#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:K0BWD0	uniprotkb:P05161	intact:EBI-25565992	intact:EBI-746466|uniprotkb:Q7Z2G2|uniprotkb:Q96GF0|intact:EBI-1056284|uniprotkb:Q5SVA4|ensembl:ENSP00000496832	psi-mi:k0bwd0_mers(display_long)|uniprotkb:orf1ab(gene name)|psi-mi:orf1ab(display_short)|uniprotkb:3C-like proteinase(gene name synonym)|uniprotkb:Growth factor-like peptide(gene name synonym)|uniprotkb:Guanine-N7 methyltransferase(gene name synonym)|uniprotkb:Helicase(gene name synonym)|uniprotkb:Host translation inhibitor nsp1(gene name synonym)|uniprotkb:Leader protein(gene name synonym)|uniprotkb:NendoU(gene name synonym)|uniprotkb:Non-structural protein 10(gene name synonym)|uniprotkb:Non-structural protein 2(gene name synonym)|uniprotkb:Non-structural protein 3(gene name synonym)|uniprotkb:Non-structural protein 4(gene name synonym)|uniprotkb:Non-structural protein 6(gene name synonym)|uniprotkb:Non-structural protein 7(gene name synonym)|uniprotkb:Non-structural protein 8(gene name synonym)|uniprotkb:Non-structural protein 9(gene name synonym)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:Papain-like proteinase(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym)|uniprotkb:Uridylate-specific endoribonuclease(gene name synonym)|uniprotkb:nsp5(gene name synonym)|uniprotkb:p65 homolog(gene name synonym)|uniprotkb:nsp12(gene name synonym)|uniprotkb:nsp14(gene name synonym)|uniprotkb:nsp15(gene name synonym)|uniprotkb:nsp13(gene name synonym)|uniprotkb:nsp16(gene name synonym)	psi-mi:isg15_human(display_long)|uniprotkb:ISG15(gene name)|psi-mi:ISG15(display_short)|uniprotkb:G1P2(gene name synonym)|uniprotkb:UCRP(gene name synonym)|uniprotkb:Interferon-induced 15 kDa protein(gene name synonym)|uniprotkb:Interferon-induced 17 kDa protein(gene name synonym)|uniprotkb:Ubiquitin cross-reactive protein(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Daczkowski et al. (2017)	pubmed:28931677|imex:IM-27920	taxid:1235996(cv2ce)|taxid:1235996(Human betacoronavirus 2c EMC/2012)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25565604|imex:IM-27920-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005524"(ATP binding)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0032259"(methylation)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|interpro:IPR022733|interpro:IPR044315|interpro:IPR044327|interpro:IPR044330|rcsb pdb:4P16|rcsb pdb:5V69|rcsb pdb:5V6A|rcsb pdb:5WWP|rcsb pdb:5YN5|rcsb pdb:5YN6|rcsb pdb:5YN8|rcsb pdb:5YNB|rcsb pdb:5YNF|rcsb pdb:5YNI|rcsb pdb:5YNJ|rcsb pdb:5YNM|rcsb pdb:5YNN|rcsb pdb:5YNO|rcsb pdb:5YNP|rcsb pdb:5YNQ|rcsb pdb:6BI8|interpro:IPR027351|interpro:IPR032505|interpro:IPR009461(Coronavirus NSP13)|interpro:IPR027352|interpro:IPR041679|interpro:IPR037227|interpro:IPR002589(Appr-1-p processing)|interpro:IPR032592|interpro:IPR042570|interpro:IPR036333|interpro:IPR009466(NSP11)|interpro:IPR042515|interpro:IPR024375|interpro:IPR038400|interpro:IPR038123|interpro:IPR014828(Nsp7 replicase)|interpro:IPR037204|interpro:IPR014829(Nsp8 replicase)|interpro:IPR037230|interpro:IPR014822(Nsp9 replicase)|interpro:IPR036499|interpro:IPR027417|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR038083|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR009469(RNA polymerase, N-terminal, coronaviral)|interpro:IPR018995|interpro:IPR029063|interpro:IPR043174|interpro:IPR043177|interpro:IPR043178|interpro:IPR043472|interpro:IPR043477|interpro:IPR043502|interpro:IPR043503|interpro:IPR043504|interpro:IPR021590|interpro:IPR043606|interpro:IPR043608|interpro:IPR043609|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|interpro:IPR044343|interpro:IPR044350|interpro:IPR044353|interpro:IPR044357|interpro:IPR044367|interpro:IPR044371|interpro:IPR044382|interpro:IPR044388|interpro:IPR044401	