#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P05161	uniprotkb:P0C6U8-PRO_0000338257	intact:EBI-746466|uniprotkb:Q7Z2G2|uniprotkb:Q96GF0|intact:EBI-1056284|uniprotkb:Q5SVA4|ensembl:ENSP00000496832	intact:EBI-25635190	psi-mi:isg15_human(display_long)|uniprotkb:ISG15(gene name)|psi-mi:ISG15(display_short)|uniprotkb:G1P2(gene name synonym)|uniprotkb:UCRP(gene name synonym)|uniprotkb:Interferon-induced 15 kDa protein(gene name synonym)|uniprotkb:Interferon-induced 17 kDa protein(gene name synonym)|uniprotkb:Ubiquitin cross-reactive protein(gene name synonym)	psi-mi:p0c6u8-pro_0000338257(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:"MI:0435"(protease assay)	Daczkowski et al. (2017)	pubmed:28438633|imex:IM-28308	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25821066|imex:IM-28308-21	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005092.1|ensembl:ENSG00000187608(gene)|ensembl:ENST00000649529(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009615"(response to virus)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031386"(protein tag)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032020"(ISG15-protein conjugation)|go:"GO:0032461"(positive regulation of protein oligomerization)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034340"(response to type I interferon)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0070585"(protein localization to mitochondrion)|interpro:IPR000626(Ubiquitin)|interpro:IPR019956|interpro:IPR029071|mint:P05161|rcsb pdb:1Z2M|rcsb pdb:2HJ8|rcsb pdb:3PHX|rcsb pdb:3PSE|rcsb pdb:3R66|rcsb pdb:3RT3|rcsb pdb:3SDL|rcsb pdb:5TL6|rcsb pdb:5W8T|rcsb pdb:5W8U|rcsb pdb:6BI8|rcsb pdb:6FFA|rcsb pdb:6XA9|reactome:R-HSA-1169408|reactome:R-HSA-168276|reactome:R-HSA-168928|reactome:R-HSA-5656169|reactome:R-HSA-909733|reactome:R-HSA-936440|dip:DIP-29814N	intact:EBI-15810860(chain-parent)	-	-	chain-seq-start:819|chain-seq-end:2740	figure legend:Fig. 2-I|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/09/02	2020/09/02	rogid:k01VuKv72XNTX3hhlIT4Lr0Xl849606	rogid:NKZ5d0D2HjefhmJQwgHz+M1lSt8694009	rigid:/TYItRhFkSsY/tD53UtmHDS5S20	false	his tag:c-c	his tag:c-c|sufficient binding region:723-1037	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:K9N638-PRO_0000422456	uniprotkb:P05161	intact:EBI-25635184	intact:EBI-746466|uniprotkb:Q7Z2G2|uniprotkb:Q96GF0|intact:EBI-1056284|uniprotkb:Q5SVA4|ensembl:ENSP00000496832	psi-mi:k9n638-pro_0000422456(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:isg15_human(display_long)|uniprotkb:ISG15(gene name)|psi-mi:ISG15(display_short)|uniprotkb:G1P2(gene name synonym)|uniprotkb:UCRP(gene name synonym)|uniprotkb:Interferon-induced 15 kDa protein(gene name synonym)|uniprotkb:Interferon-induced 17 kDa protein(gene name synonym)|uniprotkb:Ubiquitin cross-reactive protein(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Daczkowski et al. (2017)	pubmed:28438633|imex:IM-28308	taxid:1263720(cvemc)|taxid:1263720("Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25821105|imex:IM-28308-1	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25618448(chain-parent)	refseq:NP_005092.1|ensembl:ENSG00000187608(gene)|ensembl:ENST00000649529(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009615"(response to virus)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031386"(protein tag)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032020"(ISG15-protein conjugation)|go:"GO:0032461"(positive regulation of protein oligomerization)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034340"(response to type I interferon)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0070585"(protein localization to mitochondrion)|interpro:IPR000626(Ubiquitin)|interpro:IPR019956|interpro:IPR029071|mint:P05161|rcsb pdb:1Z2M|rcsb pdb:2HJ8|rcsb pdb:3PHX|rcsb pdb:3PSE|rcsb pdb:3R66|rcsb pdb:3RT3|rcsb pdb:3SDL|rcsb pdb:5TL6|rcsb pdb:5W8T|rcsb pdb:5W8U|rcsb pdb:6BI8|rcsb pdb:6FFA|rcsb pdb:6XA9|reactome:R-HSA-1169408|reactome:R-HSA-168276|reactome:R-HSA-168928|reactome:R-HSA-5656169|reactome:R-HSA-909733|reactome:R-HSA-936440|dip:DIP-29814N	-	chain-seq-start:854|chain-seq-end:2740	-	figure legend:Fig. 2-I|comment:The accession number provided by the authors AFS88944.1, mapped between 1831-1951 of K9N638, which is equivalent to 978-1099 in PRO_0000422456 chain|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/09/02	2020/09/02	rogid:P9NSm1IurgKbORStjY9C/5q21WM1263720	rogid:k01VuKv72XNTX3hhlIT4Lr0Xl849606	rigid:U0sBfsA4gStoi5DQi9Z8RWEfc1w	false	his tag:n-n|sufficient binding region:978-1099	his tag:c-c	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:R9QB93	uniprotkb:K9N638-PRO_0000422456	intact:EBI-25568326	intact:EBI-25635184	psi-mi:r9qb93_tupbe(display_long)	psi-mi:k9n638-pro_0000422456(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:"MI:0435"(protease assay)	Daczkowski et al. (2017)	pubmed:28438633|imex:IM-28308	taxid:37347(Common tree shrew)|taxid:37347(Tupaia belangeri)	taxid:1263720(cvemc)|taxid:1263720("Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25821183|imex:IM-28308-23	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR019956	intact:EBI-25618448(chain-parent)	-	-	chain-seq-start:854|chain-seq-end:2740	figure legend:Fig. 2-III|comment:The accession number provided by the authors AFS88944.1, mapped between 1831-1951 of K9N638, which is equivalent to 978-1099 in PRO_0000422456 chain|comment:MERS PLpro exhibited weak enzymatic activity|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/09/02	2020/09/02	rogid:EtUQOE+B8D5/kQdqp2eNr/ctlek37347	rogid:P9NSm1IurgKbORStjY9C/5q21WM1263720	rigid:hlqc5AzMVrkQZutH/ZGu+vpyOlQ	false	his tag:c-c	his tag:n-n|sufficient binding region:978-1099	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:R9QB93	uniprotkb:P0C6U8-PRO_0000338257	intact:EBI-25568326	intact:EBI-25635190	psi-mi:r9qb93_tupbe(display_long)	