#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P0C6X7-PRO_0000037320 uniprotkb:P0C6X7-PRO_0000037317 intact:EBI-25487328 intact:EBI-25487277 psi-mi:p0c6x7-pro_0000037320(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:p0c6x7-pro_0000037317(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0114"(x-ray crystallography) Ferron et al. (2018) pubmed:29279395|imex:IM-27867 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-25499834|pdbe:5NFY|imex:IM-27867-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) - chain-seq-start:5903|chain-seq-end:6429 chain-seq-start:4231|chain-seq-end:4369 figure legend:Table S1|3d-r-factors:"Rwork: 0.193 Rfree: 0.235"|3d-resolution:3.38Å|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/04/03 2020/04/06 rogid:FPQjk4Qo6mt2gs5v5hPwe+xPyrI694009 rogid:/fARNiV2WEOqFni2l3o4/cqF7Bk694009 rigid:MHZX7DgDL3ERsxxwkDshr2Xthbc false his tag:n-n his tag:n-n 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0C6X7-PRO_0000037320 uniprotkb:P0C6X7-PRO_0000037318 intact:EBI-25487328 intact:EBI-25487684 psi-mi:p0c6x7-pro_0000037320(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:p0c6x7-pro_0000037318(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0096"(pull down) Ferron et al. (2018) pubmed:29279395|imex:IM-27867 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-25499914|imex:IM-27867-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) - chain-seq-start:5903|chain-seq-end:6429 chain-seq-start:4370|chain-seq-end:5301 figure legend:Fig. S6, Table S2|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/04/03 2020/04/06 rogid:FPQjk4Qo6mt2gs5v5hPwe+xPyrI694009 rogid:eeAJDsSyQ9Qfnm1xY+XJWlCGwWY694009 rigid:Y9c33thEHxxGSiyeiOQpbr6fTH0 false mutation decreasing interaction strength:296-296|mutation decreasing interaction strength:297-297|mutation decreasing interaction strength:473-473|mutation decreasing interaction strength:475-475|mutation disrupting interaction strength:487-487|mutation decreasing interaction strength:495-495|mutation disrupting interaction strength:498-498|mutation decreasing interaction strength:499-499|his tag:n-n|mutation decreasing interaction strength:306-306|mutation decreasing interaction strength:90-90,92-92|mutation decreasing interaction strength:310-310|mutation increasing interaction strength:466-466|mutation increasing interaction strength:468-468|mutation increasing interaction strength:469-469|mutation increasing interaction strength:479-479 glutathione s tranferase tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P0C6X7-PRO_0000037320 uniprotkb:P0C6X7-PRO_0000037318 intact:EBI-25487328 intact:EBI-25487684 psi-mi:p0c6x7-pro_0000037320(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:p0c6x7-pro_0000037318(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0096"(pull down) Ferron et al. (2018) pubmed:29279395|imex:IM-27867 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25500203|imex:IM-27867-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) - chain-seq-start:5903|chain-seq-end:6429 chain-seq-start:4370|chain-seq-end:5301 figure legend:Fig S4|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/04/03 2020/04/27 rogid:FPQjk4Qo6mt2gs5v5hPwe+xPyrI694009 rogid:eeAJDsSyQ9Qfnm1xY+XJWlCGwWY694009 rigid:Y9c33thEHxxGSiyeiOQpbr6fTH0 false 35s radiolabel:?-?|sufficient binding region:72-322 glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)