#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P05155	uniprotkb:Q79GN7	intact:EBI-1223454|uniprotkb:Q547W3|uniprotkb:Q59EI5|uniprotkb:Q96FE0|uniprotkb:A6NMU0|uniprotkb:A8KAI9|uniprotkb:B2R6L5|uniprotkb:Q16304|uniprotkb:Q7Z455|uniprotkb:Q9UC49|uniprotkb:Q9UCF9|uniprotkb:B4E1F0|uniprotkb:B4E1H2|ensembl:ENSP00000278407|ensembl:ENSP00000504807	intact:EBI-27104360	psi-mi:ic1_human(display_long)|uniprotkb:SERPING1(gene name)|psi-mi:SERPING1(display_short)|uniprotkb:C1IN(gene name synonym)|uniprotkb:C1NH(gene name synonym)|uniprotkb:C1 esterase inhibitor(gene name synonym)|uniprotkb:C1-inhibiting factor(gene name synonym)|uniprotkb:Serpin G1(gene name synonym)	psi-mi:q79gn7_borpe(display_long)|uniprotkb:vag8(gene name)|psi-mi:vag8(display_short)|uniprotkb:BP2315(locus name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Wang et al. (2017)	pubmed:28742139|imex:IM-29286	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:257313(borpe)|taxid:257313("Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27104358|imex:IM-29286-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000053.2|refseq:NP_001027466.1|dip:DIP-45635N|ensembl:ENSG00000149131(gene)|ensembl:ENST00000278407(transcript)|ensembl:ENST00000676670(transcript)|go:"GO:0001869"(negative regulation of complement activation, lectin pathway)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007568"(aging)|go:"GO:0007596"(blood coagulation)|go:"GO:0008015"(blood circulation)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045087"(innate immune response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR015553(Protease inhibitor I4, serpin C1)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P05155|rcsb pdb:1M6Q|rcsb pdb:2OAY|rcsb pdb:5DU3|rcsb pdb:5DUQ|rcsb pdb:7AKV|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-9657689|reactome:R-HSA-977606	go:"GO:0019867"(outer membrane)|refseq:NP_880953.1|refseq:WP_010930866.1|interpro:IPR005546(Autotransporter beta-domain)|interpro:IPR036709|interpro:IPR006315(Outer membrane autotransporter barrel)|interpro:IPR012332(Phage P22 tailspike)|interpro:IPR011050(Pectin lyase fold/virulence factor)|interpro:IPR004899(Pertactin)|interpro:IPR003991(Pertactin virulence factor, C-terminal)	-	-	-	figure legend:1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/10/11	rogid:Y7cqCZ6Ryz51dsi6jM86EXdfeWc9606	rogid:1PYDfp3AJnkUkhztQL8kyhBPMC0257313	rigid:pkleNDcsdAG7v4dXC1sus18NtRY	false	-	sufficient binding region:16-610(IPR011050)|his tag:n-n	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P05155	uniprotkb:Q79GN7	intact:EBI-1223454|uniprotkb:Q547W3|uniprotkb:Q59EI5|uniprotkb:Q96FE0|uniprotkb:A6NMU0|uniprotkb:A8KAI9|uniprotkb:B2R6L5|uniprotkb:Q16304|uniprotkb:Q7Z455|uniprotkb:Q9UC49|uniprotkb:Q9UCF9|uniprotkb:B4E1F0|uniprotkb:B4E1H2|ensembl:ENSP00000278407|ensembl:ENSP00000504807	intact:EBI-27104360	psi-mi:ic1_human(display_long)|uniprotkb:SERPING1(gene name)|psi-mi:SERPING1(display_short)|uniprotkb:C1IN(gene name synonym)|uniprotkb:C1NH(gene name synonym)|uniprotkb:C1 esterase inhibitor(gene name synonym)|uniprotkb:C1-inhibiting factor(gene name synonym)|uniprotkb:Serpin G1(gene name synonym)	psi-mi:q79gn7_borpe(display_long)|uniprotkb:vag8(gene name)|psi-mi:vag8(display_short)|uniprotkb:BP2315(locus name)	psi-mi:"MI:0071"(molecular sieving)	Wang et al. (2017)	pubmed:28742139|imex:IM-29286	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:257313(borpe)|taxid:257313("Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27104389|imex:IM-29286-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000053.2|refseq:NP_001027466.1|dip:DIP-45635N|ensembl:ENSG00000149131(gene)|ensembl:ENST00000278407(transcript)|ensembl:ENST00000676670(transcript)|go:"GO:0001869"(negative regulation of complement activation, lectin pathway)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007568"(aging)|go:"GO:0007596"(blood coagulation)|go:"GO:0008015"(blood circulation)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045087"(innate immune response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR015553(Protease inhibitor I4, serpin C1)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P05155|rcsb pdb:1M6Q|rcsb pdb:2OAY|rcsb pdb:5DU3|rcsb pdb:5DUQ|rcsb pdb:7AKV|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-9657689|reactome:R-HSA-977606	go:"GO:0019867"(outer membrane)|refseq:NP_880953.1|refseq:WP_010930866.1|interpro:IPR005546(Autotransporter beta-domain)|interpro:IPR036709|interpro:IPR006315(Outer membrane autotransporter barrel)|interpro:IPR012332(Phage P22 tailspike)|interpro:IPR011050(Pectin lyase fold/virulence factor)|interpro:IPR004899(Pertactin)|interpro:IPR003991(Pertactin virulence factor, C-terminal)	-	-	-	figure legend:1B, Supp. figure 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/10/11	rogid:Y7cqCZ6Ryz51dsi6jM86EXdfeWc9606	rogid:1PYDfp3AJnkUkhztQL8kyhBPMC0257313	rigid:pkleNDcsdAG7v4dXC1sus18NtRY	false	-	sufficient binding region:16-610(IPR011050)|his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0113"(western blot)
uniprotkb:P09871	uniprotkb:P05155	intact:EBI-2810045|uniprotkb:Q9UCU9|uniprotkb:Q9UCV3|uniprotkb:Q9UCU7|uniprotkb:Q9UCV5|uniprotkb:Q9UCV4|uniprotkb:Q9UCU8|uniprotkb:Q9UCV2|uniprotkb:Q9UCV1|uniprotkb:Q9UCV0|uniprotkb:Q9UM14|uniprotkb:D3DUT4|ensembl:ENSP00000328173|ensembl:ENSP00000354057|ensembl:ENSP00000385035	intact:EBI-1223454|uniprotkb:Q547W3|uniprotkb:Q59EI5|uniprotkb:Q96FE0|uniprotkb:A6NMU0|uniprotkb:A8KAI9|uniprotkb:B2R6L5|uniprotkb:Q16304|uniprotkb:Q7Z455|uniprotkb:Q9UC49|uniprotkb:Q9UCF9|uniprotkb:B4E1F0|uniprotkb:B4E1H2|ensembl:ENSP00000278407|ensembl:ENSP00000504807	psi-mi:c1s_human(display_long)|uniprotkb:C1S(gene name)|psi-mi:C1S(display_short)|uniprotkb:C1 esterase(gene name synonym)|uniprotkb:Complement component 1 subcomponent s(gene name synonym)	psi-mi:ic1_human(display_long)|uniprotkb:SERPING1(gene name)|psi-mi:SERPING1(display_short)|uniprotkb:C1IN(gene name synonym)|uniprotkb:C1NH(gene name synonym)|uniprotkb:C1 esterase inhibitor(gene name synonym)|uniprotkb:C1-inhibiting factor(gene name synonym)|uniprotkb:Serpin G1(gene name synonym)	psi-mi:"MI:0807"(comigration in gel electrophoresis)	Wang et al. (2017)	pubmed:28742139|imex:IM-29286	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27104407|imex:IM-29286-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001725.1|refseq:NP_958850.1|ensembl:ENSG00000182326(gene)|ensembl:ENST00000328916(transcript)|ensembl:ENST00000360817(transcript)|ensembl:ENST00000406697(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0072562"(blood microparticle)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000859(CUB)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018097|interpro:IPR033116|interpro:IPR035708|interpro:IPR035914|interpro:IPR035976|interpro:IPR043504|rcsb pdb:1ELV|rcsb pdb:1NZI|rcsb pdb:4J1Y|rcsb pdb:4LMF|rcsb pdb:4LOR|rcsb pdb:4LOS|rcsb pdb:4LOT|rcsb pdb:6F1C|rcsb pdb:6F1H|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-977606|refseq:NP_001333779.1|refseq:XP_005253817.1	refseq:NP_000053.2|refseq:NP_001027466.1|dip:DIP-45635N|ensembl:ENSG00000149131(gene)|ensembl:ENST00000278407(transcript)|ensembl:ENST00000676670(transcript)|go:"GO:0001869"(negative regulation of complement activation, lectin pathway)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007568"(aging)|go:"GO:0007596"(blood coagulation)|go:"GO:0008015"(blood circulation)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045087"(innate immune response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR015553(Protease inhibitor I4, serpin C1)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P05155|rcsb pdb:1M6Q|rcsb pdb:2OAY|rcsb pdb:5DU3|rcsb pdb:5DUQ|rcsb pdb:7AKV|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-9657689|reactome:R-HSA-977606	-	-	-	figure legend:5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/10/11	rogid:3zz5RwIqLyPO71zdCp5Vx7aVl+Y9606	rogid:Y7cqCZ6Ryz51dsi6jM86EXdfeWc9606	rigid:o1sZUV+iYvoilaFdt4QzzTX22v0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0113"(western blot)