psi-mi:p0c6u8-pro_0000338257(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:"MI:0435"(protease assay)	Daczkowski et al. (2017)	pubmed:28438633|imex:IM-28308	taxid:37347(Common tree shrew)|taxid:37347(Tupaia belangeri)	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25821194|imex:IM-28308-41	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR019956	intact:EBI-15810860(chain-parent)	-	-	chain-seq-start:819|chain-seq-end:2740	figure legend:Fig. 2-III|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/09/02	2020/09/02	rogid:EtUQOE+B8D5/kQdqp2eNr/ctlek37347	rogid:NKZ5d0D2HjefhmJQwgHz+M1lSt8694009	rigid:Y/d/uhXcvZ/VzSwwXOeMmXWlw0g	false	his tag:c-c	sufficient binding region:723-1037|his tag:c-c	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:P0C6V0-PRO_0000338281	uniprotkb:R9QB93	intact:EBI-25821269	intact:EBI-25568326	psi-mi:p0c6v0-pro_0000338281(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:r9qb93_tupbe(display_long)	psi-mi:"MI:0435"(protease assay)	Daczkowski et al. (2017)	pubmed:28438633|imex:IM-28308	taxid:11142(cvma5)|taxid:11142("Murine coronavirus (strain A59)")	taxid:37347(Common tree shrew)|taxid:37347(Tupaia belangeri)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25821276|imex:IM-28308-43	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25821214(chain-parent)	interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR019956	-	chain-seq-start:833|chain-seq-end:2837	-	figure legend:Fig. 2-III|comment:MHV PLpro demonstrated moderate enzyme activity for the northern tree shrew ISG15 protein|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/09/02	2020/09/02	rogid:/X+hmk/7yCyCykKykcDQ4x7OBSs11142	rogid:EtUQOE+B8D5/kQdqp2eNr/ctlek37347	rigid:ySI8vO35LUr0tj47LvGsMymDrsQ	false	-	his tag:c-c	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:K9N638-PRO_0000422456	uniprotkb:E0D5D4	intact:EBI-25635184	intact:EBI-25821312	psi-mi:k9n638-pro_0000422456(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:e0d5d4_oplfa(display_long)|uniprotkb:ISG15(gene name)|psi-mi:ISG15(display_short)	psi-mi:"MI:0435"(protease assay)	Daczkowski et al. (2017)	pubmed:28438633|imex:IM-28308	taxid:1263720(cvemc)|taxid:1263720("Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1)")	taxid:163134(Barred knifejaw)|taxid:163134(Oplegnathus fasciatus)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25821283|imex:IM-28308-3	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25618448(chain-parent)	interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR019956	-	chain-seq-start:854|chain-seq-end:2740	-	figure legend:Fig. 2-IV|comment:The accession number provided by the authors AFS88944.1, mapped between 1831-1951 of K9N638, which is equivalent to 978-1099 in PRO_0000422456 chain|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/09/02	2020/09/02	rogid:P9NSm1IurgKbORStjY9C/5q21WM1263720	rogid:Ir7xoBjjAN7D+0zQeKKWAphUHCI163134	rigid:8Sk3Ec5ky651dLUA5lVMBKMMjLE	false	his tag:n-n|sufficient binding region:978-1099	his tag:c-c	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:P0C6V0-PRO_0000338281	uniprotkb:E0D5D4	intact:EBI-25821269	intact:EBI-25821312	psi-mi:p0c6v0-pro_0000338281(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:e0d5d4_oplfa(display_long)|uniprotkb:ISG15(gene name)|psi-mi:ISG15(display_short)	psi-mi:"MI:0435"(protease assay)	Daczkowski et al. (2017)	pubmed:28438633|imex:IM-28308	taxid:11142(cvma5)|taxid:11142("Murine coronavirus (strain A59)")	taxid:163134(Barred knifejaw)|taxid:163134(Oplegnathus fasciatus)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25821334|imex:IM-28308-5	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25821214(chain-parent)	interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR019956	-	chain-seq-start:833|chain-seq-end:2837	-	figure legend:Fig. 2-IV|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/09/02	2020/09/02	rogid:/X+hmk/7yCyCykKykcDQ4x7OBSs11142	rogid:Ir7xoBjjAN7D+0zQeKKWAphUHCI163134	rigid:hH1ByE6740TZRIO817Ir/xTDvu8	false	-	his tag:c-c	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:Q64339	uniprotkb:K9N638-PRO_0000422456	intact:EBI-8345781|uniprotkb:Q8K0H3|intact:MINT-4139466|ensembl:ENSMUSP00000082548	intact:EBI-25635184	psi-mi:isg15_mouse(display_long)|uniprotkb:Isg15(gene name)|psi-mi:Isg15(display_short)|uniprotkb:G1p2(gene name synonym)|uniprotkb:Ucrp(gene name synonym)|uniprotkb:Interferon-induced 15 kDa protein(gene name synonym)|uniprotkb:Interferon-induced 17 kDa protein(gene name synonym)|uniprotkb:Ubiquitin cross-reactive protein(gene name synonym)	psi-mi:k9n638-pro_0000422456(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:"MI:0435"(protease assay)	Daczkowski et al. (2017)	pubmed:28438633|imex:IM-28308	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:1263720(cvemc)|taxid:1263720("Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25821343|imex:IM-28308-45	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056598.2|ensembl:ENSMUSG00000035692(gene)|ensembl:ENSMUST00000085425(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031386"(protein tag)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032020"(ISG15-protein conjugation)|go:"GO:0032461"(positive regulation of protein oligomerization)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034340"(response to type I interferon)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0070585"(protein localization to mitochondrion)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|mint:Q64339|rcsb pdb:5CHF|rcsb pdb:5CHV|rcsb pdb:5CHW|rcsb pdb:5JZE|rcsb pdb:5TL7|rcsb pdb:5TLA|rcsb pdb:6J62|rcsb pdb:6YVA|reactome:R-MMU-1169408|reactome:R-MMU-5656169	intact:EBI-25618448(chain-parent)	-	function:"In response to IFN-tau secreted by the conceptus, may ligate to and regulate proteins involved in the release of prostaglandin F2-alpha (PGF), and thus prevent lysis of the corpus luteum and maintain the