#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q04741	uniprotkb:Q9BZH6	intact:EBI-26568770|ensembl:ENSP00000258106|uniprotkb:Q0D2P0|uniprotkb:Q53T30|uniprotkb:Q86XB0	intact:EBI-2009923|uniprotkb:Q5VWA1|uniprotkb:Q9P2J6|ensembl:ENSP00000263461	psi-mi:emx1_human(display_long)|uniprotkb:Empty spiracles homolog 1(gene name synonym)|uniprotkb:Empty spiracles-like protein 1(gene name synonym)|uniprotkb:EMX1(gene name)|psi-mi:EMX1(display_short)	psi-mi:wdr11_human(display_long)|uniprotkb:WDR11(gene name)|psi-mi:WDR11(display_short)|uniprotkb:KIAA1351(gene name synonym)|uniprotkb:BRWD2(gene name synonym)|uniprotkb:WDR15(gene name synonym)|uniprotkb:Bromodomain and WD repeat-containing protein 2(gene name synonym)|uniprotkb:WD repeat-containing protein 15(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kim et al. (2018)	imex:IM-28588|pubmed:29263200	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26568810|imex:IM-28588-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000135638(gene)|ensembl:ENST00000258106(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007417"(central nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021796"(cerebral cortex regionalization)|go:"GO:0021895"(cerebral cortex neuron differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0042493"|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060563"(neuroepithelial cell differentiation)|go:"GO:0070445"(regulation of oligodendrocyte progenitor proliferation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR020479|mint:Q04741|refseq:NP_004088.2|refseq:XP_011530999.1	refseq:NP_060587.8|ensembl:ENSG00000120008(gene)|ensembl:ENST00000263461(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007507"(heart development)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036064"(ciliary basal body)|go:"GO:0060271"(cilium assembly)|go:"GO:0060322"(head development)|go:"GO:0099041"(vesicle tethering to Golgi)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR039694|mint:Q9BZH6|reactome:R-HSA-9013407	-	-	-	figure legend:"f5a (left)"|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2020/12/23	2021/06/18	rogid:1JOu5FpZmRUuMUKzFVgHWAPd4Ns9606	rogid:Kl337t8mCHvvkb8oi0z8Ohl72a09606	rigid:ct7Swol/wkcIOBC9Ur6JGgpcMPI	false	ha tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BZH6	uniprotkb:P10071	intact:EBI-2009923|uniprotkb:Q5VWA1|uniprotkb:Q9P2J6|ensembl:ENSP00000263461	intact:EBI-308055|uniprotkb:A4D1W1|uniprotkb:O75219|uniprotkb:Q17RW4|uniprotkb:Q75MT0|uniprotkb:Q75MU9|uniprotkb:Q9UDT5|uniprotkb:Q9UJ39|ensembl:ENSP00000379258|ensembl:ENSP00000502957|ensembl:ENSP00000503743	psi-mi:wdr11_human(display_long)|uniprotkb:WDR11(gene name)|psi-mi:WDR11(display_short)|uniprotkb:KIAA1351(gene name synonym)|uniprotkb:BRWD2(gene name synonym)|uniprotkb:WDR15(gene name synonym)|uniprotkb:Bromodomain and WD repeat-containing protein 2(gene name synonym)|uniprotkb:WD repeat-containing protein 15(gene name synonym)	psi-mi:gli3_human(display_long)|uniprotkb:GLI3(gene name)|psi-mi:GLI3(display_short)|uniprotkb:GLI3 full-length protein(gene name synonym)|uniprotkb:GLI3 form of 190 kDa(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kim et al. (2018)	imex:IM-28588|pubmed:29263200	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26568818|imex:IM-28588-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060587.8|ensembl:ENSG00000120008(gene)|ensembl:ENST00000263461(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007507"(heart development)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036064"(ciliary basal body)|go:"GO:0060271"(cilium assembly)|go:"GO:0060322"(head development)|go:"GO:0099041"(vesicle tethering to Golgi)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR039694|mint:Q9BZH6|reactome:R-HSA-9013407	refseq:NP_000159.3|ensembl:ENSG00000106571(gene)|ensembl:ENST00000395925(transcript)|ensembl:ENST00000677605(transcript)|ensembl:ENST00000678429(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007442"(hindgut morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0016485"(protein processing)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0021631"(optic nerve morphogenesis)|go:"GO:0021766"(hippocampus development)|go:"GO:0021775"(smoothened signaling