#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P14780	uniprotkb:Q9ZFS6	intact:EBI-1382326|uniprotkb:Q3LR70|uniprotkb:Q8N725|uniprotkb:Q9H4Z1|uniprotkb:B2R7V9|uniprotkb:Q9UCJ9|uniprotkb:Q9UCL1|uniprotkb:Q9UDK2|ensembl:ENSP00000361405	intact:EBI-26361542|ensemblbacteria:CXO06451|ensemblbacteria:SPZ97045	psi-mi:mmp9_human(display_long)|uniprotkb:MMP9(gene name)|psi-mi:MMP9(display_short)|uniprotkb:CLG4B(gene name synonym)|uniprotkb:92 kDa type IV collagenase(gene name synonym)|uniprotkb:92 kDa gelatinase(gene name synonym)|uniprotkb:Gelatinase B(gene name synonym)	psi-mi:q9zfs6_staau(display_long)|uniprotkb:set3(gene name)|psi-mi:set3(display_short)|uniprotkb:NCTC7878_00467(orf name)|uniprotkb:FPP26_02070(orf name)	psi-mi:"MI:0096"(pull down)	Kurisaka et al. (2018)	imex:IM-28387|pubmed:29328525	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:1280(staau)|taxid:1280(Staphylococcus aureus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26361569|imex:IM-28387-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004985.2|dip:DIP-29518N|ensembl:ENSG00000100985(gene)|ensembl:ENST00000372330(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006508"(proteolysis)|go:"GO:0007566"(embryo implantation)|go:"GO:0008233"(peptidase activity)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000697"(negative regulation of epithelial cell differentiation involved in kidney development)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001258"(negative regulation of cation channel activity)|go:"GO:2001268"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR000585(Hemopexin)|interpro:IPR001818(Peptidase M10A and M12B, matrixin and adamalysin)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR013806(Kringle-like fold)|interpro:IPR018486|interpro:IPR018487|interpro:IPR021158|interpro:IPR021190|interpro:IPR024079|interpro:IPR028688|interpro:IPR033739|go:"GO:1900122"(positive regulation of receptor binding)|interpro:IPR036365|interpro:IPR036375|interpro:IPR036943|mint:P14780|rcsb pdb:1GKC|rcsb pdb:1GKD|rcsb pdb:1ITV|rcsb pdb:1L6J|rcsb pdb:1LKG|rcsb pdb:2OVX|rcsb pdb:2OVZ|rcsb pdb:2OW0|rcsb pdb:2OW1|rcsb pdb:2OW2|rcsb pdb:4H1Q|rcsb pdb:4H2E|rcsb pdb:4H3X|rcsb pdb:4H82|rcsb pdb:4HMA|rcsb pdb:4JIJ|rcsb pdb:4JQG|rcsb pdb:4WZV|rcsb pdb:4XCT|rcsb pdb:5CUH|rcsb pdb:5I12|rcsb pdb:5TH6|rcsb pdb:5TH9|rcsb pdb:5UE3|rcsb pdb:5UE4|rcsb pdb:6ESM|reactome:R-HSA-1433557|reactome:R-HSA-1442490|reactome:R-HSA-1474228|reactome:R-HSA-1592389|reactome:R-HSA-2022090|reactome:R-HSA-3928665|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-9009391	ensemblbacteria:CXO06451(transcript)|ensemblbacteria:ERS072840_02174(gene)|ensemblbacteria:NCTC7878_00467(gene)|ensemblbacteria:SPZ97045(transcript)|go:"GO:0005576"(extracellular region)|refseq:WP_000784258.1|rcsb pdb:1M4V|rcsb pdb:2R61|rcsb pdb:2Z8L|interpro:IPR008992(Enterotoxin, bacterial)|interpro:IPR015282(Staphylococcal toxin DUF1954)|interpro:IPR006126(Staphylococcal enterotoxin/Streptococcal pyrogenic exotoxin, conserved site)|interpro:IPR008375(Staphylococcus aureus exotoxin)|interpro:IPR016091(Superantigen toxin, C-terminal, Staphylococcal/Streptococcal)|interpro:IPR013307(Superantigen, bacterial)|interpro:IPR006123(Toxin, beta-grasp, Staphylococcal/Streptococcal)	-	-	-	figure legend:f2a f4b f5 f7b|comment:"he pull‐down assay using GST‐SSL5‐agarose in combination with zymography or western blotting showed that immobilized SSL5 bound to MMP‐9 derived from CHO‐K1 cells but did not bind to MMP‐9 from Lec2 mutant cells (Fig. 5)."|comment:"Pull‐down assay clearly showed that GST‐SSL5‐agarose failed to coprecipitate neuraminidase‐treated MMP‐9 (Fig. 4b)."|comment:"The pull‐down assay with GST‐SSL5‐agarose showed that MMP‐9 from benzyl‐GalNAc‐treated THP‐1 cells possessed weaker reactivity with GST‐SSL5 (Fig. 7b), suggesting that O‐gycans of MMP‐9 play a crucial role in its binding to GST‐SSL5."