refseq:NP_005092.1|ensembl:ENSG00000187608(gene)|ensembl:ENST00000649529(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009615"(response to virus)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031386"(protein tag)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032020"(ISG15-protein conjugation)|go:"GO:0032461"(positive regulation of protein oligomerization)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034340"(response to type I interferon)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0070585"(protein localization to mitochondrion)|interpro:IPR000626(Ubiquitin)|interpro:IPR019956|interpro:IPR029071|mint:P05161|rcsb pdb:1Z2M|rcsb pdb:2HJ8|rcsb pdb:3PHX|rcsb pdb:3PSE|rcsb pdb:3R66|rcsb pdb:3RT3|rcsb pdb:3SDL|rcsb pdb:5TL6|rcsb pdb:5W8T|rcsb pdb:5W8U|rcsb pdb:6BI8|rcsb pdb:6FFA|rcsb pdb:6XA9|reactome:R-HSA-1169408|reactome:R-HSA-168276|reactome:R-HSA-168928|reactome:R-HSA-5656169|reactome:R-HSA-909733|reactome:R-HSA-936440|dip:DIP-29814N	-	-	-	figure legend:Table 1, Fig. 2a|comment:Papain-like protease domain range was inferred from the sequence provided in Fig. 1|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:27.06x10^-6 ~3.04(molar)	2020/04/16	2020/04/17	rogid:u9TWbKf58gKvK2U0hDw6YNZrBo81235996	rogid:k01VuKv72XNTX3hhlIT4Lr0Xl849606	rigid:gk5PqAXtRNrPZv3zfxGGlF8ZtgU	false	mutation disrupting interaction strength:1657-1657|mutation disrupting interaction strength:1691-1691|sufficient binding region:1432-1770(IPR013016)	sufficient binding region:80-157|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05161	uniprotkb:K0BWD0	intact:EBI-746466|uniprotkb:Q7Z2G2|uniprotkb:Q96GF0|intact:EBI-1056284|uniprotkb:Q5SVA4|ensembl:ENSP00000496832	intact:EBI-25565992	psi-mi:isg15_human(display_long)|uniprotkb:ISG15(gene name)|psi-mi:ISG15(display_short)|uniprotkb:G1P2(gene name synonym)|uniprotkb:UCRP(gene name synonym)|uniprotkb:Interferon-induced 15 kDa protein(gene name synonym)|uniprotkb:Interferon-induced 17 kDa protein(gene name synonym)|uniprotkb:Ubiquitin cross-reactive protein(gene name synonym)	psi-mi:k0bwd0_mers(display_long)|uniprotkb:orf1ab(gene name)|psi-mi:orf1ab(display_short)|uniprotkb:3C-like proteinase(gene name synonym)|uniprotkb:Growth factor-like peptide(gene name synonym)|uniprotkb:Guanine-N7 methyltransferase(gene name synonym)|uniprotkb:Helicase(gene name synonym)|uniprotkb:Host translation inhibitor nsp1(gene name synonym)|uniprotkb:Leader protein(gene name synonym)|uniprotkb:NendoU(gene name synonym)|uniprotkb:Non-structural protein 10(gene name synonym)|uniprotkb:Non-structural protein 2(gene name synonym)|uniprotkb:Non-structural protein 3(gene name synonym)|uniprotkb:Non-structural protein 4(gene name synonym)|uniprotkb:Non-structural protein 6(gene name synonym)|uniprotkb:Non-structural protein 7(gene name synonym)|uniprotkb:Non-structural protein 8(gene name synonym)|uniprotkb:Non-structural protein 9(gene name synonym)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:Papain-like proteinase(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym)|uniprotkb:Uridylate-specific endoribonuclease(gene name synonym)|uniprotkb:nsp5(gene name synonym)|uniprotkb:p65 homolog(gene name synonym)|uniprotkb:nsp12(gene name synonym)|uniprotkb:nsp14(gene name synonym)|uniprotkb:nsp15(gene name synonym)|uniprotkb:nsp13(gene name synonym)|uniprotkb:nsp16(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Daczkowski et al. (2017)	pubmed:28931677|imex:IM-27920	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:1235996(cv2ce)|taxid:1235996(Human