pathway involved in ventral spinal cord interneuron specification)|go:"GO:0021776"(smoothened signaling pathway involved in spinal cord motor neuron cell fate specification)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0022018"(lateral ganglionic eminence cell proliferation)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030850"(prostate gland development)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0036033"(mediator complex binding)|go:"GO:0042060"(wound healing)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0060594"(mammary gland specification)|go:"GO:0060831"(smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:0060840"(artery development)|go:"GO:0060873"(anterior semicircular canal development)|go:"GO:0060875"(lateral semicircular canal development)|go:"GO:0061005"(cell differentiation involved in kidney development)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0071625"(vocalization behavior)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|go:"GO:0097542"(ciliary tip)|go:"GO:0097546"(ciliary base)|go:"GO:0120223"(larynx morphogenesis)|go:"GO:1901620"(regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:1903010"(regulation of bone development)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043585"(nose morphogenesis)|go:"GO:0043586"(tongue development)|go:"GO:0043627"(response to estrogen)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045665"(negative regulation of neuron differentiation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR032851|interpro:IPR036236|interpro:IPR043359|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|mint:P10071|rcsb pdb:4BLD|reactome:R-HSA-5610785|reactome:R-HSA-5610787|reactome:R-HSA-5632684|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|reactome:R-HSA-5635851|reactome:R-HSA-8940973|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046639"(negative regulation of alpha-beta T cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0048589"(developmental growth)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060364"(frontal suture morphogenesis)|go:"GO:0060366"(lambdoid suture morphogenesis)|go:"GO:0060367"(sagittal suture morphogenesis)|dip:DIP-32538N	-	-	-	figure legend:"f5a (left)"|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2020/12/23	2021/06/18	rogid:Kl337t8mCHvvkb8oi0z8Ohl72a09606	rogid:BOHGgIuKgq0gUSahFeRaKnRmoMs9606	rigid:JAbQIeQt9oMDqhg1yb5/w1aMuQg	false	myc tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BZH6	uniprotkb:Q04741	intact:EBI-2009923|uniprotkb:Q5VWA1|uniprotkb:Q9P2J6|ensembl:ENSP00000263461	intact:EBI-26568770|ensembl:ENSP00000258106|uniprotkb:Q0D2P0|uniprotkb:Q53T30|uniprotkb:Q86XB0	psi-mi:wdr11_human(display_long)|uniprotkb:WDR11(gene name)|psi-mi:WDR11(display_short)|uniprotkb:KIAA1351(gene name synonym)|uniprotkb:BRWD2(gene name synonym)|uniprotkb:WDR15(gene name synonym)|uniprotkb:Bromodomain and WD repeat-containing protein 2(gene name synonym)|uniprotkb:WD repeat-containing protein 15(gene name synonym)	psi-mi:emx1_human(display_long)|uniprotkb:Empty spiracles homolog 1(gene name synonym)|uniprotkb:Empty spiracles-like protein 1(gene name synonym)|uniprotkb:EMX1(gene name)|psi-mi:EMX1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kim et al. (2018)	imex:IM-28588|pubmed:29263200	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26568818|imex:IM-28588-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060587.8|ensembl:ENSG00000120008(gene)|ensembl:ENST00000263461(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007507"(heart development)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036064"(ciliary basal body)|go:"GO:0060271"(cilium assembly)|go:"GO:0060322"(head development)|go:"GO:0099041"(vesicle tethering to Golgi)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR039694|mint:Q9BZH6|reactome:R-HSA-9013407	ensembl:ENSG00000135638(gene)|ensembl:ENST00000258106(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007417"(central nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021796"(cerebral cortex regionalization)|go:"GO:0021895"(cerebral cortex neuron differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0042493"|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060563"(neuroepithelial