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/09/29	2020/09/29	rogid:0PnzH1KPp4SKRWfRGotPA2eSHZk9606	rogid:4DgBnyO+rEHxGvitZFwkdvOV1xA1280	rigid:AcMf2qR/4dpoQy/nbUeG3xwGTOs	false	-	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P14780	uniprotkb:Q9ZFS6	intact:EBI-1382326|uniprotkb:Q3LR70|uniprotkb:Q8N725|uniprotkb:Q9H4Z1|uniprotkb:B2R7V9|uniprotkb:Q9UCJ9|uniprotkb:Q9UCL1|uniprotkb:Q9UDK2|ensembl:ENSP00000361405	intact:EBI-26361542|ensemblbacteria:CXO06451|ensemblbacteria:SPZ97045	psi-mi:mmp9_human(display_long)|uniprotkb:MMP9(gene name)|psi-mi:MMP9(display_short)|uniprotkb:CLG4B(gene name synonym)|uniprotkb:92 kDa type IV collagenase(gene name synonym)|uniprotkb:92 kDa gelatinase(gene name synonym)|uniprotkb:Gelatinase B(gene name synonym)	psi-mi:q9zfs6_staau(display_long)|uniprotkb:set3(gene name)|psi-mi:set3(display_short)|uniprotkb:NCTC7878_00467(orf name)|uniprotkb:FPP26_02070(orf name)	psi-mi:"MI:0096"(pull down)	Kurisaka et al. (2018)	imex:IM-28387|pubmed:29328525	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:1280(staau)|taxid:1280(Staphylococcus aureus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-26361608|imex:IM-28387-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004985.2|dip:DIP-29518N|ensembl:ENSG00000100985(gene)|ensembl:ENST00000372330(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006508"(proteolysis)|go:"GO:0007566"(embryo implantation)|go:"GO:0008233"(peptidase activity)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000697"(negative regulation of epithelial cell differentiation involved in kidney development)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001258"(negative regulation of cation channel activity)|go:"GO:2001268"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR000585(Hemopexin)|interpro:IPR001818(Peptidase M10A and M12B, matrixin and adamalysin)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR013806(Kringle-like fold)|interpro:IPR018486|interpro:IPR018487|interpro:IPR021158|interpro:IPR021190|interpro:IPR024079|interpro:IPR028688|interpro:IPR033739|go:"GO:1900122"(positive regulation of receptor binding)|interpro:IPR036365|interpro:IPR036375|interpro:IPR036943|mint:P14780|rcsb pdb:1GKC|rcsb pdb:1GKD|rcsb pdb:1ITV|rcsb pdb:1L6J|rcsb pdb:1LKG|rcsb pdb:2OVX|rcsb pdb:2OVZ|rcsb pdb:2OW0|rcsb pdb:2OW1|rcsb pdb:2OW2|rcsb pdb:4H1Q|rcsb pdb:4H2E|rcsb pdb:4H3X|rcsb pdb:4H82|rcsb pdb:4HMA|rcsb pdb:4JIJ|rcsb pdb:4JQG|rcsb pdb:4WZV|rcsb pdb:4XCT|rcsb pdb:5CUH|rcsb pdb:5I12|rcsb pdb:5TH6|rcsb pdb:5TH9|rcsb pdb:5UE3|rcsb pdb:5UE4|rcsb pdb:6ESM|reactome:R-HSA-1433557|reactome:R-HSA-1442490|reactome:R-HSA-1474228|reactome:R-HSA-1592389|reactome:R-HSA-2022090|reactome:R-HSA-3928665|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-9009391	ensemblbacteria:CXO06451(transcript)|ensemblbacteria:ERS072840_02174(gene)|ensemblbacteria:NCTC7878_00467(gene)|ensemblbacteria:SPZ97045(transcript)|go:"GO:0005576"(extracellular region)|refseq:WP_000784258.1|rcsb pdb:1M4V|rcsb pdb:2R61|rcsb pdb:2Z8L|interpro:IPR008992(Enterotoxin, bacterial)|interpro:IPR015282(Staphylococcal toxin DUF1954)|interpro:IPR006126(Staphylococcal enterotoxin/Streptococcal pyrogenic exotoxin, conserved site)|interpro:IPR008375(Staphylococcus aureus exotoxin)|interpro:IPR016091(Superantigen toxin, C-terminal, Staphylococcal/Streptococcal)|interpro:IPR013307(Superantigen, bacterial)|interpro:IPR006123(Toxin, beta-grasp, Staphylococcal/Streptococcal)	-	-	-	figure legend:f6b|comment:"The pull‐down assay showed that both the intact and de‐N‐glycosylated MMP‐9 were similarly coprecipitated with GST‐SSL5‐agarose (Fig. 6b)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/09/29	2020/09/29	rogid:0PnzH1KPp4SKRWfRGotPA2eSHZk9606	rogid:4DgBnyO+rEHxGvitZFwkdvOV1xA1280	rigid:AcMf2qR/4dpoQy/nbUeG3xwGTOs	false	-	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)