betacoronavirus 2c EMC/2012)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25566317|imex:IM-27920-3|pdbe:5W8U	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005092.1|ensembl:ENSG00000187608(gene)|ensembl:ENST00000649529(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009615"(response to virus)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031386"(protein tag)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032020"(ISG15-protein conjugation)|go:"GO:0032461"(positive regulation of protein oligomerization)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034340"(response to type I interferon)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0070585"(protein localization to mitochondrion)|interpro:IPR000626(Ubiquitin)|interpro:IPR019956|interpro:IPR029071|mint:P05161|rcsb pdb:1Z2M|rcsb pdb:2HJ8|rcsb pdb:3PHX|rcsb pdb:3PSE|rcsb pdb:3R66|rcsb pdb:3RT3|rcsb pdb:3SDL|rcsb pdb:5TL6|rcsb pdb:5W8T|rcsb pdb:5W8U|rcsb pdb:6BI8|rcsb pdb:6FFA|rcsb pdb:6XA9|reactome:R-HSA-1169408|reactome:R-HSA-168276|reactome:R-HSA-168928|reactome:R-HSA-5656169|reactome:R-HSA-909733|reactome:R-HSA-936440|dip:DIP-29814N	go:"GO:0005524"(ATP binding)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0032259"(methylation)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|interpro:IPR022733|interpro:IPR044315|interpro:IPR044327|interpro:IPR044330|rcsb pdb:4P16|rcsb pdb:5V69|rcsb pdb:5V6A|rcsb pdb:5WWP|rcsb pdb:5YN5|rcsb pdb:5YN6|rcsb pdb:5YN8|rcsb pdb:5YNB|rcsb pdb:5YNF|rcsb pdb:5YNI|rcsb pdb:5YNJ|rcsb pdb:5YNM|rcsb pdb:5YNN|rcsb pdb:5YNO|rcsb pdb:5YNP|rcsb pdb:5YNQ|rcsb pdb:6BI8|interpro:IPR027351|interpro:IPR032505|interpro:IPR009461(Coronavirus NSP13)|interpro:IPR027352|interpro:IPR041679|interpro:IPR037227|interpro:IPR002589(Appr-1-p processing)|interpro:IPR032592|interpro:IPR042570|interpro:IPR036333|interpro:IPR009466(NSP11)|interpro:IPR042515|interpro:IPR024375|interpro:IPR038400|interpro:IPR038123|interpro:IPR014828(Nsp7 replicase)|interpro:IPR037204|interpro:IPR014829(Nsp8 replicase)|interpro:IPR037230|interpro:IPR014822(Nsp9 replicase)|interpro:IPR036499|interpro:IPR027417|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR038083|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR009469(RNA polymerase, N-terminal, coronaviral)|interpro:IPR018995|interpro:IPR029063|interpro:IPR043174|interpro:IPR043177|interpro:IPR043178|interpro:IPR043472|interpro:IPR043477|interpro:IPR043502|interpro:IPR043503|interpro:IPR043504|interpro:IPR021590|interpro:IPR043606|interpro:IPR043608|interpro:IPR043609|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|interpro:IPR044343|interpro:IPR044350|interpro:IPR044353|interpro:IPR044357|interpro:IPR044367|interpro:IPR044371|interpro:IPR044382|interpro:IPR044388|interpro:IPR044401|ddbj/embl/genbank:AFS88944(identity)	pdbe:5W8T(see-also)	-	-	figure legend:Table 2|3d-resolution:2.41Å|3d-r-factors:"Rwork: 0.212  Rfree: 0.237"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/04/16	2020/04/21	rogid:k01VuKv72XNTX3hhlIT4Lr0Xl849606	rogid:u9TWbKf58gKvK2U0hDw6YNZrBo81235996	rigid:gk5PqAXtRNrPZv3zfxGGlF8ZtgU	false	his tag:c-c|sufficient binding region:80-156	sufficient binding region:1432-1770	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:K0BWD0	uniprotkb:P05161	intact:EBI-25565992	intact:EBI-746466|uniprotkb:Q7Z2G2|uniprotkb:Q96GF0|intact:EBI-1056284|uniprotkb:Q5SVA4|ensembl:ENSP00000496832	psi-mi:k0bwd0_mers(display_long)|uniprotkb:orf1ab(gene name)|psi-mi:orf1ab(display_short)|uniprotkb:3C-like proteinase(gene name synonym)|uniprotkb:Growth factor-like peptide(gene name synonym)|uniprotkb:Guanine-N7 methyltransferase(gene name synonym)|uniprotkb:Helicase(gene