cell differentiation)|go:"GO:0070445"(regulation of oligodendrocyte progenitor proliferation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR020479|mint:Q04741|refseq:NP_004088.2|refseq:XP_011530999.1	-	-	-	figure legend:"f5a (left)"|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2020/12/23	2021/06/18	rogid:Kl337t8mCHvvkb8oi0z8Ohl72a09606	rogid:1JOu5FpZmRUuMUKzFVgHWAPd4Ns9606	rigid:JAbQIeQt9oMDqhg1yb5/w1aMuQg	false	myc tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q04741	uniprotkb:P10071-PRO_0000406137	intact:EBI-26568770|ensembl:ENSP00000258106|uniprotkb:Q0D2P0|uniprotkb:Q53T30|uniprotkb:Q86XB0	intact:EBI-26568850	psi-mi:emx1_human(display_long)|uniprotkb:Empty spiracles homolog 1(gene name synonym)|uniprotkb:Empty spiracles-like protein 1(gene name synonym)|uniprotkb:EMX1(gene name)|psi-mi:EMX1(display_short)	psi-mi:p10071-pro_0000406137(display_long)|uniprotkb:GLI3(gene name)|psi-mi:GLI3(display_short)|uniprotkb:GLI3 form of 190 kDa(gene name synonym)|uniprotkb:GLI3 full-length protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kim et al. (2018)	imex:IM-28588|pubmed:29263200	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26568827|imex:IM-28588-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000135638(gene)|ensembl:ENST00000258106(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007417"(central nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021796"(cerebral cortex regionalization)|go:"GO:0021895"(cerebral cortex neuron differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0042493"|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060563"(neuroepithelial cell differentiation)|go:"GO:0070445"(regulation of oligodendrocyte progenitor proliferation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR020479|mint:Q04741|refseq:NP_004088.2|refseq:XP_011530999.1	intact:EBI-308055(chain-parent)	-	-	chain-seq-start:1|chain-seq-end:?	figure legend:"f5a (right)"|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2020/12/23	2021/06/18	rogid:1JOu5FpZmRUuMUKzFVgHWAPd4Ns9606	-	-	false	ha tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P10071-PRO_0000406137	uniprotkb:Q9BZH6	intact:EBI-26568850	intact:EBI-2009923|uniprotkb:Q5VWA1|uniprotkb:Q9P2J6|ensembl:ENSP00000263461	psi-mi:p10071-pro_0000406137(display_long)|uniprotkb:GLI3(gene name)|psi-mi:GLI3(display_short)|uniprotkb:GLI3 form of 190 kDa(gene name synonym)|uniprotkb:GLI3 full-length protein(gene name synonym)	psi-mi:wdr11_human(display_long)|uniprotkb:WDR11(gene name)|psi-mi:WDR11(display_short)|uniprotkb:KIAA1351(gene name synonym)|uniprotkb:BRWD2(gene name synonym)|uniprotkb:WDR15(gene name synonym)|uniprotkb:Bromodomain and WD repeat-containing protein 2(gene name synonym)|uniprotkb:WD repeat-containing protein 15(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kim et al. (2018)	imex:IM-28588|pubmed:29263200	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26568835|imex:IM-28588-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-308055(chain-parent)	refseq:NP_060587.8|ensembl:ENSG00000120008(gene)|ensembl:ENST00000263461(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007507"(heart development)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036064"(ciliary basal body)|go:"GO:0060271"(cilium assembly)|go:"GO:0060322"(head development)|go:"GO:0099041"(vesicle tethering to Golgi)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR039694|mint:Q9BZH6|reactome:R-HSA-9013407	-	chain-seq-start:1|chain-seq-end:?	-	figure legend:"f5a (right)"|comment:The disease‐associated mutant WDR11 showed a reduced binding capacity to EMX1 within this complex|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2020/12/23	2021/06/18	-	rogid:Kl337t8mCHvvkb8oi0z8Ohl72a09606	-	false	myc tag:?-?	