pregnancy"|comment:mint|function:Ubiquitin-like protein that is conjugated to intracellular target proteins after IFN-alpha or IFN-beta stimulation. Its enzymatic pathway is partially distinct from that of ubiquitin, differing in substrate specificity and interaction with ligating enzymes. ISG15 conjugation pathway uses a dedicated E1 enzyme, but seems to converge with the Ub conjugation pathway at the level of a specific E2 enzyme. Targets include STAT1, SERPINA3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, EIF2AK2/PKR, MX1/MxA, and RIG-1. Deconjugated by USP18/UBP43. Shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. May serve as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments. May also be involved in autocrine, paracrine and endocrine mechanisms, as in cell-to-cell signaling, possibly partly by inducing IFN-gamma secretion by monocytes and macrophages. Seems to display antiviral activity during viral infections	chain-seq-start:854|chain-seq-end:2740	figure legend:Fig. 2-V|comment:The accession number provided by the authors AFS88944.1, mapped between 1831-1951 of K9N638, which is equivalent to 978-1099 in PRO_0000422456 chain|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/09/02	2020/09/02	rogid:rLwDq3/OLBVXU0U9MVyiTeULqog10090	rogid:P9NSm1IurgKbORStjY9C/5q21WM1263720	rigid:blw7Gsv70To3BD3dnC2ctK8czgc	false	his tag:c-c|mutation:76-76	his tag:n-n|sufficient binding region:978-1099	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:Q64339	uniprotkb:P0C6U8-PRO_0000338257	intact:EBI-8345781|uniprotkb:Q8K0H3|intact:MINT-4139466|ensembl:ENSMUSP00000082548	intact:EBI-25635190	psi-mi:isg15_mouse(display_long)|uniprotkb:Isg15(gene name)|psi-mi:Isg15(display_short)|uniprotkb:G1p2(gene name synonym)|uniprotkb:Ucrp(gene name synonym)|uniprotkb:Interferon-induced 15 kDa protein(gene name synonym)|uniprotkb:Interferon-induced 17 kDa protein(gene name synonym)|uniprotkb:Ubiquitin cross-reactive protein(gene name synonym)	psi-mi:p0c6u8-pro_0000338257(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:"MI:0435"(protease assay)	Daczkowski et al. (2017)	pubmed:28438633|imex:IM-28308	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25821352|imex:IM-28308-7	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056598.2|ensembl:ENSMUSG00000035692(gene)|ensembl:ENSMUST00000085425(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031386"(protein tag)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032020"(ISG15-protein conjugation)|go:"GO:0032461"(positive regulation of protein oligomerization)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034340"(response to type I interferon)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0070585"(protein localization to mitochondrion)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|mint:Q64339|rcsb pdb:5CHF|rcsb pdb:5CHV|rcsb pdb:5CHW|rcsb pdb:5JZE|rcsb pdb:5TL7|rcsb pdb:5TLA|rcsb pdb:6J62|rcsb pdb:6YVA|reactome:R-MMU-1169408|reactome:R-MMU-5656169	intact:EBI-15810860(chain-parent)	-	function:"In response to IFN-tau secreted by the conceptus, may ligate to and regulate proteins involved in the release of prostaglandin F2-alpha (PGF), and thus prevent lysis of the corpus luteum and maintain the pregnancy"|comment:mint|function:Ubiquitin-like protein that is conjugated to intracellular target proteins after IFN-alpha or IFN-beta stimulation. Its enzymatic pathway is partially distinct from that of ubiquitin, differing in substrate specificity and interaction with ligating enzymes. ISG15 conjugation pathway uses a dedicated E1 enzyme, but seems to converge with the Ub conjugation pathway at the level of a specific E2 enzyme. Targets include STAT1, SERPINA3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, EIF2AK2/PKR, MX1/MxA, and RIG-1. Deconjugated by USP18/UBP43. Shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. May serve as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments. May also be involved in autocrine, paracrine and endocrine mechanisms, as in cell-to-cell signaling, possibly partly by inducing IFN-gamma secretion by monocytes and macrophages. Seems to display antiviral activity during viral infections	chain-seq-start:819|chain-seq-end:2740	figure legend:Fig. 2-V|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/09/02	2020/09/02	rogid:rLwDq3/OLBVXU0U9MVyiTeULqog10090	rogid:NKZ5d0D2HjefhmJQwgHz+M1lSt8694009	rigid:Qs+CKVQJRvmpeRhw7gjB45bl3Tg	false	mutation:76-76|his tag:c-c	his tag:c-c|sufficient binding region:723-1037	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:Q64339	uniprotkb:P0C6V0-PRO_0000338281	intact:EBI-8345781|uniprotkb:Q8K0H3|intact:MINT-4139466|ensembl:ENSMUSP00000082548	intact:EBI-25821269	psi-mi:isg15_mouse(display_long)|uniprotkb:Isg15(gene name)|psi-mi:Isg15(display_short)|uniprotkb:G1p2(gene name synonym)|uniprotkb:Ucrp(gene name synonym)|uniprotkb:Interferon-induced 15 kDa protein(gene name synonym)|uniprotkb:Interferon-induced 17 kDa protein(gene name synonym)|uniprotkb:Ubiquitin cross-reactive protein(gene name synonym)	psi-mi:p0c6v0-pro_0000338281(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:"MI:0435"(protease assay)	Daczkowski et al. (2017)	pubmed:28438633|imex:IM-28308	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:11142(cvma5)|taxid:11142("Murine coronavirus (strain A59)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25821362|imex:IM-28308-25	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056598.2|ensembl:ENSMUSG00000035692(gene)|ensembl:ENSMUST00000085425(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031386"(protein tag)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032020"(ISG15-protein conjugation)|go:"GO:0032461"(positive regulation of protein oligomerization)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034340"(response to type I interferon)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0070585"(protein