name synonym)|uniprotkb:Host translation inhibitor nsp1(gene name synonym)|uniprotkb:Leader protein(gene name synonym)|uniprotkb:NendoU(gene name synonym)|uniprotkb:Non-structural protein 10(gene name synonym)|uniprotkb:Non-structural protein 2(gene name synonym)|uniprotkb:Non-structural protein 3(gene name synonym)|uniprotkb:Non-structural protein 4(gene name synonym)|uniprotkb:Non-structural protein 6(gene name synonym)|uniprotkb:Non-structural protein 7(gene name synonym)|uniprotkb:Non-structural protein 8(gene name synonym)|uniprotkb:Non-structural protein 9(gene name synonym)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:Papain-like proteinase(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym)|uniprotkb:Uridylate-specific endoribonuclease(gene name synonym)|uniprotkb:nsp5(gene name synonym)|uniprotkb:p65 homolog(gene name synonym)|uniprotkb:nsp12(gene name synonym)|uniprotkb:nsp14(gene name synonym)|uniprotkb:nsp15(gene name synonym)|uniprotkb:nsp13(gene name synonym)|uniprotkb:nsp16(gene name synonym)	psi-mi:isg15_human(display_long)|uniprotkb:ISG15(gene name)|psi-mi:ISG15(display_short)|uniprotkb:G1P2(gene name synonym)|uniprotkb:UCRP(gene name synonym)|uniprotkb:Interferon-induced 15 kDa protein(gene name synonym)|uniprotkb:Interferon-induced 17 kDa protein(gene name synonym)|uniprotkb:Ubiquitin cross-reactive protein(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Daczkowski et al. (2017)	pubmed:28931677|imex:IM-27920	taxid:1235996(cv2ce)|taxid:1235996(Human betacoronavirus 2c EMC/2012)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25566601|imex:IM-27920-5	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005524"(ATP binding)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0032259"(methylation)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|interpro:IPR022733|interpro:IPR044315|interpro:IPR044327|interpro:IPR044330|rcsb pdb:4P16|rcsb pdb:5V69|rcsb pdb:5V6A|rcsb pdb:5WWP|rcsb pdb:5YN5|rcsb pdb:5YN6|rcsb pdb:5YN8|rcsb pdb:5YNB|rcsb pdb:5YNF|rcsb pdb:5YNI|rcsb pdb:5YNJ|rcsb pdb:5YNM|rcsb pdb:5YNN|rcsb pdb:5YNO|rcsb pdb:5YNP|rcsb pdb:5YNQ|rcsb pdb:6BI8|interpro:IPR027351|interpro:IPR032505|interpro:IPR009461(Coronavirus NSP13)|interpro:IPR027352|interpro:IPR041679|interpro:IPR037227|interpro:IPR002589(Appr-1-p processing)|interpro:IPR032592|interpro:IPR042570|interpro:IPR036333|interpro:IPR009466(NSP11)|interpro:IPR042515|interpro:IPR024375|interpro:IPR038400|interpro:IPR038123|interpro:IPR014828(Nsp7 replicase)|interpro:IPR037204|interpro:IPR014829(Nsp8 replicase)|interpro:IPR037230|interpro:IPR014822(Nsp9 replicase)|interpro:IPR036499|interpro:IPR027417|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR038083|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR009469(RNA polymerase, N-terminal, coronaviral)|interpro:IPR018995|interpro:IPR029063|interpro:IPR043174|interpro:IPR043177|interpro:IPR043178|interpro:IPR043472|interpro:IPR043477|interpro:IPR043502|interpro:IPR043503|interpro:IPR043504|interpro:IPR021590|interpro:IPR043606|interpro:IPR043608|interpro:IPR043609|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|interpro:IPR044343|interpro:IPR044350|interpro:IPR044353|interpro:IPR044357|interpro:IPR044367|interpro:IPR044371|interpro:IPR044382|interpro:IPR044388|interpro:IPR044401	refseq:NP_005092.1|ensembl:ENSG00000187608(gene)|ensembl:ENST00000649529(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009615"(response to virus)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031386"(protein tag)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032020"(ISG15-protein conjugation)|go:"GO:0032461"(positive regulation of