mutation:537-537|mutation:690-690|mutation:435-435	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P10071-PRO_0000406137	uniprotkb:Q04741	intact:EBI-26568850	intact:EBI-26568770|ensembl:ENSP00000258106|uniprotkb:Q0D2P0|uniprotkb:Q53T30|uniprotkb:Q86XB0	psi-mi:p10071-pro_0000406137(display_long)|uniprotkb:GLI3(gene name)|psi-mi:GLI3(display_short)|uniprotkb:GLI3 form of 190 kDa(gene name synonym)|uniprotkb:GLI3 full-length protein(gene name synonym)	psi-mi:emx1_human(display_long)|uniprotkb:Empty spiracles homolog 1(gene name synonym)|uniprotkb:Empty spiracles-like protein 1(gene name synonym)|uniprotkb:EMX1(gene name)|psi-mi:EMX1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kim et al. (2018)	imex:IM-28588|pubmed:29263200	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26568835|imex:IM-28588-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-308055(chain-parent)	ensembl:ENSG00000135638(gene)|ensembl:ENST00000258106(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007417"(central nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021796"(cerebral cortex regionalization)|go:"GO:0021895"(cerebral cortex neuron differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0042493"|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060563"(neuroepithelial cell differentiation)|go:"GO:0070445"(regulation of oligodendrocyte progenitor proliferation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR020479|mint:Q04741|refseq:NP_004088.2|refseq:XP_011530999.1	-	chain-seq-start:1|chain-seq-end:?	-	figure legend:"f5a (right)"|comment:The disease‐associated mutant WDR11 showed a reduced binding capacity to EMX1 within this complex|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2020/12/23	2021/06/18	-	rogid:1JOu5FpZmRUuMUKzFVgHWAPd4Ns9606	-	false	myc tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BZH6	uniprotkb:P10071	intact:EBI-2009923|uniprotkb:Q5VWA1|uniprotkb:Q9P2J6|ensembl:ENSP00000263461	intact:EBI-308055|uniprotkb:A4D1W1|uniprotkb:O75219|uniprotkb:Q17RW4|uniprotkb:Q75MT0|uniprotkb:Q75MU9|uniprotkb:Q9UDT5|uniprotkb:Q9UJ39|ensembl:ENSP00000379258|ensembl:ENSP00000502957|ensembl:ENSP00000503743	psi-mi:wdr11_human(display_long)|uniprotkb:WDR11(gene name)|psi-mi:WDR11(display_short)|uniprotkb:KIAA1351(gene name synonym)|uniprotkb:BRWD2(gene name synonym)|uniprotkb:WDR15(gene name synonym)|uniprotkb:Bromodomain and WD repeat-containing protein 2(gene name synonym)|uniprotkb:WD repeat-containing protein 15(gene name synonym)	psi-mi:gli3_human(display_long)|uniprotkb:GLI3(gene name)|psi-mi:GLI3(display_short)|uniprotkb:GLI3 full-length protein(gene name synonym)|uniprotkb:GLI3 form of 190 kDa(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kim et al. (2018)	imex:IM-28588|pubmed:29263200	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26568932|imex:IM-28588-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060587.8|ensembl:ENSG00000120008(gene)|ensembl:ENST00000263461(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007507"(heart development)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036064"(ciliary basal body)|go:"GO:0060271"(cilium assembly)|go:"GO:0060322"(head development)|go:"GO:0099041"(vesicle tethering to Golgi)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR039694|mint:Q9BZH6|reactome:R-HSA-9013407	refseq:NP_000159.3|ensembl:ENSG00000106571(gene)|ensembl:ENST00000395925(transcript)|ensembl:ENST00000677605(transcript)|ensembl:ENST00000678429(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007442"(hindgut morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0016485"(protein processing)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0021631"(optic nerve morphogenesis)|go:"GO:0021766"(hippocampus development)|go:"GO:0021775"(smoothened signaling pathway involved in ventral spinal cord interneuron specification)|go:"GO:0021776"(smoothened signaling pathway involved in spinal cord motor neuron cell fate specification)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0022018"(lateral ganglionic eminence cell proliferation)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030850"(prostate gland development)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0036033"(mediator complex binding)|go:"GO:0042060"(wound healing)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0060594"(mammary gland specification)|go:"GO:0060831"(smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:0060840"(artery development)|go:"GO:0060873"(anterior semicircular canal development)|go:"GO:0060875"(lateral semicircular canal development)|go:"GO:0061005"(cell differentiation involved in kidney development)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0071625"(vocalization