localization to mitochondrion)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|mint:Q64339|rcsb pdb:5CHF|rcsb pdb:5CHV|rcsb pdb:5CHW|rcsb pdb:5JZE|rcsb pdb:5TL7|rcsb pdb:5TLA|rcsb pdb:6J62|rcsb pdb:6YVA|reactome:R-MMU-1169408|reactome:R-MMU-5656169	intact:EBI-25821214(chain-parent)	-	function:"In response to IFN-tau secreted by the conceptus, may ligate to and regulate proteins involved in the release of prostaglandin F2-alpha (PGF), and thus prevent lysis of the corpus luteum and maintain the pregnancy"|comment:mint|function:Ubiquitin-like protein that is conjugated to intracellular target proteins after IFN-alpha or IFN-beta stimulation. Its enzymatic pathway is partially distinct from that of ubiquitin, differing in substrate specificity and interaction with ligating enzymes. ISG15 conjugation pathway uses a dedicated E1 enzyme, but seems to converge with the Ub conjugation pathway at the level of a specific E2 enzyme. Targets include STAT1, SERPINA3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, EIF2AK2/PKR, MX1/MxA, and RIG-1. Deconjugated by USP18/UBP43. Shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. May serve as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments. May also be involved in autocrine, paracrine and endocrine mechanisms, as in cell-to-cell signaling, possibly partly by inducing IFN-gamma secretion by monocytes and macrophages. Seems to display antiviral activity during viral infections	chain-seq-start:833|chain-seq-end:2837	figure legend:Fig. 2-V|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/09/02	2020/09/02	rogid:rLwDq3/OLBVXU0U9MVyiTeULqog10090	rogid:/X+hmk/7yCyCykKykcDQ4x7OBSs11142	rigid:AJLcOVQGMd76Rd711r5gcsDTQnM	false	mutation:76-76|his tag:c-c	-	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:A0A5N4DAX7	uniprotkb:K9N638-PRO_0000422456	intact:EBI-25821387	intact:EBI-25635184	psi-mi:a0a5n4dax7_camdr(display_long)|uniprotkb:Cadr_000013024(orf name)	psi-mi:k9n638-pro_0000422456(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:"MI:0435"(protease assay)	Daczkowski et al. (2017)	pubmed:28438633|imex:IM-28308	taxid:9838(camdr)|taxid:9838(Camelus dromedarius)	taxid:1263720(cvemc)|taxid:1263720("Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25821368|imex:IM-28308-9	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR019956	intact:EBI-25618448(chain-parent)	-	-	chain-seq-start:854|chain-seq-end:2740	figure legend:Fig. 2-VI|comment:The accession number provided by the authors AFS88944.1, mapped between 1831-1951 of K9N638, which is equivalent to 978-1099 in PRO_0000422456 chain|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/09/02	2020/09/02	rogid:24f6q1f4RIYXMOoR/0vzbssOCWE9838	rogid:P9NSm1IurgKbORStjY9C/5q21WM1263720	rigid:q6nr66ibptpem+BueB4uRZC5kzY	false	his tag:c-c	his tag:n-n|sufficient binding region:978-1099	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:P0C6U8-PRO_0000338257	uniprotkb:A0A5N4DAX7	intact:EBI-25635190	intact:EBI-25821387	psi-mi:p0c6u8-pro_0000338257(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:a0a5n4dax7_camdr(display_long)|uniprotkb:Cadr_000013024(orf name)	psi-mi:"MI:0435"(protease assay)	Daczkowski et al. (2017)	pubmed:28438633|imex:IM-28308	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	taxid:9838(camdr)|taxid:9838(Camelus dromedarius)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25821415|imex:IM-28308-11	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-15810860(chain-parent)	interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR019956	-	chain-seq-start:819|chain-seq-end:2740	-	figure legend:Fig. 2-VI|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/09/02	2020/09/02	rogid:NKZ5d0D2HjefhmJQwgHz+M1lSt8694009	rogid:24f6q1f4RIYXMOoR/0vzbssOCWE9838	rigid:NgAeb2UyGy95EJQBMIUADo6VpH4	false	his tag:c-c|sufficient binding region:723-1037	his tag:c-c	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:Q9GKP4	uniprotkb:P0C6U8-PRO_0000338257	intact:EBI-25821151	intact:EBI-25635190	psi-mi:q9gkp4_sheep(display_long)|uniprotkb:ISG17(gene name)|psi-mi:ISG17(display_short)	psi-mi:p0c6u8-pro_0000338257(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:"MI:0435"(protease assay)	Daczkowski et al. (2017)	pubmed:28438633|imex:IM-28308	taxid:9940(sheep)|taxid:9940("Ovis aries (Sheep)")	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25821587|imex:IM-28308-27	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001009735.1|rcsb pdb:6OAR|rcsb pdb:6OAT|interpro:IPR000626(Ubiquitin)|interpro:IPR029071	intact:EBI-15810860(chain-parent)	-	-	chain-seq-start:819|chain-seq-end:2740	figure legend:Fig. 2-II|caution:The given accession number for Sheep ISG15 AF152103.1, actually corresponds to ISG17|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/09/02	2020/09/03	rogid:gyvyyeTX8t3mhHFK8aPQD9a7fFI9940	rogid:NKZ5d0D2HjefhmJQwgHz+M1lSt8694009	rigid:TkfewERuWXCQZhMTBOKRU9Ie4cQ	false	his tag:c-c	sufficient binding region:723-1037|his tag:c-c	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:Q9GKP4	uniprotkb:K9N638-PRO_0000422456	intact:EBI-25821151	intact:EBI-25635184	psi-mi:q9gkp4_sheep(display_long)|uniprotkb:ISG17(gene name)|psi-mi:ISG17(display_short)	psi-mi:k9n638-pro_0000422456(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:"MI:0435"(protease assay)	Daczkowski et al. (2017)	pubmed:28438633|imex:IM-28308	taxid:9940(sheep)|taxid:9940("Ovis aries (Sheep)")	taxid:1263720(cvemc)|taxid:1263720("Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25821596|imex:IM-28308-29	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001009735.1|rcsb pdb:6OAR|rcsb pdb:6OAT|interpro:IPR000626(Ubiquitin)|interpro:IPR029071	intact:EBI-25618448(chain-parent)	-	-	chain-seq-start:854|chain-seq-end:2740	figure legend:Fig. 2-II|comment:The accession number provided by the authors AFS88944.1, mapped between 1831-1951 of