protein oligomerization)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034340"(response to type I interferon)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0070585"(protein localization to mitochondrion)|interpro:IPR000626(Ubiquitin)|interpro:IPR019956|interpro:IPR029071|mint:P05161|rcsb pdb:1Z2M|rcsb pdb:2HJ8|rcsb pdb:3PHX|rcsb pdb:3PSE|rcsb pdb:3R66|rcsb pdb:3RT3|rcsb pdb:3SDL|rcsb pdb:5TL6|rcsb pdb:5W8T|rcsb pdb:5W8U|rcsb pdb:6BI8|rcsb pdb:6FFA|rcsb pdb:6XA9|reactome:R-HSA-1169408|reactome:R-HSA-168276|reactome:R-HSA-168928|reactome:R-HSA-5656169|reactome:R-HSA-909733|reactome:R-HSA-936440|dip:DIP-29814N	-	-	-	figure legend:Figs. 6b, 7b, Table 3|comment:Papain-like protease domain range was inferred from the sequence provided in Fig. 1|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kcat:937.2x1^1 ~35.6(second -1)|km:2.19x10^-6 ~0.255(molar)|kd:27.06x10^-6 ~3.04(molar)	2020/04/16	2020/04/23	rogid:u9TWbKf58gKvK2U0hDw6YNZrBo81235996	rogid:k01VuKv72XNTX3hhlIT4Lr0Xl849606	rigid:gk5PqAXtRNrPZv3zfxGGlF8ZtgU	false	mutation increasing interaction rate:1547-1547|mutation increasing interaction rate:1551-1551|mutation with no effect:1608-1608|mutation with no effect:1659-1659|mutation with no effect:1659-1659|mutation increasing interaction rate:1683-1683|mutation decreasing interaction rate:1657-1657|mutation decreasing interaction rate:1657-1657|mutation increasing interaction rate:1706-1706|mutation with no effect:1706-1706|mutation with no effect:1706-1706|mutation with no effect:1708-1708|mutation with no effect:1713-1713|mutation decreasing interaction rate:1713-1713|mutation decreasing interaction rate:1657-1657|mutation disrupting interaction rate:1691-1691|sufficient binding region:1432-1770(IPR013016)|mutation decreasing interaction rate:1715-1715	fluorophore:c-c	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:K0BWD0	uniprotkb:P05161	intact:EBI-25565992	intact:EBI-746466|uniprotkb:Q7Z2G2|uniprotkb:Q96GF0|intact:EBI-1056284|uniprotkb:Q5SVA4|ensembl:ENSP00000496832	psi-mi:k0bwd0_mers(display_long)|uniprotkb:orf1ab(gene name)|psi-mi:orf1ab(display_short)|uniprotkb:3C-like proteinase(gene name synonym)|uniprotkb:Growth factor-like peptide(gene name synonym)|uniprotkb:Guanine-N7 methyltransferase(gene name synonym)|uniprotkb:Helicase(gene name synonym)|uniprotkb:Host translation inhibitor nsp1(gene name synonym)|uniprotkb:Leader protein(gene name synonym)|uniprotkb:NendoU(gene name synonym)|uniprotkb:Non-structural protein 10(gene name synonym)|uniprotkb:Non-structural protein 2(gene name synonym)|uniprotkb:Non-structural protein 3(gene name synonym)|uniprotkb:Non-structural protein 4(gene name synonym)|uniprotkb:Non-structural protein 6(gene name synonym)|uniprotkb:Non-structural protein 7(gene name synonym)|uniprotkb:Non-structural protein 8(gene name synonym)|uniprotkb:Non-structural protein 9(gene name synonym)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:Papain-like proteinase(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym)|uniprotkb:Uridylate-specific endoribonuclease(gene name synonym)|uniprotkb:nsp5(gene name synonym)|uniprotkb:p65 homolog(gene name synonym)|uniprotkb:nsp12(gene name synonym)|uniprotkb:nsp14(gene name synonym)|uniprotkb:nsp15(gene name synonym)|uniprotkb:nsp13(gene name synonym)|uniprotkb:nsp16(gene name synonym)	psi-mi:isg15_human(display_long)|uniprotkb:ISG15(gene name)|psi-mi:ISG15(display_short)|uniprotkb:G1P2(gene name synonym)|uniprotkb:UCRP(gene name synonym)|uniprotkb:Interferon-induced 15 kDa protein(gene name synonym)|uniprotkb:Interferon-induced 17 kDa protein(gene name synonym)|uniprotkb:Ubiquitin cross-reactive