behavior)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|go:"GO:0097542"(ciliary tip)|go:"GO:0097546"(ciliary base)|go:"GO:0120223"(larynx morphogenesis)|go:"GO:1901620"(regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:1903010"(regulation of bone development)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043585"(nose morphogenesis)|go:"GO:0043586"(tongue development)|go:"GO:0043627"(response to estrogen)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045665"(negative regulation of neuron differentiation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR032851|interpro:IPR036236|interpro:IPR043359|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|mint:P10071|rcsb pdb:4BLD|reactome:R-HSA-5610785|reactome:R-HSA-5610787|reactome:R-HSA-5632684|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|reactome:R-HSA-5635851|reactome:R-HSA-8940973|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046639"(negative regulation of alpha-beta T cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0048589"(developmental growth)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060364"(frontal suture morphogenesis)|go:"GO:0060366"(lambdoid suture morphogenesis)|go:"GO:0060367"(sagittal suture morphogenesis)|dip:DIP-32538N	-	-	-	figure legend:Figure EV2|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2020/12/23	2020/12/23	rogid:Kl337t8mCHvvkb8oi0z8Ohl72a09606	rogid:BOHGgIuKgq0gUSahFeRaKnRmoMs9606	-	false	myc tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BZH6	uniprotkb:P10071-PRO_0000406137	intact:EBI-2009923|uniprotkb:Q5VWA1|uniprotkb:Q9P2J6|ensembl:ENSP00000263461	intact:EBI-26568850	psi-mi:wdr11_human(display_long)|uniprotkb:WDR11(gene name)|psi-mi:WDR11(display_short)|uniprotkb:KIAA1351(gene name synonym)|uniprotkb:BRWD2(gene name synonym)|uniprotkb:WDR15(gene name synonym)|uniprotkb:Bromodomain and WD repeat-containing protein 2(gene name synonym)|uniprotkb:WD repeat-containing protein 15(gene name synonym)	psi-mi:p10071-pro_0000406137(display_long)|uniprotkb:GLI3(gene name)|psi-mi:GLI3(display_short)|uniprotkb:GLI3 form of 190 kDa(gene name synonym)|uniprotkb:GLI3 full-length protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kim et al. (2018)	imex:IM-28588|pubmed:29263200	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26568932|imex:IM-28588-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060587.8|ensembl:ENSG00000120008(gene)|ensembl:ENST00000263461(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007507"(heart development)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036064"(ciliary basal body)|go:"GO:0060271"(cilium assembly)|go:"GO:0060322"(head development)|go:"GO:0099041"(vesicle tethering to Golgi)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR039694|mint:Q9BZH6|reactome:R-HSA-9013407	intact:EBI-308055(chain-parent)	-	-	chain-seq-start:1|chain-seq-end:?	figure legend:Figure EV2|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2020/12/23	2020/12/23	rogid:Kl337t8mCHvvkb8oi0z8Ohl72a09606	-	-	false	myc tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BZH6	uniprotkb:P10071-PRO_0000406137	intact:EBI-2009923|uniprotkb:Q5VWA1|uniprotkb:Q9P2J6|ensembl:ENSP00000263461	intact:EBI-26568850	psi-mi:wdr11_human(display_long)|uniprotkb:WDR11(gene name)|psi-mi:WDR11(display_short)|uniprotkb:KIAA1351(gene name synonym)|uniprotkb:BRWD2(gene name synonym)|uniprotkb:WDR15(gene name synonym)|uniprotkb:Bromodomain and WD repeat-containing protein 2(gene name synonym)|uniprotkb:WD repeat-containing protein 15(gene name synonym)	psi-mi:p10071-pro_0000406137(display_long)|uniprotkb:GLI3(gene name)|psi-mi:GLI3(display_short)|uniprotkb:GLI3 form of 190 kDa(gene name synonym)|uniprotkb:GLI3 full-length protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kim et al. (2018)	imex:IM-28588|pubmed:29263200	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26582195|imex:IM-28588-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060587.8|ensembl:ENSG00000120008(gene)|ensembl:ENST00000263461(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007507"(heart development)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036064"(ciliary basal body)|go:"GO:0060271"(cilium assembly)|go:"GO:0060322"(head development)|go:"GO:0099041"(vesicle tethering to Golgi)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR039694|mint:Q9BZH6|reactome:R-HSA-9013407	intact:EBI-308055(chain-parent)	-	-	chain-seq-start:1|chain-seq-end:?	