K9N638, which is equivalent to 978-1099 in PRO_0000422456 chain|caution:The given accession number for Sheep ISG15 AF152103.1, actually corresponds to ISG17|comment:MERS PLpro exhibited weak enzymatic activity|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/09/02	2020/09/03	rogid:gyvyyeTX8t3mhHFK8aPQD9a7fFI9940	rogid:P9NSm1IurgKbORStjY9C/5q21WM1263720	rigid:IkWxKt2YlU0U2B+NADkiN0Yusjo	false	his tag:c-c	his tag:n-n|sufficient binding region:978-1099	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:L5LC70	uniprotkb:K9N638-PRO_0000422456	intact:EBI-25760965	intact:EBI-25635184	psi-mi:l5lc70_myods(display_long)|uniprotkb:MDA_GLEAN10007532(orf name)	psi-mi:k9n638-pro_0000422456(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:"MI:0435"(protease assay)	Daczkowski et al. (2017)	pubmed:28438633|imex:IM-28308	taxid:225400(David's myotis)|taxid:225400(Myotis davidii)	taxid:1263720(cvemc)|taxid:1263720("Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25821608|imex:IM-28308-31	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6MDH|interpro:IPR000626(Ubiquitin)|interpro:IPR029071	intact:EBI-25618448(chain-parent)	-	-	chain-seq-start:854|chain-seq-end:2740	figure legend:Fig. 2-VII|comment:The accession number provided by the authors AFS88944.1, mapped between 1831-1951 of K9N638, which is equivalent to 978-1099 in PRO_0000422456 chain|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/09/02	2020/09/03	rogid:lRy7vrf4hv09cNqGxRAtdpwts/Q225400	rogid:P9NSm1IurgKbORStjY9C/5q21WM1263720	rigid:HaGz/Gh85w4XT5iCABmakO3ektU	false	his tag:c-c	his tag:n-n|sufficient binding region:978-1099	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:L5LC70	uniprotkb:P0C6U8-PRO_0000338257	intact:EBI-25760965	intact:EBI-25635190	psi-mi:l5lc70_myods(display_long)|uniprotkb:MDA_GLEAN10007532(orf name)	psi-mi:p0c6u8-pro_0000338257(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:"MI:0435"(protease assay)	Daczkowski et al. (2017)	pubmed:28438633|imex:IM-28308	taxid:225400(David's myotis)|taxid:225400(Myotis davidii)	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25821619|imex:IM-28308-13	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6MDH|interpro:IPR000626(Ubiquitin)|interpro:IPR029071	intact:EBI-15810860(chain-parent)	-	-	chain-seq-start:819|chain-seq-end:2740	figure legend:Fig. 2-VII|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/09/02	2020/09/03	rogid:lRy7vrf4hv09cNqGxRAtdpwts/Q225400	rogid:NKZ5d0D2HjefhmJQwgHz+M1lSt8694009	rigid:GqXiIbQPQJAjjisYVaDEuGBMilo	false	his tag:c-c	sufficient binding region:723-1037|his tag:c-c	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:P05161-PRO_0000035986	uniprotkb:P0C6U8-PRO_0000338257	intact:EBI-25821651	intact:EBI-25635190	psi-mi:p05161-pro_0000035986(display_long)|uniprotkb:ISG15(gene name)|psi-mi:ISG15(display_short)|uniprotkb:G1P2(gene name synonym)|uniprotkb:UCRP(gene name synonym)|uniprotkb:Interferon-induced 15 kDa protein(gene name synonym)|uniprotkb:Interferon-induced 17 kDa protein(gene name synonym)|uniprotkb:Ubiquitin cross-reactive protein(gene name synonym)	psi-mi:p0c6u8-pro_0000338257(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Daczkowski et al. (2017)	pubmed:28438633|imex:IM-28308	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25821658|imex:IM-28308-33	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-746466(chain-parent)	intact:EBI-15810860(chain-parent)	-	chain-seq-start:2|chain-seq-end:157	chain-seq-start:819|chain-seq-end:2740	figure legend:"Fig. 3 (top panel), Table 2"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:57.6x10^-6 ~3.21(molar)	2020/09/02	2020/09/03	rogid:OHulVcaywr/I9bIR8RFMRL7el1I9606	rogid:NKZ5d0D2HjefhmJQwgHz+M1lSt8694009	rigid:E6JeH3hSM26dgglBCKHpTgX/shc	false	-	his tag:c-c|sufficient binding region:723-1037	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:K9N638-PRO_0000422456	uniprotkb:P05161-PRO_0000035986	intact:EBI-25635184	intact:EBI-25821651	psi-mi:k9n638-pro_0000422456(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:p05161-pro_0000035986(display_long)|uniprotkb:ISG15(gene name)|psi-mi:ISG15(display_short)|uniprotkb:G1P2(gene name synonym)|uniprotkb:UCRP(gene name synonym)|uniprotkb:Interferon-induced 15 kDa protein(gene name synonym)|uniprotkb:Interferon-induced 17 kDa protein(gene name synonym)|uniprotkb:Ubiquitin cross-reactive protein(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Daczkowski et al. (2017)	pubmed:28438633|imex:IM-28308	taxid:1263720(cvemc)|taxid:1263720("Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25821663|imex:IM-28308-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25618448(chain-parent)	intact:EBI-746466(chain-parent)	-	chain-seq-start:854|chain-seq-end:2740	chain-seq-start:2|chain-seq-end:157	figure legend:"Fig. 3 (bottom panel), Table 2"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:59.3x10^-6 ~4.5(molar)	2020/09/02	2020/09/03	rogid:P9NSm1IurgKbORStjY9C/5q21WM1263720	rogid:OHulVcaywr/I9bIR8RFMRL7el1I9606	rigid:IlscQ6Mf3WQ60FGCQf7WBOqtQMc	false	sufficient binding region:978-1099|his tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9GKP4	uniprotkb:P0C6U8-PRO_0000338257	intact:EBI-25821151	intact:EBI-25635190	psi-mi:q9gkp4_sheep(display_long)|uniprotkb:ISG17(gene name)|psi-mi:ISG17(display_short)	psi-mi:p0c6u8-pro_0000338257(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Daczkowski et al. (2017)	pubmed:28438633|imex:IM-28308	taxid:9940(sheep)|taxid:9940("Ovis aries (Sheep)")	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25821709|imex:IM-28308-47	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001009735.1|rcsb pdb:6OAR|rcsb pdb:6OAT|interpro:IPR000626(Ubiquitin)|interpro:IPR029071	intact:EBI-15810860(chain-parent)	-	-	chain-seq-start:819|chain-seq-end:2740	figure legend:"Fig. 3 (top panel), Table 2"|caution:The given accession number for Sheep ISG15 AF152103.1, actually