uniprotkb:P09871	uniprotkb:Q79GN7	intact:EBI-2810045|uniprotkb:Q9UCU9|uniprotkb:Q9UCV3|uniprotkb:Q9UCU7|uniprotkb:Q9UCV5|uniprotkb:Q9UCV4|uniprotkb:Q9UCU8|uniprotkb:Q9UCV2|uniprotkb:Q9UCV1|uniprotkb:Q9UCV0|uniprotkb:Q9UM14|uniprotkb:D3DUT4|ensembl:ENSP00000328173|ensembl:ENSP00000354057|ensembl:ENSP00000385035	intact:EBI-27104360	psi-mi:c1s_human(display_long)|uniprotkb:C1S(gene name)|psi-mi:C1S(display_short)|uniprotkb:C1 esterase(gene name synonym)|uniprotkb:Complement component 1 subcomponent s(gene name synonym)	psi-mi:q79gn7_borpe(display_long)|uniprotkb:vag8(gene name)|psi-mi:vag8(display_short)|uniprotkb:BP2315(locus name)	psi-mi:"MI:0807"(comigration in gel electrophoresis)	Wang et al. (2017)	pubmed:28742139|imex:IM-29286	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:257313(borpe)|taxid:257313("Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27104407|imex:IM-29286-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001725.1|refseq:NP_958850.1|ensembl:ENSG00000182326(gene)|ensembl:ENST00000328916(transcript)|ensembl:ENST00000360817(transcript)|ensembl:ENST00000406697(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0072562"(blood microparticle)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000859(CUB)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018097|interpro:IPR033116|interpro:IPR035708|interpro:IPR035914|interpro:IPR035976|interpro:IPR043504|rcsb pdb:1ELV|rcsb pdb:1NZI|rcsb pdb:4J1Y|rcsb pdb:4LMF|rcsb pdb:4LOR|rcsb pdb:4LOS|rcsb pdb:4LOT|rcsb pdb:6F1C|rcsb pdb:6F1H|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-977606|refseq:NP_001333779.1|refseq:XP_005253817.1	go:"GO:0019867"(outer membrane)|refseq:NP_880953.1|refseq:WP_010930866.1|interpro:IPR005546(Autotransporter beta-domain)|interpro:IPR036709|interpro:IPR006315(Outer membrane autotransporter barrel)|interpro:IPR012332(Phage P22 tailspike)|interpro:IPR011050(Pectin lyase fold/virulence factor)|interpro:IPR004899(Pertactin)|interpro:IPR003991(Pertactin virulence factor, C-terminal)	-	-	-	figure legend:5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/10/11	rogid:3zz5RwIqLyPO71zdCp5Vx7aVl+Y9606	rogid:1PYDfp3AJnkUkhztQL8kyhBPMC0257313	rigid:o1sZUV+iYvoilaFdt4QzzTX22v0	false	-	sufficient binding region:16-610(IPR011050)|his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P09871	uniprotkb:P05155	intact:EBI-2810045|uniprotkb:Q9UCU9|uniprotkb:Q9UCV3|uniprotkb:Q9UCU7|uniprotkb:Q9UCV5|uniprotkb:Q9UCV4|uniprotkb:Q9UCU8|uniprotkb:Q9UCV2|uniprotkb:Q9UCV1|uniprotkb:Q9UCV0|uniprotkb:Q9UM14|uniprotkb:D3DUT4|ensembl:ENSP00000328173|ensembl:ENSP00000354057|ensembl:ENSP00000385035	intact:EBI-1223454|uniprotkb:Q547W3|uniprotkb:Q59EI5|uniprotkb:Q96FE0|uniprotkb:A6NMU0|uniprotkb:A8KAI9|uniprotkb:B2R6L5|uniprotkb:Q16304|uniprotkb:Q7Z455|uniprotkb:Q9UC49|uniprotkb:Q9UCF9|uniprotkb:B4E1F0|uniprotkb:B4E1H2|ensembl:ENSP00000278407|ensembl:ENSP00000504807	psi-mi:c1s_human(display_long)|uniprotkb:C1S(gene name)|psi-mi:C1S(display_short)|uniprotkb:C1 esterase(gene name synonym)|uniprotkb:Complement component 1 subcomponent s(gene name synonym)	psi-mi:ic1_human(display_long)|uniprotkb:SERPING1(gene name)|psi-mi:SERPING1(display_short)|uniprotkb:C1IN(gene name synonym)|uniprotkb:C1NH(gene name synonym)|uniprotkb:C1 esterase inhibitor(gene name synonym)|uniprotkb:C1-inhibiting factor(gene name synonym)|uniprotkb:Serpin G1(gene name synonym)	psi-mi:"MI:0807"(comigration in gel electrophoresis)	Wang et al. (2017)	pubmed:28742139|imex:IM-29286	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27104417|imex:IM-29286-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001725.1|refseq:NP_958850.1|ensembl:ENSG00000182326(gene)|ensembl:ENST00000328916(transcript)|ensembl:ENST00000360817(transcript)|ensembl:ENST00000406697(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0072562"(blood microparticle)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000859(CUB)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018097|interpro:IPR033116|interpro:IPR035708|interpro:IPR035914|interpro:IPR035976|interpro:IPR043504|rcsb pdb:1ELV|rcsb pdb:1NZI|rcsb pdb:4J1Y|rcsb pdb:4LMF|rcsb pdb:4LOR|rcsb pdb:4LOS|rcsb pdb:4LOT|rcsb pdb:6F1C|rcsb pdb:6F1H|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-977606|refseq:NP_001333779.1|refseq:XP_005253817.1	refseq:NP_000053.2|refseq:NP_001027466.1|dip:DIP-45635N|ensembl:ENSG00000149131(gene)|ensembl:ENST00000278407(transcript)|ensembl:ENST00000676670(transcript)|go:"GO:0001869"(negative regulation of complement activation, lectin pathway)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007568"(aging)|go:"GO:0007596"(blood coagulation)|go:"GO:0008015"(blood circulation)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045087"(innate immune response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR015553(Protease inhibitor I4, serpin C1)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P05155|rcsb pdb:1M6Q|rcsb pdb:2OAY|rcsb pdb:5DU3|rcsb pdb:5DUQ|rcsb pdb:7AKV|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-9657689|reactome:R-HSA-977606	-	-	-	figure legend:5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/10/11	rogid:3zz5RwIqLyPO71zdCp5Vx7aVl+Y9606	rogid:Y7cqCZ6Ryz51dsi6jM86EXdfeWc9606	rigid:EaXylrR+UWWU2YD6Ux9pXi2QDMc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0113"(western blot)
uniprotkb:P00736	uniprotkb:P05155	intact:EBI-3926504|uniprotkb:Q8J012|uniprotkb:Q68D77|uniprotkb:A6NJQ8	intact:EBI-1223454|uniprotkb:Q547W3|uniprotkb:Q59EI5|uniprotkb:Q96FE0|uniprotkb:A6NMU0|uniprotkb:A8KAI9|uniprotkb:B2R6L5|uniprotkb:Q16304|uniprotkb:Q7Z455|uniprotkb:Q9UC49|uniprotkb:Q9UCF9|uniprotkb:B4E1F0|uniprotkb:B4E1H2|ensembl:ENSP00000278407|ensembl:ENSP00000504807	psi-mi:c1r_human(display_long)|uniprotkb:C1R(gene name)|psi-mi:C1R(display_short)|uniprotkb:Complement component 1 subcomponent r(gene name synonym)	psi-mi:ic1_human(display_long)|uniprotkb:SERPING1(gene name)|psi-mi:SERPING1(display_short)|uniprotkb:C1IN(gene name synonym)|uniprotkb:C1NH(gene name synonym)|uniprotkb:C1 esterase inhibitor(gene name synonym)|uniprotkb:C1-inhibiting factor(gene name synonym)|uniprotkb:Serpin G1(gene name synonym)	psi-mi:"MI:0807"(comigration in gel electrophoresis)	Wang et al. (2017)	pubmed:28742139|imex:IM-29286	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27104427|imex:IM-29286-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR035914|interpro:IPR035976|rcsb pdb:6F1C|rcsb pdb:6F1D|rcsb pdb:6F1H|refseq:NP_001724.3|interpro:IPR000859(CUB)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR018097|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR000436(Sushi/SCR/CCP)|rcsb pdb:1APQ|rcsb pdb:1GPZ|rcsb pdb:1MD7|rcsb pdb:1MD8|rcsb pdb:2QY0|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0031638"(zymogen activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR033116|rcsb