figure legend:"f5a (right)"|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2020/12/23	2021/01/04	rogid:Kl337t8mCHvvkb8oi0z8Ohl72a09606	-	-	false	mutation with no effect:537-537|mutation with no effect:690-690|mutation with no effect:435-435	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P10071-PRO_0000406137	uniprotkb:Q04741	intact:EBI-26568850	intact:EBI-26568770|ensembl:ENSP00000258106|uniprotkb:Q0D2P0|uniprotkb:Q53T30|uniprotkb:Q86XB0	psi-mi:p10071-pro_0000406137(display_long)|uniprotkb:GLI3(gene name)|psi-mi:GLI3(display_short)|uniprotkb:GLI3 form of 190 kDa(gene name synonym)|uniprotkb:GLI3 full-length protein(gene name synonym)	psi-mi:emx1_human(display_long)|uniprotkb:Empty spiracles homolog 1(gene name synonym)|uniprotkb:Empty spiracles-like protein 1(gene name synonym)|uniprotkb:EMX1(gene name)|psi-mi:EMX1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kim et al. (2018)	imex:IM-28588|pubmed:29263200	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26568920|imex:IM-28588-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-308055(chain-parent)	ensembl:ENSG00000135638(gene)|ensembl:ENST00000258106(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007417"(central nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021796"(cerebral cortex regionalization)|go:"GO:0021895"(cerebral cortex neuron differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0042493"|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060563"(neuroepithelial cell differentiation)|go:"GO:0070445"(regulation of oligodendrocyte progenitor proliferation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR020479|mint:Q04741|refseq:NP_004088.2|refseq:XP_011530999.1	-	chain-seq-start:1|chain-seq-end:?	-	figure legend:f5c|comment:"However, EMX1 alone could not bind to GLI3 in the absence of WDR11, as EMX1/GLI3 binary complex could not be precipitated from Wdr11−/− MEFs, contrary to the WT MEFs or HEK293 cells which express endogenous WDR11 (Fig 5C)."|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2020/12/23	2021/06/18	-	rogid:1JOu5FpZmRUuMUKzFVgHWAPd4Ns9606	-	false	myc tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P10071-PRO_0000406137	uniprotkb:Q8K1X1	intact:EBI-26568850	intact:EBI-26568885|uniprotkb:Q69ZL3|uniprotkb:Q8C937	psi-mi:p10071-pro_0000406137(display_long)|uniprotkb:GLI3(gene name)|psi-mi:GLI3(display_short)|uniprotkb:GLI3 form of 190 kDa(gene name synonym)|uniprotkb:GLI3 full-length protein(gene name synonym)	psi-mi:wdr11_mouse(display_long)|uniprotkb:Bromodomain and WD repeat-containing protein 2(gene name synonym)|uniprotkb:Wdr11(gene name)|psi-mi:Wdr11(display_short)|uniprotkb:Brwd2(gene name synonym)|uniprotkb:Kiaa1351(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kim et al. (2018)	imex:IM-28588|pubmed:29263200	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26568920|imex:IM-28588-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-308055(chain-parent)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007507"(heart development)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0036064"(ciliary basal body)|go:"GO:0060271"(cilium assembly)|go:"GO:0060322"(head development)|go:"GO:0099041"(vesicle tethering to Golgi)|reactome:R-MMU-9013407|go:"GO:0035264"(multicellular organism growth)|mint:Q8K1X1|refseq:NP_758459.2|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR019775|interpro:IPR036322|interpro:IPR039694	-	chain-seq-start:1|chain-seq-end:?	-	figure legend:f5c|comment:"However, EMX1 alone could not bind to GLI3 in the absence of WDR11, as EMX1/GLI3 binary complex could not be precipitated from Wdr11−/− MEFs, contrary to the WT MEFs or HEK293 cells which express endogenous WDR11 (Fig 5C)."