corresponds to ISG17|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:200.0x10^-6 ~41.0(molar)	2020/09/02	2020/09/03	rogid:gyvyyeTX8t3mhHFK8aPQD9a7fFI9940	rogid:NKZ5d0D2HjefhmJQwgHz+M1lSt8694009	rigid:TkfewERuWXCQZhMTBOKRU9Ie4cQ	false	his tag:c-c	sufficient binding region:723-1037|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05161	uniprotkb:P0C6U8-PRO_0000338257	intact:EBI-746466|uniprotkb:Q7Z2G2|uniprotkb:Q96GF0|intact:EBI-1056284|uniprotkb:Q5SVA4|ensembl:ENSP00000496832	intact:EBI-25635190	psi-mi:isg15_human(display_long)|uniprotkb:ISG15(gene name)|psi-mi:ISG15(display_short)|uniprotkb:G1P2(gene name synonym)|uniprotkb:UCRP(gene name synonym)|uniprotkb:Interferon-induced 15 kDa protein(gene name synonym)|uniprotkb:Interferon-induced 17 kDa protein(gene name synonym)|uniprotkb:Ubiquitin cross-reactive protein(gene name synonym)	psi-mi:p0c6u8-pro_0000338257(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Daczkowski et al. (2017)	pubmed:28438633|imex:IM-28308	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25821760|imex:IM-28308-35	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005092.1|ensembl:ENSG00000187608(gene)|ensembl:ENST00000649529(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009615"(response to virus)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031386"(protein tag)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032020"(ISG15-protein conjugation)|go:"GO:0032461"(positive regulation of protein oligomerization)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034340"(response to type I interferon)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0070585"(protein localization to mitochondrion)|interpro:IPR000626(Ubiquitin)|interpro:IPR019956|interpro:IPR029071|mint:P05161|rcsb pdb:1Z2M|rcsb pdb:2HJ8|rcsb pdb:3PHX|rcsb pdb:3PSE|rcsb pdb:3R66|rcsb pdb:3RT3|rcsb pdb:3SDL|rcsb pdb:5TL6|rcsb pdb:5W8T|rcsb pdb:5W8U|rcsb pdb:6BI8|rcsb pdb:6FFA|rcsb pdb:6XA9|reactome:R-HSA-1169408|reactome:R-HSA-168276|reactome:R-HSA-168928|reactome:R-HSA-5656169|reactome:R-HSA-909733|reactome:R-HSA-936440|dip:DIP-29814N	intact:EBI-15810860(chain-parent)	-	-	chain-seq-start:819|chain-seq-end:2740	figure legend:"Fig. 3 (top panel), Table 2"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:20.5x10^-6 ~4.48(molar)	2020/09/02	2020/09/03	rogid:k01VuKv72XNTX3hhlIT4Lr0Xl849606	rogid:NKZ5d0D2HjefhmJQwgHz+M1lSt8694009	rigid:/TYItRhFkSsY/tD53UtmHDS5S20	false	his tag:c-c	his tag:c-c|sufficient binding region:723-1037	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9GKP4	uniprotkb:K9N638-PRO_0000422456	intact:EBI-25821151	intact:EBI-25635184	psi-mi:q9gkp4_sheep(display_long)|uniprotkb:ISG17(gene name)|psi-mi:ISG17(display_short)	psi-mi:k9n638-pro_0000422456(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Daczkowski et al. (2017)	pubmed:28438633|imex:IM-28308	taxid:9940(sheep)|taxid:9940("Ovis aries (Sheep)")	taxid:1263720(cvemc)|taxid:1263720("Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25823097|imex:IM-28308-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001009735.1|rcsb pdb:6OAR|rcsb pdb:6OAT|interpro:IPR000626(Ubiquitin)|interpro:IPR029071	intact:EBI-25618448(chain-parent)	-	-	chain-seq-start:854|chain-seq-end:2740	figure legend:"Fig. 3 (bottom panel), Table 2"|caution:The given accession number for Sheep ISG15 AF152103.1, actually corresponds to ISG17|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:172.0x10^-6 ~38.5(molar)	2020/09/02	2020/09/03	rogid:gyvyyeTX8t3mhHFK8aPQD9a7fFI9940	rogid:P9NSm1IurgKbORStjY9C/5q21WM1263720	rigid:IkWxKt2YlU0U2B+NADkiN0Yusjo	false	his tag:c-c	sufficient binding region:978-1099|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q64339	uniprotkb:P0C6U8-PRO_0000338257	intact:EBI-8345781|uniprotkb:Q8K0H3|intact:MINT-4139466|ensembl:ENSMUSP00000082548	intact:EBI-25635190	psi-mi:isg15_mouse(display_long)|uniprotkb:Isg15(gene name)|psi-mi:Isg15(display_short)|uniprotkb:G1p2(gene name synonym)|uniprotkb:Ucrp(gene name synonym)|uniprotkb:Interferon-induced 15 kDa protein(gene name synonym)|uniprotkb:Interferon-induced 17 kDa protein(gene name synonym)|uniprotkb:Ubiquitin cross-reactive protein(gene name synonym)	psi-mi:p0c6u8-pro_0000338257(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Daczkowski et al. (2017)	pubmed:28438633|imex:IM-28308	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25823111|imex:IM-28308-49	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056598.2|ensembl:ENSMUSG00000035692(gene)|ensembl:ENSMUST00000085425(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031386"(protein tag)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032020"(ISG15-protein conjugation)|go:"GO:0032461"(positive regulation of protein oligomerization)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034340"(response to type I interferon)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0070585"(protein localization to mitochondrion)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|mint:Q64339|rcsb pdb:5CHF|rcsb pdb:5CHV|rcsb pdb:5CHW|rcsb pdb:5JZE|rcsb pdb:5TL7|rcsb pdb:5TLA|rcsb pdb:6J62|rcsb pdb:6YVA|reactome:R-MMU-1169408|reactome:R-MMU-5656169	intact:EBI-15810860(chain-parent)	-	function:"In response to IFN-tau secreted by the conceptus, may ligate to and regulate proteins involved in the release of prostaglandin F2-alpha (PGF), and thus prevent lysis of the corpus luteum and maintain the pregnancy"|comment:mint|function:Ubiquitin-like protein that is conjugated to intracellular target proteins after IFN-alpha or IFN-beta stimulation. Its enzymatic pathway is partially distinct from that of ubiquitin, differing in substrate specificity and interaction with ligating enzymes. ISG15 conjugation pathway uses a dedicated E1 enzyme, but seems to converge with the Ub conjugation pathway at the level of a specific E2 enzyme. Targets include