pdb:6F39|interpro:IPR000742(EGF-like, type 3)|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-977606|interpro:IPR035707|interpro:IPR043504	refseq:NP_000053.2|refseq:NP_001027466.1|dip:DIP-45635N|ensembl:ENSG00000149131(gene)|ensembl:ENST00000278407(transcript)|ensembl:ENST00000676670(transcript)|go:"GO:0001869"(negative regulation of complement activation, lectin pathway)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007568"(aging)|go:"GO:0007596"(blood coagulation)|go:"GO:0008015"(blood circulation)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045087"(innate immune response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR015553(Protease inhibitor I4, serpin C1)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P05155|rcsb pdb:1M6Q|rcsb pdb:2OAY|rcsb pdb:5DU3|rcsb pdb:5DUQ|rcsb pdb:7AKV|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-9657689|reactome:R-HSA-977606	-	-	-	figure legend:5 B/C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/10/11	rogid:7E+ASC6Hv3CoXdwfWEMwCtYALbw9606	rogid:Y7cqCZ6Ryz51dsi6jM86EXdfeWc9606	rigid:52dLJEtTix7izzv3et9/L2998LY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0113"(western blot)
uniprotkb:P00736	uniprotkb:Q79GN7	intact:EBI-3926504|uniprotkb:Q8J012|uniprotkb:Q68D77|uniprotkb:A6NJQ8	intact:EBI-27104360	psi-mi:c1r_human(display_long)|uniprotkb:C1R(gene name)|psi-mi:C1R(display_short)|uniprotkb:Complement component 1 subcomponent r(gene name synonym)	psi-mi:q79gn7_borpe(display_long)|uniprotkb:vag8(gene name)|psi-mi:vag8(display_short)|uniprotkb:BP2315(locus name)	psi-mi:"MI:0807"(comigration in gel electrophoresis)	Wang et al. (2017)	pubmed:28742139|imex:IM-29286	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:257313(borpe)|taxid:257313("Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27104427|imex:IM-29286-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR035914|interpro:IPR035976|rcsb pdb:6F1C|rcsb pdb:6F1D|rcsb pdb:6F1H|refseq:NP_001724.3|interpro:IPR000859(CUB)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR018097|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR000436(Sushi/SCR/CCP)|rcsb pdb:1APQ|rcsb pdb:1GPZ|rcsb pdb:1MD7|rcsb pdb:1MD8|rcsb pdb:2QY0|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0031638"(zymogen activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR033116|rcsb pdb:6F39|interpro:IPR000742(EGF-like, type 3)|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-977606|interpro:IPR035707|interpro:IPR043504	go:"GO:0019867"(outer membrane)|refseq:NP_880953.1|refseq:WP_010930866.1|interpro:IPR005546(Autotransporter beta-domain)|interpro:IPR036709|interpro:IPR006315(Outer membrane autotransporter barrel)|interpro:IPR012332(Phage P22 tailspike)|interpro:IPR011050(Pectin lyase fold/virulence factor)|interpro:IPR004899(Pertactin)|interpro:IPR003991(Pertactin virulence factor, C-terminal)	-	-	-	figure legend:5 B/C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/10/11	rogid:7E+ASC6Hv3CoXdwfWEMwCtYALbw9606	rogid:1PYDfp3AJnkUkhztQL8kyhBPMC0257313	rigid:52dLJEtTix7izzv3et9/L2998LY	false	-	sufficient binding region:16-610(IPR011050)|his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P00736	uniprotkb:P05155	intact:EBI-3926504|uniprotkb:Q8J012|uniprotkb:Q68D77|uniprotkb:A6NJQ8	intact:EBI-1223454|uniprotkb:Q547W3|uniprotkb:Q59EI5|uniprotkb:Q96FE0|uniprotkb:A6NMU0|uniprotkb:A8KAI9|uniprotkb:B2R6L5|uniprotkb:Q16304|uniprotkb:Q7Z455|uniprotkb:Q9UC49|uniprotkb:Q9UCF9|uniprotkb:B4E1F0|uniprotkb:B4E1H2|ensembl:ENSP00000278407|ensembl:ENSP00000504807	psi-mi:c1r_human(display_long)|uniprotkb:C1R(gene name)|psi-mi:C1R(display_short)|uniprotkb:Complement component 1 subcomponent r(gene name synonym)	psi-mi:ic1_human(display_long)|uniprotkb:SERPING1(gene name)|psi-mi:SERPING1(display_short)|uniprotkb:C1IN(gene name synonym)|uniprotkb:C1NH(gene name synonym)|uniprotkb:C1 esterase inhibitor(gene name synonym)|uniprotkb:C1-inhibiting factor(gene name synonym)|uniprotkb:Serpin G1(gene name synonym)	psi-mi:"MI:0807"(comigration in gel electrophoresis)	Wang et al. (2017)	pubmed:28742139|imex:IM-29286	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27104437|imex:IM-29286-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR035914|interpro:IPR035976|rcsb pdb:6F1C|rcsb pdb:6F1D|rcsb pdb:6F1H|refseq:NP_001724.3|interpro:IPR000859(CUB)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR018097|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR000436(Sushi/SCR/CCP)|rcsb pdb:1APQ|rcsb pdb:1GPZ|rcsb pdb:1MD7|rcsb pdb:1MD8|rcsb pdb:2QY0|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0031638"(zymogen activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR033116|rcsb pdb:6F39|interpro:IPR000742(EGF-like, type 3)|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-977606|interpro:IPR035707|interpro:IPR043504	refseq:NP_000053.2|refseq:NP_001027466.1|dip:DIP-45635N|ensembl:ENSG00000149131(gene)|ensembl:ENST00000278407(transcript)|ensembl:ENST00000676670(transcript)|go:"GO:0001869"(negative regulation of complement activation, lectin pathway)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007568"(aging)|go:"GO:0007596"(blood coagulation)|go:"GO:0008015"(blood circulation)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045087"(innate immune response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR015553(Protease inhibitor I4, serpin C1)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P05155|rcsb pdb:1M6Q|rcsb pdb:2OAY|rcsb pdb:5DU3|rcsb pdb:5DUQ|rcsb pdb:7AKV|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-9657689|reactome:R-HSA-977606	-	-	-	figure legend:5 B/C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/10/11	rogid:7E+ASC6Hv3CoXdwfWEMwCtYALbw9606	rogid:Y7cqCZ6Ryz51dsi6jM86EXdfeWc9606	rigid:EGRQJ2rtkjkdexH3I1e2ozkHyME	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0113"(western blot)
uniprotkb:P05155	uniprotkb:O00187	intact:EBI-1223454|uniprotkb:Q547W3|uniprotkb:Q59EI5|uniprotkb:Q96FE0|uniprotkb:A6NMU0|uniprotkb:A8KAI9|uniprotkb:B2R6L5|uniprotkb:Q16304|uniprotkb:Q7Z455|uniprotkb:Q9UC49|uniprotkb:Q9UCF9|uniprotkb:B4E1F0|uniprotkb:B4E1H2|ensembl:ENSP00000278407|ensembl:ENSP00000504807	intact:EBI-7965040|uniprotkb:Q9UMV3|intact:MINT-7970114|uniprotkb:Q9ULC7|uniprotkb:Q9Y270|uniprotkb:A8MWJ2|uniprotkb:O75754|uniprotkb:Q96QG4|uniprotkb:Q9UBP3|uniprotkb:Q5TEQ5|uniprotkb:Q5TER0|uniprotkb:Q9H498|uniprotkb:Q9UC48|uniprotkb:A8K458|uniprotkb:Q9H499|uniprotkb:Q9BZH0|ensembl:ENSP00000383690	psi-mi:ic1_human(display_long)|uniprotkb:SERPING1(gene name)|psi-mi:SERPING1(display_short)|uniprotkb:C1IN(gene name synonym)|uniprotkb:C1NH(gene name synonym)|uniprotkb:C1 esterase inhibitor(gene name synonym)|uniprotkb:C1-inhibiting factor(gene name synonym)|uniprotkb:Serpin G1(gene name synonym)	psi-mi:masp2_human(display_long)|uniprotkb:MASP2(gene name)|psi-mi:MASP2(display_short)|uniprotkb:Mannose-binding protein-associated serine protease 2(gene name synonym)|uniprotkb:MBL-associated serine protease 2(gene name synonym)	psi-mi:"MI:0807"(comigration in gel electrophoresis)	Wang et al. (2017)	pubmed:28742139|imex:IM-29286	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27104447|imex:IM-29286-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000053.2|refseq:NP_001027466.1|dip:DIP-45635N|ensembl:ENSG00000149131(gene)|ensembl:ENST00000278407(transcript)|ensembl:ENST00000676670(transcript)|go:"GO:0001869"(negative regulation of complement activation, lectin