#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8BHY3	uniprotkb:Q8BHY3	intact:EBI-11795280|uniprotkb:Q6P5C6|uniprotkb:Q8BI26|uniprotkb:Q99JK1	intact:EBI-11795280|uniprotkb:Q6P5C6|uniprotkb:Q8BI26|uniprotkb:Q99JK1	psi-mi:ano1_mouse(display_long)|uniprotkb:Ano1(gene name)|psi-mi:Ano1(display_short)|uniprotkb:Tmem16a(gene name synonym)|uniprotkb:Transmembrane protein 16A(gene name synonym)	psi-mi:ano1_mouse(display_long)|uniprotkb:Ano1(gene name)|psi-mi:Ano1(display_short)|uniprotkb:Tmem16a(gene name synonym)|uniprotkb:Transmembrane protein 16A(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Paulino et al. (2017)	imex:IM-27756|pubmed:29236691	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-25448865|wwpdb:5OYB|wwpdb:5OYG|emdb:EMD-3860|emdb:EMD-3861|imex:IM-27756-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001229278.1|refseq:NP_848757.4|reactome:R-MMU-2672351|interpro:IPR032394|interpro:IPR007632(Protein of unknown function DUF590)|rcsb pdb:5OYB|rcsb pdb:5OYG|rcsb pdb:6BGI|rcsb pdb:6BGJ|rcsb pdb:7B5C|rcsb pdb:7B5D|rcsb pdb:7B5E|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005227"(calcium activated cation channel activity)|go:"GO:0005229"(intracellular calcium activated chloride channel activity)|go:"GO:0005247"(voltage-gated chloride channel activity)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006821"(chloride transport)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015111"(iodide transmembrane transporter activity)|go:"GO:0015705"(iodide transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034707"(chloride channel complex)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0055085"(transmembrane transport)|go:"GO:0060438"(trachea development)|go:"GO:1901653"(cellular response to peptide)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:0006812"(cation transport)|rcsb pdb:5NL2|interpro:IPR031287	refseq:NP_001229278.1|refseq:NP_848757.4|reactome:R-MMU-2672351|interpro:IPR032394|interpro:IPR007632(Protein of unknown function DUF590)|rcsb pdb:5OYB|rcsb pdb:5OYG|rcsb pdb:6BGI|rcsb pdb:6BGJ|rcsb pdb:7B5C|rcsb pdb:7B5D|rcsb pdb:7B5E|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005227"(calcium activated cation channel activity)|go:"GO:0005229"(intracellular calcium activated chloride channel activity)|go:"GO:0005247"(voltage-gated chloride channel activity)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006821"(chloride transport)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015111"(iodide transmembrane transporter activity)|go:"GO:0015705"(iodide transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034707"(chloride channel complex)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0055085"(transmembrane transport)|go:"GO:0060438"(trachea development)|go:"GO:1901653"(cellular response to peptide)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:0006812"(cation transport)|rcsb pdb:5NL2|interpro:IPR031287	-	-	-	figure legend:Extended Data Figure 1c,d,2,  Extended Data Figure 10a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2020/01/28	2020/03/03	rogid:MrgcaAxymoN2GOh4AbZTizFTb+M10090	rogid:MrgcaAxymoN2GOh4AbZTizFTb+M10090	rigid:gqGdVeg7cagCXDjO2kZlBkXi/uU	false	-	-	2	0	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)