STAT1, SERPINA3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, EIF2AK2/PKR, MX1/MxA, and RIG-1. Deconjugated by USP18/UBP43. Shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. May serve as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments. May also be involved in autocrine, paracrine and endocrine mechanisms, as in cell-to-cell signaling, possibly partly by inducing IFN-gamma secretion by monocytes and macrophages. Seems to display antiviral activity during viral infections	chain-seq-start:819|chain-seq-end:2740	figure legend:"Fig. 3 (top panel), Table 2"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:196.0x10^-6 ~68.0(molar)	2020/09/02	2020/09/03	rogid:rLwDq3/OLBVXU0U9MVyiTeULqog10090	rogid:NKZ5d0D2HjefhmJQwgHz+M1lSt8694009	rigid:Qs+CKVQJRvmpeRhw7gjB45bl3Tg	false	his tag:c-c	his tag:c-c|sufficient binding region:723-1037	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q64339	uniprotkb:K9N638-PRO_0000422456	intact:EBI-8345781|uniprotkb:Q8K0H3|intact:MINT-4139466|ensembl:ENSMUSP00000082548	intact:EBI-25635184	psi-mi:isg15_mouse(display_long)|uniprotkb:Isg15(gene name)|psi-mi:Isg15(display_short)|uniprotkb:G1p2(gene name synonym)|uniprotkb:Ucrp(gene name synonym)|uniprotkb:Interferon-induced 15 kDa protein(gene name synonym)|uniprotkb:Interferon-induced 17 kDa protein(gene name synonym)|uniprotkb:Ubiquitin cross-reactive protein(gene name synonym)	psi-mi:k9n638-pro_0000422456(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Daczkowski et al. (2017)	pubmed:28438633|imex:IM-28308	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:1263720(cvemc)|taxid:1263720("Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25823120|imex:IM-28308-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056598.2|ensembl:ENSMUSG00000035692(gene)|ensembl:ENSMUST00000085425(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031386"(protein tag)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032020"(ISG15-protein conjugation)|go:"GO:0032461"(positive regulation of protein oligomerization)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034340"(response to type I interferon)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0070585"(protein localization to mitochondrion)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|mint:Q64339|rcsb pdb:5CHF|rcsb pdb:5CHV|rcsb pdb:5CHW|rcsb pdb:5JZE|rcsb pdb:5TL7|rcsb pdb:5TLA|rcsb pdb:6J62|rcsb pdb:6YVA|reactome:R-MMU-1169408|reactome:R-MMU-5656169	intact:EBI-25618448(chain-parent)	-	function:"In response to IFN-tau secreted by the conceptus, may ligate to and regulate proteins involved in the release of prostaglandin F2-alpha (PGF), and thus prevent lysis of the corpus luteum and maintain the pregnancy"|comment:mint|function:Ubiquitin-like protein that is conjugated to intracellular target proteins after IFN-alpha or IFN-beta stimulation. Its enzymatic pathway is partially distinct from that of ubiquitin, differing in substrate specificity and interaction with ligating enzymes. ISG15 conjugation pathway uses a dedicated E1 enzyme, but seems to converge with the Ub conjugation pathway at the level of a specific E2 enzyme. Targets include STAT1, SERPINA3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, EIF2AK2/PKR, MX1/MxA, and RIG-1. Deconjugated by USP18/UBP43. Shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. May serve as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments. May also be involved in autocrine, paracrine and endocrine mechanisms, as in cell-to-cell signaling, possibly partly by inducing IFN-gamma secretion by monocytes and macrophages. Seems to display antiviral activity during viral infections	chain-seq-start:854|chain-seq-end:2740	figure legend:"Fig. 3 (bottom panel), Table 2"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:376.0x10^-6 ~52.8(molar)	2020/09/02	2020/09/03	rogid:rLwDq3/OLBVXU0U9MVyiTeULqog10090	rogid:P9NSm1IurgKbORStjY9C/5q21WM1263720	rigid:blw7Gsv70To3BD3dnC2ctK8czgc	false	his tag:c-c	sufficient binding region:978-1099|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05161	uniprotkb:P0C6U8-PRO_0000338257	intact:EBI-746466|uniprotkb:Q7Z2G2|uniprotkb:Q96GF0|intact:EBI-1056284|uniprotkb:Q5SVA4|ensembl:ENSP00000496832	intact:EBI-25635190	psi-mi:isg15_human(display_long)|uniprotkb:ISG15(gene name)|psi-mi:ISG15(display_short)|uniprotkb:G1P2(gene name synonym)|uniprotkb:UCRP(gene name synonym)|uniprotkb:Interferon-induced 15 kDa protein(gene name synonym)|uniprotkb:Interferon-induced 17 kDa protein(gene name synonym)|uniprotkb:Ubiquitin cross-reactive protein(gene name synonym)	psi-mi:p0c6u8-pro_0000338257(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:"MI:0435"(protease assay)	Daczkowski et al. (2017)	pubmed:28438633|imex:IM-28308	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25823163|imex:IM-28308-37	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005092.1|ensembl:ENSG00000187608(gene)|ensembl:ENST00000649529(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009615"(response to virus)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031386"(protein tag)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032020"(ISG15-protein conjugation)|go:"GO:0032461"(positive regulation of protein oligomerization)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034340"(response to type I interferon)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0070585"(protein localization to mitochondrion)|interpro:IPR000626(Ubiquitin)|interpro:IPR019956|interpro:IPR029071|mint:P05161|rcsb pdb:1Z2M|rcsb pdb:2HJ8|rcsb pdb:3PHX|rcsb pdb:3PSE|rcsb pdb:3R66|rcsb pdb:3RT3|rcsb pdb:3SDL|rcsb pdb:5TL6|rcsb pdb:5W8T|rcsb pdb:5W8U|rcsb pdb:6BI8|rcsb pdb:6FFA|rcsb pdb:6XA9|reactome:R-HSA-1169408|reactome:R-HSA-168276|reactome:R-HSA-168928|reactome:R-HSA-5656169|reactome:R-HSA-909733|reactome:R-HSA-936440|dip:DIP-29814N	intact:EBI-15810860(chain-parent)	-	-	