pathway)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007568"(aging)|go:"GO:0007596"(blood coagulation)|go:"GO:0008015"(blood circulation)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045087"(innate immune response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR015553(Protease inhibitor I4, serpin C1)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P05155|rcsb pdb:1M6Q|rcsb pdb:2OAY|rcsb pdb:5DU3|rcsb pdb:5DUQ|rcsb pdb:7AKV|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-9657689|reactome:R-HSA-977606	refseq:NP_631947.1|refseq:NP_006601.2|ensembl:ENSG00000009724(gene)|ensembl:ENST00000400897(transcript)|go:"GO:0001855"(complement component C4b binding)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008233"(peptidase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000859(CUB)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018097|interpro:IPR033116|interpro:IPR035914|interpro:IPR035976|interpro:IPR037571|interpro:IPR043504|rcsb pdb:1Q3X|rcsb pdb:1SZB|rcsb pdb:1ZJK|rcsb pdb:3TVJ|rcsb pdb:4FXG|rcsb pdb:5JPM|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086	-	-	comment:mint	figure legend:5 D|comment:Primers for MASP2, in Table 2, only map for the 'reverse' sequence.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/10/11	rogid:Y7cqCZ6Ryz51dsi6jM86EXdfeWc9606	rogid:S48IDwjdZ8M6vIJD6iM0XplSN609606	rigid:FCDCnORW7ZgHDi6oiB2DemmaL+g	false	-	his tag:n-n|sufficient binding region:?-296	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05155	uniprotkb:Q79GN7	intact:EBI-1223454|uniprotkb:Q547W3|uniprotkb:Q59EI5|uniprotkb:Q96FE0|uniprotkb:A6NMU0|uniprotkb:A8KAI9|uniprotkb:B2R6L5|uniprotkb:Q16304|uniprotkb:Q7Z455|uniprotkb:Q9UC49|uniprotkb:Q9UCF9|uniprotkb:B4E1F0|uniprotkb:B4E1H2|ensembl:ENSP00000278407|ensembl:ENSP00000504807	intact:EBI-27104360	psi-mi:ic1_human(display_long)|uniprotkb:SERPING1(gene name)|psi-mi:SERPING1(display_short)|uniprotkb:C1IN(gene name synonym)|uniprotkb:C1NH(gene name synonym)|uniprotkb:C1 esterase inhibitor(gene name synonym)|uniprotkb:C1-inhibiting factor(gene name synonym)|uniprotkb:Serpin G1(gene name synonym)	psi-mi:q79gn7_borpe(display_long)|uniprotkb:vag8(gene name)|psi-mi:vag8(display_short)|uniprotkb:BP2315(locus name)	psi-mi:"MI:0807"(comigration in gel electrophoresis)	Wang et al. (2017)	pubmed:28742139|imex:IM-29286	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:257313(borpe)|taxid:257313("Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27104447|imex:IM-29286-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000053.2|refseq:NP_001027466.1|dip:DIP-45635N|ensembl:ENSG00000149131(gene)|ensembl:ENST00000278407(transcript)|ensembl:ENST00000676670(transcript)|go:"GO:0001869"(negative regulation of complement activation, lectin pathway)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007568"(aging)|go:"GO:0007596"(blood coagulation)|go:"GO:0008015"(blood circulation)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045087"(innate immune response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR015553(Protease inhibitor I4, serpin C1)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P05155|rcsb pdb:1M6Q|rcsb pdb:2OAY|rcsb pdb:5DU3|rcsb pdb:5DUQ|rcsb pdb:7AKV|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-9657689|reactome:R-HSA-977606	go:"GO:0019867"(outer membrane)|refseq:NP_880953.1|refseq:WP_010930866.1|interpro:IPR005546(Autotransporter beta-domain)|interpro:IPR036709|interpro:IPR006315(Outer membrane autotransporter barrel)|interpro:IPR012332(Phage P22 tailspike)|interpro:IPR011050(Pectin lyase fold/virulence factor)|interpro:IPR004899(Pertactin)|interpro:IPR003991(Pertactin virulence factor, C-terminal)	-	-	-	figure legend:5 D|comment:Primers for MASP2, in Table 2, only map for the 'reverse' sequence.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/10/11	rogid:Y7cqCZ6Ryz51dsi6jM86EXdfeWc9606	rogid:1PYDfp3AJnkUkhztQL8kyhBPMC0257313	rigid:FCDCnORW7ZgHDi6oiB2DemmaL+g	false	-	sufficient binding region:16-610(IPR011050)|his tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0396"(predetermined participant)
matrixdb:MULT_83_human	uniprotkb:P09871	intact:EBI-6269273|reactome:R-HSA-173584|reactome:R-HSA-173615|reactome:R-HSA-173617|intenz:3.4.21.42|intenz:3.4.21.41	intact:EBI-2810045|uniprotkb:Q9UCU9|uniprotkb:Q9UCV3|uniprotkb:Q9UCU7|uniprotkb:Q9UCV5|uniprotkb:Q9UCV4|uniprotkb:Q9UCU8|uniprotkb:Q9UCV2|uniprotkb:Q9UCV1|uniprotkb:Q9UCV0|uniprotkb:Q9UM14|uniprotkb:D3DUT4|ensembl:ENSP00000328173|ensembl:ENSP00000354057|ensembl:ENSP00000385035	psi-mi:c1_human(display_short)|psi-mi:MULT_83_human(display_long)|intact:Complement C1 complex(complex recommended name)|intact:"6xC1QA:6xC1QB:6xC1QC:2xC1R:2xC1S"(complex systematic name)	psi-mi:c1s_human(display_long)|uniprotkb:C1S(gene name)|psi-mi:C1S(display_short)|uniprotkb:C1 esterase(gene name synonym)|uniprotkb:Complement component 1 subcomponent s(gene name synonym)	psi-mi:"MI:0807"(comigration in gel electrophoresis)	Wang et al. (2017)	pubmed:28742139|imex:IM-29286	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27104538|imex:IM-29286-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	efo:"MONDO:0013419"(see-also)|wwpdb:2wnv(subset)|go:"GO:0005576"(extracellular region)|wwpdb:1PK6(subset)|wwpdb:2jg8(subset)|wwpdb:2jg9(subset)|wwpdb:2wnu(subset)|evidence ontology:"ECO:0005547"|efo:"MONDO:0013343"(see-also)|wwpdb:4LOR(subset)|complex portal:CPX-1920(complex-primary)|wwpdb:6F1C(subset)|pubmed:6250896(see-also)|pubmed:11527969(see-also)|pubmed:28104818(see-also)|go:"GO:0005602"(complement component C1 complex)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0005509"(calcium ion binding)|wwpdb:2QY0(subset)|efo:"Orphanet:75392"(see-also)|pubmed:29311313(see-also)|pubmed:26489954(see-also)	refseq:NP_001725.1|refseq:NP_958850.1|ensembl:ENSG00000182326(gene)|ensembl:ENST00000328916(transcript)|ensembl:ENST00000360817(transcript)|ensembl:ENST00000406697(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0072562"(blood microparticle)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000859(CUB)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018097|interpro:IPR033116|interpro:IPR035708|interpro:IPR035914|interpro:IPR035976|interpro:IPR043504|rcsb pdb:1ELV|rcsb pdb:1NZI|rcsb pdb:4J1Y|rcsb pdb:4LMF|rcsb pdb:4LOR|rcsb pdb:4LOS|rcsb pdb:4LOT|rcsb pdb:6F1C|rcsb pdb:6F1H|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-977606|refseq:NP_001333779.1|refseq:XP_005253817.1	-	complex-assembly:Hetero 22-mer|disease:"Complement component C1q deficiency (C1QD) [MONDO:0013343]: a disorder caused by impaired activation of the complement classical pathway. It generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis."|disease:"Ehlers-Danlos syndrome, periodontal type (EDSPD) [Orphanet:75392]: a form of Ehlers-Danlos syndrome, a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDSPD1 is characterized by the association of typical features of Ehlers-Danlos syndrome with gingival recession and severe early-onset periodontal disease, leading to premature loss of permanent teeth."|disease:"Complement component C1s deficiency [MONDO:0013419]: A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis."|curated-complex:"The first component of the classical serum complement system. In the presence of calcium, the C1q complex (CPX-1919) associates with the C1S-C1R-C1R-C1S tetramer. When C1q binds to an activating target, a conformational change triggers the auto-activation of the associated C1R protease (converting the pro-enzyme into an activated form), which activates C1S. C1S then cleaves the Arg-|-Ala bond in complement component C4 to form C4a and C4b, and the Lys(or Arg)-|-Lys bond in complement component C2 to form C2a and C2b which in turn form C3 convertase complexes C4bC2a-A (CPX-5675) and C4bC2a-B."|complex-properties:2xC1R-2xC1S adopts an extended structure in solution in which the two C1R-C1S dimers are linked by a central interaction between the catalytic domains of C1R. Dimer formation is calcium-dependent, with each heterodimer binding a total of six Ca2+, with a single Ca2+ in each domain. It folds to form a more compact structure to bind to the six collagenous stems of the C1q complex.	-	figure legend:Supp. figure 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/10/11	-	rogid:3zz5RwIqLyPO71zdCp5Vx7aVl+Y9606	-	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0396"(predetermined participant)