protein(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Daczkowski et al. (2017)	pubmed:28931677|imex:IM-27920	taxid:1235996(cv2ce)|taxid:1235996(Human betacoronavirus 2c EMC/2012)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25566648|imex:IM-27920-7	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005524"(ATP binding)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0032259"(methylation)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|interpro:IPR022733|interpro:IPR044315|interpro:IPR044327|interpro:IPR044330|rcsb pdb:4P16|rcsb pdb:5V69|rcsb pdb:5V6A|rcsb pdb:5WWP|rcsb pdb:5YN5|rcsb pdb:5YN6|rcsb pdb:5YN8|rcsb pdb:5YNB|rcsb pdb:5YNF|rcsb pdb:5YNI|rcsb pdb:5YNJ|rcsb pdb:5YNM|rcsb pdb:5YNN|rcsb pdb:5YNO|rcsb pdb:5YNP|rcsb pdb:5YNQ|rcsb pdb:6BI8|interpro:IPR027351|interpro:IPR032505|interpro:IPR009461(Coronavirus NSP13)|interpro:IPR027352|interpro:IPR041679|interpro:IPR037227|interpro:IPR002589(Appr-1-p processing)|interpro:IPR032592|interpro:IPR042570|interpro:IPR036333|interpro:IPR009466(NSP11)|interpro:IPR042515|interpro:IPR024375|interpro:IPR038400|interpro:IPR038123|interpro:IPR014828(Nsp7 replicase)|interpro:IPR037204|interpro:IPR014829(Nsp8 replicase)|interpro:IPR037230|interpro:IPR014822(Nsp9 replicase)|interpro:IPR036499|interpro:IPR027417|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR038083|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR009469(RNA polymerase, N-terminal, coronaviral)|interpro:IPR018995|interpro:IPR029063|interpro:IPR043174|interpro:IPR043177|interpro:IPR043178|interpro:IPR043472|interpro:IPR043477|interpro:IPR043502|interpro:IPR043503|interpro:IPR043504|interpro:IPR021590|interpro:IPR043606|interpro:IPR043608|interpro:IPR043609|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|interpro:IPR044343|interpro:IPR044350|interpro:IPR044353|interpro:IPR044357|interpro:IPR044367|interpro:IPR044371|interpro:IPR044382|interpro:IPR044388|interpro:IPR044401	refseq:NP_005092.1|ensembl:ENSG00000187608(gene)|ensembl:ENST00000649529(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009615"(response to virus)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031386"(protein tag)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032020"(ISG15-protein conjugation)|go:"GO:0032461"(positive regulation of protein oligomerization)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034340"(response to type I interferon)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0070585"(protein localization to mitochondrion)|interpro:IPR000626(Ubiquitin)|interpro:IPR019956|interpro:IPR029071|mint:P05161|rcsb pdb:1Z2M|rcsb pdb:2HJ8|rcsb pdb:3PHX|rcsb pdb:3PSE|rcsb pdb:3R66|rcsb pdb:3RT3|rcsb pdb:3SDL|rcsb pdb:5TL6|rcsb pdb:5W8T|rcsb pdb:5W8U|rcsb pdb:6BI8|rcsb pdb:6FFA|rcsb pdb:6XA9|reactome:R-HSA-1169408|reactome:R-HSA-168276|reactome:R-HSA-168928|reactome:R-HSA-5656169|reactome:R-HSA-909733|reactome:R-HSA-936440|dip:DIP-29814N	-	-	-	figure legend:Fig. 8A|comment:Papain-like protease domain range was inferred from the sequence provided in Fig. 1|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:27.06x10^-6 ~3.04(molar)	2020/04/16	2020/04/22	rogid:u9TWbKf58gKvK2U0hDw6YNZrBo81235996	rogid:k01VuKv72XNTX3hhlIT4Lr0Xl849606	rigid:gk5PqAXtRNrPZv3zfxGGlF8ZtgU	false	mutation decreasing interaction rate:1657-1657|mutation decreasing interaction rate:1691-1691|sufficient binding region:1432-1770(IPR013016)	sufficient binding region:158-165|his tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:R9QB93	uniprotkb:K0BWD0	intact:EBI-25568326	intact:EBI-25565992	psi-mi:r9qb93_tupbe(display_long)	psi-mi:k0bwd0_mers(display_long)|uniprotkb:orf1ab(gene