|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2020/12/23	2021/06/18	-	rogid:nIRLCssKN22Q7tBG3efCQ0W+pCY10090	-	false	myc tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8K1X1	uniprotkb:Q61602	intact:EBI-26568885|uniprotkb:Q69ZL3|uniprotkb:Q8C937	intact:EBI-10829058|ensembl:ENSMUSP00000106137	psi-mi:wdr11_mouse(display_long)|uniprotkb:Bromodomain and WD repeat-containing protein 2(gene name synonym)|uniprotkb:Wdr11(gene name)|psi-mi:Wdr11(display_short)|uniprotkb:Brwd2(gene name synonym)|uniprotkb:Kiaa1351(gene name synonym)	psi-mi:gli3_mouse(display_long)|uniprotkb:GLI3 full-length protein(gene name synonym)|uniprotkb:GLI3 form of 190 kDa(gene name synonym)|uniprotkb:Gli3(gene name)|psi-mi:Gli3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kim et al. (2018)	imex:IM-28588|pubmed:29263200	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26568916|imex:IM-28588-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007507"(heart development)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0036064"(ciliary basal body)|go:"GO:0060271"(cilium assembly)|go:"GO:0060322"(head development)|go:"GO:0099041"(vesicle tethering to Golgi)|reactome:R-MMU-9013407|go:"GO:0035264"(multicellular organism growth)|mint:Q8K1X1|refseq:NP_758459.2|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR019775|interpro:IPR036322|interpro:IPR039694	go:"GO:0021631"(optic nerve morphogenesis)|go:"GO:0021766"(hippocampus development)|go:"GO:0021775"(smoothened signaling pathway involved in ventral spinal cord interneuron specification)|go:"GO:0021776"(smoothened signaling pathway involved in spinal cord motor neuron cell fate specification)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0021801"(cerebral cortex radial glia-guided migration)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0021915"(neural tube development)|go:"GO:0022018"(lateral ganglionic eminence cell proliferation)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030850"(prostate gland development)|go:"GO:0030879"(mammary gland development)|go:"GO:0030900"(forebrain development)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0035295"(tube development)|go:"GO:0036033"(mediator complex binding)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043586"(tongue development)|go:"GO:0043627"(response to estrogen)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046639"(negative regulation of alpha-beta T cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0048589"(developmental growth)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048839"(inner ear development)|go:"GO:0048856"(anatomical structure development)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060173"(limb development)|go:"GO:0060364"(frontal suture morphogenesis)|go:"GO:0060366"(lambdoid suture morphogenesis)|go:"GO:0060367"(sagittal suture morphogenesis)|go:"GO:0060594"(mammary gland specification)|go:"GO:0060831"(smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:0060840"(artery development)|go:"GO:0060873"(anterior semicircular canal development)|go:"GO:0060875"(lateral semicircular canal development)|go:"GO:0061005"(cell differentiation involved in kidney development)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0071625"(vocalization behavior)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|go:"GO:0120223"(larynx morphogenesis)|go:"GO:1901620"(regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:1903010"(regulation of bone development)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR032851|interpro:IPR036236|interpro:IPR043359|mint:Q61602|reactome:R-MMU-5610785|reactome:R-MMU-5610787|reactome:R-MMU-5632684|ensembl:ENSMUSG00000021318(gene)|ensembl:ENSMUST00000110510(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007389"(pattern specification process)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007442"(hindgut morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016485"(protein processing)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0021513"(spinal cord dorsal/ventral patterning)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021537"(telencephalon development)|go:"GO:0021543"(pallium development)|go:"GO:0021544"(subpallium development)|refseq:NP_032156.2	-	-	-	figure legend:F5B|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis)	-	2020/12/23	2021/01/04	rogid:nIRLCssKN22Q7tBG3efCQ0W+pCY10090	rogid:el+Tr+Vp7SsDEyK+ljxkHgLFZ1s10090	rigid:uIuq9SdDXn2dM6Q/kOi4uO4nOh0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)