matrixdb:MULT_83_human	uniprotkb:Q79GN7	intact:EBI-6269273|reactome:R-HSA-173584|reactome:R-HSA-173615|reactome:R-HSA-173617|intenz:3.4.21.42|intenz:3.4.21.41	intact:EBI-27104360	psi-mi:c1_human(display_short)|psi-mi:MULT_83_human(display_long)|intact:Complement C1 complex(complex recommended name)|intact:"6xC1QA:6xC1QB:6xC1QC:2xC1R:2xC1S"(complex systematic name)	psi-mi:q79gn7_borpe(display_long)|uniprotkb:vag8(gene name)|psi-mi:vag8(display_short)|uniprotkb:BP2315(locus name)	psi-mi:"MI:0807"(comigration in gel electrophoresis)	Wang et al. (2017)	pubmed:28742139|imex:IM-29286	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:257313(borpe)|taxid:257313("Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27104538|imex:IM-29286-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	efo:"MONDO:0013419"(see-also)|wwpdb:2wnv(subset)|go:"GO:0005576"(extracellular region)|wwpdb:1PK6(subset)|wwpdb:2jg8(subset)|wwpdb:2jg9(subset)|wwpdb:2wnu(subset)|evidence ontology:"ECO:0005547"|efo:"MONDO:0013343"(see-also)|wwpdb:4LOR(subset)|complex portal:CPX-1920(complex-primary)|wwpdb:6F1C(subset)|pubmed:6250896(see-also)|pubmed:11527969(see-also)|pubmed:28104818(see-also)|go:"GO:0005602"(complement component C1 complex)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0005509"(calcium ion binding)|wwpdb:2QY0(subset)|efo:"Orphanet:75392"(see-also)|pubmed:29311313(see-also)|pubmed:26489954(see-also)	go:"GO:0019867"(outer membrane)|refseq:NP_880953.1|refseq:WP_010930866.1|interpro:IPR005546(Autotransporter beta-domain)|interpro:IPR036709|interpro:IPR006315(Outer membrane autotransporter barrel)|interpro:IPR012332(Phage P22 tailspike)|interpro:IPR011050(Pectin lyase fold/virulence factor)|interpro:IPR004899(Pertactin)|interpro:IPR003991(Pertactin virulence factor, C-terminal)	-	complex-assembly:Hetero 22-mer|disease:"Complement component C1q deficiency (C1QD) [MONDO:0013343]: a disorder caused by impaired activation of the complement classical pathway. It generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis."|disease:"Ehlers-Danlos syndrome, periodontal type (EDSPD) [Orphanet:75392]: a form of Ehlers-Danlos syndrome, a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDSPD1 is characterized by the association of typical features of Ehlers-Danlos syndrome with gingival recession and severe early-onset periodontal disease, leading to premature loss of permanent teeth."|disease:"Complement component C1s deficiency [MONDO:0013419]: A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis."|curated-complex:"The first component of the classical serum complement system. In the presence of calcium, the C1q complex (CPX-1919) associates with the C1S-C1R-C1R-C1S tetramer. When C1q binds to an activating target, a conformational change triggers the auto-activation of the associated C1R protease (converting the pro-enzyme into an activated form), which activates C1S. C1S then cleaves the Arg-|-Ala bond in complement component C4 to form C4a and C4b, and the Lys(or Arg)-|-Lys bond in complement component C2 to form C2a and C2b which in turn form C3 convertase complexes C4bC2a-A (CPX-5675) and C4bC2a-B."|complex-properties:2xC1R-2xC1S adopts an extended structure in solution in which the two C1R-C1S dimers are linked by a central interaction between the catalytic domains of C1R. Dimer formation is calcium-dependent, with each heterodimer binding a total of six Ca2+, with a single Ca2+ in each domain. It folds to form a more compact structure to bind to the six collagenous stems of the C1q complex.	-	figure legend:Supp. figure 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/10/11	-	rogid:1PYDfp3AJnkUkhztQL8kyhBPMC0257313	-	false	-	sufficient binding region:16-610(IPR011050)|his tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0396"(predetermined participant)
matrixdb:MULT_83_human	uniprotkb:P09871	intact:EBI-6269273|reactome:R-HSA-173584|reactome:R-HSA-173615|reactome:R-HSA-173617|intenz:3.4.21.42|intenz:3.4.21.41	intact:EBI-2810045|uniprotkb:Q9UCU9|uniprotkb:Q9UCV3|uniprotkb:Q9UCU7|uniprotkb:Q9UCV5|uniprotkb:Q9UCV4|uniprotkb:Q9UCU8|uniprotkb:Q9UCV2|uniprotkb:Q9UCV1|uniprotkb:Q9UCV0|uniprotkb:Q9UM14|uniprotkb:D3DUT4|ensembl:ENSP00000328173|ensembl:ENSP00000354057|ensembl:ENSP00000385035	psi-mi:c1_human(display_short)|psi-mi:MULT_83_human(display_long)|intact:Complement C1 complex(complex recommended name)|intact:"6xC1QA:6xC1QB:6xC1QC:2xC1R:2xC1S"(complex systematic name)	psi-mi:c1s_human(display_long)|uniprotkb:C1S(gene name)|psi-mi:C1S(display_short)|uniprotkb:C1 esterase(gene name synonym)|uniprotkb:Complement component 1 subcomponent s(gene name synonym)	psi-mi:"MI:0807"(comigration in gel electrophoresis)	Wang et al. (2017)	pubmed:28742139|imex:IM-29286	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27104549|imex:IM-29286-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	efo:"MONDO:0013419"(see-also)|wwpdb:2wnv(subset)|go:"GO:0005576"(extracellular region)|wwpdb:1PK6(subset)|wwpdb:2jg8(subset)|wwpdb:2jg9(subset)|wwpdb:2wnu(subset)|evidence ontology:"ECO:0005547"|efo:"MONDO:0013343"(see-also)|wwpdb:4LOR(subset)|complex portal:CPX-1920(complex-primary)|wwpdb:6F1C(subset)|pubmed:6250896(see-also)|pubmed:11527969(see-also)|pubmed:28104818(see-also)|go:"GO:0005602"(complement component C1 complex)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0005509"(calcium ion binding)|wwpdb:2QY0(subset)|efo:"Orphanet:75392"(see-also)|pubmed:29311313(see-also)|pubmed:26489954(see-also)	refseq:NP_001725.1|refseq:NP_958850.1|ensembl:ENSG00000182326(gene)|ensembl:ENST00000328916(transcript)|ensembl:ENST00000360817(transcript)|ensembl:ENST00000406697(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0072562"(blood microparticle)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000859(CUB)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018097|interpro:IPR033116|interpro:IPR035708|interpro:IPR035914|interpro:IPR035976|interpro:IPR043504|rcsb pdb:1ELV|rcsb pdb:1NZI|rcsb pdb:4J1Y|rcsb pdb:4LMF|rcsb pdb:4LOR|rcsb pdb:4LOS|rcsb pdb:4LOT|rcsb pdb:6F1C|rcsb pdb:6F1H|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-977606|refseq:NP_001333779.1|refseq:XP_005253817.1	-	complex-assembly:Hetero 22-mer|disease:"Complement component C1q deficiency (C1QD) [MONDO:0013343]: a disorder caused by impaired activation of the complement classical pathway. It generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis."|disease:"Ehlers-Danlos syndrome, periodontal type (EDSPD) [Orphanet:75392]: a form of Ehlers-Danlos syndrome, a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDSPD1 is characterized by the association of typical features of Ehlers-Danlos syndrome with gingival recession and severe early-onset periodontal disease, leading to premature loss of permanent teeth."|disease:"Complement component C1s deficiency [MONDO:0013419]: A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis."|curated-complex:"The first component of the classical serum complement system. In the presence of calcium, the C1q complex (CPX-1919) associates with the C1S-C1R-C1R-C1S tetramer. When C1q binds to an activating target, a conformational change triggers the auto-activation of the associated C1R protease (converting the pro-enzyme into an activated form), which activates C1S. C1S then cleaves the Arg-|-Ala bond in complement component C4 to form C4a and C4b, and the Lys(or Arg)-|-Lys bond in complement component C2 to form C2a and C2b which in turn form C3 convertase complexes C4bC2a-A (CPX-5675) and C4bC2a-B."|complex-properties:2xC1R-2xC1S adopts an extended structure in solution in which the two C1R-C1S dimers are linked by a central interaction between the catalytic domains of C1R. Dimer formation is calcium-dependent, with each heterodimer binding a total of six Ca2+, with a single Ca2+ in each domain. It folds to form a more compact structure to bind to the six collagenous stems of the C1q complex.	-	figure legend:Supp. figure 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/10/11	-	rogid:3zz5RwIqLyPO71zdCp5Vx7aVl+Y9606	-	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00187	uniprotkb:P05155	intact:EBI-7965040|uniprotkb:Q9UMV3|intact:MINT-7970114|uniprotkb:Q9ULC7|uniprotkb:Q9Y270|uniprotkb:A8MWJ2|uniprotkb:O75754|uniprotkb:Q96QG4|uniprotkb:Q9UBP3|uniprotkb:Q5TEQ5|uniprotkb:Q5TER0|uniprotkb:Q9H498|uniprotkb:Q9UC48|uniprotkb:A8K458|uniprotkb:Q9H499|uniprotkb:Q9BZH0|ensembl:ENSP00000383690	intact:EBI-1223454|uniprotkb:Q547W3|uniprotkb:Q59EI5|uniprotkb:Q96FE0|uniprotkb:A6NMU0|uniprotkb:A8KAI9|uniprotkb:B2R6L5|uniprotkb:Q16304|uniprotkb:Q7Z455|uniprotkb:Q9UC49|uniprotkb:Q9UCF9|uniprotkb:B4E1F0|uniprotkb:B4E1H2|ensembl:ENSP00000278407|ensembl:ENSP00000504807	psi-mi:masp2_human(display_long)|uniprotkb:MASP2(gene name)|psi-mi:MASP2(display_short)|uniprotkb:Mannose-binding protein-associated serine protease 2(gene name synonym)|uniprotkb:MBL-associated serine protease 2(gene name synonym)	psi-mi:ic1_human(display_long)|uniprotkb:SERPING1(gene name)|psi-mi:SERPING1(display_short)|uniprotkb:C1IN(gene name synonym)|uniprotkb:C1NH(gene name synonym)|uniprotkb:C1 esterase inhibitor(gene name synonym)|uniprotkb:C1-inhibiting factor(gene name synonym)|uniprotkb:Serpin G1(gene name synonym)	psi-mi:"MI:0807"(comigration in gel electrophoresis)	Wang et al. (2017)	pubmed:28742139|imex:IM-29286	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27122544|imex:IM-29286-24	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_631947.1|refseq:NP_006601.2|ensembl:ENSG00000009724(gene)|ensembl:ENST00000400897(transcript)|go:"GO:0001855"(complement component C4b binding)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008233"(peptidase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000859(CUB)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018097|interpro:IPR033116|interpro:IPR035914|interpro:IPR035976|interpro:IPR037571|interpro:IPR043504|rcsb pdb:1Q3X|rcsb pdb:1SZB|rcsb pdb:1ZJK|rcsb pdb:3TVJ|rcsb pdb:4FXG|rcsb pdb:5JPM|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086	refseq:NP_000053.2|refseq:NP_001027466.1|dip:DIP-45635N|ensembl:ENSG00000149131(gene)|ensembl:ENST00000278407(transcript)|ensembl:ENST00000676670(transcript)|go:"GO:0001869"(negative regulation of complement activation, lectin pathway)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007568"(aging)|go:"GO:0007596"(blood coagulation)|go:"GO:0008015"(blood circulation)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045087"(innate immune response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR015553(Protease inhibitor I4, serpin C1)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P05155|rcsb pdb:1M6Q|rcsb pdb:2OAY|rcsb pdb:5DU3|rcsb pdb:5DUQ|rcsb pdb:7AKV|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-9657689|reactome:R-HSA-977606	-	comment:mint	-	figure legend:5 D|comment:Primers for MASP2, in Table 2, only map for the 'reverse' sequence.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/11/09	rogid:S48IDwjdZ8M6vIJD6iM0XplSN609606	rogid:Y7cqCZ6Ryz51dsi6jM86EXdfeWc9606	rigid:ImSdA+Cbw+hSN5HdivMUOj2dThc	false	his tag:n-n|sufficient binding region:?-296	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0113"(western blot)
uniprotkb:P09871	uniprotkb:P06681	intact:EBI-2810045|uniprotkb:Q9UCU9|uniprotkb:Q9UCV3|uniprotkb:Q9UCU7|uniprotkb:Q9UCV5|uniprotkb:Q9UCV4|uniprotkb:Q9UCU8|uniprotkb:Q9UCV2|uniprotkb:Q9UCV1|uniprotkb:Q9UCV0|uniprotkb:Q9UM14|uniprotkb:D3DUT4|ensembl:ENSP00000328173|ensembl:ENSP00000354057|ensembl:ENSP00000385035	intact:EBI-2835920|uniprotkb:Q13904|uniprotkb:O19694|uniprotkb:B4DPF3|uniprotkb:B4DV20|uniprotkb:E9PFN7|ensembl:ENSP00000299367|ensembl:ENSP00000364660|ensembl:ENSP00000372853|ensembl:ENSP00000392835|ensembl:ENSP00000402278|ensembl:ENSP00000405800|ensembl:ENSP00000407961	psi-mi:c1s_human(display_long)|uniprotkb:C1S(gene name)|psi-mi:C1S(display_short)|uniprotkb:C1 esterase(gene name synonym)|uniprotkb:Complement component 1 subcomponent s(gene name synonym)	psi-mi:co2_human(display_long)|uniprotkb:C2(gene name)|psi-mi:C2(display_short)|uniprotkb:C3/C5 convertase(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Wang et al. (2017)	pubmed:28742139|imex:IM-29286	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27104478|imex:IM-29286-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001725.1|refseq:NP_958850.1|ensembl:ENSG00000182326(gene)|ensembl:ENST00000328916(transcript)|ensembl:ENST00000360817(transcript)|ensembl:ENST00000406697(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0072562"(blood microparticle)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000859(CUB)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018097|interpro:IPR033116|interpro:IPR035708|interpro:IPR035914|interpro:IPR035976|interpro:IPR043504|rcsb pdb:1ELV|rcsb pdb:1NZI|rcsb pdb:4J1Y|rcsb pdb:4LMF|rcsb pdb:4LOR|rcsb pdb:4LOS|rcsb pdb:4LOT|rcsb pdb:6F1C|rcsb pdb:6F1H|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-977606|refseq:NP_001333779.1|refseq:XP_005253817.1	refseq:NP_001139375.1|refseq:NP_000054.2|refseq:NP_001171534.1|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR011360(Complement B/C2)|interpro:IPR018114|interpro:IPR033116|interpro:IPR035976|interpro:IPR036465|interpro:IPR037568|interpro:IPR043504|rcsb pdb:2I6Q|rcsb pdb:2I6S|rcsb pdb:2ODP|rcsb pdb:2ODQ|rcsb pdb:3ERB|reactome:R-HSA-166663|reactome:R-HSA-174577|reactome:R-HSA-977606|ensembl:ENSG00000166278(gene)|ensembl:ENSG00000204364(gene)|ensembl:ENSG00000206372(gene)|ensembl:ENSG00000226560(gene)|ensembl:ENSG00000231543(gene)|ensembl:ENSG00000235017(gene)|ensembl:ENSG00000235696(gene)|ensembl:ENST00000299367(transcript)|ensembl:ENST00000375510(transcript)|ensembl:ENST00000383362(transcript)|ensembl:ENST00000411803(transcript)|ensembl:ENST00000413548(transcript)|ensembl:ENST00000416252(transcript)|ensembl:ENST00000448206(transcript)	go:"GO:0004252"(serine-type endopeptidase activity)	-	-	figure legend:6A|comment:Addition of Vag8 to a purified