chain-seq-start:819|chain-seq-end:2740	figure legend:Fig. 5c, Table 1|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/09/02	2020/09/03	rogid:k01VuKv72XNTX3hhlIT4Lr0Xl849606	rogid:NKZ5d0D2HjefhmJQwgHz+M1lSt8694009	rigid:/TYItRhFkSsY/tD53UtmHDS5S20	false	fluorophore:c-c	sufficient binding region:723-1037|mutation decreasing interaction rate:888-888|mutation with no effect:930-930|mutation increasing interaction rate:954-954	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P0C6U8-PRO_0000338257	uniprotkb:P05161	intact:EBI-25635190	intact:EBI-746466|uniprotkb:Q7Z2G2|uniprotkb:Q96GF0|intact:EBI-1056284|uniprotkb:Q5SVA4|ensembl:ENSP00000496832	psi-mi:p0c6u8-pro_0000338257(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:isg15_human(display_long)|uniprotkb:ISG15(gene name)|psi-mi:ISG15(display_short)|uniprotkb:G1P2(gene name synonym)|uniprotkb:UCRP(gene name synonym)|uniprotkb:Interferon-induced 15 kDa protein(gene name synonym)|uniprotkb:Interferon-induced 17 kDa protein(gene name synonym)|uniprotkb:Ubiquitin cross-reactive protein(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Daczkowski et al. (2017)	pubmed:28438633|imex:IM-28308	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25823247|wwpdb:5TL6|imex:IM-28308-39	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-15810860(chain-parent)	refseq:NP_005092.1|ensembl:ENSG00000187608(gene)|ensembl:ENST00000649529(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009615"(response to virus)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031386"(protein tag)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032020"(ISG15-protein conjugation)|go:"GO:0032461"(positive regulation of protein oligomerization)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034340"(response to type I interferon)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0070585"(protein localization to mitochondrion)|interpro:IPR000626(Ubiquitin)|interpro:IPR019956|interpro:IPR029071|mint:P05161|rcsb pdb:1Z2M|rcsb pdb:2HJ8|rcsb pdb:3PHX|rcsb pdb:3PSE|rcsb pdb:3R66|rcsb pdb:3RT3|rcsb pdb:3SDL|rcsb pdb:5TL6|rcsb pdb:5W8T|rcsb pdb:5W8U|rcsb pdb:6BI8|rcsb pdb:6FFA|rcsb pdb:6XA9|reactome:R-HSA-1169408|reactome:R-HSA-168276|reactome:R-HSA-168928|reactome:R-HSA-5656169|reactome:R-HSA-909733|reactome:R-HSA-936440|dip:DIP-29814N	-	chain-seq-start:819|chain-seq-end:2740	-	figure legend:Table 3|3d-resolution:2.62Å|3d-r-factors:"Rwork: 0.191  Rfree: 0.25"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/09/02	2020/09/03	rogid:NKZ5d0D2HjefhmJQwgHz+M1lSt8694009	rogid:k01VuKv72XNTX3hhlIT4Lr0Xl849606	rigid:/TYItRhFkSsY/tD53UtmHDS5S20	false	sufficient binding region:723-1037|his tag:c-c	sufficient binding region:80-157	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q64339	uniprotkb:P0C6U8-PRO_0000338257	intact:EBI-8345781|uniprotkb:Q8K0H3|intact:MINT-4139466|ensembl:ENSMUSP00000082548	intact:EBI-25635190	psi-mi:isg15_mouse(display_long)|uniprotkb:Isg15(gene name)|psi-mi:Isg15(display_short)|uniprotkb:G1p2(gene name synonym)|uniprotkb:Ucrp(gene name synonym)|uniprotkb:Interferon-induced 15 kDa protein(gene name synonym)|uniprotkb:Interferon-induced 17 kDa protein(gene name synonym)|uniprotkb:Ubiquitin cross-reactive protein(gene name synonym)	psi-mi:p0c6u8-pro_0000338257(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	Daczkowski et al. (2017)	pubmed:28438633|imex:IM-28308	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25823478|wwpdb:5TL7|imex:IM-28308-51	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056598.2|ensembl:ENSMUSG00000035692(gene)|ensembl:ENSMUST00000085425(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031386"(protein tag)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032020"(ISG15-protein conjugation)|go:"GO:0032461"(positive regulation of protein oligomerization)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034340"(response to type I interferon)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0070585"(protein localization to mitochondrion)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|mint:Q64339|rcsb pdb:5CHF|rcsb pdb:5CHV|rcsb pdb:5CHW|rcsb pdb:5JZE|rcsb pdb:5TL7|rcsb pdb:5TLA|rcsb pdb:6J62|rcsb pdb:6YVA|reactome:R-MMU-1169408|reactome:R-MMU-5656169	intact:EBI-15810860(chain-parent)	-	function:"In response to IFN-tau secreted by the conceptus, may ligate to and regulate proteins involved in the release of prostaglandin F2-alpha (PGF), and thus prevent lysis of the corpus luteum and maintain the pregnancy"|comment:mint|function:Ubiquitin-like protein that is conjugated to intracellular target proteins after IFN-alpha or IFN-beta stimulation. Its enzymatic pathway is partially distinct from that of ubiquitin, differing in substrate specificity and interaction with ligating enzymes. ISG15 conjugation pathway uses a dedicated E1 enzyme, but seems to converge with the Ub conjugation pathway at the level of a specific E2 enzyme. Targets include STAT1, SERPINA3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, EIF2AK2/PKR, MX1/MxA, and RIG-1. Deconjugated by USP18/UBP43. Shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. May serve as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments. May also be involved in autocrine, paracrine and endocrine mechanisms, as in cell-to-cell signaling, possibly partly by inducing IFN-gamma secretion by monocytes and macrophages. Seems to display antiviral activity during viral infections	chain-seq-start:819|chain-seq-end:2740	figure legend:Table 3|3d-resolution:2.44Å|3d-r-factors:"Rwork: 0.192  Rfree: 0.267"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/09/02	2020/09/03	rogid:rLwDq3/OLBVXU0U9MVyiTeULqog10090	rogid:NKZ5d0D2HjefhmJQwgHz+M1lSt8694009	rigid:Qs+CKVQJRvmpeRhw7gjB45bl3Tg	false	sufficient binding region:78-155	sufficient binding region:723-1037|his tag:c-c	1	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)