name)|psi-mi:orf1ab(display_short)|uniprotkb:3C-like proteinase(gene name synonym)|uniprotkb:Growth factor-like peptide(gene name synonym)|uniprotkb:Guanine-N7 methyltransferase(gene name synonym)|uniprotkb:Helicase(gene name synonym)|uniprotkb:Host translation inhibitor nsp1(gene name synonym)|uniprotkb:Leader protein(gene name synonym)|uniprotkb:NendoU(gene name synonym)|uniprotkb:Non-structural protein 10(gene name synonym)|uniprotkb:Non-structural protein 2(gene name synonym)|uniprotkb:Non-structural protein 3(gene name synonym)|uniprotkb:Non-structural protein 4(gene name synonym)|uniprotkb:Non-structural protein 6(gene name synonym)|uniprotkb:Non-structural protein 7(gene name synonym)|uniprotkb:Non-structural protein 8(gene name synonym)|uniprotkb:Non-structural protein 9(gene name synonym)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:Papain-like proteinase(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym)|uniprotkb:Uridylate-specific endoribonuclease(gene name synonym)|uniprotkb:nsp5(gene name synonym)|uniprotkb:p65 homolog(gene name synonym)|uniprotkb:nsp12(gene name synonym)|uniprotkb:nsp14(gene name synonym)|uniprotkb:nsp15(gene name synonym)|uniprotkb:nsp13(gene name synonym)|uniprotkb:nsp16(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Daczkowski et al. (2017)	pubmed:28931677|imex:IM-27920	taxid:37347(Common tree shrew)|taxid:37347(Tupaia belangeri)	taxid:1235996(cv2ce)|taxid:1235996(Human betacoronavirus 2c EMC/2012)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25568298|imex:IM-27920-8	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR019956	go:"GO:0005524"(ATP binding)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0032259"(methylation)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|interpro:IPR022733|interpro:IPR044315|interpro:IPR044327|interpro:IPR044330|rcsb pdb:4P16|rcsb pdb:5V69|rcsb pdb:5V6A|rcsb pdb:5WWP|rcsb pdb:5YN5|rcsb pdb:5YN6|rcsb pdb:5YN8|rcsb pdb:5YNB|rcsb pdb:5YNF|rcsb pdb:5YNI|rcsb pdb:5YNJ|rcsb pdb:5YNM|rcsb pdb:5YNN|rcsb pdb:5YNO|rcsb pdb:5YNP|rcsb pdb:5YNQ|rcsb pdb:6BI8|interpro:IPR027351|interpro:IPR032505|interpro:IPR009461(Coronavirus NSP13)|interpro:IPR027352|interpro:IPR041679|interpro:IPR037227|interpro:IPR002589(Appr-1-p processing)|interpro:IPR032592|interpro:IPR042570|interpro:IPR036333|interpro:IPR009466(NSP11)|interpro:IPR042515|interpro:IPR024375|interpro:IPR038400|interpro:IPR038123|interpro:IPR014828(Nsp7 replicase)|interpro:IPR037204|interpro:IPR014829(Nsp8 replicase)|interpro:IPR037230|interpro:IPR014822(Nsp9 replicase)|interpro:IPR036499|interpro:IPR027417|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR038083|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR009469(RNA polymerase, N-terminal, coronaviral)|interpro:IPR018995|interpro:IPR029063|interpro:IPR043174|interpro:IPR043177|interpro:IPR043178|interpro:IPR043472|interpro:IPR043477|interpro:IPR043502|interpro:IPR043503|interpro:IPR043504|interpro:IPR021590|interpro:IPR043606|interpro:IPR043608|interpro:IPR043609|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|interpro:IPR044343|interpro:IPR044350|interpro:IPR044353|interpro:IPR044357|interpro:IPR044367|interpro:IPR044371|interpro:IPR044382|interpro:IPR044388|interpro:IPR044401	-	-	-	figure legend:Fig. 5c|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/04/16	2020/04/22	rogid:EtUQOE+B8D5/kQdqp2eNr/ctlek37347	rogid:u9TWbKf58gKvK2U0hDw6YNZrBo81235996	rigid:ZEFDxvgl8kUN+KVj5Yw+Ej809mw	false	mutation increasing interaction rate:144-144|mutation increasing interaction rate:145-145|sufficient binding region:?-?	sufficient binding region:1432-1770(IPR013016)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)