system consisting of C1-inh, C1s and C2, results in increased cleavage of C2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/10/11	rogid:3zz5RwIqLyPO71zdCp5Vx7aVl+Y9606	rogid:s5wfD0ZDalMI127hnwt8t8ozbY09606	rigid:PQUKSkwKtf6FcGQgpPwYu3nLcMA	false	-	-	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:P09871	uniprotkb:P05155	intact:EBI-2810045|uniprotkb:Q9UCU9|uniprotkb:Q9UCV3|uniprotkb:Q9UCU7|uniprotkb:Q9UCV5|uniprotkb:Q9UCV4|uniprotkb:Q9UCU8|uniprotkb:Q9UCV2|uniprotkb:Q9UCV1|uniprotkb:Q9UCV0|uniprotkb:Q9UM14|uniprotkb:D3DUT4|ensembl:ENSP00000328173|ensembl:ENSP00000354057|ensembl:ENSP00000385035	intact:EBI-1223454|uniprotkb:Q547W3|uniprotkb:Q59EI5|uniprotkb:Q96FE0|uniprotkb:A6NMU0|uniprotkb:A8KAI9|uniprotkb:B2R6L5|uniprotkb:Q16304|uniprotkb:Q7Z455|uniprotkb:Q9UC49|uniprotkb:Q9UCF9|uniprotkb:B4E1F0|uniprotkb:B4E1H2|ensembl:ENSP00000278407|ensembl:ENSP00000504807	psi-mi:c1s_human(display_long)|uniprotkb:C1S(gene name)|psi-mi:C1S(display_short)|uniprotkb:C1 esterase(gene name synonym)|uniprotkb:Complement component 1 subcomponent s(gene name synonym)	psi-mi:ic1_human(display_long)|uniprotkb:SERPING1(gene name)|psi-mi:SERPING1(display_short)|uniprotkb:C1IN(gene name synonym)|uniprotkb:C1NH(gene name synonym)|uniprotkb:C1 esterase inhibitor(gene name synonym)|uniprotkb:C1-inhibiting factor(gene name synonym)|uniprotkb:Serpin G1(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Wang et al. (2017)	pubmed:28742139|imex:IM-29286	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27104478|imex:IM-29286-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001725.1|refseq:NP_958850.1|ensembl:ENSG00000182326(gene)|ensembl:ENST00000328916(transcript)|ensembl:ENST00000360817(transcript)|ensembl:ENST00000406697(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0072562"(blood microparticle)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000859(CUB)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018097|interpro:IPR033116|interpro:IPR035708|interpro:IPR035914|interpro:IPR035976|interpro:IPR043504|rcsb pdb:1ELV|rcsb pdb:1NZI|rcsb pdb:4J1Y|rcsb pdb:4LMF|rcsb pdb:4LOR|rcsb pdb:4LOS|rcsb pdb:4LOT|rcsb pdb:6F1C|rcsb pdb:6F1H|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-977606|refseq:NP_001333779.1|refseq:XP_005253817.1	refseq:NP_000053.2|refseq:NP_001027466.1|dip:DIP-45635N|ensembl:ENSG00000149131(gene)|ensembl:ENST00000278407(transcript)|ensembl:ENST00000676670(transcript)|go:"GO:0001869"(negative regulation of complement activation, lectin pathway)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007568"(aging)|go:"GO:0007596"(blood coagulation)|go:"GO:0008015"(blood circulation)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045087"(innate immune response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR015553(Protease inhibitor I4, serpin C1)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P05155|rcsb pdb:1M6Q|rcsb pdb:2OAY|rcsb pdb:5DU3|rcsb pdb:5DUQ|rcsb pdb:7AKV|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-9657689|reactome:R-HSA-977606	go:"GO:0004252"(serine-type endopeptidase activity)	-	-	figure legend:6A|comment:Addition of Vag8 to a purified system consisting of C1-inh, C1s and C2, results in increased cleavage of C2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/10/11	rogid:3zz5RwIqLyPO71zdCp5Vx7aVl+Y9606	rogid:Y7cqCZ6Ryz51dsi6jM86EXdfeWc9606	rigid:PQUKSkwKtf6FcGQgpPwYu3nLcMA	false	-	-	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0113"(western blot)
uniprotkb:P09871	uniprotkb:Q79GN7	intact:EBI-2810045|uniprotkb:Q9UCU9|uniprotkb:Q9UCV3|uniprotkb:Q9UCU7|uniprotkb:Q9UCV5|uniprotkb:Q9UCV4|uniprotkb:Q9UCU8|uniprotkb:Q9UCV2|uniprotkb:Q9UCV1|uniprotkb:Q9UCV0|uniprotkb:Q9UM14|uniprotkb:D3DUT4|ensembl:ENSP00000328173|ensembl:ENSP00000354057|ensembl:ENSP00000385035	intact:EBI-27104360	psi-mi:c1s_human(display_long)|uniprotkb:C1S(gene name)|psi-mi:C1S(display_short)|uniprotkb:C1 esterase(gene name synonym)|uniprotkb:Complement component 1 subcomponent s(gene name synonym)	psi-mi:q79gn7_borpe(display_long)|uniprotkb:vag8(gene name)|psi-mi:vag8(display_short)|uniprotkb:BP2315(locus name)	psi-mi:"MI:0435"(protease assay)	Wang et al. (2017)	pubmed:28742139|imex:IM-29286	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:257313(borpe)|taxid:257313("Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27104478|imex:IM-29286-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001725.1|refseq:NP_958850.1|ensembl:ENSG00000182326(gene)|ensembl:ENST00000328916(transcript)|ensembl:ENST00000360817(transcript)|ensembl:ENST00000406697(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0072562"(blood microparticle)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000859(CUB)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018097|interpro:IPR033116|interpro:IPR035708|interpro:IPR035914|interpro:IPR035976|interpro:IPR043504|rcsb pdb:1ELV|rcsb pdb:1NZI|rcsb pdb:4J1Y|rcsb pdb:4LMF|rcsb pdb:4LOR|rcsb pdb:4LOS|rcsb pdb:4LOT|rcsb pdb:6F1C|rcsb pdb:6F1H|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-977606|refseq:NP_001333779.1|refseq:XP_005253817.1	go:"GO:0019867"(outer membrane)|refseq:NP_880953.1|refseq:WP_010930866.1|interpro:IPR005546(Autotransporter beta-domain)|interpro:IPR036709|interpro:IPR006315(Outer membrane autotransporter barrel)|interpro:IPR012332(Phage P22 tailspike)|interpro:IPR011050(Pectin lyase fold/virulence factor)|interpro:IPR004899(Pertactin)|interpro:IPR003991(Pertactin virulence factor, C-terminal)	go:"GO:0004252"(serine-type endopeptidase activity)	-	-	figure legend:6A|comment:Addition of Vag8 to a purified system consisting of C1-inh, C1s and C2, results in increased cleavage of C2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/10/11	rogid:3zz5RwIqLyPO71zdCp5Vx7aVl+Y9606	rogid:1PYDfp3AJnkUkhztQL8kyhBPMC0257313	rigid:PQUKSkwKtf6FcGQgpPwYu3nLcMA	false	-	sufficient binding region:16-610(IPR011050)|his tag:n-n	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:P09871	uniprotkb:P06681	intact:EBI-2810045|uniprotkb:Q9UCU9|uniprotkb:Q9UCV3|uniprotkb:Q9UCU7|uniprotkb:Q9UCV5|uniprotkb:Q9UCV4|uniprotkb:Q9UCU8|uniprotkb:Q9UCV2|uniprotkb:Q9UCV1|uniprotkb:Q9UCV0|uniprotkb:Q9UM14|uniprotkb:D3DUT4|ensembl:ENSP00000328173|ensembl:ENSP00000354057|ensembl:ENSP00000385035	intact:EBI-2835920|uniprotkb:Q13904|uniprotkb:O19694|uniprotkb:B4DPF3|uniprotkb:B4DV20|uniprotkb:E9PFN7|ensembl:ENSP00000299367|ensembl:ENSP00000364660|ensembl:ENSP00000372853|ensembl:ENSP00000392835|ensembl:ENSP00000402278|ensembl:ENSP00000405800|ensembl:ENSP00000407961	psi-mi:c1s_human(display_long)|uniprotkb:C1S(gene name)|psi-mi:C1S(display_short)|uniprotkb:C1 esterase(gene name synonym)|uniprotkb:Complement component 1 subcomponent s(gene name synonym)	psi-mi:co2_human(display_long)|uniprotkb:C2(gene name)|psi-mi:C2(display_short)|uniprotkb:C3/C5 convertase(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Wang et al. (2017)	pubmed:28742139|imex:IM-29286	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27104489|imex:IM-29286-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001725.1|refseq:NP_958850.1|ensembl:ENSG00000182326(gene)|ensembl:ENST00000328916(transcript)|ensembl:ENST00000360817(transcript)|ensembl:ENST00000406697(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0072562"(blood microparticle)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000859(CUB)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018097|interpro:IPR033116|interpro:IPR035708|interpro:IPR035914|interpro:IPR035976|interpro:IPR043504|rcsb