome(display_long)|uniprotkb:E2f1(gene name)|psi-mi:E2f1(display_short)|uniprotkb:E2f(gene name synonym)|uniprotkb:dE2F(gene name synonym)|uniprotkb:CG6376(orf name)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2018)	pubmed:29521627|imex:IM-28179	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25754387|imex:IM-28179-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_477039.1|refseq:NP_725267.1|flybase:FBgn0011763|ensemblmetazoa:FBgn0011763(gene)|ensemblmetazoa:FBtr0087740(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007113"(endomitotic cell cycle)|go:"GO:0007307"(eggshell chorion gene amplification)|go:"GO:0008069"(dorsal/ventral axis specification, ovarian follicular epithelium)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0031523"(Myb complex)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0045850"(positive regulation of nurse cell apoptotic process)|go:"GO:0048477"(oogenesis)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR014889(Transcription factor DP, C-terminal)|interpro:IPR015648(Transcription factor DP)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037241|interpro:IPR038168|reactome:R-DME-1538133|reactome:R-DME-2173796|reactome:R-DME-69231|reactome:R-DME-8953750|go:"GO:0045476"(nurse cell apoptotic process)	refseq:NP_524437.2|refseq:NP_732646.1|refseq:NP_732647.1|flybase:FBgn0011766|refseq:NP_001287455.1|dip:DIP-21076N|ensemblmetazoa:FBgn0011766(gene)|ensemblmetazoa:FBtr0084117(transcript)|ensemblmetazoa:FBtr0084118(transcript)|ensemblmetazoa:FBtr0084119(transcript)|ensemblmetazoa:FBtr0346157(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007307"(eggshell chorion gene amplification)|go:"GO:0007419"(ventral cord development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032877"(positive regulation of DNA endoreduplication)|go:"GO:0035167"(larval lymph gland hemopoiesis)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0035206"(regulation of hemocyte proliferation)|go:"GO:0042023"(DNA endoreduplication)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045850"(positive regulation of nurse cell apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1900117"(regulation of execution phase of apoptosis)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR015633(E2F Family)|interpro:IPR032198|interpro:IPR036388|interpro:IPR036390|interpro:IPR037241|reactome:R-DME-68689|reactome:R-DME-68911|reactome:R-DME-8953750	-	-	-	figure legend:Fig.2I|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/05/22	2020/07/13	rogid:uM/3Ia2BNTAfz62QpZVgh+S63NM7227	rogid:iuWAVrB7ugwrZPPrJbYLNhkvS2A7227	rigid:DzIzlVJuKIQ/Bk5XObytNz0cZaU	false	sufficient binding region:1-377	sufficient binding region:225-433	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)