pdb:1ELV|rcsb pdb:1NZI|rcsb pdb:4J1Y|rcsb pdb:4LMF|rcsb pdb:4LOR|rcsb pdb:4LOS|rcsb pdb:4LOT|rcsb pdb:6F1C|rcsb pdb:6F1H|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-977606|refseq:NP_001333779.1|refseq:XP_005253817.1	refseq:NP_001139375.1|refseq:NP_000054.2|refseq:NP_001171534.1|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR011360(Complement B/C2)|interpro:IPR018114|interpro:IPR033116|interpro:IPR035976|interpro:IPR036465|interpro:IPR037568|interpro:IPR043504|rcsb pdb:2I6Q|rcsb pdb:2I6S|rcsb pdb:2ODP|rcsb pdb:2ODQ|rcsb pdb:3ERB|reactome:R-HSA-166663|reactome:R-HSA-174577|reactome:R-HSA-977606|ensembl:ENSG00000166278(gene)|ensembl:ENSG00000204364(gene)|ensembl:ENSG00000206372(gene)|ensembl:ENSG00000226560(gene)|ensembl:ENSG00000231543(gene)|ensembl:ENSG00000235017(gene)|ensembl:ENSG00000235696(gene)|ensembl:ENST00000299367(transcript)|ensembl:ENST00000375510(transcript)|ensembl:ENST00000383362(transcript)|ensembl:ENST00000411803(transcript)|ensembl:ENST00000413548(transcript)|ensembl:ENST00000416252(transcript)|ensembl:ENST00000448206(transcript)	go:"GO:0004252"(serine-type endopeptidase activity)	-	-	figure legend:6A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/10/11	rogid:3zz5RwIqLyPO71zdCp5Vx7aVl+Y9606	rogid:s5wfD0ZDalMI127hnwt8t8ozbY09606	rigid:h01e+29kI6m6C/u+bQpVx7zrPMg	false	-	-	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:P09871	uniprotkb:P05155	intact:EBI-2810045|uniprotkb:Q9UCU9|uniprotkb:Q9UCV3|uniprotkb:Q9UCU7|uniprotkb:Q9UCV5|uniprotkb:Q9UCV4|uniprotkb:Q9UCU8|uniprotkb:Q9UCV2|uniprotkb:Q9UCV1|uniprotkb:Q9UCV0|uniprotkb:Q9UM14|uniprotkb:D3DUT4|ensembl:ENSP00000328173|ensembl:ENSP00000354057|ensembl:ENSP00000385035	intact:EBI-1223454|uniprotkb:Q547W3|uniprotkb:Q59EI5|uniprotkb:Q96FE0|uniprotkb:A6NMU0|uniprotkb:A8KAI9|uniprotkb:B2R6L5|uniprotkb:Q16304|uniprotkb:Q7Z455|uniprotkb:Q9UC49|uniprotkb:Q9UCF9|uniprotkb:B4E1F0|uniprotkb:B4E1H2|ensembl:ENSP00000278407|ensembl:ENSP00000504807	psi-mi:c1s_human(display_long)|uniprotkb:C1S(gene name)|psi-mi:C1S(display_short)|uniprotkb:C1 esterase(gene name synonym)|uniprotkb:Complement component 1 subcomponent s(gene name synonym)	psi-mi:ic1_human(display_long)|uniprotkb:SERPING1(gene name)|psi-mi:SERPING1(display_short)|uniprotkb:C1IN(gene name synonym)|uniprotkb:C1NH(gene name synonym)|uniprotkb:C1 esterase inhibitor(gene name synonym)|uniprotkb:C1-inhibiting factor(gene name synonym)|uniprotkb:Serpin G1(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Wang et al. (2017)	pubmed:28742139|imex:IM-29286	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27104489|imex:IM-29286-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001725.1|refseq:NP_958850.1|ensembl:ENSG00000182326(gene)|ensembl:ENST00000328916(transcript)|ensembl:ENST00000360817(transcript)|ensembl:ENST00000406697(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0072562"(blood microparticle)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000859(CUB)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018097|interpro:IPR033116|interpro:IPR035708|interpro:IPR035914|interpro:IPR035976|interpro:IPR043504|rcsb pdb:1ELV|rcsb pdb:1NZI|rcsb pdb:4J1Y|rcsb pdb:4LMF|rcsb pdb:4LOR|rcsb pdb:4LOS|rcsb pdb:4LOT|rcsb pdb:6F1C|rcsb pdb:6F1H|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-977606|refseq:NP_001333779.1|refseq:XP_005253817.1	refseq:NP_000053.2|refseq:NP_001027466.1|dip:DIP-45635N|ensembl:ENSG00000149131(gene)|ensembl:ENST00000278407(transcript)|ensembl:ENST00000676670(transcript)|go:"GO:0001869"(negative regulation of complement activation, lectin pathway)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007568"(aging)|go:"GO:0007596"(blood coagulation)|go:"GO:0008015"(blood circulation)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045087"(innate immune response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR015553(Protease inhibitor I4, serpin C1)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P05155|rcsb pdb:1M6Q|rcsb pdb:2OAY|rcsb pdb:5DU3|rcsb pdb:5DUQ|rcsb pdb:7AKV|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-9657689|reactome:R-HSA-977606	go:"GO:0004252"(serine-type endopeptidase activity)	-	-	figure legend:6A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/10/11	rogid:3zz5RwIqLyPO71zdCp5Vx7aVl+Y9606	rogid:Y7cqCZ6Ryz51dsi6jM86EXdfeWc9606	rigid:h01e+29kI6m6C/u+bQpVx7zrPMg	false	-	-	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0113"(western blot)
uniprotkb:P06681	uniprotkb:P09871	intact:EBI-2835920|uniprotkb:Q13904|uniprotkb:O19694|uniprotkb:B4DPF3|uniprotkb:B4DV20|uniprotkb:E9PFN7|ensembl:ENSP00000299367|ensembl:ENSP00000364660|ensembl:ENSP00000372853|ensembl:ENSP00000392835|ensembl:ENSP00000402278|ensembl:ENSP00000405800|ensembl:ENSP00000407961	intact:EBI-2810045|uniprotkb:Q9UCU9|uniprotkb:Q9UCV3|uniprotkb:Q9UCU7|uniprotkb:Q9UCV5|uniprotkb:Q9UCV4|uniprotkb:Q9UCU8|uniprotkb:Q9UCV2|uniprotkb:Q9UCV1|uniprotkb:Q9UCV0|uniprotkb:Q9UM14|uniprotkb:D3DUT4|ensembl:ENSP00000328173|ensembl:ENSP00000354057|ensembl:ENSP00000385035	psi-mi:co2_human(display_long)|uniprotkb:C2(gene name)|psi-mi:C2(display_short)|uniprotkb:C3/C5 convertase(gene name synonym)	psi-mi:c1s_human(display_long)|uniprotkb:C1S(gene name)|psi-mi:C1S(display_short)|uniprotkb:C1 esterase(gene name synonym)|uniprotkb:Complement component 1 subcomponent s(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Wang et al. (2017)	pubmed:28742139|imex:IM-29286	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27104524|imex:IM-29286-17	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139375.1|refseq:NP_000054.2|refseq:NP_001171534.1|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR011360(Complement B/C2)|interpro:IPR018114|interpro:IPR033116|interpro:IPR035976|interpro:IPR036465|interpro:IPR037568|interpro:IPR043504|rcsb pdb:2I6Q|rcsb pdb:2I6S|rcsb pdb:2ODP|rcsb pdb:2ODQ|rcsb pdb:3ERB|reactome:R-HSA-166663|reactome:R-HSA-174577|reactome:R-HSA-977606|ensembl:ENSG00000166278(gene)|ensembl:ENSG00000204364(gene)|ensembl:ENSG00000206372(gene)|ensembl:ENSG00000226560(gene)|ensembl:ENSG00000231543(gene)|ensembl:ENSG00000235017(gene)|ensembl:ENSG00000235696(gene)|ensembl:ENST00000299367(transcript)|ensembl:ENST00000375510(transcript)|ensembl:ENST00000383362(transcript)|ensembl:ENST00000411803(transcript)|ensembl:ENST00000413548(transcript)|ensembl:ENST00000416252(transcript)|ensembl:ENST00000448206(transcript)	refseq:NP_001725.1|refseq:NP_958850.1|ensembl:ENSG00000182326(gene)|ensembl:ENST00000328916(transcript)|ensembl:ENST00000360817(transcript)|ensembl:ENST00000406697(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0072562"(blood microparticle)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000859(CUB)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018097|interpro:IPR033116|interpro:IPR035708|interpro:IPR035914|interpro:IPR035976|interpro:IPR043504|rcsb pdb:1ELV|rcsb pdb:1NZI|rcsb pdb:4J1Y|rcsb pdb:4LMF|rcsb pdb:4LOR|rcsb pdb:4LOS|rcsb pdb:4LOT|rcsb pdb:6F1C|rcsb pdb:6F1H|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-977606|refseq:NP_001333779.1|refseq:XP_005253817.1	go:"GO:0004252"(serine-type endopeptidase activity)	-	-	figure legend:6A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/10/11	rogid:s5wfD0ZDalMI127hnwt8t8ozbY09606	rogid:3zz5RwIqLyPO71zdCp5Vx7aVl+Y9606	rigid:lOrXs+W5S3GItUQ6YSx0NGY3HgE	false	-	-	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)